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Kings HC Christie 'Really Enjoying' FA Signing Simmons
The Sacramento Kings are hoping free agent pickup Ben Simmons can get back to a semblance of his old self, while giving the team a much-needed boost on the defensive end. Head coach Doug Christie has been extremely positive regarding Simmons, calling him a "special" player.
Carnell Tate Not Letting First-Half Blunder Ruin Historic Day
The rookie receiver overcame a costly turnover to deliver a dominant 145-yard performance, signaling a new era of offensive consistency for Tennessee despite a narrow loss.
NWA C-Suite: Sam Sicard
Since taking the helm at the age of 35, Sicard has grown assets from $1.5 billion to $3.5 billion. He has also expanded the company’s footprint into eastern and southwestern...
Pokémon GO Halloween 2026: Part One
Pokémon GO’s Halloween 2026 Part One event runs from October 27 at 10:00 a.m. to November 1 at 10:00 a.m. local time, bringing three new costume Pokémon: Pikachu wearing a hat and capelet, Zubat wearing a top hat, and Sinistea wearing a bow! Expect spooky wild encounters, costume raids, and trick-or-treat surprises that can reward […]
Business Insider expands Discourse team and hires Arielle Pardes
Our Discourse team, led by executive editor Zak Jason and focused on agenda-setting topical features, is expanding.
Houston high school football: Week 6 takeaways and top performers
Landen Williams-Callis is passing Texas high school football legends, Friendswood is off to its best start in 16 years, Bridgeland is surging toward another district title run.
Greenfield Business Association distributes inaugural Buzz Awards
Greenfield Business Association held its first Buzz Awards at Four Phantoms Brewing Co., celebrating local shops like Hope & Olive and Freedom Cafe.
Mental health stigma in Japan may deter care
A UC Riverside–led study of mental health stigma in Japan has found a striking gap between the need for treatment and people's willingness to seek it, with high levels of social distancing toward people ...
Top Iranian official admits dire state of the economy: Report
A top Iranian official reportedly admitted that Iran’s economy is in dire straits due to the war and the U.S. blockade of the country. Mohsen Rezaei, secretary of the Supreme National Security Council and former commander in chief of the Islamic Revolutionary Guard Corps, made the admission Saturday at a high-level government meeting focused on […]
Lewis Ginter Botanical Garden cancels health coverage for striking employees
Striking employees of the Lewis Ginter Botanical Garden are being removed from the nonprofit's healthcare plan, according to a letter from the garden. Lewis Ginter wrote to CBS 6: "The law does not require employers to continue paying wages or unaccrued benefits to striking workers who are not actively
God Packs are Officially Coming to Magic: The Gathering
Magic: The Gathering booster packs have gone through a lot of changes in the last decade, some of which have been awful. But Wizards of the Coast are introducing 'God Packs' to MTG, which could feel like winning the lottery.
Serie A talent in Golden Boy Award 2026 nominees
The nominees for the 2026 Golden Boy Award have been announced, including Serie A talent Kerim Alajbegovic of Juventus, Roma’s Rodrigo Mora and Franco Mastantuono of Fiorentina.The trophy is for the...
49ers’ Mike Evans Reveals Truth About Playing Through Rib Injury
Mike Evans was not expected to play this week. He suited up anyway. The San Francisco 49ers receiver played through a painful rib injury in a 24-14 win over the Denver Broncos. Evans Beats the Odds for the 49ers Evans hurt his ribs in Week 3 against the Arizona Cardinals. Many assumed he would miss […] The post 49ers’ Mike Evans Reveals Truth About Playing Through Rib Injury appeared first on HEAVY.
#TenYearsAgo in Health Law - Petrie-Flom Center
Since January 2026, the “10 years ago” viral trend on social media — fueled by nostalgia and literal rose-colored glasses (ok, filters) — has tried to remind us of the allegedly simpler times of 2016.
RWJBarnabas Health President and CEO Mark E. Manigan Named 2026 NJBIZ Executive Excellence Honoree
Mark E. Manigan, President and Chief Executive Officer of RWJBarnabas Health, the largest, most comprehensive academic health system in New Jersey, has been named a 2026 Executive Excellence honoree by NJBIZ, recognizing his leadership and impact on New Jersey’s health care landscape. Mr. Manigan and the other honorees will be recognized by NJBIZ at an awards ceremony taking place today.
ASU designs a statewide pipeline for Arizona's anesthesia workforce
Every surgery, C-section, trauma case and cancer operation in Arizona depends on a clinician administering anesthesia and keeping the patient safe while the surgeon works. The state needs more of these clinicians.As of September, the Arizona State Board of Nursing lists 1,759 certified registered nurse anesthetists, or CRNAs, in the state. In 2023, Arizona was short 732 nurse anesthetists, and the shortage is projected to reach 868 by 2033.
After school programming, birthday parties and day camps at Brooklyn Science Spot in Carroll Gardens (sponsored) | Brooklyn Bridge Parents - News, Events and Family Services
Brooklyn families, get ready for a fall experience that goes beyond worksheets, screen time, and ordinary after-school programs and camps. At Brooklyn Science Spot, we are opening the door to a whole new way for children to learn, explore, and fall in love with science through hands-on discovery, creative thinking, and real-world STEM fun. Opening
Stock up/stock down for Kentucky after beating South Carolina
The Kentucky football team got a comeback win over South Carolina this week. Here's whose stock is soaring, and whose isn't afterwards.
‘Primetime’: Is catching predators justice or just entertainment?
Rating: ★★★½ Starring Robert Pattinson, Skyler Gisondo, Merritt Wever Directed by Lance Oppenheim Rated R Release Date: Sept. 25, 2026 A man waits unknowingly inside a sting house. His eyes draw up to the sound of curtains ruffling as Chris Hansen (Robert Pattinson), host of Dateline NBC’s “To Catch a Predator,” enters flamboyantly. Hansen descends...
Philanthropy: Q+A with William Ahmanson
William Ahmanson is the president of the Ahmanson Foundation, which financier Howard F. Ahmanson and his wife, Dorothy Grannis Ahmanson, established in
Pat Bryant catches all three targets
Denver Broncos WR Pat Bryant (ankle) caught all three of his targets for 47 yards in Week 4 before exiting with an ankle injury.
Celebrity birthdays for the week of Oct. 11-17 include Cardi B and Dominic West
Celebrities having birthdays during the week of Oct. 11-17 include rapper Cardi B, “The X-Files” creator Chris Carter and “The Wire” actor Dominic West. Rapper Eminem turns 54, singer Sammy...
Caring for students a priority at Health Center
A primary purpose of the Campbell University Health Center is caring for students, serving as an important resource in regard… More on this post
Courtland Sutton with another dreadful day
Denver Broncos WR Courtland Sutton had just one catch for four yards on six targets in Week 4.
Nobel medicine prize goes to 3 scientists for research into brain activity
The Nobel Prize in medicine has been awarded to three scientists whose work led to a tool that uses light to help unravel how the brain works
Silly Dillys Wins $30,000 at RISE Up Harlingen Business Pitch Competition
Silly Dillys captured first place and a $30,000 award at the third annual RISE Up Harlingen Business Pitch Competition, leading a group of local entrepreneurs receiving financial support to develop and expand their businesses.
Spurs employ three-guard lineup during Silver & Black Scrimmage
De'Aaron Fox, Stephon Castle and Dylan Harper played together in what coach Mitch Johnson called "on-the-job training."
FSU data scientist receives NSF CAREER Award to develop AI model to analyze complex numerical data at scale
A Florida State University artificial intelligence and data scientist has earned one of the most prestigious early career faculty awards to develop a new
Jaylen Waddle scores first TD
Denver Broncos WR Jaylen Waddle had five catches for 35 yards and a touchdown in Week 4.
Capitals’ Alex Ovechkin suddenly announces retirement plans
The 41-year-old forward has the end in sight.
🚨 Golden Boy 2026: the official list of 25 finalists
The whiz kids.From 100 to 25. On Monday evening, the official list of 25 finalists for the 2026 Golden Boy award was unveiled by Italian sports outlet Tuttosport, which organizes the event and the awa...
Businesses Finding It Harder to Predict AI Spending
Companies are reportedly finding it increasingly difficult to forecast their AI spending. That’s according to a report Monday (Oct. 5) by The Wall Street
RJ Harvey leads team in receiving
Denver Broncos RB RJ Harvey had 10 catches for 68 yards, which led the team in both categories in Week 4.
[LEAKED] Dream Harvard Business School Invitee List
[LEAKED] Dream Harvard Business School Invitee List
3 scientists share Nobel Prize in Physiology and Medicine for work in optogenetics
The Nobel Foundation awarded its prize in physiology and medicine Monday to three scientists who researched how nerve cells affect the brain.
Seedy K’s Pigskin Palaver: House of Cards & Much Mo’
Ah yes, October; the pigskin campaign is morphing more fully developed. And, fully enveloping. This week, there’s a football game on every single night. Not just the more traditional Thursday, Friday, Saturday, Sunday, Monday. Because Draft Kings and Fan Duel and The World Wide Leader need content, we get Southern Miss and Troy on Tuesday, […]
What does Spain's snap election mean for the EU?
Spain's snap election on 29 November could cost progressive European forces their last government in a large member state, tilting EU power towards the right and pushing socialists into opposition mode.
Paid influencers and political ads - Illinois Times, the capital city's source of news, politics, arts, entertainment, culture
My associate Isabel Miller and I worked on a story last week about paid influencers in campaigns. We decided to look into it after reading news reports about how the Chicago Teachers Union has been using paid influencers in its battle to control the elected Chicago school board and Chicago Mayor Brandon Johnson is also […]
Supreme Court rejects Roy Moore's push to restore $8.2M defamation verdict awarded to him
The U.S. Supreme Court has rejected Roy Moore’s push to restore an $8.2 million defamation verdict awarded to him over a 2017 Senate ad | KNSS Radio
Nobel for medicine awarded to 3 scientists for work that helps map the brain
A method that controls nerve signals with light, developed by an American and two Germans, has provided greater understanding of Alzheimer’s and is used in efforts to restore sight.
Spurs' Harris questionable for regular-season opener after straining left calf
The 6-foot-8 power forward will be reevaluated following the team’s five-game preseason schedule.
CARTI encourages women to prioritize breast health
As part of its annual breast health campaign, CARTI Cancer Center shared critical information regarding the importance of early detection and debunked common misconceptions about breast cancer risk…
Sony introduces AI upscaling to base PS5; Marvel's Wolverine and Ghost of Yōtei are first games to implement new tech
PlayStation Spectral Super Resolution (PSSR) remains exclusive to the PS5 Pro, which SIE says is the "gold standard"
2026 Outstanding Women in Business
The 18th annual Outstanding Women in Business awards recognize a dozen well-accomplished professionals from across the region and in many industries who go above and beyond. The committee selected the winners from more than 80 nominations, all of whom were worthy. The criteria evaluated each nominee’s professional achievements, community impact, ability to break the glass ceiling and mentorship of other professionals, particularly women. In addition to profiling these women in the following pages, the Worcester Business Journal will celebrate this year’s Outstanding Women in Business at a special luncheon on Oct. 28 at the College of the Holy Cross. To join the celebration of these exceptional women, visit WBJournal.com and register. – Mark Conti, editor This Year’s Judges Worcester Business Journal considered 54 Central Massachusetts professionals for the 2026 Outstanding Women in Business awards, based on 83 nominations. These nominees were independently evaluated by two volunteer judges, who scored each on their professional achievements, community contribution and mentorship of young professionals. Samantha P. McDonald is a partner at Bowditch. She is an experienced, client-focused real estate lawyer, concentrating on business and real estate property law. She has been recognized as a WBJ Power 100 in the Class of 2026 and a “Top Women of Law” in Massachusetts Lawyers Weekly. Dr. Kavita Babu is chief medical officer and vice president of medical affairs at Heywood Healthcare, where she provides strategic and clinical leadership to advance high-quality, patient-centered care across the organization. She is also a member of the WBJ Outstanding Women in Business Class of 2025.
NFL looking into an official cursing at Cardinals tight end Trey McBride
Line judge Jeff Seeman was caught on camera cursing at McBride, which drew the ire of union leader JC Tretter
Michael Douglas on 'immortality,' Kirk Douglas and the memories he once avoided
Michael Douglas, the award-winning actor and producer, recently turned 82 and has released a memoir titled “One Helluva Ride.” | 830 WCCO
Michael Douglas on 'immortality,' Kirk Douglas and the memories he once avoided
Michael Douglas, the award-winning actor and producer, recently turned 82 and has released a memoir titled “One Helluva Ride.” | WWJ Newsradio 950
Labour standards increasingly shape market access and business competitiveness
A new ILO Brief examines how labour standards and responsible business expectations are increasingly shaping market access, supply chains and business competitiveness in Asia and the Pacific. It highlights the role of employer and business membership organizations in helping companies navigate evolving requirements and promote better labour outcomes.
DeSean Bishop Is the X-Factor Arkansas Must Contain
Arkansas knows exactly where Tennessee’s offensive plan begins. It begins with DeSean Bishop. The Volunteers running back enters Fayetteville after one of the best performances in the country this season. Bishop rushed 34 times for 220 yards and three touchdowns in Tennessee’s 24-14 win over Auburn, turning a game with quarterback uncertainty into a statement …
Kim Kardashian Says She Has to ‘Hold Back’ North West, but the 13-Year-Old Calls Waiting the ‘Worst’ Advice
Kim Kardashian supports North West’s entertainment ambitions while trying to control how quickly her 13-year-old daughter takes on new opportunities. In a new Sunday Times ... Read More
Detroit Lions vs. Arizona Cardinals Point Spread Revealed
The Detroit Lions are favored on the road against the Arizona Cardinals in Week 5. Check out the latest FanDuel point spread, moneyline and total.
Yankees draw baseball’s hottest September arm in Game 2
The Yankees got one hit Saturday. Their reward for trying to even the series Monday is a starter who allowed […]
Marvel's 'Project COMET' First Gameplay Trailer Allegedly Leaks
We've heard rumors and talk of Project COMET for weeks, and the new Marvel game has reportedly had its first footage leaked.
Grades Reflect Poor Offensive Effort In This Report Card
The Denver Broncos lost by two touchdowns yesterday, and this report card reflects the specifics.
Delta Health Center Receives Funding
Delta Health Center, Inc. has received four awards totaling $4,660,331.59 through the Mississippi Rural Health Transformation Program, a state initiative funded by the Centers for Medicare & Medicaid Services. Governor Tate Reeves announced the four RHTP awards on September 14, as part of 167 awards totaling more than $104 million statewide. The awards announced will […]
Delta Health Center Receives Funding
Delta Health Center, Inc. has received four awards totaling $4,660,331.59 through the Mississippi Rural Health Transformation Program, a state initiative funded by the Centers for Medicare & Medicaid Services. Governor Tate Reeves announced the four RHTP awards on September 14, as part of 167 awards totaling more than $104 million statewide. The awards announced will […]
Stanford Professor One Of Three Scientists Awarded The Nobel Prize In Medicine
Stanford professor Karl Deisseroth joins Peter Hegemann and Georg Nagel as winners of the 2026 Nobel Prize in Physiology or Medicine for their work on optogenetics.
Dan Campbell refuses to talk about Kelvin Sheppard’s job security
Detroit Lions coach Dan Campbell wouldn’t discuss DC Kelvin Sheppard’s job security after another defensive meltdown.
Business confidence held in negative territory in September
Business confidence ticked upwards among Massachusetts employers in September but sentiment remained in negative territory and torn between the impacts of growth and rising costs.
Carlisle boss Elliot proud of squad after hard week
After a five-game winless streak, consecutive away wins have eased some of the pressure on Carlisle head coach Rob Elliot.
Best Buy’s Techtober Sale Is Live with Big Discounts on PS5, Switch 2, and Xbox Games—and Unlike Prime Day, Deals Aren't Locked Behind a Membership
Best Buy's Techtober sale is now live, rivalling Amazon Prime Day with savings on new PS5 game releases, Xbox hardware bundles, and plenty more.
The Daily Mauling: 10/5/26
Kansas Jayhawks News It’s official, Melvin Council, Jr is coming back to Kansas Jalon Daniels got his first NFL start this weekend. It didn’t go especially well, but he vows to use the lessons he learned moving forward What did we learn from the 55-0 drubbing of MTSU? The LJW weighs in The Topeka Capitol-Journal […]
Integral Ad Science to Provide Brand Safety and Suitability Measurement in ChatGPT Ads
NEW YORK, October 05, 2026--As artificial intelligence rapidly reshapes digital advertising, marketers face a critical new challenge: ensuring brand safety and suitability within dynamic, generative AI-native environments. Without independent verification, advertising in conversational channels risks creating a blind spot for enterprise brands seeking reliable media quality standards.
Physician Assistant Brandon Guth Earns Reid Health’s Advanced Practice Provider of the Year Award
Brandon Guth, PA-C, a physician assistant with Reid Medical Associates, is the second recipient of Reid Health’s Advanced Practice Provider (APP) of the Year Award for his commitment to clinical …
Providence Opens New Rural Health Clinic in Polson
Just over a year after breaking ground on a rural health clinic in Polson, community members, donors and hospital staff gathered Sept. 30 in front of the new building just behind Providence St. Joseph Medical Center. “Over the years we’ve heard about this need over and over again,” Chief Executive for Providence Montana Krissy Petersen […]
Medicare-for-all is back. Now comes the hard part.
Democrats are reviving an old idea. Now they have to define it and pay for it.
Lions vs. Cardinals odds: Opening lines for Week 5 matchup
Checking in on the opening betting odds for the Week 5 matchup between the Detroit Lions and the Arizona Cardinals.
Walworth County dairy farmer specializing in raw milk says state is unfairly fining his business
Chaz Self said his dairy farm is producing grade A milk under Wisconsin's state standards, but was still ordered to pay a hefty fine. An online fundraiser has been created to cover those fines.
Nobel medicine prize goes to 3 scientists for research into brain activity
The Nobel Prize in medicine was awarded Monday to three scientists working on the mechanisms the brain uses to switch on, or off, the activity of individual nerve cells.
Florida commissioner’s social media on science standards aims for attention
A roundup of Florida education news from around the state
Florida commissioner’s social media on science standards aims for attention
The big story: When Henry Mack III became Florida’s education commissioner in the summer, public education advocates expressed high hopes for the positive way he kicked things off with school official...
Jobs in health care. Jobs for women. The US labour market is segmenting. Chernobyl’s radiation and Lenin’s love of literature.
Thank you for opening your Chartbook email. Elmer Bischoff, Two Figures at the Seashore, 1957 The only really dynamic job-creator in the US economy is health care: The largest crunch has come in Federal government, which has shed 2.7 m jobs. Source: tchouvkov on Twitter Tech is struggling. [ Joey Politano 🏳️🌈@JosephPolitano The US tech sector continues bleeding jobs in official data released today—overall, employment decreased by 17k last month and is down 69k over the last year That's nearly as bad as the worst of the 2024 tech-cession, and much worse than the 2022 boom or even pre-2020 norms 12:42 PM · Oct 2, 2026 · 15.2K Views 15 Replies · 47 Reposts · 390 Likes ](https://x.com/JosephPolitano/status/2106001807847940232?s=20) The new jobs are all for women. [ Justin Wolfers@JustinWolfers I'm not sure who saw this coming, but so far nearly all the jobs created during the second Trump administration have gone to women. 1:09 PM · Oct 2, 2026 · 33K Views 70 Replies · 146 Reposts · 644 Likes ](https://x.com/JustinWolfers/status/2106008723533533601?s=20) Meanwhile, real wages are being eaten up by modest over-target inflation. [ Heather Long@byHeatherLong The financial pain is real: Wage growth fell to 3% (y/y) in September. That's the lowest in 5 years. Wage growth: 3% Inflation: ~3.4% Inflation has eaten up all wage gains for the average worker since April. Many people are having to make hard choices about what to buy and what … 1:24 PM · Oct 2, 2026 · 37K Views 24 Replies · 275 Reposts · 533 Likes ](https://x.com/byHeatherLong/status/2106012367712620728?s=20) HEY READERS, THANK YOU for opening the Chartbook email. I hope it brightens your day. I enjoy putting out the newsletter, but tbh, what keeps this flow going is the generosity of those readers who clicked the subscription button. If you are persuaded to click, please consider the annual subscription of $60. It is both better value for you and a much better deal for me, as it involves only one credit card charge. Why feed the payments companies if we don’t have to. Subscribe Elmer Bischoff, Bathers, 1960 Americans are disillusioned with higher ed. For contributing subscribers only. Subscribe Where the Chernobyl radiation went. h/t Simon Kuestenmacher aka simongerman600 How Lenin’s love of literature shaped the Russian Revolution - Tariq Ali This, then, was the intellectual atmosphere in which Lenin came of age. His father, a highly cultured conservative, was the chief inspector of schools in his region and much respected as an educationalist. At home, Shakespeare, Goethe and Pushkin, among others, were read aloud on Sunday afternoons. It was impossible for the Ulyanov family – “Lenin” was a pseudonym adopted to outwit the tsarist secret police – to escape high culture. At high school, Lenin fell in love with Latin. His headteacher had high hopes that he might become a philologist and Latin scholar. History willed otherwise, but Lenin’s passion for Latin, and taste for the classics, never left him. He read Virgil, Ovid, Horace and Juvenal in the original, as well as Roman senatorial orations. He devoured Goethe during his two decades in exile, reading and rereading Faust many times. Lenin put his knowledge of the classics to good use in the time leading up to the October revolution of 1917. In April of that year, he broke with Russian social-democratic orthodoxy and, in a set of radical theses, called for a socialist revolution in Russia. A number of his own close comrades denounced him. In a sharp riposte, Lenin quoted Mephistopheles from Goethe’s masterwork: “Theory, my friend, is grey, but green is the eternal tree of life.” Source: The Guardian Elmer Bischoff, The River, 1953 If you’ve scrolled this far, you know you want to click: Subscribe
Yale School of Medicine On the Science of Childhood Anxiety, Say, Anxiety Disorders Are the Most Common Mental Health Challenges In Youth
Credit: Matt Bradbury October 5, 2026 - By Isabella Backman - Anxiety disorders are the most common mental health challenges in youth. Left untreated, they can disrupt the lives of both children and their families. The good news is that with intervention, most children will overcome these conditions. Across Yale School of Medicine, scientists are working to understand anxiety at every level, from common anxious behaviors to molecular biomarkers in the brain. They are using their findings to develop and disseminate new evidence-based treatments for childhood anxiety. Today, the go-to treatment for childhood anxiety disorders is cognitive behavioral therapy (CBT). This is a form of psychotherapy that teaches children skills for confronting anxious thoughts and helps them practice managing situations that cause anxiety. While it is the gold-standard treatment backed by considerable scientific evidence, up to 50% of children will not see sufficient benefit from CBT alone. Wendy Silverman, PhD, Alfred A. Messer Professor in the Child Study Center, co-directs the Anxiety and Mood Disorders Program alongside Eli Lebowitz, PhD, associate professor in the Child Study Center. One of their main interests is learning how to improve outcomes beyond CBT. “We’re developing cutting-edge, research-based knowledge that can reduce the suffering that anxiety causes children and their families,” says Silverman. Changing parent behavior YSM experts are investigating how to improve CBT outcomes for children by involving the parents. Silverman’s research has uncovered two main components of parent intervention that improve childhood anxiety: not enabling children to completely avoid the things that make them anxious and taking steps to enhance their autonomy. Parents may unintentionally reinforce their child’s anxiety by allowing them to avoid what makes them anxious. They also may unintentionally limit the children’s sense of autonomy by being overly intrusive. “One of the things that we take pride in is that we’ve focused on trying to understand what parents need to do, and to test our ideas and see if changing the parents’ behaviors is enhancing the effects of CBT,” Silverman says. “Our findings thus far suggest that they do." As much as CBT can be helpful, it can also be challenging to get one’s child to do the necessary steps for CBT to work. This is one important reason why Lebowitz created a novel intervention program for parents named Supportive Parenting for Anxious Childhood Emotions (SPACE). Existing intervention programs often teach parents to act as therapists for their child, such as training them on how to practice breathing exercises. “It makes sense, but this doesn’t work very well in practice,” says Lebowitz. “And part of the reason, I think, is that it’s not easy to get your kid to do things, especially if they’re not excited about doing it.” SPACE is unique because it focuses entirely on parent involvement and changing parental behavior—children are not involved in the sessions. For example, parents learn how to use supportive messages that convey confidence that their child can tolerate and manage distress. “It might sound like a parent saying to a child, ‘I get that this is really hard for you, but I know that you can handle it,’” Lebowitz says. The program also works with parents to identify the ways in which they are accommodating anxious behaviors. “We’ll pick one thing that parents are doing that is an accommodation and help them make a detailed plan for how they’re going to change that,” Lebowitz explains. Treating Anxiety in Children and Adolescents Much of the existing research on SPACE has focused on parents of children under age 14. Ongoing studies are now exploring its use with parents of older teens. “Both anxiety and accommodation can interfere with normative developmental shifts during the teen years, including increased autonomy and individuation from parents,” says Rebecca Etkin, PhD, associate research scientist in the Child Study Center. “In this sense, SPACE may be particularly well-suited for anxious teens and their parents. We want to see whether it is effective during this distinct developmental window.” Unfortunately, many families in need of CBT face barriers, including limited availability of services and geographic constraints. One way to improve access is digital interventions. Silverman and her team are developing an evidence-based digitized intervention program for parents that they can access directly from their computer or smart phone. “The work we’re doing will be one of the very few parent interventions that is digitized and importantly tested for effectiveness,” she says. Creating interventions for anxiety-related challenges Silverman and Lebowitz recently received a generous gift to develop and test other interventions that help parents reduce other child anxiety-related behavioral and emotional difficulties, such as restrictive eating and unexplained somatic symptoms. One of these projects in particular focuses on understanding the risks of social media and its potential benefits, including offering a sense of connection. “A lot of research has focused on the idea that social media is harmful and the less of it the better,” says Lebowitz. “But we actually see is that this is not quite right—there are negatives, but there are also positives. So, we’re trying to get a little bit more nuanced of a picture.” The team is working with teens with social anxiety and their parents over an extended period to better understand their social media habits and how their anxiety levels affect engagement with different platforms. The teens will answer questions sent to an app on their phones about mood and social media usage in an effort to capture emotional responses as they unfold. “We hope to develop interventions that can help make the best of social media while protecting against the more problematic effects,” Lebowitz says. The brain’s role in anxiety Researchers are also testing therapies to address anxiety at the neurological and molecular levels. In collaboration with Dylan Gee, PhD, professor of psychology in Yale's Faculty of Arts and Sciences, and Hilary Blumberg, MD, John and Hope Furth Professor of Psychiatric Neuroscience at Yale School of Medicine, Lebowitz and Silverman are using brain imaging to identify changes in a child’s brain before and after parents enroll in SPACE. In one study, children viewed anxiety-inducing images while undergoing magnetic resonance imaging (MRI); the researchers conducted scans with and without the children’s parents nearby. Before SPACE, children’s brains were better able to activate the regulatory circuitry needed to turn off an anxious response when their parents were nearby. But after SPACE, children could activate this circuitry even without the parent around. “As parents work on gradually reducing some of their accommodations, you can see a child get better at regulating their own fear system in the brain,” Lebowitz says. “It’s remarkable.” Research into the molecular underpinnings of anxiety can also inform new childhood anxiety treatments. In a recent study, Lebowitz, Silverman, and Flora Vaccarino, MD, Harris Professor in the Child Study Center, discovered that a protein known as fibroblast growth factor 2 (FGF2) could be protective from the toxic effects of stress. FGF2 levels in children and their parents were linked to the children’s risk of developing anxiety and depression, the study showed. The findings could help explain why some children who are exposed to early life trauma such as poverty or abuse are more prone to developing mental health disorders. And FGF2 could be a target for treatment. “This is very novel because it starts to give a clue to what is the molecular chain that connects those lived experiences to the actual psychological outcomes,” Lebowitz says. New ways to study and treat childhood anxiety Michael Crowley, PhD, associate professor in the Child Study Center, collaborates with Silverman and Lebowitz to study the role that attention plays in development and maintenance of childhood anxiety. There is a large body of research that shows that anxious children, like anxious adults, are prone to focus on threatening stimuli such as angry faces compared with neutral faces. This has led to innovative interventions that involve attention retraining. The idea is that if experts train children to look away from threatening stimuli, it may reduce their anxiety—especially children with social anxiety who are most prone to attend to threats. The researchers have just completed a clinical trial for attention retraining with 10- to 14-year-olds with social anxiety disorders and are currently analyzing the findings. Besides this innovative attention retraining research, as Crowly notes, “I like to design tasks that are engaging to kids,” Crowley says. “My goal is to assess something without the kids knowing what we are assessing.” With this goal in mind, Crowley has created a virtual game, named Boom, to study threat processing in children with anxiety disorders. The game is similar to that of hot potato—the child and three digital players take turns virtually passing a ball to each other’s gloves. At some point, the ball turns into a bomb, and as the bomb lands in each player’s glove, the outline of the glove turns yellow. The goal is to avoid having the bomb go off in your glove. What isn’t obvious is that the game is designed to measure different types of threatening stimuli, both ambiguous and direct. In the game, the direct threat occurs as the bomb is traveling towards your glove. The ambiguous threat is the yellow outlined glove as it is unknown where the bomb will travel next. While children play the game, Crowley’s team measures their brain activity using electroencephalography (EEG). The researchers have discovered that in kids with anxiety, the brain reacts more strongly to ambiguous threats than it does in their peers, but less strongly to direct threats. They believe that the initial abnormally large brain response to not knowing where the bomb is going impairs the brain's ability to properly respond when the threat is actually traveling the child’s way. “The brains of children with anxiety are unable to differentiate between threats you need to do something about and those that are not your problem.” Michael Crowley, PhD, develops innovative games for studying anxiety in children and adolescents.Credit: Matt Bradbury Based on these insights, Crowley hopes to study whether interventions like attention training could restore appropriate threat processing. Crowley’s team is also working on a test called the Balloon Risk Avoidance Task, which evaluates risk-taking and avoidance behaviors. It features a digital balloon that is full of air and about to burst. Kids have six seconds to let air out of the balloon. The more air they let out, the less risk they face that the balloon will pop. But at the same time, the balloon becomes less valuable as it deflates. “The more air you keep in the balloon, the more points you get,” Crowley explains. So far, the researchers have found that when the balloons pop unexpectedly, teens with social anxiety show distinct brain responses. Studying these responses can help psychologists understand the underlying pathways driving the various manifestations of anxiety. The genetics of anxiety When Thomas Fernandez, MD, associate professor in the Child Study Center and of psychiatry, was still in training, there was a lot of excitement about understanding the genetics associated with autism spectrum disorder. Since then, scientists have identified around 250 genes associated with autism. The genetic contribution to anxiety disorders, on the other hand, has historically received less attention. Anxiety is less heritable than autism, but the genetic contribution for anxiety disorders that emerge in childhood may be higher than for anxiety disorders overall. While scientists estimate the heritability of anxiety disorders in general to be around 30% to 50%, some studies suggest higher heritability for certain childhood-onset anxiety presentations. “I saw firsthand how researchers in the field went about finding vulnerability genes for autism,” Fernandez says. “So, we’re using a very similar playbook for childhood anxiety.” “I saw firsthand how researchers in the field went about finding vulnerability genes for autism. So, we’re using a very similar playbook for childhood anxiety.” Thomas Fernandez, MD Associate Professor In the Child Study Center and in Psychiatry Now, Fernandez and Emily Olfson, MD, PhD, assistant professor in the Child Study Center, are studying children and their parents to identify genetic changes that are present in the child but not the parents, known as “de novo mutations.” “All of us have some de novo mutations—maybe about 50 to 100 sprinkled throughout the genome,” Olfson says. “But when they occur within the coding regions of genes, they can be really disruptive.” Previous research shows that people with autism have higher rates of damaging de novo mutations than the general population. In 2022, Olfson, Lebowitz, Silverman, and Fernandez published a study on 68 children and their families that found that children with anxiety had similarly high levels of these mutations. Studying de novo mutations can help point the researchers to where they should be looking for genes associated with anxiety. “The end game is using the genes to steer us toward the right part of biology that we can then target to come up with better treatments,” Fernandez says. Building on those findings, the team is now studying more families to better understand how these de novo mutations, along with other genetic and environmental factors, shape pediatric anxiety disorders. They recently received a National Institutes of Health grant to enroll 750 new families over the next five years. Olfson is the principal investigator, with co-investigators Lebowitz, Fernandez, Silverman, and Shuangge Steven Ma, PhD, department chair and professor of biostatistics at Yale School of Public Health. Neurodevelopment, Risk Genes, and Mental Health Conditions - The Olfson Lab Joel Gelernter, MD, Foundations Fund Professor of Psychiatry, is interested in how different anxiety disorders differ genomically. “We are studying social phobia, panic disorder, and generalized anxiety disorder, working to understand why people differ in their risk to these specific anxiety disorders and evaluating various risk factors,” he says. Gelernter was recently involved in one of the largest studies to date of the genomics underlying anxiety disorder. The study included around 122,000 people with anxiety disorders and around 730,000 without. It found that some genetic differences associated with anxiety were linked to signaling that helps reduce overactivity in the nervous system. Many anxiety medications available today work by targeting this process. “It’s nice when the biology that you get out of a large genome-wide study ratifies things that we already know because that can help increase confidence in further findings from the study,” Gelernter says. Uncovering the neurobiology of psychiatric disorders John Krystal, MD, Robert L. McNeil, Jr. Professor of Translational Research and chair of the Department of Psychiatry, is interested in the neurobiology of psychiatric disorders, including post-traumatic stress disorder (PTSD), of which anxiety is a major symptom. In the late 1980s, Krystal’s team discovered that the drug yohimbine activated symptoms in patients with PTSD. “This was the first time we could link a specific biological mechanism to the symptoms of PTSD,” Krystal says. At the time, he adds, this finding was highly controversial. “A lot of people felt that PTSD was a purely psychological syndrome that didn’t have an underlying biology.” Since then, Krystal has dived deep into understanding the neurobiology of PTSD to learn how to better treat it. His team is evaluating the use of ketamine and psychedelics. These would be among the first treatments to be developed specifically for PTSD. They may also be applicable for other disorders including anxiety disorders, Krystal adds. An important gap in PTSD treatment is the absence of biological tests that inform how to best help patients manage their PTSD symptoms. A doctor doesn’t diagnose cancer based on how they feel. Rather, they use tests of the biology of the cancer to determine the best course of treatment. “And we can’t do that in any psychiatric disorder other than Alzheimer’s disease,” Krystal says. “But now we are building a foundation for this approach to the treatment of anxiety disorders for the first time.” Source: Yale School of Medicine
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