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UK powertrain company plants its North American headquarters in Southfield
A UK-based powertrain solutions company is planting its North American headquarters in Southfield.
Blizzard Entertainment Workers Ratify First Contracts
The deals require management to bargain over the use of AI in the workplace and enshrine layoff protections at the Microsoft-owned company.
Apple Reveals iPhone 18 Pro and iPhone 18 Pro Max Battery Capacities
Apple has confirmed the battery capacities for the iPhone 18 Pro and iPhone 18 Pro Max models that the company announced earlier today. Apple is required to publish energy labels on its iPhone product pages in the EU, and they reveal the official mAh battery capacities for the devices. Here are the battery capacities for the iPhone 18 Pro and iPhone 18 Pro Max models that still have a SIM card tray, according to Apple: iPhone 18 Pro: 4,056 mAh (+1.7% vs.
Almost 1,900 Blizzard workers ratify first union contract with Microsoft
Blizzard Entertainment has secured a first union contract with parent company Microsoft, ratified by a workforce vote c…
Three members of the ESPN/Disney family named to Sports Broadcasting Hall of Fame Class of 2026
Three members of The Walt Disney Company/ESPN family – former Disney Chairman and CEO Robert A. Iger, Monday Night Football analyst Troy
iPhone 18 Pro Models and iPhone Duo Feature Apple's New C2 Modem
Apple today unveiled new iPhone 18 Pro models and the iPhone Duo – the company's first foldable iPhone – and all three devices feature Apple's new custom-designed C2 modem for 5G connectivity. Prior to today's announcements, there was speculation that Apple's C2 in-house modem would not support mmWave 5G in the U.S., and that the company would once again rely on Qualcomm to fill the gap for American carriers. Apparently, that's not the case.
Maid 4 Time Forms Strategic Partnership with Local Business Rockstar to Elevate Cleaning Services
New York, Sept. 09, 2026 (GLOBE NEWSWIRE) -- Maid 4 Time, a leading house cleaning company, renowned for its top-rated cleaning services and exc...
Here's how iPhone Duo treats apps not optimized for the foldable display
Apple has officially announced the iPhone Duo, its first foldable display device. Additionally, the company has detailed how third-party apps...
Apple Unveils the iPhone Duo, a Foldable Phone That Costs $1,999
At the company’s annual September product event, Apple also demonstrated its work on artificial intelligence and other new devices.
Sacramento drive-in hosts free movie night with kid-friendly options. What to know
Discounts on nachos, bounce houses and other activities will accompany six free movies at the West Wind theater’s movie night.
Clearsight Advises Ambit in its Acquisition by Danforth Health
Clearsight Advisors, Inc. ("Clearsight") is pleased to announce a successful transaction in its Healthcare and Life Sciences Services practice. Clearsight served as the exclusive sell-side advisor to Ambit RD, Inc. (the "Company" or "Ambit") on its acquisition by Danforth Health, Inc. ("Danforth"), a portfolio company of Avesi Partners ("Avesi").
How Hollywood Shapes Our Understanding of Health
A study sponsored by Eli Lilly and Company (Lilly) shows that chronic illness is historically underrepresented on screen, while a growing coalition of studios, researchers, and patient advocates work to change that reality.
Paul Becht
Sheehan & Company is pleased to welcome Paul Becht, CPA, as Partner. Paul brings over 30 years of experience overseeing audits and reviews of
Amy Joyce
Sheehan & Company welcomes Amy Joyce, CPA, JD, as Director of Private Client Services. Amy brings 25+ years advising high-net-worth individuals,
Thunder Road Films and Lit Entertainment Group Launch TR/AK, Media Company Focusing on Original Stories and Creators
Thunder Road Films founder Basil Iwanyk and partner Erica Lee have partnered with Lit Entertainment Group founder Adam Kolbrenner to launch a new media company, TR/AK. The company will focus on creato...
Thunder Road Films and Lit Entertainment Group Launch TR/AK Media
Thunder Road Films and Lit Entertainment Group launch TR/AK media company
Johnsonville Votes For Sausage Over Political Ads - Midland
Johnsonville has jumped back into electoral politics, this time asking people to vote for something sensible: affordable protein for dinner. The humorous campaign targets viewer fatigue, as record spending on political ads threatens to drain the fun out of every last game, sitcom and streaming pleasure. This time, the company is throwing its hat in the ring for Dinner 2026. Backed by research it conducted with Harris Polls, Johnsonville has learned Americans are already overwhelmed by both politics and meal planning. Sausage is running the dinner race on a core promise to simplify dinner decisions, the company says.
Rabies testing concerns prompt investigation from Minnesota health officials
The Minnesota Department of Health is searching for customers of a Twin Cities company that it suspects has not been consistently submitting rabies tests for testing.
Persona 4 Revival coming to Switch 2 on May 20, 2027
ATLUS will release a Switch 2 version of Persona 4 Revival on May 20, 2027, the company announced.
Casey Affleck poses alongside eldest son Indiana, 22, during rare red carpet appearance
Indiana and younger brother Atticus, 18, appear in Casey’s new movie “Company.”
Paramount Business Jets Named Best Luxury Private Aviation Company in the USA for 2026
Luxury Lifestyle Awards recognizes Paramount Business Jets for excellence in private aviation and its longstanding commitment to safety, transparency and personalized service Richard Zaher, Founder and CEO of Paramount Business Jets. Paramount Business Jets was named Best Luxury Private Aviation Company in the USA for 2026 by Luxury Lifestyle Awards. Photo courtesy of Paramount Business Jets. ASHBURN, Va., Sept. 09, 2026 (GLOBE NEWSWIRE) -- Paramount Business Jets, an award-winning global privat
Apple event live updates: New CEO to debut first foldable iPhone, new watch series, and more
Follow Apple’s Sept. 9 event live for new product announcements, prices, release dates and the company’s first launch under CEO John Ternus.
I've Watched Four Tech Hype Cycles. Companies Are Botching AI the Same Way.
Simply adding AI language to your brand does not automatically make your company more relevant or more compelling.
Webinar: The Massive Scale of GLP-1s: Evolving Health, Healthcare and Markets
Watch this discussion on how GLP-1 drugs for obesity are changing the shape of U.S. healthcare. From direct-to-consumer portals to pharmacy deals, how these drugs reach patients is changing—and leading to debates over pricing and coverage. Learn how your company can be both patient-forward while also maximizing revenue in this unique environment.
Apple Shares Mysterious Teaser Video Before 'iPhone Duo' Event Today
Apple will be holding an event today starting at 10 a.m. Pacific Time, with the company expected to unveil new iPhones and much more. Ahead of the event, Apple's new CEO John Ternus just shared a mysterious teaser video. The short clip appears to show a beam of light that is shining onto the edge of an iPhone. The light is coming from a hexagonal shape that changes size, which could hint at the iPhone 18 Pro's rumored mechanical aperture upgrade.
Luma locks down 15-year, $410M fund for life science investments
Luma Group today announced the final close of its inaugural life sciences venture capital fund, totaling $410 million. The New York-based investment firm has had a grip on life sciences since its founding in 2023. The funds unveiled today, dubbed LumaBio Fund I, include investments that have already been made into more than 10 biotechs. They include the likes of eye disease-focused Character Biosciences, rebranded Belgian biotech Coultreon Biopharma and cellular rejuvenation company Altos Labs. The fund saw early success when one of the companies it co-founded, called Vaccine Company, was picked up by Eli Lilly earlier this year for up to $1.55 billion. The acquisition of the in vivo nanoparticle technology-focused biotech formed part of a trio of vaccine buys for the Big Pharma, which has itself been on a prolonged spending spree in 2026. Luma's fund is structured as a 15-year investment with plans to support groundbreaking science and support companies through key milestones from discovery to commercialization, Luma explained in the release. "We founded Luma Group on the belief that extraordinary science, supported by patient, long-term capital, has the power to improve millions of lives," Joshua Fink, founder and managing member of Luma Group, said in the release. "This fund represents more than capital—it is a commitment to partnering with extraordinary innovators as they translate visionary science into life-changing medicines."
ASL Environmental Sciences Brings ADCP Training To PRODIGY Field School
ASL Environmental Sciences equipped graduate students with hands-on ADCP mooring experience at the 2026 PRODIGY field school in Bamfield, British Columbia, covering the full cycle from mooring design and deployment to data analysis. The company plans continued involvement through 2028.
After Years Of Company Stalling, Blizzard Workers Win Mega-Contract That Applies To All Unionized Teams
"Really strong" layoff protections are just the tip of the iceberg
Gracenote Expands AI Product Roadmap with Sports MCP Server, Entertainment SLM and Agents
/PRNewswire/ -- Gracenote, Nielsen's content intelligence business, today unveiled the next phase of its AI product roadmap. Anchored by its Video Model...
Newmark Advises Havas Health in 254,000-Square-Foot Headquarters Expansion & Extension at 200 Madison Avenue
/PRNewswire/ -- Newmark Group, Inc. (Nasdaq: NMRK) ("Newmark" or the "Company"), a leading commercial real estate advisor and service provider to large...
H1 acquires Defacto Health to expand provider network intelligence
H1 has acquired Defacto Health, a healthcare data company focused on provider network intelligence, in a move to expand its offerings for health plans and strengthen its healthcare data assets. | H1 has acquired Defacto Health, a healthcare data company focused on provider network intelligence, in a move to expand its offerings for health plans and strengthen its healthcare data assets.
Parlance Brings Verified Push Notification Security to Health System IT Help Desks on ServiceNow Store
/PRNewswire/ -- Parlance, a healthcare voice AI company, today announced the availability of its help desk intelligent virtual assistant (IVA) on the...
Elysium Health™ Officially Opens The Elysium Longevity Institute™ (TELI), Establishing a New Standard for Longevity Medicine
/PRNewswire/ -- Elysium Health, Inc.™, the leading longevity science company, today announced the opening of The Elysium Longevity Institute™ (TELI), marking...
Clearway Health Scales Operational Excellence with Appointment of Chief Operating Officer
/PRNewswire/ -- Clearway Health, a company that partners with hospitals and health systems to plan, build and operate specialty pharmacy programs, announces...
Prisma Health Extends Tecsys Partnership from Distribution Center to Bedside
/PRNewswire/ -- Tecsys Inc. (TSX: TCS), an industry-leading supply chain management company, today announced that Prisma Health, the largest private, nonprofit...
AT&T Business and Amazon Leo form strategic partnership
AT&T Business and Amazon Leo have agreed to bring broadband services to AT&T Business customers nationwide, making AT&T is the first major U.S. telecom provider to offer converged connectivity solutions that include Amazon Leo’s low Earth orbit (LEO) satellite services. With the agreement, AT&T Business customers have multiple access connectivity options, which the company said […]
Telemedicine company offers GLP-1s for addiction
A CDC Covid restructuring, public trust in Fauci, and more health news from Morning Rounds
Wheeling pet care business halts van service after dog’s death
Waggles Pet Resort intends to “evaluate steps to help prevent a tragedy like this from ever happening again,” the company announced in a prepared statement.
Aurora Appoints Seasoned Biopharmaceutical Executive to Lead Commercial Acceleration of Global Medical Cannabis Business
/PRNewswire/ -- Aurora Cannabis Inc. (NASDAQ: ACB) (TSX: ACB), the Canadian-based leading global medical cannabis company, announces Faris El Refaie, a...
Estes Construction announces Q3 Community Impact Grant Award recipients
Estes Construction has announced grants to 12 organizations for the third quarter through its Community Impact Grant Awards program. According to a news release, the recipients reflect the company’s four giving pillars: Underserved youth, partnering with purpose, talent and workforce, and regional vitality. Through its community impact grants, Estes works to expand opportunities, strengthen communities,…
Samsung 'advice' to Apple suggests it fears the build quality of the iPhone Duo
Samsung says it welcomes Apple’s entry into the foldable smartphone market, although the company appears to feel threatened by the...
Ingenovis Health names new chief commercial officer
Nicole Gable joins Ingenovis Health as chief commercial officer to lead strategy for the Blue Ash-based health workforce staffing company.
Ingenovis Health names new chief commercial officer
Nicole Gable joins Ingenovis Health as chief commercial officer to lead strategy for the Blue Ash-based health workforce staffing company.
Health In Tech Named to Newsweek's America's Greatest Mid-Market Companies 2026
Health In Tech, Inc. (Nasdaq: HIT), an AI-enabled InsurTech platform company, announced today that it has been named one of Newsweek's America's Greatest Mid-Market Companies 2026.
This week in Santa Cruz County business: Paystand branches into AI agents; court hearing for former Scotts Valley executive; Barilla snaps up Goodles
In this week's survey of local business, Jessica M. Pasko reports on the rollout of a new AI tool for Santa Cruz-based fintech company Paystand, notes a court date for a former executive of Scotts Valley's Ambient Photonics and runs down other numbers, names and dates to know.
Maven Securities LTD Purchases New Position in Caesars Entertainment, Inc. $CZR
Maven Securities LTD acquired a new stake in Caesars Entertainment, Inc. (NASDAQ:CZR - Free Report) in the 2nd quarter, according to the company in its most recent 13F filing with the Securities and Exchange Commission (SEC). The institutional investor acquired 283,136 shares of the company's stoc
Maven Securities LTD Makes New $2.28 Million Investment in Live Nation Entertainment, Inc. $LYV
Maven Securities LTD acquired a new stake in Live Nation Entertainment, Inc. (NYSE:LYV - Free Report) during the second quarter, according to its most recent disclosure with the SEC. The institutional investor acquired 12,470 shares of the company's stock, valued at approximately $2,283,000. Other
Gilead opens new research centre bringing together oncology, inflammation and research data science teams
The centre in California supports the company’s $32bn US investment
Company that pledged 200 jobs in Charlotte leaves town for SC, loses NC incentives
The company, known for brands like Dirt Devil, announced a $5 million investment in 2015.
Before You Rebrand Your Company, Answer These 4 Questions About the Business
Dunkin’ and Calendly changed their identities only after their businesses had evolved.
Summerville-based clothing store agrees to pay Buc-ee’s $850,000
Born United, a clothing company based out of Summerville, agreed to settle its lawsuit with Buc-ee’s and pay the gas station giant $850,000 for using and selling apparel featuring its iconic beaver logo without permission.
SC clothing store agrees to pay Buc-ee’s $850,000 in trademark lawsuit
Born United, a clothing company based out of Summerville, agreed to settle its lawsuit with Buc-ee’s and pay the gas station giant $850,000 for using and selling apparel featuring its iconic beaver logo without permission.
Wellington Management Group LLP Acquires Shares of 406,352 PENN Entertainment, Inc. $PENN
Wellington Management Group LLP bought a new position in shares of PENN Entertainment, Inc. (NASDAQ:PENN - Free Report) in the 2nd quarter, according to its most recent 13F filing with the Securities & Exchange Commission. The institutional investor bought 406,352 shares of the company's stock
96,800 Shares in Caesars Entertainment, Inc. $CZR Acquired by Governors Lane LP
Governors Lane LP acquired a new position in Caesars Entertainment, Inc. (NASDAQ:CZR - Free Report) during the second quarter, according to the company in its most recent filing with the Securities & Exchange Commission. The institutional investor acquired 96,800 shares of the company's stock,
Here is what to do if healthcare costs are eating into your raises
An insurance executive explains how soaring healthcare costs eat into raises, and how workers should discuss alternative options with their company.
NiteShyft Announces October Launch of AI Business Operating Platform for Small Companies
NiteShyft will open its AI business operating platform to the public in October 2026, following private testing in which AI agents completed more than 2,000 business tasks at a median speed 736 times faster than benchmark estimates, according to company records.Dubai, United Arab Emirates--(Newsfile Corp. - September 8, 2026) - NiteShyft today announced that its business operating platform will open to the public in October 2026, following a private testing period in which the platform executed.
Carmignac Gestion Buys Shares of 100,508 Caesars Entertainment, Inc. $CZR
Carmignac Gestion bought a new position in shares of Caesars Entertainment, Inc. (NASDAQ:CZR - Free Report) during the 2nd quarter, according to the company in its most recent 13F filing with the Securities & Exchange Commission. The institutional investor bought 100,508 shares of the company'
SteelSeries Brings Its Outstanding Infinite Battery System to Controllers With the Aeon Pro for Xbox and PC, But Is It Worth the Sky-High Price Tag?
The SteelSeries Aeon Pro packs in just about every "pro" feature you could ask for in a controller, with Hall-effect thumbsticks, tactile switch buttons, adjustable triggers, and the company's outstanding hot-swappable battery system.
Blackstone explores sale of ZO Skin Health, sources say
Investment firm Blackstone is looking to sell medical-grade skincare company ZO Skin Health, which could be valued at around $2 billion in any deal, according to people familiar with the matter.
William O'Dowd IV Discloses Investment at Dolphin Entertainment with 19.0% Stake
William O'Dowd IV, the CEO of Dolphin Entertainment, Inc., reported beneficial ownership of 19.0% of the company's common stock. He filed a Schedule 13D on Sep. 08, 2026, after an earlier note exchange and a pre-set buying plan in 2025. The position includes common shares and the right to convert c…
Pittsburgh entrepreneur donates storage systems to Seton Hill business, technology school
The founder of a Pittsburgh-based digital storage solutions company donated $35,000 worth of equipment to Seton Hill’s cybersecurity and computer science programs. Gene Leyzarovich, former Jetstor CEO, founded the Bloomfield company more than 30 years ago while studying at the University of Pittsburgh and working night shifts at UPMC. The
Crossland Construction Lab opens at Bentonville High School
Area schools are working with construction companies to introduce students to industry jobs through construction programs as demand for workers rises. A construction company executive hopes the programs will lead...
Exclusive: Two of gaming’s biggest names are making a big investment in gaming’s future
The first thing to know about the Nova Games Foundation is that it isn’t about The Game Awards. And it’s not about PlayStation. The ambitious new grant program is the brainchild of Geoff Keighley and Mark Cerny. Keighley is the host of The Game Awards, Summer Game Fest and Opening Night Live. Cerny is a game designer of some 45 years and the lead architect for the PlayStation 4 and 5. But this new thing, which they’re revealing through Game File, isn’t about their day jobs. It’s an unaffiliated, standalone philanthropic project. It’s a bet on the artistic future of video games and a way, they tell me, to give back. “I’m nearing the end of my career,” Cerny recently told me over email. “I’m not done yet, but paying it forward—in the best way possible—is very much on my mind these days,” The Nova Games Foundation is a university-affiliated fellowship program, intended to offer six-figure grants to 20 young game designers each year, potentially for decades to come. It will offer no-strings-attached funding along with mentorship from games industry leaders, a combination intended to aid the development of groundbreaking new games, Cerny and Keighley told me. Nova will begin accepting applications in December, from class of 2026 and 2027 students from 13 affiliated gaming programs at universities in eight countries. The schools working with Nova include the New York University and the University of Southern California in the U.S., along with Abertay University in Scotland, Cnam-Enjmin in France, TH Köln in Germany, and the Royal Melbourne Institute of Technology in Australia, Cerny and Keighley said. The plan: $100,000 per recipient, with about a quarter of Nova fellows eligible for up to $500,000 more for projects that are shaping up particularly well. Payments will be delivered based on development milestones, and recipients will own their games. Nova will help promote the work, and developers will be free to pursue the publishers and platforms of their choice. Nova can help introduce fellows to publishers, but won’t take a cut. “I’ve always wanted to give back, but given my role in the industry, I’ve never felt it appropriate to commercially invest in games,” Keighley told Game File. “I’ve never owned stock in a game company or taken a financial stake in a game. Nova is philanthropy: we aren’t taking equity or looking to recoup the grants. The return we’re hoping for is creative—helping new voices make games and find their footing. “Mark and I have each made multi-million-dollar donations to establish the foundation, and we intend to keep contributing. We hope others will join us.” Cerny and Keighley have already hired an executive director, John Maconga, and a head of grants, recent Game Developers Conference director Ashley Corrigan, to help launch the effort. They’re working to recruit game industry leaders to join the effort. Keighley says “dozens of leading game directors have already expressed interest in contributing their time.” To name one, they’ve already gotten Josef Fares, lead designer from It Takes Two and Spit Fiction studio Hazelight on board with a donation and pledge to help out. “I’m proud to support Nova because it gives the next generation of creators the freedom to explore their creativity and hopefully bring their unique visions to life,” Fares told Game File. A plan forged from a friendship Keighley and Cerny have known each other a long time. It’s been so long, Cerny isn’t even sure exactly when they met. “We travel in much the same circles and I’m sure first intersected in the 90s or early 2000s,“ Cerny said. Keighley thinks it might have been during his stint writing a column about the mid-’90s console 3DO for a gaming magazine while Cerny was working on games with Crystal Dynamics or on Way of the Warrior with Naughty Dog. They became genuine friends about a 10 years ago, Keighley said, as they bonded over a shared love of games and a hope to improve the industry. “About a decade ago, we started having dinner a few times a year in LA,” Keighley said. “Just to catch up on life and the industry. Those conversations continued over Zoom during COVID. Nova grew out of that friendship and a question we kept coming back to: ‘What could we do to help the next generation of game directors get started?’” Keighley credits Cerny with the idea to figure out a way to put their money and time back into the industry. At one of those dinners, Keighley proposed the idea of a fellowship program. He’d recalled applying for a Rhodes Scholarship when he was younger. “Spoiler: I didn’t get it,” he said. He’d admired the MacArthur Foundation’s so-called “genius grants.” He liked these kinds of programs that recognized people’s talents and gave them the financial boost and the freedom to realize their potential. With Cerny, he had pondered what a game industry version of that could be. Keighley liked the idea of centering the fellowship on students, drawing inspiration from the accomplishments of Jenova Chen, the USC game design graduate who went on to lead the creation of gently moving, ambitious games such as Flower and Journey. Keighley also thought it could be useful to help promising graduates bridge the transition from student to professional. “Joining an established studio isn’t always possible—especially in today’s market—and even then, it isn’t the right path for everyone,” Keighley said. A fellowship, he realized, could give “graduates the time, resources and guidance to pursue a game of their own and not worry about the commercial viability.” As the idea took shape, Cerny also saw an opportunity to enable more games of a certain type: “The target with the grants is games as an artistic medium,” Cerny told me. “We like to say games with ‘artistic, literary and societal value.’” He added: “I’m a pretty big gamer myself, though I tend to gravitate towards the smaller and more unique or artistic titles, games like Neva, Abzu, Gorogoa, Stray or Outer Wilds. I was just playing and Roger on a flight to Japan, and was getting misty eyed to a degree that I was concerned that a flight attendant would ask me if I was OK. “So one fun benefit here is the games that will come out of the Nova Games Foundation – I can’t wait to play them myself.” Cerny believes it will also be useful for Nova fellows to hone their craft and team leadership skills. “We are looking for the next generation of visionaries,” he said. “The trick is that they will also need to have the executive function necessary to drive a small project to completion.” Game File is a reader-supported publication. To receive new posts and support my reporting, please consider becoming a free or paid subscriber. Subscribe Going big with this Keighley and Cerny may have started Nova and may be the ones primarily backing it right now, but they’re dreaming of something that goes beyond them. “Mark and I may have helped get it started, but one of our measures of success is that Nova grows into something the entire games industry feels a sense of ownership in,” Keighley said. “Our ambition is to build a lasting endowment supported by people and companies across the industry, and an equally broad community of creators willing to give their time and experience to the next generation.” The industry has a lot of knowledge that it can pass to the next generation, Keighley said: “Nova can hopefully become a way to connect that generosity with talented young creators at the moment when it can make the biggest difference.” Cerny, who told me he believes Nova can mature “over the next 10 or 20 years,” sees an opportunity to give generations of game makers momentum. “The industry has changed immeasurably since I started in games in 1982,” he said. “These graduates have talent, training and tools that outclass what we had back in the day by an astonishing amount. But they face a tough road ahead getting traction in the industry, and many could benefit from our support. We want to be there to give it to them.” “There’s a personal side to this, too,” Keighley said. “I don’t have children, and I’ve spent a lot of time thinking about what I can do for future generations. Games have been my entire career. I’ve been incredibly fortunate, and helping someone else build a life in this industry feels like a meaningful way to give back.” Cerny’s oeuvre dates back to Marble Madness and Sonic the Hedgehog 2. He has stood on stage multiple times to reveal the future of PlayStation hardware. He’s been an executive producer for a string of modern PlayStation classics such as The Last Guardian and Marvel’s Spider-Man. Nevertheless, of Nova, he said, “It’s certainly not like anything I’ve done before.” Nova Foundation applications will be due in December and the first wave of fellows will be announced in March 2027. A full list of participating universities and steps students and recent graduates can take to apply to become a Nova Fellow is forthcoming.
Post-World War II economy spurs small-business growth.
This week’s TALE sought out a guest author, Richard “Dick” Coyle, to share the history of one of our long-standing businesses in an article titled “C & C Oil Company: A brief history of 60 years in business.” C & C Oil Company began in 1938 as a simple one-pump service station in Bluffton, Indiana.
OpenAI releases ChatGPT Images 2.5 with 'sharper details' and 'more precise editing'
In April, OpenAI released upgraded image generation technology with ChatGPT Images 2. Five months later, the company is releasing an...
Sega's President Says There's Been an Increase in Fans Who Don't Play Its Games, But That Doesn't Mean They Aren't Gamers
Sega president and COO Shuji Utsumi says the company has experienced an uptick in fans who don’t actually play the games it develops and publishes.
Roundup: Using AI to better integrate virtual modalities into care delivery
Artificial intelligence enhancements in telehealth aim to bolster care continuity while virtual nursing extends bedside care. Also, Zocdoc integrates with Google Gemini to book appointments while Sword Health is set to acquire Headspace's parent company.
Ram Getz & Michael Mortensen Launch i80 Entertainment (EXCLUSIVE)
Ram Getz and Michael Mortensen, partners at GM Management, have launched i80 Entertainment, a new independent production company.
Armor Health Names Regional VP of Client Relations
National correctional healthcare provider Armor Health has appointed Tamara Taylor, RN, CCHP as the company’s first Regional Vice President of Client Relations.
OpenAI Says It Has Cracked One of Math’s ‘Millennium Problems’
The company’s announcement is the most dramatic sign yet that artificial intelligence is fundamentally transforming the field of higher mathematics.
Your Business Is Growing — So Why Aren't You Making More Money? Here's the Revenue Trap Many Founders Fall Into.
More clients, more employees and more revenue can look like success. But if growth isn’t creating more profit, a stronger company and a better life, you may simply be building a bigger job.
Chinese giants Xiaomi, Huawei race to get ahead of Apple’s rumored foldable iPhone
Xiaomi and Huawei launched new foldables ahead of Apple’s event, where the company is rumored to unveil its first foldable iPhone.
Humann Names Dr. Harold Schmitz Science Advisory Chair and Announces Nutrition Research Partnership with the UC Davis Innovation Institute for Food & Health
/PRNewswire/ -- Humann, the Austin-based cardiovascular health supplement company, continued its legacy of engaging with leading academic institutions by...
Apple’s latest acquisition is about technology that sounds futuristic
EU filings revealed today that Apple has acquired a company called Sonera, makers of wearable-centered technology that sounds futuristic.
AZ's R&D chief Barr touts internal 'science success story' after IL-33 antibody's stellar showing in COPD
With a detailed data drop that AstraZeneca’s R&D chief described as an internal “science success story,” the British Big Pharma has secured an FDA priority review for what it believes could become a flagship biologic in chronic obstructive pulmonary disease (COPD). In detailed results from the late-stage Oberon and Titania trials—first teased in March and detailed in full at the European Respiratory Society Congress in Barcelona this week—the drugmaker laid out the extent of its IL-33 inhibitor’s potential to reduce moderate and severe exacerbations in a wide range of COPD patients still struggling with those “lung attacks,” as AstraZeneca’s Sharon Barr, Ph.D., called them, despite using standard-care inhaled therapy. In the headline results, a 300 mg dose of tozorakimab given once every four weeks curbed those moderate and severe exacerbations in the studies’ primary population of former smokers by 29% in the Oberon study and 34% in Titania. In the overall population of both current and former smokers, these reductions were 30% and 29%, respectively, versus placebo and inhaled standard of care. The benefits also extended to clinically meaningful exacerbation reductions in all prespecified patient subgroups and specifically turned up promising signals in patients across a range of blood eosinophil counts, with Barr telling Fierce that “it’s the details that make this even more exciting than the high-level results that we’ve already shared.” In fact, during AZ’s tozorakimab poster presentation at the ERS 2026 Congress this past weekend, attendees were so enamored by the data that event organizers had to encourage people to clear the room and look at the other presentations on offer, Barr said in an interview. “I think it really speaks to the fact that there is a lot of buzz around these data because the entire respiratory community has been so desperate for new therapies for these patients,” she explained. The respiratory disease continues to represent a “staggering unmet medical need,” Barr said, highlighting the COPD exacerbations that the Oberon and Titania studies homed in on, which she added carry a greater mortality risk than a heart attack. “When a patient has a severe exacerbation, only about half of them are still alive within three and a half years,” she pointed out. As for tozorakimab specifically, Barr christened the molecule “an AstraZeneca science success story,” harkening several years back to the point at which researchers began to explore IL-33 as a driver of respiratory disease, and COPD in particular. At the same time, “there was still so much that wasn’t understood,” she admitted, highlighting the insight that IL-33 signals through both ST2 and EGFR through the RAGE pathway, a discovery Barr attributed to AstraZeneca's own scientists. Understanding the need to tackle both pathways in COPD—and aware of competitor candidates in the hopper, including one that bound ST2—the company ultimately had to make some “courageous decisions,” Barr said. These included taking a prior COPD molecule offline and going back to the drawing board to reinvent its potential IL-33 label “to make sure that we had a molecule that could block signaling through both arms of the pathway, through both the reduced form and the oxidized form, knowing that we wouldn’t be first, but striving to be best.” “When we put [tozorakimab] into the clinic, we firmly believed that we had a differentiated molecule, and we saw the other molecules blocking just ST2 or partially blocking IL-33, unable to deliver two positive pivotal studies in COPD,” Barr explained. “We kept marching forward because we believed our molecule was differentiated, and now I think we have the clinical validation that supports that.” Ultimately, AstraZeneca finds itself on much better footing these days when it comes to potential biologic rivals to tozorakimab in COPD. Sanofi and Regeneron’s Dupixent, for instance, is approved to treat COPD exacerbations in patients with high eosinophil counts, but not low ones. Meanwhile, the future has become cloudier for other next-gen IL-33 candidates from Sanofi and Regeneron, as well as Roche, which have suffered trial flops in recent years. One other potential ingredient for AstraZeneca’s success in its duo of studies was that the company was “ambitious in the trial design, willing to look at an all-comers population,” Barr said, “and willing to enroll the most severe patients.” Prior studies for would-be biologics rivals in COPD “avoided enrolling” those patients, she pointed out. She also highlighted the Big Pharma’s painstaking design of exacerbations in its trial, which “gave us a very rigorous readout,” and pointed to “the extra effort and investment” the company put in to understand the effect of mucus plugs in patients. Barr described mucus production as a “key feature in disease diversity,” noting that mucus plugs—obstructing clumps of mucus that block patients’ airways—are associated with worse outcomes in COPD. In its data announcement, AstraZeneca noted that an integrated analysis of Oberon and Titania found tozorakimab “demonstrated a reduction in patients’ mucus plug score,” with the pharma claiming its biologic is the first to deliver such results in a broad COPD population. “So being able to reduce those mucus plugs, we expect, is an important part of driving benefit for patients who are living with COPD,” Barr said. Again touching on the breadth of the study populations, Barr added that tozorakimab “worked across all eosinophil levels in both current and former smokers across all levels of lung function,” which she suggested “really simplifies decision-making for clinicians, and it allows them to offer therapy to the broadest possible patient population.” In the highest patient eosinophil count group, tozorakimab helped chart a 43% reduction in exacerbation risk, which Barr stressed were “unprecedented data.” In the mid-level group, AZ’s drug delivered a 23% reduction and, in the lowest group, a 34% reduction in eosinophils, which Barr said suggests efficacy “in all patient subgroups.” As for AZ’s recent guidance upgrade on the medicine’s sales opportunity, the lift from a $3 billion to $5 billion range to $5 billion plus was informed by multiple factors, Barr said, including the fact that “in 2024, there were multiple competitors, and there aren’t anymore.” Additionally, “we know that this is a massive unmet medical need, and this is a really incredible set of data that we think will be very convincing to the clinical community,” Barr said. Looking ahead to a potential evolution of the COPD treatment landscape, Barr noted that most patients start treatment in the community with an option like a triple therapy, and for them, having an option like AstraZeneca’s inhaler Breztri will remain a “really important part” of that journey. But of the patients uncontrolled on triple therapy, which Barr described as “about half of them today,” just a “small fraction” are currently eligible for biologic therapy, which she emphasized AstraZeneca is working to change. Understanding that COPD is not a “one-size-fits-all” disease, AstraZeneca is also looking at its antibody drug Tezspire for patients with T2-driven disease, and the company continues to think about new mechanisms for tackling COPD through both systemic and inhaled drugs, Barr said.
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