SCROLL NEWS / DISCOVERY
Search headlines
Find the stories shaping the conversation.
Results for " Pace " 3,886 found 🔀 AI-powered Shuffle
Business English for Workplace Communication (2026): EF English Live Recognized for Practical, Speaking-Focused Learning by Better Business Advice
Better Business Advice has named EF English Live a recommended online learning option for business English and workplace communication in 2026. It looks at how the platform uses live classes, realistic workplace scenarios, and self-paced practice to help adults communicate more confidently in professional settings.
How does one of downtown New Orleans' biggest office space holders see the market?
Lahaksy is at the helm of nearly 1.5 million square feet of downtown office space.
Disney Believe to debut new entertainment and dining experiences in December 2027
Disney Cruise Line’s Disney Believe will enter service on 18 December 2027, with the new Wish-class ship set to introduce new entertainment, dining and accommodation across its public spaces and...
holding space in music therapy for patients with dementia
They call it music therapy, which is too imprecise a term to describe what really happens sometimes, when music touches a person sliding into eternity through a gradually darkening tunnel
Arkansas Children’s Northwest completes major expansion
Arkansas Children’s Northwest in Springdale completed an $82.7 million expansion, adding 15 inpatient beds and 50,000 square feet of new space, and renovating 23,000 square feet. On Wednesday (Oct. 7),...
Detroit Free Press
District 142 is expanding in downtown Wyandotte with District Sound Lounge, a music-themed space with food, drinks, memorabilia and entertainment. See link below ⬇️ 📸 Provided by District 142
Margaret Hamilton, whose software helped land Apollo astronauts on the moon, has died
The groundbreaking researcher who helped create the field of software engineering and whose code helped land NASA win the 20th century space race, has died at 90.
SpaceX is a real company, with real numbers and real business, says Jim Cramer
'Mad Money' host Jim Cramer takes a look at Goldman Sachs' recent price target change on SpaceX and what is behind it.
Margaret Hamilton, Whose Software Guided the Apollo Missions, Has Died
Margaret Hamilton, the first female programmer hired to work on the space project at M.I.T., was 90.
Space activities and a brewing science night coming to Spark Science Center
The Spark Science Center is celebrating World Space Week with two hands-on programs, and a week later it will launch a new adult-only series with a look at the science of brewing.
General Dynamics names next CEO, as Novakovic becomes exec chairman
Phebe Novakovic, General Dynamics' longtime CEO, will transition to executive chairman on Jan. 1, 2027, as President Danny Deep becomes the Fortune 500 aerospace and defense contractor's next leader, the Reston-based company announced Wednesday.
NASA’s PRIMA Spacecraft (Artist’s Concept)
This artist’s concept depicts the proposed design for NASA’s PRobe far-Infrared Mission for Astrophysics (PRIMA), which was selected by the agency in
Trump Expected to Award Science Medal to SpaceX's Elon Musk, Fox News Reports
Elon Musk is set to receive the National Medal of Science from President Donald Trump. Discover the news here.
Lansing’s crown boxing athletes train hard to learn the sweet science
The popular facility hosts a wide range of boxers, from young beginners to adults looking to improve. All find a space to learn and grow.
Trump expected to award science medal to SpaceX's Elon Musk, Fox News reports
US President Donald Trump is expected to award the National Medal of Science to SpaceX CEO Elon Musk, Fox News reported.
Trump expected to award science medal to SpaceX’s Elon Musk, Fox News reports
Trump expected to award science medal to SpaceX’s Elon Musk, Fox News reports
Trump expected to award science medal to SpaceX’s Elon Musk, Fox News reports
WASHINGTON, Oct 7 (Reuters) - US President Donald Trump is expected to award the National Medal of Science to SpaceX CEO Elon Musk, Fox News reported. The National Medal of Science is the nation's highest honor for scientists and engineers, accor...
Trump expected to award science medal to SpaceX’s Elon Musk, Fox News reports
WASHINGTON, Oct 7 (Reuters) - US President Donald Trump is expected to award the National Medal of Science to SpaceX CEO Elon Musk, Fox News reported. The National Medal of Science is the nation's highest honor for scientists and engineers, accor...
Trump Expected to Award Science Medal to SpaceX's Elon Musk, Fox News Reports
By Courtney Rozen WASHINGTON, Oct 7 (Reuters) - US President Donald Trump is expected to award the National Medal of Science to SpaceX CEO Elon Musk, Fox News reported. (Reporting by Courtney Rozen; Editing by Nia Williams) Copyright 2026 Thomson Reuters.
Scientists uncover how the world's smallest flowering plant became so tiny
A new study has revealed how some plants pack the same structures as larger species into a tiny space, making them promising candidates for future crops.
Amendment 78: New Opportunity: B.7 Heliophysics Low-Cost Access to Space
The Heliophysics Low-Cost Access to Space (H-LCAS) program (B.7 of ROSES) solicits proposals for the development and application of innovative instruments,
Gold Coast retail space once home to Marcus Lemonis’s boutique heads to auction
Marcus, an upscale women’s clothing store owned by celebrity entrepreneur Marcus Lemonis and his wife shuttered its location there in August 2025.
Earth Science Tech (ETST) Building on Synergies Between Healthcare Related Subsidiaries to Generate Dependable and Growing Revenue
Austin, Texas, October 7th, 2026, FinanceWireEarth Science Tech (OTCQB: ETST), a strategic holding company that brings together innovative businesses across the healthcare, pharmacy, technology and telemedicine, real estate, and consumer products spaces, operates Avenvi LLC, a real estate and asset…
Trump expected to award science medal to SpaceX's Elon Musk, Fox News reports
By Courtney Rozen WASHINGTON, Oct 7 (Reuters) - US President Donald Trump is expected to award the National Medal of Science to SpaceX CEO Elon Musk, Fox News reported.
LaMelo Ball Might Have Just Unlocked a Secret Timberwolves Weapon
LaMelo Ball’s most obvious impact on the Minnesota Timberwolves will come through his passing, pace and ability to make life […]
Housing, retail and entertainment space proposed near Highmark Stadium
Architectural design group Progressive Companies presented concepts Tuesday for a new area just beyond the old Highmark Stadium area.
Webb finds a surprising atmosphere on a scorching lava world
The James Webb Space Telescope has found strong evidence that the rocky lava world HD 3167 b has an atmosphere, despite circling its star every 24 hours under extreme heat. The surprising discovery could help scientists understand how rocky planets retain atmospheres and what the young, molten Earth may once have looked like.
Here Are Wednesday’s Top Wall Street Analyst Research Calls: Abbott Laboratories, AppFolio, Delek US Holdings, Flutter Entertainment, Honeywell Aerospace, Intuitive Surgical, Marvell, NetApp, and More
Pre-Market Stock Futures: Futures are trading lower as today’s oil and interest rates are higher. Baseball legend Babe Ruth was often credited with the saying, “Records are made to be broken,” and Tuesday was one of those days for the stock market. For the second straight day, all major indices ended higher, with only the […]
Purdue, Elanco break ground on One Health Research Institute
Purpose-built research, incubator and laboratory space will leverage Purdue’s R1 capabilities and Elanco’s animal health leadership.
Earth's magnetic field: An enigma that could affect how long we live
Generated by a vast dynamo-like churn of molten iron in the Earth’s core, the magnetic field that surrounds the planet protects its surface and everything on it from space radiation as well as helping...
Read the memo Skydance product chief sent after Paramount-WBD merger
The product chief at Skydance said in a memo to staff after the Paramount and WBD merger that they will "move at a pace that matches our ambition.'
Sheridan vs. Aurora Science & Tech: Colorado High School Boys Soccer, Oct. 7, 2026
Sheridan at Aurora Science & Tech, Colorado high school boys soccer, Oct. 7, 2026, 4:00 PM. 2A/3A league game: records, rankings, rosters and head-to-head.
Sheridan vs. Aurora Science & Tech: Colorado High School Girls Volleyball, Oct. 7, 2026
Sheridan at Aurora Science & Tech, Colorado high school girls volleyball, Oct. 7, 2026, 4:30 PM. 2A/3A league game: records, rankings, rosters and head-to-head.
EB Games Is Opening North America's First-Ever Nintendo "Store-Within-A-Store" Experience
A "new permanent Nintendo space" arrives later this month
Pixar exhibit brings movie magic to Frost Science
Buzz Lightyear may have doubts about humans and space travel, but when it comes to bringing Pixar characters to life, filmmakers take technology to infinity and beyond.
NYC Health + Hospitals/Kings County Unveils Large-Scale Mural Celebrating Healing, Resilience, and Hope
Brooklyn, NY – NYC Health + Hospitals/Kings County is bringing art into an everyday hospital space through Patient’s Pathway, a large-scale mural by
Deposition Sciences, Inc. Expands Sunshade® Tape Offering with New 12" × 30" Format
Deposition Sciences, Inc. Expands Sunshade® Tape Offering with New 12" × 30" Format
Pokemon Cards Sent to Space for the First Time!
Pokemon cards have reached outer space! As part of its collaboration with the European Space Agency for World Space Week, TPCi today revealed that
SpaceX Reveals How Close Other Satellites Get to Its Starlink Constellation
A SpaceX executive says a lack of coordination among rival satellite operators could imperil Starlink, citing the risk of collisions.
Pikachu spent 67 days in space
To celebrate World Space Week, the ESA and Pokémon are joining forces.
Tritec holds groundbreaking for newest phase at Station Yards
Tritec Real Estate breaks ground on Phase 2C of Station Yards in Ronkonkoma, adding 285 apartments and medical office space.
Battlefield 6 Resurrects the Corpse of Dead Space With The Marker Tease
The corpse of Dead Space is being reinimated for Battlefield 6, with the latest trailer for Season 5 seemingly teasing a crossover.
NASA’s SunRISE Mission Targets No Earlier Than Mid-2027 Launch
NASA’s SunRISE (Sun Radio Interferometer Space Experiment) mission will launch no earlier than mid-2027. The heliophysics mission will hitch a ride on a
EB Games announces first ever Nintendo store-within-a-store in North America
Today, EB Games announced the first-ever Nintendo store-within-a-store experience in North America. The space will be located in the heart of Toronto. EB Games will open the Nintendo space at its flagship location at 267 Yonge Street. This is a permanent, 1,500-square-foot space that “will bring Nintendo games, characters and worlds together in a dedicated retail environment.” The new Nintendo...
Pacers Given Interesting Win Total Despite Tyrese Haliburton Return
The Indiana Pacers have been given an interesting win total prediction entering the new NBA season.
Pacers' Tyrese Haliburton Already 'Enjoying Playing' With Ivica Zubac
Indiana Pacers guard Tyrese Haliburton is already having fun playing with center Ivica Zubac.
US Congresswoman Joins Fight to Keep Cannabis Legal in Massachusetts
Rep. Ayanna Pressley is urging Massachusetts voters to reject a ballot measure that aims to repeal the state’s adult-use cannabis laws.
A Space Disaster Is Coming Unless We Take Kessler Syndrome Seriously
According to a recent analysis, it could plausibly happen in just over a decade. That would not be great.
New York Giants Just Opened Up Some More Cap Space
The New York Giants just made a move to open up some more cap space.
Corktown pizzeria Grandma Bob’s to expand to West Village
Corktown spot Grandma Bob’s Pizza is expanding to a second location, taking over the West Village space vacated by Marrow.
Federal Employees Face 10.9% Increase in Health Premiums as Open Season Dates Announced
Federal employees will pay higher prices for health insurance in 2027. On average, federal employees enrolled in the Federal Employees Health Benefits Program (FEHB) will pay 10.9 percent more toward their premiums in 2027, marking the third straight year of double-digit increases in the employe
Manchester aerospace company expands casting business with new overseas acquisition
Pursuit announced it closed on the deal to buy Creasey Castings in August, the company’s sixth acquisition since 2023.
Business Strategy: Oklahoma aerospace is entering its next chapter
Kenton Tsoodle argues Oklahoma can build on its aerospace legacy as autonomous aircraft, advanced air mobility and other technologies reshape the industry.
NASA’s Webb Captures Commotion From Nebula’s Stellar Jets
A cauldron of cosmic creation is being revealed in a new image from NASA’s James Webb Space Telescope. Webb has unveiled numerous stars formerly hidden by
Compass Datacenters Funds New Community Wellness Space at Hoffman Estates Health and Human Services
$50,000 investment will create the department's first purpose-built room for group therapy, workshops and community programming Compass Datacenters is funding...
Baltimore’s small business owners want the city to codify more protections
Zehbras CrossFit is the thriving, Black-owned, affordable, and accessible fitness space owner and CrossFit coach Jeanelle Spencer long wanted to bring to Baltimore’s Black Butterfly. On any given weekday afternoon, barbells slam onto rubber mats as Spencer’s neighbors in Waverly cycle through burpees, pull-ups, squats, and more in the small gym at 3302 Greenmount Avenue. […]
A new business lands in Downtown Pelham, a space focused on women
The City of Pelham welcomed a new business in Downtown, She So Fancy 1 Stop Shop Boutique.
Exclusive Warhammer 40,000: Dawn of War 4 Space Marine Screenshots and Interview With Creative Director Jan Theysen
In this exclusive interview with director Jan Theysen, we go into detail on how the Space Marines actually work in Warhammer 40,000: Dawn of War 4.
Industry Insights: Q&A with Estée Lauder’s SVP of Global Clinical, Consumer Sciences on One-of-a-Kind Complexion Research
“A shade can be technically close to a person’s skin tone and still not look completely natural in every situation.”
New York Giants rework Chauncey Golston's contract
The New York Giants have adjusted DL Chauncey Golston's contract to create additional salary cap space in Week 5.
Can taking dead military satellites out of orbit become a business?
Can taking dead military satellites out of orbit become a business?
Francis Halzen wins Nobel Prize in physics for work on high-energy neutrinos from space
The 82-year-old scientist, originally from Belgium, is affiliated with the University of Wisconsin–Madison. His research into capturing neutrinos at the South Pole dates back to the 1980s.
'Ghost particles' from space telescope wins 2026 Nobel Prize in Physics
Belgian physicist Prof Francis Halzen has won for his pioneering work on an observatory that detects particles from space.
Las Vegas Arts District business pushes for safe space for teens after 15-year-old dies in shooting
Advocates call for youth spaces after deadly First Friday shooting
Las Vegas Arts District business pushes for safe space for teens after 15-year-old dies in shooting
Advocates call for youth spaces after deadly First Friday shooting
Las Vegas Arts District business pushes for safe space for teens after 15-year-old dies in shooting
Advocates call for youth spaces after deadly First Friday shooting
Las Vegas Arts District business pushes for safe space for teens after 15-year-old dies in shooting
Advocates call for youth spaces after deadly First Friday shooting
Las Vegas Arts District business pushes for safe space for teens after 15-year-old dies in shooting
Advocates call for youth spaces after deadly First Friday shooting
Las Vegas Arts District business pushes for safe space for teens after 15-year-old dies in shooting
Advocates call for youth spaces after deadly First Friday shooting
Las Vegas Arts District business pushes for safe space for teens after 15-year-old dies in shooting
Advocates call for youth spaces after deadly First Friday shooting
Las Vegas Arts District business pushes for safe space for teens after 15-year-old dies in shooting
Advocates call for youth spaces after deadly First Friday shooting
Las Vegas Arts District business pushes for safe space for teens after 15-year-old dies in shooting
Advocates call for youth spaces after deadly First Friday shooting
Las Vegas Arts District business pushes for safe space for teens after 15-year-old dies in shooting
Advocates call for youth spaces after deadly First Friday shooting
Las Vegas Arts District business pushes for safe space for teens after 15-year-old dies in shooting
Advocates call for youth spaces after deadly First Friday shooting
Arts District business pushes for safe space for teens after 15-year-old’s shooting death at First F
Experts say the shooting death of a teenager in the Arts District is shining a light on the growing issue of youth violence.
Arts District business pushes for safe space for teens after 15-year-old’s shooting death at First F
Experts say the shooting death of a teenager in the Arts District is shining a light on the growing issue of youth violence.
Arts District business pushes for safe space for teens after 15-year-old’s shooting death at First F
Experts say the shooting death of a teenager in the Arts District is shining a light on the growing issue of youth violence.
Arts District business pushes for safe space for teens after 15-year-old’s shooting death at First F
Experts say the shooting death of a teenager in the Arts District is shining a light on the growing issue of youth violence.
Arts District business pushes for safe space for teens after 15-year-old’s shooting death at First F
Experts say the shooting death of a teenager in the Arts District is shining a light on the growing issue of youth violence.
Arts District business pushes for safe space for teens after 15-year-old’s shooting death at First F
Experts say the shooting death of a teenager in the Arts District is shining a light on the growing issue of youth violence.
Arts District business pushes for safe space for teens after 15-year-old’s shooting death at First F
Experts say the shooting death of a teenager in the Arts District is shining a light on the growing issue of youth violence.
Arts District business pushes for safe space for teens after 15-year-old’s shooting death at First F
Experts say the shooting death of a teenager in the Arts District is shining a light on the growing issue of youth violence.
Drake London paces Atlanta's passing attack in Week 4
Drake London led the team in both receptions and receiving yards against the New Orleans Saints on Monday night.
Apple Announces iPhone Duo Apps Can Now Be Submitted to App Store
Apple today announced that apps optimized for the iPhone Duo can now be submitted for App Store approval, ahead of the foldable device launching on Friday, October 23. While existing App Store apps will automatically run on the iPhone Duo, only apps built with the iOS 27.1 SDK or later can dynamically resize to fill the entire space of the inner display, whereas unoptimized apps will have black borders.
Elon Musk regains trillionaire status with SpaceX stock rise
Elon Musk is once again a trillionaire, a title he initially held in June after SpaceX's blockbuster IPO.
A Florida university focuses on space medicine to train future astronaut healthcare providers
A university is expanding its space medicine program to train future physicians to care for astronauts before, during, and after space missions.
Massachusetts Governor Urges No Vote on Cannabis Prohibition Measure
Gov. Maura Healey said she opposes Question 8, a ballot measure that aims to wipe out the state’s adult-use legalization laws.
NBA Trade Idea Sends Mavericks Player, Hawks Player to Pacers
This NBA trade idea sends a Dallas Mavericks player and an Atlanta Hawks player to the Indiana Pacers.
Nutritional countermeasures to spaceflight studied at URI
KINGSTON, R.I. – Oct. 5, 2026 – As humans spend longer periods of time in outer space and venture further from Earth, it’s increasingly important for scientists to learn how varied gravity levels affect muscle function and muscle loss, and how those effects can be counteracted or minimized. Theodoros Pavlidis, a second-year doctoral student who […]
Eurozone business activity grows at fastest pace in 41 months in September
Private sector growth accelerates as demand improves, while input costs, selling prices rise at fastest rates since May | Anadolu
Building something with your hands — and a career
MakerSpace NYC is one of at least 2,000 community workshops across the country.
‘An anchor’: Oakshire fans celebrate, grieve as business prepares to shut down
Oakshire Public House has been a gathering space in the Whiteaker neighborhood since 2013 and holds many individual and community memories. Oakshire as a company is closing, but it plans to transition the Public House to a new company in the next two months, keeping the location open through the process.
Are aliens real? Here’s what science can and can’t prove
Some scientists believe the sheer number of stars, planets and potentially habitable environments in space makes extraterrestrial life plausible. But plausibility is not proof. Despite decades of sear...
Mac Users Reclaim Storage With New Apple Intelligence Removal Tool
A new open-source tool is making waves in the Mac community by helping users reclaim valuable storage space taken up by Apple's AI models. Called "RemoveMacAI," the tool disables Apple Intelligence on macOS 27, removes its downloaded models, and prevents them from being downloaded again. In macOS 27, Apple removed the toggle to disable Apple Intelligence wholesale, and simply disabling individual features doesn't remove the models from your Mac's drive.
WISeSat.Space Completes Business Combination and Begins Nasdaq Trading
WISeSat.Space has completed its business combination with Columbus Acquisition Corp. and started trading on Nasdaq as SAIQ.
Yale School of Medicine On the Science of Childhood Anxiety, Say, Anxiety Disorders Are the Most Common Mental Health Challenges In Youth
Credit: Matt Bradbury October 5, 2026 - By Isabella Backman - Anxiety disorders are the most common mental health challenges in youth. Left untreated, they can disrupt the lives of both children and their families. The good news is that with intervention, most children will overcome these conditions. Across Yale School of Medicine, scientists are working to understand anxiety at every level, from common anxious behaviors to molecular biomarkers in the brain. They are using their findings to develop and disseminate new evidence-based treatments for childhood anxiety. Today, the go-to treatment for childhood anxiety disorders is cognitive behavioral therapy (CBT). This is a form of psychotherapy that teaches children skills for confronting anxious thoughts and helps them practice managing situations that cause anxiety. While it is the gold-standard treatment backed by considerable scientific evidence, up to 50% of children will not see sufficient benefit from CBT alone. Wendy Silverman, PhD, Alfred A. Messer Professor in the Child Study Center, co-directs the Anxiety and Mood Disorders Program alongside Eli Lebowitz, PhD, associate professor in the Child Study Center. One of their main interests is learning how to improve outcomes beyond CBT. “We’re developing cutting-edge, research-based knowledge that can reduce the suffering that anxiety causes children and their families,” says Silverman. Changing parent behavior YSM experts are investigating how to improve CBT outcomes for children by involving the parents. Silverman’s research has uncovered two main components of parent intervention that improve childhood anxiety: not enabling children to completely avoid the things that make them anxious and taking steps to enhance their autonomy. Parents may unintentionally reinforce their child’s anxiety by allowing them to avoid what makes them anxious. They also may unintentionally limit the children’s sense of autonomy by being overly intrusive. “One of the things that we take pride in is that we’ve focused on trying to understand what parents need to do, and to test our ideas and see if changing the parents’ behaviors is enhancing the effects of CBT,” Silverman says. “Our findings thus far suggest that they do." As much as CBT can be helpful, it can also be challenging to get one’s child to do the necessary steps for CBT to work. This is one important reason why Lebowitz created a novel intervention program for parents named Supportive Parenting for Anxious Childhood Emotions (SPACE). Existing intervention programs often teach parents to act as therapists for their child, such as training them on how to practice breathing exercises. “It makes sense, but this doesn’t work very well in practice,” says Lebowitz. “And part of the reason, I think, is that it’s not easy to get your kid to do things, especially if they’re not excited about doing it.” SPACE is unique because it focuses entirely on parent involvement and changing parental behavior—children are not involved in the sessions. For example, parents learn how to use supportive messages that convey confidence that their child can tolerate and manage distress. “It might sound like a parent saying to a child, ‘I get that this is really hard for you, but I know that you can handle it,’” Lebowitz says. The program also works with parents to identify the ways in which they are accommodating anxious behaviors. “We’ll pick one thing that parents are doing that is an accommodation and help them make a detailed plan for how they’re going to change that,” Lebowitz explains. Treating Anxiety in Children and Adolescents Much of the existing research on SPACE has focused on parents of children under age 14. Ongoing studies are now exploring its use with parents of older teens. “Both anxiety and accommodation can interfere with normative developmental shifts during the teen years, including increased autonomy and individuation from parents,” says Rebecca Etkin, PhD, associate research scientist in the Child Study Center. “In this sense, SPACE may be particularly well-suited for anxious teens and their parents. We want to see whether it is effective during this distinct developmental window.” Unfortunately, many families in need of CBT face barriers, including limited availability of services and geographic constraints. One way to improve access is digital interventions. Silverman and her team are developing an evidence-based digitized intervention program for parents that they can access directly from their computer or smart phone. “The work we’re doing will be one of the very few parent interventions that is digitized and importantly tested for effectiveness,” she says. Creating interventions for anxiety-related challenges Silverman and Lebowitz recently received a generous gift to develop and test other interventions that help parents reduce other child anxiety-related behavioral and emotional difficulties, such as restrictive eating and unexplained somatic symptoms. One of these projects in particular focuses on understanding the risks of social media and its potential benefits, including offering a sense of connection. “A lot of research has focused on the idea that social media is harmful and the less of it the better,” says Lebowitz. “But we actually see is that this is not quite right—there are negatives, but there are also positives. So, we’re trying to get a little bit more nuanced of a picture.” The team is working with teens with social anxiety and their parents over an extended period to better understand their social media habits and how their anxiety levels affect engagement with different platforms. The teens will answer questions sent to an app on their phones about mood and social media usage in an effort to capture emotional responses as they unfold. “We hope to develop interventions that can help make the best of social media while protecting against the more problematic effects,” Lebowitz says. The brain’s role in anxiety Researchers are also testing therapies to address anxiety at the neurological and molecular levels. In collaboration with Dylan Gee, PhD, professor of psychology in Yale's Faculty of Arts and Sciences, and Hilary Blumberg, MD, John and Hope Furth Professor of Psychiatric Neuroscience at Yale School of Medicine, Lebowitz and Silverman are using brain imaging to identify changes in a child’s brain before and after parents enroll in SPACE. In one study, children viewed anxiety-inducing images while undergoing magnetic resonance imaging (MRI); the researchers conducted scans with and without the children’s parents nearby. Before SPACE, children’s brains were better able to activate the regulatory circuitry needed to turn off an anxious response when their parents were nearby. But after SPACE, children could activate this circuitry even without the parent around. “As parents work on gradually reducing some of their accommodations, you can see a child get better at regulating their own fear system in the brain,” Lebowitz says. “It’s remarkable.” Research into the molecular underpinnings of anxiety can also inform new childhood anxiety treatments. In a recent study, Lebowitz, Silverman, and Flora Vaccarino, MD, Harris Professor in the Child Study Center, discovered that a protein known as fibroblast growth factor 2 (FGF2) could be protective from the toxic effects of stress. FGF2 levels in children and their parents were linked to the children’s risk of developing anxiety and depression, the study showed. The findings could help explain why some children who are exposed to early life trauma such as poverty or abuse are more prone to developing mental health disorders. And FGF2 could be a target for treatment. “This is very novel because it starts to give a clue to what is the molecular chain that connects those lived experiences to the actual psychological outcomes,” Lebowitz says. New ways to study and treat childhood anxiety Michael Crowley, PhD, associate professor in the Child Study Center, collaborates with Silverman and Lebowitz to study the role that attention plays in development and maintenance of childhood anxiety. There is a large body of research that shows that anxious children, like anxious adults, are prone to focus on threatening stimuli such as angry faces compared with neutral faces. This has led to innovative interventions that involve attention retraining. The idea is that if experts train children to look away from threatening stimuli, it may reduce their anxiety—especially children with social anxiety who are most prone to attend to threats. The researchers have just completed a clinical trial for attention retraining with 10- to 14-year-olds with social anxiety disorders and are currently analyzing the findings. Besides this innovative attention retraining research, as Crowly notes, “I like to design tasks that are engaging to kids,” Crowley says. “My goal is to assess something without the kids knowing what we are assessing.” With this goal in mind, Crowley has created a virtual game, named Boom, to study threat processing in children with anxiety disorders. The game is similar to that of hot potato—the child and three digital players take turns virtually passing a ball to each other’s gloves. At some point, the ball turns into a bomb, and as the bomb lands in each player’s glove, the outline of the glove turns yellow. The goal is to avoid having the bomb go off in your glove. What isn’t obvious is that the game is designed to measure different types of threatening stimuli, both ambiguous and direct. In the game, the direct threat occurs as the bomb is traveling towards your glove. The ambiguous threat is the yellow outlined glove as it is unknown where the bomb will travel next. While children play the game, Crowley’s team measures their brain activity using electroencephalography (EEG). The researchers have discovered that in kids with anxiety, the brain reacts more strongly to ambiguous threats than it does in their peers, but less strongly to direct threats. They believe that the initial abnormally large brain response to not knowing where the bomb is going impairs the brain's ability to properly respond when the threat is actually traveling the child’s way. “The brains of children with anxiety are unable to differentiate between threats you need to do something about and those that are not your problem.” Michael Crowley, PhD, develops innovative games for studying anxiety in children and adolescents.Credit: Matt Bradbury Based on these insights, Crowley hopes to study whether interventions like attention training could restore appropriate threat processing. Crowley’s team is also working on a test called the Balloon Risk Avoidance Task, which evaluates risk-taking and avoidance behaviors. It features a digital balloon that is full of air and about to burst. Kids have six seconds to let air out of the balloon. The more air they let out, the less risk they face that the balloon will pop. But at the same time, the balloon becomes less valuable as it deflates. “The more air you keep in the balloon, the more points you get,” Crowley explains. So far, the researchers have found that when the balloons pop unexpectedly, teens with social anxiety show distinct brain responses. Studying these responses can help psychologists understand the underlying pathways driving the various manifestations of anxiety. The genetics of anxiety When Thomas Fernandez, MD, associate professor in the Child Study Center and of psychiatry, was still in training, there was a lot of excitement about understanding the genetics associated with autism spectrum disorder. Since then, scientists have identified around 250 genes associated with autism. The genetic contribution to anxiety disorders, on the other hand, has historically received less attention. Anxiety is less heritable than autism, but the genetic contribution for anxiety disorders that emerge in childhood may be higher than for anxiety disorders overall. While scientists estimate the heritability of anxiety disorders in general to be around 30% to 50%, some studies suggest higher heritability for certain childhood-onset anxiety presentations. “I saw firsthand how researchers in the field went about finding vulnerability genes for autism,” Fernandez says. “So, we’re using a very similar playbook for childhood anxiety.” “I saw firsthand how researchers in the field went about finding vulnerability genes for autism. So, we’re using a very similar playbook for childhood anxiety.” Thomas Fernandez, MD Associate Professor In the Child Study Center and in Psychiatry Now, Fernandez and Emily Olfson, MD, PhD, assistant professor in the Child Study Center, are studying children and their parents to identify genetic changes that are present in the child but not the parents, known as “de novo mutations.” “All of us have some de novo mutations—maybe about 50 to 100 sprinkled throughout the genome,” Olfson says. “But when they occur within the coding regions of genes, they can be really disruptive.” Previous research shows that people with autism have higher rates of damaging de novo mutations than the general population. In 2022, Olfson, Lebowitz, Silverman, and Fernandez published a study on 68 children and their families that found that children with anxiety had similarly high levels of these mutations. Studying de novo mutations can help point the researchers to where they should be looking for genes associated with anxiety. “The end game is using the genes to steer us toward the right part of biology that we can then target to come up with better treatments,” Fernandez says. Building on those findings, the team is now studying more families to better understand how these de novo mutations, along with other genetic and environmental factors, shape pediatric anxiety disorders. They recently received a National Institutes of Health grant to enroll 750 new families over the next five years. Olfson is the principal investigator, with co-investigators Lebowitz, Fernandez, Silverman, and Shuangge Steven Ma, PhD, department chair and professor of biostatistics at Yale School of Public Health. Neurodevelopment, Risk Genes, and Mental Health Conditions - The Olfson Lab Joel Gelernter, MD, Foundations Fund Professor of Psychiatry, is interested in how different anxiety disorders differ genomically. “We are studying social phobia, panic disorder, and generalized anxiety disorder, working to understand why people differ in their risk to these specific anxiety disorders and evaluating various risk factors,” he says. Gelernter was recently involved in one of the largest studies to date of the genomics underlying anxiety disorder. The study included around 122,000 people with anxiety disorders and around 730,000 without. It found that some genetic differences associated with anxiety were linked to signaling that helps reduce overactivity in the nervous system. Many anxiety medications available today work by targeting this process. “It’s nice when the biology that you get out of a large genome-wide study ratifies things that we already know because that can help increase confidence in further findings from the study,” Gelernter says. Uncovering the neurobiology of psychiatric disorders John Krystal, MD, Robert L. McNeil, Jr. Professor of Translational Research and chair of the Department of Psychiatry, is interested in the neurobiology of psychiatric disorders, including post-traumatic stress disorder (PTSD), of which anxiety is a major symptom. In the late 1980s, Krystal’s team discovered that the drug yohimbine activated symptoms in patients with PTSD. “This was the first time we could link a specific biological mechanism to the symptoms of PTSD,” Krystal says. At the time, he adds, this finding was highly controversial. “A lot of people felt that PTSD was a purely psychological syndrome that didn’t have an underlying biology.” Since then, Krystal has dived deep into understanding the neurobiology of PTSD to learn how to better treat it. His team is evaluating the use of ketamine and psychedelics. These would be among the first treatments to be developed specifically for PTSD. They may also be applicable for other disorders including anxiety disorders, Krystal adds. An important gap in PTSD treatment is the absence of biological tests that inform how to best help patients manage their PTSD symptoms. A doctor doesn’t diagnose cancer based on how they feel. Rather, they use tests of the biology of the cancer to determine the best course of treatment. “And we can’t do that in any psychiatric disorder other than Alzheimer’s disease,” Krystal says. “But now we are building a foundation for this approach to the treatment of anxiety disorders for the first time.” Source: Yale School of Medicine
NYC’s office recovery becomes a competition for talent
JLL’s Peter Riguardi explains how talent, AI growth and demand for premium space are reshaping New York City’s office market.
Euro zone business growth hits over 3-1/2-year high despite inflation worries, PMI shows
BENGALURU, Oct 5 (Reuters) - Euro zone business activity expanded at its fastest pace in nearly 3-1/2 years in September as demand remained strong despite inflation worries stemming from the Middle East war, according to a private survey which also showed resurgent price pressures.
Euro zone business growth hits over 3-1/2-year high despite inflation worries, PMI shows
By Indradip Ghosh BENGALURU, Oct 5 (Reuters) - Euro zone business activity expanded at its fastest pace in nearly 3-1/2 years in September as demand remained strong despite inflation worries stemming from the Middle East war, according to a private su...
Spain services growth accelerates despite cost surge, PMI shows
Oct 5 (Reuters) - The expansion in Spain's service sector picked up pace in September as increased demand lifted activity despite a surge in operating expenses, a business survey showed