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US launches a review of Mexican consulates that could lead to closures
The Trump administration is conducting a review of the 53 Mexican consulates in the United States | KMBZ
Mexico in Numbers: Women's representation in politics
Mexico in Numbers: Mexican women in politics now hold 50% of cabinet seats, lead 44% of states and are a majority in the Chamber of Deputies.
Recruiting healthcare workers to New Mexico a top priority at candidates forum
Gubernatorial and lieutenant gubernatorial hopefuls gathered for a panel hosted by the New Mexico Alliance of Health Councils.
Canceled Cinco de Mayo parade impacts Little Village businesses for second year in a row
Business owners say the canceled Cinco de Mayo parade dampens what is typically a time to celebrate Mexican culture in neighborhoods like theirs.
This iconic L.A. Mexican restaurant is celebrating 70 years in business with a special honor
Iconic Mexican restaurant Casa Vega was given a special honor on Tuesday as the Sherman Oaks staple celebrates 70 years in business. A ceremony was held to commemorate the naming of the intersectio…
Kimberly Goes to Business School No. 3: When the tool isn't the system
A workflow problem is remedied by a simple shift, persuading caregivers to use an AI tool they previously had ignored.
St. Michael's Horsemen again land dreaded top-4 baseball seed
To break a mold that has only brought them heartache for more than five years, the Horsemen will have to do something in the state tournament they haven’t done since
David Benavidez calls out Canelo Alvarez after destroying Gilberto 'Zurdo' Ramirez to capture the WBA and WBO cruiserweight titles
David Benavidez batters Gilberto Zurdo Ramirez en route to becoming the new WBA and WBO cruiserweight champion; Ramirez was down in the fourth and then again in the sixth when he took a knee and was forced to succumb to The Mexican Monster
Decoding boys, girls playoff scenarios
As usual, there is plenty of confusion over how the playoffs work.
LIVE! Watch ‘Benavidez vs. Zurdo’ Prelims For Free
Before David Benavidez challenges WBO and WBA Cruiserweight champion, Gilberto “Zurdo” Ramirez, for his WBA title later TONIGHT (Sat., May 2, 2026) inside T-Mobile Arena in Las Vegas, Nevada on DAZN PPV, you can check out some of the early “prelims” for free on YouTube. “The Mexican Monster” and “Zurdo” will also be competing for […]
Chicago's Tuco & Blondie celebrates 10 years in business
One Chicago Mexican restaurant not only has Cinco de Mayo to celebrate this month, but also 10 years in business!
Santa Fe County sheriff candidates divide on behavioral health solutions
Former police chief Paul Joye has advocated for an alternative response model in Santa Fe County; his opponents have expressed doubts.
Santa Fe proclaims National Small Business Week, Jewish American Heritage Month
Mayor Michael Garcia described small business as "the backbone" of our community at a City Hall event on Friday.
Video: ‘Mexican Monster’ Stares Down Zurdo In ‘Sin City’
David Benavidez (31-0) will make his much-anticipated return to the ring this Saturday (May 2, 2026) to face off against one of the biggest challenges of his career when he goes toe-to-toe against WBA (Super) and WBO Cruiserweight champion, Gilberto “Zurdo” Ramirez (48-1), inside T-Mobile Arena in Las Vegas, Nevada. For Benavidez, it’s his chance […]
Downtown eatery owners purchase Santa Fe landmark El Farol
Closed since last fall, the Canyon Road restaurant has been purchased by Palacio Cafe owners Damien Muñoz and Maria Vigil.
Rebecca Solnit talks politics, new book, Santa Fe International Literary Festival appearance
Best-selling author and activist Rebecca Solnit joins "Conversations Different" to discuss her new book, politics and her appearance at the Santa Fe International Literary Festival.
Trump administration to target corruption in Mexico
U.S. Ambassador Johnson signals a Trump administration anti-corruption campaign targeting Mexican officials allegedly linked to organized crime.
Ms. Rivera goes to Washington — to advocate for liver health
Through years of monitoring, a cancer diagnosis and two liver transplants, Rivera found a passion for liver health advocacy.
The secret is out: New Mexico chef wins Food Network's 'Chopped'
Navajo chef Justin Pioche of Fruitland was also a finalist for Best Chef: Southwest in the 2023 James Beard Awards.
CBL Scholars Program Opens Pathways to Business Law Careers - UC Law San Francisco (Formerly UC Hastings)
First-year law students and 2026 CBL Scholars Deniz Masjedi, Alvaro Flores, and Tavia Pappaly gain mentorship connections with leading industry professionals as they prepare for careers in business law. Created by the UC Center for Business Law San Francisco (CBL), the CBL Scholars Program aims to develop the next generation of business law leaders, supported by contributions from individuals and corporate sponsors. The highly competitive program provides funding along with academic and professional mentorship to students from disadvantaged backgrounds. Scholars gain exposure to the Bay Area’s technology and venture capital ecosystems and access to UC Law SF’s broad network of senior legal professionals. Now in its sixth year, the CBL Scholars Program provides a scholarship and academic and professional mentorship to students entering the business law community from disadvantaged educational, economic, social, or physical backgrounds. The program is generously sponsored by the law firms Gunderson Dettmer and Goodwin Procter. Meet this year’s CBL Scholars: Deniz Masjedi, Alvaro Flores, and Tavia Pappaly. All three have secured summer associate positions at prestigious law firms. Deniz Masjedi: A Passion for Helping Founders Grow Companies Deniz Masjedi, who was born in Iran and moved to Southern California as a teenager, traces her interest in law to her family’s immigration journey and her desire to advocate for herself and her family. She earned a bachelor’s degree at UC Berkeley, where she studied political science and sociology. At UC Law SF, she serves as a 1L representative for the Iranian Law Students Association and is active in the Business Law Society and Technology & Law Society. Next fall, she will serve as director of mentorship for the Technology & Law Society and director of professional development for the Business Law Society. She will join Sidley Austin this year as a 1L/2L summer associate. Q: What draws you to business law? A: Prior to law school, I worked in Cooley LLP’s Private Companies practice group as a corporate paralegal for three years, supporting over 100 venture-backed startups and venture capital funds. I found purpose in helping founders transform their vision into successful companies. It was incredibly rewarding being part of their journeys—from company formation and initial financing to major transactions such as M&A deals. What excites me most about this field is the potential for a small, innovative company to become the next Google or Zoom, shaping how people communicate and access information. I hope to continue supporting entrepreneurs and investors as a corporate attorney. Q: What does it mean to you to have been awarded this scholarship? A: As the first person in my family to attend law school in the United States, receiving this scholarship is a tremendous honor. My parents and I left everything behind so that I could enjoy the freedom to practice my religion without persecution and pursue a career in law as a woman. This award is an acknowledgment of my dedication to business law and motivates me to continue pursuing excellence in this field. It also recognizes years of hard work—learning a new language, navigating the college and law school application process, and ultimately building a career in the legal profession. Q: How will this scholarship help support your future goals? A: This scholarship will provide access to mentorship from leaders in the field, enabling me to develop the skills necessary to offer practical advice and effective representation to future clients. It also eases the financial burden of law school, letting me focus on my coursework and deepen my commitment to corporate law. As an immigrant, breaking into the legal profession has not always been easy, and the time that mentors have invested in me has been instrumental to my progress. This scholarship will allow me to continue building those relationships while positioning me to one day mentor others pursuing similar paths. Alvaro Flores: Inspired by Entrepreneurs The son of Mexican immigrants raised in San Antonio, Texas, Alvaro Flores says he has long been interested in how policy, markets, and culture shape society. He studied international relations and global economy at the University of Southern California, with minors in business finance and legal studies. His experiences span local political organizing, venture capital and startup work, and teaching entrepreneurship. At UC Law SF, he is involved in the Business Law Society, Technology & Law Society, and the Latinx Law Student Association. He will join Perkins Coie as a 1L/2L summer associate with the firm’s Emerging Companies & Venture Capital practice. Q: What draws you to business law? A: I’m drawn to stories of entrepreneurs whose simple ideas become companies that shape the economy and society. Spending time in venture capital and working directly with founders has shown me that many important decisions in the scaling process are ultimately legal ones, particularly how companies are structured and how capital is raised. Business law sits at the intersection of innovation and equity. It offers a way to stay close to the pace of technological change while also helping expand who gets to participate in it. There is something special about being part of that process here in the Bay Area, where the American Dream feels like it is reimagined in real time. Q: What does it mean to you to have been awarded this scholarship? A: I am truly grateful for the support and belief this scholarship represents. I see it not just as recognition, but also as alignment. The CBL Scholars Program’s focus on developing individuals who engage deeply with the business and technology ecosystem reflects the path I have been intentionally building. More than anything, it feels like an investment in that journey. I have been thoughtful about each next step–whether teaching, working in venture capital, or building multidisciplinary experiences–and this scholarship reinforces that those efforts come together in a meaningful way. Q: How will this scholarship help support your future goals? A: It allows me to focus more on developing as a business lawyer, without the distraction of financial constraints. Beyond that, the mentorship and access to the Bay Area network are just as valuable. I’m especially interested in working with early-stage companies and investors, so the opportunity to learn directly from people operating at a high level in that space is huge. Tavia Pappaly: Working in the Wine Industry Sparked Interest in Business and Law Tavia Pappaly spent five years in the wine industry before deciding to pursue law school with a goal of becoming a corporate transactions attorney. Pappaly says she wants to use her legal skills to help business grow and thrive. A first-generation law student from Fairfield, California, she is a member of the Legal Education Opportunity Program (LEOP) and will serve as vice president of social planning for the UC Law SF Sports Law Society in her 2L year. She plans to work as a summer associate at Gibson Dunn in San Francisco after her 2L year. Q: What draws you to business law? A: Business law brings together many of my interests and personal experiences. As the daughter of immigrants who grew up around a family-owned small business, I saw firsthand both the opportunities and challenges of building something from the ground up. That perspective, combined with my experience in the wine industry, solidified my interest in helping businesses of all sizes tackle evolving legal challenges. I’m excited to grow within the corporate law space and develop the skills and experience to support businesses at every stage. I’m deeply motivated to give back to immigrant communities and small business owners, whose experiences often intersect. By building a strong foundation in corporate law, I hope to support those working to create generational stability and to contribute in a meaningful way to the communities that have shaped me. Q: What does it mean to you to have been awarded this scholarship? A: Receiving this scholarship is incredibly meaningful to me. I take great pride in my background as a first-generation student and a woman of color, so being recognized for my potential in a field that has historically underrepresented those communities is both affirming and empowering. This program will help connect me to the resources and committed mentors that will help me succeed. Beyond that, it is no secret that law school is a significant financial commitment. This scholarship helps ease both the financial burden and the stress that comes with it, allowing me to focus more on my education and long-term goals. I am incredibly grateful! Q: How will this scholarship help support your future goals? A: This scholarship has already connected me with an incredible network of faculty, business law professionals, and like-minded students. The community fostered by the Center for Business Law is deeply supportive, and I’m excited to grow alongside my cohort. I truly believe this network will play an important role in helping me thrive in law school and position me for success in business law. As I have seen firsthand how impactful both financial scholarship and mentorship are, I hope to give back in this same way later in my career.
Americans killed in Mexico car crash following drug raid worked for the CIA, sources say
The two US embassy officials who died in a car accident in Mexico on Sunday worked for the CIA and had been collaborating with Mexican officials on expanded counternarcotics operations in the country, two people briefed on the matter confirmed to CNN.
Gas prices down last week in Santa Fe, across New Mexico
While prices remain high, the cost of fuel throughout New Mexico and the Santa Fe area declined last week, according to Thursday's AAA New Mexico Weekend Gas Watch.
Two New Mexico Indigenous chefs to appear Tuesday on Food Network's 'Chopped'
Two Indigenous New Mexico chefs who will be appearing on Chopped say they hope the program helps promote the Native food movement.
Santa Fe's newest theater, EVO Entertainment, offers more reasons to go back to the movies
As streaming services have flooded our homes with entertainment options, the thought of watching movies on the big screen has become increasingly rare. The numbers agree: In 2025, the domestic
Why thousands of 2026 entertainment season workers are one accident away from financial disaster
Thimble reports that gig workers in the 2026 entertainment season face financial risk from accidents due to insufficient insurance coverage.
Tech businesses express optimism as report predicts continued New Mexico growth
The State of the Tech Workforce 2026 report ranks New Mexico 38th nationally with a tech labor force of more than 97,000 workers.
New Mexico childhood obesity up as Trump administration cuts erode healthy food programs
By third grade, New Mexico childhood obesity rates outpace the national average — which hovers around 20% for those 2 to 19.
New computer science in art degree brings worlds together at Santa Fe's IAIA
IAIA's new computer science program brings new degree offerings and a digital renaissance across the campus' disciplines.
Food hall vendors outline plans for downtown Santa Fe venture
The new Santa Fe food hall at 150 Washington Ave. will feature 17 vendors — 11 eateries and six beverage enterprises.
Where will diners park at downtown food hall?
Developer Jim Long of Heritage Real Estate Co. says there should be plenty of parking options, with nearby garages and metered parking.
Diggins signs with the Sky; Sabally joins Liberty
Skylar Diggins is headed to Chicago while Satou Sabally is coming to New York as WNBA free agents can officially sign Saturday. Diggins spent the past two seasons with the
Santa Fe business owners, residents sound off south-side homeless shelter plans
The new shelter will be operated by Interfaith Community Shelter on a 1.1-acre plot of land near Santa Fe Place mall.
Pittsfield Health Shuts Down North Street Eatery for 'Pests'
Closed sign on Iztac's front door. PITTSFIELD, Mass. — Iztac Mexican Restaurant is currently shut down by the Health Department. A hearing at the Board of...
Are DVDs poised for a comeback? In Santa Fe, they never left
Some local store owners have noticed a growing preference for physical media among some Gen Z and millennial customers.
Kimberly Goes to Business School, part 2: Supporting the work
"Kimberly Goes to Business School" continues, with an experiment with a new scheduling model teaching the limits of AI.
Business People: Sen. Luján given James Beard award for legislative work
Luján was honored for leading Senate Democrats in introducing legislation to prevent food aid from being withheld during the shutdown.
Lawmakers spent big to give New Mexico health care system shot in the arm
Legislators directed hundreds of millions to a new medical school facility, expansion of rural residencies and faculty raises.
Art and politics … intersecting again
The stunning ”Resistance” Mexican art exhibit at the New Bedford Art Museum is unpredictable and necessary.
Low and slow meets forever: US postage stamps honor lowrider car culture
NEW MEXICO Stamps honor lowrider culture ALBUQUERQUE — From Mexican American and Chicano barrios in the American Southwest to the halls of the Smithsonian on the National Mall and even the streets of Japan, lowrider culture has become part of mainstream car culture around the globe. The U.S. Postal Service is joining the club with […]
New Mexico's court-mandated pathways to mental health care
Lawmakers have made changes in recent years to bolster the treatment system, but advocates say wide gaps render them insufficient.
Manuel's El Burrito in Clearfield marks 50 years in business; operators hope for 50 more
Manuel's El Burrito in Clearfield held a small celebration on Tuesday to mark 50 years in business, making it among Utah's longest-lasting Mexican restaurants.
Staley eyes another title as South Carolina meets UCLA
A win over UCLA would tie Staley for the third most titles by a coach/ The Bruins haven't won a national title since 1978.
Annual Santa Fe Chamber of Commerce Business Expo planned for Thursday
Roughly 120 exhibitors and more than 1,000 attendees are expected for the expo at the Santa Fe Community Convention Center.
New Mexico Museum of Natural History and Science Reopens April 4 with Traveling Exhibition
"Animal Armor: The Evolution of Armor in Dinosaurs and Prehistoric Animals" puts the spotlight on armored animals and the history of the evolution of armor in prehistoric creatures.
New Mexico Wellness Wire: Health officials warn against baby birds as Easter gifts
Salmonella infections often occur after consuming contaminated food or water or touching animals, their waste or places they live.
New Mexico Museum of Natural History and Science to reopen after monthslong revamp
The museum's $3.7 million renovation includes a new sewer line, fresh skylights and the latest in scientific knowledge.
Are insurance premiums tax-deductible? How to write off business insurance
ERGO NEXT reports that business insurance premiums can be tax-deductible, depending on their classification by the IRS.
Coca-Cola’s yellow caps are back — what they mean and why they’re compared to Mexican Coke
Coca-Cola bottles with yellow caps are appearing on shelves across the U.S., as they do every spring around Passover, and social media is taking notice.
UFC brings cage-match bout to White House, home of a president who favors cage-match politics
Trump has boasted that the June 14 event feature “all top guys.” But fans online have panned the White House fight card as underwhelming.
Program aims to help Santa Fe businesses hit by crime
The program has $210,000 in funding, and the money will be awarded to businesses until the funds run out.
Mexican hotspot ‘Canta Corazon’ brings entertainment, unique drinks to Wynwood - WSVN 7News | Miami News, Weather, Sports
Deco people are the kind of people looking to turn a regular night out into something way more fun. Good thing Wynwood’s got a newRead More
Mexico's Karim Lopez reportedly declares for the 2026 NBA Draft
Lopez could become the first player of Mexican descent selected in the first round.
Your Thymus and Your Healthspan
Our thymus gland plays a central role in the development or our immune system, specifically for supporting T cell development (how these cells got their name, maturation and differentiation in the thymus) and discriminating between self and foreign, non-self antigen proteins with production of dendritic cells. As we age, our thymus gland shrinks—the process known as involution—with progressive change from spongy to fatty tissue, with loss of functionality. But this process, with respect to timeline and extent, markedly varies from one person to the next. And to make things even more complicated, our thymus gland anatomy and precise location in the chest also is highly variable. So the famous Frank Netter diagrams from the 1960s (such as at left below) don’t capture the remarkable heterogeneity that a random set of 12 chest CT scans (below at right). What I consider as 2 landmark papers in Nature this week (here and here) used AI to quantify health of the thymus in 2 large cohorts, and then correlate the metric to a broad array of health outcomes. In this edition of Ground Truths, I’m going to cover three questions: (1) How was thymus health determined by AI?; (2) How is thymus health linked to key clinical outcomes? and (3) Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? Subscribe 1. How was thymus health determined by AI? This was accomplished by extensive work developing and validating an AI pipeline for 2 stages, the first for localization and segmentation of the thymus bed, and the second to quantify a digital marker, termed the thymic health score. There’s a lot to this algorithmic development, so I won’t go into all the details, but just provide a rudimentary outline of what was done. The 1st stage used supervised learning with 2 radiologists reviewing 2,461 chest CT scans. That work trained a 3D U-Net model to automatically identify the thymic bed’s 3D cropped region using center of mass coordinates, which reached 99.8% accuracy. The 2nd stage used a foundation model that was pre-trained with SwAV (which stands for Swapping Assignment between multiple Views), a self-supervised model, that generated a high-dimensional thymus representation of 4,096 features. That compares to the radiology reductionist and subjective scoring of 0 to 3 where 0 means the thymus is fully degenerated and fatty, and 3 is considered dense, intact glandular soft tissue. Notably, the self-supervised learning (SSL) performance was superior to supervised (AUC ~0.75 vs 0.55, respectively) reflecting the shallowness of the 0-3 classifier vs SSL’s holistic, self-taught AI. The thymic health score ranged from 0 to 100, with the highest number indexed to fully preserved thymic health. The algorithmic work extended to explainability with both Shapely value distribution, meaning the model was holistic not relying on any “magic” pixel, and occlusion sensitivity, demonstrating the model’s performance was not affected by ribs, sternum, lung tissue, but rather focused on the thymic bed directly. Below are a few saliency maps from the occlusion sensitivity that indicate the thymic bed focus, not affected by neighboring structures, using the jet color scale. Now the AI was ready for processing ~25,000 CT scans, each over 30 MB files, from the 2 large participant cohorts to provide a thymic health score, it did so in less than 14 hours, which is less than 2 seconds per scan! Share 2. How is thymus health linked to key clinical outcomes? The two cohorts were the National Lung Screening Trial, NLST (N=25,031) and the Framingham Heart Study, FHS (N=2,581) each with baseline demographics and long term follow up of >12 years for health outcomes. From the NSLT, you can see below that increased age and body-mass index were correlated to reduced thymic health. And, overall, men had reduced thymic health scores compared with women. There are a lot of graphs in the paper for outcomes, for both the NLST and FHS cohorts. To simplify the major outcomes, below is a composite Figure with striking reduction of all-cause mortality and for the different causes of death. The results were consistent between the 2 cohorts. For example, the cardiovascular mortality hazard ratio average was 0.57 in NLST and 0.38 in FHS (weighted to be 0.53 for the aggregate). The reduction of mortality also extended to digestive diseases and pulmonary disease (data not shown below). Lung cancer incidence was reduced by 36% for high vs low thymic health (Figure below, with a panel -incidence and b panel-mortality, adjusted for age, sex, BMI, smoking status). Notably, there was a smoker’s paradox: lower incidence and improved survival for lung cancer in smokers who had a high thymus health score. Smoking was associated with lower thymic scores whereas alcohol was not. Higher thymic health was linked to higher HDL cholesterol, lower triglycerides, lower fasting blood glucose, and lower systolic and diastolic blood pressure. Inflammation biomarkers, such as C-reactive protein and interleukin-6, were elevated in the people with lower thymic health scores. In their second paper, the same team looked at the relationship between thymic score and outcomes for 3,476 patients receiving cancer immunotherapy. The non-small cell lung cancer progression-free survival was reduced in patients with low thymic health score. A parallel relationship for survival was seen for other types of cancer including melanoma, breast, and kidney with a 44% lower risk among high thymic scores (Figure). A similar pattern was seen with different immune checkpoint inhibitors. The thymus health score outperformed programmed death ligand-1 (PD-L1)and tumor mutation burden (TMB) assay of the tumor and was an independent prognostic marker of progression-free survival. In this dataset, a direct connect with thymus score and adaptive immune function was noted with a correlation before cancer treatment for both T-cell diversity and thymus T-cell production (a metric known as T cell receptor excision circles). Thymus Removal Study There is a highly relevant citation about thymus function before moving onto ways to rejuvenate it. In 2023, a very important study of thymus removal during cardiothoracic surgery was published, with 1146 patients undergoing thymus removal vs 1146 matched controls (mean age 55 years). The adverse outcomes for thymus removal were striking, with a 2.9 higher risk of all-cause mortality and doubling of cancer incidence, 1.5 fold increase in cancer mortality, and 1.5-fold increase in autoimmune diseases. The immune function showed marked compromise after thymus removal, as reflected by CD4+ and CD8+ T cells (Figure below) Share Ground Truths 3. Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? In recent months we’ve learned a lot about the process of thymus involution and the pathways by which this may be modulated. Thymus involution is primarily due to loss to thymus epithelial cells (TECs) and there are 2 subtypes with different functions: the cortical, responsible for positive selection of T cells, and the medullary, for negative selection. When adipose tissue infiltrates the thymus, thymic adipocytes are pro-inflammatory, knocking out T-cell output. Likewise, systemic inflammation, or “inflammaging,” from smoking, obesity, and chronic stress promote thymic adipocytes. Now, from preclinical studies, we know about key pathways that account for these processes. Historically, back in 2014, FOXN1 was recognized as a single master transcription factor essential for TEC function, with studies in mice with forced FOXN1 upregulation leading to thymus regeneration. That laid the foundation for potential regrowth of quiescent thymus cells. It took awhile to find pathways to accomplish this goal and to even refute its role as the master regulator. The Liver-Thymus Axis Feng Zhang and his team recently showed that injection of an mRNA vaccine to the liver encoding DLL1, IL-7 and FLT3-L in combination, factors known to support thymopoiesis (Figure), successfully enhanced immune function in aged mice. However, the effect was transient. The FGF21 Story Two reports in 2025 addressed the thymus gland’s production of FGF21, a growth factor (fibroblast growth factor 21) and its control of thymus involution. This growth factor is also produced by the liver, but it doesn’t have impact on the thymus in aged rodent models. In contrast, The liver’s hepatocyte growth factor (HGF) has been shown to reverse senescent TEC structural changes. Growth hormone stimulates production of insulin growth factor-1 (IGF-1) in the liver and the thymus. Two small studies in human participants (TRIIM, for Thymus Regeneration, Immunorestoration, and Insulin Mitigation) of 6 and 50 people, respectively, treated with combined human growth hormone, metformin and DHEA, suggested the potential of slowing epigenetic aging and improving thymus mass and function. But the combination of drugs, small sample, and lack of controls make conclusions murky. Increased thymus FGF21 led to increased CD8 T cells in old mice and extended healthspan and improved physical performance. Building on the previous FOXN1 data, ablation of β-klotho, the obligatory co-receptor for FOXN1, accelerated thymic aging. The benefit to FGF21 was confirmed in a companion paper using an FGF21 knock-in mouse model showing thymus enlargement and increased TECs throughout the lifespan. (schematic Figure below). The accompanying editorial for these 2 papers speculated: “The proposed link between age-associated thymus involution and organismal aging is intriguing, and suggests we might seek to achieve systemic rejuvenation by counteracting thymic involution.” Other Factors Lessons from the Axolotl (Mexican Salamander) In an elegant set of experiments of the axolotl (Figure), known for its complete thymus regeneration after total surgical removal, mediators were identified. Surprisingly FOXN1 was dispensable. But midkine, a growth factor, appeared to be the driver, the initiator of thymus cell growth, survival, and repair. Other components that contributed were Postn+ (periostin-expressing mesenchymal niches) and Ccl19, a chemokine protein from the bloodstream. RANK and RANKL RANK (receptor activator of nuclear factor κB its ligand (RANKL) have been considered key regulators of medullary TECs. In a study of both aged mice and human thymus cell cultures, their key role was confirmed, with multiple benefits of resorting TEC function, recruitment of progenitor cells, and T cell development. Subscribe Summing Up This body of work strongly supports the health of the thymus gland as a critical regulator of human healthspan, not just a correlate or link. The new landmark studies are reinforced by the regenerative biology experimental models that have shown, via an array of mediators, that healthspan of aged mice is at least in part dependent on thymus gland function and its critical role for maintaining adaptive immunity. It sure seems that we’d be better off having an immune reservoir of naive T cells instead of a profile in older adults of exhausted, low quality, memory T cells, with a senescent phenotype. It is striking that we ignored the importance of the thymus gland for many decades. A wake-up call was the results of the thymectomy matched control study reviewed here, with the opposite of high thymic health score improved health outcomes. The convergence of AI and healthspan here is notable. The exceptional and laborious work for developing and validating (no less explaining) the AI to quantify thymus health set the foundation for probing the connect the major health outcomes in two cohorts with extensive follow-up. We’ve never had a way to meaningfully quantify the thymus gland before, so this represents important leverage of supervised, self-supervised, and transformer models. The study wouldn’t have been possible without AI. And it begs the question as to whether there are ways we can maintain our thymus at a high health score. But it’s not so simple to rejuvenate our thymus. There are multiple risks including the induction of autoimmunity, increasing the risk of cancer, and inducing a pro-inflammatory state. For example, factors that increase TEC proliferation could compromise the medulllary negative selection process and leak out auto-reactive (self-attacking) T cells. Thymic cells could be induced to proliferate, but we know, for example, that growth hormone and IGF-1 are associated with an increase risk of cancer. If thymus rejuvenation doesn’t clear out the accumulated senescent cells in older adults, then inflammation within the gland could block the production of TECs. Keeping these risks in mind, we now have identified many ways to keep our thymus healthy as we age that undoubtedly will be tested in clinical trials going forward. Ultimately, the benefit-to-risk tradeoffs will be defined. In the meantime, we have desperately needed an immunome. As I’ve stressed in multiple prior Ground Truths, we have no test in the clinic to assess a patient’s immune status! It was very encouraging for me to get an email from Hugo Aerts, the senior author of the landmark papers in the days after they were published: “I also wanted to say that your Substack on “Why We Need an Immunome” was inspiring for this work. We found it a very compelling perspective and greatly enjoyed reading it.” Just having an assessment of a person’s immune status via a chest CT scan, with millions of these performed per year, might help in guiding the right immunotherapy for cancer (e.g. more intensive, combinations for those with low thymic health scores) and help define people who are increased risk for age-related diseases of cancer, cardiovascular, and neurodegenerative. The main theme of Super Agers is that we now have many layers of data (genetics, proteins, biomarkers, organ clocks that can be integrated via multimodal AI) for us to define a person’s specific risk decades before one of these age-related diseases leads to symptoms, enabling prevention. From the new studies this week, we can add thymus health score as yet another way to understand a person’s risk, a window into their adaptive immune system and healthspan. And perhaps someday we will be able to safely rejuvenate the thymus, or maintain its health through one’s life, and use the thymus health score to monitor. NB: I wrote this post (No A.I.) A Quick Poll Loading... ********************************************************************* Thanks to Ground Truths subscribers (now > 200,000) from every US state and 212 countries. Your subscription to these free essays and podcasts makes my work in putting them together worthwhile. Please join! If you found this interesting PLEASE share it! Share Ground Truths Paid subscriptions are voluntary and all proceeds from them go to support Scripps Research. They do allow for posting comments and questions, which I do my best to respond to. Please don’t hesitate to post comments and give me feedback. Let me know topics that you would like to see covered. Leave a comment Many thanks to those who have contributed—they have greatly helped fund our summer internship programs for the past two years. It enabled us to accept and support 47 summer interns in 2025! We aim to accept even more of the several thousand who will apply for summer 2026.
Santa Fe small businesses awarded microgrants to pursue new opportunities
A total of 40 Santa Fe business owners received the microgrants, which were valued at between $3,000 and $5,000.
Paseo Pottery to launch Pitch Night to help Santa Fe nonprofits
The event will have a Shark Tank-like atmosphere, except participants will compete for the right to a pottery fundraiser.
Health Department: Santa Fe County patient contracts, recovers from hantavirus
Hantavirus pulmonary syndrome, in which flu-like symptoms progress to trouble breathing, is fatal in about 40% of cases.
Chain favorite replacing Wawa at Trexler Business Center in Lower Macungie
Qdoba Mexican Eats is launching its third location in the Lehigh Valley, operating by the same group running the Whitehall and Westgate Mall sites.
🚨 Marcel Ruiz injury sparks concern for the national team
It’s been a complicated week inside the Mexican National Team, as in addition to the loss of Luis Ángel Malagón, Marcel Ruiz has raised concerns after leaving the field at the Snapdragon Stadium....
West El Paso steakhouse receives low health inspection score: See list
A West El Paso Mexican steakhouse received a barely passing score in this week's restaurant inspections.
San Antonio entrepreneur turns story, chorizo into thriving business
Maria Flores, a Mexican-born entrepreneur, replicated the flavor of her grandmother's chorizo and placed it in jars. It's now sold at H-E-B.
Tijuana truckers say English requirement is putting them out of business
Mexican truck drivers, including some with decades of experience, say they are facing difficulties when tested for English proficiency.
Mexican Billionaire Builds Next Banking Bet After Citi Deal
After reaching a $2.3 billion deal to buy a stake in Banamex, Fernando Chico Pardo plots out the path for the Mexican banking business.
🚨 Mexico’s starting XI for the friendly against Iceland
Everything is ready in Querétaro for the Tricolor to continue its preparation journey towards the 2026 World Cup. The Mexican territory has been in the eye of the storm due to the violent events that...
Citi nears Banamex stake sale to investor group including Blackstone, Bloomberg News reports
Citigroup is nearing a deal to sell a 24% stake in its Mexican retail bank Grupo Financiero Banamex to a group of investors that includes Blackstone , Bloomberg News reported on Monday, citing people familiar with the matter.
Scientists Find When to Stop Eating Before Bed to Boost Heart Health
Dietitians and a doctor break it down.
MFL 3: Gable Steveson vs. Hugo Lezama LIVE stream
Follow along live for Gable Steveson’s third MMA fight at Mexican Fight League 3
Kimberly Goes to Business School, No. 1: Designing the Experiment
The business schools at Harvard and Tulane universities are conducting a field study of Biscochito's move to collaborative scheduling, via AI.
'An alarm bell': Los Alamos Visiting Nurse Service shutters amid turmoil for home health care
The closure should serve as a warning for the industry and policymakers, said the leader of a home and hospice care association.
Gov. Lujan Grisham named to 2026 TIME100 Health list
Lujan Grisham joins federal health care officials, pharmaceutical CEOs, scientists, researchers, actors and performers on the list.
Gov. Michelle Lujan Grisham named on the 2026 TIME100 Health list
Lujan Grisham joins federal health care officials, pharmaceutical CEOs, scientists, researchers, actors and performers on the list.
Measles outbreak in Mexico prompts health alert in World Cup host Jalisco
ZAPOPAN, Mexico (AP) — The Mexican state of Jalisco on Thursday issued a health alert and mandated the use of face masks in schools as a measles outbreak hit the state capital, a key host city for the…
Measles outbreak in Mexico prompts health alert in World Cup host Jalisco
The Mexican state of Jalisco has issued a health alert and mandated face masks in schools due to a measles outbreak in the state capital
New Mexico solar firms hope tax credit hike will help boost business
With the expiration of a federal tax credit, installation companies are feeling the strain. Customers are relying more heavily on state aid.
Mexico Buy Now Pay Later Business and Investment Report 2026: A $13.85 Billion Market by 2031 from $3.98 Billion in 2025 Featuring Kueski, Mercado Pago, Aplazo, Nelo, and Atrato
The BNPL market in Mexico and South Korea offers robust growth prospects. Key opportunities lie in diverse retail and e-commerce sectors, driven by consumer trends and innovative business models. Understanding consumer behavior and leveraging a variety of distribution channels remain critical for market expansion. Mexican Buy Now Pay Later Market Mexican Buy Now Pay Later Market Dublin, Feb. 04, 2026 (GLOBE NEWSWIRE) -- The "Mexico Buy Now Pay Later Business and Investment Opportunities Databook
Students’ skills and interest in science tumble in first post-COVID-19 test
The 74 reports that U.S. eighth graders' science skills and interest have declined post-COVID, with proficiency falling from 33% to 29%.
Aurora restaurant concerned new city construction project may hurt nearby businesses
Casa Vallarta Mexican Restaurant in Aurora has survived a lot of trials since it opened its doors in 1998. It is now preparing for yet another challenge as a major construction project is set to begin nearby.
Santa Fe businesses to close Friday as part of nationwide anti-ICE protest
The Santa Fe closures are part of a national effort to convey dissatisfaction with recent actions of ICE officers in Minneapolis.
Feds OK New Mexico's $382 million broadband expansion plan for homes, businesses
The funding is slated to serve more than 42,000 unserved and underserved homes and businesses across the state.
Goldgroup Announces Business Combination with Gold Resource Corporation to Create a New, Mexican-Focused Precious Metals Producer
Vancouver, British Columbia--(Newsfile Corp. - January 26, 2026) - Goldgroup Mining Inc. (TSXV: GGA) (OTCQX: GGAZF) ("Goldgroup" or the "Company") is pleased to announce that it has entered into a definitive arrangement agreement and plan of merger (the "Arrangement Agreement") with Gold Resource Corporation (NYSE American: GORO) ("GRC"), whereby Goldgroup has agreed to acquire all of the issued and outstanding shares of GRC's common stock (the "Transaction").Transaction DetailsPursuant to the..
New Mexico law has triggered review of two health care mergers since 2024
Lawmakers and advocates argue the law still has loopholes allowing some private equity transactions to avoid scrutiny.
Saginaw family turns children’s pretend food truck into thriving taco business
The family-run business started out serving only their beloved tamales. Sis-N-Bros Tacos has since morphed into food truck and a vendor at SVRC Marketplace with an expanded menu of Mexican favorites.
EVO Entertainment cinema at San Isidro Plaza opens Friday after long delay
Santa Fe's newest theater, the EVO Entertainment cinema, opens Friday evening and features two large-format auditoriums.
Peanuts and politics; plus, do we need a lieutenant governor?
Opening day of the legislative session nearly wasn't as entertaining as the marching band from Eastern New Mexico University.
Mexican Marvel: how an international business got a much-needed health boost with flexible, scalable fulfillment
A leading wellness company transitioned from an outdated, underperforming supply chain to a professional, future-ready, digital logistics solution cutting logistics costs by 30%.
ICE agents detain workers at Mexican restaurant after visiting business for lunch
Arrests by ICE agents in the greater Minneapolis area have closed restaurants and left communities on edge.
ICE agents detain workers at Mexican restaurant after visiting business for lunch
Arrests by ICE agents in the greater Minneapolis area have closed restaurants and left communities on edge.
ICE agents detain workers at Mexican restaurant after visiting business for lunch
Arrests by ICE agents in the greater Minneapolis area have closed restaurants and left communities on edge.
ICE agents detain workers at Mexican restaurant after visiting business for lunch
Arrests by ICE agents in the greater Minneapolis area have closed restaurants and left communities on edge.
ICE agents detain workers at Mexican restaurant after visiting business for lunch
Arrests by ICE agents in the greater Minneapolis area have closed restaurants and left communities on edge.
ICE agents detain workers at Mexican restaurant after visiting business for lunch
Arrests by ICE agents in the greater Minneapolis area have closed restaurants and left communities on edge.
ICE agents detain workers at Mexican restaurant after visiting business for lunch
Arrests by ICE agents in the greater Minneapolis area have closed restaurants and left communities on edge.
ICE agents detain workers at Mexican restaurant after visiting business for lunch
Arrests by ICE agents in the greater Minneapolis area have closed restaurants and left communities on edge.
ICE agents detain workers at Mexican restaurant after visiting business for lunch
Arrests by ICE agents in the greater Minneapolis area have closed restaurants and left communities on edge.
ICE agents detain workers at Mexican restaurant after visiting business for lunch
Arrests by ICE agents in the greater Minneapolis area have closed restaurants and left communities on edge.
ICE agents detain workers at Mexican restaurant after visiting business for lunch
Arrests by ICE agents in the greater Minneapolis area have closed restaurants and left communities on edge.
What happened to Minneapolis businesses when ICE came to town
Federal immigration agents have been circling El Burrito Mercado, a prominent Mexican supermarket and restaurant in St. Paul, Minnesota, for the last week.
GOP Cuts Will Cripple Medicaid Enrollment, Warns CEO of Largest Public Health Plan
Martha Santana-Chin, a daughter of Mexican immigrants, last year took the helm of L.A. Care, the nation’s largest publicly operated health plan. She warns that looming federal cuts will push up to 650,000 people off L.A. Care’s Medicaid rolls by the end of 2028.
Jeez, leave the governor's entertainment budget alone
I’m a Republican. I love it when the liberal media lash out at a Democrat (it happens so seldom). Such is the case of Daniel J. Chacón’s headline story (“Gov.’s
How Trump's tariffs ricochet through a Southern California business park
America's trade wars forced Robert Luna to hike prices on the rustic wooden Mexican furniture he sells from a crowded warehouse here, while down the street, Eddie Cole scrambled to design new products to make up for lost sales on his Chinese-made motorcycle accessories.
How Trump's tariffs ricochet through a Southern California business park
By Timothy Aeppel VALENCIA, California, Jan 9 (Reuters) - America's trade wars forced Robert Luna to hike prices on the rustic wooden Mexican furniture he sells from a crowded warehouse here, while