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That bag of frozen berries may be healthier than you think
Whether it’s fresh or frozen, fruit always offers a range of important nutrients – though the specifics depend on which fruit you're choosing.
Toledo Tinkers mobile science program receives national recognition
Imagination Station’s Toledo Tinkers program, which brings hands-on science education to underserved communities, has received a national award for its ...
New iMac and 14-Inch MacBook Pro With M6 Chip Expected Tomorrow
After announcing a new iPad mini today, Apple is expected to introduce updated iMac and 14-inch MacBook Pro models with the M6 chip, which debuted in the new Mac mini in August. No design changes have been rumored for these Macs. No design changes have been rumored for these Macs.
Which MLB Team Should Sign NPB Star Teruaki Sato?
Japanese left-handed outfielder Teruaki Sato will be playing in Major League Baseball in 2027. In case you aren’t familiar with Sato, he just accomplished the Triple Crown in the NPB and has hit 79 home runs and stole 18/23 bases during the last two seasons. This past season, he had a .991 OPS, and during …
Johnson Controls to Sell Intrusion Business, Including DSC and Qolsys
The business will operate as an independent company under Truelink Capital, which plans to invest in product development and expand into new markets.
California ballots targeted by Trump can be counted for now under court ruling
The ruling is a blow to the Trump administration, which claimed the ballots might have gone to noncitizens and wanted to set them aside.
Social Media Campaign Shows Actors Struggling to Qualify For Insurance
Cheyenne Jackson launched the social media effort, which has had a massive influx of requests as actors face a tough jobs environment in Hollywood.
Healthcare providers already see patient stress over looming Medicaid work requirements
Providers say work requirements, which go into effect for some Medicaid recipients, do not align with reality for many patients.
Cook County Public Health Reminds Families to Get Their Children Tested for Lead - Cook County Department of Public Health
In recognition of National Lead Poisoning Prevention Week, Oct. 25-31, Cook County Department of Public Health is bringing increased attention to Illinois’ new universal childhood blood lead testing law and lead dangers. The new state lead testing requirements, which took effect July 1, 2026, require all children to receive blood lead tests at ages 12 months and 24 months, regardless of where they live. Also, children 6 years old and younger must receive a lead exposure risk assessment through a questionnaire administered by a healthcare provider.
New test could flag which men need aggressive prostate cancer treatment and which don't
The Decipher genomic test could help doctors decide which high-risk prostate cancer patients need abiraterone hormone therapy and which can skip it.
Blue Frog founder John Campbell named group CEO of Avidly
Avidly, a global technology services company specializing in customer relationship management and go-to-market solutions, appointed Blue Frog Founder John Campbell as group CEO, effective Oct. 7. Campbell leads the company, which has nearly 300 employees across nine countries, from its North American offices in Waukee. He will continue serving as CEO of Blue Frog. Campbell…
Lionsgate, Steven Paul's SP Media Form New Business, Film Joint Venture
Lionsgate and Steven Paul's SP Media are launching a new joint venture which will have the latter making a capital investment that will allow the former to continue its diversification of 3 Arts and other businesses.
Apple releases iOS and macOS 27.2 with new Siri AI features, new Music logo
Included is the ability to limit which applications Siri can directly access.
Grading Seahawks QB Sam Darnold's performance in win over Chiefs
Sam Darnold had a high-volume performance in the Seahawks’ win over the Chiefs, but his problem with turnovers persisted, which impacted his grade.
7 Numbers That Explain Anthropic’s Business
We broke down the A.I. company’s key figures, which give insight into the health of its business, its future plans and who’s in charge.
Former Sarasota Big Lots to get new life as antique mall
Nearly 50 antique and collectible vendors have signed up to sell their wares in the former Big Lots, which is being transformed into an antique mall.
Wilmington Health facility sells for $9.4M
Wilmington Health’s main facility recently sold for more than $9 million. The 66,000-square-foot facility located at 1202 Medical Center Drive was purchased by Charlotte-based real estate investment firm Cedar Square in a $9.4 million sale-leaseback transaction, according to a deed recorded Oct. 21. Wilmington Health will continue leasing the facility, CEO Jeff James told the Business Journal in September. James said the lease term would likely be five years, with most services eventually transferring to a new medical office building under construction in the Midtown Park office area near The Pointe at Barclay. The Wilmington Health facility was originally listed earlier this year at $11.85 million. A Wilmington Health representative did not respond to a request for comment by press time. Steve Hall, vice president of BlueCoast Commercial, represented Wilmington Health in the transaction. “Wilmington Health wanted to unlock the value in its real estate without disrupting a single patient visit, and a sale-leaseback let them do exactly that,” said Hall in a text to the Business Journal Monday. “Cedar Square gets a long-term, absolute net investment anchored by one of the region’s leading physician groups, and Wilmington Health keeps its home on Medical Center Drive while redeploying that capital into care.” The sale marks Cedar Square’s first entry into the Wilmington market, according to Jon Dixon, the firm's managing partner and founder. “We are attracted to Wilmington's growth and what we see as strong long-term fundamentals,” said Dixon in an email Monday. “Population growth, relative affordability, and quality of life make it a compelling market for us. The climate and proximity to the coast are a big part of that appeal.” He added, “We hope to pursue additional opportunities across retail, industrial, medical office and multifamily in Wilmington. We will evaluate opportunities individually and remain disciplined about the properties we pursue. We would like this acquisition to be the beginning of a broader investment presence in Wilmington.” Given the facility’s age, Dixon said the site could eventually be redeveloped, potentially for medical office space or housing. Dixon said recent announcements from UNC Health and Atrium were among the factors behind the firm’s growing interest in Wilmington’s medical-office market. The announcements involve competing proposals for hospital expansion in New Hanover County, which are subject to the state’s Certificate of Need process. “Medical office remains one of the most sought-after asset classes in commercial real estate,” said Hall, “and well-located (medical office buildings) with strong operators are scarce in Southeastern North Carolina.” According to Dixon, Cedar Square describes itself as a boutique, hands-on real estate investment firm that values direct relationships with tenants and the communities where it owns property. “We’re very hands-on, and we like to be in direct contact with all of our tenants and the communities in which we own,” Dixon said. He added, “We’re definitely interested in building a presence with local owners, brokers and businesses or tenants.”
A neglected particle from the dawn of time could explain why everything in the universe exists
A hypothetical particle could have briefly held more energy than everything else in the infant universe combined, which could help explain how matter won out over antimatter.
Jackson Hinds Comprehensive Health Center provides prenatal care
Dr. Tonya Hawkins, a new provider with Jackson Hinds Comprehensive Health Center, visited Today at 11 with information about what Jackson Hinds provides, which is comprehensive care, including prenatal and gynecologic services for women, with multiple locations in the metro area.
Assassin’s Creed Black Flag Resynced ‘New Game+’ update launches October 27
The final major content update for Assassin’s Creed Black Flag Resynced, which adds New Game+ and other features, will launch on October 27 at 7:00 a.m. PT / 10:00 a.m. ET, publisher Ubisoft …
Will Proposal 2 get money out of politics? One researcher says ‘not really’
Michigan’s Proposal 2, which seeks to limit political spending by regulated utilities and government contractors, faces potential legal challenges due to existing Supreme Court rulings protec…
LSU Tigers Star Transfers Exceeding Expectations Through Bye Week
The LSU Tigers reconstructed pretty much their entire offensive roster, and then added some finishing touches to the defense. They have a lot of newcomers on both sides of the ball, which has created some competition for snaps.
Zelda 40th Anniversary Switch 2 Pro Controller restock tracker: we’re watching these retailers
🎮 Nintendo will release a Zelda 40th anniversary Switch 2 Pro Controller on October 29 💰 It costs $99.99, the same as other limited editions 📅 A restock could occur on launch day at Walmart and Best Buy 🚨 Our Zelda Switch 2 Pro Controller restock tracker @mattswider on X will send out an alert when stock appears Walmart: Zelda Pro Controller Best Buy: Zelda Pro Controller Amazon: Zelda Pro Controller Target: Zelda Pro Controller GameStop: Zelda Pro Controller Nintendo is releasing a special limited edition Nintendo Switch 2 Pro Controller to celebrate the 40th anniversary of The Legend of Zelda series. It releases on October 29, 2026, which is when we expect to see a long-awaited restock of the hard-to-find controller. 🚨 We’re tracking Zelda Switch 2 Pro Controller stock updates. If you’d like to know when more stock arrives, follow Matt Swider on X and turn on notifications. You can also become a free or paid subscriber to The Shortcut to help support our work. 🚨 The Switch 2 Pro Controller features the same striking gold and royal emerald color scheme of the Nintendo Switch 2 The Legend of Zelda 40th anniversary edition, and also includes a fun little easter egg on the back: an 8-Bit Link. 🚨 Want the Zelda 40th Anniversary Switch 2 Pro Controller? Drop your email for restock alerts before it sells out. ⤵️ Subscribe This is the same Nintendo Switch 2 Pro Controller we’re used to, aside from the intricate design, but it means you’ll have to pay more as a result. It costs $99.99 instead of the standard $89.99. However, the Pro Controller is the easiest way to play the best Switch 2 games in TV mode. If you’ve been searching for a Zelda 40th Anniversary Switch 2 Pro Controller restock, here’s everything you need to know. Zelda 40th anniversary Switch 2 Pro Controller should restock at these retailers We’ve seen retailers such as Walmart and Best Buy restock items on release day, even when pre-orders have sold out. It’s likely that the Zelda Switch 2 Pro Controller will be up for grabs on October 29, 2026, when the controller and console launches. Demand will be high, and stock could sell out fast. However, we’ll be keeping a close eye on every major retailer, including Target, Amazon, GameStop, and the Nintendo Store and will alert our followers as soon as stock goes live. Why you can trust our Zelda Switch 2 Pro Controller restock tracker We’ve already helped over 400,000 people buy a PS5 when it was in and out of stock during Covid, and we’ve helped our subscribers continue to secure hard-to-find items. The Shortcut followers were some of the first to secure the Switch 2 when it went on sale, and we’ve also helped countless others snag limited edition consoles like the PS5 30th anniversary edition. The Shortcut and Matt Swider on X offer exclusive Zelda 40th anniversary Switch 2 Pro Controller restock updates with up-to-the-second US store inventory checks at the biggest retailers. You’ll receive an instant notification on X (if set to on) as soon as new stock arrives. Up next: Call of Duty: Modern Warfare 4 review roundup: ‘a strong return to form’ Subscribe Adam Vjestica is The Shortcut’s Senior Editor. Formerly TechRadar’s Gaming Hardware Editor, Adam has also worked at Nintendo of Europe as a Content Marketing Editor, where he helped launch the Nintendo Switch. He also runs a retro gaming YouTube channel called Game on, boy! Follow him on X @ItsMrProducts.
Salesforce vs. International Business Machines: Which Technology Stock Is a Better Buy in 2026?
Salesforce trades at a lower forward multiple, while IBM offers cheaper valuation on sales, but their balance sheets tell starkly different stories.
I'm a massive horror fan, and here are the 13 scariest, spookiest video games for PC and consoles I think you should play this Halloween
The nights are drawing in, which can only mean one thing: more bed. But also the impending frights and sights of All Ha…
📈 Monday data: The bottleneck isn’t intelligence
In the AI Investment Brief today: CapEx updates and lease commitment breakdowns Anthropic co-founder Jack Clark recently said in a speech at the IMF that the singularity has begun: For many years, researchers and science fiction authors have forecast a future in which AI systems drastically increase the pace of overall scientific and technical progress, making things move so quickly that it is hard for humans to keep up. They call this the singularity. I believe that this year we have gained convincing evidence that it has now begun. This follows Anthropic’s claim that in August, 26% of its AI R&D was led by Claude, with a human supervising its work. In October, OpenAI posted 719 math manuscripts1 made by its internal model. Math and coding are two fields where a research loop can close without leaving the desk. But can the loop close in the rest of science? Subscribe The loop is real The idea is not new. Mathematician Irving John Good, who had worked with Alan Turing at Bletchley Park, argued that a machine smarter than us “could design even better machines; there would then unquestionably be an ‘intelligence explosion,’ and the intelligence of man would be left far behind.” The Gödel machine, a self-improving computer that can rewrite its own code better than its prior, was first proposed in 2003. In 2025, researchers at Sakana AI and the University of British Columbia set out to show that this was possible. Their agents iteratively improved their own code through a feedback loop, resulting in gains of 30 pp on SWE-bench and more than 15 pp on Polyglot, testing coding skills beyond Python. The idea has since been tested in other labs. A Gemini-powered agent called AlphaEvolve found a faster matrix multiplication kernel used for training Gemini, speeding up the kernel by 23% and cutting Gemini’s training time by 1%. In China, MiniMax reported that its M2.7 model worked on improving its own agent’s harness, skills, sampling and memory. Over 100 rounds of rewriting led to a 30% gain, per its internal evaluations. In each case, what was being rewritten was not the model itself but everything around it. Is it better than human work? In September this year, in what seemed like a milestone, an AI-built agent proved as good at improving other AI agents as a human-built one. It did that in what appeared to be half the steps. But the result was inconclusive: the differences between runs were greater than the difference between the AI- and human-built agent results. Nonetheless, this is increasing the chatter around recursive self-improvement (RSI) in AI. Google’s Sundar Pichai said that “you have RSI loops along with AI researchers in various aspects of model development.” Sakana AI published a paper on RSI through multi-agent collaboration, finding that after two cycles its system scored 1.2–1.6x better per output token than the base model across four research benchmarks. Ramez Naam challenges that view. He splits AI self-improvement into five overlapping types. The first four describe how autonomous the AI is; so far, only types 1 and 2 have been observed. The fifth type describes accelerating returns, and he notes that greater autonomy doesn’t guarantee a takeoff scenario. Instead, each round of self-improvement would need to deliver at least as much as the last. The results from Sakana, AlphaEvolve and MiniMax above might look like type 3 or type 4 autonomy. But in each case, the AI wasn’t updating its own weights directly, only the ancillary parts — the harness, the memory. And where Claude leads its own R&D, for now a human still supervises.
Oct. 21: Douglas County Board of Health reviews lead prevention, WIC funding and upcoming health priorities
The Douglas County Board of Health approved its consent agenda, which included agreements with hospitals, nonprofits and government agencies, and
Rhode Island FC hires Lou DePaoli as president of business operations
DePaoli said he intends to prioritize making Centreville Bank Stadium, which currently operates about 50 dates annually, a year-round entertainment destination.
Scientists Estimate That Europe's Scorching Summer Heat Killed More Than 50,000 People in Urban Areas
The new research, which has not yet been peer-reviewed but was accepted for publication, suggests that climate change is responsible for two-thirds of the deaths
Lindsay Lohan revisits key ‘Mean Girls’ filming location on set of new movie
Lindsay Lohan held a ‘Mean Girls’ reunion with director Mark Waters on the set of their new movie ‘Return to You,’ which is filming at the original Heron house used in the 2004 teen comedy.
D. C. Circuit Review: Reviewed – Some unfinished business
The D. C. Circuit published two opinions last week in cases that were argued last term. Mennonite Church USA v. DHS, No. 25-5209, which was heard in February of this year, involved a challenge to the Trump Administration’s policy of pursuing immigration-enforcement operations at houses of worship. Prior to 2025, the federal government largely maintained […]
In brief: Orlando Bloom, Elijah Wood joining 'The Gentlemen'
Netflix is rounding up more gentlemen. Tudum announced Orlando Bloom, Elijah Wood and Ed Speelers are joining stars Theo James and Kaya Scodelario for the third season of The Gentlemen, which is currently filming in the U.K. and Morocco. Also added to the series cast are Dexter Fletcher, Robert Carlyle and Bugzy Malone, who appeared in the 2019 film that inspired the Netflix series. Daniel Ings, who played the drug-addled older brother Lord Frederick “Freddy” Horniman to James’ criminal mastermind Eddie Horiman, told HATC magazine he will not return for the third season. Netflix has not confirmed this …The action-adventure series Fallout has inspired a new reality show. Prime Video has revealed Fallout Shelter: The Experiment, an unscripted competition inspired by the post-apocalyptic drama series and the video game universe. The show “invites everyday participants to test their aptitude for the apocalypse in Vault-Tec's state-of-the-art bomb-proof vault shelters," according to Prime Video. Contestants will “go head to head in a series of high-octane drills, psychological dilemmas and morally challenging behavior trials.” The winner walks away with a $1 million prize. Fallout Shelter: The Experiment will begin streaming in January 2027 … TNCMS.AdManager.render({region: 'fixed-big-ad-top-asset', slot: 1, fold: "above"}); Bravo renewed a slate of its reality shows ahead of Bravo’s Fan Fest on Saturday. New York-based In the City has been greenlit for season 2, while Next Gen NYC is coming back for a third season. For viewers seeking a little Southern charm, The Next Gen universe will be expanding with a spinoff based in Atlanta, and Southern Hospitality is moving forward with a fifth season. Premiere dates have not yet been announced … Copyright © 2026, ABC Audio. All rights reserved. Thank you for reading kmaland.comAt KMA, we attempt to be accurate in our reporting. If you see a typo or mistake in a story, please contact us by emailing kmaradio@kmaland.com.
Partner1 Renews WBENC Women's Business Enterprise and Women-Owned Small Business Certifications
Recertification caps a year in which founder and CEO Juhi Saha was named to Inc.’s 2026 Female Founders 500 and Partner1 was named an Inc. Power Partner for the second year runningPLEASANTVILLE, N.Y., Oct. 26, 2026 (GLOBE NEWSWIRE) -- Partner1, the advisory firm and software platform behind the partnership strategies of fast-growing B2B software companies, today announced it has renewed its Women’s Business Enterprise (WBE) and Women-Owned Small Business (WOSB) certifications from the Women’s Bu
Scientists have learnt how to transmit smells over the internet
Scientists have developed Scentronic, which transmits information about smells via the internet. At present, the system can recognise five scents and reproduce them remotely.
Two encouraging stats after Inter’s latest comeback victory
Inter had to come from behind yet again to claim a 2-1 victory over Fiorentina in Serie A on Sunday afternoon, which has kept the Nerazzurri at the top of the league table for another week and has pro...
2 Kentucky Wildcats make CBS Sports’ preseason top 101 College Basketball players list
Which Kentucky Wildcats received some love from CBS Sports ahead of the 2026-27 season?
LSU’s Project Wellness Club provides students with resources for mental, physical health
The LSU Project Wellness Club hosted pumpkin painting and spooky movie night on Thursday, which was just one of the many events the club puts on for students to de-stress and have an on campus outlet. The club focuses on students’ mental health. Co-president and psychology senior Lindsey Puente describes the club as collaborative, saying...
Live Nation Entertainment (LYV) Stock Trades Near Fair Value Following Its 121% Run
Live Nation Entertainment has rewarded long term holders, and the stock now trades around US$173.44, which puts its cash generation in sharp focus. With that kind of share price level, the question is whether the current market value can be backed up by the cash flows the business is expected to produce. Over the past 3 years the stock has returned 120.7%, so a lot of future cash flow strength is already being reflected in the price. The company leans heavily on converting concert promotion...
Groundbreaking Guidelines Released for Women’s Heart Health
The guidelines, which were authored by four major medical groups, are a framework for how hormonal changes up heart disease risk from puberty to after menopause.
Apple Music unveils logo that was physically “made by sound”
Apple has revealed the first rebrand for its Apple Music service, which was made in collaboration with musician Fred Again by passing sound waves through a pool of oil.
Hollywood's uncanny evolution of evil billionaire tech bros
If you really want to understand the extent to which everyone thinks Silicon Valley is so uncanny these days, watch "Cupertino."
Bologna ponder sending Dovbyk back to Roma in January
Artem Dovbyk has his reasons. And they’re all legitimate, given his slow recovery after that January injury, which would be scary for anyone who doesn’t want to suffer a relapse, and therefore re-...
Conserving a connected ocean
For Seychelles and other countries across the Western Indian Ocean region, marine conservation is a fundamental component of national development. But the ocean observes no national borders, which makes international cooperation and common financing instr
Mike Brown Drops Blunt Quote After Knicks Lose to Magic
New York Knicks head coach Mike Brown dropped a blunt quote after the Knicks lost to the Orlando Magic 111-102 on Sunday night.The start to the new NBA season has not gone well for New York, which is 0-3 to begin the season. Considering this team just won the NBA Championship back in June, it’s […] The post Mike Brown Drops Blunt Quote After Knicks Lose to Magic appeared first on HEAVY.
iPhone Duo vs. Samsung Galaxy Z Fold 8: Which foldable is the best?
Can't decide between iPhone Duo and the Samsung Galaxy Z Fold 8? Here's our verdict
Updated cast makes ‘The Social Reckoning’ shine
On Oct. 9, “The Social Reckoning” came out in theaters, which is a follow-up to the 2010 film “The Social Network.” Both films catalog events in the life of Facebook,
Holland Taylor says ‘Two and a Half Men’ ‘never paid me very well,’ even after 4 Emmy noms
Holland Taylor is looking back on her 12-season run on ‘Two and a Half Men,’ during which time, she claims she never got a raise: ‘I loved a lot about that show, but they were not full of courtesies.’
Attackers kill nurse, severely injure health worker responding to Ebola case in eastern Congo
The World Health Organization reports that a nurse has been killed and a health worker severely injured in an attack while responding to an Ebola alert in Congo. This attack, which occurred on...
Young Scientists Congress: New technologies take centerstage at science exhibition in Wenzhou
The World Young Scientists Congress has opened in Wenzhou, east China's Zhejiang Province. More than 800 scientists and entrepreneurs from over 60 countries and regions are attending the event which includes an exhibition of the latest technologies. We spoke with some of the visitors to the event.
Bengals Shut out in Disastrous First Half vs Ravens
The Cincinnati Bengals are off to a first half they’d like to forget. Cincy trails the Baltimore Ravens 13-0 in Baltimore.The story has been the Cincinnati Bengals’ defense which has been struggling against this Ravens offense.The Ravens got off to a hot start as Zay Flowers took a 48-yard pass to the house from backup […] The post Bengals Shut out in Disastrous First Half vs Ravens appeared first on HEAVY.
Alaska Democratic Senate candidate Mary Peltola and her family suffer minor injuries in car crash
Peltola required medical attention after the accident, which happened when another vehicle crashed into the one transporting Peltola and her family, the campaign said.
Sharpen memory and fight brain fog with simple 60-second trick from a neurologist
Dr. Rhonda Voskuhl explains why crosswords and sudoku miss the mark for brain fog and which timed word games actually target verbal memory loss.
Supercurrent enables the reading of quantum information without destroying it
One of the fundamental challenges of quantum computing is obtaining information from a quantum bit, or qubit. Unlike a conventional bit, which can be read repeatedly without altering its content, direct ...
Defender turns striker and scores in Bayern win
Bayern Munich beat Freiburg 3-1 away from home to reclaim top spot in the Bundesliga on Sunday (25).Dayot Upamecano was one of the standout performers, scoring the opener with a move in which he playe...
Google's privacy policy now has a loophole for using your Gmail and Photos data in ads
The change sits in Google's updated privacy policy, which took effect on October 16 and was first spotted by Android Authority. The policy has long said, "We...
'You Can See Everything' Surges With $19.5M at Box Office; 'Clayface' Takes No. 1
NEW YORK (AP) — DC Studios scored a modest, R-rated win with “Clayface,” landing a $24 million opening weekend, according to studio estimates Sunday. But the biggest success story in theaters remained A24’s Elizabeth Holmes documentary “You Can See Everything,” which pulled in $19.5 million in its ...
Oregon fires offensive coordinator Drew Mehringer after team scored just 10 points in loss to Illinois
Saturday's loss marked the third straight game in which Oregon scored under 20 points.
Epic CEO Tim Sweeney lambasts “abhorrent” Steam AI Disclosure Policy claiming labels double as “political statement”
Epic Games CEO Tim Sweeney called Steam’s AI disclosure policy abhorrent, arguing that it exposes developers to backlash from anti-AI detractors. Valve has implemented and updated the policy since 2024, which states that AI-generated content, including artwork, text, music, and assets, excluding assistant tools, requires formal disclosure.
RJW Logistics to open second Northwest Arkansas office
Chicago-based RJW Logistics Group, which has a Bentonville office, plans to open an additional Northwest Arkansas office amid client growth and to support demand for a new logistics program offered...
ESMO: Roche touts ‘convincing’ phase 3 KRAS data after win over rivals
Roche has shed more light on its investigational KRAS G12C inhibitor's phase 3 victory over Amgen’s Lumakras and Bristol Myers Squibb’s Krazati. The open-label Krascendo 1 trial enrolled 338 people with previously treated KRAS G12C-mutated non-small cell lung cancer (NSCLC). Patients who had already received a KRAS G12C inhibitor or pan-KRAS/RAS inhibitor were excluded from the trial. Participants received either divarasib once daily, Lumakras once daily or Krazati twice daily. Roche announced back in July that divarasib had demonstrated statistically significant improvements in progression-free survival (PFS) and overall survival (OS), meeting the trial’s primary and key secondary endpoints. But the Swiss pharma had been holding back the detailed data until now. At the European Society for Medical Oncology (ESMO) Congress in Madrid, Roche revealed that median OS for the 167 patients who received divarasib was 17.7 months, compared to 12 months for the 171 patients who received Lumakras or Krazati. The benefit was similarly clear when it came to median PFS, which stood at 9.8 months versus 5.7 months, respectively. A total of 44% of patients receiving divarasib were alive without disease progression at one year, compared to 24% of the control group, according to Roche’s presentation. It was a similar story for the objective response rate, which came in at 58% for divarasib versus 32% for the control group, while median duration of response was 11.9 months versus 6.9 months. Stefan Frings, M.D., Ph.D., deputy chief medical officer at Roche Pharma, told Fierce that the data made for a “very comprehensive, strong package, which should be convincing to health authorities.” “It’s an important advance for patients with lung cancer,” Frings said in an interview at a Madrid hotel during the conference. “It's a second-line setting, and patients who receive divarasib benefit compared to the current first-generation KRAS G12C inhibitors by having far longer overall survival,” he continued. “They live longer. They have better progression-free survival, better response rates, and with a safety profile which is—if [anything]—even better,” he said. According to Roche, 4.8% of patients receiving divarasib discontinued treatment due to treatment-related adverse events, compared to 11.7% in the control group. Serious treatment-related adverse events were also less common with divarasib, at 7.8% versus 15.2%. Roche’s confidence in divarasib had been building even before this phase 3 success. The candidate had already shown better potency and selectivity than the incumbent KRAS G12C inhibitors Krazati and Lumakras in preclinical tests. After cross-trial comparisons suggested that the edge translated into better clinical outcomes, Roche axed a study comparing divarasib to the chemotherapy docetaxel and went toe-to-toe with Lumakras and Krazati. “We designed the drug on purpose with higher potency and better selectivity,” Frings explained. “So, based on preclinical models, we clearly knew it would be superior to the first generation.” “It’s honestly not so frequent that pharma companies go head-to-head,” he added. “But if you want to make a point, if you want to convince payers, prescribers and patients … then a head-to-head win is rather rewarding.” While Amgen and BMS reached the regulatory finish line first for KRAS G12C-mutated, locally advanced or metastatic NSCLC in 2021 and 2022, respectively, they have struggled to capitalize on their head start. Krazati brought in $55 million for BMS in the second quarter, while Lumakras delivered $111 million to Amgen. For its part, Roche is aiming for peak divarasib sales of 1 billion to 2 billion Swiss francs ($1.2 billion to $2.5 billion), according to Frings. The Big Pharma is currently recruiting patients into a phase 3 trial comparing divarasib plus Keytruda against Keytruda plus chemotherapy in previously untreated advanced or metastatic nonsquamous KRAS G12C-mutated NSCLC. Roche has previously suggested that sales in metastatic disease would account for most of the forecast. Frings was tight-lipped on the exact timeline for a regulatory filing but said the Swiss pharma is “certainly keen to get this to as many patients as possible around the world.” Roche has more RAS drugs coming up behind divarasib. The pharma has already launched phase 1 trials of a pan-RAS inhibitor called RG6505 and a KRAS G12D inhibitor dubbed RG6620 in solid tumors. Roche’s partner Chugai Pharmaceutical is also testing a pan-KRAS inhibitor called AUBE00. Roche has made a “deliberate effort” to test a range of RAS drugs, Frings said. “If you have many rare mutations and you are scrambling to find sufficient patients, a pan-RAS inhibitor makes a lot of sense,” he explained.
Obama, in Midwest, assails 'cruelty' and indecency from Trump and his allies in the midterm campaign
Obama remains the Democratic Party’s best motivator nearly a decade after leaving the White House. And he's taking his star power on the road in the final days of the midterm elections, which will help determine the balance of power in American politics on Nov. 3.
Ranked: Countries With the Most Trust in Science
Discover which countries trust science the most and least in 2025, and how education, religion, and culture shape public confidence.
Week 7 Early Games Open Thread
The only games I’m really keyed in on are the Steelers and Texans both losing to the NFC team and then decided which team between the Bengals and Ravens are the bigger threat to Denver’s future playoff seeding arrangement. Here are the games we have to watch today before the Denver Broncos take on the […]
‘Wicker’ star Alexander Skarsgård says he’s ‘not very good with being earnest’
‘Wicker’ star Alexander Skarsgård says he’s ‘not very good with being earnest,’ which his latest role, as a sexy basket, required.
The educational divide could spell trouble for Republicans
Republicans tend to run better among voters without a college degree than those with one, which has battered Democrats in recent presidential elections. But that same pattern could give Democrats a potentially decisive boost in next month’s midterms.
Pols & Politics: Questions raised in recent polling on Gov’s race as RNC survey shows tight matchup
Recent polls on the upcoming race for Massachusetts Governor, which showed double-digit leads for Gov. Maura Healey over GOP challenger Mike Minogue, have raised questions on their methodology.
Juventus is limiting one of their best players
Kerim Alajbegovic was expected to receive considerably more playing time following Kenan Yildiz’s injury, which is set to keep the attacker out of action until the end of 2026. However, things have ...
Unwanted endorsement: Political ad causes uproar at Jerusalem's Lev Academic Center
Those who know the highly regarded college, which since 1969 has produced religious graduates with degrees in a variety of engineering fields and nursing, were likely surprised. Thousands of drivers a...
Which AMD CPU Is Equivalent To The One In The PlayStation 5 Pro?
Exploding console prices have led gamers to look for an AMD CPU that's equivalent to the one in the PlayStation 5 Pro. The closest match is the Ryzen 5 5600x.
Black Power Marketplace highlights Black-owned businesses in Rochester
Rochester, N.Y. — The Community Justice Initiative held the Black Power Marketplace, which featured local vendors that offered food, clothes, art, wellness serv
Alabama Renaissance Faire celebrates its 40th year
FLORENCE — Alabama’s Renaissance Faire is celebrating its 40th year this weekend at “The Fountain on the Green,” which is also known as Wilson Park. The event features costumed performers
New evidence suggests spinosaurus spent most of its life underwater
Millions of years after animals first conquered land, some took an extraordinary evolutionary U-turn and returned to the water. Using machine learning and thousands of fossil measurements, Yale scientists have uncovered surprising clues about which prehistoric creatures truly became aquatic. Their findings suggest that Spinosaurus spent most of its life underwater, while some ancient marine reptiles previously thought to be fully aquatic actually spent considerable time on land.
Netflix’s Leadership Shake Up…Explained
(Welcome to the “Most Important Story of the Week”, my bi-weekly strategy column analyzing the most important (but often not buzziest) news story of the last two weeks. I’m the Entertainment Strategy Guy, a former streaming executive who now analyzes business strategy in the entertainment industry. Please subscribe.) Well, I had a simple article planned for this week. Called “Whoa, I Missed It!”, I’d take a gander at a few important-but-under-the-radar stories I didn’t cover while I wrote about all things “Skydance. (Formerly known as “the saga of Netflix trying to buy Warner Bros., but not Discovery, then Paramount-Skydance bought all of Warner Bros. Discovery”.) Alas, that article will have to wait. Netflix made news. Ironically, my “Whoa, I Missed It!” article would have mostly been about “content” strategy decisions, which is also what today’s article is about. But instead of the entire industry, this article will only cover Netflix’s decision to upend their film and TV content teams. Just that! So that’s the full topic of the day. I’m going to tackle the issue in the opposite direction of the way “stuff” flows: uphill. We’ll start at film, then move onto TV, and then onto the CEOs themselves, and the strategy questions that still remain. But we start with the numbers driving this. Let’s dive in. Subscribe Most Important Story of the Week - Netflix Upends Their Corporate Hierarchy I’ve got a lot of thoughts, but we’ll start with the most common response to yesterday’s article. Let’s Talk Stock Price More than one person, responding to what I published two days ago, pointed out that, well, actually, the thing driving Netflix’s actions is this: In short, stock price! Even if Netflix isn’t obsessed with their own share price—they probably are, but, for the record, my strategic advice to every CEO is to absolutely ignore stock prices, which will, ironically, probably help the stock price long-term—most everyone thinks they are. By the way, I prefer market capitalization to stock prices, because it’s a more apples-to-apples way to compare companies: But there’s an even better way to look at it, and it kinda casts some doubt on the entire push here: price-to-earnings. I have a long list of articles that I wish I had written, and chief among them is an article titled, “Am I Still a Netflix ‘Bear’?” meaning someone who thinks Netflix’s stock is overvalued. As of last summer, Netflix had solved their biggest problem—which for me (circa 2019) was the lack of free cash flow—but their stock was CRAZY overvalued. That’s this chart here: Why did Netflix’s stock price increase to a price-to-earnings ratio of 50 last summer? What financial metric changed so quickly? Nothing. Given that, historically, mature entertainment companies average 10 to 20, with 16 being the average, that increase made little sense. Netflix’s stock swoon these last eight or so months wasn’t irrational; the stock price rise last year was. So if you want a really hot Netflix take, here it is: Netflix’s stock price has been going down because the financial industry recovered its senses, not because of any strategic mistake. Yes, that would imply that cleaning house may have been a mistake. That’s why the charts yesterday are so important, because they show that Netflix did have a strategic problem (a lack of hits) and that’s what they moved to address. (One could also argue the industry drastically overrated Netflix’s growth prospects, but that’s a financial industry problem, not a Netflix strategy problem per se. Some growth estimates are just crazy. *cough* AI *cough*) Now, the last time Netflix’s stock price crashed—circa 2022—it gave them an opening. I’d argue Netflix insiders knew they needed to expand post-COVID-19 crisis, adding advertising, cracking down on password sharing, and dabbling in sports. But if they had done that when their stock price was high, it would give folks a reason to second guess their strategy. (Arguably, last year, when Netflix pursued the Warner Bros. merger, it gave the industry a chance to review their business.) Instead, after the 2022 fall, they had the opening to make strategic changes. We may see Netflix pivot again following this latest slide. For example, the “binge versus weekly” conversation is alive and well again. Same for expanding into theaters even more. And adding both linear channels and streaming bundles. And maybe more either social, user-generated, vertical, or creator content. But the first shift came with who is making the content calls. A Message from Our Sponsor Last winter Pulp Fiction was on Netflix. For those same 90 days, it was also free, with ads, on Pluto TV and the Roku Channel. That is not a glitch, and it is not rare. The title has run on 20 different US streaming services since 2019, across 80 separate windows, and for more than 600 of those days it sat on a paid subscription service and a free ad-supported one at the same time. Almost nobody can see this, because when a title leaves a service, the record that it was ever there tends to leave with it. Reelgood keeps that record, dated to the day rather than the month: 4MM+ movie, show and episode titles across 300+ services globally, with timestamped arrivals, departures and moves across SVOD, AVOD, TVOD and vMVPD. Licensing teams price against every prior window. Rights teams check what a licensee actually delivered, and when. Pick a title you think you know: data.reelgood.com/title-availability Film - Dan Lin Want to know why I don’t opine on individual film or TV executives, especially new hires? Dan Lin. As I always caution, it’s really, really, really tough to predict which executives will succeed in new roles and which won’t. The successful head of co-production/finance partner, Rideback, Lin was considered for the head of DC Studios job before taking the job as the head of Netflix. By all accounts at the time, this was a smart hire. (That’s my read of the news coverage anyways.) But now that Netflix has fired Dan Lin, we got a slew of news stories about how he was doing a terrible job. In sports media, Bryan Curtis, new Substack writer/podcaster from The Ringer, calls this the “now you tell us” story, when you only hear the bad news after a star athlete leaves a sports team. In this case, now they tell us that Dan Lin was bad with talent after he got kicked out the door. So was Dan Lin a flop? It’s actually tough to say. While film moves faster than TV, even two years isn’t really enough time to evaluate a person’s output. The new head hasn’t really taken control. As Emily Horgan noted, it takes much longer than two years to produce animated films, so yeah, it’s definitely too early to judge in that domain. As for live-action films, I just published an article by Brandon Katz called “Netflix’s Summer of Bummer”, but I’d point out Netflix had a bad summer two years ago too. Arguably, their best summer came from KPop Demon Hunters last year and Happy Gilmore 2, the latter of which I saw credited to Lin. Then, the stories came out that Dan Lin clashed with talent, both Ben Affleck and Greta Gerwig, classic “now they tell us” factoids to explain his firing. This may have been true, but also should have been expected given that he was given the mandate to bring budgets back in check, especially after Rebel Moon. So if he made folks upset, well, that’s what he was hired to do! But also, he was described as “well-liked” at his hiring! In that case, I’m a bit sympathetic to Lin, since he may have been undercut by senior leadership, as often happens. Basically, a CEO hires a subordinate to be their “bad cop” and keep budgets in check, but then when talent complains, the CEO ends up undercutting them. That’s how I think you end up with a Narnia movie as expensive as any of the other flops, along with a film executive the town no longer likes. As a result, I think that Netflix is now executing a classic “hire the opposite” move by hiring Peter Rice. This phrase comes from my experience following football and basketball coaching decisions, where teams generally hire the opposite of who they just had. If you have an offense-minded head coach, hire the defensive guy. Or in college football, if you have a strong recruiter, then you pivot to an “X’s and Os” type of guy. Or in pro basketball, if you have a very analytically minded coach, you hire the player-friendly guy. I see that here. After dropping Scott Stuber—arguably a talent-friendly executive with lax budget control—Netflix hired the business guy to keep costs in check. Now Netflix is pivoting back to Peter Rice and presumably a more talent-friendly regime. (Disney, by the way, has done this twice: hiring business guys to succeed talent-friendly Bob Iger. It didn’t work out last time.) When it comes to Peter Rice…we’ll see! Maybe he works out, but maybe he doesn’t. I’d actually say the biggest problem is that Netflix still hasn’t solved its “IP Problem”, in that they don’t own much IP, so they just have a lower hit rate. The new executive won’t solve that. (Though buying Lionsgate would help.) Share “Content” - Bela Bajaria I almost published yesterday’s article after this column, but ended up flipping the order, because it told the story so well. So if you want the data for why Netflix is looking at TV to fix their problems, it’s in that article, this graph in particular: I know I just wrote that it’s often hard to judge executives, but Bajaria ran TV for six years and film for three and a half more. That’s more than enough to judge hit rates, and Netflix needs more hits. That’s the story. Since 2023, Netflix hasn’t had as many hit shows as it used to, and many of its previous power house TV shows have ended their runs (Stranger Things most of all). Also, many shows from 2020 to 2022 probably pre-dated Bajaria’s tenure. (That said, one thing may have been outside of Bajaria’s control, which I explain below.) Let’s lump some content strategy thoughts about Netflix and TV into one place: We’re just getting started with this issue, but the rest is for paid subscribers of the Entertainment Strategy Guy, so if you’d like to find out… Why I partially blame Squid Game for Netflix’s latest troubles… What is “the football trap”... Why it might not be the TV shows or films’ fault at all… What change I don’t think Netflix will make... How Bela Bajaria evolved Netflix’s TV strategy in smart ways… Whose departure likely submarined Bajaria’s final few years… One sneaky explanation for Netflix’s content struggles... And a whole lot more... ...please subscribe! We can only keep doing this great work with your support.
Honeywell Technologies CEO Says Business Is Growing Faster Than Expected
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CVS Health (CVS) Stock May Be Undervalued Despite Opioid Settlement
CVS Health has delivered solid gains over the past few years, and recent headlines have kept the company firmly in focus. With the stock around US$93, the question for you is whether that price is well supported by the earnings CVS generates today. Over the past 3 years CVS Health has returned 57.9%, which puts real weight on whether current earnings can shoulder the higher valuation investors are now paying. The US$315 million opioid settlement and related compliance upgrades may affect...
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Iain Armitage cried while shooting the “Young Sheldon” pilot
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Opinion | Attempted Coups. Aging Left-Wing Incumbents. Which Country Are We Talking About?
The Brazilian echoes of American politics have become too eerie to deny.
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Volunteers help out with the Pumpkin House display; still time to get involved
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Don’t ditch the yolk just yet.
What Amy Poehler’s New Series, ‘Dig,’ Gets Right About Archaeology
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VIVA Cruises confirms autumn and Christmas entertainment programme
VIVA Cruises has confirmed its autumn and Christmas 2026 onboard entertainment programme. Headline acts include performances from ‘Inspire Extraordinary’ - a live contemporary circus-style show - combining visual performance and acrobatics designed to work within the intimate setting of VIVA’s river ships. The show - which was successfully trialled earlier this year - will perform on 42 selected departures aboard VIVA TWO, VIVA ENJOY, VIVA MOMENTS and VIVA ONE during October and November.
Editorial: The ‘abundance agenda’ and permitting reform
Many Democrats now advocate for an “abundance agenda,” which loosely holds that the party should be in the business of providing “vital goods” such as housing and infrastructure, rather than
Phibro Animal Health (PAHC) Stock May Still Offer Value At This Price
Phibro Animal Health has seen its share price move around in recent years, and that raises a straightforward question for investors who focus on fundamentals. Is the current US$38.80 price tag adequately supported by the earnings the company is generating today? Over the past 3 years the stock has delivered a very large gain of 284.1%, which puts real pressure on the question of whether current earnings can carry that kind of re-rating. The business model is tied closely to recurring demand...
Local business owner faces cleanup after Toledo chemical release
Robert Duling, CEO of Skyline Party Rentals, which is located next to the MC Tank terminal on Progress Avenue, said he’s ready to resume operations.
Who’s Calling the World Series on FOX? Meet the Announcers
The 2026 World Series is here! And it’s being broadcast on FOX, which is the national TV rights holder for the Fall Classic annually. In the Fall Classic this season, it’s a battle between the Tampa Bay Rays and the Milwaukee Brewers. Whichever team claims victory in the seven-game series will become World Series Champions […] The post Who’s Calling the World Series on FOX? Meet the Announcers appeared first on HEAVY.
Open Thread World Series Game One
We get game one of the World Series tonight. I guess I’m sort of cheering for the Brewers but really it doesn’t matter. But in games three and four, Ernie Clement will be ‘providing player-first coverage’, which should be fun. Lineups: Today’s Lineups RAYS BREWERS Yandy Diaz – DH Jackson Chourio – LF Jonathan Aranda […]
Case that ‘fundamentally transforms’ business suits hits top NC court
The North Carolina Supreme Court will take a case stemming from a 2024 aircraft accident in Arkansas. Critics argued that a lower court’s decision “fundamentally transforms” rules about which businesses can be sued in this state.
This week in health care policy: October 16–23, 2026
Medical innovation FDA approves several innovative treatments. Last week, the FDA granted accelerated approval to GSK’s Jemperli for certain untreated cancers with a specific DNA defect. The treatment will eliminate the need for costly alternative treatments such as surgery, radiation, or chemotherapy, which are known to cause lasting health problems. The FDA also approved GSK’s […]
Thermo Fisher Scientific (TMO) Benefits on Broad-Based Recovery Across Life-Science Markets
Broyhill Asset Management, a Charlotte-based firm, issued its third-quarter 2026 investor letter. The letter can be downloaded here. The Broyhill Equity Composite decreased by 0.3% in Q3, underperforming the MSCI All Country World Index, which gained 1.7%. For the first nine months of the year, the Composite returned 1.9%, compared to 13.4% for the Index. The […]
Kings C Sabonis Wants to Be Primary Offensive Initiator
The Sacramento Kings got great return games from Zach LaVine and Domantas Sabonis, which is a great sign of things to come. As the season progresses, Sabonis should be a primary option on the offensive end.