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Freddie Freeman might hit 5th against some left-handed pitchers
Whether it’s the Teoscar Tax or the Smith Levy, Freeman hasn’t batted lower than 4th since 2016
Can pesticide exposure before pregnancy affect babies’ health?
A study co-authored by UCLA researchers suggests certain chemical compounds correlated with lower newborn health scores.
Trump whistleblower Alex Vindman: ‘Sitting on the sidelines was not an option’
Democratic Senate hopeful says experience of being key witness in Trump’s first impeachment makes him right choice for Florida
Why the BTS Comeback Concert Was a ‘Disaster’ for Some Businesses
The turnout for the K-pop titans’ show was much lower than projected by officials, hitting the bottom line of some restaurants. Shares in the group’s management company also fell.
Your Thymus and Your Healthspan
Our thymus gland plays a central role in the development or our immune system, specifically for supporting T cell development (how these cells got their name, maturation and differentiation in the thymus) and discriminating between self and foreign, non-self antigen proteins with production of dendritic cells. As we age, our thymus gland shrinks—the process known as involution—with progressive change from spongy to fatty tissue, with loss of functionality. But this process, with respect to timeline and extent, markedly varies from one person to the next. And to make things even more complicated, our thymus gland anatomy and precise location in the chest also is highly variable. So the famous Frank Netter diagrams from the 1960s (such as at left below) don’t capture the remarkable heterogeneity that a random set of 12 chest CT scans (below at right). What I consider as 2 landmark papers in Nature this week (here and here) used AI to quantify health of the thymus in 2 large cohorts, and then correlate the metric to a broad array of health outcomes. In this edition of Ground Truths, I’m going to cover three questions: (1) How was thymus health determined by AI?; (2) How is thymus health linked to key clinical outcomes? and (3) Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? Subscribe 1. How was thymus health determined by AI? This was accomplished by extensive work developing and validating an AI pipeline for 2 stages, the first for localization and segmentation of the thymus bed, and the second to quantify a digital marker, termed the thymic health score. There’s a lot to this algorithmic development, so I won’t go into all the details, but just provide a rudimentary outline of what was done. The 1st stage used supervised learning with 2 radiologists reviewing 2,461 chest CT scans. That work trained a 3D U-Net model to automatically identify the thymic bed’s 3D cropped region using center of mass coordinates, which reached 99.8% accuracy. The 2nd stage used a foundation model that was pre-trained with SwAV (which stands for Swapping Assignment between multiple Views), a self-supervised model, that generated a high-dimensional thymus representation of 4,096 features. That compares to the radiology reductionist and subjective scoring of 0 to 3 where 0 means the thymus is fully degenerated and fatty, and 3 is considered dense, intact glandular soft tissue. Notably, the self-supervised learning (SSL) performance was superior to supervised (AUC ~0.75 vs 0.55, respectively) reflecting the shallowness of the 0-3 classifier vs SSL’s holistic, self-taught AI. The thymic health score ranged from 0 to 100, with the highest number indexed to fully preserved thymic health. The algorithmic work extended to explainability with both Shapely value distribution, meaning the model was holistic not relying on any “magic” pixel, and occlusion sensitivity, demonstrating the model’s performance was not affected by ribs, sternum, lung tissue, but rather focused on the thymic bed directly. Below are a few saliency maps from the occlusion sensitivity that indicate the thymic bed focus, not affected by neighboring structures, using the jet color scale. Now the AI was ready for processing ~25,000 CT scans, each over 30 MB files, from the 2 large participant cohorts to provide a thymic health score, it did so in less than 14 hours, which is less than 2 seconds per scan! Share 2. How is thymus health linked to key clinical outcomes? The two cohorts were the National Lung Screening Trial, NLST (N=25,031) and the Framingham Heart Study, FHS (N=2,581) each with baseline demographics and long term follow up of >12 years for health outcomes. From the NSLT, you can see below that increased age and body-mass index were correlated to reduced thymic health. And, overall, men had reduced thymic health scores compared with women. There are a lot of graphs in the paper for outcomes, for both the NLST and FHS cohorts. To simplify the major outcomes, below is a composite Figure with striking reduction of all-cause mortality and for the different causes of death. The results were consistent between the 2 cohorts. For example, the cardiovascular mortality hazard ratio average was 0.57 in NLST and 0.38 in FHS (weighted to be 0.53 for the aggregate). The reduction of mortality also extended to digestive diseases and pulmonary disease (data not shown below). Lung cancer incidence was reduced by 36% for high vs low thymic health (Figure below, with a panel -incidence and b panel-mortality, adjusted for age, sex, BMI, smoking status). Notably, there was a smoker’s paradox: lower incidence and improved survival for lung cancer in smokers who had a high thymus health score. Smoking was associated with lower thymic scores whereas alcohol was not. Higher thymic health was linked to higher HDL cholesterol, lower triglycerides, lower fasting blood glucose, and lower systolic and diastolic blood pressure. Inflammation biomarkers, such as C-reactive protein and interleukin-6, were elevated in the people with lower thymic health scores. In their second paper, the same team looked at the relationship between thymic score and outcomes for 3,476 patients receiving cancer immunotherapy. The non-small cell lung cancer progression-free survival was reduced in patients with low thymic health score. A parallel relationship for survival was seen for other types of cancer including melanoma, breast, and kidney with a 44% lower risk among high thymic scores (Figure). A similar pattern was seen with different immune checkpoint inhibitors. The thymus health score outperformed programmed death ligand-1 (PD-L1)and tumor mutation burden (TMB) assay of the tumor and was an independent prognostic marker of progression-free survival. In this dataset, a direct connect with thymus score and adaptive immune function was noted with a correlation before cancer treatment for both T-cell diversity and thymus T-cell production (a metric known as T cell receptor excision circles). Thymus Removal Study There is a highly relevant citation about thymus function before moving onto ways to rejuvenate it. In 2023, a very important study of thymus removal during cardiothoracic surgery was published, with 1146 patients undergoing thymus removal vs 1146 matched controls (mean age 55 years). The adverse outcomes for thymus removal were striking, with a 2.9 higher risk of all-cause mortality and doubling of cancer incidence, 1.5 fold increase in cancer mortality, and 1.5-fold increase in autoimmune diseases. The immune function showed marked compromise after thymus removal, as reflected by CD4+ and CD8+ T cells (Figure below) Share Ground Truths 3. Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? In recent months we’ve learned a lot about the process of thymus involution and the pathways by which this may be modulated. Thymus involution is primarily due to loss to thymus epithelial cells (TECs) and there are 2 subtypes with different functions: the cortical, responsible for positive selection of T cells, and the medullary, for negative selection. When adipose tissue infiltrates the thymus, thymic adipocytes are pro-inflammatory, knocking out T-cell output. Likewise, systemic inflammation, or “inflammaging,” from smoking, obesity, and chronic stress promote thymic adipocytes. Now, from preclinical studies, we know about key pathways that account for these processes. Historically, back in 2014, FOXN1 was recognized as a single master transcription factor essential for TEC function, with studies in mice with forced FOXN1 upregulation leading to thymus regeneration. That laid the foundation for potential regrowth of quiescent thymus cells. It took awhile to find pathways to accomplish this goal and to even refute its role as the master regulator. The Liver-Thymus Axis Feng Zhang and his team recently showed that injection of an mRNA vaccine to the liver encoding DLL1, IL-7 and FLT3-L in combination, factors known to support thymopoiesis (Figure), successfully enhanced immune function in aged mice. However, the effect was transient. The FGF21 Story Two reports in 2025 addressed the thymus gland’s production of FGF21, a growth factor (fibroblast growth factor 21) and its control of thymus involution. This growth factor is also produced by the liver, but it doesn’t have impact on the thymus in aged rodent models. In contrast, The liver’s hepatocyte growth factor (HGF) has been shown to reverse senescent TEC structural changes. Growth hormone stimulates production of insulin growth factor-1 (IGF-1) in the liver and the thymus. Two small studies in human participants (TRIIM, for Thymus Regeneration, Immunorestoration, and Insulin Mitigation) of 6 and 50 people, respectively, treated with combined human growth hormone, metformin and DHEA, suggested the potential of slowing epigenetic aging and improving thymus mass and function. But the combination of drugs, small sample, and lack of controls make conclusions murky. Increased thymus FGF21 led to increased CD8 T cells in old mice and extended healthspan and improved physical performance. Building on the previous FOXN1 data, ablation of β-klotho, the obligatory co-receptor for FOXN1, accelerated thymic aging. The benefit to FGF21 was confirmed in a companion paper using an FGF21 knock-in mouse model showing thymus enlargement and increased TECs throughout the lifespan. (schematic Figure below). The accompanying editorial for these 2 papers speculated: “The proposed link between age-associated thymus involution and organismal aging is intriguing, and suggests we might seek to achieve systemic rejuvenation by counteracting thymic involution.” Other Factors Lessons from the Axolotl (Mexican Salamander) In an elegant set of experiments of the axolotl (Figure), known for its complete thymus regeneration after total surgical removal, mediators were identified. Surprisingly FOXN1 was dispensable. But midkine, a growth factor, appeared to be the driver, the initiator of thymus cell growth, survival, and repair. Other components that contributed were Postn+ (periostin-expressing mesenchymal niches) and Ccl19, a chemokine protein from the bloodstream. RANK and RANKL RANK (receptor activator of nuclear factor κB its ligand (RANKL) have been considered key regulators of medullary TECs. In a study of both aged mice and human thymus cell cultures, their key role was confirmed, with multiple benefits of resorting TEC function, recruitment of progenitor cells, and T cell development. Subscribe Summing Up This body of work strongly supports the health of the thymus gland as a critical regulator of human healthspan, not just a correlate or link. The new landmark studies are reinforced by the regenerative biology experimental models that have shown, via an array of mediators, that healthspan of aged mice is at least in part dependent on thymus gland function and its critical role for maintaining adaptive immunity. It sure seems that we’d be better off having an immune reservoir of naive T cells instead of a profile in older adults of exhausted, low quality, memory T cells, with a senescent phenotype. It is striking that we ignored the importance of the thymus gland for many decades. A wake-up call was the results of the thymectomy matched control study reviewed here, with the opposite of high thymic health score improved health outcomes. The convergence of AI and healthspan here is notable. The exceptional and laborious work for developing and validating (no less explaining) the AI to quantify thymus health set the foundation for probing the connect the major health outcomes in two cohorts with extensive follow-up. We’ve never had a way to meaningfully quantify the thymus gland before, so this represents important leverage of supervised, self-supervised, and transformer models. The study wouldn’t have been possible without AI. And it begs the question as to whether there are ways we can maintain our thymus at a high health score. But it’s not so simple to rejuvenate our thymus. There are multiple risks including the induction of autoimmunity, increasing the risk of cancer, and inducing a pro-inflammatory state. For example, factors that increase TEC proliferation could compromise the medulllary negative selection process and leak out auto-reactive (self-attacking) T cells. Thymic cells could be induced to proliferate, but we know, for example, that growth hormone and IGF-1 are associated with an increase risk of cancer. If thymus rejuvenation doesn’t clear out the accumulated senescent cells in older adults, then inflammation within the gland could block the production of TECs. Keeping these risks in mind, we now have identified many ways to keep our thymus healthy as we age that undoubtedly will be tested in clinical trials going forward. Ultimately, the benefit-to-risk tradeoffs will be defined. In the meantime, we have desperately needed an immunome. As I’ve stressed in multiple prior Ground Truths, we have no test in the clinic to assess a patient’s immune status! It was very encouraging for me to get an email from Hugo Aerts, the senior author of the landmark papers in the days after they were published: “I also wanted to say that your Substack on “Why We Need an Immunome” was inspiring for this work. We found it a very compelling perspective and greatly enjoyed reading it.” Just having an assessment of a person’s immune status via a chest CT scan, with millions of these performed per year, might help in guiding the right immunotherapy for cancer (e.g. more intensive, combinations for those with low thymic health scores) and help define people who are increased risk for age-related diseases of cancer, cardiovascular, and neurodegenerative. The main theme of Super Agers is that we now have many layers of data (genetics, proteins, biomarkers, organ clocks that can be integrated via multimodal AI) for us to define a person’s specific risk decades before one of these age-related diseases leads to symptoms, enabling prevention. From the new studies this week, we can add thymus health score as yet another way to understand a person’s risk, a window into their adaptive immune system and healthspan. And perhaps someday we will be able to safely rejuvenate the thymus, or maintain its health through one’s life, and use the thymus health score to monitor. NB: I wrote this post (No A.I.) A Quick Poll Loading... ********************************************************************* Thanks to Ground Truths subscribers (now > 200,000) from every US state and 212 countries. Your subscription to these free essays and podcasts makes my work in putting them together worthwhile. Please join! If you found this interesting PLEASE share it! Share Ground Truths Paid subscriptions are voluntary and all proceeds from them go to support Scripps Research. They do allow for posting comments and questions, which I do my best to respond to. Please don’t hesitate to post comments and give me feedback. Let me know topics that you would like to see covered. Leave a comment Many thanks to those who have contributed—they have greatly helped fund our summer internship programs for the past two years. It enabled us to accept and support 47 summer interns in 2025! We aim to accept even more of the several thousand who will apply for summer 2026.
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Europe’s trade with Iran: Which countries do the most business with Tehran?
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Arizona softball walks off ASU to even series
Arizona softball earned a walk-off win over ASU Saturday night, though not the kind the Wildcats may have been expecting through the first part of the game. Arizona jumped out to an 8-0 lead, then allowed the Sun Devils to claw all the way back before Regan Shockey delivered a walk-off single in the seventh […]
Illinois State, Wake Forest battle for NIT quarterfinal spot
Another prolific scoring performance by Juke Harris allowed Wake Forest to keep its season alive and the best game of Landon Wolf's career enabled Illinois State to continue playing.
The perfect amount of wine to drink to lower your risk of dying from heart disease by 21%
Apple Wanted to Buy Halide to Boost iPhone 18 Pro's Camera App—Now There's a Lawsuit
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Apple TV Is Now Almost 20 Years Old
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Giant Study May Have Found The Ideal Amount of Coffee to Lower Stress
There's actually a sweet spot.
Giant Study May Have Found The Ideal Amount of Coffee to Lower Stress
There's actually a sweet spot.
6 Supplements That May Support Heart Health
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Big changes ahead for State Health Plan as trustees work to lower costs
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Wine vs beer vs spirits: Which is the least bad for your health?
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David Botstein, Gene-Mapping Pioneer, Dies at 83
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New study links more immigrants with lower elderly mortality
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Microsoft confirms a major Windows 11 update with faster Explorer, reduced Copilot, and more
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WordPress.com now lets AI agents write and publish posts, and more
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Apple Announces New Mac Sales Record Following MacBook Neo Launch
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Sports quiz of the week: youngsters, old timers, records, protests and posh grub
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Younger Chinese Americans are fighting to save traditions
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How did these flowers evolve to survive a megadrought?
A multi-year megadrought in the Western U.S. has claimed untold populations of wild plants. Amid the conditions, some have survived. Scientists have produced a stunningly complete picture about how populations of one particular flower – the scarlet monkeyflower – made it through. In a new study published in the journal Science, a team of scientists spent decades studying and sampling select populations of scarlet monkeyflowers in California and Oregon. Through genetic sequencing, the team discovered that the populations that did best went through genetic changes in a short time period. This is known as rapid evolution. The team found that three of the populations that recovered the BEST adapted their stomata to open less, so they could conserve more water. Stomata act like a plant’s pores, managing gas exchange and water loss. This allowed the scarlet monkeyflowers to hunker down in the drought and survive. Interested in more stories about rapid evolution? Email us your question at shortwave@npr.org.Listen to every episode of Short Wave sponsor-free and support our work at NPR by signing up for Short Wave+ at plus.npr.org/shortwave.Listen to Short Wave on Spotify and Apple Podcasts.This episode was produced by Jeffrey Pierre, Rachel Carlson and Hannah Chinn. It was edited by Christopher Intagliata and Rebecca Ramirez. Aru Nair checked the facts. The audio engineers were Becky Brown and Robert Rodriguez.
Humans and animals have the same preference in mating calls, citizen science experiment finds
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New business workshop coming to Lower Burrell
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This heart-healthy diet may also lower the risk of dementia
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Trading or gambling? How a new way to wager on sports is evading Nebraska’s betting ban
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Prediabetes Detection: A Critical Lever for Health Systems
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Ozempic Linked to Lower Risk of Plunging Mental Health in Study
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Cattle futures waiting on direct business to develop
At the Chicago Mercantile Exchange, live cattle were up and feeders were lower ahead of the week’s direct business and Friday’s Cattle on Feed report from the USDA. April live cattle closed $.17 higher at $235.40 and June live cattle closed $.30 higher at $235. April feeder cattle closed $.97 lower at $353.82 and May […]
General Mills offloads Brazil business as sales dip
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3D printing business taking off in Chesterfield
Originally built on a $5,000 grant from the University of Missouri’s Entrepreneur Quest Award, followed by $50,000 in Arch Grant Funding, Printerior has its eyes set on continued growth with
A Look At Tencent Music Entertainment Group (TME) Valuation After Optimism Around Earnings And Analyst Upgrades
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Cuban Americans Will Be Allowed to Own Businesses in Cuba, but Is That Enough?
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Your daily coffee may be protecting your brain, 43-year study finds
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A unique combo of two top diets slowed brain aging by over 2 years
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Two men have been charged with running a fraudulent contracting business in Lower Merion
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March Madness 2026: BYU, South Florida among NCAA Tournament bracket sleeper teams
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The restaurant reservation wars show no signs of slowing down
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Boards protected CEO bonuses as tariffs threatened business. Now, as Iran disrupts trade, CEOs may get more protection
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Pair accused of operating fake contracting businesses in Lower Merion Township
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US National Academy of Sciences awards four Spaniards for explaining how life escaped an evolutionary dead end
After research spanning more than 30 years, Jordi Bascompte, Bartolo Luque, Fernando Ballesteros, and Enrique Muro managed to explain the abrupt change in living beings that allowed the appearance of plants and animals, including humans
Scientists Find First Evidence of "Evolutionary Rescue" In The Wild
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China woman uses AI-made man to lecture on respecting science, rejecting superstition
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The Latest: ‘One Battle After Another’ takes best picture
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Winter Sports and Lower Limb Motor Disability
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2026 Selection Sunday Live Updates: Men's, Women's NCAA Tournament Brackets
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Rare blower RTX 5090 AI card repaired by cutting memory from 32GB to 28GB
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Top 5 most improved teams during NFL free agency, including the lowly Jets
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This Week in Gaming (Week 12)
Welcome to week 12 and a jam cram packed week of rather big new releases. We kick off this week with a AAA release which is an open-world action-adventure that supposedly takes place in a desert, yet apparently not at all. This is followed by a very blocky looking RPG, several deadly sins, a cube of...
Oddsmakers project tough Ohio State season ahead
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Sen. Booker demands ‘accountability’ for the war in Iran
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FSG defends its record in Pittsburgh as sale of Penguins nears
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White House advisor calls for food pyramid reform to lower healthcare costs
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Linux Finally Catches Up to Windows with a Game-Changing Performance Feature
For years, the Linux kernel’s scheduler has been world‑class at balancing loads, yet it missed a crucial, cache‑aware instinct. In modern multi‑core systems, that gap can turn into measurable latency, especially when threads bounce between cores that don’t share the same cache. A new upstream feature, often called Cache Aware Scheduling, is now set to change that equation. A cache‑savvy scheduler arrives At the heart of any OS, the scheduler decides which thread runs where and for how long. In modern CPUs, small private caches (L1 and L2) sit beside each core, while a larger Last Level Cache (LLC, typically L3) is shared among groups of cores. When a task migrates across LLC boundaries, its warm data may vanish from the cache, forcing slower trips to main memory. Cache Aware Scheduling keeps related tasks close to their shared LLC, reducing destructive migrations. By respecting cache topology, the kernel minimizes cold‑start penalties and preserves locality that many workloads desperately need. The result is less thrashing, fewer memory stalls, and more consistent throughput. "Keep tasks close to their data, and the system will keep performance close to its peak." Why this narrows the Windows gap Windows has long leaned on topology‑aware, cache‑sensitive heuristics, especially since the Windows 10 era. That advantage helped Microsoft handle hybrid designs with P‑cores and E‑cores, plus complex cluster and NUMA layouts. With cache awareness integrated upstream, Linux brings parity to this vital dimension, without sacrificing its trademark flexibility. The Linux approach remains deeply configurable, reflecting the ecosystem’s breadth across servers, desktops, and embedded devices. It layers atop existing NUMA‑balancing and energy‑aware logic, refining placement rather than reinventing the wheel. Crucially, it aligns scheduling with the hardware’s real shape, not just with abstract CPU counts. Real‑world gains and who benefits Early tests on Intel Sapphire Rapids platforms point to gains in the 30–45% range for select workloads. Those wins appear in cache‑sensitive tasks like in‑memory analytics, high‑thread compilation, and microservices with tight working‑sets. Games and latency‑bound engines can also feel steadier frame‑times, especially when threads share hot assets. The benefits extend to AMD’s 3D V‑Cache parts, where keeping threads near enlarged cache slices prevents needless misses. Hybrid x86 designs with performance and efficiency cores further profit when cache and core roles are scheduled in concert. Even handhelds running SteamOS can squeeze more out of limited power, translating cache locality into smoother play. Key advantages include: Lower end‑to‑end latency Fewer expensive misses to RAM Better multi‑socket and NUMA behavior Improved energy efficiency More predictable QoS under mixed loads Stronger scaling on dense servers Caveats, tuning, and rollout No scheduler change is purely free, and trade‑offs still exist. Favoring locality can reduce cross‑cluster balance if limits are set too tight. Likewise, fairness and utilization must remain healthy, especially under heterogeneous, bursty workloads. Linux’s implementation is designed to be measured and tunable, not a blunt instrument. It cooperates with energy‑aware scheduling for mobile efficiency, and with NUMA‑balancers on big iron. Expect architecture‑specific refinements as vendors surface richer topology hints and cache‑sharing maps. Upstream integration has begun, with broad distribution adoption likely over the next cycles. Many users will encounter the change through standard kernel updates in 2025–2026, depending on distro cadence. Server‑class kernels may enable or tune it sooner for targeted fleets where cache locality is money in the bank. How to think about performance impact Cache Aware Scheduling amplifies gains when your workload is both CPU‑bound and cache‑sensitive. Think tight inner loops, hot code paths, and datasets that fit snugly in shared LLC. It’s less dramatic for I/O‑bound services or memory‑hungry tasks that blow past cache capacity. Still, even modest locality improvements often translate into smoother tail‑latency, which is where user experience and SLAs typically break. Developers can further help by pinning related threads, batching work, and aligning data to reduce cross‑cluster chatter. The scheduler’s new awareness works best when applications expose good hints. The bottom line By understanding and honoring cache topology, Linux removes a subtle yet costly bottleneck. The kernel’s smarter placement keeps hot data hot and work near where it belongs. That narrows a long‑standing gap with Windows, while preserving the openness and tunability Linux champions. For gamers, creators, and operators, the payoff is practical: more consistent frames, faster builds, and snappier services. For the ecosystem, it’s another step toward hardware‑savvy scheduling that turns transistor complexity into real‑world speed. And for Linux itself, it’s a timely upgrade that matches today’s silicon with tomorrow’s expectations.
Congressman Scott Perry tours Camp Hill business with Small Business Administrator Kelly Loeffler
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Millions more people may need to start cholesterol-lowering medications as young as their 30s. Here’s why
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Tottenham Hotspur, a "Big Six" club, should be contending for trophies. Instead, it might drop out of the Premier League altogether.
F1 set to cancel Bahrain and Saudi Arabian Grands Prix due to war in Middle East as 2026 calendar to drop to 22 races
Formula 1 is set to cancel the Bahrain and Saudi Arabian Grands Prix by the end of this weekend due to ongoing Middle East conflict; watch the Chinese GP Sprint live on Sky Sports F1 at 3am on Saturday, followed by full qualifying at 7am
WA residents may soon be able to bet on UW, WSU, Gonzaga sports
Under the measure, bettors would be allowed to wager on the outcome of games or matches featuring schools from Washington.
US economic growth revised lower in fourth quarter
The U.S. economy grew at a rate of 0.7% in the fourth quarter of 2025, according to a second estimate released on Friday by the Bureau of Economic Analysis.
At the Winter Paralympics, some athletes have found business opportunities
At the Winter Paralympics, athletes with prosthetics often modify them to fit their bodies more precisely. That has led to some competitors starting their own businesses to help fellow amputees.
At the Winter Paralympics, some athletes have found business opportunities
At the Winter Paralympics, athletes with prosthetics often modify them to fit their bodies more precisely. That has led to some competitors starting their own businesses to help fellow amputees.
Sports quiz of the week: world records, wrong turns and wild scenes
Have you followed the big stories in football, winter sports, cricket, rugby, horse racing, athletics, basketball and F1?
‘We want Mikie Sherrill to save our hospital.’ N.J. community’s final rallying cry for health care.
Mayor James Solomon said Jersey City will be left a health care desert if the ER is allowed to close Saturday as planned.
Eleven business students named Spears Distinguished Seniors for 2025-26 academic year
Oklahoma State University’s Spears School of Business has named 11 students Spears Distinguished Seniors for the 2025-26 academic year.
Rapid evolution helped a wildflower survive California’s megadrought
Wild scarlet monkeyflowers in California survived a historic drought by relying on a rapid evolution, marking the first time the process has been observed in the wild.
Fenway Sports Group should donate part of Penguins sale profits to lower Hill District, SEA says
As Fenway Sports Group completes its sale of the Pittsburgh Penguins, members of the Sports and Exhibition Authority board called on the organization to...
Aging could slow down with one common daily habit: 'Live longer and better'
Daily multivitamin use slowed biological aging by about four months in a two-year study of nearly 1,000 participants, with the biggest benefits in older adults.
City says no more Old Joliet Haunted Prison, but entertainment company wants to return
The Old Joliet Haunted Prison run by Thirteenth Floor Entertainment since 2020 during the Halloween season will not return this year.
Costco member sues for share of tariffs refund
A Costco shopper is suing the wholesale club for a piece of any tariff refunds after CEO Ron Vachris pledged "lower prices and better values."
Chain favorite replacing Wawa at Trexler Business Center in Lower Macungie
Qdoba Mexican Eats is launching its third location in the Lehigh Valley, operating by the same group running the Whitehall and Westgate Mall sites.
An NIH whistleblower warning
The doctors behind the telehealth GLP-1 boom, a men's health office moment, and other health news
Should You Lower Your Bedroom Temperature for Better Heart Health?
New research suggests that higher bedroom temperatures may be linked to a higher heart rate and lower heart rate variability.
The Neighborhood Politics of a Massive Home Addition
As municipalities encourage more housing density, neighbors debate what kind of construction should be allowed.
What's shaping the K-shaped economy: Spending, jobs, income, credit
The K-shaped economy is growing more lopsided. Wealthy Americans splurge on travel and events; lower- and middle-income people cut back on groceries.
Treasury’s FinCEN Whistleblower Portal Presents Business Risks
The Treasury Department’s new whistleblower portal is likely to increase enforcement risks for companies that must comply with the Bank Secrecy Act, US sanctions, and beyond.
I’m an NIH whistleblower. The scientific community cannot afford to avoid politics
“Scientists are often encouraged to avoid politics. But this advice is outdated, if it was ever correct in the first place,” writes Jenna Norton, NIH whistleblower.
Mamdani addresses residents in third 'Rental Ripoff' hearing
This was the first time New York City housing residents were allowed inside.
A small US grocer is calling out the lower prices at big chains
It is 'impossible for us to compete', says the boss of a New York grocery store.
Billionaires and businesses fuel growing exodus from blue states
Major corporations and billionaires are permanently relocating from blue states to red states, driven by lower taxes and business-friendly policies.
Republicans Concede They Need a Pivot on Immigration Ahead of Midterms
In public comments and private meetings at a House G.O.P. retreat, top officials allowed that President Trump’s immigration crackdown had hurt the party and that they needed a course correction on the issue.
‘The Floor’: Season 5 Premiere Date & ‘Game-Changing Twist’ Revealed
Find out what's new when the Rob Lowe-hosted show returns.
Pokémon Pokopia is such a "viral hit" that it's making Nintendo's share price surge (after months of going down)
Pokémon Pokopia is huge and a viral hit already. Moreover, it's boosted Nintendo's share price and Switch 2 sales following a few slower months.
Report: Scott County Jail staff ignored inmate’s mental health crisis
Scott County Jail workers allowed a woman in mental distress to repeatedly bang her head against cell walls without intervening, a report alleges.
How to Solve One of the Most Expensive Problems in Employer Healthcare
A small share of employees drives a disproportionate share of employer health-care spending: They are patients whose complex conditions go undiagnosed as they cycle through a fragmented care system. A diagnostic-focused “center of excellence” model—such as the Mayo Clinic Complex Care Program—offers a different approach: coordinated, multidisciplinary evaluations that identify the right diagnosis quickly. Evidence from employer claims shows that earlier, accurate diagnoses can improve outcomes, reduce unnecessary procedures, and lower costs by shifting care from repeated testing toward targeted treatment.
Hurry! These five-star Sennheiser headphones are at their lowest-ever price for Amazon's Spring Deal Days
The Momentum 4 Wireless for just £161, if you're quick
Has Tudor 'completely destroyed' Kinsky's career?
Tottenham replaced goalkeeper Antonin Kinsky in the 17th minute of their Champions League last-16 tie at Atletico Madrid after conceding three goals. The Czech Republic international, 22, endured a nightmare start and interim boss Igor Tudor quickly replaced him with Guglielmo Vicario. BBC Sport's chief football writer Phil McNulty, who was at the match, said he was not sure he had "ever witnessed anything quite like this" after Spurs' series of mistakes was followed by Tudor's decision to take Kinsky off.
Americans are increasingly worried about voting, new poll shows
Americans’ confidence that their elections will be run fairly has dropped to its lowest point in years, according to a new PBS News/NPR/Marist poll.
My stay in Switzerland’s oldest mountain inn – where winter sports aren’t allowed
Perched high above a frozen lake, Grimsel Hospiz in the Bernese Oberland offers an unusual winter escape, with gourmet food, a hot tub, star-filled skies and no distractions
Whistleblower claims ex-DOGE member says he took Social Security data to new job
The Social Security inspector general’s office is investigating allegations that the former DOGE engineer took sensitive data on a thumb drive in a major potential security breach, said people familiar with the process.
Asus releases new 14-inch gaming laptop in the US with AMD Strix Halo
Asus has finally started selling its first AMD Strix Halo gaming laptop in the US. Equipped with a 165 Hz display, the new laptop also features a 73 Wh battery with 100 W charging via USB Type-C. Unfortunately, Asus has decided against offering a 64 GB RAM variant in the US, which would have allowed the TUF Gaming A14 FA401EA to assign up to 48 GB VRAM to its Radeon 8060S iGPU.
The Witcher 4 Gets Updated NVIDIA RTX Mega Geometry: Higher Framerates, Lower VRAM Use
NVIDIA has announced that CDProjectRed's upcoming title, The Witcher 4, will leverage its updated RTX Mega Geometry technology.
Scientists discover molecule that stops aggressive breast cancer in its tracks
Scientists at Oregon Health & Science University have developed a new molecule that could open the door to treating triple-negative breast cancer, one of the most aggressive and difficult-to-treat forms of the disease. The compound, called SU212, targets and disables a key enzyme that cancer cells rely on to fuel their growth. In tests using humanized mouse models, the molecule caused tumors to shrink and slowed the spread of cancer by forcing the enzyme to break down.
Daily Multivitamins Slow Aging, Clinical Trial Finds
By Dennis Thompson HealthDay ReporterTUESDAY, March 10, 2026 (HealthDay News) — The health boost from daily multivitamins might actually extend to how quickly a person ages, a new study says. Researchers found slower “wear and tear” biological aging among seniors after two years on a multivitamin,
Get to know Aaron Parnas – the liberal social media star making waves
At 26, Aaron Parnas has built a 7.5‑million‑follower audience delivering news with his catchphrase, “We have some news right now.”
