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Dario Announces Strategic Collaboration with Beluga Health to Deliver Provider-Backed, Integrated Care at Scale
/PRNewswire/ -- DarioHealth Corp. (NASDAQ: DRIO) (the "Company", "DarioHealth" or "Dario"), a leader in AI-powered digital health solutions, today announced it...
Dario Announces Strategic Collaboration with Beluga Health to Deliver Provider-Backed, Integrated Care at Scale
/PRNewswire/ -- DarioHealth Corp. (NASDAQ: DRIO) (the "Company", "DarioHealth" or "Dario"), a leader in AI-powered digital health solutions, today announced it...
Potential Xbox Series X|S owners: You should probably upgrade this July
With warnings of further price hikes coming for the video game console market, potential Xbox Series X|S owners might want to upgrade in July 2026.
Insider Sale: CEO of Business Group of $BABA Sells 13,579 Shares
Fan (FJ) Jiang, the CEO of Business Group of $BABA, sold 13,579 shares of the company on 06-25-2026 for an estimated $164,305. We received data on the trade from a recent SEC filing. This was a sale of approximately 2.4% of their shares of this class of stock. Following this trade, they now own 556,617 shares of this class of $BABA stock.$BABA Insider Trading Activity$BABA insiders have traded $BABA stock on the open market 7 times in the past 6
Comcast to split cable business from media through NBCUniversal, Sky spinoff
Comcast will split into two publicly traded companies through a spinoff of NBCUniversal and Sky, separating its cash-generating broadband arm from a media and entertainment business under pressure from streaming rivals and industry consolidation. The latest U.S. media industry shake-up follows years of cord-cutting as legacy players chase scale to better compete with Netflix while Paramount Skydance's $110 billion deal for Warner Bros Discovery is set to boost competition. Comcast, which leans on cable for much of its cash flow, is also losing broadband customers to fixed wireless offerings from T-Mobile and Verizon and to fiber rivals building out networks.
Patriotic movies to stream to celebrate America's 250th birthday
Patriotism on screen comes in all different forms. It's politicians, athletes, soldiers, pilots, journalists — people from all walks of life, coming together in ordinary and extraordinary ways and making
New look, same sole: Charm City Run founder keeps Baltimore moving
In Good Company: Josh Levinson made Charm City Run specifically for Baltimore. For nearly 25 years, the region has loved the business back.
It’s Linux, On A Sega Megadrive
If you were in the market for a games console in 1990, the chances are that the object of your desire was either a Super Nintendo with its 16-bit 6502 derivative, or the Sega Megadrive, sold as the…
Ingredion plans global Benicaros prebiotic expansion across gut and immune health applications
Ingredion highlights that its recent acquisition of the Benicaros prebiotic is a strong strategic addition to its Healthful Solutions portfolio, supporting the company’s formulation versatility alongside expansion of health-forward and clean label ingredients. The company purchased the patented prebiotic fiber, made from upcycled carrot pomace, from NutriLeads earlier this month. With the deal, Ingredion obtained full ownership of all intellectual property, trademarks, human clinical trials, and know-how related to manufacturing Benicaros.
Grand Theft Auto VI Rumored to Offer 60 FPS Mode on PS5/Xbox Series X, But Maybe Not at Launch
One of the reasons Grand Theft Auto VI fans are eager to learn the currently missing details on PS5 Pro enhancements is that the most powerful console available on the market is expected to include a performance mode targeting 60 FPS. However, according to a credible source, there's a decent chance that even the base PlayStation 5 and Microsoft's roughly equivalent Xbox Series X will support 60 FPS in Rockstar's massively anticipated game. The rumor comes from the popular Polish gaming podcast Rock and Borys, which features Remigiusz "Rock" Maciaszek and Borys Nieśpielak. It is the latter who shared in […]
FIFA Let Politics Win Over Football, Iran Paid The Price For Political Hypocrisy
Football's governing body has long sold itself as apolitical - like the IOC - an organisation above borders, above diplomacy, above conflict. But this World Cup has challenged that idea and changed perceptions about FIFA.
The last, best hope for the Colorado GOP
If the Colorado Republican Party desires to retain any relevancy, let alone wrest back any of the levers of political control in the state, it needs to elect Barb Kirkmeyer in the June 30 primary. To be sure, Kirkmeyer would be a solid candidate for governor in any case, whether or not she shared the […]
PS6 Hardware Cost Estimated at $900+
The upcoming Sony PlayStation 6 is slated to launch sometime in 2028, and with recent reports claiming that the ongoing RAM crisis likely won't end or ease up much before then, concerns are mounting about the price of next-gen gaming consoles. Those concerns are seemingly justified, with ubiquitous ...
VSP Vision Announces Winner of Propel Student Business Challenge Scholarship
RANCHO CORDOVA, Calif.—VSP Vision, in collaboration with the Student Optometric Leadership Network (SOLN), today announced that Mason Martin, a student at the University of Alabama at Birmingham School of Optometry, is the winner of the 2026 Propel Student Business Challenge Scholarship, powered by PECAA. Martin, who was awarded the $10,000 scholarship and a travel grant to attend the SOLN conference in Denver, is the first first-year student at the school to receive this honor, the announcement said. VSP said his standout submission featured a thoughtful, patient-centered private practice business plan.
I grew up in China, but I'm raising my daughter in LA. A trip back to visit family made me rethink my parenting style.
Philippines leads the world in rush to solar as power prices soar
People in the Philippines are flocking to install solar power on rooftops and escape the burden of soaring electricity prices, making it the world's biggest spender on solar panels since the war in Iran started.
OUTAGE RESOLVED: Tri-County mental health crisis lines back online
Update: As of Sunday, June 28 at 3:25 p.m., the Multnomah County Crisis Line, the Washington County Crisis Line and the Clackamas County Crisis and Support Line are currently back online.
Kadyn Proctor Can Solidify Dolphins Offensive Line in Big Way
The Miami Dolphins' offensive line may be good, but it can reach a strong height if rookie Kadyn Proctor can live up to expectations.
Atlanta businesses push back on proposed liquor license pause as leaders seek to curb Edgewood Avenue violence
Edgewood Avenue business owners back public safety improvements after recent violence, but some say pausing new liquor licenses won't solve crime's root causes.
Why Rock Ya-Sin Is Poised to Replace Terrion Arnold
No matter what happens in court, the Lions have a major problem to solve—and Rock Ya-Sin may be the biggest beneficiary.
Indian Health Center’s grief vigil offers space for remembrance
Gerald L. Ignace Indian Health Center gathers local Indigenous community to find solace in remembrance and grief.
Efzimfotase alfa demonstrated improvements in bone health in treatment-naïve pediatric patients with hypophosphatasia achieving median difference of 1.67 vs placebo in RGI-C Score at week 25 in MULBERRY Phase III trial
Positive results from the MULBERRY Phase III trial showed that efzimfotase alfa (ALXN1850), an investigational enzyme replacement therapy, demonstrated a statistically significant and clinically meaningful improvement in bone health in children (2 to
Major PS5 Feature Down for the Last 2 Weeks, Sony Silent
A widely used PS5 feature has been down for the last two weeks on both the console and the PS App, and there's no sign of a fix.
The PlayStation 6 Reportedly Already Costs $960 in Materials to Manufacture
The PlayStation 6 reportedly costs $960 to build in materials, suggesting next-gen consoles' prices could be much higher than anticipated.
Prescott, Parker present Cowboys with an 'iron sharpens iron' dynamic
Cowboys quarterback Dak Prescott has had issues solving two defensive schemes. With Christian Parker in the building, he may finally figure it out.
Xbox One gets a rare busy month with 12 noteworthy games coming July 2026
Microsoft's Xbox One consoles will enjoy a surprisingly busy month for new releases in July 2026, with 12 noteworthy games confirmed.
Progressives look to Colorado as next test of a rising movement
Melat Kiros, a 29-year-old democratic socialist and lawyer, is challenging 15-term Rep. Diana DeGette for a solidly blue seat in Denver, where she and her allies hope voters are ready for change.
Tariffs continue to add uncertainty to business climate: Top Workplaces 2026
Companies like Gardiner HVAC in Solon are navigating fluctuating prices and supply chain disruptions as tariff policy remains volatile more than a year after implementation.
GM hires talent from rivals to solve self-driving car problem
GM has made several key executive hires since 2025 and brought back Cruise alums to ramp up its self-driving tech development in personal cars.
Belkin launches new 14-in-1 Thunderbolt 5 dock with 140W charging and triple 4K display support
Belkin has launched a 14-in-1 Thunderbolt 5 Dock in China priced at 2,299 yuan (approximately $338). The Belkin dock ships with a 180W adapter and 1m cable and delivers 140W USB Power Delivery over a single Thunderbolt 5 connection, with bandwidth scaling from 80Gbps to 120Gbps for high-resolution display use. Belkin briefly listed the dock on its global website at $350 before removing the page, hinting at a global launch.
Today's NYT Connections: Sports Edition Hints, Answers for June 28 #643
Here's today's Connections: Sports Edition answer and hints for groups. These clues will help you solve The New York Times' popular puzzle game, Connections: Sports Edition, every day.
Hunter Goodman smashes three home runs vs. Twins
Colorado Rockies designated hitter Hunter Goodman hit three long home runs against the Minnesota Twins on Saturday. Goodman crushed two no-doubters — solo shots in the first and third innings — in his first two at-bats against Twins starter Mike Paredes. Then, after grounding out in the fifth, Goodman came up with two runners on base and the Rockies leading 3-2 in the seventh.
Here's How Much A 2022 Cadillac CT4-V Blackwing Has Depreciated In 4 Years
Starting at $60,390 in 2022, the Cadillac CT4-V Blackwing did a solid job at fighting depreciation over the last four years, now trading in the low $50,000s.
AI Is Helping Small Businesses Get More Done, But It’s Far From The Only Productivity-Booster Helping Them Expand
Getting more done in less time is easier than ever for solopreneurs and small business owners, thanks to the ease of hiring contractors, using QR codes, touchless technology and other affordable methods.
Nintendo issues June 2026 backwards compatibility fixes for Switch games on Switch 2, full list
Another set of backwards compatibility fixes for Nintendo Switch games on Switch 2 are now available. There aren’t as many heavy hitters this time around, but it’s still a solid batch. Shovel Knight: Treasure Trove is the biggest name out of the bunch – previously, Nintendo said that players may encounter audio issues in some areas. The full list of...
TherapyGo Announces Milestone as AI-Powered Mental Health Platform Expands Access to Licensed Psychologists
BOCA RATON, Fla., June 27, 2026 (GLOBE NEWSWIRE) -- United Innovation Solutions LLC today announced a major growth milestone for TherapyGo, its ...
A Clover Health Director Sold Over 67,000 Company Shares. Here's a Closer Look at the Transaction.
This healthcare technology firm, focused on Medicare Advantage plans, reported a notable insider sale amid muted stock performance.
Star Wars Eclipse "literally cannot be finished" if layoffs go through, its devs reportedly say
"We absolutely need the 115 people who have been inactive (or almost) for a month already."
Ranked: America’s Best-Selling Albums Ever
Michael Jackson may be the king of pop, but in the U.S. he's been outsold by a rock band from Los Angeles.
What scientists discovered about coffee grounds will transform construction industry - Futura-Sciences
At the start of 2024, a study published several months ago is once again drawing attention. Scientists at RMIT University in Australia have identified an unexpected use for spent coffee grounds, opening the door to a promising solution for both the construction sector and organic waste management. From coffee waste...
"This doesn’t represent pre-order data," Xbox disputes reports of PS5 crushing GTA 6 preorder demand
As rumors of a massive sales gap circulate, Xbox sets the record straight on why affiliate clicks are not the same as console sales.
US Army commander used drones, C4-packed robots to clear breach
A recent drill saw dozens of drones targeting enemy weapons, sensors, and positions before soldiers attempted to approach.
CARE AT HOME GUARANTEE CORPORATION FILES PATENT APPLICATION FOR PROPRIETARY BUSINESS MANAGEMENT SYSTEM
Miami, FL, June 27, 2026 (GLOBE NEWSWIRE) -- CARE AT HOME GUARANTEE CORPORATION ('the Company'), a Florida-based Senior Care Solutions company, ...
Walker Buehler delivers statement win for the Padres over Dodgers
The Sporting Tribune's Fernando Ramirez writes about Walker Buehler throwing a solid game against his former team.
Scalpers List Steam Machine Reservations at $1,700+
Following a brief reservation period, prospective buyers of the Valve Steam Machine started reporting on June 26 that they had begun to receive reservation confirmation emails for the new hybrid console. However, on the same day, and almost predictably, apparent scalpers listed Steam Machine units o...
Consumer-Directed Health Care: Promise or Pitfall
This panel will examine the evidence and policy outlook for consumer-directed health care as a federal solution to expanded coverage, with a focus on affordability, access, and health outcomes.
Public health alert issued for chicken sold at popular grocery store in the Tri-State area
A public health alert was issued for chicken sold at a popular grocery store chain in the Tri-State area.
PlayStation hardware sales fall to their lowest May total since 2000
Price rises hit Sony's console sales, but 007 First Light and Switch 2 help US game spending to grow 3%
Epic's Tim Sweeney Keeps Inventing Solutions To Problems That Are Already Solved
Quick, someone tell him what Discord is
Master Inventor Hoffman Turns Chemistry Into Capability | Johns Hopkins University Applied Physics Laboratory
Christopher Hoffman has been recognized as a Johns Hopkins APL Master Inventor, a distinction earned through a career spent asking a simple question: What can chemistry can do to solve a real-world problem?
Medicare will soon offer some older Oregonians weight loss drugs for $50 a month. Here’s how it works.
Medicare has long excluded coverage of GLP-1s prescribed solely for weight loss.
NASA’s PACE Mission Studies Smoke, Fires
With the North American fire season underway, and a record number of acres already burned nationwide, NASA’s Plankton, Aerosol, Cloud, and ocean Ecosystem
How to Keep Your Skin Healthy and Hydrated in Summer Months
From sunburns to heat rashes, board-certified Dr. Angela Lamb joins TODAY with solutions for common summer skin problems.
Quiz of the week: how do scientists hope to protect Earth from dangerous solar storms?
Have you been keeping up to date with physics news? Try our short quiz to find out
Nintendo Switch 2 ends first full year in the U.S. at nearly 6 million units sold, second fastest-selling video game system
Following the latest U.S. sales report from Circana, we have information about the first full-year sales of Nintendo Switch 2. The console ended its first twelve months at 5.9 million units sold. According to Circana, it’s the second fastest-selling video game system in the U.S. with tracked history dating back to 1995. The only other platform to outdo it was...
Valve's HDMI 2.1 Saga Is "Fully Resolved" with a Final FRL Update to Come For Full 4K 240Hz support
My monitor is ready.
With GTA looming, consoles are getting expensive at the worst possible time
Vice City ain’t cheap.
PlayStation Boss Says New Console Experiences Will Involve 'Leveraging Technologies That Can Be Used in Various Forms and Locations' — and I'm Convinced He's Teasing a PS6 Handheld
Recent comments from Sony Interactive Entertainment CEO Hideaki Nishino have suggested PlayStation may move towards more hybrid, Switch-like consoles in the future to match modern on-the-go players.
NTT DATA | Transforming Data Into Exceptional Fan Experience
We worked with Penske Automotive Group to create a mobile application to amplify the fan experience and make the iconic Indianapolis Motor Speedway a smart venue through NTT Smart Solutions.
County Invites Youth, Camps To Register For ‘Mind Your Business’ July 7 - Town-Crier Newspaper
Palm Beach County’s Mind Your Business Youth Entrepreneurship Forum returns on July 7, offering a full day of hands-on learning and innovation for young people across the county. Now in its seventh year, the forum is designed to inspire the next generation of creators, problem-solvers and emerging business leaders. Open to youth ages 10 to […]
As Colorado votes, rural voter politics could influence key races
Rural doesn’t necessarily mean conservative, and the opinions of these 10 voters run the gamut.
It's Summer Sale Season, So I Tracked Down 25 Actually Good Gaming Deals Under $20
There's a million sales happening right now, so I sifted through them all to find 25 genuinely solid gaming deals that are each under $20.
It's Xbox's turn (again), as console prices keep going up
Microsoft announced a price hike for the Xbox Series consoles today, the third in little over a year. Effective August 1, the Xbox Series S, which launched in 2020 for $300, will cost $500 in the U.S. The Xbox Series X, which launched in 2020 at $500, will go for $800. This follows a round of PlayStation 5 price increases from Sony this spring, and a slow-motion increase for Nintendo’s Switch 2, which will kick in in the U.S. in September. (Mind you, there were also eight video game industry price hikes in six months of 2025). The chart up top shows the sudden ascent of console prices over the past year, a sudden surge in an already unusual hardware generation. Prices had been flat for years, now “up” is the new “flat.” Game console prices used to go down across the length of a console generation, but not this time around. Microsoft’s explanation for the new price hike today: We hoped another price increase would not be necessary, and we have spent the last several months working with suppliers on options. Unfortunately, console storage and memory prices have increased by more than 2.5x and we expect another doubling by the fall of 2027. The entire consumer electronics industry is struggling with the current components crisis, but the effects are particularly hard on consoles. Unlike phones, computers, speakers, and other consumer devices, consoles are typically not sold at a profit, but instead for less than they cost to make. This is an issue well beyond game consoles. Apple announced price hikes on its computers and tablets today as well. Game File is a reader-supported publication. To receive new posts and support my work, consider becoming a free or paid subscriber. Subscribe Item 2: Brutal Bungie cuts Bungie laid off “most” of its Destiny development team and some developers who worked on Marathon, the newest game from the struggling Sony-owned studio. A WARN notice issued by Sony to Washington State, where Bungie is based, tallied cuts impacting 292 workers, effective next month. That’s strictly for Bungie/Sony jobs in Washington and wouldn’t account for any elsewhere. The video I clipped below shows the redacted list of Bungie cuts filed to Washington State officials. As you’ll see, I had to scroll for a while… In a note emailed to PlayStation workers and published online, PlayStation game studios chief Hermen Hulst offered the following explanation for these latest cuts at Bungie: This is painful news, especially for talented colleagues whose roles have been eliminated. This decision was made only after extensive discussion and careful consideration, and I want to provide some context on how we arrived here. Over the past several months, together with Bungie leadership, we reviewed the studio’s long-term direction, development priorities, resource needs, and role within our broader portfolio strategy. We explored multiple alternatives before concluding that a reduction was necessary to align the studio’s resources with its current priorities and long-term goals. In 2022, Sony bought Bungie for $3.7 billion. The studio’s marquee game, the multiplayer live service shooter Destiny 2 was losing popularity at the time. Its next game Marathon, released earlier this year, has been well-reviewed but had a slow start. Bungie is renowned for making great shooter games, and Destiny fans have mourned the wind-down of Destiny 2. They’ve also expressed bewilderment over reports that Destiny 3 is not, per Bloomberg, immediately in the cards.
Vice President JD Vance talks faith and politics in Orange County
Vance largely talked about his grandmother’s influence at the sold-out event, which came on the heels of his new memoir, “Communion: Finding My Way Back to Faith.”
Mental health as both outcome and determinant in climate adaptation
Nature Climate Change - Mental health should not be viewed solely as a passive outcome of climate adaptation. Rather, it serves as a key determinant of cognitive capacity and shapes the...
Yearslong Resident Evil mystery solved: Kyle MacLachlan revealed to be Jill Valentine's 'boyfriend'
Twin Peaks star has ties to STARS
Brand New, Retail Boxed Nintendo Switch 2 Gaming Consoles Are Going for as Low as $399 for Amazon Prime Day
Brand new.
Making Our Own Luck
We are cross-posting a piece that former NIH official Kris Willis wrote for Macroscience. Kris is now the President and Founder of the Woodley Park Institute, for which I’m a board member. Picking winners or hedging bets? Federal science agencies have long wrestled with the question of how to ensure their billions of dollars of grants and contracts result in maximum benefits for Americans. On the surface, it might seem that a goal-oriented, interventionist style of management would be the best policy: prioritize our most pressing problems and distribute funding accordingly.This top-down strategy creates a unique hazard, though: bad choices can send resources in the wrong direction, resulting in slow progress that impedes the delivery of tangible benefits to citizens. Moreover, if decision makers pursue an applied advance when the underlying scientific principles remain poorly understood, they risk costly failures and a loss of support for the research enterprise at large. Examples include Nixon’s 1971 War on Cancer, undertaken on the premise that a cure could be achieved in less than a decade, the drive to build an operational commercial fusion plant by the mid-1990s, and the National Plan to Address Alzheimer’s Disease, which failed to produce the effective treatments and prevention strategies promised by 2025. The contrasting laissez-faire approach is to hedge your bets. If the path to an advance is impossible to predict, then the wisest choice might be to distribute funding to as widely as possible. The main risk of this strategy is that spreading funding thinly may limit the resources available to the most promising research, resulting in the same negative outcomes as the interventionist approach: limited support for the most promising topics, slow progress, and delayed returns. In reality, at science agencies like the National Science Foundation and National Institutes of Health, program managers navigate between these two extremes, setting some funds aside to target high-priority areas and using the rest to cover the widest possible range of meritorious proposals. This middle path seems like the most rational way to proceed, but it still requires making choices. How much should be set aside for high priority topics? What should those topics be? How should we define merit? Expert opinion can provide a helpful guide, but leading experts can have remarkably different opinions about what matters and what should be prioritized. Moreover, experts and administrators alike can be risk averse, giving an edge to high-profile, well-established concepts. What’s really needed is a data-driven framework to help guide decision-making, one that doesn’t simply repackage prestige or incumbency. Recognizing breakthroughs years in advance Many breakthroughs fail to attract funding or recognition at the earliest stages of development. Katalin Karikó, for example, spent years struggling to win grants for work on mRNA that would eventually win her and Drew Weissman a Nobel Prize. Similar stories can be told about Jim Allison’s groundbreaking studies leading to the development of cancer immunotherapy, Stan Pruisner’s demonstration that prions can self-replicate without DNA, or Robin Warren and Barry Marshall’s proof that Helicobacter pylori, not stress, causes ulcers. Yet at some point, the scientific community recognizes and responds to transformative breakthroughs like these. How does that change happen? And what if science funders could identify the areas that are on the cusp of a breakthrough? Those questions led my collaborators and me to study how scientists responded to past breakthroughs. Based on patterns in that data, we developed a means of predicting future breakthroughs, using biomedicine as a proof of concept. It’s worth taking a moment to describe how our approach works. Briefly, our prediction process begins by grouping the 18 million or so peer-reviewed papers in PubMed, the authoritative database of biomedical research, into roughly 50,000 unique topics. A small subset of these topics are so widely acclaimed as breakthroughs that they have been recognized with a major prize like a Nobel or a Lasker Award. We theorized that studying the development of these outliers over time, especially before they gained acclaim, was the key to identifying future instances of them. After defining topics, we chose 21 representative breakthroughs and asked what they looked like before they won prestigious prizes. To answer that question, we re-ran our topic-mapping algorithm repeatedly, winding back the clock one year each time, stringing together the years to follow the progress of each field as it grew and advanced. We found that in each case, the years leading up to a discovery followed a pattern: a burst of papers on a new, rapidly evolving topic, many of which quickly became influential. These characteristics—the percent of papers that are new, the percentage of papers that are brought in from other topics, and the influence of each individual paper—can all be measured separately for any given topic. Together, they act as a predictive signal that is detectable an average of five years before a transformative discovery is made, and up to thirty years before the discovery receives a major prize. Scanning the current research landscape for topics that display this signal allows us to predict what work will likely produce a future breakthrough. Each year we analyzed includes four or five signals, a number that appears to have remained constant across a twenty year time frame. In their classic work on the sociology of science, Bruno Latour and Steve Woolgar established that the desire to participate in a major discovery is an important motivator for scientists as they consider whether they should take up (or abandon) a research problem. Although further work is needed, the simplest explanation for our results is that this behavior is widespread enough to detect at scale. A foundational advance, or something like it, draws the attention of scientists and causes them to change the direction of their research. They vote with their feet, staking their own reputation and careers by publishing on and citing the new idea. That upswell of interest is the foundation of our breakthrough signal. What kind of research does our model identify as a breakthrough? After building a model based on the patterns in our 21 preselected breakthroughs, we tested it by identifying all early signals of discovery from 1994 through 1997. Of the 18 signals we found in that time period, 17 can be traced forward in time to a breakthrough. Examples include super-resolution fluorescence microscopy (see the image above), the directed evolution of proteins and enzymes (Chemistry Nobel, 2018), and sequencing the human genome (National Medal of Science, 2008). The discovery of the role of leptin signaling in obesity is a particularly interesting case study. Around 1950, scientists noticed the existence of a type of lab mouse that suffered from a unique inherited form of obesity. When given the freedom to choose their own diet, these mice ate more than normal and preferred food that was high in fat. Researchers had few clues as to why the animals overate; early experiments pointed to the existence of a soluble ob factor found circulating in the bloodstream that regulated appetite, but its identity was unknown. In 1994, Jeffrey Friedman and colleagues identified and sequenced the ob gene, noting that the protein it encoded appeared to fit the profile of a circulating factor. A year later, a trio of high-profile publications demonstrated that ob was a hormone that regulated body weight and fat deposition by regulating appetite. One of these was co-authored by Friedman, who christened it leptin from the ancient Greek word for thin. Using our model, the data from 1996 make it clear this advance would become a breakthrough. Scientists had flocked to study the biology of the new hormone, generating the flurry of new papers and citations required to produce a signal. One of these demonstrated that serum leptin concentrations reflected the amount of adipose tissue in the human body, providing clinical validation of the earlier mouse studies. Before the identification of leptin, scientists were unable to point to a specific molecule that controlled appetite and adiposity, so that it was impossible to rule out non-physiological causes of obesity; its characterization fundamentally changed our concept of weight gain. In 2010, Friedman and fellow pioneer Douglas Coleman were awarded a Lasker for the discovery. Our work also identifies breakthroughs in clinical practice and behavioral and social sciences, even though these areas are less likely to draw the attention of major prize committees. One example that falls into this category is the introduction of endovascular aneurysm repair, a minimally invasive surgical procedure for the treatment of abdominal aortic aneurysm, a leading cause of death among Americans over the age of 65. Relative to the previous standard of care, it reduces in-hospital mortality by almost four-fold. In 2017, Timothy Chuter received the American College of Surgeons’ prestigious Jacobsen Innovation award for his multiple refinements to the technique. Another under-recognized breakthrough identified by our model is the development of standardized survey instruments to assess the quality of life for HIV+ patients. The antiretroviral cocktails introduced in the mid-1990s reduced AIDS mortality, but treatment came with serious side effects. The new evaluations showed that patients whose disease progressed had worse physical functioning than Americans with other chronic diseases, while those who were asymptomatic maintained a health-related quality of life on par with the overall US population. This evidence made it possible for patients and activists to argue that even in the absence of a total cure, and in spite of the side effects, alleviation of symptoms was a worthwhile priority for clinicians. My colleagues and I have failed to identify any significant recognition for the physicians and health policy experts who pioneered this advance, although in 2016, researchers called for the World Health Organization to set targets for good health-related quality of life as part of its framework to end the AIDS pandemic. From forecasting to funding How should science funders use our predictions? Any serious discussion of what we should do with this new capability needs to begin with an understanding of its limitations. We can’t (and shouldn’t) invest all of our resources in the small number of topics predicted to produce breakthroughs. Innovative new fields are born from existing ones; they rarely arise de novo. If funders don’t maintain a diverse portfolio, the breakthroughs of tomorrow will have no antecedents. Think of this as eating the seed corn, or killing the goose that lays the golden egg. There are also multiple goals of funding beyond basic scientific discovery, including translating discoveries into clinical practice, developing new technologies, supporting economic development, and training new scientists. The investments needed to accomplish these goals are likely different from those required to support emerging breakthroughs. Finally, we must be aware that we may not capture every instance of a breakthrough. The concept is fuzzy, and not every significant discovery is recognized with a major award. Further, breakthroughs are rare, meaning that our dataset is, by necessity, small. This makes formal estimates of accuracy challenging. Although our overall success rate appears to be high, any one signal may turn out to be a false positive. We found one apparent example: the development of the third generation COX-2 inhibitors, Vioxx and Celebrex, which were much celebrated in the early 2000s as effective but non-addictive pain relievers, meets all the algorithmic criteria of a breakthrough. Five years after it received FDA approval, researchers demonstrated that Vioxx was associated with serious cardiovascular complications, and the manufacturer voluntarily pulled the drug from the market. Celebrex remains available, although like other NSAIDs, it carries an FDA warning for increased cardiovascular risk. Decision makers who were overly focused on the breakthrough potential of this research might have wasted substantial resources nurturing an area that ultimately proved to be a failure—but so would those who relied on expert opinion at the time. That said, the potential benefits of funding the next mRNA vaccine or cancer immunotherapy years earlier than we might have are large. When we can’t assume the outcome of an action, it’s worth conducting an experiment. Can targeted support for areas that are poised to produce a breakthrough increase the return on scientific investment without cannibalizing future advances? With the necessary administrative infrastructure in place, conducting this experiment would be straightforward. First, identify all the breakthrough signals between 2018 and 2023, select half at random, and commit to a decade of investment. For biomedicine, a six year window should yield about 30 topics with the potential to produce a breakthrough. Providing strong support to half of these might be accomplished for $300 million a year. That’s roughly half of the recent annual budget of the NIH Common Fund or around 20% of the fiscal year 2025 budget for ARPA-H. After five years, then again at ten, compare to see which group — the one that was actively managed, or the control — produced more breakthroughs, and on what timescale. Although we used biomedicine as an example, the same experiment could just as well be run for physics, materials science, or any other discipline. Any attempt to undertake such an experiment should keep three points top of mind. First, we can predict the topic of future breakthroughs, but the people and vision for how to move the work forward are still important. In practice, this means success requires active program managers with the expertise to develop the science and the authority to do so, including by recruiting investigators. Second, we would be wise to learn from the failures of past attempts to fund transformative research. High among these are funding modestly repackaged work, confusing the genuinely novel with the merely unfamiliar, and relying too much on incumbent investigators. All of these risks can be mitigated by thoroughly and intelligently integrating high quality data into portfolio management. Finally, we need to have patience. Even with strong funding support, producing a breakthrough takes time. If supporting breakthroughs is the best way to nurture the birth of new fields, we also need to accurately describe and properly manage the other two stages, so that we invest wisely throughout the productive lifetime of ideas and divest once they reach the point of diminishing returns. We would benefit from more study of all of these phases, especially the transition from one to another. More research could answer questions like: When does a breakthrough become an established field? How do the availability of funding, the size and characteristics of the available workforce, and the accumulation of evidence that disagrees with prevailing models affect a field’s decline? Exactly how do old ideas give birth to new ones, and can we speed up the process? The more we understand about the dynamics of scientific progress, the better we can maximize the odds that our curiosity leads to results. I’d call that finding a way to make our own luck.
Entrepreneurs pitched business ideas to Yahoo Finance
Yahoo Finance Executive Editor Brian Sozzi is on the hunt for the next big business breakthrough. Check out the absolute best pitches and standout moments from the innovators making waves at Cannes Lions.
NASA Selects Rocket Lab to Launch Sun, Earth Science Missions
NASA has selected Rocket Lab to provide the launch service for both the agency’s PolSIR (Polarized Submillimeter Ice-cloud Radiometer) and Total and Spectral Solar Irradiance Sensor-2 (TSIS-2) missions.
Bio-Techne, a Minneapolis life sciences firm with 500,000 products, to be sold to German company for $11.3 billion
Consumer Discretionary Stocks Drawing Institutional Rotation Into Live Entertainment Leaders
With the Federal Reserve hinting at a pause in rate hikes, stubborn inflation still in the background, and several large companies surprising on earnings, consumer discretionary stocks are back in focus for investors weighing risk and opportunity. This article looks at how that mix of easier policy signals, solid corporate reports, and ongoing geopolitical and supply chain issues could affect larger U.S. consumer-focused companies. It will walk through 3 stocks from a curated screener that...
Following Apple, Microsoft Dramatically Hikes Xbox Prices, Again
Just hours after Apple increased its hardware prices across the board, Microsoft is doing the same with its Xbox consoles. For the third time.
Microsoft lifts price of Xbox consoles due to soaring component costs
Microsoft said it's increasing the price of Xbox game consoles after Apple announced price hikes for MacBooks and iPads.
Updated XBOX Console Prices
Effective August 1, 2026, the price of XBOX consoles will be increasing by US$100 for 512 GB models and US$150 for 1 TB models.
Yes/Boston Announces Inaugural Cohort of 12 Innovators Advancing Food and Health Solutions
/PRNewswire/ -- Yes/Boston, an initiative intended to accelerate innovation at the intersection of food systems and health, today announced its inaugural...
Sony A7R VI review: A huge speed boost makes this a nearly perfect high-resolution camera
Sony’s A7R VI finally serves up speed and resolution together thanks to the new 67MP stacked sensor.
Another look at carrots and eyesight; how to get more fiber; why mosquitoes bite some people and not others; plus other stories with Vanderbilt Health sources
AARP reporter Stacey Colino interviewed Milam Brantley, MD, Associate Professor of Ophthalmology and Visual Sciences, in 2020 for a story about whether eating carrots can improve vision. Sacramento Bee reporter Samantha Agate has now used Brantley’s comments in an AI-curated story created by content specialists on the same topic that has been picked up by MSN and others. Prevention magazine interviewed Heidi Silver, RD, PhD, Founding Director of the Vanderbilt Diet, Body Composition, and Human Metabolism Core, for a story about the importance of fiber and how people can get more of it in their diet. William Schaffner, MD, Professor of Preventive Medicine, was quoted by several news outlets about public health issues, including: Women’s Health (tick bites and alpha-gal syndrome); The Washington Post (tetanus); and Healthline (why mosquitoes prefer to bite some people and leave others alone). A visit to Monroe Carell Jr. Children’s Hospital at Vanderbilt by some Banana Ball baseball players was covered by The Tennessean and WZTV Fox 17 News, and The Tennessean’s story was also picked up by Yahoo! Sports. Clarksville Now published a story written by the Montgomery County Economic Development Team, whointerviewed Bradley Stancombe, MD, professor of Clinical Pediatrics, Vanderbilt Neonatology, about the new energy of Vanderbilt Clarksville Hospital and how the facility is recruiting physicians. Healio Allergy/Asthma group editorial director Richard Gawel interviewed Mark Rolfsen, MD, Clinical Fellow in the Division of Allergy, Pulmonary and Critical Care Medicine, for a story about his presentation at the American Thoracic Society meeting on metal health outcomes following ICU discharge. Nashville Scene reporter Hannah Herner interviewed James Crowe, MD, Director of the Vanderbilt Center for Antibody Therapeutics, for a story about his efforts to prepare for the next pandemic by isolating antibodies that can neutralize dangerous viruses. Medscape reporter Kathleen Doheny interviewed Neesha Choma, Associate Chief of Staff of Vanderbilt University Hospital, for a story about how hospitals can reduce readmissions.
How Elifin is reshaping the commercial real estate playbook
Elifin is leveraging a decade's worth of proprietary commercial real estate data as well as artificial intelligence to reshape how properties are marketed, analyzed and sold. The Baton Rouge-based … Already an INSIDER? Sign in. Already an INSIDER? Sign in
Service & Solidarity Spotlight: Health Care Professionals in New Jersey Ratify New Contract
Members of United Food and Commercial Workers (UFCW) Local 152 who work at Cape Regional Physicians Associates (CRPA) in New Jersey have secured a powerful new collective bargaining agreement.
Samsung’s new budget phone costs $50 more despite downgrades
The Galaxy A27 has a new chip, but worse waterproofing and lower resolution cameras than its predecessor.
David P. O'Brien
About five years ago, David P. O'Brien had a comfortable position at Marsh & McLennan Cos., where he held the top post at the financial giant's Louisville, Ky., office. Despite the lofty rank, Mr. O'Brien found himself longing to be at a smaller company that had to work a little harder to land business. That desire led him away from Kentucky five years ago and to Cleveland, where he serves as executive vice president at business insurance agency Oswald Cos. "I left Marsh before it was en vogue," he said, referring to layoffs and defections at Marsh over the course of this year that followed accusations of bid rigging at the big firm. Above all, Mr. O'Brien, 38, wanted to work at a company that relied on its inventiveness, rather than its name, for business. He said he has found that at Oswald. "It causes you to be more creative, to be more resourceful," Mr. O'Brien said. For instance, an Oswald client seeking to do business internationally might be directed to the network of offices abroad run by competitors such as Marsh and Aon Risk Services Inc. "We're going to use whatever access into the market that makes the most sense for our clients," he said. Of course, using such a strategy can be dangerous for Oswald if its client decides to further a business relationship with one of the firms Oswald recommended. "That's the obvious question and why it's nontraditional," he said. "I think if we're good, and if we're bringing value to the client, then there's no risk. I'm not threatened by it." Imaginative business solutions of that type made his career move to Oswald from Marsh worthwhile. "It's very much a challenge," he said. "It helps you keep your edge. I'm all for the competition." John Jacunski, currently vice president and corporate controller at York, Pa., paper company PH Gladfelter Co., met Mr. O'Brien four years ago when Mr. Jacunski was at WCI Steel Inc. in Warren. So impressed was he with Mr. O'Brien's work for WCI that Mr. Jacunski has retained the Oswald executive at PH Gladfelter. "He's a young guy for the position he has, but he's done a great job for us," Mr. Jacunski said. Among his roles at Oswald, Mr. O'Brien leads the firm's client retention efforts and also serves as director of its property and casualty group. "You don't have the same human resources," he said of the job jump to Oswald. "You don't have, obviously, the safety net a big company has." But sometimes, it can be difficult to ascertain individual contributions when working at a big company. "I wanted to be able to see the end results of my work and my efforts," Mr. O'Brien said.
Apolosign Digital Calendar and Portable TV for Family Organization and Home Entertainment
NEW YORK, June 25, 2026 (GLOBE NEWSWIRE) -- Apolosign, a smart family display brand serving more than one million households worldwide, today an...
Scientists discover how a single cell builds a brain with 170 billion cells
How does a single cell build a brain with billions of precisely organized neurons? Researchers suggest that brain cells use their lineage—their cellular family tree—as a kind of positional map. Cells that come from the same ancestor stay near one another, helping the brain organize itself without relying solely on chemical signals.
Kustom Entertainment Announces $5.5 Million Divestiture of Legacy Video Solutions Division to Cycurion, Advancing Live Entertainment Focus
Kustom Entertainment announces divestiture of video solutions division to Cycurion, enhancing focus on live events and ticketing.Quiver AI SummaryKustom Entertainment, Inc. announced a binding agreement to sell its legacy video solutions division to Cycurion, Inc., in a deal worth up to $5.5 million, including $1.25 million in cash and a $4.25 million promissory note. The transaction, expected to close in July 2026, will provide Kustom with finan
KUSTOM ENTERTAINMENT, INC. ANNOUNCES BINDING AGREEMENT FOR THE DIVESTITURE OF ITS VIDEO SOLUTIONS SEGMENT TO FULLY COMPLETE LIVE ENTERTAINMENT PIVOT
Transaction Structured to Provide Up to $5.5 Million plus 2,000,000 Warrants to acquire shares of common stock of Cycurion, Inc.; Follows Previously Announced Major Live Music Expansion Partnership with Gilley’s Park City OVERLAND PARK, KS, June 25, 2026 (GLOBE NEWSWIRE) -- Kustom Entertainment, Inc. (Nasdaq: KUST) (the “Company”), a live entertainment and music festival company, today announced it has entered into a binding agreement for the divestiture of its legacy video solutions division to
KUSTOM ENTERTAINMENT, INC. ANNOUNCES BINDING AGREEMENT FOR THE DIVESTITURE OF ITS VIDEO SOLUTIONS SEGMENT TO FULLY COMPLETE LIVE ENTERTAINMENT PIVOT
Transaction Structured to Provide Up to $5.5 Million plus 2,000,000 Warrants to acquire shares of common stock of Cycurion, Inc.; Follows Previously...
Senate Republicans reject war powers resolution after Trump-Cassidy clash
The late-night vote came hours after a fractious meeting that included a shouting match with President Donald Trump over some senators’ opposition to the conflict.
America’s Friendship Recession Has Become a Startup Opportunity
A new “connection economy” is selling courses, clubs and confidence bootcamps to socially isolated adults, but scaling intimacy remains a challenge.
Under pressure from Trump, Republican-led Senate reverses course on Iran
The chamber rejected a resolution to force Trump to end the war after he criticized Republicans for undermining his administration’s negotiations.
Senate walks back rebuke of Trump over Iran war
One day after adopting a resolution aimed at removing US military forces from the conflict with Iran, the Senate walked back its rebuke of President Donald Trump’s handling of the war, rejecting an attempt to advance a similar war powers measure.
Senate walks back rebuke of Trump over Iran war
One day after adopting a resolution aimed at removing US military forces from the conflict with Iran, the Senate walked back its rebuke of President Donald Trump’s handling of the war, rejecting an attempt to advance a similar war powers measure.
Closed-door outburst turns into victory for Trump’s Iran negotiations
Senate Republicans flipped to reject Democrats' Iran war powers resolution, handing Trump a key win as U.S.-Iran peace deal talks continue on.
“Absolutely huge” 400-year-old black coral stuns scientists in New Zealand
A giant black coral estimated to be 300–400 years old has been discovered deep in Fiordland, New Zealand, astonishing researchers with its enormous size—about 4 meters tall and 4.5 meters wide. Scientists say it may be one of the largest black corals ever recorded in New Zealand waters and an important stronghold for the slow-growing species.
'Stone Crazy' Millwood business owner entices neighbors outdoors with crystal searches
Nowadays, the sole proprietor of Millwood’s Stone Crazy crystal shop is enticing today’s youth to follow in her outdoorsy footsteps— quite literally. Since the pandemic, Jenny Dykes has been leaving crystals from her business along Inland Northwest trails to spur others into exploring public lands.
Absolute scenes in São Paulo after Brazil's goal 🇧🇷
Absolute scenes in São Paulo after Brazil's goal 🇧🇷
What Does Success Look Like in 2026 for Dolphins?
After moving on from veterans such as Tua Tagovailoa and Tyreek Hill, the upcoming season is about developing the Dolphins' roster, resetting the culture, and gaining salary cap flexibility for the future. The goal for any NFL team is not just to succeed in the immediate future but to establish a solid foundation for long-term success. After releasing Tagovailoa, Willis became the Dolphins' most significant free agent acquisition after he signed a three-year, $67.5 million contract with $45 million guaranteed.
Online violence against women in politics: what shapes political party responses to technology-facilitated gender-based violence?
Political parties have a primary role to play in tackling online violence against women and gender diverse politicians. While the prevalence and impact of TFGBV, such as coordinated disinformation campaigns, deepfake image-based sexual abuse or trolling are well documented, many parties are still building their knowledge on how to respond effectively and have not put in place internal practices and policies that respond to the rapidly evolving, poorly regulated digital ecosystem. About the ReportIn order to promote and protect fair and democratic participation in politics, this ALIGN Report explores what political parties are doing in response to TFGBV and what factors shape their action. The findings, based on existing literature and interviews with gender and politics professionals, indicate there are three sets of factors which donors, civil society and practitioners should consider when designing action to support political parties to respond to TFGBV internally. These are: (1) gender norms; (2) socio-political environment; and (3) internal party factors.Key messagesUnequal gender norms are ubiquitous across politics, shaping expectations of leaders to be strong and assertive, and practices of political parties to uphold masculinist values and sustain cultures of silence. These often lead to weak response to TFGBV against women politicians.The socio-political context can incentivise or disincentivise action, depending on the salience of gender issues, which are increasingly weaponised. Electoral competitiveness, domestic laws (i.e. quota requirements), and even the political system or global normative frameworks influence political will to act.Internal party factors that shape responses will vary across countries and contexts, but include: structures to enforce codes of conduct, policies and reporting mechanisms on (TF)GBV, political ideology, extent of centralisation of leadership, and crucially the meaningful participation of women in decision-making positions, not least through internal women’s wings.Party responses can be seen as a spectrum, with actions falling between active discouragement to address TFGBV to commitment to transform unequal norms and practices within the party.About the ToolkitTogether with the report, this ALIGN toolkit offers gender professionals and others working on democratic strengthening a set of guiding questions and reflection prompts to identify which responses could be most effective and suitable in different contexts. These actions can complement other solutions to TFGBV, such as regulations promoting safety by design. The assessment spans a broad range of factors including: (1) different manifestations of gender norms, (2) the socio-political environment and (3) internal party structures.Key messagesPolitical parties are duty-bound to take action internally to respond to the significant threats posed to women members and candidates, including from their own party colleagues, affiliates and political peers.Existing party approaches to TFGBV can be assessed along a spectrum which ranges from active discouragement and passive acceptance to minimal response and transformative change.To generate effective and context-appropriate solutions to TFGBV, it is important to consider how gender norms shape leadership expectations and internal party practices, while also analysing the impact of the socio-political environment. While actions to support women to stay safe online are very common, codes of conduct and measures to strengthen women’s voice and power in the parties are proposed as most transformative solutions.
How Colombia’s traditional midwives serve as lifelines to rural communities
Parts of Colombia are isolated, with no hospitals nearby. Experts say midwives can help bridge the healthcare gap.