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Why iPad's Magic Keyboard Has A USB-C Port – And When To Use It
Apple's Magic Keyboard is a handy accessory for leveling up your iPad and it comes with a built-in USB-C port that can be used to charge your tablet.
‘Practice-changing’ interventional cardiology research grabs ACC.26 spotlight
The second day of the American College of Cardiology’s annual conference started with a series of highly anticipated interventional cardiology trials.
Report: Liverpool considering move to sign Serie A forward
Liverpool Transfer Latest: Francisco Conceição Emerges as Salah Contingency OptionLiverpool’s recruitment drive ahead of a crucial summer window continues to gather pace, with fresh developments p...
iOS 27 Rumored to Feature All-New Siri App With 'Extensions' Feature
In his Power On newsletter today, Bloomberg's Mark Gurman discussed Apple's upcoming AI plans in more detail. As he reported last week, this will apparently include a Siri app with a so-called "Extensions" feature across iOS 27, iPadOS 27, and macOS 27. With the Siri app, the report said that iPhone, iPad, and Mac users would be able to interact with Apple's assistant in both text and voice modes.
[*LIVE*] Purdue vs Arizona Live Free Streams On Sport'sTvｌ 29 March 2026
Purdue vs Arizona in a highly anticipated clash of the 2026.These rule changes are seen as part of Live NCAAM Men's Collage BasketBall ongoing efforts to evolve the game and maintain competitive integrity across formats.Pluto TV and All Men's Sports Network Forge Global Partnership to Launch a New FAST Channel and Media.
[*LIVE*] Iowa vs Illinois Live Free Streams On Sport'sTvｌ 29 March 2026
Iowa vs Illinois in a highly anticipated clash of the 2026.These rule changes are seen as part of Live NCAAM Men's Collage BasketBall ongoing efforts to evolve the game and maintain competitive integrity across formats.Pluto TV and All Men's Sports Network Forge Global Partnership to Launch a New FAST Channel and Media.
Phil Weiser wins top spot in Colorado’s Democratic gubernatorial primary at party’s state assembly
Attorney General Phil Weiser’s name will appear first on Colorado’s Democratic gubernatorial primary ballot after his overwhelming win Saturday at the party’s state assembly in Pueblo. Weiser joins U.S. Sen. Michael Bennet in the June 30 primary for the office held by term-limited Gov. Jared Polis. Bennet, who successfully petitioned onto the ballot, didn’t participate […]
4 Costco Tablet Accessories To Upgrade Your iPad Experience
Costco sells several accessories to upgrade your iPad, including the Apple Pencil Pro, Magic Keyboard, AirTag trackers, and Acer portable monitor.
Fox News Entertainment Newsletter: David Spade slams Newsom and Bass, Howie Mandel calls out Kelly Ripa
The Fox News Entertainment Newsletter brings you the latest Hollywood headlines, celebrity interviews and stories from Los Angeles and beyond.
Fox News Entertainment Newsletter: David Spade slams Newsom and Bass, Howie Mandel calls out Kelly Ripa
The Fox News Entertainment Newsletter brings you the latest Hollywood headlines, celebrity interviews and stories from Los Angeles and beyond.
These iPad apps will make you wish you had more free time
If you have an iPad and want to start using it to unleash and express your creativity, there are a number of apps that can help you do so.
Girls Forward program provides teen girls with safe space to play sports
Elli Lewis, the Girls Forward program manager, and Oana, a participant in the program, join NY1.
US lawmakers say they'll visit Taiwan before Trump's summit with China's Xi
A bipartisan group of senators has plans to visit Taiwan, Japan and South Korea
Photos: Saints, Pelicans, Entergy host STEM Fest 2026
The New Orleans Saints and New Orleans Pelicans teamed up with Entergy to host STEM Fest 2026 where students participated in various Science, Technology, Engineering, and Math activities at the New Orleans Saints practice Facilities on March 28, 2026.
5+ Things to Know About the Siri Chatbot Coming in iOS 27
We're less than three months away from our first look at Apple's smarter, redesigned version of Siri. iOS 27, iPadOS 27, and macOS 27 will focus on Siri updates, and rumors about what we can expect are picking up. There's a full chatbot version of Siri in the works, which will change the way that we use Apple's personal assistant. Siri will be more like Claude or ChatGPT, marking a major improvement in how Siri works and what it can do.
‘Families not Politics’ coalition launches to oppose Colorado ballot measures targeting transgender minors
Advocacy organizations in Colorado have launched a campaign opposing two November ballot measures that would regulate transgender minors’ participation in school sports and access to certain medical procedures, setting the stage for a statewide debate over youth policy and parental decision‑making. Dubbed “Families Not Politics,” the coalition was established to “defend the freedoms, privacy, and […]
Elon Musk Joins in Phone Call Between Donald Trump and Narendra Modi
Mr. Musk’s participation was notable because it is rare for a private citizen to be on a call between heads of state. It also suggests that Mr. Musk is back on better terms with the president.
Findings on Entrepreneurs’ Earnings and Key Lessons - Small Business & Entrepreneurship Council
by Raymond J. Keating – While many entrepreneurs go through some tough times – particularly as their businesses are being started and during the early years – on the income front, as a business develops and grows, the anticipation is that revenue and earnings will grow, and so will the income of the entrepreneurs that […]
NASA Names Scientists to Support Lunar South Pole Science
NASA has selected 10 participating scientists to help shape a science plan for astronauts to complete on the lunar surface under the Artemis program –
New dean of the College of Health Sciences announced
UK Provost Robert DiPaola has named Phillip Gribble dean of the College of Health Sciences, pending Board of Trustees approval.
Apple Says No iPhone in Lockdown Mode Has Ever Been Hacked
Apple says it has no record of a successful spyware attack against any device running Lockdown Mode, the opt-in security feature it introduced in 2022. "We are not aware of any successful mercenary spyware attacks against a Lockdown Mode-enabled Apple device," an Apple spokesperson told TechCrunch. Lockdown Mode is available on the iPhone, iPad, and Mac, and dramatically restricts certain system features that are commonly exploited by mercenary spyware.
Science in images: Argentina’s experience in the Wiki Science Competition
The Wiki Science Competition in Argentina In recent years, Argentina has participated in two editions of the Wiki Science Competition (WSC), the international scientific photography competition sta…
Apple Now Sending Critical Security Alerts to iPhones Running iOS 17 and Earlier
Apple has begun pushing Lock Screen notifications to iPhones and iPads running older versions of iOS and iPadOS, warning users of active web-based attacks. The alerts, which appear as a "Critical Software" notification from the Settings app, warn that Apple "is aware of attacks targeting out-of-date iOS software, including the version on your iPhone," and urge users to install a critical update to protect their device.
‘Today’: Savannah Guthrie Breaks Down ‘Hard’ Decision to Return to Show
Savannah will make her highly anticipated return to Studio 1A next month.
New Resident Evil Requiem patch adds highly-anticipated photo mode feature
The powers that be at Capcom have released an update for Resident Evil Requiem, which along with other fixes and such also adds photo mode.
How to share files from Galaxy phones to iPhones and MacBooks
Samsung introduced a major new feature to the Galaxy S26 series this week. Quick Share on these devices is now compatible with Apple’s AirDrop system, making it easier to share files wirelessly with iPads, iPhones, and Macs. So, how do you use it? Let’s take a look. Share files from Samsung Galaxy devices to Apple […]
'That money was earned': Sheila Cherfilus-McCormick counsel pushes back on allegations of siphoning money to campaign
But a bipartisan panel of lawmakers said much of defense at House Ethics trial 'strained credibility.'
Arkansas falls apart late in Sweet 16 loss to Arizona with ejection, bad fouls and a John Calipari technical
The Razorbacks unraveled fast on Thursday night in San Jose.
More concussions equal worse brain health 5 years after college sports
New concussion study deviates from the norm; most research in this space examines people in their 50s or 60s — decades after sport participation. Instead, this U-M study looks at college athletes in their 20s, and researchers already see the impact of concussion, which enables early intervention.
OU STEM students encourage curiosity in young minds for Atlanta Science Festival
Oglethorpe students participated in the Atlanta Science Festival, inspiring kids and their families with hands-on science activities.
Opinion | ‘No Kings’: Politics as Bad Group Therapy
Participants in the rallies accomplish nothing practical but feel heard, validated and affirmed.
Fathom Entertainment Announces Upcoming Retirement of CEO Ray Nutt
Specialty distributor Fathom Entertainment CEO Ray Nutt has shared with the company’s Board of Directors his plans to step down from his role and retire later this year after serving as the company’s lead executive for the past nine years. Currently anticipated to depart Fathom later this year, Nutt is expected to play an active […]
Mike Pence To Speak At UChicago’s Institute Of Politics In April
Pence will participate in a student-moderated panel and is expected to speak about the role of the executive branch, populism and more.
Photos: Pro Football Cares Sports Emergency Response Training at Raiders HQ
A Pro Football Cares Sports Emergency Response Training was held at Raiders HQ where athletic trainers and coaches were able to participate in a series of simulations on football equipment removal, cardiac arrest and exertional heat stroke.
Good Morning, Nashville! Talking Immigration Data Politics at Vanderbilt University
After a busy day on Capitol Hill yesterday, I landed in Nashville, Tennessee, last night for an exciting two days on campus at Vanderbilt University. Carwil Bjork-James, an anthropologist whose creative use of database construction to support critical scholarship resonates strongly with my own work, generously invited me to give a talk today about the politics of immigration data and to join a Wikipedia edit-a-thon tomorrow on the topic of immigrant detention. I encourage you to check out Carwil’s database project “Ultimate Consequences” about political deaths in Bolivia after 1982, and his book The Sovereign Street: Making Revolution in Urban Bolivia. My talk today is titled “Untangling the Messy Politics of Immigrant Detention Data.” I’ll focus on how immigrant detention data (not just detention centers themselves) become sites of controversy—from the collection and classification choices that shape what we can know, to the strategic withholding and distortion of data for political ends. Drawing on research spanning multiple administrations, I’ll trace how current data controversies in the second Trump administration connect to long-standing tensions in how we measure, interpret, and communicate about immigration. My goal is to move beyond simple partisan narratives and offer a practical guide for anyone working with immigration data to explore both the pitfalls to avoid and the creative opportunities for more transparent, rigorous public communication about immigration realities. If you are on campus, please stop by. Tomorrow I will join Carwil and Vanderbilt students for a Wikipedia Edit-a-Thon to edit and update Wikipedia entries related to immigrant detention with the latest robust information and data. This event is designed to orient participants into how to edit on Wikipedia, provide them with data-driven starter templates on detention facilities, and allow each person to produce an initial article on one element of the network of ICE facilities or one death in custody this year. The workshop is also a demonstration of how to use open data sources to build public knowledge—something I am deeply passionate about. Thank you to Vanderbilt University, the Spatial Histories series, and Carwil for hosting me. I would love to be a part of conversations and workshops related to immigration data on your campus. Students are really eager these days to have informed, critical, and data-driven explorations of our current immigration system. Reach out anytime if you want to discuss the possibility of bringing me to your campus. Subscribe
CPAC convention underway in Grapevine
The Conservative Political Action Conference convention is underway in Grapevine as grassroots activists across the world discuss policy ideas. Participants...
Shohei Ohtani’s Walk-Up Song Revealed Before Opening Day
For Los Angeles Dodgers star Shohei Ohtani's highly-anticipated 2026 season, he is reportedly going back to one of his old walk-up songs.
New bill could shield small business payroll cash, curb bank runs and aid community banks
A bipartisan group of lawmakers has reintroduced legislation that would expand federal deposit insurance coverage for certain bank accounts.
Trump Draws Bipartisan Backlash for Easing Oil Sanctions on Russia and Iran
Republicans and Democrats alike have criticized the Trump administration’s moves, taken to stabilize oil markets rocked by the war with Iran, warning that it is benefiting two U.S. adversaries.
Ashley Moody backs bipartisan bill to improve agricultural efficiency
'Our Florida universities are the best in the nation, and they should continue to lead in innovation.'
Bipartisan Support for Small Business AI Bill » CBIA
The Commerce Committee unanimously approved a bill supporting small business adoption of artificial intelligence technologies March 24.
Science Central’s planetarium opens Wednesday
Get ready to gaze up at the night sky inside 21Country’s only public planetarium. Science Central opened its highly anticipated project Wednesday.
Vandalia Health restructuring, eliminating north/south regions; Goldberg out
Changes come with President and CEO David Ramsey set to retire and anticipated impact from Medicaid changes.
Amazon Prime Day 'Big Spring Sale' Introduces Major Discounts on AirPods, iPads, AirTag, and Much More
Amazon this week is hosting a "Big Spring Sale," which includes deals and offers on everything from Apple devices to clothes, kitchen electronics, furniture, and much more. The new event is set to run through March 31, so you'll have a few days of discounts to shop, with new markdowns appearing every day. Note: MacRumors is an affiliate partner with some of these vendors. When you click a link and make a purchase, we may receive a small payment, which helps us keep the site running.
Moses Moody receives generous injury rehab offer from Arkansas' John Calipari
Golden State Warriors guard Moses Moody received an offer to rehab his knee injury at Arkansas by current head coach John Calipari.
The Student Entertainment Board to host their third drag show on March 27
SEB hosts various events throughout the school year, from all night parties and haunted houses to daily movie nights and more. As spring approaches and the clocks move forward, SEB shifts its focus to one of campuses most anticipated and vibrant events of the season: an Up All Night Drag Show. This year, the drag...
8 new emojis arrive in Apple iOS 26.4 update for iPhone users
Along with eight new emojis, the latest Apple iPhone and iPad software update includes new Apple Music features such as AI-generated playlists.
Apple releases iOS, iPadOS, macOS 26.4 with a long list of medium-size tweaks
The 26.4 updates are more significant than the last few updates have been.
Apple releases new updates for old versions of iOS, macOS, watchOS, more
Apple debuted new software updates today for old iOS, macOS, iPadOS, and watchOS versions, including iOS 18.7.7 and more.
UT Health San Antonio Multispecialty and Research Hospital treats first clinical trial participant in novel cancer study - UT Health San Antonio
Milestone paves the way for advancements in cancer care, innovation and patient care in San Antonio and South Texas. UT Health San Antonio Multispecialty and Research Hospital has enrolled and treated its first clinical trial participant in a novel cancer study, marking a pivotal moment for science and patient-centered cancer care in San Antonio and […]
CT bill seeks to reduce business tax on energy, boost state tourism and international trade
State lawmakers are considering a wide-ranging proposal aimed at reducing business costs, increasing municipal revenue and expanding international trade.
12 Life Science Startups Named to SLAS Europe 2026 Innovation Showcase Program
SLAS has named the 12 companies selected to participate in its Innovation AveNEW program at the SLAS Europe 2026 Conference and Exhibition.
Salamander Migration Has New Citizen Science Component
Each spring, blue-spotted salamanders emerge from their underground burrows at Presque Isle Park in Marquette and venture across the road to lay their eggs. Northern Michigan University students have been involved in conservation, data collection and public education efforts for this annual event, but this year, the general public is invited to play a more active role in salamander migration research. Northern Michigan University Biology Department Head Jill Leonard encourages community members to participate in the Marquette Citizen Science Project.
H-1B Health Care Workforce Bill Introduced
On March 17, Congressman Mike Lawler (NY-17) introduced the H–1Bs for Physicians and the Healthcare Workforce Act , bipartisan legislation with Reps. Sanford D. Bishop, Jr. (GA-02), Maria Elvira Salazar (FL-27), and Yvette Clarke (NY-09). This legisla...
Mobile sports betting may soon be legal across Wisconsin
Online sports betting could soon be legal in Wisconsin through a new bill passed by the state legislature, which awaits signature by Gov. Tony Evers. The bill passed with bipartisan support in the state Senate Wednesday, with 12 Democrats and nine Republicans voting in favor, according to the Milwaukee Journal Sentinel. The bill revises the...
Ecological and demographic drivers of Oropouche virus transmission
Nature Health - Nationwide analysis of 30,086 confirmed Oropouche virus cases in Brazil between 2014 and 2025 shows that rural municipalities had over 11-fold-higher incidence than urban areas and...
UFL 2026: Joel Klatt, Curt Menefee Return To Headline FOX Broadcast Team
Joel Klatt and Curt Menefee will once again lead FOX Sports' broadcast coverage for the highly anticipated third season of the UFL.
DarkSword exploit leaks on GitHub
The exploit is now publicly available on GitHub, increasing the urgency for older iPhones and iPads to run the latest available iOS and iPadOS versions.
Bill introduced seeks to ban sports bets on prediction markets
A bipartisan Senate bill introduced Monday seeks to ban prediction markets from allowing transactions that mimic sports betting.
Bipartisan Senate bill would ban sports betting on online prediction markets
Bill was introduced in the Senate on Monday as prediction market companies face greater scrutiny on state level
How to beat Gigantamax Pikachu: Best Counters & Guide
Gigantamax Pikachu is a Tier 6 Max Battle in Pokémon GO. It will cost 800 Max Particles to participate in this Max Battle, which will only be consumed if you defeat Pikachu successfully. Gigantamax Pikachu can be shiny from Max Battles. Being an type, it is only weak to type moves. Pikachu can be caught […]
Exclusive | Lawmakers to Introduce Bipartisan Bill Banning Sports Bets on Prediction Markets
A bipartisan pair of U.S. senators are introducing legislation to prohibit CFTC-regulated entities from listing contracts related to sporting events.
Winners and losers from first weekend of the NCAA tournament feature John Calipari, Darryn Peterson, Big Ten and blue bloods
Toto Wolff: Mercedes team principal wary of 'politics' as Charles Leclerc makes 'extremely strong' Silver Arrows claim
French Local Elections Are Yardstick for Far Right. Initial Results Are Mixed.
France’s municipal elections ended on Sunday evening. Full results were not expected for hours, but the first projections suggested the far right may not have made major gains.
Your Thymus and Your Healthspan
Our thymus gland plays a central role in the development or our immune system, specifically for supporting T cell development (how these cells got their name, maturation and differentiation in the thymus) and discriminating between self and foreign, non-self antigen proteins with production of dendritic cells. As we age, our thymus gland shrinks—the process known as involution—with progressive change from spongy to fatty tissue, with loss of functionality. But this process, with respect to timeline and extent, markedly varies from one person to the next. And to make things even more complicated, our thymus gland anatomy and precise location in the chest also is highly variable. So the famous Frank Netter diagrams from the 1960s (such as at left below) don’t capture the remarkable heterogeneity that a random set of 12 chest CT scans (below at right). What I consider as 2 landmark papers in Nature this week (here and here) used AI to quantify health of the thymus in 2 large cohorts, and then correlate the metric to a broad array of health outcomes. In this edition of Ground Truths, I’m going to cover three questions: (1) How was thymus health determined by AI?; (2) How is thymus health linked to key clinical outcomes? and (3) Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? Subscribe 1. How was thymus health determined by AI? This was accomplished by extensive work developing and validating an AI pipeline for 2 stages, the first for localization and segmentation of the thymus bed, and the second to quantify a digital marker, termed the thymic health score. There’s a lot to this algorithmic development, so I won’t go into all the details, but just provide a rudimentary outline of what was done. The 1st stage used supervised learning with 2 radiologists reviewing 2,461 chest CT scans. That work trained a 3D U-Net model to automatically identify the thymic bed’s 3D cropped region using center of mass coordinates, which reached 99.8% accuracy. The 2nd stage used a foundation model that was pre-trained with SwAV (which stands for Swapping Assignment between multiple Views), a self-supervised model, that generated a high-dimensional thymus representation of 4,096 features. That compares to the radiology reductionist and subjective scoring of 0 to 3 where 0 means the thymus is fully degenerated and fatty, and 3 is considered dense, intact glandular soft tissue. Notably, the self-supervised learning (SSL) performance was superior to supervised (AUC ~0.75 vs 0.55, respectively) reflecting the shallowness of the 0-3 classifier vs SSL’s holistic, self-taught AI. The thymic health score ranged from 0 to 100, with the highest number indexed to fully preserved thymic health. The algorithmic work extended to explainability with both Shapely value distribution, meaning the model was holistic not relying on any “magic” pixel, and occlusion sensitivity, demonstrating the model’s performance was not affected by ribs, sternum, lung tissue, but rather focused on the thymic bed directly. Below are a few saliency maps from the occlusion sensitivity that indicate the thymic bed focus, not affected by neighboring structures, using the jet color scale. Now the AI was ready for processing ~25,000 CT scans, each over 30 MB files, from the 2 large participant cohorts to provide a thymic health score, it did so in less than 14 hours, which is less than 2 seconds per scan! Share 2. How is thymus health linked to key clinical outcomes? The two cohorts were the National Lung Screening Trial, NLST (N=25,031) and the Framingham Heart Study, FHS (N=2,581) each with baseline demographics and long term follow up of >12 years for health outcomes. From the NSLT, you can see below that increased age and body-mass index were correlated to reduced thymic health. And, overall, men had reduced thymic health scores compared with women. There are a lot of graphs in the paper for outcomes, for both the NLST and FHS cohorts. To simplify the major outcomes, below is a composite Figure with striking reduction of all-cause mortality and for the different causes of death. The results were consistent between the 2 cohorts. For example, the cardiovascular mortality hazard ratio average was 0.57 in NLST and 0.38 in FHS (weighted to be 0.53 for the aggregate). The reduction of mortality also extended to digestive diseases and pulmonary disease (data not shown below). Lung cancer incidence was reduced by 36% for high vs low thymic health (Figure below, with a panel -incidence and b panel-mortality, adjusted for age, sex, BMI, smoking status). Notably, there was a smoker’s paradox: lower incidence and improved survival for lung cancer in smokers who had a high thymus health score. Smoking was associated with lower thymic scores whereas alcohol was not. Higher thymic health was linked to higher HDL cholesterol, lower triglycerides, lower fasting blood glucose, and lower systolic and diastolic blood pressure. Inflammation biomarkers, such as C-reactive protein and interleukin-6, were elevated in the people with lower thymic health scores. In their second paper, the same team looked at the relationship between thymic score and outcomes for 3,476 patients receiving cancer immunotherapy. The non-small cell lung cancer progression-free survival was reduced in patients with low thymic health score. A parallel relationship for survival was seen for other types of cancer including melanoma, breast, and kidney with a 44% lower risk among high thymic scores (Figure). A similar pattern was seen with different immune checkpoint inhibitors. The thymus health score outperformed programmed death ligand-1 (PD-L1)and tumor mutation burden (TMB) assay of the tumor and was an independent prognostic marker of progression-free survival. In this dataset, a direct connect with thymus score and adaptive immune function was noted with a correlation before cancer treatment for both T-cell diversity and thymus T-cell production (a metric known as T cell receptor excision circles). Thymus Removal Study There is a highly relevant citation about thymus function before moving onto ways to rejuvenate it. In 2023, a very important study of thymus removal during cardiothoracic surgery was published, with 1146 patients undergoing thymus removal vs 1146 matched controls (mean age 55 years). The adverse outcomes for thymus removal were striking, with a 2.9 higher risk of all-cause mortality and doubling of cancer incidence, 1.5 fold increase in cancer mortality, and 1.5-fold increase in autoimmune diseases. The immune function showed marked compromise after thymus removal, as reflected by CD4+ and CD8+ T cells (Figure below) Share Ground Truths 3. Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? In recent months we’ve learned a lot about the process of thymus involution and the pathways by which this may be modulated. Thymus involution is primarily due to loss to thymus epithelial cells (TECs) and there are 2 subtypes with different functions: the cortical, responsible for positive selection of T cells, and the medullary, for negative selection. When adipose tissue infiltrates the thymus, thymic adipocytes are pro-inflammatory, knocking out T-cell output. Likewise, systemic inflammation, or “inflammaging,” from smoking, obesity, and chronic stress promote thymic adipocytes. Now, from preclinical studies, we know about key pathways that account for these processes. Historically, back in 2014, FOXN1 was recognized as a single master transcription factor essential for TEC function, with studies in mice with forced FOXN1 upregulation leading to thymus regeneration. That laid the foundation for potential regrowth of quiescent thymus cells. It took awhile to find pathways to accomplish this goal and to even refute its role as the master regulator. The Liver-Thymus Axis Feng Zhang and his team recently showed that injection of an mRNA vaccine to the liver encoding DLL1, IL-7 and FLT3-L in combination, factors known to support thymopoiesis (Figure), successfully enhanced immune function in aged mice. However, the effect was transient. The FGF21 Story Two reports in 2025 addressed the thymus gland’s production of FGF21, a growth factor (fibroblast growth factor 21) and its control of thymus involution. This growth factor is also produced by the liver, but it doesn’t have impact on the thymus in aged rodent models. In contrast, The liver’s hepatocyte growth factor (HGF) has been shown to reverse senescent TEC structural changes. Growth hormone stimulates production of insulin growth factor-1 (IGF-1) in the liver and the thymus. Two small studies in human participants (TRIIM, for Thymus Regeneration, Immunorestoration, and Insulin Mitigation) of 6 and 50 people, respectively, treated with combined human growth hormone, metformin and DHEA, suggested the potential of slowing epigenetic aging and improving thymus mass and function. But the combination of drugs, small sample, and lack of controls make conclusions murky. Increased thymus FGF21 led to increased CD8 T cells in old mice and extended healthspan and improved physical performance. Building on the previous FOXN1 data, ablation of β-klotho, the obligatory co-receptor for FOXN1, accelerated thymic aging. The benefit to FGF21 was confirmed in a companion paper using an FGF21 knock-in mouse model showing thymus enlargement and increased TECs throughout the lifespan. (schematic Figure below). The accompanying editorial for these 2 papers speculated: “The proposed link between age-associated thymus involution and organismal aging is intriguing, and suggests we might seek to achieve systemic rejuvenation by counteracting thymic involution.” Other Factors Lessons from the Axolotl (Mexican Salamander) In an elegant set of experiments of the axolotl (Figure), known for its complete thymus regeneration after total surgical removal, mediators were identified. Surprisingly FOXN1 was dispensable. But midkine, a growth factor, appeared to be the driver, the initiator of thymus cell growth, survival, and repair. Other components that contributed were Postn+ (periostin-expressing mesenchymal niches) and Ccl19, a chemokine protein from the bloodstream. RANK and RANKL RANK (receptor activator of nuclear factor κB its ligand (RANKL) have been considered key regulators of medullary TECs. In a study of both aged mice and human thymus cell cultures, their key role was confirmed, with multiple benefits of resorting TEC function, recruitment of progenitor cells, and T cell development. Subscribe Summing Up This body of work strongly supports the health of the thymus gland as a critical regulator of human healthspan, not just a correlate or link. The new landmark studies are reinforced by the regenerative biology experimental models that have shown, via an array of mediators, that healthspan of aged mice is at least in part dependent on thymus gland function and its critical role for maintaining adaptive immunity. It sure seems that we’d be better off having an immune reservoir of naive T cells instead of a profile in older adults of exhausted, low quality, memory T cells, with a senescent phenotype. It is striking that we ignored the importance of the thymus gland for many decades. A wake-up call was the results of the thymectomy matched control study reviewed here, with the opposite of high thymic health score improved health outcomes. The convergence of AI and healthspan here is notable. The exceptional and laborious work for developing and validating (no less explaining) the AI to quantify thymus health set the foundation for probing the connect the major health outcomes in two cohorts with extensive follow-up. We’ve never had a way to meaningfully quantify the thymus gland before, so this represents important leverage of supervised, self-supervised, and transformer models. The study wouldn’t have been possible without AI. And it begs the question as to whether there are ways we can maintain our thymus at a high health score. But it’s not so simple to rejuvenate our thymus. There are multiple risks including the induction of autoimmunity, increasing the risk of cancer, and inducing a pro-inflammatory state. For example, factors that increase TEC proliferation could compromise the medulllary negative selection process and leak out auto-reactive (self-attacking) T cells. Thymic cells could be induced to proliferate, but we know, for example, that growth hormone and IGF-1 are associated with an increase risk of cancer. If thymus rejuvenation doesn’t clear out the accumulated senescent cells in older adults, then inflammation within the gland could block the production of TECs. Keeping these risks in mind, we now have identified many ways to keep our thymus healthy as we age that undoubtedly will be tested in clinical trials going forward. Ultimately, the benefit-to-risk tradeoffs will be defined. In the meantime, we have desperately needed an immunome. As I’ve stressed in multiple prior Ground Truths, we have no test in the clinic to assess a patient’s immune status! It was very encouraging for me to get an email from Hugo Aerts, the senior author of the landmark papers in the days after they were published: “I also wanted to say that your Substack on “Why We Need an Immunome” was inspiring for this work. We found it a very compelling perspective and greatly enjoyed reading it.” Just having an assessment of a person’s immune status via a chest CT scan, with millions of these performed per year, might help in guiding the right immunotherapy for cancer (e.g. more intensive, combinations for those with low thymic health scores) and help define people who are increased risk for age-related diseases of cancer, cardiovascular, and neurodegenerative. The main theme of Super Agers is that we now have many layers of data (genetics, proteins, biomarkers, organ clocks that can be integrated via multimodal AI) for us to define a person’s specific risk decades before one of these age-related diseases leads to symptoms, enabling prevention. From the new studies this week, we can add thymus health score as yet another way to understand a person’s risk, a window into their adaptive immune system and healthspan. And perhaps someday we will be able to safely rejuvenate the thymus, or maintain its health through one’s life, and use the thymus health score to monitor. NB: I wrote this post (No A.I.) A Quick Poll Loading... ********************************************************************* Thanks to Ground Truths subscribers (now > 200,000) from every US state and 212 countries. Your subscription to these free essays and podcasts makes my work in putting them together worthwhile. Please join! If you found this interesting PLEASE share it! Share Ground Truths Paid subscriptions are voluntary and all proceeds from them go to support Scripps Research. They do allow for posting comments and questions, which I do my best to respond to. Please don’t hesitate to post comments and give me feedback. Let me know topics that you would like to see covered. Leave a comment Many thanks to those who have contributed—they have greatly helped fund our summer internship programs for the past two years. It enabled us to accept and support 47 summer interns in 2025! We aim to accept even more of the several thousand who will apply for summer 2026.
Immigration crackdown impact on local Latino-owned businesses
Latino business owners told WRAL News that fear and uncertainty following a nationwide crackdown in immigration enforcement are keeping some families out of public spaces, leaving small businesses struggling to survive. This story was written by Oriana Torre, a senior graduating journalism student at the University of Florida, participating in the CBC-UNC News Media Multiplatform Fellowship.
iPad 12 With A18 Chip for Apple Intelligence is 'Still Coming This Year'
Apple has updated a wide range of products and accessories this month, but there is still no entry-level iPad 12 with Apple Intelligence support. Fortunately, Bloomberg's Mark Gurman today said an iPad with an A18 chip for Apple Intelligence is "ready to go" and "still coming this year". An earlier report from Macworld claimed that the iPad 12 will actually have an A19 chip.
Urgent Apple warning: Update your iPhone, iPad now
Roughly 25% of all iPhones are operating a version of iOS 18.
Report: New iPad with A18 chip still on track to launch in first half of 2026
As part of Apple’s week of product announcements earlier this month, many were hoping to see an update to Apple’s...
We Took Our Three-Year-Old On A Long Haul Flight, And It Was Amazing!
We took our three year old on his first long haul flight in nearly two years. It went so much better than I could have anticipated!
The Antidote to Our Growing Crises Must Transcend Politics
Each day, the challenges in our nation pile up. In just recent weeks, there has been the ongoing war in Iran and the Middle East, and ongoing debates about the growing negative impact of the Internet, looming AI challenges, and the Epstein files. The anticipation of divisive, even ugly, midterm elec...
Black Family Wellness Expo returns to Wichita, promotes health awareness for second year
Organizers say more than 40 different vendors participated in the expo.
Warriors' Stephen Curry set for major checkpoint in injury recovery
According to Steve Kerr, Golden State Warriors star, Stephen Curry will participated in a scrimmage on Sunday, March 22.
Milwaukee stair climb raises awareness for lung health and firefighters
The American Lung Association hosted its 18th annual stair climb in Milwaukee, where participants, including firefighters, climbed 30 stories to raise funds and awareness for lung health.
Young scientists shine at Regional Science Olympiad
Budding young scientists from throughout the region participated in the 41st Annual Stanislaus County Regional Science Olympiad on March 14 at Modesto Junior College.
Democrats block SAVE America Act amendment to bar transgender athletes in women’s sports
Senate Democrats voted Saturday to defeat a Republican-sponsored amendment to the SAVE America Act that would prohibit transgender athletes from participating in girls’ or women’s sports, an …
City of Santa Barbara Seeks Nominations for 2026 Business in Art Award
Nominations are now open for the 2026 City of Santa Barbara Business in Art Award, for local businesses that support artists
Big changes ahead for State Health Plan as trustees work to lower costs
The State Health Plan hopes to save significant money by steering plan participants to preferred providers.
Downtown Chico business owner voices concerns over street closures for events
A DOWNTOWN CHICO MERCHANT IS EXPRESSING CONCERN OVER THE IMPACT OF STREET CLOSURES FOR EVENTS -- ON THEIR BUSINESS. ACTION NEWS NOW REPORTER BELLA BARBOSA REPORTS FROM DOWNTOWN CHICO { "@context": "https://schema.org", "@type": "VideoObject", "name": "Downtown Road Closure Dilemma", "description": "A DOWNTOWN CHICO MERCHANT IS EXPRESSING CONCERN OVER THE IMPACT OF STREET CLOSURES FOR EVENTS -- ON THEIR BUSINESS. ACTION NEWS NOW REPORTER BELLA BARBOSA REPORTS FROM DOWNTOWN CHICO", "thumbnailUrl": "https://bloximages.newyork1.vip.townnews.com/actionnewsnow.com/content/tncms/assets/v3/editorial/c/47/c47e26d6-03c3-5f35-bf49-37925ab603d7/69bdedc4eb57d.image.jpg", "uploadDate": "2026-03-20T17:45:00-07:00", "contentUrl": "https://cdn.field59.com/KHSL/1774053903-6e1ef36dd09fbebf020833aee86b60da3b3cca3f_fl9-720p.mp4" } CHICO, Calif. - A downtown Chico business owner is voicing concerns about the impact of street closures for events on local shops. Leann Powell, owner of The Peddler’s Closet, expressed concern about events closing down streets downtown and bringing in food trucks and other shops’ products that directly compete with the brick-and-mortar stores in downtown Chico.Powell said an upcoming event held on a Saturday has brought up concerns for her and other business owners downtown, due to it being a busy day for businesses. "We're already struggling, and then to bring in more businesses on top of our businesses and shut our streets down is absolutely devastating," said Powell.Powell noted a decline in business during events like the Thursday Night Market, where street closures allow outside vendors to set up shop. She shared that while organizers for these types of events often offer booths to local businesses, it does not alleviate the burden."I don't really feel like that's a solution because you're bringing in other businesses, you're shutting the streets down. Yes, we can go down and set up a space, but then you've gotta pay somebody to run that space, plus run your own business for the day, and it's really not, it's really not helpful for us," said Powell.Applying for a street closure permit in Chico involves approval from the Public Works Department, the Chief of Police, and the Fire Chief. Permits can be denied only under a handful of circumstances, such as interference with first responders, previously scheduled construction, or existing permits for the same space.Mayor Kasey Reynolds addressed the issue, saying the city council has tasked staff with reviewing the municipal code for street closure permits with the goal of finding ways to minimize negative impacts on local businesses during events.Reynolds mentioned that any recommended changes might require further direction from the city council, depending on the extent of any changes recommended. googletag.cmd.push(function() { googletag.display('ad-1514992'); });
Press Release - Girls in STEM Program from Keystone Science School
Delivered in an all-girl+ learning environment, Keystone Science School’s Girls in STEM programs encourage participation, collaboration, leadership, and confidence.
Apple Has Unveiled 9 New Products This Month
Apple has unveiled a whopping nine new products so far this March, including an iPhone 17e, iPad Air models with the M4 chip, MacBook Air models with the M5 chip, MacBook Pro models with M5 Pro and M5 Max chips, the all-new MacBook Neo, an updated Studio Display, a higher-end Studio Display XDR, AirPods Max 2, and Nike Powerbeats Pro 2.
Brian Michael Bendis' Powers Animated TV Show in the Works
Bendis and co-creator Michael Avon Oeming are participating in the show's development.
Walz unveils tech tax in budget; bipartisan support emerges at Capitol
MPR News host Clay Masters and the politics team recap a week in state politics.
Politics Friday: Consumer safeguards gain bipartisan support at the Capitol
Friday at noon, MPR News politics editor Brian Bakst talks about proposals to protect consumers from scams and other ways Minnesotan’s might be swindled. Plus, a check-in with the state’s economic development commissioner.
Apple to Launch More New Hardware This April
Apple isn't done yet. After announcing seven new products in March – including the iPhone 17e, iPad Air, MacBook Air, MacBook Pro, MacBook Neo, Studio Display, and Studio Display XDR – the company has one more launch on the books in the coming weeks (as far as we know, at least). AirPods Max 2 go up for pre-order on March 25, with availability beginning in early April.
Towards responsible AI for mental health and well-being: experts chart a way forward
On 29 January 2026, WHO‑supported experts met at a TU Delft workshop to address the rapid, largely untested use of generative AI for mental health support. Participants warned of risks to well‑being, especially for young people, and called for stronger governance.
“Loyal Slaves” and Campfire Entertainment in Frank Vizetelly’s Confederate Camp
Frank Vizetelly’s illustration titled “Night Amusements in the Confederate Camp” appeared in the Illustrated London News on January 10, 1863. It was one among a number of wartime scenes that Vizetelly captured for the newspaper. Subscribe Following the war, the illustration appeared in a number of books, including John O. Casler’s Four Years in the Stonewall Brigade (1893) and Campfires of the Confederacy (1898) by Ben La Bree. The scene depicts a Confederate camp at night with an enslaved man, most likely a camp servant, performing a dance around a fire with the music provided by a soldier playing a banjo. Another enslaved man looks on at the right. Vizetelly likely witnessed the scene—one that would have been common throughout the war. It’s a wonderful example of the way in which Confederates—slaveowners and nonslaveowners alike—experienced the presence of slave labor in the army. Vizetelly was deeply sympathetic to the Confederate cause. His depiction of the enslaved man as more than happy to entertain the very people who were fighting to keep him enslaved was precisely the kind of image designed to reassure a British audience that slavery was benign, and by implication, that Britain need not feel morally troubled about recognizing or supporting the Confederacy. Share Just as importantly, the sight of a dancing slave reassured Confederates themselves that the institution of slavery remained secure even after President Lincoln signed the Emancipation Proclamation. I’ve come across this illustration many times before and I plan on using it in my next book project on the role of enslaved labor in the Confederate army during the Gettysburg Campaign, but this is not the reason I am sharing it with you today. It has to do with where I recently found it, which came as a complete surprise and is incredibly revealing. Let’s take a look.
City of Santa Barbara Seeks Nominations for 2026 Business in Art Award
Credit: CourtesyCredit: Courtesy (SANTA BARBARA, Calif.) – Nominations are now open for the 2026 City of Santa Barbara Business in Art Award, which
Be counted among the Capital Region’s top private companies
Each year, Business Report ranks the Top 100 Private Companies in the Capital Region — one of our most anticipated and widely read features. It’s the definitive look at the companies driving growth, investment and job creation across our market. If your company is privately held and headquartered in the Capital Region, we want to […]
Apple Health integrates with newly announced 'Perplexity Health' AI feature
Following yesterday’s Comet iOS browser release, Perplexity is back with another AI announcement: Perplexity Health. The new “suite of connectors”...
Tariffs and Mitigating Actions: Focus on the Business Law Section Report with Participation of the International Section and Real Property Law Section - New York State Bar Association
The Business Law Section presents this report on tariff policy developments since February 2025. IEEPA-based tariffs have imposed rates of 10% to 50% on nearly all trading partners. Litigants have challenged the asserted authority for these tariffs in federal court, with an appellate decision invalidating that authority now on appeal before the U.S. Supreme Court.
German Health Minister Nina Warken and WHO Hub in Berlin highlight 2025 achievements
Germany’s Federal Minister of Health, Nina Warken, visited the WHO Hub for Pandemic and Epidemic Intelligence in Berlin today to review progress and launch its 2025 Annual Report. The report highlights advances in using artificial intelligence, data science and pathogen genomics to strengthen global preparedness for future pandemics.In 2025, the WHO Hub in Berlin worked with more than 160 Member States and over 190 partners to help countries and organizations develop new systems and tools to detect and understand new public health threats as quickly as possible, whenever and wherever they occur.BMG to confirm whether they wish to contribute a quote. “Detecting outbreaks early is one of the most effective ways to save lives and prevent epidemics from becoming global crises,” said Federal Minister of Health Nina Warken. “Germany is proud to host and support the WHO Hub for Pandemic and Epidemic Intelligence. Its work strengthens our safety at home and helps protect people worldwide.”Artificial intelligence is increasingly transforming the detection of outbreaks. In 2025, the Hub launched an upgraded version of the Epidemic Intelligence from Open Sources (EIOS) system, which uses enhanced AI functions to scan global online information in real time and help experts quickly identify unusual health events. The system is now used by 120 countries.To better anticipate health threats, countries need information beyond traditional health data. The Hub supports countries in implementing Collaborative Surveillance, which integrates data on climate, animals, travel, and population movement to provide a more comprehensive and real-time understanding of health threats.The Hub also expanded global access to pathogen genomics, which helps scientists detect new pathogens, such as viruses and bacteria, understand how they spread and how dangerous they may become. Through the International Pathogen Surveillance Network (IPSN), the WHO Hub in Berlin worked with 309 partners in 101 countries to expand access to these technologies.“We are in a new era of global health threats, and we need new tools to face tomorrow’s challenges,” said Dr Chikwe Ihekweazu, Executive Director of the WHO Health Emergencies Programme. “The WHO Hub in Berlin helps countries use data and technology more effectively so they can identify risks earlier and respond faster. No country can address these threats alone. Strong cooperation remains our best defence.”“Berlin offers an ideal environment for our work. We collaborate closely with world-leading institutions such as the Robert Koch Institute and the Charité Center for Global Health,” said Dr Oliver Morgan, Head of the WHO Hub for Pandemic and Epidemic Intelligence. “Germany has supported the WHO Hub since its establishment, and we are pleased to welcome Federal Minister Nina Warken to the Hub today. This strong partnership helps us advance innovation in pandemic and epidemic intelligence and better support countries to prepare for future health threats.”The Hub is expanding the use of advanced analytics and mathematical modelling to forecast how outbreaks may develop and to assess which response measures are most effective. Through its Collaboratory, the Hub connects modelers and analysts with governments to ensure their work addresses real public health needs. In 2025, the community grew to 1300 members from 50 countries and 200 institutions. An AI-powered pandemic simulator, currently in the prototyping phase, will help decision-makers compare outbreak scenarios and help identify effective disease control measures.
Trump may push Japan for help with Iran war in White House meeting
U.S. allies such as Germany, Italy and Spain have ruled out participating in any Gulf mission.
Forum on harnessing Artificial Intelligence for health equity
Register to this forumOver the past decade, artificial intelligence (AI) has significantly evolved in complexity, performance, and utility. Its integration across a wide range of industrial sectors has accelerated, with healthcare emerging as one of the most transformative sectors. In this sector, AI has enabled high-impact applications – from enhancing the speed and accuracy of disease diagnosis and supporting clinical decision-making, to strengthening public health initiatives such as disease surveillance and workforce optimization. Moreover, AI holds immense potential to empower individuals, enabling them to take greater control of their personal health and well-being. Yet the central question remains: Who benefits, who is at risk, and do these innovations close or widen health inequities? While the potential of AI-enabled applications is substantial, many countries have approached their adoption with caution. This hesitancy stems from concerns about risks and benefits, including model bias, data breaches, privacy violations, and the erosion of professional skills due to over-reliance on AI. Additional barriers include inadequate data infrastructure and a lack of robust evidence on the most effective forms and interfaces of AI to enhance service delivery and system performance. Moreover, the rapid rise of Generative AI has introduced a heightened urgency for the development of comprehensive governance and ethical frameworks. The Asian Development Bank (ADB) Health Practice Team and Digital Sector, in collaboration with the World Health Organization (WHO) Regional Office for the Western Pacific, are convening the Forum on Harnessing AI for Health Equity on 25–26 March at ADB Headquarters. Senior health officials from 16 developing member countries (DMCs), alongside leading researchers, innovators, and policymakers from across Asia and the Pacific, will engage in discussions on how AI can be governed, financed, and scaled to deliver healthier lives for all. The forum is funded through the High-Level Technology Fund with support from the Government of Japan. Objectives The two-day forum aims to:Identify high-impact, evidence-based health AI use cases suitable for resource-constrained settings and map out a pipeline for potential supportIntroduce and validate the WHO's policy guidance on minimum necessary ecosystem for countries and institutions to self-assess readiness for AI adoptionObtain initial commitment from participating stakeholders to join a pilot regional initiative focused on data/model sharing for a priority health challengeEndorse a prioritized set of actionable policy recommendations focusing on governance, regulation, and sustainable financing necessary to scale high-impact health AI use cases in resource-constrained settings Target participants The forum will convene participants from 16 ADB DMCs including Bangladesh, Bhutan, Cambodia, Cook Islands, Fiji, Indonesia, Lao People's Democratic Republic, Mongolia, Nepal, Palau, Papua New Guinea, Philippines, Sri Lanka, Thailand, Uzbekistan, and Viet Nam. In addition, health system leaders and practitioners, private sector technologists, academic experts, representatives from civil society organizations, development partners, and philanthropic institutions engaged in AI for Health from Australia, the People’s Republic of China, Japan, Malaysia, New Zealand, Singapore, and the Republic of Korea will also be invited. SessionsDay 1 (25 March)Session 1: AI Use Cases for the Care Continuum: Improving Access and QualitySession 2: Adopting a risk-based approach for AI use case prioritizationSession 3: Establishing the Minimum Ecosystem for Implementation Risk ManagementSession 4: Future-Ready Health Workforce: Building Competency for Human-AI CollaborationDay 2 (26 March)Session 5: The Political Economy of AI in Health: Understanding Stakeholder Interests and their Impact on EquitySession 6: AI and Health Financing: Supporting Fair Coverage and ProtectionSession 7: AI Regulation and Oversight: Pathways for Different RealitiesSession 8: The Way Forward – Building Alliances and Regional Partnership How to registerThe forum will be held in a hybrid format. In-person attendance is by invitation only, while livestreaming of the forum will be available to the public. To register, please complete this form on or before 24 March 2026.Event organizers / partnersAsian Development Bank (ADB)WHO Regional Office for the Western Pacific High-Level Technology Fund (HLTF)ContactAkihito WatabeHealth Specialist, SD3-HSDawatabe@adb.org Jae Kyoun KimHealth Specialist, SD3-HSDjkkim@adb.org
Alumna supports students through sports
Alumna Chrystal Starling has built a dynamic career combining sports, education, and youth development. From Hokie student athlete to professional basketball player to assistant principal at a New York charter school, Starling credits writing and the influence of Nikki Giovanni for helping her find her voice and her purpose.
Should Congress Increase Taxes on Sports Betting?
Introduction Sports betting has skyrocketed in the United States since a 2018 Supreme Court ruling nullified a 1992 federal law that had prohibited sports gambling in all but a few states. Americans wagered $7 billion on sports in 2018 and a staggering $167 billion in 2025—a nearly 24-fold increase. The rise of sports-betting apps has … Continued
Here Are Apple's Release Notes for iOS 26.4
Apple provided developers and public beta testers with the release candidate versions of iOS 26.4 and iPadOS 26.4, which means we're going to see a public launch as soon as next week. The RC versions of the software include Apple's official release notes, giving us final details on what's included in the update.
Advancing Technology Innovation through the Rural Health Transformation Program
States are using the $50B Rural Health Transformation Program to expand telehealth, strengthen health IT systems, and pilot AI-driven innovations in rural care.
Ski For Life: Oregon adaptive sports program opens slopes to students with disabilities
An Oregon Adaptive Sports program allows young people with disabilities to participate in outdoors sports by providing them with adaptive equipment.