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Texas city council candidate who protested ICE shooting faces 'riot participation' charge

A Texas city council candidate has been arrested on a misdemeanor charge for “riot participation.”.

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Sep 26 • 5:33 PM EDT • Politics • wsls.com
This week, we honor the professional staff of our Forensic Science...

This week, we honor the professional staff of our Forensic Science Division and Technical Investigation Division. Your meticulous work and attention to detail serves as an essential resource to our...

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Sep 26 • 1:08 PM EDT • Science • facebook.com
Art and framing store to close after 36 years in SLO County. ‘It’s time’

The business first started in 1990 when a couple took over a small art shop.

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Sep 26 • 1:00 PM EDT • Business • sanluisobispo.com
The Habit You Should Start for Better Liver Health, Recommended By Experts

For liver health, experts say sit less! It promotes a healthy liver by building muscle, keeping you active and regulating metabolism and blood sugar.

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Sep 26 • 9:00 AM EDT • Health • eatingwell.com
The full 'Harvest Moon' rises with Saturn this weekend — here's how to get the best views

The famous Harvest Moon will be the first full moon of autumn when it rises on Saturday, Sept. 26. Here's how to get the best view of it, and where to look for bright Saturn nearby.

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Sep 26 • 6:30 AM EDT • Science • livescience.com
'Paper Tiger' review: Adam Driver, Miles Teller, and Scarlett Johansson enter a heart-wrenching love triangle

Writer/director James Gray delivers an unusual mafia drama.

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Sep 26 • 5:00 AM EDT • Entertainment • mashable.com
The Houthis: Iran’s bargaining chip with Washington

The US views talks with the Houthis as a way to contain the scope of the conflict with Iran, while Tehran sees them as a means to translate military gains in the Red Sea into political gains

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Sep 24 • 8:00 PM EDT • Politics • en.majalla.com
Ann Arbor business wins $425k in Marquette PitchMI semifinal

At the PitchMI semifinal Thursday in the Northern Center on NMU’s Campus, five companies vied for a $425,000 prize, giving seven-minute pitches to a panel of four judges.

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Sep 24 • 6:43 PM EDT • Business • uppermichiganssource.com
Mississippi State University College of Business offers hands-on learning

Mississippi State University College of Business Dean Scott Grawe joined Studio 3 to discuss experiential learning and entrepreneurship.

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Sep 23 • 8:26 PM EDT • Business • wlbt.com
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As health insurance costs soar, some Idaho healthcare workers pay for medical care out of pocket

Joshua and Ashley Durham run a family medicine practice, and for the first time in their lives, they have no health insurance.

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Sep 23 • 6:57 PM EDT • Health • spokesman.com
Copper Shores Community Health Foundation delivers 20 AEDs to community organizations

Copper Shores Community Health Foundation is distributing 20 AEDs to 10 organizations across the Copper Country.

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Sep 23 • 5:23 PM EDT • Health • uppermichiganssource.com
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BizTrip AI Announces Connection With Claude and ChatGPT

Users will be able to manage travel without switching to separate app or website

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Sep 23 • 8:55 AM EDT • Business • businesstravelexecutive.com
West Tennessee Healthcare announces plans to bring labor and delivery back to Henry County

West Tennessee Healthcare announced plans to bring labor and delivery services back to Henry County Tuesday, with a goal of welcoming the first deliveries in spring 2027.

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Sep 23 • 8:27 AM EDT • Health • wbbjtv.com
The Peninsula is getting a new dining option, with a taste of Tuscany

Starting early next year, The Lobby — a fifth-floor spot that serves breakfast, lunch and afternoon tea — will transform each evening into Italian restaurant Comunità.

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Sep 23 • 7:00 AM EDT • Business • chicagobusiness.com
BizTrip AI Brings Business Travel Booking Directly Into Claude and ChatGPT

SAN FRANCISCO, September 23, 2026--BizTrip AI, makers of agentic AI for corporate travel management, today announced that its core trip-planning and booking experience is now available natively inside both Claude and ChatGPT. The integration uses the Model Context Protocol (MCP) — specifically MCP "apps," which support rich, interactive rendering directly in a chat conversation — allowing travelers to search, compare, and book business travel without switching to a separate app or website.

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Sep 23 • 6:00 AM EDT • Business • finance.yahoo.com
Bloomfield plaza without power for more than a week, businesses struggle

About 20 small businesses at Wintonbury Mall in Bloomfield have been without power for more than a week, according to tenants.

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Sep 23 • 5:53 AM EDT • Business • wfsb.com
McClure Health Science HS café team receives award for excellence in school nutrition

The McClure Health Science High School café team, led by Marry Ann Sobremonte, was recognized by the Georgia Department of Education (GaDOE) School Nutrition Division with a 2026 Cafeteria Award of Excellence.

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Sep 22 • 12:36 PM EDT • Science • gcpsk12.org
Your employees have caregiving responsibilities. Is your small business prepared?

Rocket Lawyer reports that small businesses must prepare for employees with caregiving responsibilities by establishing clear policies to avoid confusion and legal issues.

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Sep 22 • 10:00 AM EDT • Business • wftv.com
The Next Frontier of Attribution Science Has Arrived

New research finds that Europe’s 2025 heat wave was made measurably worse by greenhouse gas emissions since the Paris Agreement.

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Sep 22 • 9:00 AM EDT • Science • heatmap.news
Nearly 2,400-year-old school where Aristotle taught Alexander the Great discovered in Greece

A school where Aristotle taught Alexander the Great has been found in northern Greece.

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Sep 22 • 8:00 AM EDT • Science • livescience.com
Science Done Right: New Clinical Evidence Advancing Cardiovascular Nutrition

Discover the key findings from this landmark study and what they reveal about the next generation of clinical research shaping the vitamin K2 category.

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Sep 22 • 5:56 AM EDT • Science • nutraingredients.com
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Opinion: A historic bridge still has to be a bridge

The landmark Cortland Street Bridge has been closed to cars for a year. A civil engineer argues preservation shouldn’t come at the expense of function.

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Sep 21 • 3:49 PM EDT • Business • chicagobusiness.com
City of Brooklyn Park, MN

Thank you to everyone who joined us for the third session of our Civic Engagement Education Series: Health & Well-being! We’re grateful to all of our dedicated staff, guest speakers, youth from...

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Sep 21 • 3:00 PM EDT • Health • facebook.com
iPhone 20 Pro Display Sizes Leak Ahead of 2027 Launch

Apple's 20th-anniversary iPhone lineup could feature slightly larger displays than the iPhone 18 Pro models, if a new leak shared on Weibo is accurate. Prolific Chinese leaker Digital Chat Station claims that early iPhone 20 Pro display specifications include a 6.41-inch screen with a resolution of approximately 2,686 × 1,236 pixels, while the iPhone 20 Pro Max is said to have a 6.96-inch display with a resolution of around 2,912 × 1,340 pixels.

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Sep 21 • 7:29 AM EDT • Technology • macrumors.com
This Chicago prof believes we are living on borrowed time, but it was his controversial life expectancy firm that died

A court fight between Abacus and Coventry puts former UIC professor S. Jay Olshansky’s life expectancy projections and defunct firm under scrutiny.

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Sep 21 • 7:00 AM EDT • Business • chicagobusiness.com
Can 'A Different World' sequel change lives like the original series? Hillman is back in session

Netflix's new "A Different World" sequel arrives with high expectations.

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Sep 21 • 6:13 AM EDT • Entertainment • newsday.com
iFixit Shares iPhone 18 Pro Teardown With Inside Look at New Features

iFixit today published an iPhone 18 Pro and iPhone 18 Pro Max teardown in both article and video formats, providing a closer look inside the new devices. The teardown confirms the battery capacities for the eSIM-only models: iPhone 18 Pro: 4,288 mAh (+0.8% vs. 4,252 mAh for iPhone 17 Pro) iPhone 18 Pro Max: 5,567 mAh (+9.4% vs.

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Sep 20 • 11:44 PM EDT • Technology • macrumors.com
Jessica Chastain series shelved in wake of Charlie Kirk assassination finally gets 2027 release

Jessica Chastain’s ‘The Savant,’ shelved days before its planned 2025 release following Charlie Kirk’s killing, has officially been given a release set for 2027.

ew.com logo
Sep 20 • 5:51 PM EDT • Entertainment • ew.com
Boston 25 News

The Massachusetts Department of Public Health announced the eighth human case of West Nile virus in Massachusetts on Friday.

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Sep 20 • 11:19 AM EDT • Health • facebook.com
Detroit Free Press on Instagram: "Two teams from the Savannah Bananas traveling baseball tour came to Comerica Park for a pair of games on Sept. 18-19. Rivals the high-energy Party Animals and the stunt-performing Firefighters, brought their brand of baseball entertainment to Comerica Park on Friday and Saturday, turning America's pastime into a mix of sports, comedy, dancing and crowd interaction. Check the link in our bio for more. 📷 by Kimberly P. Mitchell @kpmitchellphoto, Detroit Free Press #detroit #michigan #comericapark #entertainment #bananaball @thefirefighters @thepartyanimals #baseball"

17 likes, 0 comments - detroitfreepress on September 20, 2026: "Two teams from the Savannah Bananas traveling baseball tour came to Comerica Park for a pair of games on Sept. 18-19. Rivals the high-energy Party Animals and the stunt-performing Firefighters, brought their brand of baseball entertainment to Comerica Park on Friday and Saturday, turning America's pastime into a mix of sports, comedy, dancing and crowd interaction. Check the link in our bio for more. 📷 by Kimberly P. Mitchell @kpmitchellphoto, Detroit Free Press #detroit #michigan #comericapark #entertainment #bananaball @thefirefighters @thepartyanimals #baseball".

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Sep 20 • 10:03 AM EDT • Entertainment • instagram.com
As states crack down on sweepstakes casinos, VGW makes $351,000 play into Alabama politics

An Australian sweepstakes casino has contributed $351,000 to Alabama politicians and political groups as other states move to ban or restrict the industry.

al.com logo
Sep 20 • 8:00 AM EDT • Politics • al.com
Annual rally at Boston Common draws thousands of marijuana advocates ahead of historic repeal vote

This year’s event billed itself as the “first overtly political” Freedom Rally since recreational marijuana was legalized across the state in 2016.

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Sep 19 • 6:50 PM EDT • Politics • bostonglobe.com
Hawaii offers tax relief for residents, businesses impacted by Hurricane Lowell

The relief applies to GET and TAT returns for the August through November 2026 tax periods.

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Sep 19 • 5:05 PM EDT • Business • hawaiinewsnow.com
The New York Times

Japan’s health ministry released data on Tuesday showing that there are now 107,677 people who are at least 100 years old, an increase of nearly 8,000 since last year. Women make up the vast majority...

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Sep 19 • 1:31 PM EDT • Health • facebook.com
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Tottenham and Aston Villa kick off Saturday's Premier League action

SATURDAY'S FIXTURES 2026-09-19T10:24:41ZAnd the Villans side aiming to leave London with three points. 2026-09-19T10:24:07ZTottenham's starting line-up for the early kick-off. 2026-09-19T10:21:49ZFi...

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Sep 19 • 6:21 AM EDT • Sports • sports.yahoo.com
Washington Post

Booming business and a minimum investment of just 5,250 Nigerian naira, or $3.94, has made Dangote refinery’s IPO this week Africa’s largest — and inspired an explosion of memes depicting ordinary...

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Sep 19 • 3:00 AM EDT • Business • facebook.com
Brentford and Chelsea kick off Premier League weekend's action

2026-09-18T17:46:54ZTeam news has just landed at the Gtech Community Stadium and here's how both sides are lining up2026-09-18T17:43:31ZHello and welcome to our live coverage of Friday's Premier Leagu...

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Sep 18 • 1:44 PM EDT • Sports • sports.yahoo.com
'Youth' review: HBO's coming-of-middle-age comedy is messy and moving, as only Sharon Horgan can

Sharon Horgan's latest is a frank look at a 50-year-old woman's search for love.

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Sep 18 • 11:00 AM EDT • Entertainment • mashable.com
Chris Rock looked to friend Adam Sandler to figure out move from comedy to drama

Chris Rock looked to friend Adam Sandler to figure out move from comedy to drama

ew.com logo
Sep 18 • 10:19 AM EDT • Entertainment • ew.com
Attorney General Blanche's appearances at political events blur Justice Department boundaries

Attorney General Todd Blanche is blurring traditional boundaries between politics and federal law enforcement with speeches at political events that depart from longstanding norms meant to protect the Justice Department from the appearance of partisan bias.

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Sep 18 • 7:27 AM EDT • Politics • newsday.com
New Order Entertainment Warns Fans of Impersonation Scams Targeting HYNN

New Order Entertainment Warns Fans of Impersonation Scams Targeting HYNN Agency urges fans to avoid suspicious messages, block accounts, report scams to protect HYNNs rights

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Sep 18 • 3:13 AM EDT • Entertainment • chosun.com
Boston 25 News

The fan-favorite fair in West Springfield is returning this weekend for 17 days of food, fun, rides, shopping and entertainment.

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Sep 17 • 6:35 PM EDT • Entertainment • facebook.com
Health department holds community baby shower for Lynchburg

It’s one of a series of showers that’s part of the Virginia Department of Health’s “Beyond the Blues” campaign.

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Sep 17 • 5:34 PM EDT • Health • wdbj7.com
Detroit Free Press

Abdul El-Sayed takes on politics, Islamophobia and critics in Jewish, Black communities in race for U.S. Senate seat. See link below ⬇️ 📸 Ryan Garza, Detroit Free Press

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Sep 17 • 2:39 PM EDT • Politics • facebook.com
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Your Entertainment Escape – Aztec Batman: Clash of Empires – YourCentralValley.com

The latest videos from YourCentralValley.com | CBS47 and KSEE24

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Sep 17 • 10:55 AM EDT • Entertainment • yourcentralvalley.com
Redistricting moved 1 in 10 Americans into a new House district, report finds

A new report reveals that mid-decade redistricting for the U.S. House has changed congressional districts for one-tenth of Americans.

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Sep 17 • 6:21 AM EDT • Politics • news4jax.com
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Scientists find youngest exoplanet on record

That's one big baby.

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Sep 17 • 6:00 AM EDT • Science • space.com
Crews respond to structure fire at Ocala manufacturing business

Ocala Fire Rescue crews responded to a structure fire Wednesday at a manufacturing business, according to officials.

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Sep 16 • 11:34 PM EDT • Business • wcjb.com
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Study looking into solutions for maternal mental health shortfalls in Nebraska

A recent report shows Nebraska is behind on providing mental health support for new mothers. A study is now looking into what’s behind the problem.

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Sep 16 • 8:22 PM EDT • Health • wowt.com
Suffolk BOE dodges political intrigue

Longtime county chair Rich Schaffer is being challenged by Southold Town party chair Kathryn Casey Quigley with a vote set for Tuesday.

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Sep 16 • 6:13 PM EDT • Politics • newsday.com
More than 200 jobs eliminated from Health First in Brevard County

Health First has notified over 200 associates that their positions are being eliminated, according to a release issued on Wednesday.

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Sep 16 • 5:52 PM EDT • Health • clickorlando.com
More than 200 associates fired from Health First in Brevard County

Health First has notified over 200 associates that their positions are being eliminated, according to a release issued on Wednesday.

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Sep 16 • 5:52 PM EDT • Health • clickorlando.com
Omaha sports bar owner honors sister’s memory during Nebraska-Creighton volleyball match

Owner says demand for spaces to watch women’s sports continues to grow.

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Sep 16 • 3:29 PM EDT • Sports • wowt.com
Sports entertainment career expo planned during Smith-Jones basketball excursion

The Smith-Jones Family Foundation is organizing a Sports Entertainment Career Expo during its Nov. 4 pro basketball excursion to Detroit. Youths 16 and younger can learn about careers in the sports entertainment industry while attending the 76ers-Pistons game and participating in special activities.

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Sep 16 • 2:34 PM EDT • Entertainment • hometownstations.com
Boston 25 News

The fan-favorite fair in West Springfield is returning this weekend for 17 days of food, fun, rides, shopping and entertainment.

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Sep 16 • 2:20 PM EDT • Entertainment • facebook.com
North Carolina’s Southeast welcomes new Director of Business Development Savannah Taylor

Savannah TaylorSavannah Taylor, a career economic development professional, has accepted the role of director of Business Development at North Carolina’s Southeast. She officially started in the position on Sept. 14.“North Carolina’s Southeast’s success has long been based on strategic collaborative engagement and leadership among our team and with our partners, so a key aim was to find someone who aligned with those dynamics,” said NCSE President Steve Yost in a press release. “Savannah has strong experience for this position through her previous roles in local economic development, research, and policy development, and it became clear that she would be an excellent match in helping to advance the mission for our 20-county region. We couldn’t be more excited to welcome her to the Southeast.”Before joining the Southeast team, Taylor lived and worked in Georgia as an economic development project manager for the City of Marietta and as public policy & research manager and research director for the Georgia Chamber of Commerce Foundation. She has successfully led public policy and strategic project initiatives related to statewide community development and has served on several special committees, including the Metro Atlanta eXchange for Workforce Solutions Research Committee and the United for ALICE Georgia Research Advisory Committee. “After previously working at the state and local level in Georgia, I knew I was looking for a local or regional organization as my next step,” said Taylor in a press release. “I wanted to find a highly collaborative environment, and that led me to North Carolina’s Southeast.”Taylor graduated from Georgia College & State University with dual degrees — a B.S. in Economics and a B.A. in World Languages and Cultures. “I’m really looking forward to interacting with the organization’s partners and all of the local developers,” said Taylor in a press release. “Overall, I think I’m most excited for the new adventures with all the hiking and biking and everything else there is to explore in the region. I hope if anyone has any recommendations, they’ll share them!”

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Sep 16 • 9:38 AM EDT • Business • bizfayetteville.com
FilmOne Entertainment becomes Nigeria's sole representative among six African buyers at TIFF's new market

#FeaturedPost

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Sep 16 • 8:13 AM EDT • Entertainment • africa.businessinsider.com
Trump taking notes from India? US$5,000 cash pitch draws ‘freebie’ comparisons

Indian politicians and commentators accuse the US president of mimicking South Asia’s election playbook to woo voters ahead of the midterms.

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Sep 16 • 8:00 AM EDT • Politics • scmp.com
Congress races to stake out positions on AI

The fast-moving technology represents a rare thing in American politics: a policy arena where the entrenched political parties don’t yet have calcified positions.

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Sep 16 • 12:01 AM EDT • Politics • bostonglobe.com
RenCen redevelopment seeks $548M in public incentives on $2.24B project

In all, the incentives amount to about 24.3% of the project cost, or roughly $1 out of every $4 spent.

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Sep 15 • 6:00 PM EDT • Business • crainsdetroit.com
Is having a ‘gut feeling’ real? What science says about your microbiome

Ever wonder if a "gut feeling" is actually real? Science says yes. Your gut is home to trillions of microbes that play a huge role in both your physical and mental health.

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Sep 15 • 5:19 PM EDT • Science • kplctv.com
Tuchel regrets not eating Azteca turf after win over Mexico

Thomas Tuchel regrets not eating any of the grass at the Azteca Stadium after England's epic World Cup win against Mexico.

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Sep 15 • 3:25 PM EDT • Sports • sports.yahoo.com
Family-owned Ferndale grocery expanding to Bloomfield

Western Market's new location will focus on prepared foods while still offering locally sourced groceries.

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Sep 15 • 9:20 AM EDT • Business • crainsdetroit.com
Chelan County Sheriff's Office

This National Co-Responder Week, we recognize and thank our Behavioral Health Unit (BHU) for the work they do every day, alongside patrol and throughout the year. Their partnership brings together...

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Sep 14 • 3:58 PM EDT • Health • facebook.com
Ballots set to be mailed to overseas Oregonians this week

Ballots will be mailed to overseas Oregonians on Friday, all while the Trump administration continues to try and restrict mail-in voting.

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Sep 14 • 9:00 AM EDT • Politics • opb.org
A business leader’s guide to rising political risk in the US

Deborah McNamara is executive director at ClimateVoice The Trump administration is a threat to free and fair elections, the rule of law, civil liberties and rights, and an independent press — and authoritarianism is bad for business

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Sep 13 • 8:00 PM EDT • Business • sustainableviews.com
A business leader’s guide to rising political risk in the US

Deborah McNamara is executive director at ClimateVoice The Trump administration is a threat to free and fair elections, the rule of law, civil liberties and rights, and an independent press — and authoritarianism is bad for business

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Sep 13 • 8:00 PM EDT • Politics • sustainableviews.com
UK PM Burnham to meet business leaders to discuss growth

British Prime Minister Andy Burnham will meet the bosses of several major ​companies on Monday to discuss his ‌plans to generate economic growth, his office said.

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Sep 13 • 5:32 PM EDT • Business • reuters.com
NASA astronaut Jessica Meir shares zero-G curly hair tips from the ISS (video)

I was once an analog astronaut, and I also have curly hair, so this hit home for me.

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Sep 13 • 10:00 AM EDT • Technology • space.com
'Antigone' review: Sophocles tragedy transposed to Aztec Empire

The Getty Villa production of Evelina Fernández's 'Antigone: In the Language of Kings," co-produced by Latino Theater Company, resets Sophocles tragedy to pre-conquest Tenochtitlan, Mexico.

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Sep 11 • 1:35 PM EDT • Entertainment • latimes.com
GitLab CVSS 10 File-Read Flaw Draws In-the-Wild Probes After Disclosure

GitLab patched CVE-2026-85706, a CVSS 10 path traversal flaw enabling unauthenticated file reads, as in-the-wild probes began.

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Sep 11 • 12:30 PM EDT • Technology • thehackernews.com
Microscopic fragments of ancient alien tech may litter the moon — and scientists have a plan to find them

Researchers propose that tiny technological remnants left over from extinct alien civilizations could have landed on the moon after traveling through interstellar space. It may not take long to find them, the team claims.

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Sep 11 • 11:29 AM EDT • Science • livescience.com
40K views · 208 reactions | 'HOW WE DO SCIENCE IN SPACE' Astronaut...

'HOW WE DO SCIENCE IN SPACE' Astronaut Anil Menon explained how they conduct ultrasound screening while on board the International Space Station. "Microgravity changes the normal flow of blood and...

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Sep 11 • 4:44 AM EDT • Science • facebook.com
Fyffe gets state grant to prepare industrial park for new business

Fyffe received more than $40,000 through a state grant to help prepare its industrial park site for businesses looking to move in.

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Sep 10 • 4:47 PM EDT • Business • waff.com
Kings of Leon reveal a new more personal, acoustic songwriting direction with album 'O My Beloved'

Kings of Leon are returning with a new album, “O My Beloved,” which marks a sonic shift for the band.

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Sep 10 • 11:01 AM EDT • Entertainment • ksat.com
Anomaly Insights, Inova Health partner on AI-powered RCM

Artificial intelligence-powered payer intelligence startup Anomaly Insights announced Thursday a collaboration with Inova Health to improve payment outcomes and support revenue management operation | Through the partnership, Anomaly will provide Inova with additional data and analytics to evaluate payer behavior and payment outcomes.

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Sep 10 • 9:00 AM EDT • Health • fiercehealthcare.com
For these Midwest farmers, regenerative agriculture is about more than soil health. It's spiritual

A farmer in Minnesota has transformed a conventional farm using both formal agricultural education and the Indigenous wisdom he learned as a youth growing up in the Guatemalan rainforest.

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Sep 10 • 7:03 AM EDT • Health • newsday.com
Marquette gets $8 million planned gift for scholarships, business and athletics

Marquette University has received an $8 million planned gift from alumnus and longtime university volunteer Jim Meier, with the money earmarked for

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Sep 9 • 11:59 PM EDT • Business • biztimes.com
Apple launches iPhone 18 Pro with upgraded camera

Apple's new iPhone 18 Pro lineup upgrades the camera and comes in burgundy.

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Sep 9 • 1:26 PM EDT • Technology • techcrunch.com
Federal health officials warn Nashville hospital risks losing Medicare deal

Federal health officials are warning Ascension Saint Thomas Hospital that it must quickly fix serious patient-safety problems or risk losing Medicare.

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Sep 9 • 9:56 AM EDT • Health • fox17.com
Baptist Health Corbin encourages community to get flu shots, offers appointment-free vaccinations

Baptist Health is reminding people of the importance of an annual flu shot and of opportunities to get vaccinated.

wkyt.com logo
Sep 9 • 9:52 AM EDT • Health • wkyt.com
DIA to open first Georgia O’Keeffe exhibit devoted to famed artist’s architectural paintings

The Detroit Institute of Arts expects the show will draw 125,000 or more visitors at $20-$30 per ticket.

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Sep 9 • 5:45 AM EDT • Entertainment • crainsdetroit.com
Entertainment Agency Rep, Journalists in 3 Billion Won Stock Probe

Entertainment Agency Rep, Journalists in 3 Billion Won Stock Probe Authorities probe front-running scheme, 300 stocks, 3 billion won illicit gains

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Sep 9 • 3:20 AM EDT • Entertainment • chosun.com
Supreme Court rejects Missouri's push to use new Republican-drawn U.S. House map in November

Missouri's new districts were used in the August primaries, but the Missouri Supreme Court ruled in September that the state must revert to districts adopted after the last census.

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Sep 8 • 6:07 PM EDT • Politics • pbs.org
Moment of Science: Abundant oxygen not enough to explain massive ancient insects, new study suggests

Unlocking answers about giant ancient insects! Here's why an abundance of oxygen 300 million years ago may not explain why some animals got so gigantic after all.

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Sep 8 • 3:40 PM EDT • Science • 13abc.com
AZ's R&D chief Barr touts internal 'science success story' after IL-33 antibody's stellar showing in COPD

With a detailed data drop that AstraZeneca’s R&D chief described as an internal “science success story,” the British Big Pharma has secured an FDA priority review for what it believes could become a flagship biologic in chronic obstructive pulmonary disease (COPD). In detailed results from the late-stage Oberon and Titania trials—first teased in March and detailed in full at the European Respiratory Society Congress in Barcelona this week—the drugmaker laid out the extent of its IL-33 inhibitor’s potential to reduce moderate and severe exacerbations in a wide range of COPD patients still struggling with those “lung attacks,” as AstraZeneca’s Sharon Barr, Ph.D., called them, despite using standard-care inhaled therapy. In the headline results, a 300 mg dose of tozorakimab given once every four weeks curbed those moderate and severe exacerbations in the studies’ primary population of former smokers by 29% in the Oberon study and 34% in Titania. In the overall population of both current and former smokers, these reductions were 30% and 29%, respectively, versus placebo and inhaled standard of care. The benefits also extended to clinically meaningful exacerbation reductions in all prespecified patient subgroups and specifically turned up promising signals in patients across a range of blood eosinophil counts, with Barr telling Fierce that “it’s the details that make this even more exciting than the high-level results that we’ve already shared.” In fact, during AZ’s tozorakimab poster presentation at the ERS 2026 Congress this past weekend, attendees were so enamored by the data that event organizers had to encourage people to clear the room and look at the other presentations on offer, Barr said in an interview. “I think it really speaks to the fact that there is a lot of buzz around these data because the entire respiratory community has been so desperate for new therapies for these patients,” she explained. The respiratory disease continues to represent a “staggering unmet medical need,” Barr said, highlighting the COPD exacerbations that the Oberon and Titania studies homed in on, which she added carry a greater mortality risk than a heart attack. “When a patient has a severe exacerbation, only about half of them are still alive within three and a half years,” she pointed out. As for tozorakimab specifically, Barr christened the molecule “an AstraZeneca science success story,” harkening several years back to the point at which researchers began to explore IL-33 as a driver of respiratory disease, and COPD in particular. At the same time, “there was still so much that wasn’t understood,” she admitted, highlighting the insight that IL-33 signals through both ST2 and EGFR through the RAGE pathway, a discovery Barr attributed to AstraZeneca's own scientists. Understanding the need to tackle both pathways in COPD—and aware of competitor candidates in the hopper, including one that bound ST2—the company ultimately had to make some “courageous decisions,” Barr said. These included taking a prior COPD molecule offline and going back to the drawing board to reinvent its potential IL-33 label “to make sure that we had a molecule that could block signaling through both arms of the pathway, through both the reduced form and the oxidized form, knowing that we wouldn’t be first, but striving to be best.” “When we put [tozorakimab] into the clinic, we firmly believed that we had a differentiated molecule, and we saw the other molecules blocking just ST2 or partially blocking IL-33, unable to deliver two positive pivotal studies in COPD,” Barr explained. “We kept marching forward because we believed our molecule was differentiated, and now I think we have the clinical validation that supports that.” Ultimately, AstraZeneca finds itself on much better footing these days when it comes to potential biologic rivals to tozorakimab in COPD. Sanofi and Regeneron’s Dupixent, for instance, is approved to treat COPD exacerbations in patients with high eosinophil counts, but not low ones. Meanwhile, the future has become cloudier for other next-gen IL-33 candidates from Sanofi and Regeneron, as well as Roche, which have suffered trial flops in recent years. One other potential ingredient for AstraZeneca’s success in its duo of studies was that the company was “ambitious in the trial design, willing to look at an all-comers population,” Barr said, “and willing to enroll the most severe patients.” Prior studies for would-be biologics rivals in COPD “avoided enrolling” those patients, she pointed out. She also highlighted the Big Pharma’s painstaking design of exacerbations in its trial, which “gave us a very rigorous readout,” and pointed to “the extra effort and investment” the company put in to understand the effect of mucus plugs in patients. Barr described mucus production as a “key feature in disease diversity,” noting that mucus plugs—obstructing clumps of mucus that block patients’ airways—are associated with worse outcomes in COPD. In its data announcement, AstraZeneca noted that an integrated analysis of Oberon and Titania found tozorakimab “demonstrated a reduction in patients’ mucus plug score,” with the pharma claiming its biologic is the first to deliver such results in a broad COPD population. “So being able to reduce those mucus plugs, we expect, is an important part of driving benefit for patients who are living with COPD,” Barr said. Again touching on the breadth of the study populations, Barr added that tozorakimab “worked across all eosinophil levels in both current and former smokers across all levels of lung function,” which she suggested “really simplifies decision-making for clinicians, and it allows them to offer therapy to the broadest possible patient population.” In the highest patient eosinophil count group, tozorakimab helped chart a 43% reduction in exacerbation risk, which Barr stressed were “unprecedented data.” In the mid-level group, AZ’s drug delivered a 23% reduction and, in the lowest group, a 34% reduction in eosinophils, which Barr said suggests efficacy “in all patient subgroups.” As for AZ’s recent guidance upgrade on the medicine’s sales opportunity, the lift from a $3 billion to $5 billion range to $5 billion plus was informed by multiple factors, Barr said, including the fact that “in 2024, there were multiple competitors, and there aren’t anymore.” Additionally, “we know that this is a massive unmet medical need, and this is a really incredible set of data that we think will be very convincing to the clinical community,” Barr said. Looking ahead to a potential evolution of the COPD treatment landscape, Barr noted that most patients start treatment in the community with an option like a triple therapy, and for them, having an option like AstraZeneca’s inhaler Breztri will remain a “really important part” of that journey. But of the patients uncontrolled on triple therapy, which Barr described as “about half of them today,” just a “small fraction” are currently eligible for biologic therapy, which she emphasized AstraZeneca is working to change. Understanding that COPD is not a “one-size-fits-all” disease, AstraZeneca is also looking at its antibody drug Tezspire for patients with T2-driven disease, and the company continues to think about new mechanisms for tackling COPD through both systemic and inhaled drugs, Barr said.

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