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“Parachute science” is failing the tropics, home to more than 80% of insect species
Insects quietly hold much of the natural world together, yet conservation efforts are overlooking the tropical regions where more than 80 percent of insect species live. Monash University researchers have developed a global framework to close this gap by combining scientific studies with museum collections, local expertise, citizen science, social media records, and new technologies.
Chris Mason: Burnham looks to show he will go further than Starmer with West Bank sanctions
It is hoped that coordinated action minimises the blowback to any one country from Israel or America, our political editor writes.
Cleveland County judge denies preliminary injunction in Norman Entertainment District lawsuit
On Tuesday, a Cleveland County Judge issued a preliminary injunction, pausing construction on Norman’s $1 billion Rock Creek Entertainment District.
The trail of clues that our planet might be heating faster than we realised
A curious online row over this summer's heatwaves points to a wider - and worrying - shift in climate science.
The trail of clues that our planet might be heating faster than we realised
A curious online row over this summer's heatwaves points to a wider - and worrying - shift in climate science.
ABC denies 'inaccurate' report 'Jimmy Kimmel Live!' will end in 2027
Amid speculation about Jimmy Kimmel's late-night tenure coming to an end, ABC is pushing back. On Sept. 8, Page Six reported that this season of "Jimmy Kimmel Live," will be
Oklahoma business feels impacts of Canadian tariffs
Failed trade negotiations in August led to the U.S. putting a 50% tariff on $20 million of Canadian products.
The 98 Biggest TV Show Flops, Bombs and Misses in the First Half of 2026
(Welcome to the Entertainment Strategy Guy, a newsletter on the entertainment industry and business strategy. I write a weekly Streaming Ratings Report and a bi-weekly strategy column, along with occasional deep dives into other topics, like today’s article. Please subscribe.) In July, I updated my look at how the “streaming bubble” popped since 2023, showing the decline in streaming TV shows over time. But after compiling and analyzing and writing about over one hundred TV show flops in the first half of 2026—I counted 99 “nominees” and there are even more honorable mentions—I couldn’t have told you that the number of shows is going down. When it comes to scripted, English-language TV shows, it feels like we have as many bombs as ever. I don’t keep a specific count, but some streamers probably had as many flops as they’ve ever had.1 That’s right, it’s time for part two of my analysis of the biggest flops, bombs and misses on streaming in the first half of 2026. Two weeks ago, I took a look at films. Today, TV shows. If you want to read the full methodology for how I assemble this list, you can find it at the bottom of this article. In short, this list is… ...scripted and unscripted TV shows,...from the nine major streamers,...in the US (using US-only ratings),...excluding true crime, kids and foreign-language shows,...that got no/poor ratings,...from Jan-2026 to the end of June-2026. Reminder: this article does not represent my personal opinion—many of these shows are great!—but I follow the data, and a miss is a miss and a bomb is a bomb. Also, price matters. If a TV show costs north of $100 million, it needs to get lots and lots of streaming viewership to justify that budget. As with past editions, I ordered this list by streamer, going from best (fewest flops) to worst (the most misses)—taking the size of the flops into consideration—and like the last edition, three or four streamers vied to take the win/loss of having the most flops. (But the actual winner is no surprise.) I try to avoid tooting my own horn too much, but seriously, in just under 5,000 words (including the methodology section) I provide a mostly comprehensive overview of the eight major streamers (Netflix, Disney+, Prime Video, Hulu, HBO Max, Peacock, Paramount+, and Apple TV) for the first half of the year, mentioning most of their hits and all their misses. It summarizes the entire first half of 2026! If you want to support this work, please subscribe. Subscribe Tubi Big Mood Boarders The Freak Brothers Twenty Twenty Six Honorable Mentions: Busted on Bodycam, Deestroying the Pitch, Destination World Cup 2026 I don’t think that Tubi spends all that much making or (mostly) licensing these original TV shows—Big Mood, Boarders and Twenty Twenty Six all come from the UK—but they’re not free and they didn’t chart anywhere. Winner: The Freak Brothers Have you even heard of this show? It’s an animated comedy...that’s on its third season! And Pete Davidson, Woody Harrelson, John Goodman and Tiffany Haddish all provide voice talent for it. Yes, animated shows don’t cost as much as live action shows, but cheap isn’t free! So a show with this level of talent needs to perform better. Disney+ Daredevil: Born Again Star Wars: Maul – Shadow Lord Honorable Mentions: Behind the Attraction, Donna Hay Coastal Celebrations, We Call It Imagineering Disney+ doesn’t make all that many original shows anymore. They had two flops, and one was animated. Their one not-a-miss show, Wonder Man, got just good enough viewership to not be considered a “miss”...but it’s since been cancelled. At this point, Disney has pivoted entirely away from making big budget TV shows for Disney+ to making...almost nothing for Disney+? Sure, Disney’s spending circa 2019-2022 was unsustainable, but now they’re pivoting too far in the other direction. At some point, Disney needs to stop shifting strategies so wildly. Really, Disney should have made fewer shows for Disney+ at launch and the shows they did make at that time needed to be made at more reasonable budgets. And they should adopt that strategy now. Winner: Daredevil: Born Again Daredevil, the Marvel Comics character, is on my personal Mount Rushmore of favorite superheroes, so it pains me to give him the win/loss today, but this show deserves it. I’ll repeat my hot take from last spring: “Based on his popularity, Daredevil should be in movies, and probably ones that cost a lot less than the MCU’s usual price tag. Disney/Bob Iger/Ike Perlmutter (who, based on reporting, made the decision) made a huge mistake selling TV shows to Netflix in the 2010s, thus limiting this character to the small screen. Daredevil could have anchored Marvel’s post-Infinity War plans, and if he did, the MCU would probably be in a better place than it is now.” HBO Max We’re just getting started with this issue, but the rest is for paid subscribers of the Entertainment Strategy Guy, so if you’d like to find out… What four streamers had the most misses... HBO’s strong start to 2026… The caveat to Peacock’s turnaround this year... Paramount+’s key man problem… What country isn’t delivering hits for Netflix or Hulu... The cavalcade of stars on a streamer where no one is watching their shows... Across nearly 5,000 words of analysis… And a lot more... ...please subscribe! We can only keep doing this great work with your support. If you’d like to read more about why you should subscribe, please read this article about the Streaming Ratings Report, why it matters, why you need it, and why we cover streaming ratings best.
The set-pieces: Real Madrid 2-1 Inter
Madrid won the first contact from two of their seven deliveries and generated four shots, three of them in the second phase
Live results: Delaware primary election
See Delaware election results and maps for the 2026 primaries.
Live results: Rhode Island primary election
See Rhode Island election results and maps for the 2026 primaries.
Live results: New Hampshire primary election
See New Hampshire election results and maps for the 2026 primaries.
Newcastle battle past Millwall to reach League Cup fourth round
Newcastle battled into the League Cup fourth round as Joe Willock's late goal sealed a bruising 1-0 win against Millwall on Tuesday.But Newcastle survived to keep alive their bid to win the League Cup for a second time in three years.
Local businesses brace for gigantic cargo moves starting next week
Locals anxiously waiting for superloads of heavy equipment — weighing up to 380 tons — to travel through their towns will have to hold on until next week. The first trip, on a giant, specialized truck, is expected to leave a dock in Gilpin’s Schenley section on Monday morning. Officials
Porto vs Manchester City Match: Champions League Live Updates
Porto hosts Manchester City at the Estádio do Dragão on Tuesday, September 8, in the opening round of the 2026-27 UEFA Champions League phase. Both teams enter the European opener in strong domestic form and will be looking to start their Champions League campaigns with a positive result. Kickoff is scheduled for 8 p.m. BST, […] The post Porto vs Manchester City Match: Champions League Live Updates appeared first on HEAVY.
Pittsburgh entrepreneur donates storage systems to Seton Hill business, technology school
The founder of a Pittsburgh-based digital storage solutions company donated $35,000 worth of equipment to Seton Hill’s cybersecurity and computer science programs. Gene Leyzarovich, former Jetstor CEO, founded the Bloomfield company more than 30 years ago while studying at the University of Pittsburgh and working night shifts at UPMC. The
Questions over Tennessee's rural health grant program
Nashville News, Weather, and Sports
Apple event expected to deliver foldable iPhone and debut of new CEO John Ternus
Beloved Hershey Christmas attraction won’t be returning this year
However, several new attractions will be included in the Christmas Candylane season at Hersheypark.
Three Rivers Health Department reopens
Three Rivers Health Department reopens after tornado damage earlier this year. (Sept. 8, 2026)
Philz Coffee workers in California file to form union to negotiate new contract
The notice was delivered Tuesday
Yankees At-Bat of the Week: Austin Wells (9/2)
Wells’ bat has come alive right when the Yankees need it.
Shutterstock Appoints Three Accomplished Business Leaders to Board of Directors
/PRNewswire/ -- Shutterstock, Inc. (NYSE: SSTK), a family of brands delivering scalable creative and GenAI solutions to help customers fuel great work, today...
Puppy Pals Live Wags Its Way Back to the Niswonger
an Wert, OH [Sept 7, 2026] - Get ready for an afternoon filled with four-legged fun as Puppy Pals Live returns to the Niswonger Performing Arts Center on Sunday, September
Rogers mixed-income community opens after $13 million investment
Three-story, 60-unit Olive Street Apartments recently opened at 700 N. 24th St. in Rogers. Roughly $13 million was invested in the attainable housing project, supported by the Walton Family Foundation....
Exclusive: Two of gaming’s biggest names are making a big investment in gaming’s future
The first thing to know about the Nova Games Foundation is that it isn’t about The Game Awards. And it’s not about PlayStation. The ambitious new grant program is the brainchild of Geoff Keighley and Mark Cerny. Keighley is the host of The Game Awards, Summer Game Fest and Opening Night Live. Cerny is a game designer of some 45 years and the lead architect for the PlayStation 4 and 5. But this new thing, which they’re revealing through Game File, isn’t about their day jobs. It’s an unaffiliated, standalone philanthropic project. It’s a bet on the artistic future of video games and a way, they tell me, to give back. “I’m nearing the end of my career,” Cerny recently told me over email. “I’m not done yet, but paying it forward—in the best way possible—is very much on my mind these days,” The Nova Games Foundation is a university-affiliated fellowship program, intended to offer six-figure grants to 20 young game designers each year, potentially for decades to come. It will offer no-strings-attached funding along with mentorship from games industry leaders, a combination intended to aid the development of groundbreaking new games, Cerny and Keighley told me. Nova will begin accepting applications in December, from class of 2026 and 2027 students from 13 affiliated gaming programs at universities in eight countries. The schools working with Nova include the New York University and the University of Southern California in the U.S., along with Abertay University in Scotland, Cnam-Enjmin in France, TH Köln in Germany, and the Royal Melbourne Institute of Technology in Australia, Cerny and Keighley said. The plan: $100,000 per recipient, with about a quarter of Nova fellows eligible for up to $500,000 more for projects that are shaping up particularly well. Payments will be delivered based on development milestones, and recipients will own their games. Nova will help promote the work, and developers will be free to pursue the publishers and platforms of their choice. Nova can help introduce fellows to publishers, but won’t take a cut. “I’ve always wanted to give back, but given my role in the industry, I’ve never felt it appropriate to commercially invest in games,” Keighley told Game File. “I’ve never owned stock in a game company or taken a financial stake in a game. Nova is philanthropy: we aren’t taking equity or looking to recoup the grants. The return we’re hoping for is creative—helping new voices make games and find their footing. “Mark and I have each made multi-million-dollar donations to establish the foundation, and we intend to keep contributing. We hope others will join us.” Cerny and Keighley have already hired an executive director, John Maconga, and a head of grants, recent Game Developers Conference director Ashley Corrigan, to help launch the effort. They’re working to recruit game industry leaders to join the effort. Keighley says “dozens of leading game directors have already expressed interest in contributing their time.” To name one, they’ve already gotten Josef Fares, lead designer from It Takes Two and Spit Fiction studio Hazelight on board with a donation and pledge to help out. “I’m proud to support Nova because it gives the next generation of creators the freedom to explore their creativity and hopefully bring their unique visions to life,” Fares told Game File. A plan forged from a friendship Keighley and Cerny have known each other a long time. It’s been so long, Cerny isn’t even sure exactly when they met. “We travel in much the same circles and I’m sure first intersected in the 90s or early 2000s,“ Cerny said. Keighley thinks it might have been during his stint writing a column about the mid-’90s console 3DO for a gaming magazine while Cerny was working on games with Crystal Dynamics or on Way of the Warrior with Naughty Dog. They became genuine friends about a 10 years ago, Keighley said, as they bonded over a shared love of games and a hope to improve the industry. “About a decade ago, we started having dinner a few times a year in LA,” Keighley said. “Just to catch up on life and the industry. Those conversations continued over Zoom during COVID. Nova grew out of that friendship and a question we kept coming back to: ‘What could we do to help the next generation of game directors get started?’” Keighley credits Cerny with the idea to figure out a way to put their money and time back into the industry. At one of those dinners, Keighley proposed the idea of a fellowship program. He’d recalled applying for a Rhodes Scholarship when he was younger. “Spoiler: I didn’t get it,” he said. He’d admired the MacArthur Foundation’s so-called “genius grants.” He liked these kinds of programs that recognized people’s talents and gave them the financial boost and the freedom to realize their potential. With Cerny, he had pondered what a game industry version of that could be. Keighley liked the idea of centering the fellowship on students, drawing inspiration from the accomplishments of Jenova Chen, the USC game design graduate who went on to lead the creation of gently moving, ambitious games such as Flower and Journey. Keighley also thought it could be useful to help promising graduates bridge the transition from student to professional. “Joining an established studio isn’t always possible—especially in today’s market—and even then, it isn’t the right path for everyone,” Keighley said. A fellowship, he realized, could give “graduates the time, resources and guidance to pursue a game of their own and not worry about the commercial viability.” As the idea took shape, Cerny also saw an opportunity to enable more games of a certain type: “The target with the grants is games as an artistic medium,” Cerny told me. “We like to say games with ‘artistic, literary and societal value.’” He added: “I’m a pretty big gamer myself, though I tend to gravitate towards the smaller and more unique or artistic titles, games like Neva, Abzu, Gorogoa, Stray or Outer Wilds. I was just playing and Roger on a flight to Japan, and was getting misty eyed to a degree that I was concerned that a flight attendant would ask me if I was OK. “So one fun benefit here is the games that will come out of the Nova Games Foundation – I can’t wait to play them myself.” Cerny believes it will also be useful for Nova fellows to hone their craft and team leadership skills. “We are looking for the next generation of visionaries,” he said. “The trick is that they will also need to have the executive function necessary to drive a small project to completion.” Game File is a reader-supported publication. To receive new posts and support my reporting, please consider becoming a free or paid subscriber. Subscribe Going big with this Keighley and Cerny may have started Nova and may be the ones primarily backing it right now, but they’re dreaming of something that goes beyond them. “Mark and I may have helped get it started, but one of our measures of success is that Nova grows into something the entire games industry feels a sense of ownership in,” Keighley said. “Our ambition is to build a lasting endowment supported by people and companies across the industry, and an equally broad community of creators willing to give their time and experience to the next generation.” The industry has a lot of knowledge that it can pass to the next generation, Keighley said: “Nova can hopefully become a way to connect that generosity with talented young creators at the moment when it can make the biggest difference.” Cerny, who told me he believes Nova can mature “over the next 10 or 20 years,” sees an opportunity to give generations of game makers momentum. “The industry has changed immeasurably since I started in games in 1982,” he said. “These graduates have talent, training and tools that outclass what we had back in the day by an astonishing amount. But they face a tough road ahead getting traction in the industry, and many could benefit from our support. We want to be there to give it to them.” “There’s a personal side to this, too,” Keighley said. “I don’t have children, and I’ve spent a lot of time thinking about what I can do for future generations. Games have been my entire career. I’ve been incredibly fortunate, and helping someone else build a life in this industry feels like a meaningful way to give back.” Cerny’s oeuvre dates back to Marble Madness and Sonic the Hedgehog 2. He has stood on stage multiple times to reveal the future of PlayStation hardware. He’s been an executive producer for a string of modern PlayStation classics such as The Last Guardian and Marvel’s Spider-Man. Nevertheless, of Nova, he said, “It’s certainly not like anything I’ve done before.” Nova Foundation applications will be due in December and the first wave of fellows will be announced in March 2027. A full list of participating universities and steps students and recent graduates can take to apply to become a Nova Fellow is forthcoming.
Santa Cruz to build a new type of mental health care center for youth
Serenity Smith, who lived at a residential treatment facility in Santa Cruz in 2024, drives to work in Aptos on Monday, Aug. 31. (Amaya Edwards — Santa Cruz Local/CatchLight Local) Located at: 5300 Soquel Ave., Santa Cruz, CA 95062. Call (831)540-4141. Behavioral Health Resources
Tim Montgomerie quits Reform following suspension
The political commentator, who defected from the Tories 18 months ago, was suspended from Reform UK last month.
Business Aviation Insight. Reassessing Large-Cabin Value After the Falcon 900LX’s Final Delivery Year
Challenger 650 – Photo Credit: Bombardier The Falcon 900LX and Challenger 650 sit at opposite ends of a large-cabin segment that, on 2026 data, now spans nearly $19 million in …
Bruins Announce Roster, Details for Rookie Camp and Prospects Showcase
The Boston Bruins prospect pool is heading to Buffalo. On Tuesday afternoon, the Bruins announced the roster, schedule, and livestream […]
Roundup: Using AI to better integrate virtual modalities into care delivery
Artificial intelligence enhancements in telehealth aim to bolster care continuity while virtual nursing extends bedside care. Also, Zocdoc integrates with Google Gemini to book appointments while Sword Health is set to acquire Headspace's parent company.
Apple Releases iOS 26.6.2
Apple today released iOS 26.6.2 with a fix for "an issue that prevents downloading a software update over a cellular connection". The minor software update is rolling out now for the iPhone 11 series and newer. To update your iPhone, open the Settings app and tap on General → Software Update. It might take a few minutes until the update is visible to everyone. iOS 26.6.2 arrives approximately three weeks after iOS 26.6.1, which delivered security fixes.
How to watch Apple's foldable iPhone announcement
Apple's annual iPhone event will stream live on September 9 at 10 AM PDT, and we're expecting big news.
Booster group pushes to keep Downtown Pittsburgh businesses viable
The Pittsburgh Downtown Partnership has sought to bring more small businesses into the Golden Triangle in recent years — and now it’s launching a concerted effort to keep them there. Dubbed Business Boost, the initiative is meant to support small businesses and ensure they can last Downtown long-term, Pittsburgh Downtown
Health: The Fight For The Health Of 9/11 First Responders
A quarter century after 9/11, the health of those who responded to the attacks continues to be affected.Some 3,000 people died across three locations that day. An estimated 400,000 people were exposed to toxic contaminants and risked physical injury in the hours and days that followed. That’s according to data from the Centers for Disease Control and Prevention.Since the dust and debris have settled, more than 96,000 have been diagnosed with physical and mental health conditions related to 9/11.In 2010, President Barack Obama signed the James Zadroga 9/11 Health and Compensation Act, establishing the World Trade Center Health Program and reopening the 9/11 Victims Compensation Fund. Today, more than 150,000 people are enrolled in the program.But that program wouldn’t exist without the advocacy of survivors and first responders who put their bodies and lives on the line following the attacks. How did that fight for care unfold?For more information about the Rutgers WTC Health Program, click here. And to learn more about applying, click here.Find more of our programs online. Listen to 1A sponsor-free by signing up for 1A+ at plus.npr.org/the1a.
Apple Event 2026 Live: The First Foldable iPhone, iPhone 18 Pro, Apple Watch 12 and More
We're counting down to Apple's Sept. 9 unveiling of the foldable iPhone Ultra. It's the first keynote helmed by new Apple CEO John Ternus and expected to be Apple's biggest event in years.
New law to force tech firms to prevent children from taking nude images
The government said it will legislate "as soon as they can" but may "reassess" its plans if firms make the desired changes sooner.
How to Watch Tyler Perry's Assisted Living Season 7 Premiere
Watch Tyler Perry's Assisted Living live with TV channel, start time and streaming info. Stream Season 7 Premiere on Fubo — no cable required.
Gone but not forgotten – Indigent Remains Ceremony 2026
The King County Medical Examiner's Office Indigent Remains Program provides burial for King County residents who have died without resources or family to claim their remains for a proper burial. The next ceremony to remember these individuals will take place on Wednesday, October 7, 2026, at 1 p.m. at Mt. Olivet Cemetery in Renton (100 Blaine Ave NE). It’s open to any member of the public who wishes to pay their respects.
Clive Davis’ $35 million art trove, including Warhol and Hockney, heads to auction
The works owned by Clive Davis includes David Hockney's portrait of Andy Warhol and Warhol's portrait of Aretha Franklin, among other works collectively estimated to fetch more than $35 million.
Sanford Health Patient Advances Suit Over Meta Data Disclosures
Sanford Health Corp. failed to convince a federal judge to toss a proposed class action alleging the Minnesota-based health system collected and disclosed patients’ personal information in violation of state and federal laws.
Miley — Bass Persuades: Live at the Hollywood Bowl: Where and when to buy tickets to see Miley Cyrus
Here's how to get tickets to see Miley Cyrus in concert.
29 More Days Isn't a Business Plan (Opinion)
The one-month reprieve on the impending ban on many hemp products doesn't give small businesses enough time to make the decisions required to keep their companies running. Dylan Raap, CEO and founder of cannabis and hemp business Upstate Elevator, asks Congress to ‘tell us what the rules are and give us enough runway to live by them.’
Dan Campbell Reveals Detroit Lions Guard Plan for Week 1
Dan Campbell is keeping Detroit's left guard competition alive entering Week 1. Christian Mahogany and Ben Bartch will split first-team practice reps, and both could see action against New Orleans.
Clive Davis’ art collection heads to Christie’s auction
Clive Davis’ largely unseen art collection, featuring works by David Hockney and Andy Warhol, could fetch more than $35 million at Christie’s.
Liverpool’s hunt for a new sporting director: Julian Ward and the standout internal options
FSG president Mike Gordon is leading the search for Richard Hughes' replacement, with both internal and external candidates being considered
Netflix VP of Global Live Sports & Entertainment on WWE: "They’ve been great partners, and we’re thrilled with the results so far" - POST Wrestling | Podcasts, News, Reviews
Gabe Spitzer, a Vice President at Netflix, spoke with Richard Deitsch on the Sports Media podcast regarding their relationship with WWE.
Live Results: Rhode Island midterm primaries
Rhode Island Gov. Dan McKee faces a tough Democratic primary challenge Wednesday in his bid for a second full term.
Live Results: New Hampshire midterm primaries
The race to replace retiring three-term Democratic Sen. Jeanne Shaheen is one of a handful across the country that could determine control of the U.S. Senate for the second half of President Donald Trump’s final term.
Scientists call for joint efforts to preserve nomadic heritage
At the International Scientific and Practical Conference “Cultural Heritage of the World’s Nomadic Peoples: Preservation, Study, and Development”, scholars and experts from 23 countries urged unified action to safeguard the cultural diversity of nomadic peoples and ensure traditions remain alive for future generations, Qazinform News Agency cites Kabar.
1984 Flag Maker Business WAVY Archive
Hampton Roads Virginia and Northeastern North Carolina News, Weather, Traffic and Sports.
1984 Virginia Beach Business Tax Changes WAVY Archive
Hampton Roads Virginia and Northeastern North Carolina News, Weather, Traffic and Sports.
The New York Times: A new editor for Politics
Ben Shpigel, who’s guided fast-breaking coverage on Live and Sports, will help elevate real-time political coverage at The New York Times.
Holman Assumes Full Ownership of ARIZA, Unifying 30-Year Mexico Business Under the Holman Brand
MOUNT LAUREL, N.J., September 08, 2026--Holman Assumes Full Ownership of ARIZA; the acquisition delivers a seamless fleet leasing and management solution for customers across North America.
Pete Davidson reveals emotional 9/11 connection to Michael Strahan: ‘You put me on your shoulders’
In a new documentary, Davidson and Strahan recall and relive the happy meeting that took place amid tragedy and pain.
AZ's R&D chief Barr touts internal 'science success story' after IL-33 antibody's stellar showing in COPD
With a detailed data drop that AstraZeneca’s R&D chief described as an internal “science success story,” the British Big Pharma has secured an FDA priority review for what it believes could become a flagship biologic in chronic obstructive pulmonary disease (COPD). In detailed results from the late-stage Oberon and Titania trials—first teased in March and detailed in full at the European Respiratory Society Congress in Barcelona this week—the drugmaker laid out the extent of its IL-33 inhibitor’s potential to reduce moderate and severe exacerbations in a wide range of COPD patients still struggling with those “lung attacks,” as AstraZeneca’s Sharon Barr, Ph.D., called them, despite using standard-care inhaled therapy. In the headline results, a 300 mg dose of tozorakimab given once every four weeks curbed those moderate and severe exacerbations in the studies’ primary population of former smokers by 29% in the Oberon study and 34% in Titania. In the overall population of both current and former smokers, these reductions were 30% and 29%, respectively, versus placebo and inhaled standard of care. The benefits also extended to clinically meaningful exacerbation reductions in all prespecified patient subgroups and specifically turned up promising signals in patients across a range of blood eosinophil counts, with Barr telling Fierce that “it’s the details that make this even more exciting than the high-level results that we’ve already shared.” In fact, during AZ’s tozorakimab poster presentation at the ERS 2026 Congress this past weekend, attendees were so enamored by the data that event organizers had to encourage people to clear the room and look at the other presentations on offer, Barr said in an interview. “I think it really speaks to the fact that there is a lot of buzz around these data because the entire respiratory community has been so desperate for new therapies for these patients,” she explained. The respiratory disease continues to represent a “staggering unmet medical need,” Barr said, highlighting the COPD exacerbations that the Oberon and Titania studies homed in on, which she added carry a greater mortality risk than a heart attack. “When a patient has a severe exacerbation, only about half of them are still alive within three and a half years,” she pointed out. As for tozorakimab specifically, Barr christened the molecule “an AstraZeneca science success story,” harkening several years back to the point at which researchers began to explore IL-33 as a driver of respiratory disease, and COPD in particular. At the same time, “there was still so much that wasn’t understood,” she admitted, highlighting the insight that IL-33 signals through both ST2 and EGFR through the RAGE pathway, a discovery Barr attributed to AstraZeneca's own scientists. Understanding the need to tackle both pathways in COPD—and aware of competitor candidates in the hopper, including one that bound ST2—the company ultimately had to make some “courageous decisions,” Barr said. These included taking a prior COPD molecule offline and going back to the drawing board to reinvent its potential IL-33 label “to make sure that we had a molecule that could block signaling through both arms of the pathway, through both the reduced form and the oxidized form, knowing that we wouldn’t be first, but striving to be best.” “When we put [tozorakimab] into the clinic, we firmly believed that we had a differentiated molecule, and we saw the other molecules blocking just ST2 or partially blocking IL-33, unable to deliver two positive pivotal studies in COPD,” Barr explained. “We kept marching forward because we believed our molecule was differentiated, and now I think we have the clinical validation that supports that.” Ultimately, AstraZeneca finds itself on much better footing these days when it comes to potential biologic rivals to tozorakimab in COPD. Sanofi and Regeneron’s Dupixent, for instance, is approved to treat COPD exacerbations in patients with high eosinophil counts, but not low ones. Meanwhile, the future has become cloudier for other next-gen IL-33 candidates from Sanofi and Regeneron, as well as Roche, which have suffered trial flops in recent years. One other potential ingredient for AstraZeneca’s success in its duo of studies was that the company was “ambitious in the trial design, willing to look at an all-comers population,” Barr said, “and willing to enroll the most severe patients.” Prior studies for would-be biologics rivals in COPD “avoided enrolling” those patients, she pointed out. She also highlighted the Big Pharma’s painstaking design of exacerbations in its trial, which “gave us a very rigorous readout,” and pointed to “the extra effort and investment” the company put in to understand the effect of mucus plugs in patients. Barr described mucus production as a “key feature in disease diversity,” noting that mucus plugs—obstructing clumps of mucus that block patients’ airways—are associated with worse outcomes in COPD. In its data announcement, AstraZeneca noted that an integrated analysis of Oberon and Titania found tozorakimab “demonstrated a reduction in patients’ mucus plug score,” with the pharma claiming its biologic is the first to deliver such results in a broad COPD population. “So being able to reduce those mucus plugs, we expect, is an important part of driving benefit for patients who are living with COPD,” Barr said. Again touching on the breadth of the study populations, Barr added that tozorakimab “worked across all eosinophil levels in both current and former smokers across all levels of lung function,” which she suggested “really simplifies decision-making for clinicians, and it allows them to offer therapy to the broadest possible patient population.” In the highest patient eosinophil count group, tozorakimab helped chart a 43% reduction in exacerbation risk, which Barr stressed were “unprecedented data.” In the mid-level group, AZ’s drug delivered a 23% reduction and, in the lowest group, a 34% reduction in eosinophils, which Barr said suggests efficacy “in all patient subgroups.” As for AZ’s recent guidance upgrade on the medicine’s sales opportunity, the lift from a $3 billion to $5 billion range to $5 billion plus was informed by multiple factors, Barr said, including the fact that “in 2024, there were multiple competitors, and there aren’t anymore.” Additionally, “we know that this is a massive unmet medical need, and this is a really incredible set of data that we think will be very convincing to the clinical community,” Barr said. Looking ahead to a potential evolution of the COPD treatment landscape, Barr noted that most patients start treatment in the community with an option like a triple therapy, and for them, having an option like AstraZeneca’s inhaler Breztri will remain a “really important part” of that journey. But of the patients uncontrolled on triple therapy, which Barr described as “about half of them today,” just a “small fraction” are currently eligible for biologic therapy, which she emphasized AstraZeneca is working to change. Understanding that COPD is not a “one-size-fits-all” disease, AstraZeneca is also looking at its antibody drug Tezspire for patients with T2-driven disease, and the company continues to think about new mechanisms for tackling COPD through both systemic and inhaled drugs, Barr said.
Auburn launches new AI course for business leaders in Birmingham
As AI (artificial intelligence) becomes increasingly integrated into our everyday lives, it's transforming everything from the way we search for information
Mark Consuelos injured during “Live With Kelly and Mark ”break as Kelly Ripa recovered from gum surgery
Consuelos revealed a sports-related injury sustained while “Live” was on a between-season break, during which Ripa was recovering from a painful oral procedure.
'Preposterous.' 6 Washingtonians on how the high cost of living affects their lives
KUOW spoke with six Washingtonians of varying income levels about how the region's high cost of living is affecting them — and potentially how they'll vote this fall.
The New York Times
Seven of Ukraine’s top 10 military contractors won new business despite open criminal investigations for fraud, failures to deliver on earlier deals or the arrest of chief executives for corruption,...
LMH Health announces participation in Astra Health to expand access, improve care and reduce healthcare costs
We are pleased to announce that LMH Health is one of five independent Kansas health systems joining together to form Astra Health, a new regional healthcare collaboration designed to improve patient care, strengthen access to specialty services, and deliver more affordable healthcare options for employers and communities across Kansas. By working together, participating health systems […]
Indian Health Service leaders follow gains from Indiana Federal EHR go-live
Indian Health Service leaders gained valuable insight by observing VA’s Federal Electronic Health Record (EHR) go-live operations in Indiana.
Kelly Ripa returns to ‘Live’ for first time in over 1 month after painful gum surgery
Kelly Ripa finally returned to ‘Live With Kelly and Mark’ for the first time in over a month, following an extended absence due to painful gum surgery.
Academy Sports + Outdoors Announces Participation in Upcoming Investor Conference
Academy Sports + Outdoors (the "Company") (Nasdaq: ASO), a leading full-line sporting goods and outdoor recreation retailer, today announced its participation in the upcoming Goldman Sachs 33rd Annual Global Retailing Conference to be held Monday, September 14 to Tuesday, September 15, 2026. Chief Executive Officer, Steve Lawrence, and Chief Financial Officer, Carl Ford, will participate in a fireside chat that will be webcast live on September 15th, at 11:30 a.m. Eastern Time. The live webcast
Meet a Health Hero Finalist: Lyndsay Hoy
The Penn-affiliated anesthesiologist lives with a rare, progressive lung disease known as lymphangioleiomyomatosis (LAM). Here's how she's working to advance research and support others living with LAM.
WSU receives $2.5 million to expand street medicine training
Doctors in WSU’s internal medicine residency program will learn to care for people experiencing homelessness by meeting them where they live in Everett and Spokane.
The Legacy Business: Estate Management Ensures the Music Never Dies
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The insurgent Democrat taking on David Valadao
The 31-year-old progressive is betting his working-class roots and economic message can energize voters in one of the country’s youngest congressional districts.
📺 Follow Roma’s Champions League journey live on NOW!
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MDI Health to Honor Mount Desert Nursing Association with 2026 Impact Award
BAR HARBOR—MDI Health will honor Mount Desert Nursing Association (MDNA) as its 2026 Community Partner of the Year during the organization’s Annual Meeting and Community Celebration on Tuesday, September 15. MDNA will receive the 2026 Impact Award in recognition of its longstanding commitment to providing in-home nursing, physical and occupational therapy, and medical equipment to the Island region. By caring for people where they live, MDNA helps patients remain safely and independently at home, providing reassurance and support to their families. “Mount Desert Nursing Association exemplifies the power of community partnership,” said Chrissi Maguire, President and CEO of MDI Health. “Its nurses bring skilled, compassionate care directly into people’s homes, helping patients navigate illness, recovery, and some of life’s most difficult moments. We are deeply grateful for MDNA’s service and the important role it plays in the health of our community.” MDNA works closely with MDI Health providers and care teams to support continuity of care following hospitalization, surgery, illness, or changes in health. Its personalized services extend care beyond the hospital and help ensure patients receive the support they need close to home. “For 77 years, MDNA has been here for our community, helping our neighbors recover and remain safely at home. Our long-standing partnership with MDI Health is an important part of making that possible. Together, we help ensure a seamless transition from hospital to home and provide patients with the continued care they need. We are incredibly grateful for this recognition and especially proud of our talented and hardworking team,” said Amy McVety, Executive Director of Mount Desert Nursing Association. The Impact Award will be presented during MDI Health’s Community Celebration from 5 to 7 p.m. at the Bar Harbor Club. The event will also recognize outstanding employees, volunteers, and trustees; celebrate MDI Health’s achievements over the past year; and mark a transition in Board leadership as Madeleine Braun, PhD, MBA, prepares to succeed Martha Wagner, PhD, as chair. The celebration will feature music, refreshments, the MDI Health Auxiliary Raffle, and a cash bar. MDI Health’s Annual Business Meeting will take place from 3:30 to 4 p.m. via Zoom. These events are free and open to the public, but space is limited. To reserve your spot, contact Patrianna Anderson at 207-288-5082, ext. 1432, or visit mdihospital.org/communitycelebration. Subscribe Share Leave a comment
Official: Liverpool Announce Turkish Airlines as New Shirt Sponsor
Standard Chartered had a good run.
Gulf Funding and Gaza’s Political Horizon Hang in the Balance
At Abu Dhabi’s Hili Forum, Nickolay Mladenov delivered […]
WATCH LIVE: Mayor Mamdani holds 9/11-related press conference
The New York City mayor announces the release of more than 170,000 pages of documents related to the air quality around the World Trade Center site in the months after the Sept. 11, 2001 attacks.
76ers, Flyers Unveil First Look at New Arena Designed to Shape the Future of Philadelphia Sports and Entertainment
Scheduled to open in 2030, the arena is designed to deliver a next-generation fan experience and amplify the energy of Philadelphia sports, concerts, live entertainment and community programming.
Business Aviation & AAM Appointments: Royal Aeronautical Society, Cutter Aviation, And More
Lindsey Oliver of BBGA is honored as a Royal Aeronautical Society fellow, while Cutter Aviation and Skyfarer announce key leadership appointments.
Headline Booking Celebrates 15 Years of Creating Extraordinary Live Entertainment Experiences
Entertainment company marks 15 years of connecting private clients, corporations and charitable organizations with world-class headline talent.
Joel Klatt Unloads on Bryce Underwood After Michigan Escape
Joel Klatt delivered a harsh assessment of Bryce Underwood after Michigan’s escape against Western Michigan, saying the QB has regressed.
Publish council changes legal advice, Surrey politicians say
The government says Surrey will not be affected by a review of plans to merge councils in England.
NI education: Pupils' scores in reading and maths fall over last decade
The Programme for International Student Assessment (Pisa) tests are seen as a significant benchmark in how education systems are performing.
Has Arbeloa 'underestimated' the Premier League?
"If you are a Fulham fan, you are worried right now," former Premier League striker Chris Sutton has said after seeing the Cottagers pick up zero points from their first three league games of the season. "I thought Fulham were quite an attractive team under Marco Silva," Sutton said on BBC Radio 5 Live's Monday Night Club.
Tottenham's spending means they 'should be better'
BBC Radio 5 Live's Monday Night Club has been discussing Tottenham's start to the season, with Chris Sutton asking when boss Roberto de Zerbi is going to "take responsibility" for results against a background of the amount of money spent. Spurs are in the bottom three having picked up just one point from their opening three league games, and are yet to score a goal in the competition - though they did put five past Charlton Athletic in the Carabao Cup second round. "I've not seen those comments if he has done, but he's made a fair few excuses so far this season," said former Premier League striker Sutton.
'Arsenal look top'
"I thought Arsenal were fluid last season, but I feel like they are actually more fluid this season," says former England defender Conor Coady. "Arsenal look the most ready I've seen them in a long time at this stage of a season," Coady told BBC Radio 5 Live's Monday Night Club.
Scientists have traced the human eye back to a tiny one-eyed ancestor that lived nearly 600 million years ago — and remnants of that ancient “cyclops” eye may still survive inside our brains as the pineal gland
What if the mysterious gland Descartes thought held the soul is actually a shriveled relic from our one-eyed ancestor—and some animals still use theirs.
Central Ohio's Bird and Byron survived 'AGT' callbacks for live show
Will Blake "Bird" Bergere and Nick "Byron" Lorenz walk away with $1 million and a shot at headlining in Vegas? Tune in to "AGT" at 8 p.m. Sept. 8 on NBC.
Stevie Nicks’ fans praying for her after heartbreaking announcement. Here’s the latest
The singer has yet to comment on the tragic news.
Health Science Saves Lives
Lessons resonate more with students when they can see that what they are learning in class has real, tangible meaning.
Health Science Saves Lives
Lessons resonate more with students when they can see that what they are learning in class has real, tangible meaning.
Datameds, AI., and Tollo Health Partner with the NFL Alumni Association for Health Lives Here National Campaign Rollout
Stock Titan provides an ultra-fast stock market news feed and multiple tools for traders and investors.
Grammy-winning country music star suffers medical emergency, postpones shows
The country music legend's daughter shared the news on social media.
Singer collapses onstage at Ryman, leaving fans stunned, praying: ‘Really unsettling’
The scary scene unfolded at Satuday's show in Nashville.
Maine cancer survivor sharing wellness, health lessons in new app
Tom McGowan of Windham is using what he learned during treatment to help better the lives of people around the world.
NFL QB Legend Kurt Warner Has Blunt Message to Sports Critics
Kurt Warner has seen the pressure that comes with professional football from nearly every possible angle, and the NFL legend recently delivered a blunt message to sports critics. The Hall of Fame quarterback expressed frustration with the growing tendency to attack athletes online as though performing under extraordinary pressure should be effortless. Warner acknowledged that […] The post NFL QB Legend Kurt Warner Has Blunt Message to Sports Critics appeared first on Gridiron Heroics.
‘Pawn Stars’ star Rick Harrison gets major health update after emergency heart surgery
It comes just days after he was rushed into surgery.
‘Pawn Stars’ star Rick Harrison gets major health update after emergency heart surgery
It comes just days after he was rushed into surgery.
Popular musician dies after medical event leads to head-on crash: ‘Never felt any pain’
He was 77-years-old.
Music legend considering leaving the U.S. because of Donald Trump: ‘I’m not aboard’
The eight-time Grammy Award winner made the revelation during a recent interview.
Pop music legend known as ‘The Singing Milkman’ dead at 85
A cause of death has not been reported.
Alonso thought 'outside the box' against Arsenal
BBC Radio 5 Live's Monday Night Club team have been discussing Chelsea boss Xabi Alonso's "brave" and "fascinating" approach to defending Arsenal's corners. The Spaniard suffered his first defeat as Blues manager on Sunday, as Mikel Arteta's side came from behind to earn a 2-1 win at Emirates Stadium. On Sunday, Chelsea employed a tactic of leaving four players upfield for defensive corners, going man for man in the penalty area.