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An end to the battle between touchscreens and long fingernails is on the horizon
Anybody who has tried to use a smartphone or tablet with long nails knows that there's a learning curve. Rather than effortlessly tapping with a fingertip, you must awkwardly lay the pads of your fingers ...
As mayoral election looms, D.C.’s business class worries about what’s next
A potential leftward shift in the wake of the pandemic and the Trump administration’s cutting of thousands of federal jobs has sparked unease in the city’s business community.
What events are happening in the South Bend area from March 23 to 29?
A variety of events will keep you busy this week. Attend a screening event, catch a concert, attend a lecture or play.
River Cats top Giants in exhibition at Sutter Health Park as fans welcome baseball’s return
"Finally, the drought is over between football and the start of baseball."
Emmanuel Grégoire, a Socialist long involved in local politics, becomes Paris' new mayor
Emmanuel Grégoire has won the Paris mayoral race and takes over from fellow Socialist Anne Hidalgo
Galaxy S27 Ultra may not bring major S Pen reforms
It was rumored that the Galaxy S27 Ultra could bring a major S Pen change, but that doesn't seem to be happening.
Dean for Basic Science Colin Duckett tapped to serve as Boston University Provost
Duckett, executive vice dean for basic and preclinical science, will begin his tenure as chief academic officer at Boston University starting in July.
State lawmakers debate new round of business tax cuts
Rep. Joe Sweeney, R-Salem, and Sen. Donovan Fenton, D-Keene, discussed their support and opposition to House Bill 155, which would reduce the business enterprise tax from 0.55% to 0.50%.
Executive Council seeks greater role in half-billion-dollar rural health initiative
New Hampshire executive councilors are seeking a greater role in a $640 million rural health initiative after initially delaying approval and securing more oversight.
California Politics 360 Full Episode | Sexual abuse allegations against César Chávez
Civil rights leader Dolores Huerta broke her silence, saying she was also sexually abused by Chávez. It led to the birth of two children, a secret she kept for 60 years.
Two new features are officially announced today for the Google Messages app
Google makes it easy to notify members of an RCS group chat while your wife isn't the only reason you're taking out the trash.
24-year-old killed after shooting outside Last Call Sports Bar
24-year-old killed after shooting outside Last Call Sports Bar
Apple’s Worldwide Developers Conference returns the week of June 8
Apple today announced it will host its annual Worldwide Developers Conference (WWDC) online from June 8-12.
A promising fatty liver treatment may raise cancer risk
A surprising new study reveals that blocking a supposedly protective enzyme, Caspase-2, could actually backfire—raising the risk of chronic liver damage and cancer over time. Researchers found that without this enzyme, liver cells grow abnormally large and accumulate genetic damage, leading to inflammation, scarring, and eventually tumors, especially with age. While inhibiting Caspase-2 may offer short-term benefits, such as reducing fatty liver disease, the long-term consequences appear dangerous.
Carrie Anne Fleming, 'Supernatural' and 'iZombie' actress, dies at 51
Carrie Anne Fleming, who appeared on 3 episodes of 'Supernatural' as Bobby's wife Karen, has died. She was 51.
Man who bought $75 worth of Apple products from a stranger in a car park realizes he might be sitting on a small fortune
A tech enthusiast who bought a bunch of used Apple products off a stranger in a car park was left pleasantly surprised by the haul
Apple already has the perfect platform for deploying conversational AI
When Apple initially rolled out Apple Intelligence, the company was pretty openly against the idea of creating a Siri chatbot....
Crews responding to fire burning behind an Upstate business
Multiple fire departments responded to a fire behind the Tractor Supply Co. in Mauldin, SC.
iRacing on Vision Pro bringing 'immersion and fidelity never before seen in sim racing'
iRacing on Apple Vision Pro will bring a “level of immersion and fidelity never before seen in sim racing,” says...
Apple Store Prices for SanDisk SSDs Are Suddenly Astronomical
A 200% price hike is extraordinary.
Israel Thought It Could Spur Rebellion Inside Iran. That Hasn’t Happened.
President Trump’s hopes that an Israeli plan to ignite an internal uprising against Iran’s theocratic government could bring the war to a swift end have so far been dashed.
Chappell Roan pushes back after soccer star Jorginho alleges his daughter was mistreated
Chappell Roan pushes back after a Brazilian soccer player says a guard mistreated his young daughter at a hotel. Jorginho says his 11-year-old recognized Roan at breakfast in São Paulo and got...
Kentucky Gov. Beshear takes jabs at JD Vance in his home state of Ohio
Kentucky Gov. Andy Beshear, speaking in JD Vance’s home state of Ohio on Saturday, tore into the vice president, questioning his Appalachian roots and telling voters they “deserve better.”
Your Thymus and Your Healthspan
Our thymus gland plays a central role in the development or our immune system, specifically for supporting T cell development (how these cells got their name, maturation and differentiation in the thymus) and discriminating between self and foreign, non-self antigen proteins with production of dendritic cells. As we age, our thymus gland shrinks—the process known as involution—with progressive change from spongy to fatty tissue, with loss of functionality. But this process, with respect to timeline and extent, markedly varies from one person to the next. And to make things even more complicated, our thymus gland anatomy and precise location in the chest also is highly variable. So the famous Frank Netter diagrams from the 1960s (such as at left below) don’t capture the remarkable heterogeneity that a random set of 12 chest CT scans (below at right). What I consider as 2 landmark papers in Nature this week (here and here) used AI to quantify health of the thymus in 2 large cohorts, and then correlate the metric to a broad array of health outcomes. In this edition of Ground Truths, I’m going to cover three questions: (1) How was thymus health determined by AI?; (2) How is thymus health linked to key clinical outcomes? and (3) Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? Subscribe 1. How was thymus health determined by AI? This was accomplished by extensive work developing and validating an AI pipeline for 2 stages, the first for localization and segmentation of the thymus bed, and the second to quantify a digital marker, termed the thymic health score. There’s a lot to this algorithmic development, so I won’t go into all the details, but just provide a rudimentary outline of what was done. The 1st stage used supervised learning with 2 radiologists reviewing 2,461 chest CT scans. That work trained a 3D U-Net model to automatically identify the thymic bed’s 3D cropped region using center of mass coordinates, which reached 99.8% accuracy. The 2nd stage used a foundation model that was pre-trained with SwAV (which stands for Swapping Assignment between multiple Views), a self-supervised model, that generated a high-dimensional thymus representation of 4,096 features. That compares to the radiology reductionist and subjective scoring of 0 to 3 where 0 means the thymus is fully degenerated and fatty, and 3 is considered dense, intact glandular soft tissue. Notably, the self-supervised learning (SSL) performance was superior to supervised (AUC ~0.75 vs 0.55, respectively) reflecting the shallowness of the 0-3 classifier vs SSL’s holistic, self-taught AI. The thymic health score ranged from 0 to 100, with the highest number indexed to fully preserved thymic health. The algorithmic work extended to explainability with both Shapely value distribution, meaning the model was holistic not relying on any “magic” pixel, and occlusion sensitivity, demonstrating the model’s performance was not affected by ribs, sternum, lung tissue, but rather focused on the thymic bed directly. Below are a few saliency maps from the occlusion sensitivity that indicate the thymic bed focus, not affected by neighboring structures, using the jet color scale. Now the AI was ready for processing ~25,000 CT scans, each over 30 MB files, from the 2 large participant cohorts to provide a thymic health score, it did so in less than 14 hours, which is less than 2 seconds per scan! Share 2. How is thymus health linked to key clinical outcomes? The two cohorts were the National Lung Screening Trial, NLST (N=25,031) and the Framingham Heart Study, FHS (N=2,581) each with baseline demographics and long term follow up of >12 years for health outcomes. From the NSLT, you can see below that increased age and body-mass index were correlated to reduced thymic health. And, overall, men had reduced thymic health scores compared with women. There are a lot of graphs in the paper for outcomes, for both the NLST and FHS cohorts. To simplify the major outcomes, below is a composite Figure with striking reduction of all-cause mortality and for the different causes of death. The results were consistent between the 2 cohorts. For example, the cardiovascular mortality hazard ratio average was 0.57 in NLST and 0.38 in FHS (weighted to be 0.53 for the aggregate). The reduction of mortality also extended to digestive diseases and pulmonary disease (data not shown below). Lung cancer incidence was reduced by 36% for high vs low thymic health (Figure below, with a panel -incidence and b panel-mortality, adjusted for age, sex, BMI, smoking status). Notably, there was a smoker’s paradox: lower incidence and improved survival for lung cancer in smokers who had a high thymus health score. Smoking was associated with lower thymic scores whereas alcohol was not. Higher thymic health was linked to higher HDL cholesterol, lower triglycerides, lower fasting blood glucose, and lower systolic and diastolic blood pressure. Inflammation biomarkers, such as C-reactive protein and interleukin-6, were elevated in the people with lower thymic health scores. In their second paper, the same team looked at the relationship between thymic score and outcomes for 3,476 patients receiving cancer immunotherapy. The non-small cell lung cancer progression-free survival was reduced in patients with low thymic health score. A parallel relationship for survival was seen for other types of cancer including melanoma, breast, and kidney with a 44% lower risk among high thymic scores (Figure). A similar pattern was seen with different immune checkpoint inhibitors. The thymus health score outperformed programmed death ligand-1 (PD-L1)and tumor mutation burden (TMB) assay of the tumor and was an independent prognostic marker of progression-free survival. In this dataset, a direct connect with thymus score and adaptive immune function was noted with a correlation before cancer treatment for both T-cell diversity and thymus T-cell production (a metric known as T cell receptor excision circles). Thymus Removal Study There is a highly relevant citation about thymus function before moving onto ways to rejuvenate it. In 2023, a very important study of thymus removal during cardiothoracic surgery was published, with 1146 patients undergoing thymus removal vs 1146 matched controls (mean age 55 years). The adverse outcomes for thymus removal were striking, with a 2.9 higher risk of all-cause mortality and doubling of cancer incidence, 1.5 fold increase in cancer mortality, and 1.5-fold increase in autoimmune diseases. The immune function showed marked compromise after thymus removal, as reflected by CD4+ and CD8+ T cells (Figure below) Share Ground Truths 3. Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? In recent months we’ve learned a lot about the process of thymus involution and the pathways by which this may be modulated. Thymus involution is primarily due to loss to thymus epithelial cells (TECs) and there are 2 subtypes with different functions: the cortical, responsible for positive selection of T cells, and the medullary, for negative selection. When adipose tissue infiltrates the thymus, thymic adipocytes are pro-inflammatory, knocking out T-cell output. Likewise, systemic inflammation, or “inflammaging,” from smoking, obesity, and chronic stress promote thymic adipocytes. Now, from preclinical studies, we know about key pathways that account for these processes. Historically, back in 2014, FOXN1 was recognized as a single master transcription factor essential for TEC function, with studies in mice with forced FOXN1 upregulation leading to thymus regeneration. That laid the foundation for potential regrowth of quiescent thymus cells. It took awhile to find pathways to accomplish this goal and to even refute its role as the master regulator. The Liver-Thymus Axis Feng Zhang and his team recently showed that injection of an mRNA vaccine to the liver encoding DLL1, IL-7 and FLT3-L in combination, factors known to support thymopoiesis (Figure), successfully enhanced immune function in aged mice. However, the effect was transient. The FGF21 Story Two reports in 2025 addressed the thymus gland’s production of FGF21, a growth factor (fibroblast growth factor 21) and its control of thymus involution. This growth factor is also produced by the liver, but it doesn’t have impact on the thymus in aged rodent models. In contrast, The liver’s hepatocyte growth factor (HGF) has been shown to reverse senescent TEC structural changes. Growth hormone stimulates production of insulin growth factor-1 (IGF-1) in the liver and the thymus. Two small studies in human participants (TRIIM, for Thymus Regeneration, Immunorestoration, and Insulin Mitigation) of 6 and 50 people, respectively, treated with combined human growth hormone, metformin and DHEA, suggested the potential of slowing epigenetic aging and improving thymus mass and function. But the combination of drugs, small sample, and lack of controls make conclusions murky. Increased thymus FGF21 led to increased CD8 T cells in old mice and extended healthspan and improved physical performance. Building on the previous FOXN1 data, ablation of β-klotho, the obligatory co-receptor for FOXN1, accelerated thymic aging. The benefit to FGF21 was confirmed in a companion paper using an FGF21 knock-in mouse model showing thymus enlargement and increased TECs throughout the lifespan. (schematic Figure below). The accompanying editorial for these 2 papers speculated: “The proposed link between age-associated thymus involution and organismal aging is intriguing, and suggests we might seek to achieve systemic rejuvenation by counteracting thymic involution.” Other Factors Lessons from the Axolotl (Mexican Salamander) In an elegant set of experiments of the axolotl (Figure), known for its complete thymus regeneration after total surgical removal, mediators were identified. Surprisingly FOXN1 was dispensable. But midkine, a growth factor, appeared to be the driver, the initiator of thymus cell growth, survival, and repair. Other components that contributed were Postn+ (periostin-expressing mesenchymal niches) and Ccl19, a chemokine protein from the bloodstream. RANK and RANKL RANK (receptor activator of nuclear factor κB its ligand (RANKL) have been considered key regulators of medullary TECs. In a study of both aged mice and human thymus cell cultures, their key role was confirmed, with multiple benefits of resorting TEC function, recruitment of progenitor cells, and T cell development. Subscribe Summing Up This body of work strongly supports the health of the thymus gland as a critical regulator of human healthspan, not just a correlate or link. The new landmark studies are reinforced by the regenerative biology experimental models that have shown, via an array of mediators, that healthspan of aged mice is at least in part dependent on thymus gland function and its critical role for maintaining adaptive immunity. It sure seems that we’d be better off having an immune reservoir of naive T cells instead of a profile in older adults of exhausted, low quality, memory T cells, with a senescent phenotype. It is striking that we ignored the importance of the thymus gland for many decades. A wake-up call was the results of the thymectomy matched control study reviewed here, with the opposite of high thymic health score improved health outcomes. The convergence of AI and healthspan here is notable. The exceptional and laborious work for developing and validating (no less explaining) the AI to quantify thymus health set the foundation for probing the connect the major health outcomes in two cohorts with extensive follow-up. We’ve never had a way to meaningfully quantify the thymus gland before, so this represents important leverage of supervised, self-supervised, and transformer models. The study wouldn’t have been possible without AI. And it begs the question as to whether there are ways we can maintain our thymus at a high health score. But it’s not so simple to rejuvenate our thymus. There are multiple risks including the induction of autoimmunity, increasing the risk of cancer, and inducing a pro-inflammatory state. For example, factors that increase TEC proliferation could compromise the medulllary negative selection process and leak out auto-reactive (self-attacking) T cells. Thymic cells could be induced to proliferate, but we know, for example, that growth hormone and IGF-1 are associated with an increase risk of cancer. If thymus rejuvenation doesn’t clear out the accumulated senescent cells in older adults, then inflammation within the gland could block the production of TECs. Keeping these risks in mind, we now have identified many ways to keep our thymus healthy as we age that undoubtedly will be tested in clinical trials going forward. Ultimately, the benefit-to-risk tradeoffs will be defined. In the meantime, we have desperately needed an immunome. As I’ve stressed in multiple prior Ground Truths, we have no test in the clinic to assess a patient’s immune status! It was very encouraging for me to get an email from Hugo Aerts, the senior author of the landmark papers in the days after they were published: “I also wanted to say that your Substack on “Why We Need an Immunome” was inspiring for this work. We found it a very compelling perspective and greatly enjoyed reading it.” Just having an assessment of a person’s immune status via a chest CT scan, with millions of these performed per year, might help in guiding the right immunotherapy for cancer (e.g. more intensive, combinations for those with low thymic health scores) and help define people who are increased risk for age-related diseases of cancer, cardiovascular, and neurodegenerative. The main theme of Super Agers is that we now have many layers of data (genetics, proteins, biomarkers, organ clocks that can be integrated via multimodal AI) for us to define a person’s specific risk decades before one of these age-related diseases leads to symptoms, enabling prevention. From the new studies this week, we can add thymus health score as yet another way to understand a person’s risk, a window into their adaptive immune system and healthspan. And perhaps someday we will be able to safely rejuvenate the thymus, or maintain its health through one’s life, and use the thymus health score to monitor. NB: I wrote this post (No A.I.) A Quick Poll Loading... ********************************************************************* Thanks to Ground Truths subscribers (now > 200,000) from every US state and 212 countries. Your subscription to these free essays and podcasts makes my work in putting them together worthwhile. Please join! If you found this interesting PLEASE share it! Share Ground Truths Paid subscriptions are voluntary and all proceeds from them go to support Scripps Research. They do allow for posting comments and questions, which I do my best to respond to. Please don’t hesitate to post comments and give me feedback. Let me know topics that you would like to see covered. Leave a comment Many thanks to those who have contributed—they have greatly helped fund our summer internship programs for the past two years. It enabled us to accept and support 47 summer interns in 2025! We aim to accept even more of the several thousand who will apply for summer 2026.
What’s happening in Vegas arts entertainment this spring
Festivals, concerts, sporting events and more: Make plans with our entertainment calendar.
Chappell Roan reacts to claims her security made Jude Law's 11-year-old daughter cry: 'I do not hate children'
Chappell Roan has responded to claims that her security guard made Jude Law's 11-year-old daughter cry after she got excited when she spotted the singer in a hotel: 'I do not hate children— that is crazy.'
Bucket hats and home run chains: Getting decked out for baseball season at Poor Boys Sports
From shirts featuring new players to hats in every color, Poor Boys Sports has all your Orioles merch needs for Opening Day.
Kennedy’s latest MAHA-approved plan could supercharge peptide boom
He indicated that the FDA will soon widen access to the small proteins, which biohackers tout as therapies for a range of ills
Apple’s busy March continues with three notable arrivals this week
Apple has had a jam-packed March so far after launching seven new products and surprisingly announcing an eighth. Looking ahead,...
Tom Steyer explains why he should be California's next governor
Tom Steyer sat down for an interview with California Politics 360 for a wide-ranging conversation on his run to be the state's next governor.
Assemblywoman Alexandra Macedo says César Chávez allegations are "just the tip of the iceberg"
California lawmakers this upcoming week are set to move quickly to rename César Chávez Day to Farmworkers Day ahead of the holiday that takes place every year on March 31.
Crimson Desert Dev Breaks Silence Admitting AI Art Was Used
Developers Pearl Abyss apologize for their inclusion and promises to replace its slop with new art.
Apple iPhone Fold Might Have A Sun Glare Problem
Given the already high reflectance of iPhone displays, Apple's use of a CoE filter on the iPhone Fold can lead to a sun glare problem.
VoidStealer malware steals Chrome master key via debugger trick
An information stealer called VoidStealer uses a new approach to bypass Chrome's Application-Bound Encryption (ABE) and extract the master key for decrypting sensitive data stored in the browser.
Long Lost 'Mystery Science Theater 3000' Episode Finally Found
Thanks to a garage sale, the 'Star Force' episode from the earliest days of 'Mystery Science Theater 3000' is online for all to see.
iPad 12 With A18 Chip for Apple Intelligence is 'Still Coming This Year'
Apple has updated a wide range of products and accessories this month, but there is still no entry-level iPad 12 with Apple Intelligence support. Fortunately, Bloomberg's Mark Gurman today said an iPad with an A18 chip for Apple Intelligence is "ready to go" and "still coming this year". An earlier report from Macworld claimed that the iPad 12 will actually have an A19 chip.
New Apple TV and HomePod Mini Remain 'Ready' to Launch
Apple has unveiled nine new products this month, but the wait continues for the next-generation Apple TV 4K and HomePod mini models. In his Power On newsletter today, Bloomberg's Mark Gurman said new versions of the Apple TV and HomePod mini have been "ready" since last year, but he reiterated that Apple has held off on releasing them until the more personalized version of Siri and other Apple Intelligence upgrades are released later this year.
Urgent Apple warning: Update your iPhone, iPad now
Roughly 25% of all iPhones are operating a version of iOS 18.
How iNaturalist app users have fun while aiding science
Apple Has Released More Than 10 Products and Accessories This Month
It has been a busy March for Apple, which has unveiled more than 10 products and accessories this month. However, aside from the all-new MacBook Neo and Studio Display XDR, the devices received faster chips or new colors and little else.
Report: New iPad with A18 chip still on track to launch in first half of 2026
As part of Apple’s week of product announcements earlier this month, many were hoping to see an update to Apple’s...
Oscar-Winning Alumnus Returns to Pasadena’s ArtCenter for Entertainment Design Expo
One week after winning the Academy Award for Best Animated Feature, KPop Demon Hunters co-director Chris Appelhans returns today to ArtCenter College of Design, the Pasadena campus where he studied illustration, for the college’s third annual Entertainment Design Expo. The expo, known as ENTX, opens the Hillside Campus to the public for a full day of gallery exhibitions, game playtesting, animation screenings and interactive experiences featuring work from more than 200 ArtCenter students and alumni. General admission is free with advance registration. Two industry panels — including Appelhans’s talk — require $15 tickets. Appelhans, who graduated from ArtCenter with a bachelor of fine arts in 2002, co-directed KPop Demon Hunters with Maggie Kang. The animated film, produced by Sony Pictures Animation and released on Netflix, became the streaming platform’s most-watched film in history, according to Netflix, and swept awards season with wins at the Golden Globes, the Annie Awards and the Grammys before taking the Oscar on March 15. His talk and audience Q&A is scheduled from noon to 1 p.m. in the Ahmanson Auditorium. Doors open at 11:30 a.m. The film’s ArtCenter ties extend beyond its co-director. Art director Angela Sung, cinematographer Gary H. Lee, visual development artist Celine Kim and painter Simon Baek are all ArtCenter graduates who worked on the production, according to the college. The free portions of ENTX include a concept design showcase, a production design gallery, a model gallery, a stop motion studio preview, an alumni gallery and a KPop Demon Hunters fan art gallery. Visitors can also playtest games designed by ArtCenter students. An Animation Shorts Showcase runs from 2 to 3 p.m. and includes “Boy, I’m Scared,” a capstone short by ArtCenter graduate Lindsey Tenaglia that was named a semifinalist for the 2025 Student Academy Awards in the animation category. Also screening
Scientists discover surprising brain trigger behind high blood pressure
Scientists have uncovered a surprising brain-based trigger for high blood pressure, tracing it to a small region in the brainstem that normally controls breathing. This area, which kicks in during forceful exhalations like coughing, laughing, or exercise, also appears to activate nerves that tighten blood vessels—raising blood pressure. When researchers switched off this region in experiments, blood pressure dropped back to normal, suggesting it plays a direct role in hypertension.
Scientists Startled by What Happens When They Point Hubble at Comet
An extraordinary coincidence occurred when astronomers pointed the Hubble Space Telescope at a wayward comet.
Inflatable homes on the Moon? Scientists reveal how humans could live there sooner than expected - Futura-Sciences
How could humans live on the Moon? Although the Artemis program has taken a more cautious approach following recent delays, the goal remains the same: send astronauts back to the lunar surface. Doing so will require systems that allow crews to stay there for several days, or even several weeks....
4 Things You Never Knew Your PS5 Could Do
The PlayStation 5 lets users create custom button mapping, play from a PC and Mac, use motion control to aim, and amplify sounds with headphones.
Electron's Investment Into Good Wayland Support
For years Electron apps were notorious for continuing to depend upon X11/XWayland and not jive well with the modern Wayland experience on modern Linux desktops
The case against the Senate filibuster no Republican can make
How to put Congress, not the president, in the U.S. politics driver’s seat: End the 60-vote tradition.
Four truths about covid that have become clouded over time
In the early days, the virus posed a graver threat to people and the health care system, Trump embraced lockdowns he now blasts, and the benefits of vaccines were oversold.
White House navigates vaccine politics, midterm risks in CDC director search
The Trump administration faces complicated political dynamics as it seeks someone to helm the key public health agency suffering a prolonged leadership vacuum.
White House navigates vaccine politics, midterm risks in CDC director search
The Trump administration faces complicated political dynamics as it seeks someone to helm the key public health agency suffering a prolonged leadership vacuum.
Federal employee retired, works at TJ Maxx; feels happy, less stress
Karime Masson thought she'd keep working for the Social Security Administration until she was at least 62. But after a tough 2025, she retired early.
Prior authorization can delay needed health care. A new 'Gold Card' targets that bottleneck.
Getting approval for a medical procedure scan or medicine has become a frustrating hurdle in health care as insurers try to ensure that every test is appropriate...
Politics: Iowa Senate majority leader outlines plans for coming weeks
Second funnel week concluded in the Iowa Legislature, meaning that lawmakers’ focus can return to funding, appropriations and other types of specific bills that don’t respond to the Legislature’s self-imposed
Things to do in Cincinnati this week, March 23-29
If you're looking for the best events happening in Cincinnati, you're at the right place. Find your next concert, game, festival or family event.
As War Disrupts India’s Gulf Ties, Economy Faces ‘New Broadside’
Generations of Indian workers and businesses have turned the Arab side of the Gulf into a vital appendage of their own country.
Mapping a career in electron microscopy
Nature Reviews Chemistry - Ahead of his 60th birthday, Paul A. Midgley, Professor of Materials Science at the University of Cambridge, discussed his life in science.
79 Brilliant Memes That Brought Science And Humor Together
Let’s be honest—complex physics theories and mind-bending math problems can leave most of us staring blankly, wondering what just happened. But one thing most of us can understand is a good meme about them. Somehow, even the most complicated subjects become instantly relatable when they’re turned into a clever joke. And that’s exactly what we’ve got for you today, pandas. We’ve rounded up a bunch of science and math memes that take these “serious” subjects and give them a fun twist. You might no
Milwaukee stair climb raises awareness for lung health and firefighters
The American Lung Association hosted its 18th annual stair climb in Milwaukee, where participants, including firefighters, climbed 30 stories to raise funds and awareness for lung health.
Trump continues to target Robert Mueller after his death
Mueller, who led the Russia investigation and the bureau after 9/11, remained a target of Trump years after his probe of possible election interference.
Halide co-founder is suing former partner for bringing source code to Apple
Startup drama.
Sony PlayStation Network down: PS5 users report widespread server issues; 'please fix it'
Sony PlayStation Network appeared to be down for thousands on Saturday as many flocked to social media to voice their complaints. | World News
Senate rejects Trump-backed measure to ban trans athletes in female sports
The chamber considered adding the measure to a far-reaching voting bill supported by the Republican president.
Mainieri out as South Carolina's baseball coach in 2nd season
Paul Mainieri is out as South Carolina's baseball coach midway through his second season after he couldn't approach the level of success he had produced at LSU.
Speedrunner Discovers Massive Glitch In Pokémon Switch Port
Swiss runner iamClemi accidentally hit the L button while choosing a starter, but something was off
Robert Mueller, ex-FBI director at center of political tempest, dies at 81
After building a reputation for quiet rectitude, he became a political target as special counsel investigating Russian interference in the 2016 election.
Queens small businesses push for stronger safety measures after attempted robberies
QUEENS, N.Y. (PIX11) — Business owners in Queens are calling for stronger public safety measures after an attempted break-in at one of Woodhaven’s most well-known landmarks. The incident happened earl...
Crimson Desert Hears Your Complaints And Will Fix The Controls
Pearl Abyss says its listening to Crimson Desert players' complaints about the complicated controls and will patch in new options ASAP.
Apple M5 MacBook Pro and Air Review: When the Neo Isn’t Enough
Apple’s new laptops and high-end display fit the bill for the company’s most demanding customers.
Super PAC spending passes $200M, with some groups hiding their cause
Groups that include pro-Israel organizations obscured their spending in some midterm races to try to defeat candidates that oppose their cause.
ChatGPT Took a Science Exam Designed by College Professors and Scored a Low D, and That Should Worry You
Confident. Clear. But a new study suggests ChatGPT's polished tone might be masking something far more troubling about how it actually reasons.
California settles with El Monte schools over misconduct complaints
The El Monte Union High School District must appoint a compliance coordinator and roll out an electronic sexual misconduct complaint system.
Refund checks coming for former Boston Sports Club members, AG says
Former members of Boston Sports Clubs in Massachusetts may be eligible for a refund if they were wrongfully charged by the company during the COVID-19 pandemic.
iPhone 18 Pro camera may come with pro software, Apple considered buying Halide
Two months ago, Halide cofounder and designer Sebastiaan de With made a surprise announcement that he was joining Apple’s design...
Apple Wanted to Buy Halide to Boost iPhone 18 Pro's Camera App—Now There's a Lawsuit
Apple's plans to enhance the iPhone 18 Pro's Camera app led it to consider acquiring Halide, but the talks ultimately collapsed and were followed by a fierce legal dispute between the startup's co-founders, according to The Information reports. In the summer of 2025, Apple reportedly held discussions to acquire Lux Optics, the developer behind the popular iPhone camera apps Halide, Kino, and Spectre.
The surprising ways menopause can affect your mouth — and what you can do about it
Apple TV Is Now Almost 20 Years Old
The Apple TV is now almost two decades old amid rumors of the announcement of a new model. Today marks 19 years Apple launched the original Apple TV. Apple CEO Steve Jobs unveiled the Apple TV at Macworld Expo in January 2007 alongside the original iPhone, but it didn't launch until March. The Apple TV was initially previewed as the "iTV". The device allowed users to wirelessly stream movies, TV shows, music, and photos from their Mac or PC directly to their TV.
Ex-Dolphins WR Jaylen Waddle on trade: 'It’s part of the business'
"You never know for sure and what could happen," Jaylen Waddle said of NFL trades. "It’s part of the business."
Tom Kean Jr.'s political roots date to 1776. Is that enough to protect the Republican's House seat?
Tom Kean Jr.’s bid for a third term representing New Jersey’s 7th Congressional District offers a window into the larger battle for control of the narrowly divided House
Engadget review recap: Lots of Apple devices, Galaxy S26, Dell XPS 16 and more
A roundup of the latest reviews from Engadget.
The new MacBook Pro is still fast as hell
How big of an upgrade is it for M1 Pro / M1 Max owners?
The insular bubble of caucuses and assemblies
Nearly 30 years ago, then-Federal Reserve Chairman Alan Greenspan coined the term “irrational exuberance” to describe the overheated stock market. That descriptive phrase could also apply to much of the political realm. The hype in politics often grossly exceeds the reality on the ground. In that vein, let’s focus on Colorado’s precinct caucuses held earlier […]
Trump and the politics of death
COVID, gun violence and Iran reveal a governing instinct based on authoritarian violence disorder
Inside Fidji Simo's quest to make OpenAI profitable
Nearly 8 months into her job as OpenAI's CEO of Applications, Fidji Simo must start minting money while convincing staffers the mission hasn't changed.
Congress could be headed for a tipping point, irreversible decline
After nearly two decades covering Capitol Hill, a reflection on how bad things are.
Combating youth suicide tilts increasingly toward early intervention
A suicidal child or teenager may never talk of taking their life. Parents, peers and teachers might not even know they’re living with mental illness. Despite younger generations showing greater openness to discussing mental health struggles, fears of punishment or social exclusion remain, experts say. Even at medical appointments, minors
🗞️Today's headlines: Joan García, academy talent and much more
The call from Luis de la Fuente to Barça’s goalkeeper is one of the top stories of the day on this football-filled Saturday.A great weekend is approaching ahead of an international break, where the...
At age 41, a Westmoreland mom of 3 is diagnosed with a cancer that's rising in younger populations
When Misty Ament felt sharp pain in her right side last August, the 41-year-old assumed she was dealing with appendicitis. Instead, doctors discovered...
Sacramento businesses recover after string of burglaries; 1 suspect arrested
Sacramento police have arrested a man believed to be connected to 11 burglaries affecting local businesses, as authorities work to prevent further incidents.
Israel strikes Hezbollah's civilian as well as military wings in an attempt to crush the group
An Israeli strike has hit a Hezbollah-run health center in southern Lebanon and killed 12 medical workers, as Israel widens its campaign beyond fighters
One arrested, another cited in shoplifting incident at business on East Avenue in Chico
CHICO, Calif. - A Paradise man was arrested and a Forbestown woman was cited by Chico Police in connection to a shoplifting incident at a business in Chico.The Chico Police Department says that at around 12:30 p.m. on Wednesday, March 18, a loss prevention employee observed two suspects stealing several items from a retail business on the 700 block of East Avenue in Chico.Upon exiting the building, the two suspects, a man and a woman, were contacted by the loss prevention employee regarding the stolen items. The employee was able to persuade both suspects to return to the store and hand over the items they had stolen.Authorities say the business expressed their desire to press charges against the suspects and contacted Chico Police to report the crime.Officers reviewed video surveillance that confirmed the employee's account of what happened. Officers then made arraignment for both suspects to turn themselves in the following day.When the suspects, identified as 51-year-old Jamie Leal of Forbestown and 62-year-old Melvin Royal of Paradise, arrived the next day to turn themselves in, authorities say both admitted to their involvement in the incident and elected to write handwritten apology letters to the business.Leal was cited by Chico Police on a misdemeanor charge of shoplifting.Royal was taken into custody and transported to the Butte County Jail, where he was booked on the following charges:Shoplifting with 2+ priors (felony)Shoplifting (misdemeanor) googletag.cmd.push(function() { googletag.display('ad-1514992'); });
Devils' win streak snapped with 2-1 loss to Capitals
Logan Thompson made 30 saves, losing his shutout bid with just 43 seconds remaining, and the Washington Capitals beat the New Jersey Devils 2-1 on Friday night.
Short-Term Cuts, Long-Term Costs: Investing in Health Care for All Californians
Providing health care for all Californians improves health, strengthens communities, and prevents higher long-term costs.
Downtown Chico business owner voices concerns over street closures for events
A DOWNTOWN CHICO MERCHANT IS EXPRESSING CONCERN OVER THE IMPACT OF STREET CLOSURES FOR EVENTS -- ON THEIR BUSINESS. ACTION NEWS NOW REPORTER BELLA BARBOSA REPORTS FROM DOWNTOWN CHICO { "@context": "https://schema.org", "@type": "VideoObject", "name": "Downtown Road Closure Dilemma", "description": "A DOWNTOWN CHICO MERCHANT IS EXPRESSING CONCERN OVER THE IMPACT OF STREET CLOSURES FOR EVENTS -- ON THEIR BUSINESS. ACTION NEWS NOW REPORTER BELLA BARBOSA REPORTS FROM DOWNTOWN CHICO", "thumbnailUrl": "https://bloximages.newyork1.vip.townnews.com/actionnewsnow.com/content/tncms/assets/v3/editorial/c/47/c47e26d6-03c3-5f35-bf49-37925ab603d7/69bdedc4eb57d.image.jpg", "uploadDate": "2026-03-20T17:45:00-07:00", "contentUrl": "https://cdn.field59.com/KHSL/1774053903-6e1ef36dd09fbebf020833aee86b60da3b3cca3f_fl9-720p.mp4" } CHICO, Calif. - A downtown Chico business owner is voicing concerns about the impact of street closures for events on local shops. Leann Powell, owner of The Peddler’s Closet, expressed concern about events closing down streets downtown and bringing in food trucks and other shops’ products that directly compete with the brick-and-mortar stores in downtown Chico.Powell said an upcoming event held on a Saturday has brought up concerns for her and other business owners downtown, due to it being a busy day for businesses. "We're already struggling, and then to bring in more businesses on top of our businesses and shut our streets down is absolutely devastating," said Powell.Powell noted a decline in business during events like the Thursday Night Market, where street closures allow outside vendors to set up shop. She shared that while organizers for these types of events often offer booths to local businesses, it does not alleviate the burden."I don't really feel like that's a solution because you're bringing in other businesses, you're shutting the streets down. Yes, we can go down and set up a space, but then you've gotta pay somebody to run that space, plus run your own business for the day, and it's really not, it's really not helpful for us," said Powell.Applying for a street closure permit in Chico involves approval from the Public Works Department, the Chief of Police, and the Fire Chief. Permits can be denied only under a handful of circumstances, such as interference with first responders, previously scheduled construction, or existing permits for the same space.Mayor Kasey Reynolds addressed the issue, saying the city council has tasked staff with reviewing the municipal code for street closure permits with the goal of finding ways to minimize negative impacts on local businesses during events.Reynolds mentioned that any recommended changes might require further direction from the city council, depending on the extent of any changes recommended. googletag.cmd.push(function() { googletag.display('ad-1514992'); });
The biggest medieval march in English history never actually happened
A famous detail in the Battle of Hastings is based on a major misunderstanding.
Scientists turn probiotic bacteria into tumor-hunting cancer killers
Scientists have engineered probiotic bacteria to act as tumor-seeking drug factories. In mice, these bacteria infiltrated tumors and produced a cancer-fighting drug right where it was needed. This targeted approach could make treatments more effective and reduce side effects. More research is needed before it can be tested in people.
Data Science Use Cases: 15 Real-World Applications Transforming Enterprise Operations
Explore 15 enterprise data science applications across manufacturing, healthcare, retail, and finance — with case studies, code examples, and proven outcomes.
Microsoft Is Finally Ready to Make Windows 11 Less Terrible After Bloating It With AI Crap
Less Copilot, better search, and more taskbar customization are apparently in the pipeline.
The mental health effects of gun violence near schools
Dr. Scott Hadland from Mass. General Brigham discusses new data that shows the amount of shootings near schools is trending downwards.