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Ingredion plans global Benicaros prebiotic expansion across gut and immune health applications
Ingredion highlights that its recent acquisition of the Benicaros prebiotic is a strong strategic addition to its Healthful Solutions portfolio, supporting the company’s formulation versatility alongside expansion of health-forward and clean label ingredients. The company purchased the patented prebiotic fiber, made from upcycled carrot pomace, from NutriLeads earlier this month. With the deal, Ingredion obtained full ownership of all intellectual property, trademarks, human clinical trials, and know-how related to manufacturing Benicaros.
Aligning patient and planetary health: planetary health diet adherence and inflammatory bowel disease prognosis across Western and Eastern cohorts
npj Science of Food - Aligning patient and planetary health: planetary health diet adherence and inflammatory bowel disease prognosis across Western and Eastern cohorts
Cedar Crossing Casino to open in 6 months, BBQ restaurant prepares for business boom
CR Midnight Smoker BBQ sits next to the casino construction site. Owner Greg Stoll said business has not slowed during the build.
Bakunawa Killer revealed as a new character for Virtua Fighter Crossroads
The "Bakunawa Killer" as been revealed as a brand new character for Virtua Fighter Crossroads. Based on the dialogue heard in the trailer, it's implied that the Bakunawa Killer will have a heavy influence on the game's story ...
Israeli strikes and shelling in Gaza kill at least 4 Palestinians, health workers say
Local health officials say the latest Israeli strikes across the Gaza Strip have killed at least four Palestinians, including a 13-year-old girl
Efzimfotase alfa demonstrated improvements in bone health in treatment-naïve pediatric patients with hypophosphatasia achieving median difference of 1.67 vs placebo in RGI-C Score at week 25 in MULBERRY Phase III trial
Positive results from the MULBERRY Phase III trial showed that efzimfotase alfa (ALXN1850), an investigational enzyme replacement therapy, demonstrated a statistically significant and clinically meaningful improvement in bone health in children (2 to
Texas Democrats leave convention united in effort to end GOP's 30-year hold on Texas
Texas Democrats spent their 3-day convention in Corpus Christi rallying party activists, training volunteers and making the case for Democratic policies and candidates across the state ahead of the 2026 midterm elections.
Kings’ Acuff Jr., Nets’ Brown Jr. Rivalry Continues in NBA
From high school shootouts to collegiate clashes, these elite lottery picks bring a storied history to the pros as they prepare to ignite a cross-conference professional feud.
Commentary: Putting students before politics
After another school year, superintendents across Texas are not just packing up classrooms; we are staring down spreadsheets, trying to piece together next year’s budgets. It is a grueling annual...
Sarasota Business Awards honor innovation, entrepreneurship and the American spirit
The Greater Sarasota Chamber of Commerce recognized businesses in the community across 10 categories.
Fireball spotted over south Louisiana
A fireball meteor streaked across south Louisiana skies early Sunday, captured on cameras and reported across several southern states.
Meteor streaks across skies, causes bright flash Sunday morning
Early risers across southeast Louisiana were treated to quite a sight on Sunday morning when a brilliant flash of light streaked across the pre-dawn sky. Around 5:00 a.m., Storm Station viewers reported seeing what looked like a large, vibrant green ball with fire trailing behind it followed by a bright flash. When small space rocks (meteoroids) slam into Earth's atmosphere at high speeds, they create the light streaks we call shooting stars
Business People
Northwest Arkansas-based CS Bank has recognized its Chairman of the Board, John Fuller Cross, for reaching 70 years in the banking industry.
Business People
Northwest Arkansas-based CS Bank has recognized its Chairman of the Board, John Fuller Cross, for reaching 70 years in the banking industry.
Business People
Northwest Arkansas-based CS Bank has recognized its Chairman of the Board, John Fuller Cross, for reaching 70 years in the banking industry.
New business brings hat bar experience to Mineral County
Haley Nelson started her business in November 2023 in Lake Havasu City, Arizona. Since moving to Montana, she has remained busy fulfilling online custom orders and shipping hats to customers across the country.
MINNEAPOLIMEDIA PRESENTS | This Weekend in the Twin Cities – Entertainment Guide: June 26 ~ June 28, 2026 Edition
Twin Cities Pride, Breakaway, Broadway, concerts, festivals and family fun headline one of summer's biggest weekends across Minneapolis and Saint Paul.
Maryland Christian Chamber of Commerce blends faith and business as membership grows
Since its launch in March 2026, the Maryland Christian Chamber of Commerce has grown to more than 100 member businesses, hosting networking events, prayer calls and monthly forums. The new organization blends Christian values with business principles to support entrepreneurs and foster a shared sense of purpose across Maryland.
Community baby shower in Landover aims to address disparities, promote healthier lifestyles
This weekend in Prince George’s County, people came together for a community baby shower aimed at promoting healthier lifestyles among Black and Brown families across the DMV. With a lot of energy and laughter in the room, hundreds of people gathered at Prince George’s Sports and Learning Complex in Landover. The free event offered support for expecting mothers and parents…
Chicago faith leaders, businesses rally to collect supplies for Venezuela earthquake victims
In Chicago, pastors and businesses across the city are coordinating efforts to send aid after devastating earthquakes in Venezuela.
Recent rulings show that SCOTUS has ditched reason for politics
'The flurry of 6-3 decisions shows how SCOTUS has become a political body, not the judicial one the founders of our Constitution sorely aspired to,' writes an L.A. Times reader.
New vitamin B12 therapy shows promise against deadly brain cancer
Researchers have identified a vitamin B12–based compound that can cross the blood-brain barrier and home in on glioblastoma tumors. In animal studies, the compound accumulated preferentially in tumor tissue and delivered sustained nitric oxide directly to cancer cells. It also worked synergistically with existing glioblastoma treatments, significantly enhancing their tumor-fighting effects.
After ousting Bill Cassidy, Donald Trump faces fresh test of his sway with GOP voters in Louisiana’s Senate runoff
Louisiana Republican voters already rejected an incumbent senator who was crossways with President Donald Trump. In a primary runoff on Saturday, they’ll decide whether to follow Trump’s lead in choosing a new nominee.
LVMH and Accor's Orient Express sets its sights on new tech billionaire class
Shuttling across the French and Italian Riviera, Orient Express's first giant yacht aims to attract a new class of billionaire.
Days Ahead to Show If Burnham Plays Politics Better Than Starmer
Standing across from Keir Starmer in the Commons chamber this week, opposition leader Kemi Badenoch drew on a particularly violent metaphor for how the Labour Party had ditched him when she conjured up an image of “400 knives stuck in the prime minister’s back.”
City of Covington awards final round of fiscal year 2026 Small Business Incentive program funding
The City of Covington continues its commitment to supporting entrepreneurs, revitalizing commercial corridors, and strengthening neighborhood business districts through the Covington Small Business Incentive Program. The Covington Board of Commissioners has approved the fourth and final round of Fiscal Year 2026 Small Business Incentive Program funding, awarding $28,000 to support four projects across the city....
Businesses across Oahu prepare to close as rising costs strain operations
Community members say the closures are difficult to watch, especially as familiar businesses continue to disappear across the island.
States seek to lower drug prices by targeting the companies that manage them for health plans
Legislators across the U.S. are trying to lower prescription costs by reining in big companies that handle drug coverage for health insurers.
Trump-backed Letlow faces Fleming in Louisiana GOP Senate runoff
President Donald Trump’s choice for U.S. Senate in Louisiana is seeking to secure the GOP nomination and deliver another win for the president in his effort to replace Republicans who crossed him
States seek to lower drug prices by targeting the companies that manage them for health plans
Legislators across the U.S. are trying to lower prescription costs by reining in big companies that handle drug coverage for health insurers.
Our Editors Found 401+ Best Amazon Prime Day Deals Worth Shopping Before the Sale Ends
You have less than 24 hours left to shop deals across categories, and some of them are so good that they’re already selling out.
J. William Fulbright, proponent of cultural exchange, left complex legacy across politics, education
As the Vietnam War heated up, U.S. Sen. J. William Fulbright became uncomfortable with American involvement in the conflict.
J. William Fulbright, proponent of cultural exchange, left complex legacy across politics, education
As the Vietnam War heated up, U.S. Sen. J. William Fulbright became uncomfortable with American involvement in the conflict.
The 5-Question Org Chart Audit I Run Before Scaling AI Across a Business
AI success depends less on the technology and more on the organization behind it. These five questions help leaders identify the structural barriers that prevent AI from delivering real business impact.
$13 million in federal funding to be distributed across West Michigan clinics
More than $13 million in federal funding will be distributed across West Michigan hospital and clinic systems for research projects and healthcare infrastructure.
Axios Live: Health care affordability emerges as a defining issue
Concerns about health care costs are motivating voters across the ideological spectrum
We have an epidemic of political violence in this country: National Review columnist
National Review columnist Caroline Downey discusses growing political violence and criticizes Illinois Gov. J.B. Pritzker for his remarks about the Chicago cross-burning incident.
We have an epidemic of political violence in this country: National Review columnist
National Review columnist Caroline Downey discusses growing political violence and criticizes Illinois Gov. J.B. Pritzker for his remarks about the Chicago cross-burning incident.
THE NEXT GENERATION TAKES THE TRACK: COPACI AND PANAM SPORTS LAUNCH ELITE CYCLING DEVELOPMENT CAMP IN TRINIDAD AND TOBAGO
Young cyclists from across the Caribbean are gathering in Trinidad and Tobago […]
MAI-Code-1-Flash for Copilot Business and Copilot Enterprise
MAI-Code-1-Flash, Microsoft AI’s in-house coding model, is now generally available for GitHub Copilot Business and Copilot Enterprise, building on its recent expansion across Copilot surfaces. Purpose-built for coding and optimized…
Walton Arts Center to host blood drive with free entertainment July 1
The Walton Arts Center will host a blood drive in partnership with the American Red Cross from 10 a.m. until 4 p.m. on Wednesday, July 1. The center will provide live entertainment for blood donors in attendance that day, including performances by cellist Carrington Truehart, and guitarists Ben Harris and William Reyes. SUBSCRIBE: Get our
Nintendo’s Summer Sale Is Now Live and Not Only Includes Discounts on Digital Titles, but Also the Switch 2 Upgrade Pack for Breath of the Wild
Nintendo has launched a new Summer Sale until July 8. Save on select digital titles across Nintendo Switch and Switch 2, alongside a Switch 2 upgrade pack for Zelda: Breath of the Wild.
Air-conditioning becomes political amid sweltering Europe heatwave
Much of western Europe baked under a “heat dome” as temperatures soar. Authorities warn that the extreme conditions could endanger lives across countries, many of which have limited air conditioning, a topic of which has left the people of Paris divided.
Athlete of the Year finalist: Penn Manor standout provided the power for Comets in 3 sports
Anneli Starry didn’t know what she had in Joelle Kroesen. The Penn Manor girls lacrosse coach labeled the then-freshman as a swing — an athlete who is rostered on two
PENN Entertainment (PENN) Just Overtook the 20-Day Moving Average
Should investors be excited or worried when a stock crosses above the 20-day simple moving average?
Six Watauga students graduate from N.C. School of Science & Mathematics
MORGANTON/DURHAM — Six students from Watauga County were part of 470 from all across North Carolina who graduated this year as members of the residential Class of 2026 of the
Cannes Lions Entertainment Awards: Adidas Takes Home Grand Prix for Oasis ‘Original Forever’ Collaboration
The 2026 Cannes Lions International Festival of Creativity recognized the best creative campaigns across entertainment, design and craft categories. Sports apparel and footwear maker Adidas’ tie-up wi...
Cannes Lions Entertainment Awards: Adidas' Oasis Collab Wins Grand Prix
The 2026 Cannes Lions International Festival of Creativity winners across entertainment, design and craft categories were announced. Sports apparel and footwear maker Adidas' tie-up with English band Oasis winning the top prize in the Entertainment Lions category.
Braille is literacy: Rice researchers are reshaping the science of reading
As schools across the country increasingly embrace evidence-based approaches to reading instruction through the science of reading, two Rice researchers are leading an effort to ensure students who learn through braille are not left out of the research shaping literacy education.
Robot startup FieldAI achieves $100M milestone in revenue, contracts
FieldAI says it has crossed $100 million in revenue and contracts by building software for robots to work in mines, construction sites, and factories.
The nation’s cartoonists on the week in politics
Every week political cartoonists throughout the country and across the political spectrum apply their ink-stained skills to capture the foibles, memes, hypocrisies and other head-slapping events in the world of politics. The fruits of these labors are hundreds of cartoons that entertain and enrage readers of all political stripes. Here's an offering of the best of this week's crop, picked fresh off the Toonosphere. Edited by Matt Wuerker.
This Democratic congresswoman almost helped elect a Republican speaker
Rep. Marcy Kaptur (D-Ohio) explains why she contemplated supporting Rep. Kevin McCarthy (R-California) in 2023 with an extremely rare crossover vote.
World Cup brings a boost to bar and restaurant businesses across the Piedmont-Triad
Bars and taprooms across the Piedmont-Triad are extending their hours and providing the ultimate experience as the World Cup enters its second week.
'A heavy impact:' Schwebel's closure leaves a sense of community loss
It’s the small things that residents across the region will remember when Schwebel’s closes its doors at summer’s end. Everything from...
PNC Business Credit Names Brady to Southwest Region Sales Manager
PNC Business Credit promoted Eamonn Brady to Southwest region sales manager. Based in Denver, Brady will spearhead business development efforts across both
MINNEAPOLIMEDIA PRESENTS | This Weekend in the Twin Cities – Entertainment Guide: June 26 ~ June 28, 2026 Edition
Twin Cities weekend features Pride, Breakaway, concerts, festivals, theater, museums and family events across Minneapolis, St. Paul and beyond.
County Invites Youth, Camps To Register For ‘Mind Your Business’ July 7 - Town-Crier Newspaper
Palm Beach County’s Mind Your Business Youth Entrepreneurship Forum returns on July 7, offering a full day of hands-on learning and innovation for young people across the county. Now in its seventh year, the forum is designed to inspire the next generation of creators, problem-solvers and emerging business leaders. Open to youth ages 10 to […]
It's Xbox's turn (again), as console prices keep going up
Microsoft announced a price hike for the Xbox Series consoles today, the third in little over a year. Effective August 1, the Xbox Series S, which launched in 2020 for $300, will cost $500 in the U.S. The Xbox Series X, which launched in 2020 at $500, will go for $800. This follows a round of PlayStation 5 price increases from Sony this spring, and a slow-motion increase for Nintendo’s Switch 2, which will kick in in the U.S. in September. (Mind you, there were also eight video game industry price hikes in six months of 2025). The chart up top shows the sudden ascent of console prices over the past year, a sudden surge in an already unusual hardware generation. Prices had been flat for years, now “up” is the new “flat.” Game console prices used to go down across the length of a console generation, but not this time around. Microsoft’s explanation for the new price hike today: We hoped another price increase would not be necessary, and we have spent the last several months working with suppliers on options. Unfortunately, console storage and memory prices have increased by more than 2.5x and we expect another doubling by the fall of 2027. The entire consumer electronics industry is struggling with the current components crisis, but the effects are particularly hard on consoles. Unlike phones, computers, speakers, and other consumer devices, consoles are typically not sold at a profit, but instead for less than they cost to make. This is an issue well beyond game consoles. Apple announced price hikes on its computers and tablets today as well. Game File is a reader-supported publication. To receive new posts and support my work, consider becoming a free or paid subscriber. Subscribe Item 2: Brutal Bungie cuts Bungie laid off “most” of its Destiny development team and some developers who worked on Marathon, the newest game from the struggling Sony-owned studio. A WARN notice issued by Sony to Washington State, where Bungie is based, tallied cuts impacting 292 workers, effective next month. That’s strictly for Bungie/Sony jobs in Washington and wouldn’t account for any elsewhere. The video I clipped below shows the redacted list of Bungie cuts filed to Washington State officials. As you’ll see, I had to scroll for a while… In a note emailed to PlayStation workers and published online, PlayStation game studios chief Hermen Hulst offered the following explanation for these latest cuts at Bungie: This is painful news, especially for talented colleagues whose roles have been eliminated. This decision was made only after extensive discussion and careful consideration, and I want to provide some context on how we arrived here. Over the past several months, together with Bungie leadership, we reviewed the studio’s long-term direction, development priorities, resource needs, and role within our broader portfolio strategy. We explored multiple alternatives before concluding that a reduction was necessary to align the studio’s resources with its current priorities and long-term goals. In 2022, Sony bought Bungie for $3.7 billion. The studio’s marquee game, the multiplayer live service shooter Destiny 2 was losing popularity at the time. Its next game Marathon, released earlier this year, has been well-reviewed but had a slow start. Bungie is renowned for making great shooter games, and Destiny fans have mourned the wind-down of Destiny 2. They’ve also expressed bewilderment over reports that Destiny 3 is not, per Bloomberg, immediately in the cards.
2026 World Cup Is Putting FIFA’s Rules on Political Neutrality to the Test
The World Cup is in full swing across North America, and the U.S. men’s team faces Turkey in its final group round appearance on Thursday. But behind the cheering fans and nail biting matches, FIFA's commitment to political neutrality is put to the test. Marisa sits down with Tariq Panja, global sports correspondent at The New York Times. They dig into the politics behind the games, from restrictions on Iran’s team and President Trump’s unusually close relationship with FIFA president Giann
Kentucky State hosts students for agriculture and health science camp
Students from across the country are at Kentucky State University for a summer program focused on agriculture, health and environmental science.
Plaucheville business opens parking lot to Red Cross, polling site after flooding
One week after Avoyelles Parish received nearly 30 inches of rain in less than 12 hours, 2 Sisters’ Salsa is opening its parking lot to help the community recover.
Plaucheville business opens parking lot to Red Cross, polling site after flooding
One week after Avoyelles Parish received nearly 30 inches of rain in less than 12 hours, 2 Sisters’ Salsa is opening its parking lot to help the community recover.
M5 Ultra Mac Studio Could Launch in 2026 With Up to 768GB of RAM
Despite price increases across the Mac line, Apple is still planning to release a new Mac Studio as soon as this year, reports Bloomberg. Apple plans to introduce a new M5 Ultra chip as the final option in the M5 family before it transitions to the M6, M7, M7 Pro, and M7 Max. The M5 Ultra will come in a new version of the Mac Studio, which hasn't been updated since March 2025.
FlashPoint: How a Christian political media network became a platform for Indiana’s Lt. Gov.
By Sydney Byerly The Indiana Citizen June 25, 2026 When Indiana Lt. Gov. Micah Beckwith called Islam a “demonic death cult” during an appearance on the Christian political program FlashPoint in May, the remarks drew swift backlash from faith leaders across Indiana. It also highlighted the growing influence of the Christian media network that amplified
Less Islamism, More Nationalism
In Iran and across the Middle East, the bond between religion and politics is getting weaker.
Making Our Own Luck
We are cross-posting a piece that former NIH official Kris Willis wrote for Macroscience. Kris is now the President and Founder of the Woodley Park Institute, for which I’m a board member. Picking winners or hedging bets? Federal science agencies have long wrestled with the question of how to ensure their billions of dollars of grants and contracts result in maximum benefits for Americans. On the surface, it might seem that a goal-oriented, interventionist style of management would be the best policy: prioritize our most pressing problems and distribute funding accordingly.This top-down strategy creates a unique hazard, though: bad choices can send resources in the wrong direction, resulting in slow progress that impedes the delivery of tangible benefits to citizens. Moreover, if decision makers pursue an applied advance when the underlying scientific principles remain poorly understood, they risk costly failures and a loss of support for the research enterprise at large. Examples include Nixon’s 1971 War on Cancer, undertaken on the premise that a cure could be achieved in less than a decade, the drive to build an operational commercial fusion plant by the mid-1990s, and the National Plan to Address Alzheimer’s Disease, which failed to produce the effective treatments and prevention strategies promised by 2025. The contrasting laissez-faire approach is to hedge your bets. If the path to an advance is impossible to predict, then the wisest choice might be to distribute funding to as widely as possible. The main risk of this strategy is that spreading funding thinly may limit the resources available to the most promising research, resulting in the same negative outcomes as the interventionist approach: limited support for the most promising topics, slow progress, and delayed returns. In reality, at science agencies like the National Science Foundation and National Institutes of Health, program managers navigate between these two extremes, setting some funds aside to target high-priority areas and using the rest to cover the widest possible range of meritorious proposals. This middle path seems like the most rational way to proceed, but it still requires making choices. How much should be set aside for high priority topics? What should those topics be? How should we define merit? Expert opinion can provide a helpful guide, but leading experts can have remarkably different opinions about what matters and what should be prioritized. Moreover, experts and administrators alike can be risk averse, giving an edge to high-profile, well-established concepts. What’s really needed is a data-driven framework to help guide decision-making, one that doesn’t simply repackage prestige or incumbency. Recognizing breakthroughs years in advance Many breakthroughs fail to attract funding or recognition at the earliest stages of development. Katalin Karikó, for example, spent years struggling to win grants for work on mRNA that would eventually win her and Drew Weissman a Nobel Prize. Similar stories can be told about Jim Allison’s groundbreaking studies leading to the development of cancer immunotherapy, Stan Pruisner’s demonstration that prions can self-replicate without DNA, or Robin Warren and Barry Marshall’s proof that Helicobacter pylori, not stress, causes ulcers. Yet at some point, the scientific community recognizes and responds to transformative breakthroughs like these. How does that change happen? And what if science funders could identify the areas that are on the cusp of a breakthrough? Those questions led my collaborators and me to study how scientists responded to past breakthroughs. Based on patterns in that data, we developed a means of predicting future breakthroughs, using biomedicine as a proof of concept. It’s worth taking a moment to describe how our approach works. Briefly, our prediction process begins by grouping the 18 million or so peer-reviewed papers in PubMed, the authoritative database of biomedical research, into roughly 50,000 unique topics. A small subset of these topics are so widely acclaimed as breakthroughs that they have been recognized with a major prize like a Nobel or a Lasker Award. We theorized that studying the development of these outliers over time, especially before they gained acclaim, was the key to identifying future instances of them. After defining topics, we chose 21 representative breakthroughs and asked what they looked like before they won prestigious prizes. To answer that question, we re-ran our topic-mapping algorithm repeatedly, winding back the clock one year each time, stringing together the years to follow the progress of each field as it grew and advanced. We found that in each case, the years leading up to a discovery followed a pattern: a burst of papers on a new, rapidly evolving topic, many of which quickly became influential. These characteristics—the percent of papers that are new, the percentage of papers that are brought in from other topics, and the influence of each individual paper—can all be measured separately for any given topic. Together, they act as a predictive signal that is detectable an average of five years before a transformative discovery is made, and up to thirty years before the discovery receives a major prize. Scanning the current research landscape for topics that display this signal allows us to predict what work will likely produce a future breakthrough. Each year we analyzed includes four or five signals, a number that appears to have remained constant across a twenty year time frame. In their classic work on the sociology of science, Bruno Latour and Steve Woolgar established that the desire to participate in a major discovery is an important motivator for scientists as they consider whether they should take up (or abandon) a research problem. Although further work is needed, the simplest explanation for our results is that this behavior is widespread enough to detect at scale. A foundational advance, or something like it, draws the attention of scientists and causes them to change the direction of their research. They vote with their feet, staking their own reputation and careers by publishing on and citing the new idea. That upswell of interest is the foundation of our breakthrough signal. What kind of research does our model identify as a breakthrough? After building a model based on the patterns in our 21 preselected breakthroughs, we tested it by identifying all early signals of discovery from 1994 through 1997. Of the 18 signals we found in that time period, 17 can be traced forward in time to a breakthrough. Examples include super-resolution fluorescence microscopy (see the image above), the directed evolution of proteins and enzymes (Chemistry Nobel, 2018), and sequencing the human genome (National Medal of Science, 2008). The discovery of the role of leptin signaling in obesity is a particularly interesting case study. Around 1950, scientists noticed the existence of a type of lab mouse that suffered from a unique inherited form of obesity. When given the freedom to choose their own diet, these mice ate more than normal and preferred food that was high in fat. Researchers had few clues as to why the animals overate; early experiments pointed to the existence of a soluble ob factor found circulating in the bloodstream that regulated appetite, but its identity was unknown. In 1994, Jeffrey Friedman and colleagues identified and sequenced the ob gene, noting that the protein it encoded appeared to fit the profile of a circulating factor. A year later, a trio of high-profile publications demonstrated that ob was a hormone that regulated body weight and fat deposition by regulating appetite. One of these was co-authored by Friedman, who christened it leptin from the ancient Greek word for thin. Using our model, the data from 1996 make it clear this advance would become a breakthrough. Scientists had flocked to study the biology of the new hormone, generating the flurry of new papers and citations required to produce a signal. One of these demonstrated that serum leptin concentrations reflected the amount of adipose tissue in the human body, providing clinical validation of the earlier mouse studies. Before the identification of leptin, scientists were unable to point to a specific molecule that controlled appetite and adiposity, so that it was impossible to rule out non-physiological causes of obesity; its characterization fundamentally changed our concept of weight gain. In 2010, Friedman and fellow pioneer Douglas Coleman were awarded a Lasker for the discovery. Our work also identifies breakthroughs in clinical practice and behavioral and social sciences, even though these areas are less likely to draw the attention of major prize committees. One example that falls into this category is the introduction of endovascular aneurysm repair, a minimally invasive surgical procedure for the treatment of abdominal aortic aneurysm, a leading cause of death among Americans over the age of 65. Relative to the previous standard of care, it reduces in-hospital mortality by almost four-fold. In 2017, Timothy Chuter received the American College of Surgeons’ prestigious Jacobsen Innovation award for his multiple refinements to the technique. Another under-recognized breakthrough identified by our model is the development of standardized survey instruments to assess the quality of life for HIV+ patients. The antiretroviral cocktails introduced in the mid-1990s reduced AIDS mortality, but treatment came with serious side effects. The new evaluations showed that patients whose disease progressed had worse physical functioning than Americans with other chronic diseases, while those who were asymptomatic maintained a health-related quality of life on par with the overall US population. This evidence made it possible for patients and activists to argue that even in the absence of a total cure, and in spite of the side effects, alleviation of symptoms was a worthwhile priority for clinicians. My colleagues and I have failed to identify any significant recognition for the physicians and health policy experts who pioneered this advance, although in 2016, researchers called for the World Health Organization to set targets for good health-related quality of life as part of its framework to end the AIDS pandemic. From forecasting to funding How should science funders use our predictions? Any serious discussion of what we should do with this new capability needs to begin with an understanding of its limitations. We can’t (and shouldn’t) invest all of our resources in the small number of topics predicted to produce breakthroughs. Innovative new fields are born from existing ones; they rarely arise de novo. If funders don’t maintain a diverse portfolio, the breakthroughs of tomorrow will have no antecedents. Think of this as eating the seed corn, or killing the goose that lays the golden egg. There are also multiple goals of funding beyond basic scientific discovery, including translating discoveries into clinical practice, developing new technologies, supporting economic development, and training new scientists. The investments needed to accomplish these goals are likely different from those required to support emerging breakthroughs. Finally, we must be aware that we may not capture every instance of a breakthrough. The concept is fuzzy, and not every significant discovery is recognized with a major award. Further, breakthroughs are rare, meaning that our dataset is, by necessity, small. This makes formal estimates of accuracy challenging. Although our overall success rate appears to be high, any one signal may turn out to be a false positive. We found one apparent example: the development of the third generation COX-2 inhibitors, Vioxx and Celebrex, which were much celebrated in the early 2000s as effective but non-addictive pain relievers, meets all the algorithmic criteria of a breakthrough. Five years after it received FDA approval, researchers demonstrated that Vioxx was associated with serious cardiovascular complications, and the manufacturer voluntarily pulled the drug from the market. Celebrex remains available, although like other NSAIDs, it carries an FDA warning for increased cardiovascular risk. Decision makers who were overly focused on the breakthrough potential of this research might have wasted substantial resources nurturing an area that ultimately proved to be a failure—but so would those who relied on expert opinion at the time. That said, the potential benefits of funding the next mRNA vaccine or cancer immunotherapy years earlier than we might have are large. When we can’t assume the outcome of an action, it’s worth conducting an experiment. Can targeted support for areas that are poised to produce a breakthrough increase the return on scientific investment without cannibalizing future advances? With the necessary administrative infrastructure in place, conducting this experiment would be straightforward. First, identify all the breakthrough signals between 2018 and 2023, select half at random, and commit to a decade of investment. For biomedicine, a six year window should yield about 30 topics with the potential to produce a breakthrough. Providing strong support to half of these might be accomplished for $300 million a year. That’s roughly half of the recent annual budget of the NIH Common Fund or around 20% of the fiscal year 2025 budget for ARPA-H. After five years, then again at ten, compare to see which group — the one that was actively managed, or the control — produced more breakthroughs, and on what timescale. Although we used biomedicine as an example, the same experiment could just as well be run for physics, materials science, or any other discipline. Any attempt to undertake such an experiment should keep three points top of mind. First, we can predict the topic of future breakthroughs, but the people and vision for how to move the work forward are still important. In practice, this means success requires active program managers with the expertise to develop the science and the authority to do so, including by recruiting investigators. Second, we would be wise to learn from the failures of past attempts to fund transformative research. High among these are funding modestly repackaged work, confusing the genuinely novel with the merely unfamiliar, and relying too much on incumbent investigators. All of these risks can be mitigated by thoroughly and intelligently integrating high quality data into portfolio management. Finally, we need to have patience. Even with strong funding support, producing a breakthrough takes time. If supporting breakthroughs is the best way to nurture the birth of new fields, we also need to accurately describe and properly manage the other two stages, so that we invest wisely throughout the productive lifetime of ideas and divest once they reach the point of diminishing returns. We would benefit from more study of all of these phases, especially the transition from one to another. More research could answer questions like: When does a breakthrough become an established field? How do the availability of funding, the size and characteristics of the available workforce, and the accumulation of evidence that disagrees with prevailing models affect a field’s decline? Exactly how do old ideas give birth to new ones, and can we speed up the process? The more we understand about the dynamics of scientific progress, the better we can maximize the odds that our curiosity leads to results. I’d call that finding a way to make our own luck.
Ohio politicians respond to Supreme Court TPS ruling for Haitians and Syrians
The decision impacts more than 350,000 Haitians and 6,000 Syrians across the country, including many in Ohio.
Cast a Line for Free Across New York June 27–28
New Yorkers will be able to fish for free on June 27 and June 28.
Merck KGaA to Acquire Bio-Techne for $11.3B, Expanding Life Science Tools Presence
Merck KGaA, Darmstadt, Germany, has agreed to acquire Bio-Techne for approximately $11.3 billion, the companies said today, in a deal designed to position the buyer as more of a leader across the life science value chain by expanding its presence in high-growth, next-generation life-sci markets with Bio-Techne’s tools, analytical technologies, and consumables.
Impact of European heat wave on transportation, businesses, tourism
A heat wave across Europe caused record-breaking temperatures, affecting businesses, infrastructure, and daily life.
Adidas’ NIL pipeline is producing NBA rookies who already know the business
Mikel Brown Jr. reached the NBA with a head start few rookies have. Long before being selected sixth overall by the Brooklyn Nets at Tuesday’s NBA Draft, the 20-year-old guard had been embedded in Adidas’ ecosystem through a name, image and likeness deal that began in high school. “By the time our athletes walk across […]
Renewed Dansby Swanson makes Cubs history with 15 RBI across 3 games vs. Mets, including 11 in doubleheader
Following Apple, Microsoft Dramatically Hikes Xbox Prices, Again
Just hours after Apple increased its hardware prices across the board, Microsoft is doing the same with its Xbox consoles. For the third time.
REV Entertainment Announces Enhanced 2027 College Baseball Series Slate
REV Entertainment announces the 2027 College Baseball Series, featuring seven tournaments across five locations. Find full team fields, dates, and additional info here!
Extreme heat and health: Policy guide reveals what communities need to know
Blistering temperatures exacerbated by high humidity are not just uncomfortable but dangerous. Across Canada, and in communities throughout southwestern Ontario, rising temperatures are affecting people's ...
Proposed CDC science office could tighten political control at agency
Under President Trump, political leaders are exerting more control across federal health agencies.
$10 Million Gift to UAB Aims to Improve Rural Health Care Across Alabama
A $10 million gift to the University of Alabama at Birmingham will help train more primary care physicians in rural communities and encourage them to stay and p
An Update from PlayStation Studios
Below is an internal email from Hermen Hulst, CEO, Studio Business Group, Sony Interactive Entertainment distributed today to SIE employees. ********************************************************************************** Dear Team, Today I want to share a difficult update regarding Bungie. We have made the decision to reduce Bungie’s workforce, affecting a significant number of employees, including most of the Destiny team and some Marathon team members. There are also reductions across SIE teams that support […]
Alex Freeman Headlines Kids Of Former NFL Players Making Their Names In Other Sports
Team USA's Alex Freeman is leading the charge of breakout athletes across sports with NFL bloodlines.
Psychedelic Science 2027 Speaker Submission Invites the Field to Bridge Promise and Practice
Psychedelic Science 2027 (PS27) convenes May 3–7, 2027, at the Colorado Convention Center in Denver under the theme “Bridging Promise & Practice”PS27’s speaker submission is now open through Friday, September 18, with no planned extensionsPS27 welcomes proposals across science, therapy, policy, culture, industry, the humanities, spirituality, connected movements, and the wisdom traditions that have carried this work for generations DENVER, June 25, 2026 (GLOBE NEWSWIRE) -- The Multidisciplinary
Scientists Analyzed the Bones of ‘Skeleton Lake.’ What They Found Made No Sense.
Roopkund Lake sits in a frozen pocket of the Himalayas where hundreds of people died across a millennium. So why did researchers find bones from the island of Crete there?
Ensuring health for Special Olympics athletes
University of Minnesota healthcare students across many disciplines are helping to provide health screenings for athletes competing in the 2026 Special Olympics USA Games.
Around the MHS
This edition of news from around the Military Health System for the week of June 22-26, 2026, includes a vital partnership between Offutt Air Force Base and the American Red Cross, new Uniformed Services University research on stress fractures, and Naval Medical Research Unit EURAFCENT participates in a multinational readiness exercise.
Playing soccer can score major goals for heart and brain health
Seattle, June 25, 2026 — As the global soccer championship run by the Fédération Internationale de Football Association (FIFA) plays out on stages across the world this summer, catching a fever for football (as soccer is known outside the U.S.) may...
Keiser's Paul Dodson Voted 2025-26 SUN Sports Information Director of the Year
The Sun Conference is pleased to announce that Keiser University Assistant Athletics Director of Communications Paul Dodson has been named the 2025-26 Sun Conference Sports Information Director of the Year, as voted on by his peers across the league. The honor marks the third conference SID of the Year award of Dodson's career after previously earning the distinction in 2022-23 at Keiser University and 2018-19 while at Johnson & Wales University.
Oakland Athletics Partners with Motion Sports
ROCHESTER, Mich. - Oakland University has announced a new partnership with Motion, the modern technology platform built for college athletic departments. The Golden Grizzlies will implement Motion across their athletic department, giving coaches, academic staff, and student-athletes a cleaner, more connected way to work.
Mamdani's Success in New York Tests Democratic Party's Willingness to Change
NEW YORK (AP) — New York City Mayor Zohran Mamdani stepped into the national spotlight this week as an ascendant political force within the Democratic Party. Democratic leaders aren't so sure that's a good thing. As progressives cheered across the nation, some of the most powerful Democrats in the ...
89 Middle Tennessee nonprofits awarded $2.1M in grants by HCA Healthcare Foundation
A $2.1 million round of grants is headed to dozens of nonprofit organizations across Middle Tennessee.
Candidates backed by Vermont’s Bernie Sanders sweep House primaries in New York City
“The American people — in New York and all across this country — are sick and tired of status quo politics,” the independent U.S. senator said Wednesday.
New Mexico’s plan to rebuild behavioral health creating clashes, confusion in some communities
As officials across New Mexico work to rebuild the state's behavioral health system, some community leaders have requested more time.
Smoky skies prompt health advisories in Colorado’s mountains as wildfires balloon across the West
A haze from out-of-state wildfires is choking the Colorado mountains as widespread drought and persistent hot, dry weather continue to elevate the fire danger. The smoke wafting across the Western Slope is primarily from three...
New Patient Guidebook Helps Puget Sound Beneficiaries Navigate Their Health Care
MADIGAN ARMY MEDICAL CENTER, Joint Base Lewis-McChord, Wash. -- Great news for military communities and TRICARE beneficiaries across the Pacific Northwe...
Pints & Politics with WUNC's Colin Campbell in Pittsboro
To celebrate WUNC's 50th anniversary this year, we're hosting 50 events across North Carolina! Please join us on August 19 at BMC Brewing at The Plant in Pittsboro for Pints & Politics with WUNC Capitol Bureau Chief Colin Campbell! The event kicks off at 6 p.m.We'll chat about all things North Carolina politics, and your first pint will be on BMC Brewing in a special WUNC 50th anniversary pint glass! This event is free and open to the public, but an RSVP is encouraged as space is limited. Please RSVP at the link below to let us know if you are planning to join us. You can also submit a question for Colin in advance when you sign up to attend. We hope to see you soon!> RSVP Here
Colombia's vote may reshape the Amazon's future as political winds shift across Latin America
Abelardo de la Espriella, set to be Colombia’s president, has intensified debate over the future of the Amazon
Colombia's vote may reshape the Amazon's future as political winds shift across Latin America
Abelardo de la Espriella, set to be Colombia's president, has intensified debate over the future of the Amazon.
Online violence against women in politics: what shapes political party responses to technology-facilitated gender-based violence?
Political parties have a primary role to play in tackling online violence against women and gender diverse politicians. While the prevalence and impact of TFGBV, such as coordinated disinformation campaigns, deepfake image-based sexual abuse or trolling are well documented, many parties are still building their knowledge on how to respond effectively and have not put in place internal practices and policies that respond to the rapidly evolving, poorly regulated digital ecosystem. About the ReportIn order to promote and protect fair and democratic participation in politics, this ALIGN Report explores what political parties are doing in response to TFGBV and what factors shape their action. The findings, based on existing literature and interviews with gender and politics professionals, indicate there are three sets of factors which donors, civil society and practitioners should consider when designing action to support political parties to respond to TFGBV internally. These are: (1) gender norms; (2) socio-political environment; and (3) internal party factors.Key messagesUnequal gender norms are ubiquitous across politics, shaping expectations of leaders to be strong and assertive, and practices of political parties to uphold masculinist values and sustain cultures of silence. These often lead to weak response to TFGBV against women politicians.The socio-political context can incentivise or disincentivise action, depending on the salience of gender issues, which are increasingly weaponised. Electoral competitiveness, domestic laws (i.e. quota requirements), and even the political system or global normative frameworks influence political will to act.Internal party factors that shape responses will vary across countries and contexts, but include: structures to enforce codes of conduct, policies and reporting mechanisms on (TF)GBV, political ideology, extent of centralisation of leadership, and crucially the meaningful participation of women in decision-making positions, not least through internal women’s wings.Party responses can be seen as a spectrum, with actions falling between active discouragement to address TFGBV to commitment to transform unequal norms and practices within the party.About the ToolkitTogether with the report, this ALIGN toolkit offers gender professionals and others working on democratic strengthening a set of guiding questions and reflection prompts to identify which responses could be most effective and suitable in different contexts. These actions can complement other solutions to TFGBV, such as regulations promoting safety by design. The assessment spans a broad range of factors including: (1) different manifestations of gender norms, (2) the socio-political environment and (3) internal party structures.Key messagesPolitical parties are duty-bound to take action internally to respond to the significant threats posed to women members and candidates, including from their own party colleagues, affiliates and political peers.Existing party approaches to TFGBV can be assessed along a spectrum which ranges from active discouragement and passive acceptance to minimal response and transformative change.To generate effective and context-appropriate solutions to TFGBV, it is important to consider how gender norms shape leadership expectations and internal party practices, while also analysing the impact of the socio-political environment. While actions to support women to stay safe online are very common, codes of conduct and measures to strengthen women’s voice and power in the parties are proposed as most transformative solutions.
NSF selects five additional teams in National Quantum Virtual Laboratory design competition
The U.S. National Science Foundation has selected five new teams to design experimental quantum technologies, from networks that can ferry fragile quantum information across long distances to sensors…
NSF selects five additional teams in National Quantum Virtual Laboratory design competition
The U.S. National Science Foundation has selected five new teams to design experimental quantum technologies, from networks that can ferry fragile quantum information across long distances to sensors…
Google’s New $100 Speaker Makes a Weak Case for Gemini in the Home
The Google Home Speaker is the first new device of its kind to come from Alphabet Inc. in six years. In that time, Google has reshaped itself as an industry leader in artificial intelligence, with its Gemini platform now ubiquitous across consumer hardware like smartphones and web services like Search, Workspace and YouTube.
Scientists finally explain what your dog's eyes do to your brain - Futura-Sciences
That soft look your dog gives you across the room feels like love, and it turns out that is not just sentimental projection. When you and your dog lock eyes, both of your brains release the same bonding hormone that ties a mother to her newborn. Scientists have measured it,...