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Oregon's Dante Moore Believed to be Considering Return to College Football
Following a season-ending concussion and rising NFL draft concerns, the Ducks star may bypass the pros to reclaim his momentum and health through another collegiate campaign.
Roseburg declares Small Business Season from Nov. 1 to Dec. 31, 2026
Roseburg proclaims Small Business SeasonRoseburg, OR – Mayor Larry Rich proclaimed Nov. 1 through Dec. 31, 2026, as Small Business Season in Roseburg during the
Several AEW Wrestlers Pushing Back Against Taking Losses on TV
There are apparently some wrestlers in AEW who really don’t want to stare at the lights on television. A new backstage report claims certain talent have
Smart people react to OpenAI's Exponential Time Hypothesis claim
OpenAI and Anthropic both said they've proven a long-held computer science theory false. Here's how math and tech leaders are responding.
New alliance wants Louisiana businesses to win more work from megaprojects
A new private business network aims to help Louisiana companies capture a larger share of work from the state’s growing pipeline of major industrial investments. Louisiana Launch Alliance, founded by Baton Rouge business owner Melissa Campbell, is bringing companies from different industries into an exclusive membership organization designed around sharing project information, referrals and business […]
Trump plans to loosen restrictions on methane emissions from oil drilling
President Donald Trump is expected to announce plans to loosen a Biden-era rule that aimed to reduce planet-warming emissions of methane from oil and gas drilling. The move aims to
Dodgers Likely to Discuss Contract Extension With Freeman This Offseason
Fresh off a stinging postseason exit, the Los Angeles Dodgers look to secure star first baseman Freddie Freeman as he aims to extend his career through age 40.
McCuskey says environmental groups are spreading climate science misinformation
McCuskey said West Virginia environmental groups have been misleading their supporters with inaccurate climate claims.
FACT FOCUS: Kennedy's claim that Arabs 'don't produce science' meets a Nobel Prize reality check
U.S. Secretary of Health Robert F. Kennedy Jr. has sparked controversy with comments about Arab contributions to science and literature. Speaking at a campaign event in Grand Rapids, Michigan, Kennedy
FACT FOCUS: Kennedy's claim that Arabs 'don't produce science' meets a Nobel Prize reality check
U.S. Secretary of Health Robert F. Kennedy Jr. has sparked controversy with comments about Arab contributions to science and literature. Speaking at a campaign event in Grand Rapids, Michigan, Kennedy
FACT FOCUS: Kennedy's claim that Arabs 'don't produce science' meets a Nobel Prize reality check
U.S. Secretary of Health Robert F. Kennedy Jr. has sparked controversy with comments about Arab contributions to science and literature. Speaking at a campaign event in Grand Rapids, Michigan, Kennedy
FACT FOCUS: Kennedy's claim that Arabs 'don't produce science' meets a Nobel Prize reality check
WASHINGTON (AP) — Health and Human Services Secretary Robert F. Kennedy Jr.'s broad assertions about Arab contributions to humanity's scientific and literary discoveries at a Republican campaign event in Grand
FACT FOCUS: Kennedy’s claim that Arabs ‘don’t produce science’ meets a Nobel Prize reality check
WASHINGTON (AP) — Health and Human Services Secretary Robert F. Kennedy Jr .'s broad assertions about Arab contributions to humanity's scientific and literary d
FACT FOCUS: Kennedy’s ‘Arabs don’t produce science’ claim meets a Nobel Prize reality check
His remarks have been widely condemned as untrue and racially biased.
FACT FOCUS: Kennedy's 'Arabs don't produce science' claim meets a Nobel Prize reality check
WASHINGTON (AP) — Health and Human Services Secretary Robert F. Kennedy Jr.'s broad assertions about Arab contributions to humanity's scientific and literary discoveries at a Republican campaign event in Grand Rapids, Michigan, have drawn criticism just days before midterm elections.
FACT FOCUS: Kennedy's 'Arabs don't produce science' claim meets a Nobel Prize reality check
WASHINGTON (AP) — Health and Human Services Secretary Robert F. Kennedy Jr.'s broad assertions about Arab contributions to humanity's scientific and literary discoveries at a Republican campaign event in Grand
FACT FOCUS: Kennedy’s ‘Arabs don’t produce science’ claim meets a Nobel Prize reality check
U.S. Secretary of Health Robert F. Kennedy Jr. has sparked controversy with comments about Arab contributions to science and literature.
FACT FOCUS: Kennedy's 'Arabs don't produce science' claim meets a Nobel Prize reality check
U.S. Secretary of Health Robert F. Kennedy Jr. has sparked controversy with comments about Arab contributions to science and literature. Speaking at a campaign event in Grand Rapids, Michigan, Kennedy
FACT FOCUS: Kennedy's claim that Arabs 'don't produce science' meets a Nobel Prize reality check
U.S. Secretary of Health Robert F. Kennedy Jr. has sparked controversy with comments about Arab contributions to science and literature.
FACT FOCUS: Kennedy's 'Arabs don't produce science' claim meets a Nobel Prize reality check
U.S. Secretary of Health Robert F. Kennedy Jr. has sparked controversy with comments about Arab contributions to science and literature.
Trump visits Lubbock and Corpus Christi as Republicans fight to hold Texas’ U.S. Senate seat
With just a week until Election Day, President Donald Trump is making his fourth trip to Texas this campaign season. At rallies in Lubbock and Corpus Christi, the president aims to boost Republican voter turnout and shore up support for U.S. Senate nominee Ken Paxton.
Trump visits Lubbock and Corpus Christi as Republicans fight to hold Texas’ U.S. Senate seat
With just a week until Election Day, President Donald Trump is making his fourth trip to Texas this campaign season. At rallies in Lubbock and Corpus Christi, the president aims to boost Republican voter turnout and shore up support for U.S. Senate nominee Ken Paxton.
Someone just got the Switch 2's Mario Kart World running on a Mac, and Nintendo probably isn't thrilled
The game is still a bit of a mess, but it seems very playable.
Cowboy Space unveils 'Big Iron' rocket to launch 20,000 AI data centers
Cowboy Space aims to launch the 282-foot-tall (86 meters) Big Iron for the first time in late 2028.
My favorite robot vacuum just got quieter, and more expensive
The new Matic Serene claims to be as quiet as your refrigerator while cleaning your floors. But it will cost you $1,700.
Collin Gosselin responds to mom Kate Gosselin’s claims about his ‘history of violent behavior’
Collin’s rep claims Kate is “beyond reprehensible,” and her allegations against her son are “categorically false.”
RFK Jr accused of ‘blatant bigotry’ after claiming Arabs ‘don’t produce science or literature’
Health secretary suggests Middle Eastern Muslims do not win major prizes because their religion holds them back, a claim branded ‘factually inaccurate’ and offensive
Hearts vs. Rangers: Match Preview
High-scoring Hearts aim to bridge the gap at Tynecastle, but Rangers stand in their way as Derek McInnes returns to face his former club.
Exclusive: Meta director Rohit Patel departs after 8 years to take on Microsoft Office Suite
Rohit Patel is departing Meta after eight years working on AI evaluations and reinforcement learning, TechCrunch has exclusively learned. His startup, Ndoc, aims to take on Microsoft Office Suite.
Nathan Fielder's Elizabeth Holmes documentary 'You Can See Everything' ended, but the story didn't. Here's what's happened since.
Warning: Don’t read this article if you haven’t seen Fielder's critically acclaimed film, as it contains plenty of spoilers.
Trump administration asks Washington state to hold more than 400 people’s ballots
The Justice Department has claimed the individuals may not be eligible to vote, weeks after making a similar request in California.
’They don’t produce science’: RFK Jr’s anti-Arab claims checked
RFK Jr claimed Arabs produce no science or literature and win no major awards. The New Arab fact-checks his remarks against decades of Arab achievements.
Sale of Trinidad Business
TORONTO, ON AND LONDON, UK / ACCESS Newswire / October 27, 2026 / (TSX-V:SEI)(AIM:SEI)(OTCQX:SEUSF) ("Sintana" or the "Company") announces that the first instalment of $450,000 in deferred consideration for the sale of its business in Trinidad in 2025 has been received.It is noted that the Company had agreed with the purchaser a variation of terms for the deferred consideration payment instalments, such that full payment of all outstanding amounts, less an agreed early payment discount, are to b
Bloober Team’s Silent Hill remake is set for a 2027 release with the first two actors named, report claims
Two actors are reportedly attached to the project, but the role of Harry hasn’t been confirmed…
Did the Hardest A.I. Problem Just Get Much Easier?
A prominent researcher claims to have a revolutionary approach to “interpretability,” or the science of why A.I. models do what they do. Other experts aren’t so sure.
The case for 'Climate Popularism’: A new politics for an age of ecological crisis
Climate resilience and adaptation remain largely neglected in UK politics, a glaring omission our proposal aims to address.
Japanese investment group claims JYP takeover, raising questions over credibility
An obscure investment group claiming to be based in Japan sparked controversy in the K-pop industry Monday by announcing plans to acquire a controlling stake in
A-State researcher lands NSF award
Arkansas State University has received a National Science Foundation (NSF) award totaling $177,108 to support research aimed at making waste-to-energy systems more efficient, sustainable, and environmentally friendly. Dr. Chiqian Zhang,...
New Australian Platform Aims to Simplify Celebrity and Entertainment Bookings
Booking Australian musicians, comedians, celebrities and other entertainers could be about to get easier, with the launch of an expanded talent directory
Court dismisses claims against former UVA Health leaders in suit
CHARLOTTESVILLE, Va. (CBS19 NEWS) -- A federal court has dismissed several claims against former UVA Health CEO Dr. K. Craig Kent and other former health system leaders in a lawsuit
OpenAI Science Discoveries: 3 Claims, ETH, QCD [2026]
OpenAI science discoveries: a claimed ETH disproof, Kakeya proof and QCD existence proof, with academic shepherds. What is verified so far.
New McKinleyville BMX track opens, aiming to boost tourism and local business
A new BMX racing facility in McKinleyville is giving local riders a dedicated place to compete, while community leaders hope it will also draw visitors...
OpenAI Claims 3 Science Proofs, Taps Shepherds [2026]
OpenAI science discoveries in math, computer science and physics: what the three claims say, what is verified, and how the shepherd model works.
OpenAI announces three ‘major’ science discoveries in math, computer science and physics
OpenAI claims three major breakthroughs in physics, mathematics and computer science, including resolving two mathematical conjectures and challenging ETH. | World News
California ballots targeted by Trump can be counted for now under court ruling
The ruling is a blow to the Trump administration, which claimed the ballots might have gone to noncitizens and wanted to set them aside.
Amid her reelection bid, Hochul aims at retaking Congress
Hochul spoke exclusively with NY1.
Block Announces Healthcare Initiatives, Calls Foulkes’ Claims False
GoLocalProv.com is the “go to” local Web experience that breaks the biggest local stories – sports, news, business, weather, news, politics, arts,…
Appeals court rejects Trump DOJ demand to set aside 20,000 California mail ballots
A federal appeals court on Monday rejected the Trump administration’s unprecedented attempt to force California to set aside votes from 20,000 people it claims are noncitizens.
Trump DOJ charges James Comey for a third time as political retaliation claims mount
Comey has denied wrongdoing in the cases against him and said Monday, “I’m still innocent.”
Shared framework aims to redefine heart health for girls and women
The American Heart Association, American Academy of Pediatrics, American College of Obstetricians and Gynecologists and the Society for Maternal-Fetal Medicine have released a publication that redefines ...
El-Sayed responds to Trump’s anti-Muslim rhetoric
At a rally in Michigan on Sunday, Trump escalated false claims that El-Sayed is a jihadist and a member of the Muslim Brotherhood
Minogue, State Police union embroiled in pre-election war of words
The State Police Association of Massachusetts has demanded an apology from gubernatorial candidate Mike Minogue, but he claims Gov. Maura Healey is the one who should say she's sorry.
Call Sheet Media Welcomes Acclaimed Musician and Entertainment Industry Veteran Lori Andrews to Its Team
Acclaimed jazz harpist Lori Andrews brings decades of entertainment experience, creative leadership, and industry connections to Call Sheet Media.
Keith Ellison sues businesses accused of stealing millions from child nutrition programs
The suit claims Nasib Bakery Food Distribution, LLC, and East African Health Network submitted millions of dollars in false claims to the Minnesota Department of Education.
6 citizens sue Trump, saying media ban deprives them of news as audience stakeholders
A new lawsuit against President Donald Trump's media ban stakes a claim for the public itself. The lawsuit was filed on behalf of six ordinary citizens. It argues that Trump's
Trump heads to Mississippi as Democrats put deep-red states in play
With Sen. Cindy Hyde-Smith (R-Missisippi) locked in a surprisingly close contest with Democrat Scott Colom, Trump was aiming to rev up his MAGA base to vote amid growing signs of an impending Democratic blue wave.
Madigan Brings Occupational Health Services to Yakima Training Center, Aims to Reduce Travel By 90%
YAKIMA TRAINING CENTER, Wash. — Madigan Army Medical Center brought occupational health services directly to civilian employees at Yakima Training Cente...
UC Berkeley scientists eye life abroad as Trump administration politicizes research
Some are considering programs run by France, Canada and other countries that aim to recruit weary U.S. researchers.
More women are dying from heart disease. New guidelines for doctors aim to change that.
Heart disease is the No. 1 killer of women in the U.S. — a threat that's projected to rise significantly over the next two decades. A new approach to care hopes to change that.
More women are dying from heart disease. New guidelines for doctors aim to change that.
Heart disease is the No. 1 killer of women in the U.S. — a threat that's projected to rise significantly over the next two decades. A new approach to care hopes to change that.
Kate Gosselin Claims She Visited Son Collin at Mental Health Facility ‘Every Single Time’ She Could
The former reality star’s estranged son Collin Gosselin, now 22, detailed his childhood trauma in a new memoir titled ‘In the Shadow of Eight: Surviving the Reality of My Childhood’
Umios to acquire High Liner Foods to expand North American seafood business
High Liner Foods has agreed to be acquired by Japanese seafood group Umios in a deal aimed at strengthening the companies’ positions in North American seafood.
📈 Monday data: The bottleneck isn’t intelligence
In the AI Investment Brief today: CapEx updates and lease commitment breakdowns Anthropic co-founder Jack Clark recently said in a speech at the IMF that the singularity has begun: For many years, researchers and science fiction authors have forecast a future in which AI systems drastically increase the pace of overall scientific and technical progress, making things move so quickly that it is hard for humans to keep up. They call this the singularity. I believe that this year we have gained convincing evidence that it has now begun. This follows Anthropic’s claim that in August, 26% of its AI R&D was led by Claude, with a human supervising its work. In October, OpenAI posted 719 math manuscripts1 made by its internal model. Math and coding are two fields where a research loop can close without leaving the desk. But can the loop close in the rest of science? Subscribe The loop is real The idea is not new. Mathematician Irving John Good, who had worked with Alan Turing at Bletchley Park, argued that a machine smarter than us “could design even better machines; there would then unquestionably be an ‘intelligence explosion,’ and the intelligence of man would be left far behind.” The Gödel machine, a self-improving computer that can rewrite its own code better than its prior, was first proposed in 2003. In 2025, researchers at Sakana AI and the University of British Columbia set out to show that this was possible. Their agents iteratively improved their own code through a feedback loop, resulting in gains of 30 pp on SWE-bench and more than 15 pp on Polyglot, testing coding skills beyond Python. The idea has since been tested in other labs. A Gemini-powered agent called AlphaEvolve found a faster matrix multiplication kernel used for training Gemini, speeding up the kernel by 23% and cutting Gemini’s training time by 1%. In China, MiniMax reported that its M2.7 model worked on improving its own agent’s harness, skills, sampling and memory. Over 100 rounds of rewriting led to a 30% gain, per its internal evaluations. In each case, what was being rewritten was not the model itself but everything around it. Is it better than human work? In September this year, in what seemed like a milestone, an AI-built agent proved as good at improving other AI agents as a human-built one. It did that in what appeared to be half the steps. But the result was inconclusive: the differences between runs were greater than the difference between the AI- and human-built agent results. Nonetheless, this is increasing the chatter around recursive self-improvement (RSI) in AI. Google’s Sundar Pichai said that “you have RSI loops along with AI researchers in various aspects of model development.” Sakana AI published a paper on RSI through multi-agent collaboration, finding that after two cycles its system scored 1.2–1.6x better per output token than the base model across four research benchmarks. Ramez Naam challenges that view. He splits AI self-improvement into five overlapping types. The first four describe how autonomous the AI is; so far, only types 1 and 2 have been observed. The fifth type describes accelerating returns, and he notes that greater autonomy doesn’t guarantee a takeoff scenario. Instead, each round of self-improvement would need to deliver at least as much as the last. The results from Sakana, AlphaEvolve and MiniMax above might look like type 3 or type 4 autonomy. But in each case, the AI wasn’t updating its own weights directly, only the ancillary parts — the harness, the memory. And where Claude leads its own R&D, for now a human still supervises.
6 citizens sue Trump, saying media ban deprives them of news as audience stakeholders
A new lawsuit against President Donald Trump's media ban stakes a claim for the public itself.
One Radio Source In Our Galaxy Has Been Producing Signals For At Least 20 Years That No One Can Explain
Still not aliens, but one of the weirdest things we have found in a sky where weird things are not in short supply.
Kennesaw State researcher explores virtual reality to improve student engagement in STEM
A Kennesaw State University researcher is exploring how virtual reality can help students stay focused and engaged during science and engineering laboratory activities. Supported by a $198,486 grant from the National Science Foundation (NSF), the research aims to help learners maintain attention, improve motor skill, and enhance learning in immersive virtual laboratories. Sungchul Jung, an assistant professor of gaming in KSU's College of Computing and Software Engineering, is leading the two-year project.
Utah is one of the best states for business — but most are run by men. This free 15-week program aims to change that.
The free program is a "safe, inclusive environment" where Utah women can learn to write a business plan and understand their financials. Applications are due Oct. 30.
Two encouraging stats after Inter’s latest comeback victory
Inter had to come from behind yet again to claim a 2-1 victory over Fiorentina in Serie A on Sunday afternoon, which has kept the Nerazzurri at the top of the league table for another week and has pro...
Michigan’s new $82M unemployment system launches Nov. 9 after long development process
The new MiUI system will allow unemployed workers to file claims, certify for benefits, view payments and do other tasks through the platform.
Mental health event aims to support those who serve and protect
“Resilience: From Service to Strength” is an Oct. 27 Rockledge event focused on mental health for veterans, military and first responders.
Free Agent Relievers the Cardinals Could Sign This Offseason
With a lockout looming, an offseason freeze between players and teams makes it even harder to predict the St. Louis Cardinals’ next moves. The franchise is seemingly continuing to slow-play its rebuild, with President of Baseball Operations Chaim Bloom not committing to any eye-popping moves after the club finished 76-83 in 2026. But even if …
Many Medicare Patients Could Lose Access to Remote Monitoring Devices
A proposed federal rule could dramatically reduce access to remote patient monitoring programs for people on Medicare. The services aim to keep patients out of the hospital by giving them devices to monitor their health at home, but critics say there isn’t enough oversight.
The youngest Ballon d’Or winners in history
Ronaldo Nazário remains the youngest player to win the Ballon d'Or, having claimed football's most prestigious individual honour aged just 21 years and 92 days in 1997.But could the Brazilian's long-...
IRGC Spokesman Mocks CENTCOM Chief over Hormuz Flight
TEHRAN (Tasnim) – IRGC Spokesperson Brigadier General Hossein Mohebbi urged CENTCOM Commander Brad Cooper to face reality after his flight over the Strait of Hormuz, using the latest oil price to challenge Washington’s claims that the strategic waterway remains open.
Inglewood Starts Transit Development
Last week, Inglewood city officials broke ground on their scaled-down $261 million Inglewood Transit Connector project aimed at improving mobility between
Ballon d'Or 2026: Harry Kane, Kylian Mbappe and Lamine Yamal in race for men's award
Harry Kane, Lamine Yamal and Kylian Mbappe battling for 2026 mens Ballon dOr on Monday; Kane odds-on favourite to become first Englishman to win the award in 25 years; Lamine Yamal, 19, aiming to become youngest-ever Ballon dOr winner; Sky Sports Jamie Carragher backing Kane to win
Cole Caufield’s Canadiens claim will surely divide fans across Canada
The Montreal Canadiens are having a fine start to the 2026-27 NHL season. Cole Caufield and his teammates are looking to return to the Stanley Cup Playoffs. In outdoor conditions on Sunday, Caufield was a big star for the Habs against the Winnipeg Jets. The Canadiens defeated the Jets 2-1 in the Heritage Classic at Princess Auto Stadium in […] The post Cole Caufield’s Canadiens claim will surely divide fans across Canada appeared first on ClutchPoints.
Holland Taylor says ‘Two and a Half Men’ ‘never paid me very well,’ even after 4 Emmy noms
Holland Taylor is looking back on her 12-season run on ‘Two and a Half Men,’ during which time, she claims she never got a raise: ‘I loved a lot about that show, but they were not full of courtesies.’
Kings’ Mogbo Wants To Set Defensive Tone in G League
Armed with a 7-foot-2 wingspan and relentless hustle, the two-way forward aims to spark Stockton’s defense through gritty rebounding and elite shot-contesting while eyeing a permanent NBA promotion.
Xbox console users will receive 50 games from October 26 to 31.
From October 26th to 31st, the Xbox ecosystem and Xbox PC service will receive a major expansion of their catalog, including the release of 50 new games for...
Trump escalates rhetoric against El-Sayed as he tries to undermine Democrat in Michigan Senate race
The Republican president has been attacking El-Sayed's faith throughout the campaign and claiming his past statements and background show a sympathy for extremists.
Brad Pitt's Underrated Sci-Fi Astronaut Movie Deserved Better At The Box Office
You likely missed this critically acclaimed Brad Pitt sci-fi thriller when it was in theaters, but it's a film that warrants a watch.
Bayern beat Freiburg to reclaim top spot after Kompany illness
Bayern Munich reclaimed top spot in the Bundesliga with a 3-1 win at Freiburg on Sunday, days after coach Vincent Kompany was hospitalised when he collapsed at training.With coach Kompany still in hospital after collapsing on Friday, Englishman Danks was in the dugout.
Defender turns striker and scores in Bayern win
Bayern Munich beat Freiburg 3-1 away from home to reclaim top spot in the Bundesliga on Sunday (25).Dayot Upamecano was one of the standout performers, scoring the opener with a move in which he playe...
Nico Williams publicly disavows his agent over Barcelona transfer claims
Barcelona’s long and drawn-out pursuit of Nico Williams has become one of the more familiar sagas of recent transfer windows.The Athletic Club winger ultimately opted to stay at San Mames, snubbing ...
Epic CEO Tim Sweeney lambasts “abhorrent” Steam AI Disclosure Policy claiming labels double as “political statement”
Epic Games CEO Tim Sweeney called Steam’s AI disclosure policy abhorrent, arguing that it exposes developers to backlash from anti-AI detractors. Valve has implemented and updated the policy since 2024, which states that AI-generated content, including artwork, text, music, and assets, excluding assistant tools, requires formal disclosure.
Photographer and medical professionals connect science and art during panel discussion
In 2020, the world was put on hold because COVID-19 began claiming the lives of people all over the globe. When a vaccination for the illness was finally made public in 2021, being vaccinated became highly politicized. Instead of focusing on the emotional reactions that people had toward the vaccine, artist Linda Alterwitz was more...
ESMO: Roche touts ‘convincing’ phase 3 KRAS data after win over rivals
Roche has shed more light on its investigational KRAS G12C inhibitor's phase 3 victory over Amgen’s Lumakras and Bristol Myers Squibb’s Krazati. The open-label Krascendo 1 trial enrolled 338 people with previously treated KRAS G12C-mutated non-small cell lung cancer (NSCLC). Patients who had already received a KRAS G12C inhibitor or pan-KRAS/RAS inhibitor were excluded from the trial. Participants received either divarasib once daily, Lumakras once daily or Krazati twice daily. Roche announced back in July that divarasib had demonstrated statistically significant improvements in progression-free survival (PFS) and overall survival (OS), meeting the trial’s primary and key secondary endpoints. But the Swiss pharma had been holding back the detailed data until now. At the European Society for Medical Oncology (ESMO) Congress in Madrid, Roche revealed that median OS for the 167 patients who received divarasib was 17.7 months, compared to 12 months for the 171 patients who received Lumakras or Krazati. The benefit was similarly clear when it came to median PFS, which stood at 9.8 months versus 5.7 months, respectively. A total of 44% of patients receiving divarasib were alive without disease progression at one year, compared to 24% of the control group, according to Roche’s presentation. It was a similar story for the objective response rate, which came in at 58% for divarasib versus 32% for the control group, while median duration of response was 11.9 months versus 6.9 months. Stefan Frings, M.D., Ph.D., deputy chief medical officer at Roche Pharma, told Fierce that the data made for a “very comprehensive, strong package, which should be convincing to health authorities.” “It’s an important advance for patients with lung cancer,” Frings said in an interview at a Madrid hotel during the conference. “It's a second-line setting, and patients who receive divarasib benefit compared to the current first-generation KRAS G12C inhibitors by having far longer overall survival,” he continued. “They live longer. They have better progression-free survival, better response rates, and with a safety profile which is—if [anything]—even better,” he said. According to Roche, 4.8% of patients receiving divarasib discontinued treatment due to treatment-related adverse events, compared to 11.7% in the control group. Serious treatment-related adverse events were also less common with divarasib, at 7.8% versus 15.2%. Roche’s confidence in divarasib had been building even before this phase 3 success. The candidate had already shown better potency and selectivity than the incumbent KRAS G12C inhibitors Krazati and Lumakras in preclinical tests. After cross-trial comparisons suggested that the edge translated into better clinical outcomes, Roche axed a study comparing divarasib to the chemotherapy docetaxel and went toe-to-toe with Lumakras and Krazati. “We designed the drug on purpose with higher potency and better selectivity,” Frings explained. “So, based on preclinical models, we clearly knew it would be superior to the first generation.” “It’s honestly not so frequent that pharma companies go head-to-head,” he added. “But if you want to make a point, if you want to convince payers, prescribers and patients … then a head-to-head win is rather rewarding.” While Amgen and BMS reached the regulatory finish line first for KRAS G12C-mutated, locally advanced or metastatic NSCLC in 2021 and 2022, respectively, they have struggled to capitalize on their head start. Krazati brought in $55 million for BMS in the second quarter, while Lumakras delivered $111 million to Amgen. For its part, Roche is aiming for peak divarasib sales of 1 billion to 2 billion Swiss francs ($1.2 billion to $2.5 billion), according to Frings. The Big Pharma is currently recruiting patients into a phase 3 trial comparing divarasib plus Keytruda against Keytruda plus chemotherapy in previously untreated advanced or metastatic nonsquamous KRAS G12C-mutated NSCLC. Roche has previously suggested that sales in metastatic disease would account for most of the forecast. Frings was tight-lipped on the exact timeline for a regulatory filing but said the Swiss pharma is “certainly keen to get this to as many patients as possible around the world.” Roche has more RAS drugs coming up behind divarasib. The pharma has already launched phase 1 trials of a pan-RAS inhibitor called RG6505 and a KRAS G12D inhibitor dubbed RG6620 in solid tumors. Roche’s partner Chugai Pharmaceutical is also testing a pan-KRAS inhibitor called AUBE00. Roche has made a “deliberate effort” to test a range of RAS drugs, Frings said. “If you have many rare mutations and you are scrambling to find sufficient patients, a pan-RAS inhibitor makes a lot of sense,” he explained.
Trump's midterm swing brings him to Michigan as Republicans aim to undermine El-Sayed in Senate race
President Donald Trump's busy midterm campaign schedule is bringing him to Michigan, where Republicans hope to claim an open Senate seat on Election Day | Newsradio 1140 WRVA
Trump's midterm swing brings him to Michigan as Republicans aim to undermine El-Sayed in Senate race
President Donald Trump's busy midterm campaign schedule is bringing him to Michigan, where Republicans hope to claim an open Senate seat on Election Day.
Trump's midterm swing brings him to Michigan as Republicans aim to undermine El-Sayed in Senate race
President Donald Trump's busy midterm campaign schedule is bringing him to Michigan, where Republicans hope to claim an open Senate seat on Election Day.
U of M fellowship aims to boost rural obstetrics training and keep labor and delivery units open
The partnership is launching the new, one-year family medicine obstetrics fellowship next summer to prepare family medicine physicians to provide advanced prenatal, maternity and newborn care in rural communities. The only other fellowship of this kind in Minnesota is at Essentia Health in Duluth.
Udinese vs AC Milan – Match preview and team news
AC Milan will aim to get inside the top four of the Serie A league table by securing all three points when they meet Udinese on Sunday away from home in their next match.Udinese vs AC Milan – Match...
What gets fact-checked? How politics shapes the answer in four African countries
Many fact-checkers are moving away from declaring claims as true or false, and trying to help people judge information for themselves.
VT Science Corner: Expanding eating disorder care to rural areas
The great Taylor Swift proclaimed “I’m the problem, it’s me” in her 2022 song, "Anti-Hero." This lyric reflects something many people can recognize: the belief that something is fundamentally wrong
Inter Milan vs Fiorentina – Predicted lineup and team news
Inter Milan welcome Fiorentina to the San Siro on Sunday for their next Serie A game, aiming to climb to the summit of the table.The Nerazzurri arrive in outstanding domestic form, having avoided defe...
Evander hits Messi-esque levels of production for FC Cincinnati
By Jaime UribarriIs Evander the best player in Major League Soccer not named Lionel Messi?FC Cincinnati’s All-Star Brazilian playmaker has looked the part throughout his MLS career and further stren...