SCROLL NEWS / DISCOVERY
Search headlines
Find the stories shaping the conversation.
Results for " Force " 4,517 found 🔀 AI-powered Shuffle
Negotiations between Cherriots, business leaders paused after months of meetings
Talks between the Salem Area Mass Transit District and representatives from a coalition of six business and real estate groups, and citizens were halted last week, Cherriots said in a press release. The two groups formed a task force to find a compromise after a proposed payroll tax sparked frustration last year. To comment on this story, use the form at the end of the report.
US service member arrested at Capitol after calling for Trump’s impeachment
A US Air Force major was arrested on the steps of the US Capitol on Wednesday after delivering a speech calling for the impeachment and removal of President Donald Trump and Vice President JD Vance.
NY ends public health coverage for 450,000 due to federal funding cuts
Some 450,000 New Yorkers enrolled in the state's Essential Plan lost their health coverage this week after federal funding cuts forced a rollback
http://democrats-energycommerce.house.gov/media/press-releases/republicans-disastrous-health-care-agenda-leaves-millions-americans-without
House Energy and Commerce Committee Ranking Member Frank Pallone Jr., D-N.J., and Senate Finance Committee Ranking Member Ron Wyden, D-Ore., today released their latest report monitoring the devastating impact of Donald Trump and Republicans’ Big Ugly Bill, which has forced millions of Americans to face skyrocketing health care costs and even drop coverage entirely.
House panel explores direct health contracting to lower costs
The House Education and Workforce Subcommittee on Health, Employment, Labor and Pensions July 1 examined whether direct health care contracts between employers and providers could help address rising health care costs.
CVS Health (CVS) Takes A Leading Role In America250 Community Health Events
CVS Health (NYSE:CVS) is partnering with America250 to support community events tied to the United States’ 250th anniversary celebrations. The company plans to help lead community engagement at block parties and public celebrations across major cities. CVS Health intends to use its workforce and local footprint to provide health screenings and volunteer support during these events. CVS Health, with its shares recently trading at $104.81, is adding a fresh public health angle to the...
Securing America’s 250: Law enforcement faces shifting plans and World Cup demands
The day after the White House kicked off celebrations for America’s 250th birthday with a UFC fight on the South Lawn, FBI Director Kash Patel announced that law enforcement had thwarted a plot to attack the event using drones and snipers to target Trump and others.
Elevance pays CMS $342M to assuage concerns of noncompliance and overbilling
The Medicare Advantage insurer said the payout is equal to what a CMS audit stated was the total amount the company was overpaid for patient care services. Despite receiving the cash, the agency has yet to officially withdraw its enforcement action, as the two parties are still negotiating.
Starmer to issue formal apology to mothers and children harmed by historic forced adoption policies
Between 1949 and 1976, an estimated 185,000 babies were taken from unmarried mothers and placed for adoption in England and Wales
Attack on Titan 3 launches this winter, first gameplay
Attack on Titan 3 will launch for PlayStation 5, Xbox Series, Switch 2, and PC via Steam this winter, publisher Koei Tecmo and developer Omega Force announced.
Bayer Group to consolidate U.S. glyphosate business into distinct entity operating as Ruveon
Advances key component of Crop Science division’s Five-Year Framework strategy / Reinforces commitment to delivering trusted Roundup® brands and glyphosate products and services to U.S. customers
Minnesota won’t enforce social media health warning as lawsuit continues
State officials didn’t indicate there would be any delays in enforcement in the days before the law took effect.
Operations workforce powers ORNL’s autonomous science future
Behind every self-driving laboratory at the Department of Energy’s Oak Ridge National Laboratory is a team people most never see. Facilities and Operations workers are building and maintaining the infrastructure that makes autonomous science possible. More than a dozen self-driving labs operate at ORNL, placing the Tennessee national lab among the first research institutions in the world to create this autonomous laboratory model at scale.
Retrofitted Qatari jet takes flight as Air Force One for Trump's N. Dakota trip
It has luxury features like plush carpets, lie-flat seats, wood paneling and a presidential seal on the seat belts
Retrofitted Qatari jet takes flight as Air Force One for Trump's N. Dakota trip
It has luxury features like plush carpets, lie-flat seats, wood paneling and a presidential seal on the seat belts
Trump's new Air Force One: differences, design, cost, photos of inside
Donald Trump flew on the new Air Force One, a luxury jet gifted from Qatar, for the first time. Here's how it compares to the old presidential plane.
Everett water main break forces business closures
Water service along a section of West Marine View Drive was shut off around 1 p.m. Tuesday. The city expects to restore it Wednesday afternoon.
Lionel Richie jokes his 'vitamin pill kicked in' after health scare
Lionel Richie was up and moving in his tour return after a health scare forced him to postpone recent concert dates.
How the Supreme Court became a pivotal force in Trump's immigration agenda
President Donald Trump's administration looked to the Supreme Court to greenlight its sweeping hard-line immigration agenda and, by and large, it got the backing it was looking for with one key exception.
Operations workforce powers ORNL’s autonomous science future
Behind every self-driving laboratory at the Department of Energy’s Oak Ridge National Laboratory is a team most people never see. Facilities and Operations (F&O) workers are building and maintaining the infrastructure that makes autonomous science possible.
Trump ‘excited’ for inaugural flight on Qatari-gifted Air Force One
President Donald Trump shared his excitement for the inaugural flight of the new Air Force One, a luxury jet donated by the government of Qatar, saying the US “couldn’t build a plane like this.”
Microsoft to cut 2.5% of its workforce in yet another round of layoffs
More than 5,000 people will likely lose their jobs pretty soon. It seems like Microsoft continues its series of layoffs, with the last one being in July...
Expansion clock is ticking. Do Big Ten, SEC make final move?
Big Ten and SEC have a shrinking window to expand before new federal legislation could force media rights pooling.
Two siblings joined forces for pest control. Business is booming in CT as bugs bedevil residents
“Locally, ticks are the most dangerous pest for us. Mosquitoes certainly carry diseases, but when people call about nuisance pests, they call with a little more urgency,” Joe Clark said.
Rockstar accused of ignoring pay inequity and mandating crunch
Multiple current Rockstar employees and union members based in the UK claim the Grand Theft Auto maker is failing its workforce.
AI-Driven Restructuring Accelerates Layoffs Across U.S. Technology Sector
Artificial intelligence is rapidly reshaping the U.S. technology industry, with major companies accelerating workforce reductions.
How a new super PAC formed to counter AIPAC is fueling democratic socialists’ wins
American Priorities, which started just six months ago, has quickly emerged as an influential force in House Democratic primaries, spending at least $5.6 million to boost Democrats who are fiercely critical of Israel. It helped democratic socialist Melat Kiros defeat Colorado Rep. Diana DeGette on Tuesday.
The new Pac-12 Conference officially launches with the addition of seven full-time members
July 1, 2026 — Today, seven new full-time member institutions officially join the Pac-12 Conference, including Boise State, Colorado State, Fresno State, Gonzaga, San Diego State, Texas State and Utah State. With the additions, the new Pac-12 features nine full-time members and is set to compete in its first season with the 2026-27 campaign. The league also officially welcomed 12 new affiliate members today across five Olympic sports, including baseball (Dallas Baptist), men’s soccer (Cal Baptist, Cal Poly, UC Riverside, UC San Diego), women’s gymnastics (Southern Utah), women’s swimming (Cal Baptist) and wrestling (Air Force, Northern Colorado, North Dakota State, Northern Illinois, South Dakota State). In addition to official member admissions and the launch of the new Pac-12, and amid celebrations across new member communities, the league also made a series of other announcements related to its basketball tournaments, its official sports sponsorship and championships and a special edition content series in promotion of its first football season.
North Dakota opens wellness equipment funding opportunity for rural hospitals | Health and Human Services North Dakota
From fitness and recovery equipment to mindfulness tools and wellness spaces that help reduce burnout, North Dakota Health and Human Services (HHS) is investing in the health and well-being of rural healthcare workers through a new funding opportunity for rural hospitals.Applications are now open for the Hospital Wellness Equipment funding opportunity through the North Dakota Rural Health Transformation Program (RHTP), providing resources to help rural North Dakota hospitals create healthier workplaces and support the physical, mental and emotional well-being of their workforce.
Microsoft to cut under 2.5% of workforce in latest layoffs, Business Insider reports
Microsoft is planning to cut under 2.5% of its workforce in the latest round of layoffs that could be announced as early as next week, Business Insider reported on Tuesday, citing people familiar with the matter.
Microsoft to cut under 2.5% of workforce in latest layoffs, Business Insider reports
At Yahoo Finance, you get free stock quotes, up-to-date news, portfolio management resources, international market data, social interaction and mortgage rates that help you manage your financial life.
House backs Massie's push to release taxpayer-funded sexual harassment settlement records
Rep. Thomas Massie forced a vote on a resolution requiring public disclosure of taxpayer-funded sexual harassment settlements involving House lawmakers.
Trans Sports Ruling Puts Pressure on States Without Bans
Almost half of states do not prohibit trans girls and women from competing. The Supreme Court ruling doesn’t force them to, but lawmakers and voters could change that.
The End of Independent Federal Agencies Will Change Your Business
For executives, the U.S. Supreme Court’s decision in Slaughter v. Trump will likely lead to less certainty and consistency for the regulated aspects of their businesses, with federal rules and their enforcement increasingly determined by political expediency rather than expert analysis. Specifically, there are five ways in which all U.S. businesses will be affected: regulation will become more informal and less transparent; consistency across administrations will disappear; oversight by Congress and the federal courts will be diminished; expert advice will be devalued; and politically-connected lobbyists will drive decision-making. In this environment, business leaders will need to plan accordingly, honing their ability to shift strategy, perhaps dramatically, after every election—and perhaps even during administrations.
Strengthening Collaboration between Workforce, Health, and Human Services to Meet New Federal Requirements
Human Services Policy Advisors Institute | June 24th, 2026 H.R. 1, or “The One Big Beautiful Bill”, introduced significant changes to work requirements across major health and human services programs. including expanding the populations subject to SNAP time limits, reducing state/territory SNAP waiver flexibility, and creating new work requirements in Medicaid. These changes accelerate the […]
GTA 6 Could Skip 60 FPS Entirely, as Rockstar’s Insane Detail Forces a 30 FPS Lock Even on PS5 Pro
With GTA 6, Rockstar Games is set to raise the bar for what is possible to achieve on PlayStation 5 and Xbox Series X|S much like the studio did with Red Dead Redemption 2, but this is likely coming at a price. Although the highly anticipated next entry in the series is rumored to feature a performance mode running at 60 FPS, it is extremely unlikely this is real, as, according to the tech experts at Digital Foundry, the level of detail shown in the latest footage would make it very difficult to scale everything down to allow for 60 […]
How Trump chose a former Oklahoma state trooper to lead ICE — and handed Markwayne Mullin a win
After an occasionally rocky start in his new post, Homeland Security Secretary Markwayne Mullin won an internal debate when President Donald Trump announced he was nominating Lance Schroyer, a former Oklahoma state trooper, to lead Immigration and Customs Enforcement, five sources familiar with the dynamic told CNN.
Company that made a Steam Machine wrap based on Valve intellectual property without asking forced to take it down
Dbrand's Portal-themed Companion Cube wrap for the Steam Machine won't be seeing the light of day for a very good reason.
Cricket club suffers 'vandalism' for seventh time
A cricket club says it has been forced to pull out of its league after its pitch is ploughed up.
Ariana Grande forced to reschedule shows on her 'Eternal Sunshine' tour
Ariana Grande has rescheduled several shows on her tour. Here's what the pop star had to say about it.
Simon Leis's daughter reflects on her father's legacy, youth mental health advocacy
"We definitely knew there was a love-hate relationship with my father," says Julie Raleigh, on her father, Simon Leis's legacy. Although behind the headlines, Raleigh says that Leis was simply "Dad" to her, remembering him as a man who protected his family in the same way that he tried to keep Hamilton County safe throughout his time in law enforcement.
Israeli strikes kill at least 8 in Gaza, including 2 children, health officials say
While the heaviest fighting has subsided since a ceasefire took hold in October, Israeli forces have carried out near-daily strikes, killing 1,045 Palestinians, including more than 360 women and children, according to health officials in Gaza.
Future OLED Macs and iPads could support a much wider color gamut, per report
As Apple gears up to bring OLED to the Mac, a new TrendForce report looks at the wider color gamut reportedly planned for future MacBook Pro, iPad Pro, and iMac displays.
Dbrand Forced To Pull Steam Machine Companion Cube
Mere after the reveal of the Valve Steam Machine, accessory maker Dbrand announced that it was releasing the "Companion Cube," a Steam Machine accessory that was modelled after the Portal weighted companion cube storage box. Following massive interest in the Companion Cube in the week since its anno...
George Gresham, Health Care Union Powerhouse, Dies at 71
Until he lost an election last year amid accusations of self-enrichment, he was a longtime influential force in Democratic politics in New York.
Unredacted comments from California hospital lawsuits show stunning admissions and a 'forced' McKinsey collaboration
Who controls the Medicaid market, GLP-1 usage and pizza household costs, and more from Health Care Inc.
Heat forces yodelers at annual Swiss festival to sing in fountains
Yodelers at a festival in Basel, Switzerland, turned city fountains into rehearsal spaces during Europe’s June heat wave.
FDLE Relocates Orlando Toxicology Lab to UCF, Strengthening Partnerships and Research
Expansion with the UCF Academic Health Sciences Campus in Lake Nona strengthens the Florida Department of Law Enforcement's forensic opportunities.
TEFCA hits 1 billion as HHS invests $1.28M in network oversight
While marking TEFCA's milestone, ONC announces a new contract to enforce network compliance. Amid ongoing legal battles over alleged network misuses, Health Gorilla CEO Bob Watson emphasizes why federalizing governance is critical to trust.
Supreme Court will weigh Trump-backed Republican push to revive Arizona voting laws
WASHINGTON (AP) — The Supreme Court said Monday it will consider a Republican push to enforce strict Arizona voting laws passed in the swing state after the 2020 election. The high court has allowed some similar rules to take effect temporarily before, including Arizona's proof-of-citizenship requirement for state and local elections and a Virginia purge of voter rolls that the state said was aimed at keeping noncitizens from voting. READ MORE: Supreme Court rejects Trump's
Apple Plans Wider Color Gamut for Future MacBook Pro, iMac, and iPad Pro
Apple plans to adopt OLED panels capable of displaying a much wider range of colors, according to a new report from research firm TrendForce. The new panels would cover 95% of the BT.2020 color standard, which describes a far broader spectrum of colors than the DCI-P3 standard Apple's screens currently target. In practice, that means deeper, more accurate reds, greens, and blues.
KATALIN KARIKÓ
She was met with resistance, got demoted and eventually forced to leave academia – but Katalin Karikó never lost focus, doubling-down on her work to harness mRNA for new vaccines and therapies. Karikó’s Nobel Prize-awarded discovery enabled the development of effective vaccines against COVID-19, offering protection to millions of people.
Kara Swisher took Silicon Valley by force. Now she's eyeing influence in the 2028 campaign
Kara Swisher is expanding her influence from tech journalism to politics
Kara Swisher took Silicon Valley by force. Now she's eyeing influence in the 2028 campaign
Kara Swisher is expanding her influence from tech journalism to politics.
Breaking: T-Mobile To Force Migrate Over 8 Million Customers To More Expensive Plans
Bad news for loyal long-time customers of T-Mobile: prices are about to go up by quite a lot.
WGU’s flexible, skills-first pathways are bridging Detroit’s talent gap
Discover how skills-first education is helping employers address workforce shortages across Southeast Michigan.
🎧 When belief returned: Episode five of new Coventry documentary
The relegation from League One to the bottom tier of English football starts episode five of Back Where We Belong. Under Mark Robins, Coventry City found their identity and stability on the pitch, with fans finding joy in small and shared moments. With Wasps still owning the Ricoh Arena, the Sky Blues were forced to ground-share with Birmingham City at St Andrew's.
Iraqi Officials Arrested in Green Zone Corruption Raid, Deepening Political Tensions
Iraqi security forces arrested several senior political figures in a series of overnight raids inside Baghdad's heavily fortified Green Zone.
ACE WFM Strengthens Workforce System Delivery Approach for Australian Organisations
Melbourne, AUSTRALIA, June 29, 2026 (GLOBE NEWSWIRE) -- ACE WFM, a workforce management consulting provider, has outlined its structured approac...
Trump calls likely DC mayor Janeese Lewis George a 'communist' and vows to block her agenda
D.C. mayoral frontrunner Janeese Lewis George faces clash with President Trump over ICE enforcement, policing, cashless bail and sanctuary city policies.
Rescheduling marijuana would put politics ahead of science
The Drug Enforcement Administration is considering a proposal to move marijuana from Schedule I to Schedule III of the Controlled Substances Act, which would recognize all cannabis products as havi…
Rescheduling marijuana would put politics ahead of science
The Drug Enforcement Administration is considering a proposal to move marijuana from Schedule I to Schedule III of the Controlled Substances Act, which would recognize all cannabis products as havi…
Iraq detains politicians, officials in anti-corruption crackdown
Iraqi security forces arrested politicians and senior officials early on Sunday as part of a broader anti-corruption campaign ordered by Prime Minister Ali al‑Zaidi, a government spokesperson said.
Padres outmatched by Dodgers with nine run inning
SAN DIEGO - Just when things started to look like the San Diego Padres found a resurgence after winning four in-a-row against two of the best teams in league, they run into a mack truck-like force called the Los Angeles Dodgers.
Israeli politicians lash out after Netanyahu announces intention of 'broad national government'
During the press conference, Netanyahu condemned unnamed forces which "want to cause a rift in the people, want to aggravate and deepen the misunderstandings and disagreements and rifts within us."
Trump says he’ll nominate former Oklahoma state trooper as ICE director
President Donald Trump announced Saturday that he will nominate Lance Schroyer, a former Oklahoma state trooper and Marine, to be the next director of Immigration and Customs Enforcement.
You’ve never seen this before: the shocking moment the sound barrier breaks - Futura-Sciences
The XB-1 is a critical stepping stone toward commercial supersonic travel, representing the first civil designed aircraft to break the sound barrier since the Concorde retired. To verify the aircraft’s aerodynamic performance during its supersonic transition, NASA deployed an advanced optical technology called schlieren imaging to make the invisible forces...
Sky Sports: Everton are in the race to sign Serie A midfielder
Everton Transfer News: Mandela Keita Emerges as Midfield TargetEverton continue to search for midfield reinforcements this summer, with Sky Sports reporting that Parma’s Mandela Keita has emerged as...
FISU reinforces its commitment to the World University Sports Movement
On the second day of the meeting, the Executive Committee focused on the upcoming Universiades and the future of the FISU Forum. After a first day concentrating on updating statutes and strategies for a simpler, more innovative and effective future, FISU’s Executive Committee focused on upcoming events on this second and last day of their […]
Could the Vikings eventually be forced to trade Justin Jefferson?
Is there a scenario where the Minnesota Vikings are forced to trade Justin Jefferson?
People complete workforce pilot program designed to address maternal health inequalities
Saturday Pre-orders: Battleforces, Ciaphas Cain, and the Age of Darkness
Check out all of today’s new pre-orders for Warhammer 40,000, Warhammer: The Horus Heresy, and Black Library.
We almost had a smartphone in the 90s. Why did it fail?
In the early 90’s, a company called General Magic began working on a portable device that would allow people to check email, make phone calls, even play games. It was basically a smartphone. But it never caught on.On today’s show, a theory about why this device failed. General Magic had generous investors, world-class talent and creative freedom. But is it possible what they needed was constraints?Support:Planet Money+Read: Our book: Planet Money: A Guide to the Economic Forces That Shape Your Life Our weekly longform Planet Money newsletterOur weekly Indicator round-up newsletterFollow: InstagramTikTokYouTubeFacebookThis episode was hosted by Erika Beras and Emma Peaslee. It was produced by Emma Peaslee with help from Sam Yellowhorse Kesler and James Sneed. It was edited by Marianne McCune and fact-checked by Charlotte Isidore. It was engineered by Jimmy Keeley with help from Cena Loffredo. Alex Goldmark is Planet Money’s executive producer.
Pete Buttigieg was briefly separated from his children after police say he was target of false report
Former Transportation Secretary Pete Buttigieg was the target of an anonymous report that police determined was false and that he says forced him to spend a night away from his four-year-old twins.
MSU Vet Tech program awarded $150k NIFA-USDA grant
Morehead State University's nationally ranked veterinary technology program was recently awarded significant financial support to help it maintain its place as the #1 program of its kind in Kentucky. The National Institute of Food and Agriculture (NIFA), part of the United States Department of Agriculture (USDA), awarded MSU's vet tech program a $150,000 NIFA-USDA grant for equipment to support small and large veterinary technology education and workforce competency at MSU. Learn more about veterinary technology programs at MSU by emailing Staton at a.staton@moreheadstate.edu or calling 606-783-2328. Find out more about MSU's veterinary technology program by calling 606-783-2662.
CBS Sports speculates that Colts’ star could be ‘one of five players to force trade’
Could Colts running back Jonathan Taylor eventually request a trade from Indianapolis?
New York’s primaries signal a new force in US politics
Progressive, Muslim and Arab American candidates are challenging old limits on debate over Israel and Palestine.
Whole Hog Politics: It was voters, not Senate Republicans, who forced Trump’s hand on Iran
The early returns are in, and we can pretty safely say that Americans like the peace with Iran but strongly dislike the war that it ended. The truce is shaky, with hour-by-hour challenges that seem...
Volkswagen reportedly planning to axe 100,000 jobs
Volkswagen, one of the world’s largest automakers, is reportedly planning to axe as many as 100,000 jobs over the next few years, representing 15% of its global workforce.
Whole Hog Politics: It was voters, not Senate Republicans, who forced Trump’s hand on Iran
[Watch Whole Hog Politics live: Join us today at 9 am ET at TheHill.com as Chris Stirewalt and host Bill Sammon break down this week’s political news and answer questions from a live online audienc…
Trump forced to drain the reflecting pool swamp
Jonathan Freedland speaks to Arwa Mahdawi about why this project is proving to be such an embarrassing failure for the president
St. Norbert, FVTC partner to make business degree transfer 'seamless'
St. Norbert and Fox Valley Technical College are joining forces to make getting a bachelor's in business at SNC easier.
The Padres have problems behind the plate
Freddie Fermin’s concussion and struggles at the plate may force the Friars to seek to acquire another catcher.
JD Vance says Nixon’s Watergate scandal would be ‘12-hour news story’ today
Vice-president declares admiration for 37th president and claims Nixon and Trump targeted by ‘deep state’ forces
Sony files WARN notice for layoffs at Bungie in Bellevue
Sony Interactive Entertainment is reducing the workforce at Bungie, with layoffs affecting a significant number of employees.
Making Our Own Luck
We are cross-posting a piece that former NIH official Kris Willis wrote for Macroscience. Kris is now the President and Founder of the Woodley Park Institute, for which I’m a board member. Picking winners or hedging bets? Federal science agencies have long wrestled with the question of how to ensure their billions of dollars of grants and contracts result in maximum benefits for Americans. On the surface, it might seem that a goal-oriented, interventionist style of management would be the best policy: prioritize our most pressing problems and distribute funding accordingly.This top-down strategy creates a unique hazard, though: bad choices can send resources in the wrong direction, resulting in slow progress that impedes the delivery of tangible benefits to citizens. Moreover, if decision makers pursue an applied advance when the underlying scientific principles remain poorly understood, they risk costly failures and a loss of support for the research enterprise at large. Examples include Nixon’s 1971 War on Cancer, undertaken on the premise that a cure could be achieved in less than a decade, the drive to build an operational commercial fusion plant by the mid-1990s, and the National Plan to Address Alzheimer’s Disease, which failed to produce the effective treatments and prevention strategies promised by 2025. The contrasting laissez-faire approach is to hedge your bets. If the path to an advance is impossible to predict, then the wisest choice might be to distribute funding to as widely as possible. The main risk of this strategy is that spreading funding thinly may limit the resources available to the most promising research, resulting in the same negative outcomes as the interventionist approach: limited support for the most promising topics, slow progress, and delayed returns. In reality, at science agencies like the National Science Foundation and National Institutes of Health, program managers navigate between these two extremes, setting some funds aside to target high-priority areas and using the rest to cover the widest possible range of meritorious proposals. This middle path seems like the most rational way to proceed, but it still requires making choices. How much should be set aside for high priority topics? What should those topics be? How should we define merit? Expert opinion can provide a helpful guide, but leading experts can have remarkably different opinions about what matters and what should be prioritized. Moreover, experts and administrators alike can be risk averse, giving an edge to high-profile, well-established concepts. What’s really needed is a data-driven framework to help guide decision-making, one that doesn’t simply repackage prestige or incumbency. Recognizing breakthroughs years in advance Many breakthroughs fail to attract funding or recognition at the earliest stages of development. Katalin Karikó, for example, spent years struggling to win grants for work on mRNA that would eventually win her and Drew Weissman a Nobel Prize. Similar stories can be told about Jim Allison’s groundbreaking studies leading to the development of cancer immunotherapy, Stan Pruisner’s demonstration that prions can self-replicate without DNA, or Robin Warren and Barry Marshall’s proof that Helicobacter pylori, not stress, causes ulcers. Yet at some point, the scientific community recognizes and responds to transformative breakthroughs like these. How does that change happen? And what if science funders could identify the areas that are on the cusp of a breakthrough? Those questions led my collaborators and me to study how scientists responded to past breakthroughs. Based on patterns in that data, we developed a means of predicting future breakthroughs, using biomedicine as a proof of concept. It’s worth taking a moment to describe how our approach works. Briefly, our prediction process begins by grouping the 18 million or so peer-reviewed papers in PubMed, the authoritative database of biomedical research, into roughly 50,000 unique topics. A small subset of these topics are so widely acclaimed as breakthroughs that they have been recognized with a major prize like a Nobel or a Lasker Award. We theorized that studying the development of these outliers over time, especially before they gained acclaim, was the key to identifying future instances of them. After defining topics, we chose 21 representative breakthroughs and asked what they looked like before they won prestigious prizes. To answer that question, we re-ran our topic-mapping algorithm repeatedly, winding back the clock one year each time, stringing together the years to follow the progress of each field as it grew and advanced. We found that in each case, the years leading up to a discovery followed a pattern: a burst of papers on a new, rapidly evolving topic, many of which quickly became influential. These characteristics—the percent of papers that are new, the percentage of papers that are brought in from other topics, and the influence of each individual paper—can all be measured separately for any given topic. Together, they act as a predictive signal that is detectable an average of five years before a transformative discovery is made, and up to thirty years before the discovery receives a major prize. Scanning the current research landscape for topics that display this signal allows us to predict what work will likely produce a future breakthrough. Each year we analyzed includes four or five signals, a number that appears to have remained constant across a twenty year time frame. In their classic work on the sociology of science, Bruno Latour and Steve Woolgar established that the desire to participate in a major discovery is an important motivator for scientists as they consider whether they should take up (or abandon) a research problem. Although further work is needed, the simplest explanation for our results is that this behavior is widespread enough to detect at scale. A foundational advance, or something like it, draws the attention of scientists and causes them to change the direction of their research. They vote with their feet, staking their own reputation and careers by publishing on and citing the new idea. That upswell of interest is the foundation of our breakthrough signal. What kind of research does our model identify as a breakthrough? After building a model based on the patterns in our 21 preselected breakthroughs, we tested it by identifying all early signals of discovery from 1994 through 1997. Of the 18 signals we found in that time period, 17 can be traced forward in time to a breakthrough. Examples include super-resolution fluorescence microscopy (see the image above), the directed evolution of proteins and enzymes (Chemistry Nobel, 2018), and sequencing the human genome (National Medal of Science, 2008). The discovery of the role of leptin signaling in obesity is a particularly interesting case study. Around 1950, scientists noticed the existence of a type of lab mouse that suffered from a unique inherited form of obesity. When given the freedom to choose their own diet, these mice ate more than normal and preferred food that was high in fat. Researchers had few clues as to why the animals overate; early experiments pointed to the existence of a soluble ob factor found circulating in the bloodstream that regulated appetite, but its identity was unknown. In 1994, Jeffrey Friedman and colleagues identified and sequenced the ob gene, noting that the protein it encoded appeared to fit the profile of a circulating factor. A year later, a trio of high-profile publications demonstrated that ob was a hormone that regulated body weight and fat deposition by regulating appetite. One of these was co-authored by Friedman, who christened it leptin from the ancient Greek word for thin. Using our model, the data from 1996 make it clear this advance would become a breakthrough. Scientists had flocked to study the biology of the new hormone, generating the flurry of new papers and citations required to produce a signal. One of these demonstrated that serum leptin concentrations reflected the amount of adipose tissue in the human body, providing clinical validation of the earlier mouse studies. Before the identification of leptin, scientists were unable to point to a specific molecule that controlled appetite and adiposity, so that it was impossible to rule out non-physiological causes of obesity; its characterization fundamentally changed our concept of weight gain. In 2010, Friedman and fellow pioneer Douglas Coleman were awarded a Lasker for the discovery. Our work also identifies breakthroughs in clinical practice and behavioral and social sciences, even though these areas are less likely to draw the attention of major prize committees. One example that falls into this category is the introduction of endovascular aneurysm repair, a minimally invasive surgical procedure for the treatment of abdominal aortic aneurysm, a leading cause of death among Americans over the age of 65. Relative to the previous standard of care, it reduces in-hospital mortality by almost four-fold. In 2017, Timothy Chuter received the American College of Surgeons’ prestigious Jacobsen Innovation award for his multiple refinements to the technique. Another under-recognized breakthrough identified by our model is the development of standardized survey instruments to assess the quality of life for HIV+ patients. The antiretroviral cocktails introduced in the mid-1990s reduced AIDS mortality, but treatment came with serious side effects. The new evaluations showed that patients whose disease progressed had worse physical functioning than Americans with other chronic diseases, while those who were asymptomatic maintained a health-related quality of life on par with the overall US population. This evidence made it possible for patients and activists to argue that even in the absence of a total cure, and in spite of the side effects, alleviation of symptoms was a worthwhile priority for clinicians. My colleagues and I have failed to identify any significant recognition for the physicians and health policy experts who pioneered this advance, although in 2016, researchers called for the World Health Organization to set targets for good health-related quality of life as part of its framework to end the AIDS pandemic. From forecasting to funding How should science funders use our predictions? Any serious discussion of what we should do with this new capability needs to begin with an understanding of its limitations. We can’t (and shouldn’t) invest all of our resources in the small number of topics predicted to produce breakthroughs. Innovative new fields are born from existing ones; they rarely arise de novo. If funders don’t maintain a diverse portfolio, the breakthroughs of tomorrow will have no antecedents. Think of this as eating the seed corn, or killing the goose that lays the golden egg. There are also multiple goals of funding beyond basic scientific discovery, including translating discoveries into clinical practice, developing new technologies, supporting economic development, and training new scientists. The investments needed to accomplish these goals are likely different from those required to support emerging breakthroughs. Finally, we must be aware that we may not capture every instance of a breakthrough. The concept is fuzzy, and not every significant discovery is recognized with a major award. Further, breakthroughs are rare, meaning that our dataset is, by necessity, small. This makes formal estimates of accuracy challenging. Although our overall success rate appears to be high, any one signal may turn out to be a false positive. We found one apparent example: the development of the third generation COX-2 inhibitors, Vioxx and Celebrex, which were much celebrated in the early 2000s as effective but non-addictive pain relievers, meets all the algorithmic criteria of a breakthrough. Five years after it received FDA approval, researchers demonstrated that Vioxx was associated with serious cardiovascular complications, and the manufacturer voluntarily pulled the drug from the market. Celebrex remains available, although like other NSAIDs, it carries an FDA warning for increased cardiovascular risk. Decision makers who were overly focused on the breakthrough potential of this research might have wasted substantial resources nurturing an area that ultimately proved to be a failure—but so would those who relied on expert opinion at the time. That said, the potential benefits of funding the next mRNA vaccine or cancer immunotherapy years earlier than we might have are large. When we can’t assume the outcome of an action, it’s worth conducting an experiment. Can targeted support for areas that are poised to produce a breakthrough increase the return on scientific investment without cannibalizing future advances? With the necessary administrative infrastructure in place, conducting this experiment would be straightforward. First, identify all the breakthrough signals between 2018 and 2023, select half at random, and commit to a decade of investment. For biomedicine, a six year window should yield about 30 topics with the potential to produce a breakthrough. Providing strong support to half of these might be accomplished for $300 million a year. That’s roughly half of the recent annual budget of the NIH Common Fund or around 20% of the fiscal year 2025 budget for ARPA-H. After five years, then again at ten, compare to see which group — the one that was actively managed, or the control — produced more breakthroughs, and on what timescale. Although we used biomedicine as an example, the same experiment could just as well be run for physics, materials science, or any other discipline. Any attempt to undertake such an experiment should keep three points top of mind. First, we can predict the topic of future breakthroughs, but the people and vision for how to move the work forward are still important. In practice, this means success requires active program managers with the expertise to develop the science and the authority to do so, including by recruiting investigators. Second, we would be wise to learn from the failures of past attempts to fund transformative research. High among these are funding modestly repackaged work, confusing the genuinely novel with the merely unfamiliar, and relying too much on incumbent investigators. All of these risks can be mitigated by thoroughly and intelligently integrating high quality data into portfolio management. Finally, we need to have patience. Even with strong funding support, producing a breakthrough takes time. If supporting breakthroughs is the best way to nurture the birth of new fields, we also need to accurately describe and properly manage the other two stages, so that we invest wisely throughout the productive lifetime of ideas and divest once they reach the point of diminishing returns. We would benefit from more study of all of these phases, especially the transition from one to another. More research could answer questions like: When does a breakthrough become an established field? How do the availability of funding, the size and characteristics of the available workforce, and the accumulation of evidence that disagrees with prevailing models affect a field’s decline? Exactly how do old ideas give birth to new ones, and can we speed up the process? The more we understand about the dynamics of scientific progress, the better we can maximize the odds that our curiosity leads to results. I’d call that finding a way to make our own luck.
Scientists measure hidden quantum forces that could power a new generation of pharmaceutical drugs
It's one thing to design a pharmaceutical drug. It's another to know if and why it actually works; not on paper or in a computer model, but inside the chaotic world of living systems, where proteins twist ...
Lionel Richie reportedly hospitalized after medical incident forced concert to end early
Lionel Richie has reportedly been hospitalized after a medical incident on stage forced him to sit down to sing a song on the opening night of his tour with Earth, Wind & Fire.
An Update from PlayStation Studios
Below is an internal email from Hermen Hulst, CEO, Studio Business Group, Sony Interactive Entertainment distributed today to SIE employees. ********************************************************************************** Dear Team, Today I want to share a difficult update regarding Bungie. We have made the decision to reduce Bungie’s workforce, affecting a significant number of employees, including most of the Destiny team and some Marathon team members. There are also reductions across SIE teams that support […]
Scientists measure hidden quantum forces that could power a new generation of pharmaceutical drugs
Researchers invent a laser technique that reveals the hidden forces shaping proteins, advancing a future of precision medicine engineered with quantum precision.
FDA's breakthrough pipeline fills up with generative AI devices
In this edition of STAT Health Tech: FDA drops enforcement against Whoop, more AI devices get FDA 'breakthrough' label, and more.
How should European scientists respond to the US AI kill switch?
Earlier in June, Europe’s worst fears of technological dependence were confirmed when the White House ordered the AI firm Anthropic to stop non-US citizens using its leading models. This kill-switch moment crystalised anxieties in Brussels that the continent, lagging the US on the creation of leading-edge AI models, is now a technological of vassal of Washington. The shock has specific implications for European scientists and universities. Some governments are now worried that with AI being integrated into labs, Donald Trump now has his finger hovering over an off switch for European science. “Having restrictions on this tool, it can have an impact on our own research,” said France’s research minister, Philippe Baptiste, at the VivaTech conference in Paris on June 18.Baptiste, himself a former academic, said that colleagues in mathematics had recently warned him they were now cut off from leading-edge US models, risking their work. “This model is not available anymore now because of the US restriction, and for the first time this had an impact on mathematics,” a field where large language models (LLMs) are making a significant contribution, said Baptiste. So, should European scientists avoid relying on US models in the future? Or would this be a self-harming overreaction? And how is AI being used in science, anyway? What happened?On June 12, it emerged that Washington, citing cybersecurity concerns, had ordered Anthropic to stop non-US citizens using two models: Claude Mythos 5, and Claude Fable 5, a version of Mythos but with guardrails to prevent abuse. Anthropic said Washington’s concerns were overblown. But forced to follow the order, yet with no way to check who was using the models, the company suddenly shut down access for everyone, US citizens included. There’s still no agreement on how to restore broad access. But last week, Bloomberg reported that select US companies, and the US government, still had access to Mythos despite the ban, but the EU’s cybersecurity agency Enisa had been shut out. Class division of researchersIn the longer term, access outside the US should be restored, said Marcel Salathé, co-director of the AI centre at the Federal Polytechnic School of Lausanne (EPFL), because a permanent restriction would be financially ruinous to US AI firms. “Even Trump will eventually budge to economic pressure,” he said.However, US AI firms might end up operating rather like banks, doing due diligence on users of their leading-edge AI models, he went on.European scientists are unlikely to fall foul of such checks, he said. But having a Chinese postgraduate in their lab, or doing a type of research the US disapproved of, could potentially result in access being denied. “It will create a sort of class division of researchers,” he said. More than frontier modelsHowever, successfully deploying AI in science is about far more than just having access to leading LLMs such as Mythos.Instead, many science-specific tools, most famously Alphafold, which predicts protein folding structures, require “far less” computing power to train than frontier models, well within the capabilities of European supercomputers, according to a recent analysis by the Arq Foundation, a Brussel-based AI think tank. Instead, tools such as Alphafold are possible because certain fields, like protein folding, weather prediction or astronomy, have large, clean, standardised datasets that can be used to train predictive models. Rather than compute, “data is the central constraint for AI for science,” the report says. For example, a less powerful physics model trained on CERN’s data “will be more valuable than the best model without certain data,” said Bengüsu Özcan, author of the report. European advantage?Europe could therefore steal a march by using its scientific data and infrastructure to create models US digital giants cannot. “They might actually match or go even beyond what these big [US] companies are doing,” said Özcan.Indeed, some European start-ups hope to create automated testing labs to create the kind of standardised data that could speed up the discovery of new materials. Materials scientists say there’s currently too little data to train models. AI scientistsHowever, even if the bottleneck for AI in science is often data, rather than compute, being at the mercy of the US for LLM access could still become a problem for European scientists. A new class of “AI scientists” based on leading LLMs is also emerging, Özcan’s report says.Unlike domain-specific tools like Alphafold, these try to automate day-to-day scientific work, by providing an overarching tool that coordinates specific models to synthesise existing literature, generate hypotheses or run analysis of data. The problem for Europe, however, is that these tools are sometimes based on US leading models. Google Deepmind’s AI Co-Scientist, for example, is built on Google’s Gemini LLM. Systematic failureThese scientific automation tools are still in their early stages, and still exhibit “systematic failures on scientific tasks,” Özcan’s report says. One of the problems is that the messy, day-to-day process of scientific discovery is largely not documented, meaning LLMs don’t have a good source of data to learn how scientists actually work. Meanwhile, some tasks, such as literature synthesis, don’t typically require access to leading edge models.However, the performance of AI scientific assistants could improve as companies such as Google pour resources into developing them. Rely on US“Unfortunately, for scientific assistants, there is not much we can do right now except rely on US frontier AI,” said Antoine Bosselut, a natural language processing expert based at EPFL. Chinese-built open models, which can run on local computers, lessening the risk of a shutdown, are touted as one alternative to US dependence. There’s also Mistral, once seen as Europe’s main AI hope, but the Paris-based company has seen its recent models fall behind in performance. But the Chinese alternatives are generally not as capable as US frontier AI models, said Bosselut, unless paired with fiddly, custom tools that allows them to act as independent agents. “Most scientists do not have the time,” he said. Don’t jump ship yetAlthough the kill switch moment is seen a warning shot for European scientists, it doesn’t mean labs should abandon US AI tools immediately. “I do not think the right response is simply to abandon US-based models and systems under the banner of sovereignty or independence,” said Mattias Björnmalm, secretary general of the Cesaer university association. “That would be an overreaction.”Related articlesEuropean sovereignty in AI requires ‘ugly trade-offs,’ say experts Robotic lab start-up makes case for €500M EU-funded materials testing facilityAI in science: is it useful? Instead, European researchers need to ask themselves whether they’re becoming dependent on technology that could be turned off in Washington, said Özcan. “They might not see this today, but they should really start asking this question,” she said. European researchers need a plan B, said Salathé. “I would recommend to every researcher, very proactively explore alternatives.”Own toolsIn addition, Björnmalm and others want European research institutions to develop their own scientific AI tools.Instead of signing AI deals with US digital giants, European universities should be using this money to create their own models, which may end up being superior for research, said Sabine Leonelli, an expert on the use of AI in science at the Technical University of Munich. “Universities in Europe seem to be happy to sign commercial contracts with US companies on the assumption [their AI tools] are better,” she said. But US frontier LLMs are typically opaque, and have been developed without independent scientific input, she said. “This is not good enough for science.”Last year, Swiss researchers released Apertus, an LLM designed to be completely transparent, from its development methods to its training data. The idea is that this makes scientific tools built on top of the model far more reproducible than with closed, commercial alternatives.“Europe needs more of this: serious capacity-building that gives researchers, universities and companies credible options,” said Björnmalm.
Around the MHS
This edition of news from around the Military Health System for the week of June 22-26, 2026, includes a vital partnership between Offutt Air Force Base and the American Red Cross, new Uniformed Services University research on stress fractures, and Naval Medical Research Unit EURAFCENT participates in a multinational readiness exercise.
Behind the Curtain: America's great political implosion
Populist forces Trump awakened are devouring the establishment.
Mamdani's success in New York tests Democratic Party's willingness to change
New York City Mayor Zohran Mamdani has stepped into the national spotlight this week as a surging political force within the Democratic Party.
Mamdani's success in New York tests Democratic Party's willingness to change
New York City Mayor Zohran Mamdani has stepped into the national spotlight this week as a surging political force within the Democratic Party.
Mamdani's Success in New York Tests Democratic Party's Willingness to Change
NEW YORK (AP) — New York City Mayor Zohran Mamdani stepped into the national spotlight this week as an ascendant political force within the Democratic Party. Democratic leaders aren't so sure that's a good thing. As progressives cheered across the nation, some of the most powerful Democrats in the ...
Under pressure from Trump, Republican-led Senate reverses course on Iran
The chamber rejected a resolution to force Trump to end the war after he criticized Republicans for undermining his administration’s negotiations.
Senate walks back rebuke of Trump over Iran war
One day after adopting a resolution aimed at removing US military forces from the conflict with Iran, the Senate walked back its rebuke of President Donald Trump’s handling of the war, rejecting an attempt to advance a similar war powers measure.
Senate walks back rebuke of Trump over Iran war
One day after adopting a resolution aimed at removing US military forces from the conflict with Iran, the Senate walked back its rebuke of President Donald Trump’s handling of the war, rejecting an attempt to advance a similar war powers measure.