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Rockstar Explains How It Actually Makes A Game Like GTA 6
Working on one chunk at a time, for years and years and years, apparently
AZ-ALBERTSONS
Returning for her third year, actress, director and mom Haylie Duff will host a special cooking demo from 1:15 p.m. to 2 p.m.
Health care aide charged in assault of disabled resident at Halfmoon facility
A Schenectady woman working as a health care aide has been charged after State Police said a disabled resident was assaulted at a Halfmoon care facility.
Capitals’ Alex Ovechkin suddenly announces retirement plans
The 41-year-old forward has the end in sight.
Entertainment, work, study: 6 reasons the Dell XPS 13 is an everyday laptop worth looking at
The XPS 13 is a smart choice of notebook to cover all your daily needs
Juventus Following Dutch Duo Ahead of Next Summer
Two high-ranking Juventus officials attended the recent Nations League game between Germany and the Netherlands to keep tabs on Brian Brobbey and Virgil van Dijk. The pair is on their radar ahead of n...
Kings Symphony Orchestra to perform Fall Classics Concert
The Fall Classics Concert to be held on Sunday, Oct. 11, 2026, at
Italy’s Meloni follows pop stars in seeking to trademark her voice to combat AI deepfakes
Italian Premier Giorgia Meloni has applied to trademark her voice with the European Union intellectual property office in a bid to bolster protections against AI-generated deepfakes | KNSS Radio
How will humans of the future be augmented? Six striking ideas from science fiction
From expanded vision to immortal bodies, these screen depictions have all stretched our understanding of what technology could do to humans.
USA TODAY Sports Super 15 East region football rankings, Week 8
Here are the latest USA TODAY Sports East Region rankings following a wild week of high school football action.
Michael Duff set to be given the Bradford job
Bradford City are expected to name Michael Duff as the new manager according to reports.The Bantams have been looking for a new boss after Graham Alexander left the club to join Championship side Pre...
Zelda and Banjo Recompiled Devs Go To War With AI Vibe-Coded 'Slopcomps'
AI-assisted projects provoking stark criticism
Offensive Line Looks Offensive: Spartans Rank Last in Sacks Allowed
From personnel shifts to coaching failures, a crumbling front wall has left the Spartans reeling as record-breaking sack numbers threaten to derail the Pat Fitzgerald era.
Seedy K’s Pigskin Palaver: House of Cards & Much Mo’
Ah yes, October; the pigskin campaign is morphing more fully developed. And, fully enveloping. This week, there’s a football game on every single night. Not just the more traditional Thursday, Friday, Saturday, Sunday, Monday. Because Draft Kings and Fan Duel and The World Wide Leader need content, we get Southern Miss and Troy on Tuesday, […]
Permits issued for $22 million Perkins Road elementary school, new Southern Classic Chicken location
Here is a list of commercial and residential building permits issued by East Baton Rouge Parish Government from Sept. 28-Oct. 2.
Should Aging Be Called a Disease? Scientists Are Rethinking What It Means to Grow Older
What if the next big target in medicine is getting older itself? Researchers are taking that possibility seriously, with new tools, new clinics, and growing FDA attention. Instead of waiting for diabe...
What we learned from Wales' Nations League window
On the back of a demanding four-game international window, BBC Sport Wales assesses the key talking points from Wales' Nations League A campaign so far.
Team Kemistry: are the Tories making a comeback?
Conservative leader’s favourability rating surges but analysts say it’s ‘too early to talk about a Kemi-naissance’
Stephen King and Peter Straub’s Other Worlds Than These Will Break Your Heart
‘The Talisman’ finale is an emotional adventure story, resurrecting old friends, forgotten memories, and vanished worlds.
Windows malware uses Grok AI to help stay hidden, researchers say
x47.c Windows malware uses xAI's Grok to maintain persistence on infected PCs while stealing passwords, browser cookies and API keys from victims.
First Glance: Missouri Tigers
Aggies seeking a statement win to get the season back on track
Jeffries says House Democrats aiming to repeat 2018 sweep by flipping Trump districts
The Democratic Party is working to expand the map by going on offense in Republican-held districts, while President Donald Trump hits the trail in a red-state sprint to boost voter enthusiasm and shore up support from his base.
NFL looking into an official cursing at Cardinals tight end Trey McBride
Line judge Jeff Seeman was caught on camera cursing at McBride, which drew the ire of union leader JC Tretter
Apple Watch Prime Day Deals Arrive With New All-Time Low Prices for Series 12 and Ultra 4
Big Apple Watch discounts have started arriving ahead of Prime Big Deal Days, including new low prices on Apple Watch Series 12 and Apple Watch Ultra 4. These deals join some Apple Watch SE 3 discounts that we began tracking over the weekend, alongside other major early Prime Big Deal Days markdowns. Note: MacRumors is an affiliate partner with Amazon. When you click a link and make a purchase, we may receive a small payment, which helps us keep the site running.
Scientists Reveal The Optimal Amount of Sleep For Lower Dementia Risk
A huge analysis uncovered the sweet spot.
Why the creative brain feeds on movement
Movement and creativity go hand in hand. Scientists are working to discover why
Bluevine and Coverdash Partner to Bring Embedded Business Insurance to Small Businesses
/PRNewswire/ -- Bluevine, the largest small business banking platform in the US* and Coverdash, a leading embedded business insurance provider powering...
'Sabores of South Philly' offers personal look inside Latino-owned businesses of AEM
'Sabores of South Philly' is a marketing campaign launched this year by the Association of Mexican Business Owners, or AEM. The networking organization has over 70 members who are all entrepreneurs of Latino descent who own businesses throughout the city.
The Science Behind Female-Specific Firefighting PPE
Camilla Callesen, chief designer at VIKING Fire & Rescue, and retired firefighter Kendall Taylor discuss the research, engineering, and field testing behind the VIKING VALKYRIE.
From 4-H Member to Healthcare Leader: A Conversation with Davina Ferrero King
"My 4-H experience helped establish UConn in my mind as a place where I could continue growing academically, professionally, and personally."
DraftKings Rallies 5% as BoA Upgrades to Buy With $27 Price Target; Flutter Entertainment Ticks Up
A Wall Street firm that spent the past year avoiding DraftKings (NASDAQ:DKNG | DKNG Price Prediction) over prediction-market risk has lifted its view. DraftKings stock is up 5% to $19.46 in morning trading after Bank of America (NYSE:BAC) upgraded the shares to Buy from Neutral. Also, shares of Flutter Entertainment (NYSE:FLUT) are up 1%, a […]
DCCC Jumps Into PA-01 Contest With Coordinated TV Ad For Harvie
How important is the 1st Congressional District race between Rep. Brian Fitzpatrick and Bucks County commissioner Bob Harvie to Democrats? For the first time in six years, the Democratic Congressional Campaign Committee (DCCC) is making an investment in PA-01 with a coordinated TV ad for the Harvie campaign. Entitled "A…
Tracking health misinformation helps pediatricians provide targeted patient education
Pediatric clinicians can learn useful information by tracking the health misinformation that their patients encounter, according to research presented during the American Academy of Pediatrics 2026 National Conference & Exhibition Oct. 2-6, 2026, at the San Diego Convention Center.
Why more tools are making independent agents less productive
Having more technology than ever, independent agents are spending more time on administration, not less. The industry selling them those tools carries more responsibility for that than it typically admits
PEN America: Nearly 12,000 school book bans in a year, a record high
A new study from PEN America reveals that there were nearly 12,000 book bans in public schools over the past year, the highest since tracking began five years ago | WBBM Newsradio 780 AM & 105.9 FM
PEN America: Nearly 12,000 school book bans in a year, a record high
A new study from PEN America reveals that there were nearly 12,000 book bans in public schools over the past year, the highest since tracking began five years ago | Talk 1370
PEN America: Nearly 12,000 school book bans in a year, a record high
A new study from PEN America reveals that there were nearly 12,000 book bans in public schools over the past year, the highest since tracking began five years ago | KNSS Radio
PEN America: Nearly 12,000 school book bans in a year, a record high
A new study from PEN America reveals that there were nearly 12,000 book bans in public schools over the past year, the highest since tracking began five years ago | Talk Radio 1210 WPHT
PEN America: Nearly 12,000 school book bans in a year, a record high
A new study from PEN America reveals that there were nearly 12,000 book bans in public schools over the past year, the highest since tracking began five years ago | 1010 WINS
PEN America: Nearly 12,000 school book bans in a year, a record high
A new study from PEN America reveals that there were nearly 12,000 book bans in public schools over the past year, the highest since tracking began five years ago.
PSA: Kingdom Hearts Collection Will Collectively Take Up Over 130GB On Switch 2
Still better than the cloud
Kingdom Hearts Collection Will Collectively Take Up Over 130GB On Switch 2
Still better than the cloud
Windber institute's data tracking system used by scientists far and wide
Developed by a member of the Chan Soon-Shiong Institute of Molecular Medicine at Windber, a system for using data to solve real-world problems caused by cancer is making a mark
Duke Recruiting: Crystal Balls For A Five-Star Target
Are things looking good for Asa Montgomery to Duke?
Apple Health Age test: What to expect
Bridget Carey puts Apple's new Health Age test to the test, from squats to walking, and finds out how she measures up.
Democrats release midterms ad featuring family of Epstein victim Virginia Giuffre
The campaign arm working to elect House Democrats released a political advertisement on Monday featuring the family of Virginia Giuffre, who was the first victim of Jeffrey Epstein to go public with allegations of abuse.
Involuntary treatment remains sticking point in new mental health legislation
Signing of SB 989 makes it easier for first responders to initiate CARE Court petitions.
Building something with your hands — and a career
MakerSpace NYC is one of at least 2,000 community workshops across the country.
Science Highlights Six Overlooked Pioneers Who Missed the Nobel Prize in Medicine
The international journal Science has spotlighted six groundbreaking achievements in the life sciences that never received Nobel Prize recognition.…
Galaxy S27 Ultra colors leak, and Samsung could be breaking up with purple
Leaked Galaxy S27 Ultra colors suggest Samsung is retiring Deep Purple for another, surprising shade of color.
Spooky season watchlist
In October 2024, I drove into Gambrill State Park after dusk and joined others carrying blankets and lawn chairs — flashlight streams lighting the road and parking lot — as
What Holding Eye Contact While Someone Speaks Really Reveals About Your Psychology, According to Science
You are mid-conversation with a friend, nodding along, and suddenly you wonder: am I looking at them too much? Or not enough? Most of us treat eye contact like an automatic reflex – something we either do or don’t, without thinking twice. But researchers say the way you hold someone’s gaze while they speak is...
Android Auto could soon stop working on millions of phones
Android Auto appears to be preparing another compatibility cutoff, with Android 10 users now being warned that support will end soon.
Mac Users Reclaim Storage With New Apple Intelligence Removal Tool
A new open-source tool is making waves in the Mac community by helping users reclaim valuable storage space taken up by Apple's AI models. Called "RemoveMacAI," the tool disables Apple Intelligence on macOS 27, removes its downloaded models, and prevents them from being downloaded again. In macOS 27, Apple removed the toggle to disable Apple Intelligence wholesale, and simply disabling individual features doesn't remove the models from your Mac's drive.
Kingdom Hearts I-III for Switch 2 should've been a slam dunk, but some games need more work
The inconsistent port quality and issues hold some of these KH games back on Switch 2. Square Enix should've done more.
Integral Ad Science to Provide Brand Safety and Suitability Measurement in ChatGPT Ads
NEW YORK, October 05, 2026--As artificial intelligence rapidly reshapes digital advertising, marketers face a critical new challenge: ensuring brand safety and suitability within dynamic, generative AI-native environments. Without independent verification, advertising in conversational channels risks creating a blind spot for enterprise brands seeking reliable media quality standards.
Providence Opens New Rural Health Clinic in Polson
Just over a year after breaking ground on a rural health clinic in Polson, community members, donors and hospital staff gathered Sept. 30 in front of the new building just behind Providence St. Joseph Medical Center. “Over the years we’ve heard about this need over and over again,” Chief Executive for Providence Montana Krissy Petersen […]
Lions vs. Cardinals odds: Opening lines for Week 5 matchup
Checking in on the opening betting odds for the Week 5 matchup between the Detroit Lions and the Arizona Cardinals.
Nobel medicine prize goes to 3 scientists for research into brain activity
The Nobel Prize in medicine was awarded Monday to three scientists working on the mechanisms the brain uses to switch on, or off, the activity of individual nerve cells.
'Clearly not working': Sam Altman hits AI industry over political spending
In a wide-ranging interview, the OpenAI CEO criticized the flood of AI dollars swamping the midterm elections and suggested a new liability framework is needed for autonomous hacks.
‘Clearly not working’: Sam Altman hits AI industry over political spending
In a wide-ranging interview, the OpenAI CEO criticized the flood of AI dollars swamping the midterm elections and suggested a new liability framework is needed for autonomous hacks.
$350 million Memorial Health project to bring road and parking changes
A $350 million Memorial Health project will add a 90-bed tower, cafeteria, loading dock and parking garage.
Jobs in health care. Jobs for women. The US labour market is segmenting. Chernobyl’s radiation and Lenin’s love of literature.
Thank you for opening your Chartbook email. Elmer Bischoff, Two Figures at the Seashore, 1957 The only really dynamic job-creator in the US economy is health care: The largest crunch has come in Federal government, which has shed 2.7 m jobs. Source: tchouvkov on Twitter Tech is struggling. [ Joey Politano 🏳️🌈@JosephPolitano The US tech sector continues bleeding jobs in official data released today—overall, employment decreased by 17k last month and is down 69k over the last year That's nearly as bad as the worst of the 2024 tech-cession, and much worse than the 2022 boom or even pre-2020 norms 12:42 PM · Oct 2, 2026 · 15.2K Views 15 Replies · 47 Reposts · 390 Likes ](https://x.com/JosephPolitano/status/2106001807847940232?s=20) The new jobs are all for women. [ Justin Wolfers@JustinWolfers I'm not sure who saw this coming, but so far nearly all the jobs created during the second Trump administration have gone to women. 1:09 PM · Oct 2, 2026 · 33K Views 70 Replies · 146 Reposts · 644 Likes ](https://x.com/JustinWolfers/status/2106008723533533601?s=20) Meanwhile, real wages are being eaten up by modest over-target inflation. [ Heather Long@byHeatherLong The financial pain is real: Wage growth fell to 3% (y/y) in September. That's the lowest in 5 years. Wage growth: 3% Inflation: ~3.4% Inflation has eaten up all wage gains for the average worker since April. Many people are having to make hard choices about what to buy and what … 1:24 PM · Oct 2, 2026 · 37K Views 24 Replies · 275 Reposts · 533 Likes ](https://x.com/byHeatherLong/status/2106012367712620728?s=20) HEY READERS, THANK YOU for opening the Chartbook email. I hope it brightens your day. I enjoy putting out the newsletter, but tbh, what keeps this flow going is the generosity of those readers who clicked the subscription button. If you are persuaded to click, please consider the annual subscription of $60. It is both better value for you and a much better deal for me, as it involves only one credit card charge. Why feed the payments companies if we don’t have to. Subscribe Elmer Bischoff, Bathers, 1960 Americans are disillusioned with higher ed. For contributing subscribers only. Subscribe Where the Chernobyl radiation went. h/t Simon Kuestenmacher aka simongerman600 How Lenin’s love of literature shaped the Russian Revolution - Tariq Ali This, then, was the intellectual atmosphere in which Lenin came of age. His father, a highly cultured conservative, was the chief inspector of schools in his region and much respected as an educationalist. At home, Shakespeare, Goethe and Pushkin, among others, were read aloud on Sunday afternoons. It was impossible for the Ulyanov family – “Lenin” was a pseudonym adopted to outwit the tsarist secret police – to escape high culture. At high school, Lenin fell in love with Latin. His headteacher had high hopes that he might become a philologist and Latin scholar. History willed otherwise, but Lenin’s passion for Latin, and taste for the classics, never left him. He read Virgil, Ovid, Horace and Juvenal in the original, as well as Roman senatorial orations. He devoured Goethe during his two decades in exile, reading and rereading Faust many times. Lenin put his knowledge of the classics to good use in the time leading up to the October revolution of 1917. In April of that year, he broke with Russian social-democratic orthodoxy and, in a set of radical theses, called for a socialist revolution in Russia. A number of his own close comrades denounced him. In a sharp riposte, Lenin quoted Mephistopheles from Goethe’s masterwork: “Theory, my friend, is grey, but green is the eternal tree of life.” Source: The Guardian Elmer Bischoff, The River, 1953 If you’ve scrolled this far, you know you want to click: Subscribe
Yale School of Medicine On the Science of Childhood Anxiety, Say, Anxiety Disorders Are the Most Common Mental Health Challenges In Youth
Credit: Matt Bradbury October 5, 2026 - By Isabella Backman - Anxiety disorders are the most common mental health challenges in youth. Left untreated, they can disrupt the lives of both children and their families. The good news is that with intervention, most children will overcome these conditions. Across Yale School of Medicine, scientists are working to understand anxiety at every level, from common anxious behaviors to molecular biomarkers in the brain. They are using their findings to develop and disseminate new evidence-based treatments for childhood anxiety. Today, the go-to treatment for childhood anxiety disorders is cognitive behavioral therapy (CBT). This is a form of psychotherapy that teaches children skills for confronting anxious thoughts and helps them practice managing situations that cause anxiety. While it is the gold-standard treatment backed by considerable scientific evidence, up to 50% of children will not see sufficient benefit from CBT alone. Wendy Silverman, PhD, Alfred A. Messer Professor in the Child Study Center, co-directs the Anxiety and Mood Disorders Program alongside Eli Lebowitz, PhD, associate professor in the Child Study Center. One of their main interests is learning how to improve outcomes beyond CBT. “We’re developing cutting-edge, research-based knowledge that can reduce the suffering that anxiety causes children and their families,” says Silverman. Changing parent behavior YSM experts are investigating how to improve CBT outcomes for children by involving the parents. Silverman’s research has uncovered two main components of parent intervention that improve childhood anxiety: not enabling children to completely avoid the things that make them anxious and taking steps to enhance their autonomy. Parents may unintentionally reinforce their child’s anxiety by allowing them to avoid what makes them anxious. They also may unintentionally limit the children’s sense of autonomy by being overly intrusive. “One of the things that we take pride in is that we’ve focused on trying to understand what parents need to do, and to test our ideas and see if changing the parents’ behaviors is enhancing the effects of CBT,” Silverman says. “Our findings thus far suggest that they do." As much as CBT can be helpful, it can also be challenging to get one’s child to do the necessary steps for CBT to work. This is one important reason why Lebowitz created a novel intervention program for parents named Supportive Parenting for Anxious Childhood Emotions (SPACE). Existing intervention programs often teach parents to act as therapists for their child, such as training them on how to practice breathing exercises. “It makes sense, but this doesn’t work very well in practice,” says Lebowitz. “And part of the reason, I think, is that it’s not easy to get your kid to do things, especially if they’re not excited about doing it.” SPACE is unique because it focuses entirely on parent involvement and changing parental behavior—children are not involved in the sessions. For example, parents learn how to use supportive messages that convey confidence that their child can tolerate and manage distress. “It might sound like a parent saying to a child, ‘I get that this is really hard for you, but I know that you can handle it,’” Lebowitz says. The program also works with parents to identify the ways in which they are accommodating anxious behaviors. “We’ll pick one thing that parents are doing that is an accommodation and help them make a detailed plan for how they’re going to change that,” Lebowitz explains. Treating Anxiety in Children and Adolescents Much of the existing research on SPACE has focused on parents of children under age 14. Ongoing studies are now exploring its use with parents of older teens. “Both anxiety and accommodation can interfere with normative developmental shifts during the teen years, including increased autonomy and individuation from parents,” says Rebecca Etkin, PhD, associate research scientist in the Child Study Center. “In this sense, SPACE may be particularly well-suited for anxious teens and their parents. We want to see whether it is effective during this distinct developmental window.” Unfortunately, many families in need of CBT face barriers, including limited availability of services and geographic constraints. One way to improve access is digital interventions. Silverman and her team are developing an evidence-based digitized intervention program for parents that they can access directly from their computer or smart phone. “The work we’re doing will be one of the very few parent interventions that is digitized and importantly tested for effectiveness,” she says. Creating interventions for anxiety-related challenges Silverman and Lebowitz recently received a generous gift to develop and test other interventions that help parents reduce other child anxiety-related behavioral and emotional difficulties, such as restrictive eating and unexplained somatic symptoms. One of these projects in particular focuses on understanding the risks of social media and its potential benefits, including offering a sense of connection. “A lot of research has focused on the idea that social media is harmful and the less of it the better,” says Lebowitz. “But we actually see is that this is not quite right—there are negatives, but there are also positives. So, we’re trying to get a little bit more nuanced of a picture.” The team is working with teens with social anxiety and their parents over an extended period to better understand their social media habits and how their anxiety levels affect engagement with different platforms. The teens will answer questions sent to an app on their phones about mood and social media usage in an effort to capture emotional responses as they unfold. “We hope to develop interventions that can help make the best of social media while protecting against the more problematic effects,” Lebowitz says. The brain’s role in anxiety Researchers are also testing therapies to address anxiety at the neurological and molecular levels. In collaboration with Dylan Gee, PhD, professor of psychology in Yale's Faculty of Arts and Sciences, and Hilary Blumberg, MD, John and Hope Furth Professor of Psychiatric Neuroscience at Yale School of Medicine, Lebowitz and Silverman are using brain imaging to identify changes in a child’s brain before and after parents enroll in SPACE. In one study, children viewed anxiety-inducing images while undergoing magnetic resonance imaging (MRI); the researchers conducted scans with and without the children’s parents nearby. Before SPACE, children’s brains were better able to activate the regulatory circuitry needed to turn off an anxious response when their parents were nearby. But after SPACE, children could activate this circuitry even without the parent around. “As parents work on gradually reducing some of their accommodations, you can see a child get better at regulating their own fear system in the brain,” Lebowitz says. “It’s remarkable.” Research into the molecular underpinnings of anxiety can also inform new childhood anxiety treatments. In a recent study, Lebowitz, Silverman, and Flora Vaccarino, MD, Harris Professor in the Child Study Center, discovered that a protein known as fibroblast growth factor 2 (FGF2) could be protective from the toxic effects of stress. FGF2 levels in children and their parents were linked to the children’s risk of developing anxiety and depression, the study showed. The findings could help explain why some children who are exposed to early life trauma such as poverty or abuse are more prone to developing mental health disorders. And FGF2 could be a target for treatment. “This is very novel because it starts to give a clue to what is the molecular chain that connects those lived experiences to the actual psychological outcomes,” Lebowitz says. New ways to study and treat childhood anxiety Michael Crowley, PhD, associate professor in the Child Study Center, collaborates with Silverman and Lebowitz to study the role that attention plays in development and maintenance of childhood anxiety. There is a large body of research that shows that anxious children, like anxious adults, are prone to focus on threatening stimuli such as angry faces compared with neutral faces. This has led to innovative interventions that involve attention retraining. The idea is that if experts train children to look away from threatening stimuli, it may reduce their anxiety—especially children with social anxiety who are most prone to attend to threats. The researchers have just completed a clinical trial for attention retraining with 10- to 14-year-olds with social anxiety disorders and are currently analyzing the findings. Besides this innovative attention retraining research, as Crowly notes, “I like to design tasks that are engaging to kids,” Crowley says. “My goal is to assess something without the kids knowing what we are assessing.” With this goal in mind, Crowley has created a virtual game, named Boom, to study threat processing in children with anxiety disorders. The game is similar to that of hot potato—the child and three digital players take turns virtually passing a ball to each other’s gloves. At some point, the ball turns into a bomb, and as the bomb lands in each player’s glove, the outline of the glove turns yellow. The goal is to avoid having the bomb go off in your glove. What isn’t obvious is that the game is designed to measure different types of threatening stimuli, both ambiguous and direct. In the game, the direct threat occurs as the bomb is traveling towards your glove. The ambiguous threat is the yellow outlined glove as it is unknown where the bomb will travel next. While children play the game, Crowley’s team measures their brain activity using electroencephalography (EEG). The researchers have discovered that in kids with anxiety, the brain reacts more strongly to ambiguous threats than it does in their peers, but less strongly to direct threats. They believe that the initial abnormally large brain response to not knowing where the bomb is going impairs the brain's ability to properly respond when the threat is actually traveling the child’s way. “The brains of children with anxiety are unable to differentiate between threats you need to do something about and those that are not your problem.” Michael Crowley, PhD, develops innovative games for studying anxiety in children and adolescents.Credit: Matt Bradbury Based on these insights, Crowley hopes to study whether interventions like attention training could restore appropriate threat processing. Crowley’s team is also working on a test called the Balloon Risk Avoidance Task, which evaluates risk-taking and avoidance behaviors. It features a digital balloon that is full of air and about to burst. Kids have six seconds to let air out of the balloon. The more air they let out, the less risk they face that the balloon will pop. But at the same time, the balloon becomes less valuable as it deflates. “The more air you keep in the balloon, the more points you get,” Crowley explains. So far, the researchers have found that when the balloons pop unexpectedly, teens with social anxiety show distinct brain responses. Studying these responses can help psychologists understand the underlying pathways driving the various manifestations of anxiety. The genetics of anxiety When Thomas Fernandez, MD, associate professor in the Child Study Center and of psychiatry, was still in training, there was a lot of excitement about understanding the genetics associated with autism spectrum disorder. Since then, scientists have identified around 250 genes associated with autism. The genetic contribution to anxiety disorders, on the other hand, has historically received less attention. Anxiety is less heritable than autism, but the genetic contribution for anxiety disorders that emerge in childhood may be higher than for anxiety disorders overall. While scientists estimate the heritability of anxiety disorders in general to be around 30% to 50%, some studies suggest higher heritability for certain childhood-onset anxiety presentations. “I saw firsthand how researchers in the field went about finding vulnerability genes for autism,” Fernandez says. “So, we’re using a very similar playbook for childhood anxiety.” “I saw firsthand how researchers in the field went about finding vulnerability genes for autism. So, we’re using a very similar playbook for childhood anxiety.” Thomas Fernandez, MD Associate Professor In the Child Study Center and in Psychiatry Now, Fernandez and Emily Olfson, MD, PhD, assistant professor in the Child Study Center, are studying children and their parents to identify genetic changes that are present in the child but not the parents, known as “de novo mutations.” “All of us have some de novo mutations—maybe about 50 to 100 sprinkled throughout the genome,” Olfson says. “But when they occur within the coding regions of genes, they can be really disruptive.” Previous research shows that people with autism have higher rates of damaging de novo mutations than the general population. In 2022, Olfson, Lebowitz, Silverman, and Fernandez published a study on 68 children and their families that found that children with anxiety had similarly high levels of these mutations. Studying de novo mutations can help point the researchers to where they should be looking for genes associated with anxiety. “The end game is using the genes to steer us toward the right part of biology that we can then target to come up with better treatments,” Fernandez says. Building on those findings, the team is now studying more families to better understand how these de novo mutations, along with other genetic and environmental factors, shape pediatric anxiety disorders. They recently received a National Institutes of Health grant to enroll 750 new families over the next five years. Olfson is the principal investigator, with co-investigators Lebowitz, Fernandez, Silverman, and Shuangge Steven Ma, PhD, department chair and professor of biostatistics at Yale School of Public Health. Neurodevelopment, Risk Genes, and Mental Health Conditions - The Olfson Lab Joel Gelernter, MD, Foundations Fund Professor of Psychiatry, is interested in how different anxiety disorders differ genomically. “We are studying social phobia, panic disorder, and generalized anxiety disorder, working to understand why people differ in their risk to these specific anxiety disorders and evaluating various risk factors,” he says. Gelernter was recently involved in one of the largest studies to date of the genomics underlying anxiety disorder. The study included around 122,000 people with anxiety disorders and around 730,000 without. It found that some genetic differences associated with anxiety were linked to signaling that helps reduce overactivity in the nervous system. Many anxiety medications available today work by targeting this process. “It’s nice when the biology that you get out of a large genome-wide study ratifies things that we already know because that can help increase confidence in further findings from the study,” Gelernter says. Uncovering the neurobiology of psychiatric disorders John Krystal, MD, Robert L. McNeil, Jr. Professor of Translational Research and chair of the Department of Psychiatry, is interested in the neurobiology of psychiatric disorders, including post-traumatic stress disorder (PTSD), of which anxiety is a major symptom. In the late 1980s, Krystal’s team discovered that the drug yohimbine activated symptoms in patients with PTSD. “This was the first time we could link a specific biological mechanism to the symptoms of PTSD,” Krystal says. At the time, he adds, this finding was highly controversial. “A lot of people felt that PTSD was a purely psychological syndrome that didn’t have an underlying biology.” Since then, Krystal has dived deep into understanding the neurobiology of PTSD to learn how to better treat it. His team is evaluating the use of ketamine and psychedelics. These would be among the first treatments to be developed specifically for PTSD. They may also be applicable for other disorders including anxiety disorders, Krystal adds. An important gap in PTSD treatment is the absence of biological tests that inform how to best help patients manage their PTSD symptoms. A doctor doesn’t diagnose cancer based on how they feel. Rather, they use tests of the biology of the cancer to determine the best course of treatment. “And we can’t do that in any psychiatric disorder other than Alzheimer’s disease,” Krystal says. “But now we are building a foundation for this approach to the treatment of anxiety disorders for the first time.” Source: Yale School of Medicine
AtkinsRéalis on human-centric themed entertainment
AtkinsRéalis reveals how engineering, storytelling and strategy combine to create meaningful, lasting experiences in a fast-evolving market
Dan Campbell: I'm not talking about firing Kelvin Sheppard
The Lions defense was unimpressive in the first three weeks of the 2026 season and things didn't get any better in Sunday night's loss to the Panthers.
CMS Mulls Cuts to Business Services Staff
CMS follows other law firms, such as Baker McKenzie and Clifford Chance, in seeking out savings in its back-office functions.
Renée Slegers has full backing from Arsenal despite slow start
Arsenal are not looking to dismiss manager Renée Slegers despite a slow start to the 2026/27 season.The Gunners have won just one of their opening five matches in the WSL which sees them ninth in the...
King Drive Business Improvement District budget expands for 2027
The Historic King Drive Business Improvement District's 2027 operating plan, which includes a budget increase, will head to the common council for approval.
Democratic socialists scored big primary wins. But that’s not the whole story.
DSA-backed candidates, sharp critics of Israel, made historic gains. But a closer look makes clear they’re not taking over the Democratic Party – so far.
Nobel medicine prize goes to 3 scientists for research into brain activity
The Nobel Prize in medicine was awarded Monday to three scientists working on the mechanisms the brain uses to switch on, or off, the activity of individual nerve cells.
Northwest Arkansas growing pains, national concerns top issues at Springdale political gathering
Rain and overcast skies didn’t dampen the mood at the annual Chickin, Peelin’ & Politickin’ event Thursday at Springdale’s Shiloh Square as residents, business owners and elected officials networked over plates of fried chicken and shrimp.
In rural Wisconsin, politics is still about meeting voters. Online, it’s getting weird.
Rebecca Cooke is taking her campaign directly to rural Wisconsin communities, all while an AI-fueled online fight with her Republican opponent adds a distinctly 2026 twist to the race.
Michigan's largest banks after the Fifth Third-Comerica deal
Consolidation continues to shift the list of the largest players in Michigan's banking industry.
49ers Handed Intriguing Take on Vita Vea After Defeating Broncos
The San Francisco 49ers sit at 4-0 through four weeks, and the trade deadline is on Nov. 10, but if the team keeps playing like this, it’s clear they’ll be buyers looking to improve.Wide receiver and the defensive line are two areas of concern for the Niners given the injuries and lack of depth. On […] The post 49ers Handed Intriguing Take on Vita Vea After Defeating Broncos appeared first on HEAVY.
Nobel Prize in medicine awarded to three scientists for their work ‘concerning light-gated ion channels and optogenetics’
The 2026 Nobel Prize for physiology or medicine has been awarded to three scientists – Karl Deisseroth, Peter Hegemann and Georg Nagel – for “their discoveries concerning light-gated ion channels and optogenetics.”
We're witnessing a critical moment for Amazon Kindles
Amazon is finally listening to Kindle fans, bringing back physical buttons and adding fresh accessories. But, there's a catch.
Rethinking discovery: how powerful screening tools are redefining the search for new medicines
In medicine discovery, identifying the right biological target has always been a critical and complex step. Today, the rise of powerful screening tools is fundamentally reshaping this process, creating a step-change in how we move from scientific hypotheses to transformative medicines. Advances in high-throughput screening, genomics and AI-driven analytics are enabling scientists to interrogate disease biology at unprecedented scale, bringing forward opportunities that were previously beyond reach.
Democrats Expect Record Number of Women in Party in House After Midterm Elections
Democrats are increasingly confident they will have a record number of women serving in the House next year, after backing women in competitive districts they are now positioned to win.
How affordability will impact the midterm elections in swing states
It's almost election time in America, and voters in swing states are looking at their wallets — and gas prices — at the ballot box.
BagelUp Growth Lab Returns as Business Incubator for Emerging Bagel Entrepreneurs, Launching a Year-Round Partner Program
Great bagels may start with flour, water, yeast and skill, but building a successful bagel business takes much more. On Saturday, November 14th, 2026, BagelUp (which produces New York BagelFest) will present the second annual BagelUp Growth Lab, a business incubator designed to help promising bagel entrepreneurs gain the knowledge, connections and industry resources needed to turn their bagel concepts into sustainable businesses. Taking place at Loft 39 the day before New York BagelFest at Citi
This Kenner 'beach' thrives on volleyball, cold beer, decades of camaraderie: 'We're still here'
If it weren’t for the glowing lights of Planet Fitness and Treasure Chest Casino at the strip mall a few feet away, you could almost forget this beach is in the middle of a parking lot in Kenner. Here’s why locals drive from New Orleans and beyond each week to hang out, play ball or drink a few cold ones.
Digital Science Appoints Charlesworth as Strategic Sales Partner of Altmetric and Dimensions in China's Scholarly Publishing Sector
London, United Kingdom--(Newsfile Corp. - October 5, 2026) - Digital Science has appointed Charlesworth as its strategic sales partner of Altmetric and Dimensions in China's scholarly publishing sector. This collaboration aims to support the growing demand for research data and information across this rapidly developing market.China's local publishing industry has grown significantly in scale and maturity, with journal publishers actively strengthening their international position, investing in.
CT offers $1,200 health insurance subsidy to child care workers
About 18% of the 31,000 working early childhood educators in Connecticut are uninsured, according to a 2026 study.
CT offers $1,200 health insurance subsidy to child care workers
About 18% of the 31,000 working early childhood educators in Connecticut are uninsured, according to a 2026 study.
Doctors Should Keep an Eye on Your Mix of Medication. If They Don’t, You Should.
There’s a term for reducing unnecessary or harmful drugs: “deprescribing.” Especially as patients age, experts say, it’s important to regularly review the medications they’re taking.
Voters are increasingly using AI chatbots to fact-check and compare candidates
Voters are already voting in the midterms. This year, some voters are trying something new to get ready for the election: asking AI to help research their ballot and even decide who to vote for.
Voters are increasingly using AI chatbots to fact-check and compare candidates
Voters are already voting in the midterms. This year, some voters are trying something new to get ready for the election: asking AI to help research their ballot and even decide who to vote for.
Strawberries in February: The Cyclospora outbreak and the cost of convenience
The 2026 outbreak reveals strains on farmworkers, food inspections and disease tracking in a system where consumers demand fresh produce year-round.
LinkedIn pros have found a new key to getting opportunities: selfies
LinkedIn creators are increasingly seeing work selfies and casual videos build trust and grow audiences that lead to jobs and speaking opportunities.
Silicon Valley hottest funding source: the Bank of Best Friends
As big money deals in venture capital dry up, tech founders are asking mom, dad, and friends to open their wallets.
Can the Seminoles Men’s Basketball Take the Next Step?
After coming within one shot of being on the March Madness bubble last season, Florida State enters Year 2 under Luke Loucks, looking to take the next step and get to the Big Dance for the first time since 2021.
Driving Community Health: Bristol Myers Squibb, Emirates Thalassemia Society and Dubai Science Park Host the 6th 'Help Save a Life' Blood Donation Drive
For patients living with chronic blood disorders, access to safe and reliable blood supplies is fundamental to their care journey. Marking the sixth edition of an impactful partnership, Bristol Myers Squibb proudly collaborated with the Emirates Thalassemia Society and Dubai Science Park, the region's leading science focused hub and part of TECOM Group PJSC, hosted the 'Help Save a Life' blood donation drive, bringing together community members and healthcare professionals to provide vital suppo
Driving Community Health: Bristol Myers Squibb, Emirates Thalassemia Society and Dubai Science Park Host the 6th 'Help Save a Life' Blood Donation Drive
For patients living with chronic blood disorders, access to safe and reliable blood supplies is fundamental to their care journey. Marking the sixth edition of an impactful partnership, Bristol Myers Squibb proudly collaborated with the Emirates Thalassemia Society and Dubai Science Park, the region's leading science focused hub and part of TECOM Group PJSC, hosted the 'Help Save a Life' blood donation drive, bringing together community members and healthcare professionals to provide vital suppo
Driving Community Health: Bristol Myers Squibb, Emirates Thalassemia Society and Dubai Science Park Host the 6th 'Help Save a Life' Blood Donation Drive
/PRNewswire/ -- For patients living with chronic blood disorders, access to safe and reliable blood supplies is fundamental to their care journey. Marking the...
Driving Community Health: Bristol Myers Squibb, Emirates Thalassemia Society and Dubai Science Park Host the 6th 'Help Save a Life' Blood Donation Drive
/PRNewswire/ -- For patients living with chronic blood disorders, access to safe and reliable blood supplies is fundamental to their care journey. Marking the...
Spain services growth accelerates despite cost surge, PMI shows
Oct 5 (Reuters) - The expansion in Spain's service sector picked up pace in September as increased demand lifted activity despite a surge in operating expenses, a business survey showed