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To Keep Climate Science Alive, U.S. Researchers Are Speaking in Code
Words considered "woke" are vanishing from research proposals. Grist tracked the changes.
Former Bears QB made UFL history in Renegades debut
Former Bears quarterback Austin Reed made UFL history in his first game with the Renegades.
Browns' frontrunner at QB revealed by NFL insider Mike Garafolo
Who will start at quarterback for the Browns in 2026? One NFL insider thinks he knows who the current frontrunner is...
Cleveland Browns NFL Draft Profile: QB Garrett Nussmeier, LSU
What to make of Nussmeier’s NFL potential? And are the Browns in a position to risk finding out?
NBA playoff picture March 29: All of the scenarios and stakes for postseason contenders down the stretch run
Meet Leigh Cuen, The Tennessean's new music editor
Veteran journalist Leigh Cuen joins The Tennesseean as music editor.
How Jaxson Dart's presence has changed everything for NY Giants
A year ago, the Giants were in the middle of a desperate search for their franchise QB. Jaxson Dart has completely altered the narrative.
UEFA confirm Champions League semi-final details
UEFA have confirmed the details for the Champions League semi-finals, with Arsenal potentially in line for a trip to Spain if they can make it past Sporting CP.Photo by Marco Luzzani/Getty ImagesUEFA ...
And then Jamal Murray had a 31-point, 14-assist …
And then Jamal Murray had a 31-point, 14-assist …
New York Jets Flight Connections 03/28/26
Happy Saturday, Jets fans! Below are your links to kick off this weekend as we keep cruising toward the 2026 NFL Draft. NY Jets – Where Have the Jets Improved their Roster Most this Offseason? Jack Bell – Jets QB Geno Smith: Aaron Glenn is a ‘Special Coach’ Jack Bell – At No. 2 Overall […]
MAGA’s eruption has so far kept Trump from endorsing in key Senate race
President Donald Trump seemed set to endorse Sen. John Cornyn in the Texas Republican primary runoff. But strong opposition from MAGA activists forestalled that.
Royals fall to Atlanta, 6-0
This was probably not the best ball the Royals will play this year.
How important is QB1 in the NFL Draft?
Is Ty Simpson QB1? Why situation may matter more than rankings in the NFL Draft.
NBA news, live updates: League proposes new anti-tanking ideas; Friday's playoff scenarios
87-year-old planetarium projector still dazzles visitors at Springfield Science Museum
The device is not only a technological marvel, but could easily be an exhibit in the very museum where it remains in operation.
UConn football hopefuls work out on Husky Pro Day
After recording back-to-back nine-win seasons, UConn has a number of former players vying for a chance at the NFL or other pro leagues. On Tuesday, the players had the opportunity to showcase their skills in front of 27 NFL scouts at UConn’s 2026 Pro Day. The group included the following numbers at each position: QB: […]
Did Scientists Just Detect an Exploding Black Hole?
An underwater observatory recently detected a startlingly energetic cosmic neutrino. One possible cause involves a phenomenon that so far exists only in theory.
Jordan Love gifts cleats to local youth sports teams
Packers QB Jordan Love met with four local youth sports teams to gift them new cleats ahead of their upcoming seasons as a part of his foundation's '10ve for Cleats' campaign.
WhatsApp rolls out updates including multiple accounts for iOS
WhatsApp shared multiple quality of life updates coming to its messaging platform starting today.
AdeptiCon Preview 2026 – A new Lumineth Realm-lords warband breezes into Warhammer Underworlds
Awesome aelves and their adorable vulpine spirit revealed.
James Talarico Responds With ‘Love’ To Hegseth Pastor’s Criticism
James Talarico, the Democratic nominee for Senate in Texas, said, “You may pray for my death, Pastor, but I still love you.” The pastor said he was calling for Mr. Talarico’s religious conversion.
NSF initiative aims to make every American worker, business and community AI-ready
The U.S. National Science Foundation announced a new funding opportunity as part of an effort to enable all Americans to understand, apply and create with artificial intelligence. The NSF TechAccess…
EQB welcomes Daniel Rethazy as EVP, Personal Banking, adding top banking talent to reignite core business growth and execute on transformation
EQB Inc. (TSX: EQB) today announces Daniel Rethazy's appointment as Executive Vice President, Personal Banking. Mr. Rethazy brings deep experience in Canadian Banking to EQB that will accelerate momentum and unlock a new era of growth for the company's Personal Banking franchise, delivering a more competitive and rewarding banking experience, and a stronger and more resilient banking industry for all Canadians.
DJ Lagway leaves Florida drama behind him, rewriting his story at Baylor
DJ Lagway was No. 1 QB in his recruiting class. But self-induced isolation and a run of injuries derailed Florida career. Baylor is a fresh start.
Fox Sports Host weighs in on the Chiefs acquiring QB Justin Fields
During a recent media appearance, Fox Sports Host Nick Wright weighed in on the Kansas City Chiefs acquiring quarterback Justin Fields | @EdEastonJr
Falcons introduce quarterback Tua Tagovailoa
Watch: Falcons QB Tua Tagovailoa introduced in virtual press conference
Joe Flacco returning to Bengals: 41-year-old QB set for 19th NFL season in 2026
Flacco is coming off his first Pro Bowl selection.
Mr. Tire employee arrested for twice setting fires at the business: Solon Police Blotter
Also in this week's blotter, the driver of a Jeep SUV would not stop for Solon police, who were attempting to cite him for an expired license plate.
Prisco's 2026 NFL mock draft 1.0: Four of top five picks on defensive side, Browns select QB
Teams at top of the draft opt for pass rush over offense.
Live Science Today: Earth hits record energy imbalance, Hawaii floods and NASA prepares for Artemis II launch
Monday, March 23, 2026: Your daily roundup of the biggest science stories making headlines.
In California, a Republican Sheriff Seizes Ballots, Prompting Concerns
Riverside County Sheriff Chad Bianco, a candidate for governor, recently took possession of more than 650,000 ballots as part of a fraud probe. Election officials say his investigation is baseless.
Incredible offer signals Liverpool are all-in on Rio Ngumoha
An incredible offer of a player signals a real intent from Liverpool to go all-in on teenager Rio Ngumoha.Are Liverpool about to go all-in on Rio Ngumoha? They’ve been reluctant to do so this season...
UFL team signs former Alabama high school, Crimson Tide QB
The Thompson High School alumnus had been scheduled to play in the Indoor Football League on Sunday.
Your Thymus and Your Healthspan
Our thymus gland plays a central role in the development or our immune system, specifically for supporting T cell development (how these cells got their name, maturation and differentiation in the thymus) and discriminating between self and foreign, non-self antigen proteins with production of dendritic cells. As we age, our thymus gland shrinks—the process known as involution—with progressive change from spongy to fatty tissue, with loss of functionality. But this process, with respect to timeline and extent, markedly varies from one person to the next. And to make things even more complicated, our thymus gland anatomy and precise location in the chest also is highly variable. So the famous Frank Netter diagrams from the 1960s (such as at left below) don’t capture the remarkable heterogeneity that a random set of 12 chest CT scans (below at right). What I consider as 2 landmark papers in Nature this week (here and here) used AI to quantify health of the thymus in 2 large cohorts, and then correlate the metric to a broad array of health outcomes. In this edition of Ground Truths, I’m going to cover three questions: (1) How was thymus health determined by AI?; (2) How is thymus health linked to key clinical outcomes? and (3) Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? Subscribe 1. How was thymus health determined by AI? This was accomplished by extensive work developing and validating an AI pipeline for 2 stages, the first for localization and segmentation of the thymus bed, and the second to quantify a digital marker, termed the thymic health score. There’s a lot to this algorithmic development, so I won’t go into all the details, but just provide a rudimentary outline of what was done. The 1st stage used supervised learning with 2 radiologists reviewing 2,461 chest CT scans. That work trained a 3D U-Net model to automatically identify the thymic bed’s 3D cropped region using center of mass coordinates, which reached 99.8% accuracy. The 2nd stage used a foundation model that was pre-trained with SwAV (which stands for Swapping Assignment between multiple Views), a self-supervised model, that generated a high-dimensional thymus representation of 4,096 features. That compares to the radiology reductionist and subjective scoring of 0 to 3 where 0 means the thymus is fully degenerated and fatty, and 3 is considered dense, intact glandular soft tissue. Notably, the self-supervised learning (SSL) performance was superior to supervised (AUC ~0.75 vs 0.55, respectively) reflecting the shallowness of the 0-3 classifier vs SSL’s holistic, self-taught AI. The thymic health score ranged from 0 to 100, with the highest number indexed to fully preserved thymic health. The algorithmic work extended to explainability with both Shapely value distribution, meaning the model was holistic not relying on any “magic” pixel, and occlusion sensitivity, demonstrating the model’s performance was not affected by ribs, sternum, lung tissue, but rather focused on the thymic bed directly. Below are a few saliency maps from the occlusion sensitivity that indicate the thymic bed focus, not affected by neighboring structures, using the jet color scale. Now the AI was ready for processing ~25,000 CT scans, each over 30 MB files, from the 2 large participant cohorts to provide a thymic health score, it did so in less than 14 hours, which is less than 2 seconds per scan! Share 2. How is thymus health linked to key clinical outcomes? The two cohorts were the National Lung Screening Trial, NLST (N=25,031) and the Framingham Heart Study, FHS (N=2,581) each with baseline demographics and long term follow up of >12 years for health outcomes. From the NSLT, you can see below that increased age and body-mass index were correlated to reduced thymic health. And, overall, men had reduced thymic health scores compared with women. There are a lot of graphs in the paper for outcomes, for both the NLST and FHS cohorts. To simplify the major outcomes, below is a composite Figure with striking reduction of all-cause mortality and for the different causes of death. The results were consistent between the 2 cohorts. For example, the cardiovascular mortality hazard ratio average was 0.57 in NLST and 0.38 in FHS (weighted to be 0.53 for the aggregate). The reduction of mortality also extended to digestive diseases and pulmonary disease (data not shown below). Lung cancer incidence was reduced by 36% for high vs low thymic health (Figure below, with a panel -incidence and b panel-mortality, adjusted for age, sex, BMI, smoking status). Notably, there was a smoker’s paradox: lower incidence and improved survival for lung cancer in smokers who had a high thymus health score. Smoking was associated with lower thymic scores whereas alcohol was not. Higher thymic health was linked to higher HDL cholesterol, lower triglycerides, lower fasting blood glucose, and lower systolic and diastolic blood pressure. Inflammation biomarkers, such as C-reactive protein and interleukin-6, were elevated in the people with lower thymic health scores. In their second paper, the same team looked at the relationship between thymic score and outcomes for 3,476 patients receiving cancer immunotherapy. The non-small cell lung cancer progression-free survival was reduced in patients with low thymic health score. A parallel relationship for survival was seen for other types of cancer including melanoma, breast, and kidney with a 44% lower risk among high thymic scores (Figure). A similar pattern was seen with different immune checkpoint inhibitors. The thymus health score outperformed programmed death ligand-1 (PD-L1)and tumor mutation burden (TMB) assay of the tumor and was an independent prognostic marker of progression-free survival. In this dataset, a direct connect with thymus score and adaptive immune function was noted with a correlation before cancer treatment for both T-cell diversity and thymus T-cell production (a metric known as T cell receptor excision circles). Thymus Removal Study There is a highly relevant citation about thymus function before moving onto ways to rejuvenate it. In 2023, a very important study of thymus removal during cardiothoracic surgery was published, with 1146 patients undergoing thymus removal vs 1146 matched controls (mean age 55 years). The adverse outcomes for thymus removal were striking, with a 2.9 higher risk of all-cause mortality and doubling of cancer incidence, 1.5 fold increase in cancer mortality, and 1.5-fold increase in autoimmune diseases. The immune function showed marked compromise after thymus removal, as reflected by CD4+ and CD8+ T cells (Figure below) Share Ground Truths 3. Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? In recent months we’ve learned a lot about the process of thymus involution and the pathways by which this may be modulated. Thymus involution is primarily due to loss to thymus epithelial cells (TECs) and there are 2 subtypes with different functions: the cortical, responsible for positive selection of T cells, and the medullary, for negative selection. When adipose tissue infiltrates the thymus, thymic adipocytes are pro-inflammatory, knocking out T-cell output. Likewise, systemic inflammation, or “inflammaging,” from smoking, obesity, and chronic stress promote thymic adipocytes. Now, from preclinical studies, we know about key pathways that account for these processes. Historically, back in 2014, FOXN1 was recognized as a single master transcription factor essential for TEC function, with studies in mice with forced FOXN1 upregulation leading to thymus regeneration. That laid the foundation for potential regrowth of quiescent thymus cells. It took awhile to find pathways to accomplish this goal and to even refute its role as the master regulator. The Liver-Thymus Axis Feng Zhang and his team recently showed that injection of an mRNA vaccine to the liver encoding DLL1, IL-7 and FLT3-L in combination, factors known to support thymopoiesis (Figure), successfully enhanced immune function in aged mice. However, the effect was transient. The FGF21 Story Two reports in 2025 addressed the thymus gland’s production of FGF21, a growth factor (fibroblast growth factor 21) and its control of thymus involution. This growth factor is also produced by the liver, but it doesn’t have impact on the thymus in aged rodent models. In contrast, The liver’s hepatocyte growth factor (HGF) has been shown to reverse senescent TEC structural changes. Growth hormone stimulates production of insulin growth factor-1 (IGF-1) in the liver and the thymus. Two small studies in human participants (TRIIM, for Thymus Regeneration, Immunorestoration, and Insulin Mitigation) of 6 and 50 people, respectively, treated with combined human growth hormone, metformin and DHEA, suggested the potential of slowing epigenetic aging and improving thymus mass and function. But the combination of drugs, small sample, and lack of controls make conclusions murky. Increased thymus FGF21 led to increased CD8 T cells in old mice and extended healthspan and improved physical performance. Building on the previous FOXN1 data, ablation of β-klotho, the obligatory co-receptor for FOXN1, accelerated thymic aging. The benefit to FGF21 was confirmed in a companion paper using an FGF21 knock-in mouse model showing thymus enlargement and increased TECs throughout the lifespan. (schematic Figure below). The accompanying editorial for these 2 papers speculated: “The proposed link between age-associated thymus involution and organismal aging is intriguing, and suggests we might seek to achieve systemic rejuvenation by counteracting thymic involution.” Other Factors Lessons from the Axolotl (Mexican Salamander) In an elegant set of experiments of the axolotl (Figure), known for its complete thymus regeneration after total surgical removal, mediators were identified. Surprisingly FOXN1 was dispensable. But midkine, a growth factor, appeared to be the driver, the initiator of thymus cell growth, survival, and repair. Other components that contributed were Postn+ (periostin-expressing mesenchymal niches) and Ccl19, a chemokine protein from the bloodstream. RANK and RANKL RANK (receptor activator of nuclear factor κB its ligand (RANKL) have been considered key regulators of medullary TECs. In a study of both aged mice and human thymus cell cultures, their key role was confirmed, with multiple benefits of resorting TEC function, recruitment of progenitor cells, and T cell development. Subscribe Summing Up This body of work strongly supports the health of the thymus gland as a critical regulator of human healthspan, not just a correlate or link. The new landmark studies are reinforced by the regenerative biology experimental models that have shown, via an array of mediators, that healthspan of aged mice is at least in part dependent on thymus gland function and its critical role for maintaining adaptive immunity. It sure seems that we’d be better off having an immune reservoir of naive T cells instead of a profile in older adults of exhausted, low quality, memory T cells, with a senescent phenotype. It is striking that we ignored the importance of the thymus gland for many decades. A wake-up call was the results of the thymectomy matched control study reviewed here, with the opposite of high thymic health score improved health outcomes. The convergence of AI and healthspan here is notable. The exceptional and laborious work for developing and validating (no less explaining) the AI to quantify thymus health set the foundation for probing the connect the major health outcomes in two cohorts with extensive follow-up. We’ve never had a way to meaningfully quantify the thymus gland before, so this represents important leverage of supervised, self-supervised, and transformer models. The study wouldn’t have been possible without AI. And it begs the question as to whether there are ways we can maintain our thymus at a high health score. But it’s not so simple to rejuvenate our thymus. There are multiple risks including the induction of autoimmunity, increasing the risk of cancer, and inducing a pro-inflammatory state. For example, factors that increase TEC proliferation could compromise the medulllary negative selection process and leak out auto-reactive (self-attacking) T cells. Thymic cells could be induced to proliferate, but we know, for example, that growth hormone and IGF-1 are associated with an increase risk of cancer. If thymus rejuvenation doesn’t clear out the accumulated senescent cells in older adults, then inflammation within the gland could block the production of TECs. Keeping these risks in mind, we now have identified many ways to keep our thymus healthy as we age that undoubtedly will be tested in clinical trials going forward. Ultimately, the benefit-to-risk tradeoffs will be defined. In the meantime, we have desperately needed an immunome. As I’ve stressed in multiple prior Ground Truths, we have no test in the clinic to assess a patient’s immune status! It was very encouraging for me to get an email from Hugo Aerts, the senior author of the landmark papers in the days after they were published: “I also wanted to say that your Substack on “Why We Need an Immunome” was inspiring for this work. We found it a very compelling perspective and greatly enjoyed reading it.” Just having an assessment of a person’s immune status via a chest CT scan, with millions of these performed per year, might help in guiding the right immunotherapy for cancer (e.g. more intensive, combinations for those with low thymic health scores) and help define people who are increased risk for age-related diseases of cancer, cardiovascular, and neurodegenerative. The main theme of Super Agers is that we now have many layers of data (genetics, proteins, biomarkers, organ clocks that can be integrated via multimodal AI) for us to define a person’s specific risk decades before one of these age-related diseases leads to symptoms, enabling prevention. From the new studies this week, we can add thymus health score as yet another way to understand a person’s risk, a window into their adaptive immune system and healthspan. And perhaps someday we will be able to safely rejuvenate the thymus, or maintain its health through one’s life, and use the thymus health score to monitor. NB: I wrote this post (No A.I.) A Quick Poll Loading... ********************************************************************* Thanks to Ground Truths subscribers (now > 200,000) from every US state and 212 countries. Your subscription to these free essays and podcasts makes my work in putting them together worthwhile. Please join! If you found this interesting PLEASE share it! Share Ground Truths Paid subscriptions are voluntary and all proceeds from them go to support Scripps Research. They do allow for posting comments and questions, which I do my best to respond to. Please don’t hesitate to post comments and give me feedback. Let me know topics that you would like to see covered. Leave a comment Many thanks to those who have contributed—they have greatly helped fund our summer internship programs for the past two years. It enabled us to accept and support 47 summer interns in 2025! We aim to accept even more of the several thousand who will apply for summer 2026.
NFL Network: What's next for Bills QB Josh Allen? (video)
NFL Network roundtable looks ahead to Josh Allen and the Bills in 2026.
The Supreme Court Could Make it Harder to Vote by Mail in the Midterms
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Live Science spoke with Herman Pontzer, an evolutionary anthropologist and author of the book "Adaptable," about the science of human diversity.
In Opening Day preview, Mariners thrash Guardians, 20-8
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More Subnautica 2 legal trouble brewing amid claims Krafton "intentionally leaked" May release without consulting reinstated CEO
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Belkin Charging Case Pro for Switch 2 review: A more elegant solution
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InSo brings fine dining, nightlife entertainment to Las Colinas
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Steelers await Aaron Rodgers decision as NFL draft nears
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No. 16 Siena nearly upsets No. 1 Duke in NCAA tournament while making only 1 sub ... for 2 seconds
Latest Vikings QB move a red flag for J.J. McCarthy
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Mullin addresses temper, ‘secret’ trip at DHS hearing
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March Madness bracket scores: Miami (Ohio) wins first NCAA tournament game since 1999, makes statement against SMU in First Four
Andy Dalton trade: Eagles acquire veteran QB, send seventh-round pick to Panthers
Dalton will join the sixth team of his NFL career
Eagles add veteran backup QB in trade with Panthers
The Eagles have pulled off a trade with the Panthers for veteran backup quarterback Andy Dalton.
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Business listings: See 42 new businesses in Central NY (Mar. 17, 2026)
See a list of filings in Onondaga, Madison and Cayuga counties.
Chiefs Reportedly Make Trade With Jets For Former Steelers QB
Justin Fields is on the move again. On Monday, NFL insider Adam Schefter reported that the New York Jets are reportedly trading Fields to the Kansas City Chiefs in exchange for a 2027 sixth-round draft pick. The deal is still pending a physical. Other teams were reportedly interested in Fields, but his preference was to […]
Judge Strikes Down Kennedy’s Vaccine Policies
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Oregon QB Dante Moore reveals struggles with mental health
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Mob Entertainment Expands the World of Poppy Playtime with New Official Online Merchandise Store
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Former Steelers quarterback traded to Chiefs
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Titans agree to restructure Calvin Ridley's contract for 2026
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Brewers beat Rockies 8-4 behind Misiorowski and Sproat
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These Marshfield businesses & churches closed March 15-16 due to snow
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Doja Cat reveals BPD diagnosis while defending Chappell Roan
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Match Preview presented by DigAlert: LA Galaxy vs Sporting Kansas City
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Meta to Shut Down Instagram End-to-End Encrypted Chat Support Starting May 2026
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Vikings Land Kyler Murray: Real QB Competition or McCarthy Funeral?
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Kenneth Gainwell: 'All About Business'
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Multimodal embeddings at scale: AI data lake for media and entertainment workloads
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Primary Care Must Be Protected As Hawaiʻi’s Health System Evolves
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Torrent Come From Behind To Beat First Place Boston
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Houston Dominates Glass, Still Loses Big to Denver
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Kyler Murray weighing Vikings, backup spots
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Beyond The Burn Zone: Maui Wildfires Cause Widespread Mental Health Issues
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Wisconsin football extends offer to recently decommitted Louisville QB
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Science Shorts: Rice for weight control, functional dairy tech and more
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3D human liver reconstruction reveals changes in cirrhosis
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Bay City Fireworks Festival responds to concerns about band performance
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Vikings Add CB James Pierre from Steelers
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YouTube expands deepfake detection tool to politicians and journalists
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Business listings: See 46 new businesses in Central NY (Mar. 10, 2026)
See a list of filings in Onondaga, Madison and Cayuga counties.
2026 NFL Draft Scouting Report: Ty Simpson, QB, Alabama
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Trump’s wearing of baseball cap during dignified transfer draws criticism
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NBA cancels Atlanta Hawks' plans to celebrate famed Magic City adult entertainment club
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F.D.A. Opens Door to More Flavored E-Cigarettes
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