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Beloved Lakeview Electronics Shop Where Neighbors Found 'Hidden Gems' Closing After 55 Years
Lakeview's Royal Home Entertainment is selling off its remaining inventory ahead of its closure Saturday, though owner Joe DeGuide still plans to offer custom installation services online.
Lainey Wilson joins Mohegan Sun Walk of Fame
Lainey Wilson was inducted into the Mohegan Sun Walk of Fame during the resort's 30th anniversary celebration.
What To Expect From Joe Musgrove in 2027
Veteran starting pitcher Joe Musgrove made his long-awaited return to the San Diego Padres, closing out Game One of the NL Wild Card series after a surprise addition to the postseason roster. He pitched another two innings against the Milwaukee Brewers in Game 4 of the NLDS. After some command issues in his first appearance, …
Travis Kelce reveals terrifying Steelers Combine meeting detail
Mike Tomlin explained how the Pittsburgh Steelers used Hall of Famer Mean Joe Greene during draft combine meetings to test incoming prospects.
Layoffs and business closures loom as tens of thousands of skill games become illegal
Joe Rocca’s business effectively ended Wednesday as the enforcement of Pennsylvania’s skill games ban began. Rocca, owner of Rite Touch Distribution...
Troy Aikman, Joe Buck reportedly got into argument in 'Monday Night Football' booth over contract extension tensions at ESPN
Hazle Township Early Learning Center enjoy science program
On Oct. 5, second-grade students at the Hazle Township Early Learning Center participated in a Title I federally funded parent engagement program, Joe Romano’s Is it Magic or Science? This event was organized to promote literacy within s…
Houston Astros part ways with manager Joe Espada
The news comes one day after a report that Espada was granted permission to interview for the Mariners manager role.
Mariners News: Joe Espada, José Ramírez, and Don Mattingly
We’ve got our first official name in the Mariners’ managerial search. Plus, the Phillies lock in their 2027 skipper.
Joe Manganiello says Armie Hammer-recommended second shaman told him he wasn’t meant to marry Sofía Vergara
Joe Manganiello said a shaman suggested his marriage to Sofía Vergara was a ‘booby trap’ that led to his mysterious autoimmune disease.
Byrum Brown's Turnovers Headline Joel Gordon's Concerns Before Georgia
Auburn offensive coordinator Joel Gordon addressed three major concerns ahead of facing No. 1 Georgia: Byrum Brown's interceptions, slow offensive adjustments and pre-snap penalties. The Tigers must improve their decision-making and execution to compete in Athens.
Your 2026 Week 7 college football announcing schedule
Week 7 of the 2026 college football season will feature several marquee matchups, including two battles of teams ranked in the top 10. No. 4 Ohio State and No. 5 Indiana will meet for a showdown in the “Big Noon” slot for Fox, with Gus Johnson and Joel Klatt on the call. ESPN’s College GameDay…
Joe Manganiello unpacks his health scare in memoir, “Bloodlines”: ‘I can’t believe I got through it’
The “One Piece” star tells “Entertainment Weekly” about his experience revisiting his seven-year-long health battle for the memoir, which is available now.
Dean of St. Joe’s business school, its biggest college, is retiring
With 27 years at the Erivan K. Haub School of Business and 13 at Widener University, Joseph DiAngelo says he is the longest-serving business school dean in the U.S.
Joe Manchin endorses independent in Iowa’s 1st District race
Independent Michael Bridgford, endorsed by former U.S. Sen. Joe Manchin, is working to connect with voters in Iowa’s 1st congressional district race against Republican Mariannette Miller-Meeks and Democrat Christina Bohannan.
Joe Manganiello: Sofía Vergara Ridiculed Him Over Dog During Health Scare
In his memoir 'Bloodlines,' the actor says his then-wife refused to hug him, and mocked him for the chihuahua that helped him at a time when he was dealing with a seven-year illness.
Joe Burrow’s model girlfriend Olivia Ponton reveals personal health battle
Cincinnati Bengals quarterback Joe Burrow’s model girlfriend, Olivia Ponton, recently opened up about a personal health battle. The Sports Illustrated Swimsuit model admitted she struggles with the ea...
Ayotte highlights housing, cellphone ban in comic campaign s...
Gov. Kelly Ayotte and first gentleman Joe Daley reprise their campaign-ad banter as her reelection race enters its final three weeks.
2026 Election Preview: 137th Legislative District
The midterm elections are less than four weeks away and PoliticsPA has identified 19 State House races throughout the Commonwealth to focus on during the run-up to the 2026 election, as part of our 31 Races in 31 Days series. HD-137: Joe Emrick (R) v. Jeff Warren (D) The Key…
Bills DT Oliver, WR Palmer ruled out for Monday Night Football
According to head coach Joe Brady, Palmer hurt his shoulder in practice and Oliver did not practice this week because of a knee injury.
Joe Burrow calls Bengals’ Perine ‘Mr. Reliable’ after Dolphins win
Joe Burrow praised Samaje Perine as “Mr. Reliable” after the veteran running back helped the Bengals beat the Dolphins.
Joe Burrow tosses four TDs in Week 5
Cincinnati Bengals quarterback Joe Burrow completed 23 of 32 passes for 190 yards, four touchdowns and no interceptions in Week 5
Marlon Brando had key connection to Disney legend’s mom — whom Don Rickles also ‘had a crush’ on (exclusive)
“He’d go, ‘Julie! Admit it! You love me!’” Joe Rohde tells EW on stage at New York Comic Con.
Bills' Joe Brady has empathetic ear in Rams' Sean McVay
McVay can appreciate what his Bills counterpart is going through after having been in a similar position not long ago.
Voters have many reasons to be upset
The rising costs of fuel, food, and housing are wearing on people, and the labor market isn't helping, economist Joel Naroff writes.
UConn Football Alum to Be Active For First NFL Game
Joe Fagnano is going to get his first shot to be active for an NFL game.
Hefley Calls Interstate System a ‘Money Machine’
Forty-five years ago this week: “There are enough new interstate highways in this country,” said state Rep. Joel Hefley, R-Colorado Springs and the time has come to stop adding new projects and to start taking care of the existing highways.” Hefley even suggested that the interstate highway completion program should be discontinued because it encouraged […]
Chargers Injury Report: Quentin Johnston, Derwin Hames OUT vs. Broncos
The Chargers will be without Joe Alt, Derwin James, and Quentin Johnston this week against the Broncos.
Diamondbacks bringing back hitting coach Joe Mather
Joe Mather has been the Diamondbacks' hitting coach since the start of the 2022 season.
Poll: Young voters think there is too much money in politics
A new poll out this morning reveals young American voters from all political backgrounds think there is too much money in politics. They also believe rich people and wealthy organizations have more influence on members of Congress than the individuals who vote for them. MS NOW contributor, author and pollster John Della Volpe joins Morning Joe to discuss the findings — along with Jeff Clements, the CEO of American Promise, a nonpartisan group focused on reducing the influence of money in politics, which commissioned the poll.
Mitchell Robinson on Joe Mazzulla's coaching style with Boston Celtics
"What you see is what you get," said Robinson in a recent interview.
Joe Buck to guest star on ‘Dancing with the Stars’
Disney knows no bounds when it comes to promoting the fact that ABC and ESPN are showing the Super Bowl this year. And that includes one of their longest-running entertainment franchises, Dancing with...
Charlotte Motor Speedway to host celebration of life for Kyle Busch
The event after the Trucks Series race will include Kyle Busch’s widow, Samantha, team owner Joe Gibbs and several Cup Series drivers.
Scientists create new statewide surface geologic map of Nebraska
A new academic paper by Paul Hanson and Matthew Joeckel of the Conservation and Survey Division in the University of Nebraska–Lincoln's School of Natural Resources contains a brief phrase—"new linework"—that ...
Lions Trade Buzz Heats Up Around $20M Cornerback
Now that the Detroit Lions have moved on from pursuing Joey Porter Jr., it appears the cornerback most connected to the team is Kristian Fulton of the Kansas City Chiefs. Jeremy Fowler of ESPN poured more fuel on the speculation fire by offering Fulton as a strong option to tie to the Lions before the […] The post Lions Trade Buzz Heats Up Around $20M Cornerback appeared first on HEAVY.
Trump bucks and the politics of mailing checks
The checks started going out last week, nearly one million of them, and mostly to battleground states. With a return address for the U.S. Treasury and a letter enclosed signed by President Donald Trump, these one-time checks for $500 were ostensibly government rebates for Obamacare enrollees who overpaid. In the accompanying letter, however, Trump attacks his predecessor and talks about his record in office on an important issue he’s not polling well on, which makes it seem more like the most expensive political mailer in U.S. history. The average piece of direct mail costs between 30 cents and $3, according to Mail Processing Associates, a print, mail, and fulfillment company. At $500 a pop plus roughly 50 cents each to issue the paper check, the cost of Trump’s healthcare mailer sent to more than 950,000 enrollees comes in at more than $475 million. Trump’s midterm healthcare message “For years, the Biden Administration overcharged you to fund the operation of HealthCare dot gov,” Trump wrote in the letter. “That money belongs to hard-working Americans, not the Government, and now, I am returning it to you!” In the letter, Trump makes false and misleading claims about his administration’s record on healthcare costs, an issue Democrats have a 20 point advantage on over Republicans, according to a recent poll from KFF, a nonpartisan health policy think tank. Trump touts his administration’s TrumpRX program, which he claims is “delivering massive discounts.” However, new research from KFF found that of a selection of drugs available on the TrumpRX platform, just five were the lowest price, while 13 were the highest price. Trump also falsely claims in the letter that he’s fighting to lower healthcare costs. In reality, average monthly premium payment costs for enrollees rose 58% under Trump while marketplace sign-ups declined 5%, per KFF. Under Trump’s One Big Beautiful Bill Act, it’s estimated 10 million more Americans will be uninsured by 2034. You get a check and you get a check and you get a check Trump’s long promised cash outs to his fans, from his days as a casino operator and gameshow host to his presidency. During the early days of the COVID-19 pandemic in 2020, the first Trump administration made the unprecedented move to put Trump’s name on checks that went out under the CARES Act (notably the $500 refund checks this time around don’t feature Trump’s name). Ever since, Trump’s been chasing that high. In his second term, Trump’s promised more stimulus that never arrived, like refund checks from DOGE cuts and tariffs, while he said at his party’s convention last month that he’d give out $5,000 checks to everyone if Republicans win in November. In reality, DOGE overstated its cost cutting and Trump’s government actually now spends more than former President Joe Biden’s, while Trump’s tariffs actually grew the trade deficit. His proposal for $5,000 checks would add about $1.2 trillion to the national debt. The problem is there’s no money to give. These $500 checks — plus $90 Medicare rebate checks also going out as well as $250 deposited this week in some Trump Accounts for kids courtesy Dell Technologies CEO Michael Dell and his wife Susan — represent the closest Trump’s going to get to making good on his promise to deliver cash fast. And the checks seem especially targeted. Though the $500 checks went out to enrollees in one of 30 states that use the federal HealthCare dot gov marketplace, a Reuters review found 71% of the payments, or $339 million, went to enrollees in 13 states that have the most competitive elections for governor and U.S. Senate. Most Americans don’t buy it Could Trump bucks sway the election? An Economist-YouGov poll found 57% of U.S. adults doubt Trump will deliver on his promise for $5,000 checks, compared to 21% who do. “I’m waiting on my DOGE check and I’m still waiting on my tariff check,” one 2024 Trump voter who’s since turned on him told a recent focus group. “It felt like kind of trying to buy people’s votes, which honestly felt like in elementary when the class president was like, hey we’re going to take you to the water park if you vote for me. It’s like, I don’t think it works like that.” But for voters in swing states who got a check, it could still matter. One survey published in 2022 found receiving a physically personalized check in the mail during the pandemic was associated with a much greater self-reported likelihood of voting for Trump in 2020, and those gains mainly came from out partisans. The issue for Trump comes if these checks are mostly going to Obamacare enrollees whose premiums have gone up by more than just $500 since he took office and who view the money as something like a bribe before the election rather than an actual long-term solution to lowering household costs. Spending $500.50 per mailer would be absurd as a normal campaign expenditure, but since Trump’s checks and letter are a government rebate, his campaign and super PAC didn’t have to spend a dime and he got out his message regardless. If enough voters in key states are swayed by the one-time payment, it could prove to be the best $0 the Trump campaign spent. Subscribe [ ](https://www.yellopolitics.com/p/why-independent-candidates-are-making) [ Why independent candidates are making independence central to their brand ](https://www.yellopolitics.com/p/why-independent-candidates-are-making) Hunter Schwarz · Oct 6 [ Read full story ](https://www.yellopolitics.com/p/why-independent-candidates-are-making) [ ](https://www.yellopolitics.com/p/these-designers-and-grocery-nerds) [ These designers and grocery nerds will brand Mamdani’s NYC grocery stores ](https://www.yellopolitics.com/p/these-designers-and-grocery-nerds) Hunter Schwarz · Oct 2 [ Read full story ](https://www.yellopolitics.com/p/these-designers-and-grocery-nerds) Trump wants to turn his first-ever golf course into a government course for presidents
WATCH LIVE: U.S. House candidates James, Mitchell debate in Iowa in race to replace Hinson
Democratic state Rep. Lindsay James and former state Rep. Joe Mitchell, the Republican candidate, are facing off in a contest to represent Iowa’s 2nd Congressional District.
Joe Rogan renews multimillion-dollar podcast deal with Spotify
Spotify announced that it has renewed its deal with Joe Rogan, who heads the audio company's most popular podcast.
Joey Lawrence says ‘Melissa & Joey’ was ‘ruined’ by Freeform
Joey Lawrence says ‘Melissa & Joey,’ in which he starred for four seasons opposite Melissa Joan Hart, was ‘ruined’ by Freeform
New ‘Menopause at Work’ project aims to protect midlife women’s health and help them thrive at work | Harvard T.H. Chan School of Public Health
Thanks to a WIN Challenge grant, the Center for Health Communication will help online influencers share evidence-based information about menopause that can prompt employers to provide more support for women workers.
LeBron James Quickly Puts Joel Embiid Rumor to Bed
LeBron James reportedly called out Joel Embiid for being late to Philadelphia 76ers practice. That report turned out to be false, as James himself shut down the rumor.
Joe Manganiello says local shaman healed him from deadly condition
In a new book, 'Bloodlines,' which drops Oct. 13, Joe Manganiello details a debilitating autoimmune disease that, he says, destroyed his marriage with Sofía Vergara and forced him to undergo 'major organ amputation.'
Joe Manganiello Reveals Health Battle That Almost Killed Him & Contributed to Sofía Vergara Divorce
True Blood star Joe Manganiello will soon release his memoir, which reveals the actor's major health crisis The post Joe Manganiello Reveals Health Battle That Almost Killed Him & Contributed to Sofía...
Iowa Business Council survey shows postive outlook on state's economy
The Iowa Business Council (IBC) has released its third quarter Economic Outlook Survey that gauges the outlook for the next six months. IBC President Joe Murphy says it’s based on a 100 point scale. “Our overall survey score was 64.91 index points, so just under 65 points, relatively flat, virtually no movement on the overall […]
Joe Manganiello opens up about near-fatal autoimmune disease battle
Joe Manganiello opened up about his health struggles, including a harrowing battle with autoimmune disease, in a new interview with People magazine.
Watch Joe Burrow's press conference ahead of Bengals vs. Dolphins
Cincinnati Bengals quarterback Joe Burrow addresses the media ahead of his team's Week 5 game against the Miami Dolphins at Hard Rock Stadium.
Joel Klatt Says Michigan’s Scheme Doesn’t Fit Its Players
Joel Klatt called Michigan's loss at Minnesota and walked away blaming something bigger than the players. #GoBlue
Joe Manganiello claims ex Sofía Vergara ridiculed him during his near-fatal health battle
Dale Jr. Compares Keselowski Split to Kyle Busch’s JGR Exit
Dale Earnhardt Jr. says Brad Keselowski's split from RFK Racing reminds him of Kyle Busch leaving Joe Gibbs Racing. He believes Keselowski should have accepted a shorter deal.
Cowboys’ Joey Porter Jr. news considered ‘good’ after Steelers trade
What's new on Porter?
Boston Celtics News: Joe Mazzulla, Players, Reflect on Summer Tour
The C's head coach visited several players in their home town.
LeBron James pushes back on viral claim involving Joel Embiid
LeBron James says not to believe everything you hear about Joel Embiid.
ESPN's Stephen A. Smith Urges Bengals to Make a Change
Frustrated by a stagnant rushing attack and Joe Burrow’s mounting burden, Stephen A. Smith demands a coaching overhaul to rescue Cincinnati’s season before the star quarterback falters.
Follow the road to Rome at 2026 Columbus Italian Festival
With its roots in Italy and heart in Columbus, the three-day Italian Festival will bring the spirit of Rome to central Ohio.
Steelers sign another cornerback
The Steelers are thin at cornerback right now with the Joey Porter Jr. trade and Jamel Dean dealing with an ankle injury.
Seahawks decide against signing Joe Mixon
After his physical, the Seahawks are not signing Joe Mixon.
Meet the former MMA fighter building his business in Prince William County
Ever the family man, Woodbridge resident and small business owner Elder Ramos, 42, attended Forest Park High School and now runs HaiJoe Stamped Concrete Patios & Decks. The company fell under the purview of the “Haijoe Property” rezoning that came before the board Sept. 1.
Oak Hill Bio Names Joerg Hipp Chief Translational Science Officer
Oak Hill Bio has appointed Joerg Hipp, PhD, chief translational science officer, bringing a former Roche neuroscience leader who previously... Read More
Joe Mixon addition further complicates Seahawks' backfield
The addition of veteran RB Joe Mixon further complicates this Seattle Seahawks' backfield.
Joe Rogan Says Money Is So Deeply Entangled In Politics That Removing It Entirely 'Seems Ridiculous To People'
Money has become such an accepted part of U.S. politics that the idea of removing it altogether sounds almost absurd, according to comedian and podcaster Joe Rogan. He argues that if the political sys...
Free agent RB Joe Mixon to join Seahawks' practice squad
The Seahawks are signing running back Joe Mixon to their practice squad.
Joe Burrow Bengals Passing Records Watch: Week 5
Heading into the 2026 season, Joe Burrow has the weight of the world on his shoulders. Can he carry the Bengals back to the playoffs after missing in each of the last three seasons? In 2023, his season was shortened due to a freak wrist injury. That injury was so severe that "experts" on Twitter …
Lawrence brothers take on missing ’90s stars in graphic novel, ‘The Lawrence Brothers Detective Agency’
Joey Lawrence and his brothers, Matthew and Andrew, take on missing ’90s stars and nostalgia prisons in the new graphic novel, ‘The Lawrence Brothers Detective Agency.’
Luke Fickell's 'vision' starting to show, Joe Thomas says
After the Wisconsin Badgers dominated Michigan State on Saturday, Hall of Famer Joe Thomas broke down the team's progress.
Lions Injury Could Force Brad Holmes Back Into Trade Market
Rock Ya-Sin’s hamstring injury could increase the Detroit Lions’ urgency to trade for a cornerback after their pursuit of Joey Porter Jr.
Virtual care firm Populus Health Technologies names Catalano as chief revenue officer
Populus Health Technologies, a virtual care media and technology company, announced the appointment of Joe Catalano as chief revenue officer.
“We’re in the entertainment business. If someone uses Suno to write a lyric, it’s not a high crime or misdemeanour”: Joe Bonamassa has sympathy for up-and-coming artists using AI to get an edge
But AI ‘artists’ shouldn’t be in the same chart as humans, he says
Morrell to join Portsmouth's coaching staff
Ex-Portsmouth and Wales midfielder Joe Morrell will be returning to his former club as a coach, joining John Mousinho's backroom staff.
Jobs in health care. Jobs for women. The US labour market is segmenting. Chernobyl’s radiation and Lenin’s love of literature.
Thank you for opening your Chartbook email. Elmer Bischoff, Two Figures at the Seashore, 1957 The only really dynamic job-creator in the US economy is health care: The largest crunch has come in Federal government, which has shed 2.7 m jobs. Source: tchouvkov on Twitter Tech is struggling. [ Joey Politano 🏳️🌈@JosephPolitano The US tech sector continues bleeding jobs in official data released today—overall, employment decreased by 17k last month and is down 69k over the last year That's nearly as bad as the worst of the 2024 tech-cession, and much worse than the 2022 boom or even pre-2020 norms 12:42 PM · Oct 2, 2026 · 15.2K Views 15 Replies · 47 Reposts · 390 Likes ](https://x.com/JosephPolitano/status/2106001807847940232?s=20) The new jobs are all for women. [ Justin Wolfers@JustinWolfers I'm not sure who saw this coming, but so far nearly all the jobs created during the second Trump administration have gone to women. 1:09 PM · Oct 2, 2026 · 33K Views 70 Replies · 146 Reposts · 644 Likes ](https://x.com/JustinWolfers/status/2106008723533533601?s=20) Meanwhile, real wages are being eaten up by modest over-target inflation. [ Heather Long@byHeatherLong The financial pain is real: Wage growth fell to 3% (y/y) in September. That's the lowest in 5 years. Wage growth: 3% Inflation: ~3.4% Inflation has eaten up all wage gains for the average worker since April. Many people are having to make hard choices about what to buy and what … 1:24 PM · Oct 2, 2026 · 37K Views 24 Replies · 275 Reposts · 533 Likes ](https://x.com/byHeatherLong/status/2106012367712620728?s=20) HEY READERS, THANK YOU for opening the Chartbook email. I hope it brightens your day. I enjoy putting out the newsletter, but tbh, what keeps this flow going is the generosity of those readers who clicked the subscription button. If you are persuaded to click, please consider the annual subscription of $60. It is both better value for you and a much better deal for me, as it involves only one credit card charge. Why feed the payments companies if we don’t have to. Subscribe Elmer Bischoff, Bathers, 1960 Americans are disillusioned with higher ed. For contributing subscribers only. Subscribe Where the Chernobyl radiation went. h/t Simon Kuestenmacher aka simongerman600 How Lenin’s love of literature shaped the Russian Revolution - Tariq Ali This, then, was the intellectual atmosphere in which Lenin came of age. His father, a highly cultured conservative, was the chief inspector of schools in his region and much respected as an educationalist. At home, Shakespeare, Goethe and Pushkin, among others, were read aloud on Sunday afternoons. It was impossible for the Ulyanov family – “Lenin” was a pseudonym adopted to outwit the tsarist secret police – to escape high culture. At high school, Lenin fell in love with Latin. His headteacher had high hopes that he might become a philologist and Latin scholar. History willed otherwise, but Lenin’s passion for Latin, and taste for the classics, never left him. He read Virgil, Ovid, Horace and Juvenal in the original, as well as Roman senatorial orations. He devoured Goethe during his two decades in exile, reading and rereading Faust many times. Lenin put his knowledge of the classics to good use in the time leading up to the October revolution of 1917. In April of that year, he broke with Russian social-democratic orthodoxy and, in a set of radical theses, called for a socialist revolution in Russia. A number of his own close comrades denounced him. In a sharp riposte, Lenin quoted Mephistopheles from Goethe’s masterwork: “Theory, my friend, is grey, but green is the eternal tree of life.” Source: The Guardian Elmer Bischoff, The River, 1953 If you’ve scrolled this far, you know you want to click: Subscribe
Yale School of Medicine On the Science of Childhood Anxiety, Say, Anxiety Disorders Are the Most Common Mental Health Challenges In Youth
Credit: Matt Bradbury October 5, 2026 - By Isabella Backman - Anxiety disorders are the most common mental health challenges in youth. Left untreated, they can disrupt the lives of both children and their families. The good news is that with intervention, most children will overcome these conditions. Across Yale School of Medicine, scientists are working to understand anxiety at every level, from common anxious behaviors to molecular biomarkers in the brain. They are using their findings to develop and disseminate new evidence-based treatments for childhood anxiety. Today, the go-to treatment for childhood anxiety disorders is cognitive behavioral therapy (CBT). This is a form of psychotherapy that teaches children skills for confronting anxious thoughts and helps them practice managing situations that cause anxiety. While it is the gold-standard treatment backed by considerable scientific evidence, up to 50% of children will not see sufficient benefit from CBT alone. Wendy Silverman, PhD, Alfred A. Messer Professor in the Child Study Center, co-directs the Anxiety and Mood Disorders Program alongside Eli Lebowitz, PhD, associate professor in the Child Study Center. One of their main interests is learning how to improve outcomes beyond CBT. “We’re developing cutting-edge, research-based knowledge that can reduce the suffering that anxiety causes children and their families,” says Silverman. Changing parent behavior YSM experts are investigating how to improve CBT outcomes for children by involving the parents. Silverman’s research has uncovered two main components of parent intervention that improve childhood anxiety: not enabling children to completely avoid the things that make them anxious and taking steps to enhance their autonomy. Parents may unintentionally reinforce their child’s anxiety by allowing them to avoid what makes them anxious. They also may unintentionally limit the children’s sense of autonomy by being overly intrusive. “One of the things that we take pride in is that we’ve focused on trying to understand what parents need to do, and to test our ideas and see if changing the parents’ behaviors is enhancing the effects of CBT,” Silverman says. “Our findings thus far suggest that they do." As much as CBT can be helpful, it can also be challenging to get one’s child to do the necessary steps for CBT to work. This is one important reason why Lebowitz created a novel intervention program for parents named Supportive Parenting for Anxious Childhood Emotions (SPACE). Existing intervention programs often teach parents to act as therapists for their child, such as training them on how to practice breathing exercises. “It makes sense, but this doesn’t work very well in practice,” says Lebowitz. “And part of the reason, I think, is that it’s not easy to get your kid to do things, especially if they’re not excited about doing it.” SPACE is unique because it focuses entirely on parent involvement and changing parental behavior—children are not involved in the sessions. For example, parents learn how to use supportive messages that convey confidence that their child can tolerate and manage distress. “It might sound like a parent saying to a child, ‘I get that this is really hard for you, but I know that you can handle it,’” Lebowitz says. The program also works with parents to identify the ways in which they are accommodating anxious behaviors. “We’ll pick one thing that parents are doing that is an accommodation and help them make a detailed plan for how they’re going to change that,” Lebowitz explains. Treating Anxiety in Children and Adolescents Much of the existing research on SPACE has focused on parents of children under age 14. Ongoing studies are now exploring its use with parents of older teens. “Both anxiety and accommodation can interfere with normative developmental shifts during the teen years, including increased autonomy and individuation from parents,” says Rebecca Etkin, PhD, associate research scientist in the Child Study Center. “In this sense, SPACE may be particularly well-suited for anxious teens and their parents. We want to see whether it is effective during this distinct developmental window.” Unfortunately, many families in need of CBT face barriers, including limited availability of services and geographic constraints. One way to improve access is digital interventions. Silverman and her team are developing an evidence-based digitized intervention program for parents that they can access directly from their computer or smart phone. “The work we’re doing will be one of the very few parent interventions that is digitized and importantly tested for effectiveness,” she says. Creating interventions for anxiety-related challenges Silverman and Lebowitz recently received a generous gift to develop and test other interventions that help parents reduce other child anxiety-related behavioral and emotional difficulties, such as restrictive eating and unexplained somatic symptoms. One of these projects in particular focuses on understanding the risks of social media and its potential benefits, including offering a sense of connection. “A lot of research has focused on the idea that social media is harmful and the less of it the better,” says Lebowitz. “But we actually see is that this is not quite right—there are negatives, but there are also positives. So, we’re trying to get a little bit more nuanced of a picture.” The team is working with teens with social anxiety and their parents over an extended period to better understand their social media habits and how their anxiety levels affect engagement with different platforms. The teens will answer questions sent to an app on their phones about mood and social media usage in an effort to capture emotional responses as they unfold. “We hope to develop interventions that can help make the best of social media while protecting against the more problematic effects,” Lebowitz says. The brain’s role in anxiety Researchers are also testing therapies to address anxiety at the neurological and molecular levels. In collaboration with Dylan Gee, PhD, professor of psychology in Yale's Faculty of Arts and Sciences, and Hilary Blumberg, MD, John and Hope Furth Professor of Psychiatric Neuroscience at Yale School of Medicine, Lebowitz and Silverman are using brain imaging to identify changes in a child’s brain before and after parents enroll in SPACE. In one study, children viewed anxiety-inducing images while undergoing magnetic resonance imaging (MRI); the researchers conducted scans with and without the children’s parents nearby. Before SPACE, children’s brains were better able to activate the regulatory circuitry needed to turn off an anxious response when their parents were nearby. But after SPACE, children could activate this circuitry even without the parent around. “As parents work on gradually reducing some of their accommodations, you can see a child get better at regulating their own fear system in the brain,” Lebowitz says. “It’s remarkable.” Research into the molecular underpinnings of anxiety can also inform new childhood anxiety treatments. In a recent study, Lebowitz, Silverman, and Flora Vaccarino, MD, Harris Professor in the Child Study Center, discovered that a protein known as fibroblast growth factor 2 (FGF2) could be protective from the toxic effects of stress. FGF2 levels in children and their parents were linked to the children’s risk of developing anxiety and depression, the study showed. The findings could help explain why some children who are exposed to early life trauma such as poverty or abuse are more prone to developing mental health disorders. And FGF2 could be a target for treatment. “This is very novel because it starts to give a clue to what is the molecular chain that connects those lived experiences to the actual psychological outcomes,” Lebowitz says. New ways to study and treat childhood anxiety Michael Crowley, PhD, associate professor in the Child Study Center, collaborates with Silverman and Lebowitz to study the role that attention plays in development and maintenance of childhood anxiety. There is a large body of research that shows that anxious children, like anxious adults, are prone to focus on threatening stimuli such as angry faces compared with neutral faces. This has led to innovative interventions that involve attention retraining. The idea is that if experts train children to look away from threatening stimuli, it may reduce their anxiety—especially children with social anxiety who are most prone to attend to threats. The researchers have just completed a clinical trial for attention retraining with 10- to 14-year-olds with social anxiety disorders and are currently analyzing the findings. Besides this innovative attention retraining research, as Crowly notes, “I like to design tasks that are engaging to kids,” Crowley says. “My goal is to assess something without the kids knowing what we are assessing.” With this goal in mind, Crowley has created a virtual game, named Boom, to study threat processing in children with anxiety disorders. The game is similar to that of hot potato—the child and three digital players take turns virtually passing a ball to each other’s gloves. At some point, the ball turns into a bomb, and as the bomb lands in each player’s glove, the outline of the glove turns yellow. The goal is to avoid having the bomb go off in your glove. What isn’t obvious is that the game is designed to measure different types of threatening stimuli, both ambiguous and direct. In the game, the direct threat occurs as the bomb is traveling towards your glove. The ambiguous threat is the yellow outlined glove as it is unknown where the bomb will travel next. While children play the game, Crowley’s team measures their brain activity using electroencephalography (EEG). The researchers have discovered that in kids with anxiety, the brain reacts more strongly to ambiguous threats than it does in their peers, but less strongly to direct threats. They believe that the initial abnormally large brain response to not knowing where the bomb is going impairs the brain's ability to properly respond when the threat is actually traveling the child’s way. “The brains of children with anxiety are unable to differentiate between threats you need to do something about and those that are not your problem.” Michael Crowley, PhD, develops innovative games for studying anxiety in children and adolescents.Credit: Matt Bradbury Based on these insights, Crowley hopes to study whether interventions like attention training could restore appropriate threat processing. Crowley’s team is also working on a test called the Balloon Risk Avoidance Task, which evaluates risk-taking and avoidance behaviors. It features a digital balloon that is full of air and about to burst. Kids have six seconds to let air out of the balloon. The more air they let out, the less risk they face that the balloon will pop. But at the same time, the balloon becomes less valuable as it deflates. “The more air you keep in the balloon, the more points you get,” Crowley explains. So far, the researchers have found that when the balloons pop unexpectedly, teens with social anxiety show distinct brain responses. Studying these responses can help psychologists understand the underlying pathways driving the various manifestations of anxiety. The genetics of anxiety When Thomas Fernandez, MD, associate professor in the Child Study Center and of psychiatry, was still in training, there was a lot of excitement about understanding the genetics associated with autism spectrum disorder. Since then, scientists have identified around 250 genes associated with autism. The genetic contribution to anxiety disorders, on the other hand, has historically received less attention. Anxiety is less heritable than autism, but the genetic contribution for anxiety disorders that emerge in childhood may be higher than for anxiety disorders overall. While scientists estimate the heritability of anxiety disorders in general to be around 30% to 50%, some studies suggest higher heritability for certain childhood-onset anxiety presentations. “I saw firsthand how researchers in the field went about finding vulnerability genes for autism,” Fernandez says. “So, we’re using a very similar playbook for childhood anxiety.” “I saw firsthand how researchers in the field went about finding vulnerability genes for autism. So, we’re using a very similar playbook for childhood anxiety.” Thomas Fernandez, MD Associate Professor In the Child Study Center and in Psychiatry Now, Fernandez and Emily Olfson, MD, PhD, assistant professor in the Child Study Center, are studying children and their parents to identify genetic changes that are present in the child but not the parents, known as “de novo mutations.” “All of us have some de novo mutations—maybe about 50 to 100 sprinkled throughout the genome,” Olfson says. “But when they occur within the coding regions of genes, they can be really disruptive.” Previous research shows that people with autism have higher rates of damaging de novo mutations than the general population. In 2022, Olfson, Lebowitz, Silverman, and Fernandez published a study on 68 children and their families that found that children with anxiety had similarly high levels of these mutations. Studying de novo mutations can help point the researchers to where they should be looking for genes associated with anxiety. “The end game is using the genes to steer us toward the right part of biology that we can then target to come up with better treatments,” Fernandez says. Building on those findings, the team is now studying more families to better understand how these de novo mutations, along with other genetic and environmental factors, shape pediatric anxiety disorders. They recently received a National Institutes of Health grant to enroll 750 new families over the next five years. Olfson is the principal investigator, with co-investigators Lebowitz, Fernandez, Silverman, and Shuangge Steven Ma, PhD, department chair and professor of biostatistics at Yale School of Public Health. Neurodevelopment, Risk Genes, and Mental Health Conditions - The Olfson Lab Joel Gelernter, MD, Foundations Fund Professor of Psychiatry, is interested in how different anxiety disorders differ genomically. “We are studying social phobia, panic disorder, and generalized anxiety disorder, working to understand why people differ in their risk to these specific anxiety disorders and evaluating various risk factors,” he says. Gelernter was recently involved in one of the largest studies to date of the genomics underlying anxiety disorder. The study included around 122,000 people with anxiety disorders and around 730,000 without. It found that some genetic differences associated with anxiety were linked to signaling that helps reduce overactivity in the nervous system. Many anxiety medications available today work by targeting this process. “It’s nice when the biology that you get out of a large genome-wide study ratifies things that we already know because that can help increase confidence in further findings from the study,” Gelernter says. Uncovering the neurobiology of psychiatric disorders John Krystal, MD, Robert L. McNeil, Jr. Professor of Translational Research and chair of the Department of Psychiatry, is interested in the neurobiology of psychiatric disorders, including post-traumatic stress disorder (PTSD), of which anxiety is a major symptom. In the late 1980s, Krystal’s team discovered that the drug yohimbine activated symptoms in patients with PTSD. “This was the first time we could link a specific biological mechanism to the symptoms of PTSD,” Krystal says. At the time, he adds, this finding was highly controversial. “A lot of people felt that PTSD was a purely psychological syndrome that didn’t have an underlying biology.” Since then, Krystal has dived deep into understanding the neurobiology of PTSD to learn how to better treat it. His team is evaluating the use of ketamine and psychedelics. These would be among the first treatments to be developed specifically for PTSD. They may also be applicable for other disorders including anxiety disorders, Krystal adds. An important gap in PTSD treatment is the absence of biological tests that inform how to best help patients manage their PTSD symptoms. A doctor doesn’t diagnose cancer based on how they feel. Rather, they use tests of the biology of the cancer to determine the best course of treatment. “And we can’t do that in any psychiatric disorder other than Alzheimer’s disease,” Krystal says. “But now we are building a foundation for this approach to the treatment of anxiety disorders for the first time.” Source: Yale School of Medicine
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