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Dopant-localized mechanoluminescence in simple oxides
Light: Science & Applications - Dopant-localized mechanoluminescence in simple oxides
Mental health as both outcome and determinant in climate adaptation
Nature Climate Change - Mental health should not be viewed solely as a passive outcome of climate adaptation. Rather, it serves as a key determinant of cognitive capacity and shapes the...
Evaluating the robustness and readiness of large frontier models in health AI applications
Nature Medicine - Adversarial evaluation of leading AI models uncovers gaps between benchmark success and robustness, highlighting limitations in current health AI benchmarks and their ability to...
Making Our Own Luck
We are cross-posting a piece that former NIH official Kris Willis wrote for Macroscience. Kris is now the President and Founder of the Woodley Park Institute, for which I’m a board member. Picking winners or hedging bets? Federal science agencies have long wrestled with the question of how to ensure their billions of dollars of grants and contracts result in maximum benefits for Americans. On the surface, it might seem that a goal-oriented, interventionist style of management would be the best policy: prioritize our most pressing problems and distribute funding accordingly.This top-down strategy creates a unique hazard, though: bad choices can send resources in the wrong direction, resulting in slow progress that impedes the delivery of tangible benefits to citizens. Moreover, if decision makers pursue an applied advance when the underlying scientific principles remain poorly understood, they risk costly failures and a loss of support for the research enterprise at large. Examples include Nixon’s 1971 War on Cancer, undertaken on the premise that a cure could be achieved in less than a decade, the drive to build an operational commercial fusion plant by the mid-1990s, and the National Plan to Address Alzheimer’s Disease, which failed to produce the effective treatments and prevention strategies promised by 2025. The contrasting laissez-faire approach is to hedge your bets. If the path to an advance is impossible to predict, then the wisest choice might be to distribute funding to as widely as possible. The main risk of this strategy is that spreading funding thinly may limit the resources available to the most promising research, resulting in the same negative outcomes as the interventionist approach: limited support for the most promising topics, slow progress, and delayed returns. In reality, at science agencies like the National Science Foundation and National Institutes of Health, program managers navigate between these two extremes, setting some funds aside to target high-priority areas and using the rest to cover the widest possible range of meritorious proposals. This middle path seems like the most rational way to proceed, but it still requires making choices. How much should be set aside for high priority topics? What should those topics be? How should we define merit? Expert opinion can provide a helpful guide, but leading experts can have remarkably different opinions about what matters and what should be prioritized. Moreover, experts and administrators alike can be risk averse, giving an edge to high-profile, well-established concepts. What’s really needed is a data-driven framework to help guide decision-making, one that doesn’t simply repackage prestige or incumbency. Recognizing breakthroughs years in advance Many breakthroughs fail to attract funding or recognition at the earliest stages of development. Katalin Karikó, for example, spent years struggling to win grants for work on mRNA that would eventually win her and Drew Weissman a Nobel Prize. Similar stories can be told about Jim Allison’s groundbreaking studies leading to the development of cancer immunotherapy, Stan Pruisner’s demonstration that prions can self-replicate without DNA, or Robin Warren and Barry Marshall’s proof that Helicobacter pylori, not stress, causes ulcers. Yet at some point, the scientific community recognizes and responds to transformative breakthroughs like these. How does that change happen? And what if science funders could identify the areas that are on the cusp of a breakthrough? Those questions led my collaborators and me to study how scientists responded to past breakthroughs. Based on patterns in that data, we developed a means of predicting future breakthroughs, using biomedicine as a proof of concept. It’s worth taking a moment to describe how our approach works. Briefly, our prediction process begins by grouping the 18 million or so peer-reviewed papers in PubMed, the authoritative database of biomedical research, into roughly 50,000 unique topics. A small subset of these topics are so widely acclaimed as breakthroughs that they have been recognized with a major prize like a Nobel or a Lasker Award. We theorized that studying the development of these outliers over time, especially before they gained acclaim, was the key to identifying future instances of them. After defining topics, we chose 21 representative breakthroughs and asked what they looked like before they won prestigious prizes. To answer that question, we re-ran our topic-mapping algorithm repeatedly, winding back the clock one year each time, stringing together the years to follow the progress of each field as it grew and advanced. We found that in each case, the years leading up to a discovery followed a pattern: a burst of papers on a new, rapidly evolving topic, many of which quickly became influential. These characteristics—the percent of papers that are new, the percentage of papers that are brought in from other topics, and the influence of each individual paper—can all be measured separately for any given topic. Together, they act as a predictive signal that is detectable an average of five years before a transformative discovery is made, and up to thirty years before the discovery receives a major prize. Scanning the current research landscape for topics that display this signal allows us to predict what work will likely produce a future breakthrough. Each year we analyzed includes four or five signals, a number that appears to have remained constant across a twenty year time frame. In their classic work on the sociology of science, Bruno Latour and Steve Woolgar established that the desire to participate in a major discovery is an important motivator for scientists as they consider whether they should take up (or abandon) a research problem. Although further work is needed, the simplest explanation for our results is that this behavior is widespread enough to detect at scale. A foundational advance, or something like it, draws the attention of scientists and causes them to change the direction of their research. They vote with their feet, staking their own reputation and careers by publishing on and citing the new idea. That upswell of interest is the foundation of our breakthrough signal. What kind of research does our model identify as a breakthrough? After building a model based on the patterns in our 21 preselected breakthroughs, we tested it by identifying all early signals of discovery from 1994 through 1997. Of the 18 signals we found in that time period, 17 can be traced forward in time to a breakthrough. Examples include super-resolution fluorescence microscopy (see the image above), the directed evolution of proteins and enzymes (Chemistry Nobel, 2018), and sequencing the human genome (National Medal of Science, 2008). The discovery of the role of leptin signaling in obesity is a particularly interesting case study. Around 1950, scientists noticed the existence of a type of lab mouse that suffered from a unique inherited form of obesity. When given the freedom to choose their own diet, these mice ate more than normal and preferred food that was high in fat. Researchers had few clues as to why the animals overate; early experiments pointed to the existence of a soluble ob factor found circulating in the bloodstream that regulated appetite, but its identity was unknown. In 1994, Jeffrey Friedman and colleagues identified and sequenced the ob gene, noting that the protein it encoded appeared to fit the profile of a circulating factor. A year later, a trio of high-profile publications demonstrated that ob was a hormone that regulated body weight and fat deposition by regulating appetite. One of these was co-authored by Friedman, who christened it leptin from the ancient Greek word for thin. Using our model, the data from 1996 make it clear this advance would become a breakthrough. Scientists had flocked to study the biology of the new hormone, generating the flurry of new papers and citations required to produce a signal. One of these demonstrated that serum leptin concentrations reflected the amount of adipose tissue in the human body, providing clinical validation of the earlier mouse studies. Before the identification of leptin, scientists were unable to point to a specific molecule that controlled appetite and adiposity, so that it was impossible to rule out non-physiological causes of obesity; its characterization fundamentally changed our concept of weight gain. In 2010, Friedman and fellow pioneer Douglas Coleman were awarded a Lasker for the discovery. Our work also identifies breakthroughs in clinical practice and behavioral and social sciences, even though these areas are less likely to draw the attention of major prize committees. One example that falls into this category is the introduction of endovascular aneurysm repair, a minimally invasive surgical procedure for the treatment of abdominal aortic aneurysm, a leading cause of death among Americans over the age of 65. Relative to the previous standard of care, it reduces in-hospital mortality by almost four-fold. In 2017, Timothy Chuter received the American College of Surgeons’ prestigious Jacobsen Innovation award for his multiple refinements to the technique. Another under-recognized breakthrough identified by our model is the development of standardized survey instruments to assess the quality of life for HIV+ patients. The antiretroviral cocktails introduced in the mid-1990s reduced AIDS mortality, but treatment came with serious side effects. The new evaluations showed that patients whose disease progressed had worse physical functioning than Americans with other chronic diseases, while those who were asymptomatic maintained a health-related quality of life on par with the overall US population. This evidence made it possible for patients and activists to argue that even in the absence of a total cure, and in spite of the side effects, alleviation of symptoms was a worthwhile priority for clinicians. My colleagues and I have failed to identify any significant recognition for the physicians and health policy experts who pioneered this advance, although in 2016, researchers called for the World Health Organization to set targets for good health-related quality of life as part of its framework to end the AIDS pandemic. From forecasting to funding How should science funders use our predictions? Any serious discussion of what we should do with this new capability needs to begin with an understanding of its limitations. We can’t (and shouldn’t) invest all of our resources in the small number of topics predicted to produce breakthroughs. Innovative new fields are born from existing ones; they rarely arise de novo. If funders don’t maintain a diverse portfolio, the breakthroughs of tomorrow will have no antecedents. Think of this as eating the seed corn, or killing the goose that lays the golden egg. There are also multiple goals of funding beyond basic scientific discovery, including translating discoveries into clinical practice, developing new technologies, supporting economic development, and training new scientists. The investments needed to accomplish these goals are likely different from those required to support emerging breakthroughs. Finally, we must be aware that we may not capture every instance of a breakthrough. The concept is fuzzy, and not every significant discovery is recognized with a major award. Further, breakthroughs are rare, meaning that our dataset is, by necessity, small. This makes formal estimates of accuracy challenging. Although our overall success rate appears to be high, any one signal may turn out to be a false positive. We found one apparent example: the development of the third generation COX-2 inhibitors, Vioxx and Celebrex, which were much celebrated in the early 2000s as effective but non-addictive pain relievers, meets all the algorithmic criteria of a breakthrough. Five years after it received FDA approval, researchers demonstrated that Vioxx was associated with serious cardiovascular complications, and the manufacturer voluntarily pulled the drug from the market. Celebrex remains available, although like other NSAIDs, it carries an FDA warning for increased cardiovascular risk. Decision makers who were overly focused on the breakthrough potential of this research might have wasted substantial resources nurturing an area that ultimately proved to be a failure—but so would those who relied on expert opinion at the time. That said, the potential benefits of funding the next mRNA vaccine or cancer immunotherapy years earlier than we might have are large. When we can’t assume the outcome of an action, it’s worth conducting an experiment. Can targeted support for areas that are poised to produce a breakthrough increase the return on scientific investment without cannibalizing future advances? With the necessary administrative infrastructure in place, conducting this experiment would be straightforward. First, identify all the breakthrough signals between 2018 and 2023, select half at random, and commit to a decade of investment. For biomedicine, a six year window should yield about 30 topics with the potential to produce a breakthrough. Providing strong support to half of these might be accomplished for $300 million a year. That’s roughly half of the recent annual budget of the NIH Common Fund or around 20% of the fiscal year 2025 budget for ARPA-H. After five years, then again at ten, compare to see which group — the one that was actively managed, or the control — produced more breakthroughs, and on what timescale. Although we used biomedicine as an example, the same experiment could just as well be run for physics, materials science, or any other discipline. Any attempt to undertake such an experiment should keep three points top of mind. First, we can predict the topic of future breakthroughs, but the people and vision for how to move the work forward are still important. In practice, this means success requires active program managers with the expertise to develop the science and the authority to do so, including by recruiting investigators. Second, we would be wise to learn from the failures of past attempts to fund transformative research. High among these are funding modestly repackaged work, confusing the genuinely novel with the merely unfamiliar, and relying too much on incumbent investigators. All of these risks can be mitigated by thoroughly and intelligently integrating high quality data into portfolio management. Finally, we need to have patience. Even with strong funding support, producing a breakthrough takes time. If supporting breakthroughs is the best way to nurture the birth of new fields, we also need to accurately describe and properly manage the other two stages, so that we invest wisely throughout the productive lifetime of ideas and divest once they reach the point of diminishing returns. We would benefit from more study of all of these phases, especially the transition from one to another. More research could answer questions like: When does a breakthrough become an established field? How do the availability of funding, the size and characteristics of the available workforce, and the accumulation of evidence that disagrees with prevailing models affect a field’s decline? Exactly how do old ideas give birth to new ones, and can we speed up the process? The more we understand about the dynamics of scientific progress, the better we can maximize the odds that our curiosity leads to results. I’d call that finding a way to make our own luck.
Multi-wavelength spin dynamics of defects in hexagonal boron nitride
Light: Science & Applications - Different excitation wavelengths strongly influence the spin dynamics and photophysics of single spin defects in hexagonal boron nitride, enabling a threefold...
Patriots Coach Jeremy Springer Announces Engagement To NBC Sports Host Kayla Burton
NBC Sports host Kayla Burton is engaged to an NFL coach. The popular Boston-based sports media personality announced her engagement to New England Patriots special teams coordinator Jeremy Springer. The two announced their big news in a joint Instagram post Monday, sharing photos from the NFL ...
Circulating metabolites at the crossroads of lifestyle and brain health
Nature Aging - Circulating metabolites might provide early insights into brain aging before clinical symptoms appear. Ahmad and colleagues show that specific blood metabolites in midlife are...
Fermented food microbiome: influence on oral and gut microbiota, and human health
Nature Reviews Microbiology - The bioactive compounds and microbial consortia contained in plant-based fermented foods support oral and gut microbiota, host immune function and metabolic...
Multi-omics insights into floral–fruity aroma formation during Pu’er tea fermentation inoculated with a synthetic fungal community
npj Science of Food - Multi-omics insights into floral–fruity aroma formation during Pu’er tea fermentation inoculated with a synthetic fungal community
The growing concentration of national influence in global science
Nature Human Behaviour - This analysis of nearly 240 million scientific papers reveals growing concentration of discursive influence in core, resource-wealthy countries, indicating that a few...
A cloud-based miniscope for neurosurveillance of brain health and disease in freely behaving animals
Nature Methods - A miniscope with cloud-based operation and multicontrast capabilities enables continuous recording of neuronal activity, hemodynamics or cellular dynamics over multiple days. This...
Long-term health risks of e-cigarettes after smoking cessation
Nature Medicine - Real‑world evidence from a nationwide cohort suggests that using electronic cigarettes after smoking cessation may attenuate the benefits of quitting in reducing lung cancer...
Modelling the odor profile of fungal Solid-State Fermentation
npj Science of Food - Modelling the odor profile of fungal Solid-State Fermentation
Smartphones passively monitor heart health
Nature Reviews Electrical Engineering - A study in Nature uses deep learning to passively monitor resting heart rates via front-facing smartphone cameras, yielding highly accurate cardiovascular...
Chronotherapy considerations in lithium treatment for bipolar disorder
Nature Mental Health - In this Perspective, Ray and colleagues review 50 years of studies on the effectiveness and toxicity of lithium and argue that its effects depend on dosing time. They propose...
Testing longitudinal gene–environment interactions
Nature Computational Science - A gene–environment interaction test (SAGELD) is developed to speed up large-scale genome-wide analyses using longitudinal data, facilitating novel discoveries...
A competency framework for digital public health in Europe: an updated scoping review
npj Digital Public Health - A competency framework for digital public health in Europe: an updated scoping review
Team careers in science: formation, composition and success of persistent collaborations
npj Complexity - Team careers in science: formation, composition and success of persistent collaborations
Global multipolarity through the lens of network science and game theory
npj Complexity - The “Theory of Competing Networks”, which integrates network science and game theory, reveals that cooperation is more stable than hierarchy, offering insights into...
A novel belief-degree-based uncertain Tchebycheff norm DEA model for the case study of risks prioritizing in e-business projects
Scientific Reports - A novel belief-degree-based uncertain Tchebycheff norm DEA model for the case study of risks prioritizing in e-business projects
A career of taking biological species for a spin
Nature Reviews Chemistry - Ahead of his 70th birthday, Adriaan (Ad) Bax, Distinguished Investigator at the National Institutes of Health (NIH), spoke about his career in science.
Environmental roots of neonatal health: how social and structural exposures shape early-life outcomes
Pediatric Research - Environmental roots of neonatal health: how social and structural exposures shape early-life outcomes
Facilitators of, barriers to and strategies for health-system guidance implementation: a critical interpretive synthesis
npj Health Systems - Facilitators of, barriers to and strategies for health-system guidance implementation: a critical interpretive synthesis
Science for kids: a melody that mends
Pediatric Research - Science for kids: a melody that mends
A reporting checklist for large language models in behavioural science
Nature Human Behaviour - Large language models offer new opportunities for behavioural science, but their rapid evolution poses challenges for research rigour. We introduce a consensus-based...
Jays Crushed By Orioles
Orioles A Lot Blue. Jays A little. That was less than fun. Everything that mattered happened in the bottom of the fifth and the top of the sixth. The Jays scored two in the top of the fifth. With two out George Springer reached on catcher interference, yet again. They are going to name catcher […]
Lawsuit to be filed against Cincinnati in death of OTR business owner, widow announces
Sarah Heringer announced the wrongful death lawsuit a day before the anniversary of her husband, Patrick Heringer.
Sulfonamide resistance as a global one health challenge
The Journal of Antibiotics - Sulfonamide resistance as a global one health challenge
A century of innovative spirit and an optical scientist’s pursuit
Light: Science & Applications - A century of innovative spirit and an optical scientist’s pursuit
Life’s essential 8 and longevity: the sustained impact of cardiovascular health on mortality from middle age to centenarians
npj Aging - Life’s essential 8 and longevity: the sustained impact of cardiovascular health on mortality from middle age to centenarians
Mapping the avoid-ome: a systematic open-science approach to predictive ADMET
Nature Communications - Mapping the avoid-ome: a systematic open-science approach to predictive ADMET
Acute coronary syndromes across the lifespan of women
npj Cardiovascular Health - Acute coronary syndromes across the lifespan of women
A scoping review of studies on secure messaging through patient portals: persistent challenges and potential solutions
npj Health Systems - A scoping review of studies on secure messaging through patient portals: persistent challenges and potential solutions
Preserving the future of vaccine science in the USA
Nature Microbiology - Vaccines have saved an estimated 154 million lives in 50 years, yet that infrastructure is under threat. We highlight the global impact of vaccine scientists who trained in...
Glycerol is a new ally for heat production and bone health
Nature Metabolism - The mechanisms controlling activation of the futile creatine cycle are unknown, calling into question its physiological relevance. In work recently published in Nature, Hussain,...
A framework for longitudinal health AI agents
Nature Health - This Perspective outlines the main components needed to design AI models that can assist individuals in the long-term management of their health, formalizing also the shortcomings...
Axel Springer Revenue Rises 2.6% Following Business Split
The media company said it had a strong start to the year after posting higher revenue—in its first results since splitting into two businesses in April of last year.
Integrating public health into house design
Nature Medicine - Housing is not just a backdrop to health, but a powerful intervention. A study now shows that redesigning the home environment can improve child health outcomes, but success...
Transforming our future by unlocking the power of DNA: the representation of health-related genomic testing in UK news items
European Journal of Human Genetics - Transforming our future by unlocking the power of DNA: the representation of health-related genomic testing in UK news items
Neural representation of action symbols in primate frontal cortex
Nature - A drawing-like task designed to study compositional generalization identifies a specific neural population in the ventral premotor cortex in primates that encodes action symbols.
Modeling context-dependent RNA splicing by deep learning
Nature Computational Science - A framework called HELIX provides a strategy for predicting full-length transcript isoform usage across diverse biological contexts by integrating sequence features...
Photoinduced radical emission from flexible organic crystals
Light: Science & Applications - Photoinduced radical doping strategy enables blue luminescence and elastic bending (>180°) in organic crystals. Confined oxygen radicals and dynamic...
Whoa! Netflix is Sending Narnia Heading to Theaters...What This Means for the Future of Film
(Welcome to the “Most Important Story of the Week”, my bi-weekly strategy column analyzing the most important (but often not buzziest) news story of the last two weeks. I’m the Entertainment Strategy Guy, a former streaming executive who now analyzes business strategy in the entertainment industry. Please subscribe.) Here’s a funny thing about the debate over whether streamers should release their movies in theaters first: Both sides think the other side represents the “conventional wisdom”. If you’ve been reading me for any amount of time, or even just scanned my front page, you know I think movies make more money by having a robust theatrical window compared to going straight-to-streaming. I’ve published thousands of words on this topic. And for years, I felt like I was standing up to a wave of opposition. See, while the “put your films in theaters to make money” take was obvious at any point before 2019, post-streaming revolution, most of the trendy thinkers took the opposite point of view. Big names argued that Netflix putting their film straight-to-streaming (“S-to-S” from here on out) actually made more money. Netflix was “disrupting” theaters, just as they disrupted Blockbuster Video, and since innovation is always good, this too was a great idea. This thinking then leaked into the mainstream business outlets like the Wall Street Journal and Bloomberg. I read many articles whose take boiled down to “Netflix makes tons of money from S-to-S releases” and “theaters were in structural decline” anyways. Covid-19 shutting down theaters and the 2023 strikes shutting down film production seemingly justified this point of view, as the box office struggled to return to 2017-2019 heights. Yet I’ve also read folks arguing the opposite point: the conventional wisdom says to put films in theaters! From some writers’ points of view, “everyone” actually agrees/agreed with my “send your films to theaters” take—especially the stodgy traditional studios—and folks still didn’t understand Netflix’s genius. I feel like, for the last two years, many people have argued this point as if it’s conventional wisdom. You know what? I may have been wrong. At this point, the “S-to-S strategy makes money” might be the minority viewpoint. Especially with the news this month that Netflix will put at least one film—Greta Gerwig’s Narnia film The Magician’s Nephew—in theaters in 2027 for a full 49-day run is big news. So that’s the story of the week, but I’ll also explain why they’re making this move now and why Netflix may not completely embrace theaters, along with other topics, like how I don’t buy Disney’s “super app” strategy, the latest good news out of the unions, my take on the latest attacks against free speech, and a whole lot more. Let’s get started. Subscribe Most Important Story of the Week - Netflix Goes to Theaters! Listen, I promise not to victory lap too hard today. As I just wrote, I’ve argued against sending films straight-to-streaming for—checks calendar—eight years now. Since 2018. Yikes. That’s a long time. And for years, others painted my thinking as “conventional” in that I was standing up for the status quo against trendy, cool disruption. And that’s not cool! But math is math, and I never could make the S-to-S numbers work. The only thing that ever enabled that model was Wall Street’s brief exuberance for it. It seems like the heads of Netflix now agree with me. (There were always rumors that former head of film for Netflix Scott Stuber argued internally for theatrical releases as well.) As they announced: “The Magician’s Nephew_—the first film in a Narnia series of films—will open on 12-Feb-2027, with a 49 day theatrical exclusive run.”_ I’m a little surprised at how little coverage this big change actually got. Credit to Bloomberg for leading with it and Matt Belloni’s The Town for highlighting it with the provocatively titled podcast “Hell Hath Frozen Over”. But after that? Instead of getting as much coverage as, say, the FCC’s latest egregious crackdown on free speech, this news story got crickets. But it’s massively more important for the future business of entertainment. So let’s start with the obvious question… Why Put Your Movies in Theaters? So…why should Netflix put (some!) of their movies in theaters? Well, I’ve already written that in a very, very, very long article from 2022: [ ](https://entertainment.substack.com/p/the-data-is-in-theatrical-films-massively) [ The Data Is In: Theatrical Films Massively Outperform Straight-To-Streaming Films ](https://entertainment.substack.com/p/the-data-is-in-theatrical-films-massively) Entertainment Strategy Guy · April 5, 2023 [ Read full story ](https://entertainment.substack.com/p/the-data-is-in-theatrical-films-massively) To summarize, theatrical runs make much more money, especially blockbusters, because they earn more money per viewing,1 and that helps boost home entertainment sales. Theatrical films also perform as well or better than the streaming-only films. Now, partially this is driven by increased marketing for said films, but said marketing ultimately boosts the awareness of the movies and drives improved streaming and library performance as well. Again, I’ve made this case after reviewing the economic models and streaming data for years. Just last week, Emily Horgan also made the case for kids films! Yes, it is probably conventional wisdom, but that’s also because it’s true! I’d also argue we’ve seen a lot of data in the various studios’ behavior. As I’ve noted before, the more a studio needs to make money, the likelier they are to put films in theaters. As such, Disney, Universal, Warner Bros., Paramount and Sony all send their major films to theaters. Even if they once made a big S-to-S push (*cough* Disney *cough*), they’ve since relented and returned to theaters. The tech companies don’t need to make money, per se, so it took them years to embrace theaters. Apple doesn’t need to make money because it doesn’t disclose their (likely) Quibi-sized losses each year. (They fear bad press more than losing money.) Amazon announced two years ago that they planned to make Amazon-MGM Studios/Prime Video profitable on its own, and guess what? Now they’re putting films in theaters. That leaves Netflix. They’re in between the “no need to make money at all” and the “desperately need to make money to offset linear TV declines”, so they had less pressure to put some films in theaters. Plus, for years, they were the sexy disruptor, and Wall Street rewarded them for that. (Honestly, they still do.) Yet, even Netflix likely saw the money they were leaving on the table (I’ve estimated it at an easy billion dollars before) so they changed their course. I heard one pundit argue that, because Netflix already makes so much money, they don’t need to make more money, which sort of goes against everything I’ve ever learned about business and economics. Again, to be super-nuanced, sending “films to theaters” does not mean EVERY film. TV movies have been a thing for decades. Lifetime films, Hallmark holiday films, Disney Channel Original Movies, and so on, don’t need theatrical runs. But films above a certain budget level (say $25 to 50 million) almost certainly need theaters to maximize their revenue. The Scenarios (with a Dose of Skepticism) Now time for some skepticism: it won’t surprise me at all if Netflix re-changes course. Specifically, Netflix announced that their Narnia film will go to theaters. And I’d bet anything we see KPop Demon Hunters 2: The Huntering2 also goes to theaters, cause it’s the surest hit outside of a Disney animated sequel right now. But how much does Netflix truly commit to theaters? They’ve already tried to emphasize that this is a one-off move. I see three broad scenarios:
Integrated sensing networks for One Health monitoring
Nature Sensors - This Perspective outlines an integrated sensing framework for One Health, linking human, animal and environmental monitoring through connected sensors and AI-driven data fusion to...
Phonon-polaritonic skyrmions: transition from bubble- to Néel-type
Light: Science & Applications - We demonstrate wavelength-tunable surface phonon-polariton skyrmions on silicon carbide membranes. Leveraging strong material dispersion, we experimentally...
Decoding chirality at the nanoscale with momentum-space polarimetry
Light: Science & Applications - Schematic illustration of Fourier-domain Mueller matrix polarimetry probing light-matter interactions in gammadion nanostructures, and enabling extraction of...
Spaceborne snapshot compressive hyperspectral imaging
Light: Science & Applications - We propose and complete the world’s first computational imaging-enabled compact spaceborne snapshot compressive hyperspectral payload, named...
Sustainable science mapping: benchmarking green AI against transformers for cross-disciplinary abstract classification using arXiv
Scientific Reports - Sustainable science mapping: benchmarking green AI against transformers for cross-disciplinary abstract classification using arXiv
Climate change and social health
Nature Human Behaviour - Climate change and social health are deeply interconnected: climate impacts erode social conditions, while social disconnection weakens collective climate action....
The political polarization of health outcomes in the USA
Nature Human Behaviour - Using individual-level medical data and death records, this study finds that conservatives in the USA experienced worse health and higher mortality than liberals during the...
Time matters: circadian genetics and the molecular logic of human health and disease
Nature Reviews Genetics - The circadian clock controls transcriptional and signalling networks across tissues to maintain homeostasis, with pathological consequences to its disruption. Kuo et al....
Network topology of the gut microbiome associates with metabolic health in obesity
Nature Communications - Here, the authors show that microbiome network topology associates with metabolic health across obesity phenotypes, with reduced connectivity in metabolically unhealthy...
Lung Cancer Research Foundation Grants Team Science Award Focused on Understanding and Treating Lung Cancers with HER2 Mutations
/PRNewswire/ -- The Lung Cancer Research Foundation (LCRF) announces the first recipients of its LCRF | Boehringer Ingelheim Team Science Award on Innovative...
Transforming artificial intelligence into artificial wisdom
Nature Mental Health - In this Perspective, the authors discuss reframing digital mental health tools by transforming artificial intelligence into artificial wisdom.
Talking quantum with a 9-year-old
Nature Reviews Physics - Katia Moskvitch shares her experience of launching a quantum computing podcast with her child.
GDP alone cannot measure human progress and well-being
Nature Health - Gross domestic product remains the dominant metric of progress, but new measures such as healthy lifetime income offer policymakers a clearer and more relevant view of well-being.
Smart, hybrid, integrated, and engineered geothermal (SHIEG) systems
npj Thermal Science and Engineering - Geothermal sources can supply clean, sustainable, baseload thermal or electrical energy to fulfill societal demands in diverse climates via various...
Deckbuilding autobattler Samurai Bringer: Rampage announced for PC
Publisher PLAYISM and developer Alphawing have announced Samurai Bringer: Rampage, a deckbuilding autobattler entry in the Bringer series. It will launch for PC via Steam in 2026 with English, Japa…
Quantum topology emerges at near field
Light: Science & Applications - Near-field nanophotonics platform with spin-orbital coupling enables single-photon skyrmions with robust topological structures for high-dimensional quantum...
Environmental and lifestyle drivers of early-onset cancer
Nature Health - Early-onset cancer of many body sites and organ systems is increasing worldwide; this Review outlines the potential causes.
Thymus renaissance poised to boost health and longevity
Nature Biotechnology - Evidence linking thymic function with health and longevity is piling up, and a cluster of biotechnology companies is trying to regenerate the thymus directly or recapitulate...
Translating biodiversity into chemical diversity
Nature Computational Science - DeepSeMS, a transformer-based generative framework, translates biodiversity into chemical diversity by predicting microbial secondary metabolite structures directly...
Direct air capture has substantial health and climate opportunity costs
Communications Sustainability - Renewable energy remains more cost effective for climate and health outcomes than direct air capture except under highly optimistic technology improvements,...
Understanding environmental exposures in early life for lifelong health
Nature Health - Understanding early-life environmental exposures is crucial for protecting lifelong health and should be prioritized in developing exposomics studies and infrastructures worldwide.
Toronto Blue Jays Dodge Bullet With Latest Injury Concern
Blue Jays slugger George Springer has avoided another serious injury after an early exit from a game against the Minnesota Twins on Saturday
Jays Score 8 In The 8th, Beat Twins
Blue Jays 11 Twins 4 Jays did everything they needed to do in the top of the eighth: But there was also bad news, George Springer took a pitch off the, already broken, toe and had to come out of the game. I’d imagine he’ll be back on the IL. I was wrong the Jays […]
Allied health services availability and human milk nutrition among preterm infants
Pediatric Research - Allied health services availability and human milk nutrition among preterm infants
Beyond medication: factors contributing to uncontrolled hypertension from the 2023 Indonesian health survey
Hypertension Research - Beyond medication: factors contributing to uncontrolled hypertension from the 2023 Indonesian health survey
Neonatal extracorporeal membrane oxygenation outcomes according to social determinants of health
Journal of Perinatology - Neonatal extracorporeal membrane oxygenation outcomes according to social determinants of health
While we argue, schizophrenia advances
Nature Mental Health - In this World View, Constanza Morén, a biomedical researcher and daughter of a man with schizophrenia, calls for humility and collaboration to bridge the divide between...
Energy system science must look beyond net zero
Nature Reviews Clean Technology - Energy system models are used to inform decisions about the clean energy transition. Extending the foresight horizons of these models beyond net-zero target dates...
IV fluids recalled over possible contamination—patients face risk of vascular complications
Particulate matter may be present in certain 1-liter containers of B. Braun Medical's Lactated Ringer's Injections. If this enters a patient's circulatory system, it could lead to a series of adverse events.
Priority research questions in global peatland science
Communications Earth & Environment - Global research prioritization for peatland science engaged 467 participants from 54 countries, identifying 50 priority research questions across carbon...
A global survey on trust, digital health literacy and health information quality
Nature Health - An online cross-sectional survey across 30 countries, including 31,000 adults, explores perceptions of quality health information, with respect to source type and inclusion of...
Early attention deficit hyperactivity disorder prediction from longitudinal electronic health records
Nature Mental Health - Using electronic health records from over 140,000 children, the authors developed a neural network model that predicts attention deficit hyperactivity disorder diagnosis...
Incorporation of the National Institute of Health (NIH) sex as a biological variable policy by R01 grant awardees
Communications Medicine - Warden et al. analyze 574 NIH-funded publications (2017–2024) to assess implementation of the Sex as a Biological Variable policy. They find that most studies...
Health insurance and end-of-life healthcare expenditures: evidence from Chinese Longitudinal Healthy Longevity Survey
npj Health Systems - Health insurance and end-of-life healthcare expenditures: evidence from Chinese Longitudinal Healthy Longevity Survey
Blue Jays’ George Springer Replacement Offers 5-Word Response On Health Setback
The Toronto Blue Jays’ outfield veteran revealed that he is still dealing with a scary health situation after treatment.
SQUARE ENIX ANNOUNCES <em>EVERCOLD—</em><br /> LATEST <em>FINAL FANTASY XIV </em>EXPANSION SET FOR<br /> JANUARY 2027
EVANGELION Crossover Alliance Raid and Nintendo Switch 2 Version Revealed; Shadowbringers Expansion Added to Free Trial and More
Topological control of chirality and spin with structured light
Light: Science & Applications - Pancharatnam topological charge drives deterministic spin-orbit interactions in paraxial free space, inducing tunable optical chirality and radial spin...
Impact of extraction methods on Monte Carlo based dietary health risk assessment of potentially harmful elements in edible plants
Scientific Reports - Impact of extraction methods on Monte Carlo based dietary health risk assessment of potentially harmful elements in edible plants
Smoke-free nicotine products can accelerate the end of the smoking epidemic
Nature Health - Increased use of smoke-free nicotine products such as vapes could help to achieve an ambitious global goal of reducing smoking prevalence below 5% by 2040.
TLR/NF-κB activation in vitro as a tool in the assessment of occupational bioaerosol exposure and health risks in wastewater treatment plants
Journal of Exposure Science & Environmental Epidemiology - TLR/NF-κB activation in vitro as a tool in the assessment of occupational bioaerosol exposure and health risks in wastewater...
Dual-comb absolute ranging reaches orbit
Light: Science & Applications - Tianzhou-9 carried an extravehicular dual-comb absolute-ranging payload to Tiangong space station, demonstrating sustained on-orbit kHz-level updates and...
New tools drive scientific discovery: evidence from all nobel-prize and major non-nobel breakthroughs
Humanities and Social Sciences Communications - New tools drive scientific discovery: evidence from all nobel-prize and major non-nobel breakthroughs
Multifunctional ligand engineering for pure-blue halide perovskite nanocrystal LEDs
Light: Science & Applications - Passivation with a bifunctional fluorinated ligand stabilizes mixed-halide perovskite nanocrystals, enabling high-color-purity deep-blue emission...
Workplace wellness and health promotion
In recognition of the role this research plays in UN Sustainable Development Goals 3 and 8, this Collection is open to original research on workplace wellness ...
PREZODE: a global co-designed collaboration for preventing zoonotic emergence
Nature Health - PREZODE is a global One Health initiative, involving scientists, communities, governments and practitioners, to prevent zoonotic epidemics and pandemics.
Three-stage progressive framework for Dongba ancient texts inpainting
npj Heritage Science - Three-stage progressive framework for Dongba ancient texts inpainting
Blue Jays place DH George Springer on injured list with toe fracture, call up Eloy Jiménez
Blue Jays add Silver Slugger winner to replace injured George Springer
Toronto had to find someone new.
The hidden role of education in oral health
British Dental Journal - The hidden role of education in oral health
Pose-based embodied interaction for digital Dunhuang dance heritage
npj Heritage Science - Pose-based embodied interaction for digital Dunhuang dance heritage
Policy mitigation, human drivers and health risks of antibiotics in global aquatic environments
Communications Earth & Environment - Antibiotic contamination in global aquatic environment exhibits significant regional disparities with low-and-middle income countries experiencing higher...
MIT graduate engineering and business programs ranked highly by U.S. News for 2026-27
U.S. News and World Report ranked MIT’s graduate engineering program No. 1 in the country for 2026-27. The MIT Sloan School of Management is ranked as the nation’s No. 6 business school.
Boehringer Partners on Connecticut Science Center STEM Lab » CBIA
Boehringer Ingelheim and the Connecticut Science Center launched an Innovation Lab to advance STEM education in Connecticut.
Investigating the replicability of the social and behavioural sciences
Nature - A large-scale study on the replicability of claims from social and behavioural science journals reports that about half of the results replicate in the same patterns as the original study.
Mapping pesticide mixtures to cancer risk at the country scale with spatial exposomics
Nature Health - Using an integrative spatial Bayesian framework that merges high-resolution environmental pesticide risk modelling with comprehensive cancer registry data, this analysis reveals...
Cardiovascular health in pregnancy according to Life’s Essential 8 score
npj Cardiovascular Health - Cardiovascular health in pregnancy according to Life’s Essential 8 score
Health impacts of indoor air quality
In this Collection, the editors at Communications Health invite submissions that advance understanding of how indoor air quality affects human health across ...