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Results for " Etro " 3,474 found 🔀 AI-powered Shuffle

ESPN Grades Detroit Lions Offseason

ESPN gave the Detroit Lions one of the NFL's highest offseason grades, praising Brad Holmes' work while questioning one major move.

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Jul 2 • 6:33 AM EDT • Sports • sports.yahoo.com
Red Wings Acquire Keegan Kolesar in Trade with Golden Knights

The Detroit Red Wings have acquired forward Keegan Kolesar from the Vegas Golden Knights in exchange for future draft picks.

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Jul 1 • 7:21 PM EDT • Sports • sports.yahoo.com
'Salute to America' at Greenfield Village to start with sold-out DSO performances

"Salute to America," which starts Thursday and runs through Sunday, will feature the DSO's principal conductor leading the concert all four nights.

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Jul 1 • 6:14 PM EDT • Entertainment • yahoo.com
Metro Detroit businesses make adjustments due to extreme heat
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Jul 1 • 5:58 PM EDT • Business • cbsnews.com
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Red Wings Sign Depth Defenseman

The post Red Wings Sign Depth Defenseman appeared first on Detroit Hockey Now. The opening of the NHL’s 2026 Free Agency period has seen the league trying to round out their rosters with […] The post Red Wings Sign Depth Defenseman appeared first on Detroit Hockey Now.

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Jul 1 • 5:00 PM EDT • Sports • sports.yahoo.com
NEW Best In Games Warren: Metro Detroit’s Ultimate Indoor Family Entertainment Center

Located at 28300 Dequindre Road, this massive entertainment destination features everything from an enormous indoor playground and laser tag to go-karts, bowling, arcade games, and even axe throwing…

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Jul 1 • 4:33 PM EDT • Entertainment • littleguidedetroit.com
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Trump's crypto earnings far outpace the businesses he spent decades building

NPR's Scott Detrow talks with Bernard Condon of the AP about how President Trump and his family raked in more than a billion dollars last year through crypto ventures.

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Jul 1 • 4:11 PM EDT • Business • npr.org
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Red Wings Sign Backup Goaltender

The post Red Wings Sign Backup Goaltender appeared first on Detroit Hockey Now. The Detroit Red Wings have added to their goaltending stable with a contract for Daniil Tarasov. Steve Yzerman and Detroit’s […] The post Red Wings Sign Backup Goaltender appeared first on Detroit Hockey Now.

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Jul 1 • 3:55 PM EDT • Sports • sports.yahoo.com
Retrofitted Qatari jet takes flight as Air Force One for Trump's N. Dakota trip

It has luxury features like plush carpets, lie-flat seats, wood paneling and a presidential seal on the seat belts

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Jul 1 • 3:41 PM EDT • Politics • spectrumlocalnews.com
Retrofitted Qatari jet takes flight as Air Force One for Trump's N. Dakota trip

It has luxury features like plush carpets, lie-flat seats, wood paneling and a presidential seal on the seat belts

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Jul 1 • 3:41 PM EDT • Politics • spectrumlocalnews.com
Red Wings Add Goaltending Depth, Sign Daniil Tarasov
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Jul 1 • 3:33 PM EDT • Sports • sports.yahoo.com
Next Metroid Game for Switch 2 Reportedly Leaked in Age Rating From Brazilian Government

The Brazilian government may have leaked the next Metroid game, thanks to an age rating filed through the country’s Ministry of Justice and Public Security.

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Jul 1 • 3:31 PM EDT • Technology • ign.com
Metroid Ravenous For Switch 2 Seemingly Leaked In New Rating

It's certainly believable given the timeline

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Jul 1 • 1:35 PM EDT • Technology • kotaku.com
Rumor: Metroid Ravenous leaked for Nintendo Switch 2

Metroid Ravenous has apparently been leaked for Nintendo Switch 2. A listing for the game supposedly surfaced within Brazil’s Ministry of Justice and Public Security system. The page has already been removed, but not before a screenshot was taken. Here’s a snapshot of the classification: The listing doesn’t provide any specific details about the game. However, the classification indicates 2026...

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Jul 1 • 12:49 PM EDT • Technology • nintendoeverything.com
U-M’s Detroit Neighborhood Entrepreneurs Project leans into AI to support small businesses

In the last 10 years, the program has expanded significantly. In addition to consulting projects, DNEP now offers accounting assistance, community technology support, AI workshops and specialized programming office on helping business owners strengthen their financial and digital skills.

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Jul 1 • 11:26 AM EDT • Business • detroit.umich.edu
John Collins agrees to $51 million contract with Detroit Pistons

The veteran big man strengthens the Pistons' frontline.

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Jul 1 • 8:38 AM EDT • Sports • sports.yahoo.com
Opinion: Michigan’s nonprofits are vital infrastructure, not a nice-to-have

Nonprofits work every day standing at the center of some of the hardest realities of our time.

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Jul 1 • 8:00 AM EDT • Business • crainsdetroit.com
Yankees still falling way behind, still searching after latest loss

This time, Cam Schlittler was roughed up, and the Yankees' lineup once again couldn't mount anything in a 9-3 loss to Detroit, their sixth straight.

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Jul 1 • 4:06 AM EDT • Sports • sports.yahoo.com
Garden City restaurant violations include black mold, unsafe foods

Wayne County health reports show violations at Garden City eateries, including improper food storage, equipment malfunctions and hygiene issues.

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Jul 1 • 12:01 AM EDT • Health • detroitnews.com
Magic find out group pairings for upcoming NBA Cup

The Magic on Tuesday night drew a compelling group for Group Play of the NBA Cup, the league’s fourth-ever in-season tournament. Orlando was placed in East Group A alongside Detroit, Toronto, Milwaukee and Brooklyn. The tournament — which will consist of two stages including Group Play and the Knockout Rounds — starts Oct. 30 and will end with the title game (Dec. 11) at Hinkle Fieldhouse ...

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Jun 30 • 10:37 PM EDT • Sports • sports.yahoo.com
NYC Health + Hospitals/Metropolitan and MetroPlusHealth Support New Mother of Triplets

New York, NY – NYC Health + Hospitals/Metropolitan, in partnership with MetroPlusHealth, today shared the story of Doris A. Lucio Lucio, an immigrant

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Jun 30 • 2:06 PM EDT • Health • nychealthandhospitals.org
New business collective boosts Detroit Lakes community

Collaboration helps small businesses compete

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Jun 30 • 8:00 AM EDT • Business • grandforksherald.com
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Twin Cities Somali businesses face long, slow recovery after Operation Metro Surge

Customer traffic and spending remain down, and many Somali-owned shops have had to lay off workers and fallen behind on rent.

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Jun 30 • 7:00 AM EDT • Business • sahanjournal.com
CBS shares Lions' potential Terrion Arnold replacements

After his Monday release, CBS shared some potential Terrion Arnold replacements the Lions can consider.

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Jun 30 • 5:47 AM EDT • Sports • sports.yahoo.com
Steel boss mulls reopening of Dearborn Works blast furnace

Cleveland-Cliffs CEO Lourenco Goncalves said the company is closer to resuming idled production — if automotive demand increases.

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Jun 30 • 5:45 AM EDT • Business • crainsdetroit.com
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Cyclosporiasis cases on the rise in Monroe County, health officials say

An outbreak of Cyclosporiasis is spreading in Monroe County, health officials announced on Monday.

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Jun 29 • 8:39 PM EDT • Health • fox2detroit.com
Terrion Arnold released: Where Lions go from here after secondary suffers loss, plus potential replacements

The Lions cut ties with their former first-round pick after his arrest on kidnapping and armed robbery charges, leaving a void in Detroit's secondary.

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Jun 29 • 7:22 PM EDT • Sports • cbssports.com
Weston Port, three-star LB, commits to Michigan football

Three-star linebacker Weston Port committed to U-M in the class of 2027 on Monday, June 29.

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Jun 29 • 7:13 PM EDT • Sports • sports.yahoo.com
Salary cap ramifications of Terrion Arnold’s release

Breaking down the finances and salary cap ramifications Terrion Arnold’s release from the Detroit Lions.

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Jun 29 • 5:48 PM EDT • Sports • sports.yahoo.com
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Chris Brown and Usher Detroit tickets: How to get the best deals to July 2, 3, 5 shows
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Jun 29 • 2:53 PM EDT • Entertainment • cleveland.com
Copp inspires, connects with high-achieving athletes at 2025-26 Detroit High School Sports Awards

Last Wednesday, Red Wings forward served as special guest and participated in Q&A at MotorCity Casino Hotel

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Jun 29 • 1:07 PM EDT • Sports • nhl.com
DMC Sinai-Grace holds 2nd annual health fair with free screenings, food, entertainment

DMC Sinai-Grace Hospital is taking patient care beyond the hospital walls and into the heart of the Detroit community.

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Jun 29 • 8:56 AM EDT • Entertainment • clickondetroit.com
DMC Sinai-Grace holds 2nd annual health fair with free screenings, food, entertainment

DMC Sinai-Grace Hospital is taking patient care beyond the hospital walls and into the heart of the Detroit community.

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Jun 29 • 8:56 AM EDT • Health • clickondetroit.com
Housing, groceries, and medical needs: Detroit’s Health Hubs helping to get kids to school

Since their launch in 2023, DPSCD’s Health Hubs have helped thousands of families and contributed to improving attendance for many students, according to the district.

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Jun 29 • 6:00 AM EDT • Health • chalkbeat.org
WGU’s flexible, skills-first pathways are bridging Detroit’s talent gap

Discover how skills-first education is helping employers address workforce shortages across Southeast Michigan.

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Jun 29 • 5:00 AM EDT • Business • crainsdetroit.com
Framingham Baking Co. workers 'couldn't let it go.' What they did next

Two former Framingham Baking Company kitchen workers have started their own baking business.

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Jun 29 • 4:46 AM EDT • Business • metrowestdailynews.com
Colorado’s regulations should address policy challenges only as truly needed

As Colorado approaches its 150th birthday, we should remember its first 100 years were characterized by repeated boom-and-bust economic cycles. Dependence on mineral extraction and agricultural commodity prices was subject to the volatility of these markets. In 1972, as I arrived in Denver with Ma Bell, 40,000 metro households were waiting for dial tone since […]

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Jun 29 • 2:45 AM EDT • Politics • coloradopolitics.com
Detroit Tigers Release 3-Year MLB Player Before Yankees Series

On Monday night, the Detroit Tigers will open up a series with the New York Yankees in the Bronx.They are coming off a 7-5 loss to the Houston Astros on Sunday (at home).Detroit Tigers Release 3-Year MLB PlayerEarlier this week, news came out that the Tigers had released Konnor Pilkington from their organization (h/t MLB […] The post Detroit Tigers Release 3-Year MLB Player Before Yankees Series appeared first on HEAVY.

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Jun 29 • 2:05 AM EDT • Sports • sports.yahoo.com
Sans federal support, state election admins worry about interference
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Jun 28 • 11:44 PM EDT • Politics • detroitnews.com
Why Rock Ya-Sin Is Poised to Replace Terrion Arnold

No matter what happens in court, the Lions have a major problem to solve—and Rock Ya-Sin may be the biggest beneficiary.

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Jun 28 • 5:35 PM EDT • Sports • sports.yahoo.com
3 Michigan Hockey players selected during 2026 NHL Draft

Michigan Hockey maintained its pipeline to the pros with 3 Wolverines hearing their names called during the 2026 NHL Draft, including a first-rounder by the Detroit Red Wings:

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Jun 28 • 5:27 PM EDT • Sports • sports.yahoo.com
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Efzimfotase alfa demonstrated improvements in bone health in treatment-naïve pediatric patients with hypophosphatasia achieving median difference of 1.67 vs placebo in RGI-C Score at week 25 in MULBERRY Phase III trial

Positive results from the MULBERRY Phase III trial showed that efzimfotase alfa (ALXN1850), an investigational enzyme replacement therapy, demonstrated a statistically significant and clinically meaningful improvement in bone health in children (2 to

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Jun 28 • 3:45 PM EDT • Health • astrazeneca-us.com
Executive Summary: Slowing down, listening a part of Gehrig’s leadership

Editor’s note: The Fort Smith Metro Daily News Executive Summary series is focused on looking under the title, so to speak, of a business, government, and non-profit executive in the...

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Jun 28 • 1:33 PM EDT • Business • talkbusiness.net
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Employees of downtown businesses in metro Atlanta city will get special parking

Change is coming to downtown parking in Powder Springs.

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Jun 28 • 10:58 AM EDT • Business • wsbtv.com
These Michigan businesses are finding a silver lining with tariffs
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Jun 28 • 9:56 AM EDT • Business • detroitnews.com
Retro Recap: All The Classic Gaming News From The Past Week (June 28th 2026)

Sonic pinball! Retroid Pocket Nova! Star Fox 64!

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Jun 28 • 7:00 AM EDT • Technology • timeextension.com
Yzerman Explains Why Red Wings Left Traverse City

The post Yzerman Explains Why Red Wings Left Traverse City appeared first on Detroit Hockey Now. The Detroit Red Wings brought to a halt a nearly three-decade tradition this week. The club made the announcement that […] The post Yzerman Explains Why Red Wings Left Traverse City appeared first on Detroit Hockey Now.

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Jun 28 • 4:00 AM EDT • Sports • sports.yahoo.com
Could Ennis Rakestraw Save the Lions’ Secondary?

Terrion Arnold’s arrest has left a major hole in Detroit’s secondary. Could this finally be Ennis Rakestraw’s chance to prove he belongs?

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Jun 28 • 1:50 AM EDT • Sports • sports.yahoo.com
Q&A: Mike Rogers on the Iran deal, weaponization fund, bridge politics

As Democrats beat one another up in a primary, GOP's Mike Rogers says his second bid for Senate is "night and day" over where he stood two years ago

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Jun 28 • 12:01 AM EDT • Politics • detroitnews.com
Steve Yzerman on Red Wings' Dylan Larkin trade request

GM Steve Yzerman made his first public comments since Dylan Larkin's request to be traded by the Detroit Red Wings to a contender.

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Jun 27 • 5:06 PM EDT • Sports • sports.yahoo.com
GameThread: Detroit Tigers vs. Houston Astros, 6:40 p.m.

Detroit Tigers (35-46) vs. Houston Astros (40-44) Time/Place: 6:40 p.m., Comerica ParkSB Nation Site: The Crawfish BoxesMedia: Detroit SportsNet, MLB.TV, Tigers Radio NetworkPitching Matchup: LHP Framber Valdez (4-5, 3.91 ERA) vs. RHP Kai-Wei Teng (4-6, 4.03 ERA)

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Jun 27 • 1:00 PM EDT • Sports • sports.yahoo.com
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NHL Rumors: 3 Red Wings Who Could Be Traded Next

The Detroit Red Wings made a notable trade on Friday, as they traded top goalie prospect Sebastian Cossa to the Utah Mammoth in exchange for the 23rd overall pick of the NHL Entry Draft. The Red Wings then used that pick to select forward J.P. Hurlbert.Seeing Cossa get traded by the Red Wings is not […] The post NHL Rumors: 3 Red Wings Who Could Be Traded Next appeared first on HEAVY.

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Jun 27 • 7:28 AM EDT • Sports • sports.yahoo.com
Lions announce 2026 training camp fan schedule, times

Here's when fans can catch the Detroit Lions during 2026 training camp.

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Jun 27 • 6:45 AM EDT • Sports • sports.yahoo.com
Colonial Market owner closes south Minneapolis location due to sharp drop in business following Metro Surge

Colonial Market owner Daniel Hernandez has closed the chain’s south Minneapolis location, which he said never recovered after the store’s employees and customers were targeted during Operation Metro Surge.

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Jun 26 • 2:38 PM EDT • Business • sahanjournal.com
5 free agent cornerback options for the Detroit Lions

Five cornerback additions the Detroit Lions should consider after Terrion Arnold’s arrest.

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Jun 26 • 8:18 AM EDT • Sports • sports.yahoo.com
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Tigers host the Astros on home losing streak

The Detroit Tigers are looking to stop their three-game home slide with a victory against the Houston Astros

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Jun 26 • 4:09 AM EDT • Sports • foxsports.com
Elliot Cadeau appears set to return to Michigan basketball roster

For the third and presumably final time this offseason, Elliot Cadeau appears to have confirmed he will stay with Michigan basketball.

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Jun 25 • 10:56 PM EDT • Sports • sports.yahoo.com
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Asthma, maternal health, climate disasters: How Detroit’s health director is tackling city’s health disparities

Detroit health director discusses tackling childhood asthma, maternal health, climate disasters through Health in All Policies approach.

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Jun 25 • 7:00 PM EDT • Health • planetdetroit.org
Digital-Only 'Grand Theft Auto VI' Is a Car Crash for Physical Media

Not all progress is progress.

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Jun 25 • 6:29 PM EDT • Technology • hollywoodreporter.com
ESPN believes Detroit Lions have best weapons in NFL

ESPN’s Bill Barnwell believes the Detroit Lions have better offensive weapons than any other NFL team in 2026.

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Jun 25 • 6:20 PM EDT • Sports • sports.yahoo.com
Commodore Has Dropped The Price Of Its Retro Phone By $100 Ahead Of Preorders

A refreshing direction for a price change.

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Jun 25 • 5:34 PM EDT • Technology • engadget.com
Making Our Own Luck

We are cross-posting a piece that former NIH official Kris Willis wrote for Macroscience. Kris is now the President and Founder of the Woodley Park Institute, for which I’m a board member. Picking winners or hedging bets? Federal science agencies have long wrestled with the question of how to ensure their billions of dollars of grants and contracts result in maximum benefits for Americans. On the surface, it might seem that a goal-oriented, interventionist style of management would be the best policy: prioritize our most pressing problems and distribute funding accordingly.This top-down strategy creates a unique hazard, though: bad choices can send resources in the wrong direction, resulting in slow progress that impedes the delivery of tangible benefits to citizens. Moreover, if decision makers pursue an applied advance when the underlying scientific principles remain poorly understood, they risk costly failures and a loss of support for the research enterprise at large. Examples include Nixon’s 1971 War on Cancer, undertaken on the premise that a cure could be achieved in less than a decade, the drive to build an operational commercial fusion plant by the mid-1990s, and the National Plan to Address Alzheimer’s Disease, which failed to produce the effective treatments and prevention strategies promised by 2025. The contrasting laissez-faire approach is to hedge your bets. If the path to an advance is impossible to predict, then the wisest choice might be to distribute funding to as widely as possible. The main risk of this strategy is that spreading funding thinly may limit the resources available to the most promising research, resulting in the same negative outcomes as the interventionist approach: limited support for the most promising topics, slow progress, and delayed returns. In reality, at science agencies like the National Science Foundation and National Institutes of Health, program managers navigate between these two extremes, setting some funds aside to target high-priority areas and using the rest to cover the widest possible range of meritorious proposals. This middle path seems like the most rational way to proceed, but it still requires making choices. How much should be set aside for high priority topics? What should those topics be? How should we define merit? Expert opinion can provide a helpful guide, but leading experts can have remarkably different opinions about what matters and what should be prioritized. Moreover, experts and administrators alike can be risk averse, giving an edge to high-profile, well-established concepts. What’s really needed is a data-driven framework to help guide decision-making, one that doesn’t simply repackage prestige or incumbency. Recognizing breakthroughs years in advance Many breakthroughs fail to attract funding or recognition at the earliest stages of development. Katalin Karikó, for example, spent years struggling to win grants for work on mRNA that would eventually win her and Drew Weissman a Nobel Prize. Similar stories can be told about Jim Allison’s groundbreaking studies leading to the development of cancer immunotherapy, Stan Pruisner’s demonstration that prions can self-replicate without DNA, or Robin Warren and Barry Marshall’s proof that Helicobacter pylori, not stress, causes ulcers. Yet at some point, the scientific community recognizes and responds to transformative breakthroughs like these. How does that change happen? And what if science funders could identify the areas that are on the cusp of a breakthrough? Those questions led my collaborators and me to study how scientists responded to past breakthroughs. Based on patterns in that data, we developed a means of predicting future breakthroughs, using biomedicine as a proof of concept. It’s worth taking a moment to describe how our approach works. Briefly, our prediction process begins by grouping the 18 million or so peer-reviewed papers in PubMed, the authoritative database of biomedical research, into roughly 50,000 unique topics. A small subset of these topics are so widely acclaimed as breakthroughs that they have been recognized with a major prize like a Nobel or a Lasker Award. We theorized that studying the development of these outliers over time, especially before they gained acclaim, was the key to identifying future instances of them. After defining topics, we chose 21 representative breakthroughs and asked what they looked like before they won prestigious prizes. To answer that question, we re-ran our topic-mapping algorithm repeatedly, winding back the clock one year each time, stringing together the years to follow the progress of each field as it grew and advanced. We found that in each case, the years leading up to a discovery followed a pattern: a burst of papers on a new, rapidly evolving topic, many of which quickly became influential. These characteristics—the percent of papers that are new, the percentage of papers that are brought in from other topics, and the influence of each individual paper—can all be measured separately for any given topic. Together, they act as a predictive signal that is detectable an average of five years before a transformative discovery is made, and up to thirty years before the discovery receives a major prize. Scanning the current research landscape for topics that display this signal allows us to predict what work will likely produce a future breakthrough. Each year we analyzed includes four or five signals, a number that appears to have remained constant across a twenty year time frame. In their classic work on the sociology of science, Bruno Latour and Steve Woolgar established that the desire to participate in a major discovery is an important motivator for scientists as they consider whether they should take up (or abandon) a research problem. Although further work is needed, the simplest explanation for our results is that this behavior is widespread enough to detect at scale. A foundational advance, or something like it, draws the attention of scientists and causes them to change the direction of their research. They vote with their feet, staking their own reputation and careers by publishing on and citing the new idea. That upswell of interest is the foundation of our breakthrough signal. What kind of research does our model identify as a breakthrough? After building a model based on the patterns in our 21 preselected breakthroughs, we tested it by identifying all early signals of discovery from 1994 through 1997. Of the 18 signals we found in that time period, 17 can be traced forward in time to a breakthrough. Examples include super-resolution fluorescence microscopy (see the image above), the directed evolution of proteins and enzymes (Chemistry Nobel, 2018), and sequencing the human genome (National Medal of Science, 2008). The discovery of the role of leptin signaling in obesity is a particularly interesting case study. Around 1950, scientists noticed the existence of a type of lab mouse that suffered from a unique inherited form of obesity. When given the freedom to choose their own diet, these mice ate more than normal and preferred food that was high in fat. Researchers had few clues as to why the animals overate; early experiments pointed to the existence of a soluble ob factor found circulating in the bloodstream that regulated appetite, but its identity was unknown. In 1994, Jeffrey Friedman and colleagues identified and sequenced the ob gene, noting that the protein it encoded appeared to fit the profile of a circulating factor. A year later, a trio of high-profile publications demonstrated that ob was a hormone that regulated body weight and fat deposition by regulating appetite. One of these was co-authored by Friedman, who christened it leptin from the ancient Greek word for thin. Using our model, the data from 1996 make it clear this advance would become a breakthrough. Scientists had flocked to study the biology of the new hormone, generating the flurry of new papers and citations required to produce a signal. One of these demonstrated that serum leptin concentrations reflected the amount of adipose tissue in the human body, providing clinical validation of the earlier mouse studies. Before the identification of leptin, scientists were unable to point to a specific molecule that controlled appetite and adiposity, so that it was impossible to rule out non-physiological causes of obesity; its characterization fundamentally changed our concept of weight gain. In 2010, Friedman and fellow pioneer Douglas Coleman were awarded a Lasker for the discovery. Our work also identifies breakthroughs in clinical practice and behavioral and social sciences, even though these areas are less likely to draw the attention of major prize committees. One example that falls into this category is the introduction of endovascular aneurysm repair, a minimally invasive surgical procedure for the treatment of abdominal aortic aneurysm, a leading cause of death among Americans over the age of 65. Relative to the previous standard of care, it reduces in-hospital mortality by almost four-fold. In 2017, Timothy Chuter received the American College of Surgeons’ prestigious Jacobsen Innovation award for his multiple refinements to the technique. Another under-recognized breakthrough identified by our model is the development of standardized survey instruments to assess the quality of life for HIV+ patients. The antiretroviral cocktails introduced in the mid-1990s reduced AIDS mortality, but treatment came with serious side effects. The new evaluations showed that patients whose disease progressed had worse physical functioning than Americans with other chronic diseases, while those who were asymptomatic maintained a health-related quality of life on par with the overall US population. This evidence made it possible for patients and activists to argue that even in the absence of a total cure, and in spite of the side effects, alleviation of symptoms was a worthwhile priority for clinicians. My colleagues and I have failed to identify any significant recognition for the physicians and health policy experts who pioneered this advance, although in 2016, researchers called for the World Health Organization to set targets for good health-related quality of life as part of its framework to end the AIDS pandemic. From forecasting to funding How should science funders use our predictions? Any serious discussion of what we should do with this new capability needs to begin with an understanding of its limitations. We can’t (and shouldn’t) invest all of our resources in the small number of topics predicted to produce breakthroughs. Innovative new fields are born from existing ones; they rarely arise de novo. If funders don’t maintain a diverse portfolio, the breakthroughs of tomorrow will have no antecedents. Think of this as eating the seed corn, or killing the goose that lays the golden egg. There are also multiple goals of funding beyond basic scientific discovery, including translating discoveries into clinical practice, developing new technologies, supporting economic development, and training new scientists. The investments needed to accomplish these goals are likely different from those required to support emerging breakthroughs. Finally, we must be aware that we may not capture every instance of a breakthrough. The concept is fuzzy, and not every significant discovery is recognized with a major award. Further, breakthroughs are rare, meaning that our dataset is, by necessity, small. This makes formal estimates of accuracy challenging. Although our overall success rate appears to be high, any one signal may turn out to be a false positive. We found one apparent example: the development of the third generation COX-2 inhibitors, Vioxx and Celebrex, which were much celebrated in the early 2000s as effective but non-addictive pain relievers, meets all the algorithmic criteria of a breakthrough. Five years after it received FDA approval, researchers demonstrated that Vioxx was associated with serious cardiovascular complications, and the manufacturer voluntarily pulled the drug from the market. Celebrex remains available, although like other NSAIDs, it carries an FDA warning for increased cardiovascular risk. Decision makers who were overly focused on the breakthrough potential of this research might have wasted substantial resources nurturing an area that ultimately proved to be a failure—but so would those who relied on expert opinion at the time. That said, the potential benefits of funding the next mRNA vaccine or cancer immunotherapy years earlier than we might have are large. When we can’t assume the outcome of an action, it’s worth conducting an experiment. Can targeted support for areas that are poised to produce a breakthrough increase the return on scientific investment without cannibalizing future advances? With the necessary administrative infrastructure in place, conducting this experiment would be straightforward. First, identify all the breakthrough signals between 2018 and 2023, select half at random, and commit to a decade of investment. For biomedicine, a six year window should yield about 30 topics with the potential to produce a breakthrough. Providing strong support to half of these might be accomplished for $300 million a year. That’s roughly half of the recent annual budget of the NIH Common Fund or around 20% of the fiscal year 2025 budget for ARPA-H. After five years, then again at ten, compare to see which group — the one that was actively managed, or the control — produced more breakthroughs, and on what timescale. Although we used biomedicine as an example, the same experiment could just as well be run for physics, materials science, or any other discipline. Any attempt to undertake such an experiment should keep three points top of mind. First, we can predict the topic of future breakthroughs, but the people and vision for how to move the work forward are still important. In practice, this means success requires active program managers with the expertise to develop the science and the authority to do so, including by recruiting investigators. Second, we would be wise to learn from the failures of past attempts to fund transformative research. High among these are funding modestly repackaged work, confusing the genuinely novel with the merely unfamiliar, and relying too much on incumbent investigators. All of these risks can be mitigated by thoroughly and intelligently integrating high quality data into portfolio management. Finally, we need to have patience. Even with strong funding support, producing a breakthrough takes time. If supporting breakthroughs is the best way to nurture the birth of new fields, we also need to accurately describe and properly manage the other two stages, so that we invest wisely throughout the productive lifetime of ideas and divest once they reach the point of diminishing returns. We would benefit from more study of all of these phases, especially the transition from one to another. More research could answer questions like: When does a breakthrough become an established field? How do the availability of funding, the size and characteristics of the available workforce, and the accumulation of evidence that disagrees with prevailing models affect a field’s decline? Exactly how do old ideas give birth to new ones, and can we speed up the process? The more we understand about the dynamics of scientific progress, the better we can maximize the odds that our curiosity leads to results. I’d call that finding a way to make our own luck.

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Jun 25 • 4:48 PM EDT • Science • goodscience.substack.com
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How many professional sports teams are in Austin?

With all the buzz around bringing more professional sports teams to the metro area, it’s worth considering how many are already here.

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Jun 25 • 4:44 PM EDT • Sports • kxan.com
Game On Retro owner plans entertainment empire expansion, Coram movie theater transformation

Plans include opening a new arcade, store and transforming a shuttered movie theater in Coram.

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Jun 25 • 12:32 PM EDT • Entertainment • newsday.com
Gilbert-backed Cosm gets $100M Sony investment as immersive theater operator expands to Detroit

A Cosm location in downtown Detroit is expected to open in September as part of Dan Gilbert’s Bedrock LLC real estate firm’s Development at Cadillac Square project.

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Jun 25 • 9:26 AM EDT • Entertainment • crainsdetroit.com
Chick-fil-A gets into the home repair and services business

The popular chicken chain has brought its hospitality prowess to a new industry in metro Atlanta — home services.

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Jun 25 • 6:00 AM EDT • Business • ajc.com
ESPN proposes final offseason moves for Detroit Lions

ESPN proposed final offseason moves for the Detroit Lions.

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Jun 25 • 5:47 AM EDT • Sports • sports.yahoo.com
De la Espriella pledges to restore Colombia’s relations with Israel

The far-right president-elect has pledged to rebuild ties with Israel and the US following tensions under Gustavo Petro.

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Jun 24 • 3:56 PM EDT • Politics • aljazeera.com
Pistons reportedly wanted Lakers star Austin Reaves, but missed out

A potential Detroit Pistons target in free agency is officially off of the board, as Austin Reaves has re-signed with the Lakers.

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Jun 24 • 2:17 PM EDT • Sports • sports.yahoo.com
Perks of the job: Save on entertainment and essentials with BenefitHub

State of Colorado employees have access to a wide-ranging corporate discount marketplace, and those eligible for benefits at Metropolitan State University of Denver can take advantage of them with their University email. The State of Colorado BenefitHub offers deals on thousands of products, ranging from vacation and event tickets to insurance and other essential services. […]

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Jun 24 • 1:46 PM EDT • Entertainment • early-bird.msudenver.edu
Optimum Business, Woodbridge Metro Chamber of Commerce announce small business program

Optimum Business and the Woodbridge Metro Chamber of Commerce announced the founding of the “Lifting up Small Businesses in Woodbridge, New Jersey.”

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Jun 24 • 10:06 AM EDT • Business • roi-nj.com
Detroit officials share health impact report
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Jun 24 • 8:39 AM EDT • Health • cbsnews.com
Deep dive High-Signal Publisher
😐 Neutral (12%)
angry
40%
wow
40%
ahah
20%
A retro outdoor food park and entertainment venue is coming to Seminole Heights this fall

A slice of Old Florida could be coming to Seminole Heights this fall. Developers last week announced plans for Nebraska Roadside, an open-air food park and

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Jun 24 • 7:52 AM EDT • Entertainment • thatssotampa.com
New York Yankees @ Detroit Tigers: Carlos Rodón vs. Casey Mize

Rodón looks to end this brief three-game skid and set up a Wednesday rubber game.

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Jun 23 • 6:17 PM EDT • Sports • sports.yahoo.com
'The Adventures of Juan Planchard': A political thriller that reads like a blockbuster

NPR's Scott Detrow speaks with author and filmmaker Jonathan Jakubowicz about his book The Adventures of Juan Planchard, now translated into English.

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Jun 23 • 6:16 PM EDT • Politics • npr.org
High-Signal Publisher
Why Trump (and other politicians) are going to sporting events

NPR's Scott Detrow talks with University of Richmond political scientist Dan Palazzolo about the politics of officials affiliating with sports.

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Jun 23 • 5:45 PM EDT • Politics • npr.org
High-Signal Publisher
😐 Neutral (6%)
Why Trump (and other politicians) are going to sporting events

NPR's Scott Detrow talks with University of Richmond political scientist Dan Palazzolo about the politics of officials affiliating with sports.

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Jun 23 • 5:45 PM EDT • Sports • npr.org
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😐 Neutral (6%)
Detroit releases report with plans to tackle community health issues

Mayor Mary Sheffield and the Detroit Health Department released a comprehensive roadmap to tackle top health concerns identified by residents by 2028.

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Jun 23 • 1:34 PM EDT • Health • freep.com
Red Wings Talking Larkin Trade With Stars?

The post Red Wings Talking Larkin Trade With Stars? appeared first on Detroit Hockey Now. First it was the Minnesota Wild as the favorite to trade for Detroit Red Wings captain Dylan Larkin. Then it […] The post Red Wings Talking Larkin Trade With Stars? appeared first on Detroit Hockey Now.

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Jun 23 • 9:44 AM EDT • Sports • sports.yahoo.com
GameThread: Detroit Tigers vs. New York Yankees, 6:10 p.m.

Detroit Tigers (33-44) vs. New York Yankees (46-30) Time/Place: 6:10 p.m., Comerica ParkSB Nation Site: Pinstripe AlleyMedia: Detroit SportsNet, MLB.TV, Tigers Radio NetworkPitching Matchup: LHP Framber Valdez (3-5, 4.09 ERA) vs. RHP Gerrit Cole (2-1, 2.57 ERA) Lineups YANKEES TIGERS Amed Rosario – 3B Kevin McGonigle – 3B Ben Rice – DH Dillon Dingler – C Paul Goldschmidt – 1B Kerry Carpenter […]

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Jun 22 • 6:00 PM EDT • Sports • sports.yahoo.com
Hackensack Meridian plans Hunterdon Health acquisition

Hackensack Meridian Health and Hunterdon Health signed a letter of intent to pursue a merger. The acquisition aims to expand healthcare access and innovation in New Jersey.

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Jun 22 • 1:31 PM EDT • Health • njbiz.com
Wallside Windows co-owner gives another $20M to Corewell Health

The health system said it will name its new 89,000-square-foot Royal Oak care center after Stuart Blanck's parents.

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Jun 22 • 1:27 PM EDT • Health • detroitnews.com
Detroit's women's sports bar, Bar IX, launches crowdfunding campaign -- How to get involved

As Detroit's women's sports bar continues to draw crowds to pop-up watch parties, the team behind Bar IX is now centering its efforts on finding a permanent place to call home.

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Jun 22 • 10:10 AM EDT • Sports • fox2detroit.com
1 in 3 Americans use chatbots for health advice. These 6 patients explain why.

Chatbots fueled by AI bear disclaimers saying they cannot dispense medical advice or diagnose conditions, but they still field millions of queries.

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Jun 22 • 9:04 AM EDT • Health • detroitnews.com
PWHL adds Kilmer Sports Ventures, Ilitch Companies as first outside investors

Just one month after completing its third season, the Professional Women’s Hockey League has added its first outside investment, the league announced on Monday morning. Kilmer Sports Ventures, which is led by Toronto businessman Larry Tanenbaum, and Ilitch Companies, the parent company of the NHL’s Detroit Red Wings and MLB’s Tigers, have joined the league as partners. Since its inception, the league has operated under a single-entity ownership model, meaning Mark Walter — the billionaire owner

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Jun 22 • 9:01 AM EDT • Sports • sports.yahoo.com
PWHL adds Kilmer Sports Ventures, Ilitch Companies as first outside investors

Kilmer Sports Ventures is led by Larry Tanenbaum, who brought the WNBA to Toronto, while the Illitch family owns the Detroit Red Wings.

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Jun 22 • 8:48 AM EDT • Sports • nytimes.com
😐 Neutral (13%)
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100%
PWHL announces Ilitch Companies will be among first outside investors

The Ilitch family will be one of the first two outside investors into the Professional Women's Hockey League (PWHL), the league announced Monday morning.

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Jun 22 • 8:28 AM EDT • Sports • wxyz.com
PWHL adds Ilitch Companies, Kilmer Sports Ventures as investors

The PWHL announced Monday it has added Detroit-based Ilitch Companies and Toronto-based Kilmer Sports Ventures as its first two investors.

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Jun 22 • 8:08 AM EDT • Sports • espn.com
“Criminal Approach to Politics”: Trump Ally Abelardo de la Espriella Wins Colombian Presidency

Right-wing Trump ally Abelardo de la Espriella has clinched a narrow victory in Sunday’s runoff presidential election in Colombia, defeating leftist Senator Iván Cepeda, an ally of current President Gustavo Petro. De la Espriella ran a fearmongering, “tough-on-crime” campaign, promising to build mega-prisons inspired by El Salvador’s authoritarian President Nayib Bukele, to bomb “narcoterrorist camps” and to abandon Petro’s peace efforts. His reported victory is also a win for U.S. President Donald Trump, whose administration is waging an intensifying “war on drugs” across Latin America, targeting left-wing leaders like Petro with false allegations and threats of military intervention. “De la Espriella clearly represents a criminal approach to politics: lying, propaganda, coordination and collusion with criminal narcotrafficking, restriction of rights, and money laundering,” says longtime Colombian activist Manuel Rozental. With his victory, says Rozental, “We expect to have military operations and a U.S. intervention within the country. We expect to have human rights abuses. We expect to have militarization. And it’s all for the extraction of resources and the link of drug trafficking to the U.S. government, U.S. interests and global mafia.”

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Jun 22 • 8:00 AM EDT • Politics • democracynow.org
Kansas City small businesses say World Cup is hurting sales. There's no bump like the city promised

Kansas City has welcomed thousands of visitors as the metro enters its second week of the World Cup. But as international crowds come in, many local shop owners feel they're taking a backseat. Some small businesses say the economic boost is not evenly distributed.

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Jun 22 • 6:28 AM EDT • Business • kcur.org
Utica ballpark to host its first music festival

The professional baseball league operator is bringing another entertainment option and revenue stream to the ballpark.

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Jun 22 • 6:00 AM EDT • Entertainment • crainsdetroit.com
Opinion: Michigan has policy options to help curb online betting addiction

More than five years into legal sports betting, it is time for a fresh look at how Michigan regulates the industry and addresses the ripple effects on public health.

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Jun 22 • 5:45 AM EDT • Business • crainsdetroit.com
Opinion: Michigan’s goal should be to protect its online gaming market

As Michigan enters the next chapter of its legal sports betting and online gaming industry, we should pursue policies that strengthen the regulated market

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Jun 22 • 5:45 AM EDT • Sports • crainsdetroit.com
Opinion: We should restrict gambling marketing to protect youth

If we are going to permit online gaming and sports betting in our state, this is the least we can do to protect Michigan youth from misleading, coercive ads.

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Jun 22 • 5:45 AM EDT • Sports • crainsdetroit.com
Opinion: We should restrict gambling marketing to protect youth

If we are going to permit online gaming and sports betting in our state, this is the least we can do to protect Michigan youth from misleading, coercive ads.

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Jun 22 • 5:45 AM EDT • Business • crainsdetroit.com
Jet-engine manufacturer plots expansion in Pontiac on site of former movie studio

Williams International is seeking a 15-year extension of its Renaissance Zone tax break to support an expansion.

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Jun 22 • 5:45 AM EDT • Business • crainsdetroit.com
😐 Neutral (8%)
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67%
ahah
33%
Prediction markets push gambling to new level, causing concern

The state is waging a legal fight to preserve oversight and tax revenue amid competition from the increasingly popular platforms, which are regulated by the federal government.

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Jun 22 • 5:44 AM EDT • Business • crainsdetroit.com
Detroit Pistons salary cap space heading into 2026 free agency

The Detroit Pistons have financial flexibility to sign key players during the NBA's free agency period.

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Jun 22 • 5:03 AM EDT • Sports • sports.yahoo.com
Yashica's New Keychain Camera Has A Flip Screen And Costs Under $30

If you're enjoying other retro cameras that are currently on the market, Yashica has a new micro version that is just small enough to fit on a key ring.

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Jun 21 • 9:17 PM EDT • Technology • bgr.com
Will Isaiah Pacheco Be the Lions’ Biggest Free-Agent Steal?

Detroit took a chance on Isaiah Pacheco. If he returns to his 2023 form, the Lions may have landed the steal of free agency.

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Jun 21 • 8:51 PM EDT • Sports • sports.yahoo.com