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HVEN Inbound: Dream 2 Science

Deep house duo Dream 2 Science play their first live show in Japan at HVEN in Nakameguro, Tokyo, on November 6.

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Oct 26 • 1:59 AM EDT • Science • metropolisjapan.com
Chiefs Announce Historic Travis Kelce News During Seahawks Game

Kansas City Chiefs tight end Travis Kelce can’t stop making NFL history.With his third reception in the fourth quarter against the Seattle Seahawks on Sunday night, Kelce has passed Hall of Famer Tony Gonzalez for the most receiving yards by a tight end ever, including the postseason, with 13,342.Kansas City Chiefs’ Travis Kelce is Most […] The post Chiefs Announce Historic Travis Kelce News During Seahawks Game appeared first on HEAVY.

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Oct 26 • 1:46 AM EDT • Sports • sports.yahoo.com
Students and artificial intelligence industry leaders connect at inaugural Michigan AI Business Conference

More than 250 students, professors and industry leaders gathered Friday for the first Michigan Artificial Intelligence Business Conference at the Ross School of Business.

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Oct 26 • 1:43 AM EDT • Business • michigandaily.com
Mike Brown Drops Blunt Quote After Knicks Lose to Magic

New York Knicks head coach Mike Brown dropped a blunt quote after the Knicks lost to the Orlando Magic 111-102 on Sunday night.The start to the new NBA season has not gone well for New York, which is 0-3 to begin the season. Considering this team just won the NBA Championship back in June, it’s […] The post Mike Brown Drops Blunt Quote After Knicks Lose to Magic appeared first on HEAVY.

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Oct 26 • 1:39 AM EDT • Sports • sports.yahoo.com
Will Apple's overhauled MacBook Pro finally offer 5G cellular support?

This week, Apple will be overhauling the MacBook Pro for the first time since 2021. OLED, touch support, and a...

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Oct 26 • 1:16 AM EDT • Technology • 9to5mac.com
14-year-old Ngozi Wright makes feature film début

At just 14 years old, Ngozi Muzik Wright adds another milestone to an impressive performing arts journey that began when she was barely old enough to speak. The gifted young Jamaican, whose commanding dub poetry performances have captivated audiences at home and throughout the diaspora, has stepped on to the big screen in her first full-length feature film, From A Yardie To A Yankee.

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Oct 26 • 1:06 AM EDT • Entertainment • jamaica-gleaner.com
Lorna Goodison wins 2026 Derek Walcott Prize for Poetry

Celebrated Jamaican poet Lorna Goodison has added another prestigious international honour to an already distinguished literary career, winning the 2026 Derek Walcott Prize for Poetry for her ground-breaking new translation of the 14th-century classic, Dante’s Inferno. Goodison, Jamaica’s first female Poet Laureate, serving from 2017 to 2020, receives the US$2,000 prize for a work that boldly transports Dante’s epic journey into a Caribbean landscape, drawing deeply on Jamaican language, culture, history and identity.

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Oct 26 • 1:06 AM EDT • Entertainment • jamaica-gleaner.com
‘Resident Evil’ film resurrects horror game franchise

The first “Resident Evil” game came out in 1996, and since then, the franchise has been working to bring zombies, creatures and deadly outbreaks to life. For the newest piece,

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Oct 26 • 1:00 AM EDT • Entertainment • valpotorch.com
‘End game’: Taylor Swift and Travis Kelce mocked by opponent

The Seattle Seahawks handed the Kansas City Chiefs their first loss of the season on Sunday night, and they made sure to rub it in afterward by trolling newlyweds Travis Kelce and Taylor Swift. After their 20-3 win on Sunday Night Football, the Seahawks posted a Swift-themed troll on social media, sharing a friendship bracelet…

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Oct 26 • 12:40 AM EDT • Sports • sports.yahoo.com
☹️ Negative (-5%)
sad
100%
Frustrated Broncos RB Refuses Interviews Following Cardinals Win

The Denver Broncos' veteran running back stormed out of their locker room following Week 7's win over the Arizona Cardinals. The post Frustrated Broncos RB Refuses Interviews Following Cardinals Win appeared first on HEAVY.

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Oct 26 • 12:22 AM EDT • Sports • sports.yahoo.com
How Lula beat Bolsonaro, broke records and halted the right-wing wave aligning Latin America with Trump in 20 days

Luiz Inácio Lula da Silva made history on Sunday, setting a record for Brazil and the rest of Latin America by becoming the first president to win a fourth term – and he did so days before turning 81, an age when many other leaders decide to leave politics behind.

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Oct 26 • 12:18 AM EDT • Politics • cnn.com
Raptors’ Kawhi Leonard to undergo testing after concerning injury update

Kawhi Leonard was missing in action on Sunday, as the Toronto Raptors lost to the Minnesota Timberwolves , 117-94, at Target Center. The Raptors fell to 2-1, while the Timberwolves improved to 3-0. Leonard was added to the injury report just an hour before tip-off. Toronto announced that the veteran forward was dealing with swelling in his left […] The post Raptors’ Kawhi Leonard to undergo testing after concerning injury update appeared first on ClutchPoints.

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Oct 26 • 12:02 AM EDT • Sports • sports.yahoo.com
Norman Silverman to Open First Flagship Store in Beverly Hills

Los Angeles diamond jeweler Norman Silverman is opening its first flagship store at The Maybourne Beverly Hills in December.

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Oct 26 • 12:01 AM EDT • Business • wwd.com
Dana White Outlines How Movsar Evloev Gets Another Title Shot

UFC president Dana White outlined how featherweight fighter Movsar Evloev could get another title shot at 145 lbs.Evloev was 20-0 in MMA and 10-0 in the UFC heading into UFC 333, but he suffered a brutal second-round knockout loss against UFC featherweight champion Alexander Volkanovski in a failed bid to become the promotion’s new 145 […] The post Dana White Outlines How Movsar Evloev Gets Another Title Shot appeared first on HEAVY.

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Oct 25 • 11:43 PM EDT • Sports • sports.yahoo.com
Daniel Cormier Says Alexander Volkov Should Get UFC Title Shot

UFC commentator Daniel Cormier says that Alexander Volkov deserves to be next in line to fight for the UFC heavyweight title. Volkov — who turned heads this week with a viral clip of him asking UFC president Dana White what he has to do to get a title shot — defeated Rizvan Kuniev at UFC […] The post Daniel Cormier Says Alexander Volkov Should Get UFC Title Shot appeared first on HEAVY.

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Oct 25 • 11:30 PM EDT • Sports • sports.yahoo.com
76ers veteran briefly raises alarm with injury scare vs. Pistons

The injury hits kept coming around the NBA on Sunday evening , but the Philadelphia 76ers seemingly avoided catastrophe with veteran guard Kentavious Caldwell-Pope. The veteran guard exited the game briefly , as per Adam Aaronson of The Philly Voice, with an apparent injury. While was initially tended to by team staff and accompanied back to the […] The post 76ers veteran briefly raises alarm with injury scare vs. Pistons appeared first on ClutchPoints.

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Oct 25 • 10:58 PM EDT • Sports • sports.yahoo.com
Travis Kelce’s Physical Appearance Turns Heads Before Seahawks Game

Kansas City Chiefs star Travis Kelce made waves with his appearance in Seattle before Sunday's game against the Seahawks. The post Travis Kelce’s Physical Appearance Turns Heads Before Seahawks Game appeared first on HEAVY.

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Oct 25 • 10:31 PM EDT • Sports • sports.yahoo.com
Observations after shorthanded Sixers fall to 1st loss of season

The shorthanded Sixers fell to their first loss of the season on Sunday night.

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Oct 25 • 10:15 PM EDT • Sports • nbcsportsphiladelphia.com
World-First Cancer Vaccine Cuts Melanoma Recurrence or Death Risk by 42% in Landmark Trial

"This has not been achieved before in the history of cancer drug development."

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Oct 25 • 10:00 PM EDT • Science • sciencealert.com
TWICE's Nayeon to make solo comeback with 'NA-sty' on Nov. 20

Na-yeon of K-pop girl group TWICE will release her new solo project, “NA-sty,” on Nov. 20, marking her first solo comeback in about two years and f...

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Oct 25 • 9:33 PM EDT • Entertainment • koreatimes.co.kr
Deep dive
😐 Neutral (10%)
wow
78%
ahah
22%
Deshaun Watson does just enough to guide Browns past Titans

Deshaun Watson threw for over 300 yards for the first time since the 2020 season in Week 7 against the Titans.

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Oct 25 • 9:29 PM EDT • Sports • sports.yahoo.com
☹️ Negative (-13%)
wow
100%
Celtics’ Joe Mazzulla Addresses Growing Tatum-Brown Tension

For years, Boston Celtics fans have wondered whether Jayson Tatum and Jaylen Brown were friends off the basketball court. Following Brown’s recent comments to the media, it’s become clear that even if they were, that isn’t the case anymore.On Sunday, October 25, Celtics’ head coach Joe Mazzulla was asked about Brown’s recent comments regarding Tatum […] The post Celtics’ Joe Mazzulla Addresses Growing Tatum-Brown Tension appeared first on HEAVY.

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Oct 25 • 9:28 PM EDT • Sports • sports.yahoo.com
Georgia lands son of music star in notable recruitment win

Georgia football secured a notable win during its bye week Sunday. And in the process, coach Kirby Smart and company win over fans of country star Luke Bryan. That’s because his son Bo Bryan is joining the 2027 recruiting class. The three-star quarterback chose the Bulldogs officially, becoming the newest College Football Recruiting win for […] The post Georgia lands son of music star in notable recruitment win appeared first on ClutchPoints.

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Oct 25 • 9:26 PM EDT • Sports • sports.yahoo.com
🙂 Positive (65%)
love
50%
wow
50%
Luka Doncic 50-Bomb Keeps Lakers’ Perfect Start Intact

Los Angeles Lakers guard Luka Doncic recorded a 52-point double-double in the Lakers' 132-123 win over the Utah Jazz on Sunday. The post Luka Doncic 50-Bomb Keeps Lakers’ Perfect Start Intact appeared first on LA Sports Report.

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Oct 25 • 9:16 PM EDT • Sports • sports.yahoo.com
🙂 Positive (100%)
Lions QB Jared Goff Ties NFL History Against Rival Packers

The Detroit Lions are back in action on Sunday afternoon at Ford Field against the divisional rival Green Bay Packers in a clash that will carry heavy implications for the NFC North standings. And thanks to yet another strong start from quarterback Jared Goff, he’s not only put his club in a position to pick […] The post Lions QB Jared Goff Ties NFL History Against Rival Packers appeared first on HEAVY.

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Oct 25 • 8:33 PM EDT • Sports • sports.yahoo.com
Rams Return to Winning Ways With Statement Win Over Raiders

The Los Angeles Rams beat the Las Vegas Raiders, 35-21, on Sunday, winning a game for the first time since Week 4. The post Rams Return to Winning Ways With Statement Win Over Raiders appeared first on LA Sports Report.

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Oct 25 • 8:28 PM EDT • Sports • sports.yahoo.com
Four Positives From Frustrating Start To New Orleans Pelicans Season

These are some of the biggest positives to take away from the first few games of the New Orleans Pelicans' season.

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Oct 25 • 8:20 PM EDT • Sports • sports.yahoo.com
Wizards at Hornets Preview: Washington heads south to Charlotte

Wizards head to Charlotte for their first matchup against the Charlotte Hornets this season.

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Oct 25 • 8:12 PM EDT • Sports • sports.yahoo.com
Peyton Manning’s Role in Colts GM Search Clarified After Chris Ballard Firing

Peyton Manning is one of the greatest players, if not the greatest, to ever play for the Indianapolis Colts. The former quarterback is one of the most decorated players in American football history. He has won the Super Bowl two times, and is a five-time NFL Most Valuable Player. The Colts have not found the […] The post Peyton Manning’s Role in Colts GM Search Clarified After Chris Ballard Firing appeared first on Gridiron Heroics.

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Oct 25 • 8:08 PM EDT • Sports • sports.yahoo.com
Supercomputer reveals first two billion years of ‘cosmic web’

The Center for Astrophysics’s simulation offers the most detailed look yet at the infancy of the universe after the Big Bang

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Oct 25 • 8:01 PM EDT • Science • thetimes.com
6 stellar images of the early universe

The most detailed simulation of our universe’s first 2 billion years to date.

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Oct 25 • 8:01 PM EDT • Science • popsci.com
Deep dive
😐 Neutral (16%)
wow
67%
ahah
33%
Tiny magnetic vortices could help computers work more like your brain

Scientists have filmed tiny magnetic vortices called skyrmions melting out of an organized lattice for the first time, revealing new ways to manipulate these unusual structures. The breakthrough could help make brain-like computers a reality, potentially enabling dramatically smaller and more energy-efficient technology.

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Oct 25 • 8:00 PM EDT • Science • sciencedaily.com
Columbiana County Health District approve first reading of food service fees

LISBON — The proposed food service fees for next year through the Columbiana County Health District appear to be staying the same or decreasing from this year’s fees, with two more readings required for passage. The county health district board held first reading on the proposed fees on Wednesday, along with first reading on environmental […]

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Oct 25 • 8:00 PM EDT • Health • salemnews.net
First round of 2026 high school football playoff matchups announced

Several area schools will play in the first round of the 2026 high school football playoffs this week.

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Oct 25 • 7:49 PM EDT • Sports • sports.yahoo.com
"Tomb Raider: Legacy of Atlantis" 30th Anniversary Trailer

A new trailer is out for “Tomb Raider: Legacy of Atlantis,” the reimagining of the original 1996 first “Tomb Raider” game. Created in Unreal Engine 5, it offers fresh visuals, skill trees, and an expanded Atlantis story that will tie in the various eras of Lara Croft together. As Lara, harness your wits and athleticism […]

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Oct 25 • 7:48 PM EDT • Technology • darkhorizons.com
LeBron James Fires Off Message After Browns’ Latest Win

LeBron James fired off a message after the Cleveland Browns’ latest escape agains the Tennessee Titans. The post LeBron James Fires Off Message After Browns’ Latest Win appeared first on HEAVY.

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Oct 25 • 7:35 PM EDT • Sports • sports.yahoo.com
Elon Musk’s Grok Imagine Releases First Odyssey Episode With Wonder Studios

8 sources compared: Other (4), Western Mainstream (3), Latin American (1). Elon Musk’s Grok Imagine released the first episode of its AI-generated series “The Odyssey,” posting a seven-minute vid...

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Oct 25 • 7:23 PM EDT • Entertainment • newscord.org
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😐 Neutral (16%)
ahah
100%
Chiefs vs. Seahawks live updates, inactives, where to watch: Kenneth Walker III faces Seattle for first time since Super Bowl MVP run
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Oct 25 • 7:01 PM EDT • Sports • sports.yahoo.com
6 stats from Barcelona 1-2 Real Madrid

A first away Clásico win in three years

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Oct 25 • 7:00 PM EDT • Sports • sports.yahoo.com
😐 Neutral (16%)
What’s going on with AJ Dybantsa’s ankle injury?

The Washington Wizards have started off playing well this season, and they’ve done so without the No. 1 overall pick. AJ Dybantsa hasn’t made his NBA debut yet as he deals with an ankle injury, and it looks like he’ll have to keep waiting after the latest update on his status, according to Brett Siegel of ClutchPoints. “AJ Dybantsa will remain […] The post What’s going on with AJ Dybantsa’s ankle injury? appeared first on ClutchPoints.

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Oct 25 • 6:53 PM EDT • Sports • sports.yahoo.com
Early voting underway in Michigan

Early voting began Saturday, Oct. 24 in Michigan. County officials say the first day of early voting went well and more than half of mail-in ballots have already been returned.

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Oct 25 • 6:51 PM EDT • Politics • abc12.com
Race Results: 2026 NASCAR Cup Series YellaWood 500 at Talladega

Kyle Larson took a thrilling win in a wild last-lap rally that led to a photo-finish with William Byron, his Hendrick Motorsports teammate. Larson, who was eighth heading down the backstretch of the final lap, had everything go his way ahead of him, as he sliced and diced his way back to the front. Ricky […] The post Race Results: 2026 NASCAR Cup Series YellaWood 500 at Talladega appeared first on TobyChristie.com.

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Oct 25 • 6:46 PM EDT • Sports • sports.yahoo.com
Vikings’ Aaron Jones Exits Colts Contest With Scary-Looking Injury

The Minnesota Vikings saw running back Aaron Jones Sr. go down with a leg injury late in their Week 7 game against the Indianapolis Colts. The post Vikings’ Aaron Jones Exits Colts Contest With Scary-Looking Injury appeared first on HEAVY.

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Oct 25 • 6:40 PM EDT • Sports • sports.yahoo.com
49ers' First Loss Makes It Clear: Their Toughest Opponent Is Their Health

The 49ers picked up their first loss of the season on Sunday, but it wasn't what the Falcons did that caused them to stumble.

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Oct 25 • 6:11 PM EDT • Health • foxsports.com
Walnut Ridge business starts coat drive for community

The Farm Service Tire Center in Walnut Ridge is hosting its first-ever coat drive, running now through Dec. 21.

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Oct 25 • 6:00 PM EDT • Business • kait8.com
Bengals Shut out in Disastrous First Half vs Ravens

The Cincinnati Bengals are off to a first half they’d like to forget. Cincy trails the Baltimore Ravens 13-0 in Baltimore.The story has been the Cincinnati Bengals’ defense which has been struggling against this Ravens offense.The Ravens got off to a hot start as Zay Flowers took a 48-yard pass to the house from backup […] The post Bengals Shut out in Disastrous First Half vs Ravens appeared first on HEAVY.

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Oct 25 • 5:33 PM EDT • Sports • sports.yahoo.com
British Columbia's new premier lucks into the job in unexpected political turn

An electoral gamble by the Canadian province's outgoing premier, David Eby, backfired as the provincial Conservatives take power for the first time since 1928.

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Oct 25 • 4:58 PM EDT • Politics • yahoo.com
BC's new premier lucked into the job in an unexpected political turn

An electoral gamble by the Canadian province's outgoing premier, David Eby, backfired as the provincial Conservatives take power for the first time since 1928.

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Oct 25 • 4:58 PM EDT • Politics • bbc.com
Here's how Bengals' second half vs Ravens made NFL history

The Cincinnati Bengals became just the 10th team in NFL history to get shut out in the first half and then score 35 points or more in the second half.

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Oct 25 • 4:49 PM EDT • Sports • sports.yahoo.com
Here's how Bengals' second half vs Ravens made NFL history

The Cincinnati Bengals became just the 10th team in NFL history to get shut out in the first half and then score 35 points or more in the second half.

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Oct 25 • 4:49 PM EDT • Sports • sports.yahoo.com
Remembering Freddie Freeman’s Iconic Walk-Off Grand Slam

Los Angeles Dodgers first baseman Freddie Freeman hit one of the most important home runs in Dodgers history two years ago, today.

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Oct 25 • 4:42 PM EDT • Sports • sports.yahoo.com
2026's First $1 Billion Movie Finally Confirms Netflix Release Date
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Oct 25 • 4:34 PM EDT • Entertainment • yahoo.com
USC Drops Out of AP Top 25 Poll After Wisconsin Loss, UCLA Rises Again

Both the USC Trojans and the UCLA Bruins had their rankings in the Associated Press Top 25 poll following their results from Saturday. View this post on Instagram A post shared by LA Sports Report (@lasportsreport) What Happened to USC’s Ranking? Following their loss to Wisconsin on Saturday, USC dropped out of the Top 25. […] The post USC Drops Out of AP Top 25 Poll After Wisconsin Loss, UCLA Rises Again appeared first on LA Sports Report.

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Oct 25 • 3:07 PM EDT • Sports • sports.yahoo.com
Kaine, Randall tour county's new Crisis Receiving and Stabilization Center

The Loudoun County Crisis Receiving and Stabilization Center's first day of operations on Oct. 22 included a tour by Sen. Tim Kaine, D-Va., and county Board of Supervisors Phyllis J.

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Oct 25 • 3:00 PM EDT • Health • loudountimes.com
Heidi Klum frightens fans, teases Halloween costume with bizarre close-up of strange prosthetic

The Queen of Halloween herself Heidi Klum is offering fans a first look at this year’s Halloween costume. As usual, it involves some pretty bizarre prosthetics.

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Oct 25 • 2:37 PM EDT • Entertainment • ew.com
Nintendo reveals why you don't actually fight Bowser in Super Mario Bros. 1

Nintendo’s Shigeru Miyamoto has shared some insight into why players don’t actually fight Bowser in the original Super Mario Bros. Miyamoto was present at a press conference at the end of the week to celebrate him becoming the first developer to win Japan’s Order of Culture award. During the event, he was asked to share behind-the-scenes stories about the making...

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Oct 25 • 2:15 PM EDT • Technology • nintendoeverything.com
Knicks Have Clear Advantage Over Magic With Lopsided Injury Report

The New York Knicks look for their first win of the season.

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Oct 25 • 1:36 PM EDT • Sports • sports.yahoo.com
Google's privacy policy now has a loophole for using your Gmail and Photos data in ads

The change sits in Google's updated privacy policy, which took effect on October 16 and was first spotted by Android Authority. The policy has long said, "We...

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Oct 25 • 1:33 PM EDT • Technology • techspot.com
Elon Musk’s Grok Releases First AI-Generated “Odyssey” Episode

Months after Elon Musk promised that Grok Imagine would make an entirely AI “Odyssey” film, the tech mogul has partially followed through.

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Oct 25 • 1:22 PM EDT • Technology • variety.com
Lakers at Jazz: What to watch in first road game

Walker Kessler needed only two games to show how much he could change the Los Angeles Lakers' frontcourt.

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Oct 25 • 1:20 PM EDT • Sports • sports.yahoo.com
☹️ Negative (-14%)
Steelers beat Saints to win first NFL game in Paris

The Pittsburgh Steelers defeated the New Orleans Saints 16-10 on Sunday to win the first-ever NFL regular season game in Paris. The low-scoring game had only one touchdown for each team.

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Oct 25 • 1:03 PM EDT • Sports • sports.yahoo.com
Clayface Takes First Place While Holmes Documentary Grows in Week Two

Clayface opened with $24.5M, while A24's three-hour Elizabeth Holmes documentary You Can See Everything grew 25% in its second weekend.

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Oct 25 • 12:47 PM EDT • Entertainment • northeasttimes.com
Lakers 1st-Round Draft Pick Floated as Trade Piece

The Los Angeles Lakers are off to a fast start. Could it be time to weigh trading away some young pieces to boost the rotation? The post Lakers 1st-Round Draft Pick Floated as Trade Piece appeared first on HEAVY.

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Oct 25 • 12:29 PM EDT • Sports • sports.yahoo.com
😐 Neutral (0%)
ESMO: Roche touts ‘convincing’ phase 3 KRAS data after win over rivals

Roche has shed more light on its investigational KRAS G12C inhibitor's phase 3 victory over Amgen’s Lumakras and Bristol Myers Squibb’s Krazati. The open-label Krascendo 1 trial enrolled 338 people with previously treated KRAS G12C-mutated non-small cell lung cancer (NSCLC). Patients who had already received a KRAS G12C inhibitor or pan-KRAS/RAS inhibitor were excluded from the trial. Participants received either divarasib once daily, Lumakras once daily or Krazati twice daily. Roche announced back in July that divarasib had demonstrated statistically significant improvements in progression-free survival (PFS) and overall survival (OS), meeting the trial’s primary and key secondary endpoints. But the Swiss pharma had been holding back the detailed data until now. At the European Society for Medical Oncology (ESMO) Congress in Madrid, Roche revealed that median OS for the 167 patients who received divarasib was 17.7 months, compared to 12 months for the 171 patients who received Lumakras or Krazati. The benefit was similarly clear when it came to median PFS, which stood at 9.8 months versus 5.7 months, respectively. A total of 44% of patients receiving divarasib were alive without disease progression at one year, compared to 24% of the control group, according to Roche’s presentation. It was a similar story for the objective response rate, which came in at 58% for divarasib versus 32% for the control group, while median duration of response was 11.9 months versus 6.9 months. Stefan Frings, M.D., Ph.D., deputy chief medical officer at Roche Pharma, told Fierce that the data made for a “very comprehensive, strong package, which should be convincing to health authorities.” “It’s an important advance for patients with lung cancer,” Frings said in an interview at a Madrid hotel during the conference. “It's a second-line setting, and patients who receive divarasib benefit compared to the current first-generation KRAS G12C inhibitors by having far longer overall survival,” he continued. “They live longer. They have better progression-free survival, better response rates, and with a safety profile which is—if [anything]—even better,” he said. According to Roche, 4.8% of patients receiving divarasib discontinued treatment due to treatment-related adverse events, compared to 11.7% in the control group. Serious treatment-related adverse events were also less common with divarasib, at 7.8% versus 15.2%. Roche’s confidence in divarasib had been building even before this phase 3 success. The candidate had already shown better potency and selectivity than the incumbent KRAS G12C inhibitors Krazati and Lumakras in preclinical tests. After cross-trial comparisons suggested that the edge translated into better clinical outcomes, Roche axed a study comparing divarasib to the chemotherapy docetaxel and went toe-to-toe with Lumakras and Krazati. “We designed the drug on purpose with higher potency and better selectivity,” Frings explained. “So, based on preclinical models, we clearly knew it would be superior to the first generation.” “It’s honestly not so frequent that pharma companies go head-to-head,” he added. “But if you want to make a point, if you want to convince payers, prescribers and patients … then a head-to-head win is rather rewarding.” While Amgen and BMS reached the regulatory finish line first for KRAS G12C-mutated, locally advanced or metastatic NSCLC in 2021 and 2022, respectively, they have struggled to capitalize on their head start. Krazati brought in $55 million for BMS in the second quarter, while Lumakras delivered $111 million to Amgen. For its part, Roche is aiming for peak divarasib sales of 1 billion to 2 billion Swiss francs ($1.2 billion to $2.5 billion), according to Frings. The Big Pharma is currently recruiting patients into a phase 3 trial comparing divarasib plus Keytruda against Keytruda plus chemotherapy in previously untreated advanced or metastatic nonsquamous KRAS G12C-mutated NSCLC. Roche has previously suggested that sales in metastatic disease would account for most of the forecast. Frings was tight-lipped on the exact timeline for a regulatory filing but said the Swiss pharma is “certainly keen to get this to as many patients as possible around the world.” Roche has more RAS drugs coming up behind divarasib. The pharma has already launched phase 1 trials of a pan-RAS inhibitor called RG6505 and a KRAS G12D inhibitor dubbed RG6620 in solid tumors. Roche’s partner Chugai Pharmaceutical is also testing a pan-KRAS inhibitor called AUBE00. Roche has made a “deliberate effort” to test a range of RAS drugs, Frings said. “If you have many rare mutations and you are scrambling to find sufficient patients, a pan-RAS inhibitor makes a lot of sense,” he explained.

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Oct 25 • 11:30 AM EDT • Health • fiercebiotech.com
Cam Skattebo Update: Will Giants Star RB Play Against Texans?

New York Giants share news on RB Cam Skattebo after benching in Week 6. The post Cam Skattebo Update: Will Giants Star RB Play Against Texans? appeared first on HEAVY.

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Oct 25 • 11:18 AM EDT • Sports • sports.yahoo.com
Evaluating DJ Herz After Bouncing Back from Injury with Nationals

After making his first MLB appearance in nearly two years, what should the Washington Nationals expect from DJ Herz in his third season with the organization?

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Oct 25 • 10:56 AM EDT • Sports • sports.yahoo.com
Jayson Tatum Reacts to Encouraging Celtics Development Against Knicks

The Boston Celtics beat the New York Knicks 107-103 on Friday night at TD Garden. Jayson Tatum scored 36 points and closed the game with a run that sealed the win. The stat line told the obvious story.But after the game, the moment Tatum wanted to talk about was not one of his own. It […] The post Jayson Tatum Reacts to Encouraging Celtics Development Against Knicks appeared first on HEAVY.

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Oct 25 • 10:17 AM EDT • Sports • sports.yahoo.com
Amid first 0-3 start since 2007, Giannis-led Heat searching for answers: ‘We’re not in panic mode’

The Heat’s Giannis Antetokounmpo era is off to a rough start.

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Oct 25 • 10:16 AM EDT • Sports • miamiherald.com
Preview

The Men's First Team are back in Serie A action, this time heading south to face Lecce in Puglia.The Serie A Matchday 8 clash is set to take place at the Stadio Via del Mare at 18:00 CET on Sunday, Oc...

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Oct 25 • 10:15 AM EDT • Sports • sports.yahoo.com
Hints About Why Sabres Missed Connor Hellebuyck

The fact that the Buffalo Sabres missed out on Connor Hellebuyck could linger painfully for a while if the goalie play in Western New York doesn’t improve in a hurry. It’ll hurt all the more because the reports over the summer indicated that for at least a time, the Sabres were the frontrunners to pull […] The post Hints About Why Sabres Missed Connor Hellebuyck appeared first on HEAVY.

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Oct 25 • 9:52 AM EDT • Sports • sports.yahoo.com
Business Briefcase: Open-air downtown farm market continues

SHENANDOAH — Schuylkill County’s longest running seasonal outdoor downtown farm market continues its popular run 8 a.m. to noon Tuesdays and Fridays through November along the east side of the first block of South Main Street. Launched in t…

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Oct 25 • 9:00 AM EDT • Business • republicanherald.com
Tickets on sale now for 49 Winchester's Charlottesville show next year

49 Winchester, a homegrown Virginia country rock band, is the first band announced for Ting Pavilion's 2027 lineup. Tickets are on sale now.

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Oct 25 • 9:00 AM EDT • Entertainment • dailyprogress.com
‘Dream big’: The Seattle-area kids and teens launching businesses

Some among the Seattle area's Generation Z and Alpha age groups are diving headfirst into entrepreneurship.

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Oct 25 • 9:00 AM EDT • Business • seattletimes.com
Browns QB Shedeur Sanders Pegged for Deadline Exit

The Browns are approaching a quarterback decision that could reshape their roster before the trade deadline. The post Browns QB Shedeur Sanders Pegged for Deadline Exit appeared first on HEAVY.

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Oct 25 • 8:39 AM EDT • Sports • sports.yahoo.com
I Tried TikTok’s Viral Pea Salad to ‘Fibermaxx’ My Lunch—and It Didn’t Quite Go According to Plan

There can be too much of a good thing, as my gut found out firsthand.

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Oct 25 • 8:12 AM EDT • Health • prevention.com
😐 Neutral (0%)
Gyökeres May Not Be Scoring, But He’s Helping Arsenal Win

Viktor Gyökeres is still waiting for his first Premier League goal of the season, and for a striker of his reputation, that’s always going to attract attention.But are we becoming too focused on wh...

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Oct 25 • 8:00 AM EDT • Sports • sports.yahoo.com
Women's FA Cup clash against Rotherham United postponed

Following a pitch inspection at the BD Community Stadium, this afternoon's First Round Women's FA Cup clash between Leeds United Women and Rotherham United Women has been postponed.An update on the re...

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Oct 25 • 7:37 AM EDT • Sports • sports.yahoo.com
WSL: Crystal Palace host Chelsea in first of five games

Follow live coverage of Crystal Palace host Chelsea in the first of five Women's Super League games on Sunday.

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Oct 25 • 7:12 AM EDT • Sports • sports.yahoo.com
Powers Health Community Hospital Achieves Statewide Milestone in Treating Heart Valve Conditions

Powers Health Community Hospital has successfully performed Indiana’s first procedure using the SAPIEN M3™ transcatheter mitral valve replacement (TMVR) system, a minimally invasive treatment for …

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Oct 25 • 7:00 AM EDT • Health • buildingindiana.com
Gov. Meyer announces the inclusion of the Verizon BEAD Project

Governor Matt Meyer announced the addition of the Verizon Broadband Equity, Access, and Deployment (BEAD) project to the JobsFirst Accelerator program.

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Oct 25 • 5:30 AM EDT • Business • wdel.com
😐 Neutral (0%)
Steelers vs Saints live updates, TV info, start time, stream NFL Paris game

The Steelers are in the middle of a AFC North divisional dog fight as they look to win the first NFL regular season game on French soil.

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Oct 25 • 5:00 AM EDT • Sports • sports.yahoo.com
Dana White Praises Merab Dvalishvili After UFC 333

UFC president Dana White praised bantamweight fighter Merab Dvalishvili following his fight against Petr Yan at UFC 333.In the trilogy championship bout between Yan and Dvalishvili, the two long-time rivals went the full 25 minutes and put on an absolute show as they went back and forth for five rounds before Yan ultimately edged out […] The post Dana White Praises Merab Dvalishvili After UFC 333 appeared first on HEAVY.

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Oct 25 • 4:53 AM EDT • Sports • sports.yahoo.com
Vikings Handed Realistic Trade Idea for Colts’ Jonathan Taylor

The Minnesota Vikings are one of the potential trade destinations in the speculation conversation regarding Indianapolis Colts running back Jonathan Taylor. Moreover, the Vikings could push the Colts to become sellers if they defeat them in Week 7.If Minnesota does move to 6-0 and pushes the Colts to put up a “For Sale” sign on […] The post Vikings Handed Realistic Trade Idea for Colts’ Jonathan Taylor appeared first on HEAVY.

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Oct 25 • 3:53 AM EDT • Sports • sports.yahoo.com
Hurricanes Tried to Acquire Forward in Hellebuyck Trade Push

The Carolina Hurricanes tried to land a forward, as they looked to make a serious push for Connor Hellebuyck. The post Hurricanes Tried to Acquire Forward in Hellebuyck Trade Push appeared first on HEAVY.

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Oct 25 • 1:59 AM EDT • Sports • sports.yahoo.com
Warriors fall to 0-3 for first time of Stephen Curry's career with loss to Suns
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Oct 25 • 1:06 AM EDT • Sports • sports.yahoo.com
Takeaways from BYU’s Exhibition Win Over UNLV

BYU finished off its preseason slate with an 89-77 exhibition road win over UNLV Saturday afternoon in Las Vegas. BYU won a closed scrimmage 102-53 versus Long Beach State, beat Nebraska 72-61 last week, and closed things out with a double-digit win over the Rebels. BYU trailed 42-30 late in the first half, but ended […]

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Oct 25 • 12:59 AM EDT • Sports • sports.yahoo.com
😐 Neutral (26%)
love
67%
wow
33%
Leafs’ Gavin McKenna Reveals True Thoughts On Connor McDavid

The Toronto Maple Leafs and Edmonton Oilers are facing one another in a Saturday evening showdown at Edmonton’s Rogers Place, marking the first time in the career of rookie forward Gavin McKenna that he’s facing Edmonton superstar captain Connor McDavid.McKenna, who has previously trained with McDavid over the summer, remains as much in awe of […] The post Leafs’ Gavin McKenna Reveals True Thoughts On Connor McDavid appeared first on HEAVY.

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Oct 25 • 12:30 AM EDT • Sports • sports.yahoo.com
🙂 Positive (32%)
Instagram Launches Apple TV App With Reels and More

Instagram is now available on the Apple TV, bringing Reels, longer videos, and live shows via the platform to Apple's streaming device for the first time. The Instagram app for Apple TV lets users watch content from their favorite creators, discover videos, and resume watching across devices. Instagram describes the app as a way to watch together with friends and family, extending its video experience to the television. The app appears to have launched on October 23.

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Oct 25 • 12:27 AM EDT • Technology • macrumors.com
Browns sign Maliek Collins to $30 million extension

The Cleveland Browns have secured one of their standout defensive players for the future before their next game against the Tennessee Titans . Cleveland defensive tackle Maliek Collins has agreed to a two-year contract extension worth $30 million. According to NFL insider Ian Rapoport, Collins’ agent, Drew Rosenhaus, confirmed the agreement to him […] The post Browns sign Maliek Collins to $30 million extension appeared first on ClutchPoints.

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Oct 25 • 12:26 AM EDT • Sports • sports.yahoo.com
Kochetkov Earns Shutout

Pyotr Kochetkov improved his record to 7-0-0 with a 24 save shutout and the Carolina Hurricanes defeated the St. Louis Blues on Saturday night, 4-0. The Hurricanes now have a 9-2-2 record and their 20 points put them at first place in the league, (for now). The Canes finished up their road trip with a […]

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Oct 25 • 12:16 AM EDT • Sports • sports.yahoo.com
☹️ Negative (-13%)
ahah
100%
Argentina should host World Cup

SPAIN are a coming force in world rugby and I welcome their bid to host the World Cup. However I think Argentina should win the vote as they have been a true force on the world stage for a long time. It would be ground breaking to take the event to South America. Either bid […] The post Argentina should host World Cup appeared first on The Rugby Paper .

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Oct 24 • 11:59 PM EDT • Sports • sports.yahoo.com
1 player Eagles must target at 2026 NFL trade deadline

If the Philadelphia Eagles make any more trades before the 2026 trade deadline , it should almost certainly be as sellers, not buyers. Now sure, could Roseman find a bargain on the margins and make a move, like if a team is willing to take a conditional seventh-round pick for a player at a position of need – safety, anyone? -instead of releasing […] The post 1 player Eagles must target at 2026 NFL trade deadline appeared first on ClutchPoints.

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Oct 24 • 11:53 PM EDT • Sports • sports.yahoo.com
Latest Karl-Anthony Towns Update is Good News For Warriors

The Golden State Warriors need to find creative routes to improve the roster with Stephen Curry starting to hit the late chapters of his career. NBA pundits have started to question whether the New York Knicks will retain Karl-Anthony Towns. Recent reports have shown Towns and the Knicks far apart on the extension talks of […] The post Latest Karl-Anthony Towns Update is Good News For Warriors appeared first on HEAVY.

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Oct 24 • 11:52 PM EDT • Sports • sports.yahoo.com
Rui Hachimura Showed Love To Lakers After Clippers Debut

The end of Rui Hachimura’s time with the Los Angeles Lakers saw him choosing to sign with the same town rival. Hachimura joined the Los Angeles Clippers in NBA free agency and played his first game against the Lakers last night. Despite losing the game, Hachimura was in positive spirits afterwards when asked about the […] The post Rui Hachimura Showed Love To Lakers After Clippers Debut appeared first on HEAVY.

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Oct 24 • 11:11 PM EDT • Sports • sports.yahoo.com
Michigan’s Kyle Whittingham Pinpoints 3 Costly Failures Behind Indiana Loss

The Michigan Wolverines had enough defensive resistance to push Indiana into overtime, but their offense never supplied the breakthrough needed to finish the job. Following the 13-6 defeat, coach Kyle Whittingham offered a straightforward explanation of where the game slipped away. His assessment centered on three problems that Michigan could not overcome.Whittingham pointed to the […] The post Michigan’s Kyle Whittingham Pinpoints 3 Costly Failures Behind Indiana Loss appeared first on HEAVY.

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Oct 24 • 10:44 PM EDT • Sports • sports.yahoo.com
FAU star receiver achieves historic feat with 5-TD performance

The FAU Owls set themselves apart in college football history following a spectacular performance from Easton Messer in their 51-49 win over the Rice Owls on Saturday afternoon. Messer is going through the final season of his collegiate career, his second with the Owls. He shines as one of the best receivers in the nation, ranking high with a lot […] The post FAU star receiver achieves historic feat with 5-TD performance appeared first on ClutchPoints.

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Oct 24 • 10:33 PM EDT • Sports • sports.yahoo.com
Bethune-Cookman scores wild upset victory over Jackson State

The 2026 football season has delivered upsets and stunning losses, but this one might be the most shocking. Over the past two seasons, Bethune-Cookman has gained momentum as a formidable SWAC East contender, but it needed a definitive win over one of the conference’s top teams to prove its worth . Today, that victory came. Bethune-Cookman secured a […] The post Bethune-Cookman scores wild upset victory over Jackson State appeared first on ClutchPoints.

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Oct 24 • 10:14 PM EDT • Sports • sports.yahoo.com
Jacksonville Jaguars’ Major Offensive Issue After 4-2 Start Revealed

The Jacksonville Jaguars’ 4-2 start has been overshadowed by a recurring offensive problem, as penalties continue to erase scoring opportunities and disrupt drives. Costly infractions have prevented the team from maximizing its production, raising concerns about discipline as Jacksonville looks to remain competitive in the AFC. The Jaguars have already had three touchdowns wiped off […] The post Jacksonville Jaguars’ Major Offensive Issue After 4-2 Start Revealed appeared first on Gridiron Heroi

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Oct 24 • 10:12 PM EDT • Sports • sports.yahoo.com
Browns Star Denzel Ward Drops 2-Word Message on Injury

Denzel Ward offered a two-word update after a late-week hand injury, as the Browns received encouraging news on several other key defenders. The post Browns Star Denzel Ward Drops 2-Word Message on Injury appeared first on HEAVY.

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Oct 24 • 9:32 PM EDT • Sports • sports.yahoo.com
😐 Neutral (0%)
Bell County early voting reaches 42,964 ballots through Saturday

Bell County voters cast 7,523 ballots on Saturday, Oct. 24, pushing the cumulative early voting turnout to 42,964 through the first six days of voting.

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Oct 24 • 9:04 PM EDT • Politics • kdhnews.com