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MVRC launches Valley Business Works Foundation
For its inaugural year, Valley Business Works will focus on the creation of the Mon Valley Youth Leadership Academy.
Can Jaylen Brown lift the Sixers and prove his doubters wrong? Breaking down Philadelphia's big swing
Building connections across molecular life science
ASBMB President Ed Eisenstein reflects on how the society shaped his scientific career and outlines his vision for expanding connections across academia, industry and government to accelerate discovery, translation and community-building.
The deal also allows the Grizzlies to preserve its …
The deal also allows the Grizzlies to preserve its …
Green Bay Packers Named Potential Suitor for RB Najee Harris
Should the Green Bay Packers sign veteran RB Najee Harris?
Nearly 450,000 New Yorkers Are Losing Health Coverage July 1
Thousands of low-income New Yorkers are among the first to feel the impacts of the "Big Beautiful Bill."
Dr. Steve Grice appointed Interim Dean of TROY’s Sorrell College of Business
Troy University alumnus and former director of TROY’s William H. Carr School of Accountancy Dr. Steve Grice has been appointed interim dean of the Sorrell College of Business. Grice’s appointment, which is effective July 1, comes after Dean Dr. Judson Edwards was named as the University’s interim Senior Vice Chancellor for Academic Affairs and Provost. ...Read More
Nationals pitcher Cade Cavalli apologizes for calling Willson Contreras 'boy' after strikeout: 'It'll never happen again'
NYC Health + Hospitals/Queens Receives the PRISM Award from the Academy of Medical-Surgical Nurses
NYC Health + Hospitals/Queens today announced that its Medical-Surgical Unit, 5B East, has received the prestigious PRISM Award from the Academy of
With DeGette’s loss, Raul Ruiz eyes her job on a powerful health panel - Live Updates
The Energy and Commerce Health Subcommittee has jurisdiction over HHS, Obamacare, Medicare and Medicaid.
With DeGette’s loss, Raul Ruiz eyes her job on a powerful health panel - Live Updates
The Energy and Commerce Health Subcommittee has jurisdiction over HHS, Obamacare, Medicare and Medicaid.
ASU scientists unveil new methods to extract reliable truth from imperfect data
Scientists at Arizona State University are advancing how they interpret complex, imperfect data — challenging long-standing assumptions in fields ranging from imaging to cellular biology. In two papers published in Nature Communications and Proceedings of the National Academy of Sciences, the team introduces fundamentally new approaches to solving “inverse problems,” where researchers work backward from noisy observations to uncover the underlying reality.
Court backs state monitor in Orange County IDA lawsuit
A state Supreme Court dismissed a county IDA suit seeking to vacate a state monitor's "veto" of an $80 million tax break for a proposed Amazon center.
Exploreum Science Center kicking off special appreciation week
The Exploreum is celebrating the people who make our community stronger from July 6th to the 11th.
Dallas Cowboys 2026 NFL Season Preview
Cowboys owner Jerry Jones has repeatedly said he would write an “embarrassing” check to win another Super Bowl. Since 2013, the Cowboys have not participated in the first wave of free agency. Despite Jones’ vow to “bust the budget” in the 2026 offseason, the Cowboys again stood pat for most of free agency.
Virginia’s Styrofoam ban takes effect, Roanoke businesses face rising costs
Macado’s restaurants say the switch will cost more than $115,000 a year
Why high earners are rushing to use this vacation-rental tax break
The Big Beautiful Bill made a tax loophole permanent for Airbnb investors. Here's how they're getting the IRS to fund their downpayments.
Academy Sports + Outdoors coming to Siloam Springs
Marc Hayot/Herald-Leader Construction workers prepare the ground to build the new Academy Sports + Outdoors in between the Walmart Supercenter and Lowe's Home Improvement on June 24. An opening date has not been set, said Kelley Jones, senior external communications specialist for Academy Sports + Outdoors.
Enrollment in Affordable Care Act health plans drops by 3M, HHS data reveals
The Trump administration said the reduction can be attributed to a cleanup of fraud, waste and abuse, but the real reason extends back to enhanced subsidies put in place during the COVID-19 pandemic.
Democratic socialist Melat Kiros poised to become the first Gen Z woman in Congress
Kiros, a political newcomer, topped 15-term-incumbent Diana DeGette in the Democratic primary in Colorado's 1st Congressional District, a reliably blue House seat.
Nearly 3 Million Fewer People Secured Marketplace Coverage After Republican Health Care Cuts, New Data Show
This is the largest drop in effectuated enrollment since the ACA marketplaces were established.
Seven gastrointestinal illness cases linked to Seattle sushi restaurant, health officials say
Seven people reported getting sick after eating at the Sushi%AYCE/All You Can Eat restaurant in Seattle’s Chinatown International District.
July 2 Vallejo/Vacaville Arts-Entertainment Source: Activities
July 2: Benicia Farmers Market, 4 p.m., Downtown Benicia at First Street. July 2: Bunco Night, Vacaville Museum Guild, 5 p.m., 213 Buck Ave. To purchase tickets online, access Vacavillemuseum.org/events/. July 2: GVRD Bite Nite: 5…
Dartmouth Health hires new COO
Dr. Jonathan Welch, experienced in academic and rural health, joins Dartmouth Health as COO, replacing Patrick F. Jordan III.
Contract extension marks 'fresh start' for Taylor
Midfielder Fraser Taylor is relishing a "fresh start" under new St Mirren boss Craig McLeish after signing a two-year contract extension. The 23-year-old academy graduate, whose deal now runs to summer 2028, made his first-team debut in 2022 and featured 13 times for the Buddies last season before joining Partick Thistle on loan in January. "I'm really pleased, since the new manager has come in, he spoke to me on the off-season, and his ideas really suit the way I like to play," said Taylor.
Jazz Under the Stars returns August 6
KCCK's Jazz Under The Stars celebrated the station's 50th anniversary last year by reuniting some of Iowa's best-known jazz, blues and R&B performers. Iowa's Jazz Station kicks off its second
Marlee Matlin Signs With Gilbertson Entertainment (EXCLUSIVE)
Academy Award winner Marlee Matlin ('CODA') has inked with Gilbertson Entertainment for management.
Millions drop Obamacare health coverage after subsidies expire and costs rise
Experts share why millions of people lost their Affordable Care Act health insurance plans this year after federal subsidies expired.
Millions drop Obamacare health coverage after subsidies expire and costs rise
Experts share why millions of people lost their Affordable Care Act health insurance plans this year after federal subsidies expired.
PAHO expands health response as Venezuela faces mounting health risks after devastating earthquakes
Caracas, Venezuela/Washington, D.C., 30 June 2026 (PAHO) – The Pan American Health Organization (PAHO) is expanding its support to Venezuela's Ministry of Health following the two powerful earthquakes that struck the country on 24 June, deploying technical experts, coordinating international Emergency Medical Teams (EMTs), assessing damaged health facilities, and mobilizing emergency medical supplies to support lifesaving care and reduce the risk of disease outbreaks.
Hormel Foods sells Brazil business
Domestic food producer Zanchetta Alimentos is acquiring the business operating under the Ceratti brand.
El Boletín newsletter: An earthquake shakes Venezuela’s political reset
Our correspondent in Caracas reports on how disaster is testing an already fragile country
Opinion | Protect the workers who protect our health
Massachusetts lawmakers should pass bipartisan workplace violence reforms before the legislative session ends.
Developer addresses community concerns around Franklin youth sports complex project
The project, proposed by developer BLVD Capital, would transform Brownland Farm, a 233-acre property on Hillsboro Road just outside downtown Franklin, into “The Banks at Brownland.”
Faculty and staff recognized for professional excellence
Binghamton University faculty and staff have been recognized for their professional excellence and dedication to their work by the SUNY chancellor, the University, and the University’s provost and executive vice president for academic affairs.
RWJBarnabas Health Board Chair, Susan Reinhard, Designated a Living Legend by the American Academy of Nursing
Susan C. Reinhard, PhD, RN, FAAN, Chair of the Board of Trustees for RWJBarnabas Health, the largest, most comprehensive academic health care system in New Jersey, has been designated by The American Academy of Nursing as a Living Legend.
Hood College Launches Accelerated One-Year Master of Science in Environmental Biology Track
Beginning in Fall 2026, Hood College's Graduate School will offer a new accelerated, 30-credit track within its Master of Science in Environmental Biology program, providing students with a pathway to earn their degree in just one academic year while gaining valuable hands-on research experience.
About 3 million people have dropped Obamacare health coverage after subsidies expire and costs rise
The Department of Health and Human Services suggests the 13% drop is due to a federal crackdown on fraudulent enrollmentut, but health analysts believe it's more likely related to the Jan. 1 expiration of federal subsidies.
FDLE Relocates Orlando Toxicology Lab to UCF, Strengthening Partnerships and Research
Expansion with the UCF Academic Health Sciences Campus in Lake Nona strengthens the Florida Department of Law Enforcement's forensic opportunities.
Nhouyvanisvong, Green Among Attendees at NCAA Career in Sports Forum
Macalester College rising senior Adi Nhouyvanisvong (Wayata, Minn./Minnetonka) of the women's soccer team and rising junior Jay Green (Roseville, Minn./Mounds Park Academy) attended the NCAA's Career in Sports Forum, held May 27-30 at the NCAA headquarters in Indianapolis, Ind.
New data shows consumers dropped health coverage after Republicans let subsidies expire
Republican officials don’t deny the accuracy of the data, though they’ve repeatedly tried to argue that the reduction is a positive development. It’s not.
Wa-Hi junior Lars Sandven selected for prestigious national science camp
The residential summer camp provides academic and leadership experience in STEAM fields.
UC Berkeley is establishing the Nancy Pelosi Institute to address democracy's challenges
Former House Speaker Nancy Pelosi and the University of California, Berkeley, are partnering to form a new nonpartisan academic institute they say will be dedicated to strengthening democracy
UC Berkeley is establishing the Nancy Pelosi Institute to address democracy's challenges
Former House Speaker Nancy Pelosi and the University of California, Berkeley, are partnering to form a new nonpartisan academic institute they say will be dedicated to strengthening democracy.
Central College to offer data science major this fall
Central College will offer a new data science major starting this fall, bringing together STEM, social sciences and humanities teaching.
KATALIN KARIKÓ
She was met with resistance, got demoted and eventually forced to leave academia – but Katalin Karikó never lost focus, doubling-down on her work to harness mRNA for new vaccines and therapies. Karikó’s Nobel Prize-awarded discovery enabled the development of effective vaccines against COVID-19, offering protection to millions of people.
Mental health medications can cause heat sensitivity
Some drugs can impair the body’s ability to cool itself and require extra self-care.
Why resisting Trump has galvanized Black Democrats as the midterms approach
High primary turnout among Black voters in the South has given some in the party hope for upset wins in the region.
Millions drop Obamacare health coverage after subsidies expire and costs rise
Health analysts say the drop in enrollment was likely related to the Jan. 1 expiration of federal subsidies, which caused a surge in plan costs that resulted in many people being unable to pay their premiums.
Los Angeles Venezuelans collect aid after deadly earthquake as business owner searches for missing parents
Full Arepas, on Seventh Street near Hill Street, is accepting donations through Tuesday for people affected by the deadly earthquakes that struck northern Venezuela last week. Owner Kelly Montano said her parents are missing near Caracas.
Van crashes into former Benson business
A minivan drove through the side of a vacant building in Benson early Sunday morning, according to police.
Minivan crashes into vacant Benson business
WOWT 6 News 10 p.m. Sunday newscast
Multiple sclerosis affects social life and work beyond physical health
Multiple sclerosis (MS) can have a substantial impact on many aspects of life beyond physical health, with 51% of people reporting that the disease affects their social life and 48% reporting that it affects their work, according to new research presented at the European Academy of Neurology (EAN) Congress 2026.
Baker Mayfield Drops Clear Message on Kyler Murray
As Kyler Murray seeks a fresh start in Minnesota, former teammate Baker Mayfield defends the polarizing quarterback, predicting a dominant resurgence fueled by a much-needed change of scenery.
Millions drop Obamacare health coverage after subsidies expire and costs rise
Hampton Roads Virginia and Northeastern North Carolina News, Weather, Traffic and Sports.
New academic leader ready to get to business in Morgantown
New Provost Beverly Wendland officially begins her post July 1.
Fifty-Three Named To CSC Academic All-District® Women’s At-Large Team
MADISON, Wis.--Fifty-three Wisconsin Intercollegiate Athletic Conference (WIAC) individuals have been named to the 2025-26 NCAA Division III Academic All-District® Women’s At-Large Team, selected by the College Sports Communicators
Twenty-Four Named To CSC Academic All-District® Men’s At-Large Team
MADISON, Wis.--Twenty-four Wisconsin Intercollegiate Athletic Conference (WIAC) individuals have been named to the 2025-26 NCAA Division III Academic All-District® Men’s At-Large Team, selected by the College Sports Communicators
This Jibber-Jabber Night in Acadiana prohibits jibber jabber. Here's why it works.
Learn how Acadiana Talent in Lafayette provides a platform for musicians of all ages to perform, experiment and connect, contributing to the city's diverse music scene.
Raducanu 'plans to play' at Wimbledon despite injury setback
Emma Raducanu says she "plans to play" at Wimbledon despite a leg injury which has put her participation in serious doubt.
Algeria vs Austria Extended Highlights
Check out the full game highlights between Algeria and Austria in the 2026 FIFA World Cup™. Announced by JP Dellacamera and Lori Lindsey.
The Arts and Sciences of Judo: The New Edition Expands the Frontiers of Knowledge
The publication of Volume 6, Number 1 of "The Arts and Sciences of Judo" marks another important milestone in the development of judo research worldwide. As the International Judo Federation's interdisciplinary journal, under the supervision of Professor Sanda Čorak, it has become a recognised platform where science, education and the values of judo come together to deepen our understanding of the many dimensions of our sport. It also forms an integral part of the IJF Academy's mission to promote education, lifelong learning and the dissemination of knowledge throughout the global judo community.
Texas A&M’s Marcel Reed impresses in Air‑It‑Out exhibition
Marcel Reed delivered one of the top highlights at the Manning Passing Academy, dropping a perfect deep ball during the Air‑It‑Out exhibition.
While Isaac could still re-sign with Orlando, he will …
While Isaac could still re-sign with Orlando, he will …
Ann Blyth, Oscar nominee for 'Mildred Pierce,' dies at 98
LOS ANGELES — Ann Blyth, who was nominated for an Academy Award for playing the wicked, manipulative daughter in the 1945 noir melodrama "Mildred Pierce," has died at age 98.
3 million Americans have dropped Obamacare health coverage over past year, after Republicans let federal subsidies expire
KFF expects the total number of people in the government healthcare program to continue to decline throughout the year, potentially to a low of about 17.5 million from 19.2 million now.
Millions drop Obamacare health coverage after subsidies expire and costs rise
NEW YORK — About 3 million fewer people in the United States had Affordable Care Act health insurance plans in February compared with the same time...
Millions drop Obamacare health coverage after subsidies expire and costs rise
About 3 million fewer people in the United States had Affordable Care Act health insurance plans in February compared with the same time last year, according to new federal data. In the report releas...
Millions drop Obamacare health plans after subsidies expire and costs rise
New federal figures show that about 3 million fewer people had Affordable Care Act health insurance plans in February compared with the same time last year.
Millions drop Obamacare health coverage after subsidies expire and costs rise
New federal figures show that about 3 million fewer people had Affordable Care Act health insurance plans in February compared with the same time last year. The Department of Health and Human Services...
Millions drop Obamacare coverage after subsidies expire, costs rise
New federal figures show that about 3 million fewer people had Affordable Care Act health insurance plans in February compared with the same time last year
Five Million Americans Lost ACA Health Insurance—Here’s What That Could Mean For Public Health
New data shows 5 million Americans have lost health insurance through the ACA. A doctor breaks down the downstream consequences for public health in America.
5 million have dropped ACA insurance after Trump and the GOP let prices skyrocket
The number of people who signed up for a health plan and then didn't pay their premium fell much more sharply than it has in years past. Trump officials blame fraud. Health policy experts blame costs.
Raptor discovery in Argentina points to prehistoric links with China
Unearthed on opposite sides of the world, fossils of Kank australis and velociraptors sport matching claws, revealing evolutionary ties.
Arts & Entertainment Calendar
Events coming up in the Greenville area offer music, arts, theater and family fun. Here is a sampling.
Why Kemba Walker is excited about Hornets’ future, 2026 NBA Draft additions
Charlotte’s player enhancement coach spoke to The Charlotte Observer during grand opening of The Kemba Walker Sports Academy in Concord.
Could the Vikings eventually be forced to trade Justin Jefferson?
Is there a scenario where the Minnesota Vikings are forced to trade Justin Jefferson?
Healthcare AI Leaders Are Rapidly Trying To Outmaneuver Skyrocketing Memory And GPU Costs
Compute power has become one of the most crucial components of the healthcare delivery cycle.
EAST TEXAS POLITICS: Railroad commissioner, ag commissioner candidate clash on data centers
Texas Railroad Commissioner Wayne Christian, a Republican, and Democratic nominee for Texas Agriculture Commissioner Clayton Tucker, who hold opposing views on data centers, talked with Blake Holland for this week’s edition of East Texas Politics on East Texas Now. .
Maryland health insurers want to raise premiums an average 13.7% for individual plans in 2027
Maryland health insurers want to raise premiums an average 13.7% for individual ACA plans in 2027
See inside Kemba Walker's new youth sports hub
The former Charlotte Hornets star says the academy is about creating opportunities for the next generation of athletes.
Sports Intelligence Project explores high-end decision making in multifaceted industry
A new co-curricular offering tasks students with combining data, AI and the human element of athletics.
Meet Lara Pires, Valedictorian at Community Academy of Science and Health
Meet Lara Pires, Valedictorian at Community Academy of Science and Health
Civility advocates look for ways to restore 'Iowa Nice' to campaigns, public discourse
A group of former and current officeholders are looking to encourage civility by encouraging civic participation and civil interactions.
Texas A&M horticultural sciences students, faculty earn national recognition
Students and faculty within the Texas A&M Department of Horticultural Sciences received national awards for research, outreach and academics.
Music Legend Axes Shows After Onstage Health Scare
Lionel Richie was hospitalized on the opening night of his tour with Earth, Wind & Fire after feeling dizzy on-stage.
Business Owners Agree: The Road to Downtown Recovery Runs Through Facts, Not Nostalgia
State Street's commercial vacancy rate is lower today than it was before the pandemic. The highest vacancy rates remain on blocks that are open to vehicle traffic.
Samsung will soon start charging to access its smart home API
Regular users could get caught by Samsung’s new $4.99 monthly charge for individual developers.
Most Patients Want Docs To Break Cancer News Directly, Not Through Portal Messaging
By Dennis Thompson HealthDay ReporterFRIDAY, June 25, 2026 (HealthDay News) — People are becoming more comfortable communicating with their doctor through clinics’ patient portals. Folks use the portals to ask their doc questions and even to review the results of recent medical tests. But there are ...
Commitment season looming as Ohio State staff awaits
The month of June has been a grind for Ohio State’s coaching staff. Position camps, recruiting visits, and still prioritizing their current roster, the Buckeyes have had zero time off… and that will soon change. Ryan Day and company set to be on vacation in the coming days for a well deserved break, that doesn’t […]
TravelTech Show, Business Travel Show Europe name 2026 innovation award winners
Arcube, ImpersonAlly, Acai and Nowadays were recognized in separate competitions for travel technology innovations spanning airline retailing, brand protection, contact center automation and meetings management.
Monkey Business: Wild rhesus macaque spotted at Mount Dora hotel
A wild rhesus macaque was spotted at the historic Lakeside Inn in Mount Dora, Florida, spending about 45 minutes roaming the property and attracting attention from guests and staff. The hotel and local businesses responded with humorous, monkey-themed social media content, engaging the community. Wildlife officials cautioned the public not to approach or feed wild monkeys due to potential health risks and encouraged reporting sightings to authorities. The monkey has not returned to the hotel but has been seen elsewhere in downtown Mount Dora.
UT Health San Antonio researcher receives $400,000 Komen grant to study therapeutic yoga for breast cancer survivors
Amelie G. Ramirez, DrPH, MPH, to work with Hispanics in South Texas Contact: Steven Lee, (210) 450-3823, lees22@uthscsa.edu Content provided by Cliff Despres SAN ANTONIO, June 25, 2026 – Amelie G. Ramirez, DrPH, MPH, a cancer researcher at UT Health San Antonio, the academic health center of The University of Texas at San Antonio, is […]
PAHO mobilizes emergency health response following earthquakes in Venezuela
Caracas, Venezuela/Washington, D.C., 25 June 2026 (PAHO) – The Pan American Health Organization (PAHO) has activated its emergency response mechanisms to support the health response in Venezuela following two magnitude 7.5 earthquakes that struck the country on June 24.
Making Our Own Luck
We are cross-posting a piece that former NIH official Kris Willis wrote for Macroscience. Kris is now the President and Founder of the Woodley Park Institute, for which I’m a board member. Picking winners or hedging bets? Federal science agencies have long wrestled with the question of how to ensure their billions of dollars of grants and contracts result in maximum benefits for Americans. On the surface, it might seem that a goal-oriented, interventionist style of management would be the best policy: prioritize our most pressing problems and distribute funding accordingly.This top-down strategy creates a unique hazard, though: bad choices can send resources in the wrong direction, resulting in slow progress that impedes the delivery of tangible benefits to citizens. Moreover, if decision makers pursue an applied advance when the underlying scientific principles remain poorly understood, they risk costly failures and a loss of support for the research enterprise at large. Examples include Nixon’s 1971 War on Cancer, undertaken on the premise that a cure could be achieved in less than a decade, the drive to build an operational commercial fusion plant by the mid-1990s, and the National Plan to Address Alzheimer’s Disease, which failed to produce the effective treatments and prevention strategies promised by 2025. The contrasting laissez-faire approach is to hedge your bets. If the path to an advance is impossible to predict, then the wisest choice might be to distribute funding to as widely as possible. The main risk of this strategy is that spreading funding thinly may limit the resources available to the most promising research, resulting in the same negative outcomes as the interventionist approach: limited support for the most promising topics, slow progress, and delayed returns. In reality, at science agencies like the National Science Foundation and National Institutes of Health, program managers navigate between these two extremes, setting some funds aside to target high-priority areas and using the rest to cover the widest possible range of meritorious proposals. This middle path seems like the most rational way to proceed, but it still requires making choices. How much should be set aside for high priority topics? What should those topics be? How should we define merit? Expert opinion can provide a helpful guide, but leading experts can have remarkably different opinions about what matters and what should be prioritized. Moreover, experts and administrators alike can be risk averse, giving an edge to high-profile, well-established concepts. What’s really needed is a data-driven framework to help guide decision-making, one that doesn’t simply repackage prestige or incumbency. Recognizing breakthroughs years in advance Many breakthroughs fail to attract funding or recognition at the earliest stages of development. Katalin Karikó, for example, spent years struggling to win grants for work on mRNA that would eventually win her and Drew Weissman a Nobel Prize. Similar stories can be told about Jim Allison’s groundbreaking studies leading to the development of cancer immunotherapy, Stan Pruisner’s demonstration that prions can self-replicate without DNA, or Robin Warren and Barry Marshall’s proof that Helicobacter pylori, not stress, causes ulcers. Yet at some point, the scientific community recognizes and responds to transformative breakthroughs like these. How does that change happen? And what if science funders could identify the areas that are on the cusp of a breakthrough? Those questions led my collaborators and me to study how scientists responded to past breakthroughs. Based on patterns in that data, we developed a means of predicting future breakthroughs, using biomedicine as a proof of concept. It’s worth taking a moment to describe how our approach works. Briefly, our prediction process begins by grouping the 18 million or so peer-reviewed papers in PubMed, the authoritative database of biomedical research, into roughly 50,000 unique topics. A small subset of these topics are so widely acclaimed as breakthroughs that they have been recognized with a major prize like a Nobel or a Lasker Award. We theorized that studying the development of these outliers over time, especially before they gained acclaim, was the key to identifying future instances of them. After defining topics, we chose 21 representative breakthroughs and asked what they looked like before they won prestigious prizes. To answer that question, we re-ran our topic-mapping algorithm repeatedly, winding back the clock one year each time, stringing together the years to follow the progress of each field as it grew and advanced. We found that in each case, the years leading up to a discovery followed a pattern: a burst of papers on a new, rapidly evolving topic, many of which quickly became influential. These characteristics—the percent of papers that are new, the percentage of papers that are brought in from other topics, and the influence of each individual paper—can all be measured separately for any given topic. Together, they act as a predictive signal that is detectable an average of five years before a transformative discovery is made, and up to thirty years before the discovery receives a major prize. Scanning the current research landscape for topics that display this signal allows us to predict what work will likely produce a future breakthrough. Each year we analyzed includes four or five signals, a number that appears to have remained constant across a twenty year time frame. In their classic work on the sociology of science, Bruno Latour and Steve Woolgar established that the desire to participate in a major discovery is an important motivator for scientists as they consider whether they should take up (or abandon) a research problem. Although further work is needed, the simplest explanation for our results is that this behavior is widespread enough to detect at scale. A foundational advance, or something like it, draws the attention of scientists and causes them to change the direction of their research. They vote with their feet, staking their own reputation and careers by publishing on and citing the new idea. That upswell of interest is the foundation of our breakthrough signal. What kind of research does our model identify as a breakthrough? After building a model based on the patterns in our 21 preselected breakthroughs, we tested it by identifying all early signals of discovery from 1994 through 1997. Of the 18 signals we found in that time period, 17 can be traced forward in time to a breakthrough. Examples include super-resolution fluorescence microscopy (see the image above), the directed evolution of proteins and enzymes (Chemistry Nobel, 2018), and sequencing the human genome (National Medal of Science, 2008). The discovery of the role of leptin signaling in obesity is a particularly interesting case study. Around 1950, scientists noticed the existence of a type of lab mouse that suffered from a unique inherited form of obesity. When given the freedom to choose their own diet, these mice ate more than normal and preferred food that was high in fat. Researchers had few clues as to why the animals overate; early experiments pointed to the existence of a soluble ob factor found circulating in the bloodstream that regulated appetite, but its identity was unknown. In 1994, Jeffrey Friedman and colleagues identified and sequenced the ob gene, noting that the protein it encoded appeared to fit the profile of a circulating factor. A year later, a trio of high-profile publications demonstrated that ob was a hormone that regulated body weight and fat deposition by regulating appetite. One of these was co-authored by Friedman, who christened it leptin from the ancient Greek word for thin. Using our model, the data from 1996 make it clear this advance would become a breakthrough. Scientists had flocked to study the biology of the new hormone, generating the flurry of new papers and citations required to produce a signal. One of these demonstrated that serum leptin concentrations reflected the amount of adipose tissue in the human body, providing clinical validation of the earlier mouse studies. Before the identification of leptin, scientists were unable to point to a specific molecule that controlled appetite and adiposity, so that it was impossible to rule out non-physiological causes of obesity; its characterization fundamentally changed our concept of weight gain. In 2010, Friedman and fellow pioneer Douglas Coleman were awarded a Lasker for the discovery. Our work also identifies breakthroughs in clinical practice and behavioral and social sciences, even though these areas are less likely to draw the attention of major prize committees. One example that falls into this category is the introduction of endovascular aneurysm repair, a minimally invasive surgical procedure for the treatment of abdominal aortic aneurysm, a leading cause of death among Americans over the age of 65. Relative to the previous standard of care, it reduces in-hospital mortality by almost four-fold. In 2017, Timothy Chuter received the American College of Surgeons’ prestigious Jacobsen Innovation award for his multiple refinements to the technique. Another under-recognized breakthrough identified by our model is the development of standardized survey instruments to assess the quality of life for HIV+ patients. The antiretroviral cocktails introduced in the mid-1990s reduced AIDS mortality, but treatment came with serious side effects. The new evaluations showed that patients whose disease progressed had worse physical functioning than Americans with other chronic diseases, while those who were asymptomatic maintained a health-related quality of life on par with the overall US population. This evidence made it possible for patients and activists to argue that even in the absence of a total cure, and in spite of the side effects, alleviation of symptoms was a worthwhile priority for clinicians. My colleagues and I have failed to identify any significant recognition for the physicians and health policy experts who pioneered this advance, although in 2016, researchers called for the World Health Organization to set targets for good health-related quality of life as part of its framework to end the AIDS pandemic. From forecasting to funding How should science funders use our predictions? Any serious discussion of what we should do with this new capability needs to begin with an understanding of its limitations. We can’t (and shouldn’t) invest all of our resources in the small number of topics predicted to produce breakthroughs. Innovative new fields are born from existing ones; they rarely arise de novo. If funders don’t maintain a diverse portfolio, the breakthroughs of tomorrow will have no antecedents. Think of this as eating the seed corn, or killing the goose that lays the golden egg. There are also multiple goals of funding beyond basic scientific discovery, including translating discoveries into clinical practice, developing new technologies, supporting economic development, and training new scientists. The investments needed to accomplish these goals are likely different from those required to support emerging breakthroughs. Finally, we must be aware that we may not capture every instance of a breakthrough. The concept is fuzzy, and not every significant discovery is recognized with a major award. Further, breakthroughs are rare, meaning that our dataset is, by necessity, small. This makes formal estimates of accuracy challenging. Although our overall success rate appears to be high, any one signal may turn out to be a false positive. We found one apparent example: the development of the third generation COX-2 inhibitors, Vioxx and Celebrex, which were much celebrated in the early 2000s as effective but non-addictive pain relievers, meets all the algorithmic criteria of a breakthrough. Five years after it received FDA approval, researchers demonstrated that Vioxx was associated with serious cardiovascular complications, and the manufacturer voluntarily pulled the drug from the market. Celebrex remains available, although like other NSAIDs, it carries an FDA warning for increased cardiovascular risk. Decision makers who were overly focused on the breakthrough potential of this research might have wasted substantial resources nurturing an area that ultimately proved to be a failure—but so would those who relied on expert opinion at the time. That said, the potential benefits of funding the next mRNA vaccine or cancer immunotherapy years earlier than we might have are large. When we can’t assume the outcome of an action, it’s worth conducting an experiment. Can targeted support for areas that are poised to produce a breakthrough increase the return on scientific investment without cannibalizing future advances? With the necessary administrative infrastructure in place, conducting this experiment would be straightforward. First, identify all the breakthrough signals between 2018 and 2023, select half at random, and commit to a decade of investment. For biomedicine, a six year window should yield about 30 topics with the potential to produce a breakthrough. Providing strong support to half of these might be accomplished for $300 million a year. That’s roughly half of the recent annual budget of the NIH Common Fund or around 20% of the fiscal year 2025 budget for ARPA-H. After five years, then again at ten, compare to see which group — the one that was actively managed, or the control — produced more breakthroughs, and on what timescale. Although we used biomedicine as an example, the same experiment could just as well be run for physics, materials science, or any other discipline. Any attempt to undertake such an experiment should keep three points top of mind. First, we can predict the topic of future breakthroughs, but the people and vision for how to move the work forward are still important. In practice, this means success requires active program managers with the expertise to develop the science and the authority to do so, including by recruiting investigators. Second, we would be wise to learn from the failures of past attempts to fund transformative research. High among these are funding modestly repackaged work, confusing the genuinely novel with the merely unfamiliar, and relying too much on incumbent investigators. All of these risks can be mitigated by thoroughly and intelligently integrating high quality data into portfolio management. Finally, we need to have patience. Even with strong funding support, producing a breakthrough takes time. If supporting breakthroughs is the best way to nurture the birth of new fields, we also need to accurately describe and properly manage the other two stages, so that we invest wisely throughout the productive lifetime of ideas and divest once they reach the point of diminishing returns. We would benefit from more study of all of these phases, especially the transition from one to another. More research could answer questions like: When does a breakthrough become an established field? How do the availability of funding, the size and characteristics of the available workforce, and the accumulation of evidence that disagrees with prevailing models affect a field’s decline? Exactly how do old ideas give birth to new ones, and can we speed up the process? The more we understand about the dynamics of scientific progress, the better we can maximize the odds that our curiosity leads to results. I’d call that finding a way to make our own luck.
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Contact: Steven Lee, (210) 450-3823, lees22@uthscsa.edu Content provided by Claire Kowalick SAN ANTONIO, June 25, 2026 – Scientists at UT Health San Antonio, the academic health center of The University of Texas at San Antonio, found a link between a bacterium in the gut microbiome, or ecosystem, and lupus, which could lead to more effective […]
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