SCROLL NEWS / DISCOVERY
Search headlines
Find the stories shaping the conversation.
Results for " rage " 5,977 found 🔀 AI-powered Shuffle
Millions drop Obamacare health coverage after subsidies expire and costs rise
Experts share why millions of people lost their Affordable Care Act health insurance plans this year after federal subsidies expired.
Millions drop Obamacare health coverage after subsidies expire and costs rise
Experts share why millions of people lost their Affordable Care Act health insurance plans this year after federal subsidies expired.
Rounding up Essentia media coverage from June
Each month, we share some of our favorite Essentia Health-related stories on the Newsroom.
Iran’s leverage over Strait of Hormuz snarls Trump’s push for a deal
Washington and Tehran are back at the negotiating table after a fragile ceasefire. But experts remain skeptical the two sides are close to a nuclear deal, even as calm oil markets reduce pressure to reach one.
Action! NSF–DOE Vera C. Rubin Observatory Begins Capturing the Greatest Cosmic Movie Ever Made
The wait is over: NSF–DOE Rubin Observatory, funded by the U.S. National Science Foundation and the U.S. Department of Energy’s Office of Science, is now capturing the cosmos in unprecedented detail, transforming the way we study the dynamic Universe.
UK living standards fall despite fastest growth in G7
Rolling coverage of the latest economic and financial news, as GDP quarterly national accounts show how UK economy fared in January to March 2026
ERISA’s Important but Limited Role in Health Care Cost Containment
Executive Summary Rising health care costs have brought renewed attention to the Employee Retirement Income Security Act of 1974 (ERISA) as policymakers and advocates look for new ways to address increasingly expensive employer-sponsored coverage. Leveraging requirements under ERISA appears attractive because other cost-containment efforts have had limited success, making the statute seem like a potential […]
Accessory Company Yanks Companion Cube Steam Machine Case Because It Never Actually Asked Valve For Permission
“We’re going to regret that decision for a very long time”
Meta Summer Sale Offers Massive Savings On Hundreds Of Quest Games
Meta Horizon Store's "Peak Summer Sale" is on, offering major savings on hundreds of Quest, games, apps, and DLC. Here are some of the best deals.
Reviews clear Telescope Health of fraud allegations; officials encourage Jacksonville residents to use HealthLink JAX
Multiple reviews have found no evidence of fraud, criminal wrongdoing or misuse of taxpayer dollars by Telescope Health, ending months of scrutiny over the Jacksonville company that operates the city’s HealthLink JAX program for uninsured residents.
Dbrand Forced To Pull Steam Machine Companion Cube
Mere after the reveal of the Valve Steam Machine, accessory maker Dbrand announced that it was releasing the "Companion Cube," a Steam Machine accessory that was modelled after the Portal weighted companion cube storage box. Following massive interest in the Companion Cube in the week since its anno...
Betsy Fischer Martin Will Lead Harvard’s Institute of Politics
The Emmy-winning journalist was a mainstay of political coverage at NBC for two decades.
About 3 million people have dropped Obamacare health coverage after subsidies expire and costs rise
The Department of Health and Human Services suggests the 13% drop is due to a federal crackdown on fraudulent enrollmentut, but health analysts believe it's more likely related to the Jan. 1 expiration of federal subsidies.
T-Mobile retires legacy plans, prompting price hikes and customer backlash
Average plan increase is $4 per month
‘Our goal is compliance and safety’: Brownsville mayor on Midtown Entertainment District shutdowns
Editor’s note: The video above is from previous coverage. HARLINGEN, Texas (ValleyCentral) — In a statement on Sunday, Brownsville Mayor John Cowen said the city’s priority is safety fo…
New data shows consumers dropped health coverage after Republicans let subsidies expire
Republican officials don’t deny the accuracy of the data, though they’ve repeatedly tried to argue that the reduction is a positive development. It’s not.
Xbox Expects The 'Component Crisis' To Get Worse For Consoles In 2027
Specifically for console storage and memory prices
Dave & Buster's Entertainment (NASDAQ:PLAY) Earns Market Perform Rating from Analysts at Citizens Jmp
Citizens Jmp began coverage on Dave & Buster's Entertainment in a report on Monday. They set a "market perform" rating for the company.
Ad Performance And Politics Steered Brand Dollars Away From LGBTQ+ Communities – But The Pendulum Will Swing Back
The current administration discouraged many brands and organizations from supporting and marketing to the LGBTQ+ community, including in June
Medicare will start covering weight-loss drugs on July 1 for the first time.
Millions of Medicare enrollees will gain their first-ever coverage for drugs for weight loss under a temporary pilot program that launches July 1.
Pioneering female sports editor honored with Hall of Fame induction
Sandy Smith is being inducted into the New Hampshire Legends Hockey Hall of Fame for her passion and coverage of sports.
Medicare will start covering weight-loss drugs on July 1 for the first time. Here’s what you need to know
Millions of Medicare enrollees will gain their first-ever coverage for drugs for weight loss under a temporary pilot program that launches July 1.
Wisconsin moms on Medicaid now get 12 months of coverage
Wisconsin’s new law extends mothers’ Medicaid coverage for a full year after birth. Medical experts say it will save lives.
Opinion | The Trump Vibe Shift Was Just a Mirage
The country does not love its president.
After her insurer denied coverage of medication, she ended up in the ER
After switching Medicare Advantage plans, a woman with a weakened immune system got tangled in the preapproval process, which the insurance industry has vowed to improve.
63,000 Long Islanders will lose Essential Plan health coverage July 1. Here's what to do.
Healthcare experts warn that many people kicked off the program will not be able to afford insurance and will avoid seeking care.
Virginians are feeling the effects of spiking health insurance premiums
Nearly 1 in 5 people using the state exchange has dropped coverage since January.
Bank of England chief economist warns against ‘complacency’ in fight against inflation
Rolling coverage of the latest economic and financial news
Millions drop Obamacare health coverage after subsidies expire and costs rise
Health analysts say the drop in enrollment was likely related to the Jan. 1 expiration of federal subsidies, which caused a surge in plan costs that resulted in many people being unable to pay their premiums.
Safety in the summer
According to the National Oceanic and Atmospheric Administration, July is, on average, the hottest month of the year in the United States.
Opinion: Bring back respect in politics
No matter your party or political persuasion, it is undeniable that American politics has taken on a tenor of anger and pessimism. This national mood has made American politics atoxic stew of rage, discontentment and despair. Many Americans don’t feel that the reforms they would like to see in their government are possible. These...
AI scientist company Edison Scientific tapped by team behind Metsera to create new biotechs
Edison Scientific and investment firm Population Health Partners are teaming up to leverage AI agents in drug discovery and development.
Millions drop Obamacare health coverage after subsidies expire and costs rise
Hampton Roads Virginia and Northeastern North Carolina News, Weather, Traffic and Sports.
Scientists Discover Ultrasound May Stop Arthritis Before It Starts
A new study suggests low-intensity ultrasound can influence immune cell behavior in ways that may reduce chronic inflammation and encourage tissue repair after joint injury.
Govee's smart nugget ice maker makes every iced drink feel like a luxury
For some people, the ice in a beverage is almost as important as the drink itself. That's the audience Govee had in mind when designing its latest ice
From Photo Backups to My Own Cloud Server: My Trip Into Home Data Storage
I just wanted to store my files safely. I ended up opening a Pandora's box of complications.
The Presidential Prayer Team
Each day, we invite you to join us in prayer for our national leaders. As mandated by 1 Timothy 2:1-2, we encourage prayer for those in positions of authority.
Maryland health insurance rates could rise 13.7% in 2027 under proposal
BALTIMORE — Maryland residents who buy health insurance through the Affordable Care Act marketplace could see higher premiums next year, with insurers requesting an average rate increase of 13.7% for
Bernstein Says Life Science Sector is Improving, Resumes Thermo Fisher Scientific (TMO) Coverage
Thermo Fisher Scientific Inc. (NYSE:TMO) is included among Billionaire Steven Cohen’s Top 11 Dividend Stock Picks. On June 26, Bernstein resumed coverage of Thermo Fisher Scientific Inc. (NYSE:TMO) with a Market Perform rating. It also set a $520 price target after the analyst returned from maternity leave. In a research note, the firm said “Many […]
Caminero to the moon: Rays 4, D-Backs 2
Before you could grab your hot dog, popcorn, and preferred pilsner beverage, the Diamondbacks took a 1-0 lead on a Geraldo Perdomo double, Corbin Carroll single, and a whiff of a tag from catcher Hunter Feduccia. In the bottom half of the first, Junior Caminero hit a thunderous, sky-scraping blast for his sixth homer in […]
PHOTOS | Multitude enjoy aerial entertainment at resurgent Texarkana Airshow
Sgt. 1st Class Benjamin Hall, assistant team leader, watches the ground to help the Golden Knights line up with their jump mark at the Texarkana Airshow on Saturday at Texarkana Regional Airport. Throngs of people lined a taxiway at the airport to watch the Army parachute team and other aerial entertainment. It was the first airshow in the city in nearly 30 years. See Monday's edition for extended coverage.
‘Noxious odors’ lawsuit involving organic residuals lagoon dropped by Fort Smith business owners
VAN BUREN -- A civil lawsuit focused on a widespread foul odor linked to an Arkansas River bottom organic residuals storage lagoon has been dismissed at the request of the plaintiffs.
States seek to lower drug prices by targeting the companies that manage them for health plans
TOPEKA, Kan. — As consumers worry about medication costs, states are trying to lower drug prices by reining in big companies that oversee prescription coverage for health insurers. Some of those companies, called pharmacy benefit managers, also own pharmacies, and one of them, CVS, has spent millions of dollars fighting
Millions drop Affordable Care Act coverage after subsidies expired
New federal figures show that about 3 million fewer people had Affordable Care Act health insurance plans in February compared with the same time last year.
3 million Americans have dropped Obamacare health coverage over past year, after Republicans let federal subsidies expire
KFF expects the total number of people in the government healthcare program to continue to decline throughout the year, potentially to a low of about 17.5 million from 19.2 million now.
New York Knicks Champion Mitchell Robinson Makes Heartfelt Post
Mitchell Robinson is coming off his eighth season in the NBA.The 28-year-old has become an extremely valuable player for the New York Knicks in that span.He is coming off a season where he averaged 5.7 points, 8.8 rebounds and 1.2 blocks per contest while shooting 72.3% from the field in 60 games.Knicks Champion Robinson Makes […] The post New York Knicks Champion Mitchell Robinson Makes Heartfelt Post appeared first on HEAVY.
Millions drop Obamacare health coverage after subsidies expire and costs rise
NEW YORK — About 3 million fewer people in the United States had Affordable Care Act health insurance plans in February compared with the same time...
City of Palms new downtown parking program: How local business react to the change
The Fort Myers City Council recently approved a change impacting parking rates at all three of downtown Fort Myers' parking garages. As it stood, visitors would receive one hour of free parking followed by a hourly rate. Now, the change has made it so visitors are entitled to two free hours followed by a hourly rate. Local business owners and managers said it's a good idea giving visitors more time to bask under the royal palms and indulge in some shopping. But one general manager points out a problem that did not start yesterday, but years prior.
Millions drop Obamacare health coverage after subsidies expire and costs rise
About 3 million fewer people in the United States had Affordable Care Act health insurance plans in February compared with the same time last year, according to new federal data. In the report releas...
Millions drop Obamacare health coverage after subsidies expire and costs rise
New federal figures show that about 3 million fewer people had Affordable Care Act health insurance plans in February compared with the same time last year. The Department of Health and Human Services...
Millions drop Obamacare coverage after subsidies expire, costs rise
New federal figures show that about 3 million fewer people had Affordable Care Act health insurance plans in February compared with the same time last year
Galaxy Z Fold 8 Release Date: New Details Before Samsung Launch
Samsung's Galaxy Z Fold 8 Ultra launches at Unpacked London on July 22. Here's what we know on specs, colors, storage options and release date ahead of Unpacked.
'Super puffy': Scientists ponder extreme low density of two planets
International researchers are engaged in a complex study of two planets in deep space that appear to have an average density lower than that of candy floss. The planets orbiting star TOI-791, located ...
Church pickles in dry storage, warm fish in restaurant inspections
See scores from local Lane County eateries in this week's write-up of restaurant inspections.
Germany news: Heat soars as political reforms split opinion
As Europe's heatwave rages, Germany continues to swelter with new records expected Saturday. Elsewhere, politicians bicker over reforms and industry blames train operator DB for billions in losses. DW has the latest.
Nigel Farage’s anti-WHO campaign moves to US with allies added to board
Relocation of Action on World Health raises questions over why Reform UK leader is involved in a US pressure group
Nigel Farage’s anti-WHO campaign moves to US with allies added to board
Relocation of Action on World Health raises questions over why Reform UK leader is involved in a US pressure group
States seek to lower drug prices by targeting the companies that manage them for health plans
Legislators across the U.S. are trying to lower prescription costs by reining in big companies that handle drug coverage for health insurers.
States seek to lower drug prices by targeting the companies that manage them for health plans
Legislators across the U.S. are trying to lower prescription costs by reining in big companies that handle drug coverage for health insurers.
Politics Unplugged Podcast: Headlines with Stacy Pearson and Marcus Dell’Artino
The Politics Unplugged panel breaks down a possible Arizona special session tied to ESA vouchers, union protections and ballot measures. The discussion centers on whether lawmakers could unwind late-night legislation that angered teachers, police and firefighters. They also examine Gov. Katie Hobbs’ political leverage and why both parties may have reasons to cut a deal. Later, the podcast turns to Trump tax cuts, Democratic Socialists, the White House reflecting pool controversy and the World Cup.
140 Kauai Coffee jobs saved through new land lease agreement
The lease agreement between Kauai Coffee’s parent company, Massimo Zanetti Beverage Group, and landowner Brue Baukol Capital Partners was finalized after nearly two years of negotiations
'The Invite' review: Olivia Wilde's sex comedy is outrageous fun
Seth Rogen, Penélope Cruz, and Edward Norton dazzle as flirty neighbors.
Consumer-Directed Health Care: Promise or Pitfall
This panel will examine the evidence and policy outlook for consumer-directed health care as a federal solution to expanded coverage, with a focus on affordability, access, and health outcomes.
Maryland health insurers want to raise premiums an average 13.7% for individual plans in 2027
Maryland health insurers want to raise premiums an average 13.7% for individual ACA plans in 2027
Six Kentucky Football Players Included on Athlon Sports’ 2026 All-SEC Team
Ty Bryant, Tavion Gadson, Lance Heard, Mi’Quise Humphrey-Grace, Coleton Price and Willie Rodriguez were honored by the magazine
Civility advocates look for ways to restore 'Iowa Nice' to campaigns, public discourse
A group of former and current officeholders are looking to encourage civility by encouraging civic participation and civil interactions.
An Unexpected Vocation: Jaibir Nihal Singh’s Journey from Film Student to Business Executive
Though trained as a filmmaker at Pepperdine University’s Seaver College, Jaibir Nihal Singh found a way to leverage his creative skills into a career as a successful innovator. Now, as a member of Forbes 30 under 30, Singh credits his education as the launchpad for his vocation, even if he never saw it coming.
Steam Summer Sale Offers Discounts On Hundreds of VR Games
Steam's Summer Sale is offering massive discounts on hundreds of VR titles right now.
Health experts keep Summerfest attendees healthy
On top of staying hydrated and wearing sunscreen, Aurora Health Care encourages wearing comfortable shoes and clothing.
Medicare will soon offer some older Oregonians weight loss drugs for $50 a month. Here’s how it works.
Medicare has long excluded coverage of GLP-1s prescribed solely for weight loss.
PENN Entertainment (PENN) Just Overtook the 20-Day Moving Average
Should investors be excited or worried when a stock crosses above the 20-day simple moving average?
PlayStation encourages Blu-ray adoption by deleting purchased movies from customer accounts
PlayStation encourages Blu-ray adoption by deleting purchased movies from customer accounts
In governor's race, voters face stark choice on immigrant healthcare
California’s next governor will face tough decisions on a highly controversial piece of healthcare policy: what to do about health coverage for the more than 1.4 million low-income residents without legal status.
The nation’s cartoonists on the week in politics
Every week political cartoonists throughout the country and across the political spectrum apply their ink-stained skills to capture the foibles, memes, hypocrisies and other head-slapping events in the world of politics. The fruits of these labors are hundreds of cartoons that entertain and enrage readers of all political stripes. Here's an offering of the best of this week's crop, picked fresh off the Toonosphere. Edited by Matt Wuerker.
UK food and drink exports fall as US tariffs and Brexit trade friction bites
Rolling coverage of the latest economic and financial news
It's Xbox's turn (again), as console prices keep going up
Microsoft announced a price hike for the Xbox Series consoles today, the third in little over a year. Effective August 1, the Xbox Series S, which launched in 2020 for $300, will cost $500 in the U.S. The Xbox Series X, which launched in 2020 at $500, will go for $800. This follows a round of PlayStation 5 price increases from Sony this spring, and a slow-motion increase for Nintendo’s Switch 2, which will kick in in the U.S. in September. (Mind you, there were also eight video game industry price hikes in six months of 2025). The chart up top shows the sudden ascent of console prices over the past year, a sudden surge in an already unusual hardware generation. Prices had been flat for years, now “up” is the new “flat.” Game console prices used to go down across the length of a console generation, but not this time around. Microsoft’s explanation for the new price hike today: We hoped another price increase would not be necessary, and we have spent the last several months working with suppliers on options. Unfortunately, console storage and memory prices have increased by more than 2.5x and we expect another doubling by the fall of 2027. The entire consumer electronics industry is struggling with the current components crisis, but the effects are particularly hard on consoles. Unlike phones, computers, speakers, and other consumer devices, consoles are typically not sold at a profit, but instead for less than they cost to make. This is an issue well beyond game consoles. Apple announced price hikes on its computers and tablets today as well. Game File is a reader-supported publication. To receive new posts and support my work, consider becoming a free or paid subscriber. Subscribe Item 2: Brutal Bungie cuts Bungie laid off “most” of its Destiny development team and some developers who worked on Marathon, the newest game from the struggling Sony-owned studio. A WARN notice issued by Sony to Washington State, where Bungie is based, tallied cuts impacting 292 workers, effective next month. That’s strictly for Bungie/Sony jobs in Washington and wouldn’t account for any elsewhere. The video I clipped below shows the redacted list of Bungie cuts filed to Washington State officials. As you’ll see, I had to scroll for a while… In a note emailed to PlayStation workers and published online, PlayStation game studios chief Hermen Hulst offered the following explanation for these latest cuts at Bungie: This is painful news, especially for talented colleagues whose roles have been eliminated. This decision was made only after extensive discussion and careful consideration, and I want to provide some context on how we arrived here. Over the past several months, together with Bungie leadership, we reviewed the studio’s long-term direction, development priorities, resource needs, and role within our broader portfolio strategy. We explored multiple alternatives before concluding that a reduction was necessary to align the studio’s resources with its current priorities and long-term goals. In 2022, Sony bought Bungie for $3.7 billion. The studio’s marquee game, the multiplayer live service shooter Destiny 2 was losing popularity at the time. Its next game Marathon, released earlier this year, has been well-reviewed but had a slow start. Bungie is renowned for making great shooter games, and Destiny fans have mourned the wind-down of Destiny 2. They’ve also expressed bewilderment over reports that Destiny 3 is not, per Bloomberg, immediately in the cards.
Monkey Business: Wild rhesus macaque spotted at Mount Dora hotel
A wild rhesus macaque was spotted at the historic Lakeside Inn in Mount Dora, Florida, spending about 45 minutes roaming the property and attracting attention from guests and staff. The hotel and local businesses responded with humorous, monkey-themed social media content, engaging the community. Wildlife officials cautioned the public not to approach or feed wild monkeys due to potential health risks and encouraged reporting sightings to authorities. The monkey has not returned to the hotel but has been seen elsewhere in downtown Mount Dora.
This autism therapy is covered by many insurers. Why does the military’s plan restrict it?
Logan Cabiao started applied behavior analysis therapy for autism when he was 2. Several years later, TRICARE, the military’s healthcare program, imposed major coverage restrictions.
Neuroimaging utilization in emergency departments has increased year-over-year for a decade
Researchers believe their new data could be used to better inform staffing coverage in modern radiology departments.
Making Our Own Luck
We are cross-posting a piece that former NIH official Kris Willis wrote for Macroscience. Kris is now the President and Founder of the Woodley Park Institute, for which I’m a board member. Picking winners or hedging bets? Federal science agencies have long wrestled with the question of how to ensure their billions of dollars of grants and contracts result in maximum benefits for Americans. On the surface, it might seem that a goal-oriented, interventionist style of management would be the best policy: prioritize our most pressing problems and distribute funding accordingly.This top-down strategy creates a unique hazard, though: bad choices can send resources in the wrong direction, resulting in slow progress that impedes the delivery of tangible benefits to citizens. Moreover, if decision makers pursue an applied advance when the underlying scientific principles remain poorly understood, they risk costly failures and a loss of support for the research enterprise at large. Examples include Nixon’s 1971 War on Cancer, undertaken on the premise that a cure could be achieved in less than a decade, the drive to build an operational commercial fusion plant by the mid-1990s, and the National Plan to Address Alzheimer’s Disease, which failed to produce the effective treatments and prevention strategies promised by 2025. The contrasting laissez-faire approach is to hedge your bets. If the path to an advance is impossible to predict, then the wisest choice might be to distribute funding to as widely as possible. The main risk of this strategy is that spreading funding thinly may limit the resources available to the most promising research, resulting in the same negative outcomes as the interventionist approach: limited support for the most promising topics, slow progress, and delayed returns. In reality, at science agencies like the National Science Foundation and National Institutes of Health, program managers navigate between these two extremes, setting some funds aside to target high-priority areas and using the rest to cover the widest possible range of meritorious proposals. This middle path seems like the most rational way to proceed, but it still requires making choices. How much should be set aside for high priority topics? What should those topics be? How should we define merit? Expert opinion can provide a helpful guide, but leading experts can have remarkably different opinions about what matters and what should be prioritized. Moreover, experts and administrators alike can be risk averse, giving an edge to high-profile, well-established concepts. What’s really needed is a data-driven framework to help guide decision-making, one that doesn’t simply repackage prestige or incumbency. Recognizing breakthroughs years in advance Many breakthroughs fail to attract funding or recognition at the earliest stages of development. Katalin Karikó, for example, spent years struggling to win grants for work on mRNA that would eventually win her and Drew Weissman a Nobel Prize. Similar stories can be told about Jim Allison’s groundbreaking studies leading to the development of cancer immunotherapy, Stan Pruisner’s demonstration that prions can self-replicate without DNA, or Robin Warren and Barry Marshall’s proof that Helicobacter pylori, not stress, causes ulcers. Yet at some point, the scientific community recognizes and responds to transformative breakthroughs like these. How does that change happen? And what if science funders could identify the areas that are on the cusp of a breakthrough? Those questions led my collaborators and me to study how scientists responded to past breakthroughs. Based on patterns in that data, we developed a means of predicting future breakthroughs, using biomedicine as a proof of concept. It’s worth taking a moment to describe how our approach works. Briefly, our prediction process begins by grouping the 18 million or so peer-reviewed papers in PubMed, the authoritative database of biomedical research, into roughly 50,000 unique topics. A small subset of these topics are so widely acclaimed as breakthroughs that they have been recognized with a major prize like a Nobel or a Lasker Award. We theorized that studying the development of these outliers over time, especially before they gained acclaim, was the key to identifying future instances of them. After defining topics, we chose 21 representative breakthroughs and asked what they looked like before they won prestigious prizes. To answer that question, we re-ran our topic-mapping algorithm repeatedly, winding back the clock one year each time, stringing together the years to follow the progress of each field as it grew and advanced. We found that in each case, the years leading up to a discovery followed a pattern: a burst of papers on a new, rapidly evolving topic, many of which quickly became influential. These characteristics—the percent of papers that are new, the percentage of papers that are brought in from other topics, and the influence of each individual paper—can all be measured separately for any given topic. Together, they act as a predictive signal that is detectable an average of five years before a transformative discovery is made, and up to thirty years before the discovery receives a major prize. Scanning the current research landscape for topics that display this signal allows us to predict what work will likely produce a future breakthrough. Each year we analyzed includes four or five signals, a number that appears to have remained constant across a twenty year time frame. In their classic work on the sociology of science, Bruno Latour and Steve Woolgar established that the desire to participate in a major discovery is an important motivator for scientists as they consider whether they should take up (or abandon) a research problem. Although further work is needed, the simplest explanation for our results is that this behavior is widespread enough to detect at scale. A foundational advance, or something like it, draws the attention of scientists and causes them to change the direction of their research. They vote with their feet, staking their own reputation and careers by publishing on and citing the new idea. That upswell of interest is the foundation of our breakthrough signal. What kind of research does our model identify as a breakthrough? After building a model based on the patterns in our 21 preselected breakthroughs, we tested it by identifying all early signals of discovery from 1994 through 1997. Of the 18 signals we found in that time period, 17 can be traced forward in time to a breakthrough. Examples include super-resolution fluorescence microscopy (see the image above), the directed evolution of proteins and enzymes (Chemistry Nobel, 2018), and sequencing the human genome (National Medal of Science, 2008). The discovery of the role of leptin signaling in obesity is a particularly interesting case study. Around 1950, scientists noticed the existence of a type of lab mouse that suffered from a unique inherited form of obesity. When given the freedom to choose their own diet, these mice ate more than normal and preferred food that was high in fat. Researchers had few clues as to why the animals overate; early experiments pointed to the existence of a soluble ob factor found circulating in the bloodstream that regulated appetite, but its identity was unknown. In 1994, Jeffrey Friedman and colleagues identified and sequenced the ob gene, noting that the protein it encoded appeared to fit the profile of a circulating factor. A year later, a trio of high-profile publications demonstrated that ob was a hormone that regulated body weight and fat deposition by regulating appetite. One of these was co-authored by Friedman, who christened it leptin from the ancient Greek word for thin. Using our model, the data from 1996 make it clear this advance would become a breakthrough. Scientists had flocked to study the biology of the new hormone, generating the flurry of new papers and citations required to produce a signal. One of these demonstrated that serum leptin concentrations reflected the amount of adipose tissue in the human body, providing clinical validation of the earlier mouse studies. Before the identification of leptin, scientists were unable to point to a specific molecule that controlled appetite and adiposity, so that it was impossible to rule out non-physiological causes of obesity; its characterization fundamentally changed our concept of weight gain. In 2010, Friedman and fellow pioneer Douglas Coleman were awarded a Lasker for the discovery. Our work also identifies breakthroughs in clinical practice and behavioral and social sciences, even though these areas are less likely to draw the attention of major prize committees. One example that falls into this category is the introduction of endovascular aneurysm repair, a minimally invasive surgical procedure for the treatment of abdominal aortic aneurysm, a leading cause of death among Americans over the age of 65. Relative to the previous standard of care, it reduces in-hospital mortality by almost four-fold. In 2017, Timothy Chuter received the American College of Surgeons’ prestigious Jacobsen Innovation award for his multiple refinements to the technique. Another under-recognized breakthrough identified by our model is the development of standardized survey instruments to assess the quality of life for HIV+ patients. The antiretroviral cocktails introduced in the mid-1990s reduced AIDS mortality, but treatment came with serious side effects. The new evaluations showed that patients whose disease progressed had worse physical functioning than Americans with other chronic diseases, while those who were asymptomatic maintained a health-related quality of life on par with the overall US population. This evidence made it possible for patients and activists to argue that even in the absence of a total cure, and in spite of the side effects, alleviation of symptoms was a worthwhile priority for clinicians. My colleagues and I have failed to identify any significant recognition for the physicians and health policy experts who pioneered this advance, although in 2016, researchers called for the World Health Organization to set targets for good health-related quality of life as part of its framework to end the AIDS pandemic. From forecasting to funding How should science funders use our predictions? Any serious discussion of what we should do with this new capability needs to begin with an understanding of its limitations. We can’t (and shouldn’t) invest all of our resources in the small number of topics predicted to produce breakthroughs. Innovative new fields are born from existing ones; they rarely arise de novo. If funders don’t maintain a diverse portfolio, the breakthroughs of tomorrow will have no antecedents. Think of this as eating the seed corn, or killing the goose that lays the golden egg. There are also multiple goals of funding beyond basic scientific discovery, including translating discoveries into clinical practice, developing new technologies, supporting economic development, and training new scientists. The investments needed to accomplish these goals are likely different from those required to support emerging breakthroughs. Finally, we must be aware that we may not capture every instance of a breakthrough. The concept is fuzzy, and not every significant discovery is recognized with a major award. Further, breakthroughs are rare, meaning that our dataset is, by necessity, small. This makes formal estimates of accuracy challenging. Although our overall success rate appears to be high, any one signal may turn out to be a false positive. We found one apparent example: the development of the third generation COX-2 inhibitors, Vioxx and Celebrex, which were much celebrated in the early 2000s as effective but non-addictive pain relievers, meets all the algorithmic criteria of a breakthrough. Five years after it received FDA approval, researchers demonstrated that Vioxx was associated with serious cardiovascular complications, and the manufacturer voluntarily pulled the drug from the market. Celebrex remains available, although like other NSAIDs, it carries an FDA warning for increased cardiovascular risk. Decision makers who were overly focused on the breakthrough potential of this research might have wasted substantial resources nurturing an area that ultimately proved to be a failure—but so would those who relied on expert opinion at the time. That said, the potential benefits of funding the next mRNA vaccine or cancer immunotherapy years earlier than we might have are large. When we can’t assume the outcome of an action, it’s worth conducting an experiment. Can targeted support for areas that are poised to produce a breakthrough increase the return on scientific investment without cannibalizing future advances? With the necessary administrative infrastructure in place, conducting this experiment would be straightforward. First, identify all the breakthrough signals between 2018 and 2023, select half at random, and commit to a decade of investment. For biomedicine, a six year window should yield about 30 topics with the potential to produce a breakthrough. Providing strong support to half of these might be accomplished for $300 million a year. That’s roughly half of the recent annual budget of the NIH Common Fund or around 20% of the fiscal year 2025 budget for ARPA-H. After five years, then again at ten, compare to see which group — the one that was actively managed, or the control — produced more breakthroughs, and on what timescale. Although we used biomedicine as an example, the same experiment could just as well be run for physics, materials science, or any other discipline. Any attempt to undertake such an experiment should keep three points top of mind. First, we can predict the topic of future breakthroughs, but the people and vision for how to move the work forward are still important. In practice, this means success requires active program managers with the expertise to develop the science and the authority to do so, including by recruiting investigators. Second, we would be wise to learn from the failures of past attempts to fund transformative research. High among these are funding modestly repackaged work, confusing the genuinely novel with the merely unfamiliar, and relying too much on incumbent investigators. All of these risks can be mitigated by thoroughly and intelligently integrating high quality data into portfolio management. Finally, we need to have patience. Even with strong funding support, producing a breakthrough takes time. If supporting breakthroughs is the best way to nurture the birth of new fields, we also need to accurately describe and properly manage the other two stages, so that we invest wisely throughout the productive lifetime of ideas and divest once they reach the point of diminishing returns. We would benefit from more study of all of these phases, especially the transition from one to another. More research could answer questions like: When does a breakthrough become an established field? How do the availability of funding, the size and characteristics of the available workforce, and the accumulation of evidence that disagrees with prevailing models affect a field’s decline? Exactly how do old ideas give birth to new ones, and can we speed up the process? The more we understand about the dynamics of scientific progress, the better we can maximize the odds that our curiosity leads to results. I’d call that finding a way to make our own luck.
These Churches Are Putting Family Before Politics
Close to 70 percent of Black children in America are born to unmarried parents. Nearly half live with a single mother. Both figures are significantly higher than the national average and reflect the steep decline in marriage among African Americans since the 1960s.
Microsoft is raising Xbox prices yet again — this time by up to $150
Microsoft said memory and storage prices have increased by "more than 2.5x" and it expects "another doubling by the fall of 2027."
From the Beginning, Politics Triggered Broadcasting
Media scholars argued that politics, not technology, shaped American broadcasting from 1927 on, repeatedly shielding incumbents from competition.
Ranking Big 12 recruiting classes via average commit distance
The Big 12 recruiting landscape continues to change as programs continue to shuffle throughout the conference. Texas Tech is pushing to sign the nation’s No. 1 class in the 2027 cycle and it firmly sits atop the league’s recruiting rankings. The Red Raiders are the only Big 12 team with a top-25 haul, per the […]
$10 Million Gift to UAB Aims to Improve Rural Health Care Across Alabama
A $10 million gift to the University of Alabama at Birmingham will help train more primary care physicians in rural communities and encourage them to stay and p
The Fourth Expedition
ARC Raiders is a multiplayer extraction adventure, set in a lethal future earth, ravaged by a mysterious mechanized threat known as ARC.
This beverage stock is likely to rise ahead of coffee business spinoff, Barclays says
The investment bank upgraded shares to overweight from equal weight.
Largo to launch open-container entertainment district near new City Hall
The city of Largo is establishing a specialized entertainment district that allows visitors to carry alcoholic beverages outdoors by the end of the summer.
New entertainment zone allows alcohol to-go
The city of Largo is establishing a specialized entertainment district that allows visitors to carry alcoholic beverages outdoors by the end of the summer. FOX 13's Blake DeVine reports.
Hims' obesity drug business may get boost as employers drop coverage
Telehealth provider Hims and Hers Health may get a boost next year from employers dropping coverage of weight-loss drugs like Novo Nordisk's Wegovy and Eli Lilly's Zepbound and Foundayo to rein in costs, investors and analysts say.
You Might Find Soccer Boring but American Sports Media Are All In
Coverage of soccer has exploded with this year’s World Cup.
Oil price falls to lowest level since before the US-Iran war; UK firms hope Burnham will ease burden
Rolling coverage of the latest economic and financial news
US says China trying to discourage states, businesses from engaging with Taiwan
China has been contacting U.S. states and private firms to discourage engagement with Taiwan and mischaracterising U.S. policy, but links with Taiwan should be expanded, three U.S. government departments said in joint letters.
Caitlin Clark Fans Outraged By WNBA 30th Anniversary Poster Snubbing
The WNBA is turning 30 years old this year. The women's basketball league, which launched 30 years ago, is celebrating three decades of ball in several different ways. One of them is a special WNBA 30th Anniversary poster, which went on-sale this week. "Bring a piece of WNBA history home. 🏀 ...
Kennedy scion Jack Schlossberg loses crowded New York City congressional primary
Kennedy family scion and political novice Jack Schlossberg lost Tuesday to New York state Assembly Member Micah Lasher, in a closely watched and crowded Democratic primary for an open congressional seat in the heart of Manhattan.
Brian Kelly in negotiations with CBS Sports for college football TV role: Source
Former LSU and Notre Dame coach Brian Kelly is in discussions with CBS Sports to join the network for its college football coverage.
Pints & Politics with WUNC's Colin Campbell in Pittsboro
To celebrate WUNC's 50th anniversary this year, we're hosting 50 events across North Carolina! Please join us on August 19 at BMC Brewing at The Plant in Pittsboro for Pints & Politics with WUNC Capitol Bureau Chief Colin Campbell! The event kicks off at 6 p.m.We'll chat about all things North Carolina politics, and your first pint will be on BMC Brewing in a special WUNC 50th anniversary pint glass! This event is free and open to the public, but an RSVP is encouraged as space is limited. Please RSVP at the link below to let us know if you are planning to join us. You can also submit a question for Colin in advance when you sign up to attend. We hope to see you soon!> RSVP Here
Online violence against women in politics: what shapes political party responses to technology-facilitated gender-based violence?
Political parties have a primary role to play in tackling online violence against women and gender diverse politicians. While the prevalence and impact of TFGBV, such as coordinated disinformation campaigns, deepfake image-based sexual abuse or trolling are well documented, many parties are still building their knowledge on how to respond effectively and have not put in place internal practices and policies that respond to the rapidly evolving, poorly regulated digital ecosystem. About the ReportIn order to promote and protect fair and democratic participation in politics, this ALIGN Report explores what political parties are doing in response to TFGBV and what factors shape their action. The findings, based on existing literature and interviews with gender and politics professionals, indicate there are three sets of factors which donors, civil society and practitioners should consider when designing action to support political parties to respond to TFGBV internally. These are: (1) gender norms; (2) socio-political environment; and (3) internal party factors.Key messagesUnequal gender norms are ubiquitous across politics, shaping expectations of leaders to be strong and assertive, and practices of political parties to uphold masculinist values and sustain cultures of silence. These often lead to weak response to TFGBV against women politicians.The socio-political context can incentivise or disincentivise action, depending on the salience of gender issues, which are increasingly weaponised. Electoral competitiveness, domestic laws (i.e. quota requirements), and even the political system or global normative frameworks influence political will to act.Internal party factors that shape responses will vary across countries and contexts, but include: structures to enforce codes of conduct, policies and reporting mechanisms on (TF)GBV, political ideology, extent of centralisation of leadership, and crucially the meaningful participation of women in decision-making positions, not least through internal women’s wings.Party responses can be seen as a spectrum, with actions falling between active discouragement to address TFGBV to commitment to transform unequal norms and practices within the party.About the ToolkitTogether with the report, this ALIGN toolkit offers gender professionals and others working on democratic strengthening a set of guiding questions and reflection prompts to identify which responses could be most effective and suitable in different contexts. These actions can complement other solutions to TFGBV, such as regulations promoting safety by design. The assessment spans a broad range of factors including: (1) different manifestations of gender norms, (2) the socio-political environment and (3) internal party structures.Key messagesPolitical parties are duty-bound to take action internally to respond to the significant threats posed to women members and candidates, including from their own party colleagues, affiliates and political peers.Existing party approaches to TFGBV can be assessed along a spectrum which ranges from active discouragement and passive acceptance to minimal response and transformative change.To generate effective and context-appropriate solutions to TFGBV, it is important to consider how gender norms shape leadership expectations and internal party practices, while also analysing the impact of the socio-political environment. While actions to support women to stay safe online are very common, codes of conduct and measures to strengthen women’s voice and power in the parties are proposed as most transformative solutions.