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Her next act: Former House speaker announces 'Nancy Pelosi Institute'
Pelosi’s involvement in the NPI is not just in namesake: in the new year, she will co-teach a course on Congress with Professor Eric Schickler
What’s next for 988 LGBTQ+ services?
Private ERs, pulmonary hypertension, and other health news from Morning Rounds
CVC Capital Partners to Buy Ingredients Business Irca From Advent
Irca creates more than 7,000 products and serves customers in more than 100 countries and CVC said it would support the next phase of the company’s growth.
OSU rolls to most lopsided all-sports Bedlam Series win on record
STILLWATER – For the sixth time in the last seven years and for the 11th time in the last 13 years, Oklahoma State has won the all-sports Bedlam Series over ...
My wait for a psychiatric bed in Denver highlights this nation’s overburdened system (Opinion)
Just before my birthday, a Denver doctor placed me on an involuntary 72-hour mental health hold. What came next wasn’t treatment but a drawn-out search for a bed, as the U.S. grapples with a shortage for those in crisis.
At 99, this Pasadena ballet teacher has no plans to stop dancing
Helga Monson de Kansky was once predicted to become ballet's next star. Instead, she chose a life with her family and a career as a dance instructor.
iPhone 18e Won't Get ProMotion Display, Says Leaker
Apple's upcoming iPhone 18e will have the same display refresh rate as the existing iPhone 17e, according to a prominent Chinese leaker. Discussing Apple's product plans for 2027 in a Weibo post, Digital Chat Station claimed that the next generation of Apple's low-cost iPhone will feature the same 60Hz low-temperature polycrystalline silicon (LTPS) TFT panel as the current model.
Framingham Baking Co. workers 'couldn't let it go.' What they did next
Two former Framingham Baking Company kitchen workers have started their own baking business.
Louisiana Sports Betting May 2026: Parlays Drove 77% of Revenue as the World Cup Looms
Louisiana took $318M in May 2026 sports bets, with parlays driving 77% of revenue. State tax jumped 41% to $9.5M under the new 21.5% rate. A World Cup surge is next.
Just hopes agent is 'busy' after World Cup impact
Elijah Just hopes his agent is "busy at the moment" as the New Zealand midfielder hinted at a possible summer exit from Motherwell after impressing at the World Cup. Just only joined Motherwell from Danish club Horsens a year ago and is under contract until next summer, with the Scottish Premiership club having an option of extending that by a further year. "The World Cup has given me added belief and also motivation to keep pushing," Just told the NZ Herald.
BT and Verizon to create new international business in $625mn deal
New 50:50 venture will be milestone in UK group’s strategy of refocusing on its domestic operations
PS6 Hardware Cost Estimated at $900+
The upcoming Sony PlayStation 6 is slated to launch sometime in 2028, and with recent reports claiming that the ongoing RAM crisis likely won't end or ease up much before then, concerns are mounting about the price of next-gen gaming consoles. Those concerns are seemingly justified, with ubiquitous ...
Eagles Fifth Round Pick Being Viewed as Next Brock Purdy
If there's one guy I trust around the NFL, it's Howie Roseman. Roseman, who has continued to prove that he can find talent at a very high level at any given moment, is hopeful that he did so in the NFL Draft once again with his fifth-round pick of Cole Payton.
RedMagic officially confirms global launch of flagship OLED tablet
RedMagic has confirmed the Astra 2 as its next flagship gaming tablet. The device will arrive as the international version of the China-bound RedMagic Gaming Tablet 5 Pro, which is confirmed to feature a 185Hz OLED display and the Snapdragon 8 Elite Gen 5 chipset.
Khalid Robinson takes next step as Warriors' head coach for NBA Summer League
As he enters his 11th season with the Warriors, Khalid Robinson is about to step into a new role as Golden State's NBA Summer League head coach
Cedar Crossing Casino to open in 6 months, BBQ restaurant prepares for business boom
CR Midnight Smoker BBQ sits next to the casino construction site. Owner Greg Stoll said business has not slowed during the build.
About 170,000 people in England expected to die from obesity-linked heart conditions by 2035
British Heart Foundation finds about 45 people a day expected to die over next decade if current trends continue
NBC Announces Plans For Special 'Star-Spangled Sunday'
NBC is having a special "Star-Spangled Sunday" broadcast next weekend. Next Sunday is July 5, 2026. It's a very special Fourth of July weekend this year. It's America's 250th birthday. NBC and Peacock will be airing all 15 MLB games on Sunday, July 5. Two games - Mets-Braves and Padres-Dodgers - ...
Yan Diomande chooses PSG as next destination if he leaves RB Leipzig
Diomande registered 12 goals and nine assists for Leipzig, who he only joined last summer from Spanish side Leganes.
Apple iPhone 18 Pro Release Schedule: Why iOS 27 Signals September Date
The just-released second developer beta of the next iPhone software helps confirm what is likely to happen and when for the next iPhones’ release date.
Commentary: Putting students before politics
After another school year, superintendents across Texas are not just packing up classrooms; we are staring down spreadsheets, trying to piece together next year’s budgets. It is a grueling annual...
Who do Scotland fans want as the next head coach?
The speculation has started, but who do Scotland fans want to replace Steve Clarke?
Linux 7.3 To Introduce DRM "Color Format" Property With AMD GPU Driver Support
While the Linux 7.2 kernel merge window is only ending later today to cap off the feature work on this next version of the Linux kernel, already for the Linux 7.3 kernel cycle later in the year there is one notable feature on the way: the DRM color format property is being introduced and being first supported by the AMDGPU kernel graphics driver.
Democrats Wrestle With Race, Populism and Ideology in Clashes With Lawmakers of Color
WASHINGTON (AP) — After democratic socialist Claire Valdez defeated an establishment-backed candidate in New York's congressional primary last week, her elated supporters quickly turned their attention to a new target. “You're next!” they chanted when an image of House Democratic leader Hakeem ...
The PlayStation 6 Reportedly Already Costs $960 in Materials to Manufacture
The PlayStation 6 reportedly costs $960 to build in materials, suggesting next-gen consoles' prices could be much higher than anticipated.
‘People should wait for real data’: Xbox refutes claims that GTA 6 on PS5 is outselling Xbox 8-to-1
Xbox says it’s “had record orders” for the next Grand Theft Auto…
Progressives look to Colorado as next test of a rising movement
Melat Kiros, a 29-year-old democratic socialist and lawyer, is challenging 15-term Rep. Diana DeGette for a solidly blue seat in Denver, where she and her allies hope voters are ready for change.
Conor Sen: This demographic cliff is reshaping universities. Cities are next
An undergraduate enrollment shortfall at Syracuse University is the latest sign that long-forecast demographic pressures are taking their toll on large and well-known institutions, too. Syracuse laid blame on the
Maryland health insurance rates could rise 13.7% in 2027 under proposal
BALTIMORE — Maryland residents who buy health insurance through the Affordable Care Act marketplace could see higher premiums next year, with insurers requesting an average rate increase of 13.7% for
Report: Rockets have been linked to Lakers' Marcus Smart
The Rockets reportedly have interest in signing Marcus Smart away from the Lakers if he declines his player option for next season.
Robison leaves legacy of building partnerships as he accepts next public health challenge at state level
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Party Favors in Brookline closing after 35 years in business
The owners of Party Favors on Beacon Street said after 35 years that it's time for them to enter the next chapter of their lives.
Indiana Fever vs. Los Angeles Sparks: How to watch Caitlin Clark's next game tonight, time, channel and more
How to watch Caitlin Clark and the Indiana Fever play the Los Angeles Sparks on Saturday.
ABC7 reporter goes viral after declaring she doesn’t want to know anything about Bosnia
An ABC7 Los Angeles reporter has gone viral ahead of the United States’ World Cup round of 32 matchup with Bosnia and Herzegovina next Wednesday in Santa Clara, and not for the right reasons Reporter Abigail Velez, wrapping a live shot from Long Beach following the UMSNT’s group-stage loss to Türkiye, announced proudly that she…
Trump says he’ll nominate former Oklahoma state trooper as ICE director
President Donald Trump announced Saturday that he will nominate Lance Schroyer, a former Oklahoma state trooper and Marine, to be the next director of Immigration and Customs Enforcement.
Biggest offseason question for every West team: Big moves for Lakers, Warriors? Can Spurs trade De'Aaron Fox?
Will LeBron James stay in Los Angeles? What's next for Ja Morant and Kawhi Leonard?
When will Los Angeles host the NFL draft next?
L.A. last hosted the draft in 1956, splitting time with Philadelphia
The war for Burnham’s ear: politicians and wonks fight for influence over a PM
There is high emotion, a deluge of policy papers and an ‘excruciating’ jostle for jobs as Labour’s probable next leader settles back into Westminster life
NHL Rumors: 3 Red Wings Who Could Be Traded Next
The Detroit Red Wings made a notable trade on Friday, as they traded top goalie prospect Sebastian Cossa to the Utah Mammoth in exchange for the 23rd overall pick of the NHL Entry Draft. The Red Wings then used that pick to select forward J.P. Hurlbert.Seeing Cossa get traded by the Red Wings is not […] The post NHL Rumors: 3 Red Wings Who Could Be Traded Next appeared first on HEAVY.
Colts roster preview: AJ Haulcy garnering attention during offseason
With training camp off in the distance, we will be previewing each player on the Colts' 90-man roster. Up next is S AJ Haulcy.
How Trump’s takeover fractured America’s birthday party
When Next250 organizers began planning for America’s 250th birthday, they envisioned bringing together communities in a polarized country to celebrate democracy.
Malachi Moreno: “Next year is my year”
Big expectations surrounds Kentucky’s second-year, homegrown center.
Key Colts Playmaker Set to Boost Value in Free Agency?
Indianapolis Colts wide receiver Josh Downs' value could increase greatly between now and next offseason.
Apple A20 Pro motherboard leak hints at notable memory and packaging upgrades
A leaked package layout of Apple's A20 Pro hints at several notable upgrades for the iPhone 18 Pro series. The next-gen SoC is said to feature a wider 96-bit memory interface, a redesigned packaging approach for improved thermals, and a larger Neural Processing Unit (NPU).
Stenberg Excited To Join Sharks, Believes He’s NHL-Ready
Ivar Stenberg says he is ready to be in the NHL next season. After being drafted No. 2 overall by the San Jose Sharks, he becomes yet another another big-name, highly-skilled player in their under-23 group. “They have something really good going on, so super happy to join a special group,” Stenberg said. The 5-foot-11 […] The post Stenberg Excited To Join Sharks, Believes He’s NHL-Ready appeared first on San Jose Hockey Now.
Cardinals' Dustin May: Next start getting skipped
Cardinals' Dustin May: Next start getting skipped
We've Got Our First Look at Every Galaxy Watch 9 Band Before Unpacked
Samsung is preparing to announce its new smartwatch next month, the Galaxy Watch 9. Which we are also expecting to come with the Galaxy Watch Ultra 2
4 AI Prompts to Build a Profitable One-Person Business in 2026 (The Part Every AI Influencer Skips)
Spot the one move every AI influencer skips — and turn it into your next multimillion-dollar business.
Falcons Roundtable: Kyle Pitts Extension Done, Is Bijan Robinson Next?
The Falcons continue to lock up the core of their roster for the future. This week's Falcons Roundtable breaks down Kyle Pitts' new extension, whether his deal or Drake London's is the better value, and why Bijan Robinson appears to be the next superstar in line for a record-setting contract.
What if the economy gets better and it doesn’t help the GOP?: From the Politics Desk
Plus, Gavin Newsom’s next move in the billionaire tax fight.
iPhone 18: Everything We Know About Apple's Biggest Updates
Rumors about Apple's next flagship phones point to a new foldable, a variable-aperture camera, improved battery life and, yes, higher prices.
See inside Kemba Walker's new youth sports hub
The former Charlotte Hornets star says the academy is about creating opportunities for the next generation of athletes.
Texas Tech's Red Raider Meats Has Steak Down to a Science
The Lubbock university is training the next generation of agriculture scientists using revenue from selling some of the state's best beef
Phase 2 of restoration project underway at West Herr Performing Arts Center
Members of the Rochester Broadway Theatre League say this next phase of work includes expanding the theatre's Rothschild Lounge back to its original size.
THE NEXT GENERATION TAKES THE TRACK: COPACI AND PANAM SPORTS LAUNCH ELITE CYCLING DEVELOPMENT CAMP IN TRINIDAD AND TOBAGO
Young cyclists from across the Caribbean are gathering in Trinidad and Tobago […]
Biggest offseason question for every East team: Will Knicks duck second apron? What's next for Celtics, Heat?
Can New York keep its championship roster together? What will Boston do with Jaylen Brown?
Final Countdown: Save Up to 44% On These Prime Day Smartphone Deals by Samsung, Google, Motorola, and More
Need a new Pixel, Galaxy, or Razr? Hurry and grab your next flagship, foldable, or flip phone for a fraction of the price while these Prime Day smartphone deals last!
Apple's OLED 'MacBook Ultra' Will Stick With M5 Pro and M5 Max Chips
Apple's upcoming high-end MacBook model featuring an OLED touchscreen display will use the company's current M5 Pro and M5 Max chips, according to Bloomberg's Mark Gurman. The new, top-of-the-line device will launch "between late this year and early next year," Gurman said, adopting the existing high-end Apple silicon chips rather than next-generation M6 versions.
Apple’s Touch MacBook to Use M5 Pro and Max Chips, With M7 Models to Follow
Apple Inc.’s first-ever touch-screen laptop will rely on the company’s current high-end M5 chips, rather than next-generation silicon, though the company is working on a follow-up model with future M7 processors.
Climbing gym planned in former Summerlin-area movie theater
The gym, which will fill the old Regal Theater on 9400 W. Sahara Ave. in Summerlin, is set to open later this year or early next.
Past participants are now the leaders of MIT’s dynaMIT Club
The MIT student club dynaMIT teaches STEM principles to local middle school students for free every summer. They use fun, innovative experiments to inspire the next generation of scientists and engineers.
Volkswagen reportedly planning to axe 100,000 jobs
Volkswagen, one of the world’s largest automakers, is reportedly planning to axe as many as 100,000 jobs over the next few years, representing 15% of its global workforce.
Sweden and WHO launch new long-term initiative to transform Ukraine’s health system
WHO and the Swedish International Development Cooperation Agency (Sida) have launched a new multi-year cooperation project to support the long-term recovery and transformation of Ukraine’s health system. The new project, “Ukraine’s Health System Transformation Initiative: Strengthening Health Governance, Health Financing and Service Delivery for Long-Term Recovery”, was launched at the Ukraine Recovery Conference 2026 in Gdansk, Poland on 26 June, and will run from June 2026 to 2029. Sweden will contribute approximately US$ 26 million (240 million Swedish krona) to support this project. This contribution forms part of Sweden’s broader support to Ukraine through the Team Europe approach, which brings together the European Union, its Member States, and key partners such as the European Commission’s Directorate-General for Enlargement and Eastern Neighbourhood and Enabel, and WHO as lead health agency, to support Ukraine’s recovery, reform agenda and European integration.“Ukraine’s health recovery cannot be measured only by what is rebuilt, but by whether people can count on the health system when they need it most. The scale of the task is immense, with health reconstruction and modernization needs estimated at US$ 19.4 billion over the next decade. Sweden’s US$ 26 million contribution to Ukraine’s Health System Transformation Initiative is a timely investment in the institutions, financing and services that will support Ukraine’s long-term recovery and European integration. WHO remains a trusted partner of the Government of Ukraine in advancing this process. I am deeply grateful to Sweden for its consistent support and partnership,” said Dr Hans Henri P. Kluge, WHO Regional Director for Europe. More than 4 years of war have placed unprecedented pressure on Ukraine’s health system, creating 3 interconnected challenges. The first is responding to the immediate consequences of the war and the urgent health needs of the population. The second is recovering and modernizing health services today. The third is continuing reforms and aligning the health system with European standards in the context of Ukraine’s future accession to the European Union. The war has led to large-scale population displacement, an increasing need for trauma care and rehabilitation, and shortages of health workers. High out-of-pocket payments in Ukraine make access to health services more difficult. Around 46% of total health expenditure is paid directly by individuals, placing a significant financial burden on many households and underscoring the need for reforms in health financing. Older people, persons with disabilities, women, children and veterans continue to face the greatest difficulties in accessing health services. “Ukraine is demonstrating that health system transformation can continue even during war. Ukraine is also continuing to align its health system with European norms and standards. WHO is committed to supporting Ukraine on this journey. We provide technical support, help coordinate partners’ efforts and support the institutional changes needed to strengthen the system. We are grateful to Sweden for its support. Through this partnership, we can help Ukraine build a more resilient, accessible and people-centred health system,” said Dr Jarno Habicht, WHO Representative in Ukraine. About the Health System Transformation InitiativeThe new initiative will support Ukraine through 3 interconnected areas: strengthening governance and coordination of health sector reforms through more inclusive coordination platforms and structured policy dialogue; transforming service delivery by reinforcing a primary health care-centred model that integrates family medicine, nursing and midwifery; and improving financial sustainability by supporting reforms that ensure the long-term viability of the national health system and reduce out-of-pocket payments for households. Overall, these reforms are expected to make the health system more coherent and easier to navigate, improve the quality and continuity of care, and ensure more equitable access to services, particularly for those who need them most. They will also support Ukraine’s progress towards a more modern health system aligned with European standards. “We are convinced that long-term recovery is not possible without strong, high-quality, person-centred health services that are accessible to everyone. Our partnership with WHO is designed to support deep and lasting systemic changes. Investments in human capital especially autonomous midwives, whose role for maternal, newborn and adolescent sexual and reproductive health cannot be understated, stronger governance, digital transformation and the financial sustainability of the health system are investments in Ukraine’s future. We are proud to support this process,” said Malin Perhult, the Head of the Ukraine Unit at Sida. Focus throughout implementation will be given to the most vulnerable population groups, including older people, women and children, and persons with disabilities, who have been affected by the war and face greater health-care needs. The initiative will be implemented in close cooperation with the Ministry of Health of Ukraine, the National Health Service of Ukraine, the Public Health Centre of Ukraine, regional authorities and international partners. This project will help Ukraine move towards a system where everyone can access the health care they need. It will strengthen primary care, make the health finance system more stable and predictable, and reduce the out-of-pocket costs that Ukrainians face when using health services. As a result, the Ukrainian health system will become more aligned with European standards and more sustainable in the long run.
Emily Wilcox Named Assistant Athletic Director for Sports Communications
Emily Wilcox has been named Assistant Athletic Director for Sports Communications. Her first day is slated for July 13.
College Sports Communicators Recognize Strelow with Writing Awards
BOONE, N.C. — App State's award-winning strategic communications staff added more honors this spring, as Bret Strelow was recognized for two stories in the Fred Stabley Sr. Writing Contest that's conducted by the College Sports Communicators organization.
Sam Fuld, player-turned-business exec, is a new Wharton grad. Up next: The Phillies’ future.
Last month, Fuld graduated from Penn's Wharton School and formally assumed his new role as the Phillies' president of business operations.
In governor's race, voters face stark choice on immigrant healthcare
California’s next governor will face tough decisions on a highly controversial piece of healthcare policy: what to do about health coverage for the more than 1.4 million low-income residents without legal status.
What could be next for Gakpo?
Following the departure of Mohamed Salah, at least one more attacking signing is expected at Anfield this summer. Liverpool have already signed Victor Munoz from Osasuna for £34.5m and the pursuit of Yan Diomande is heating up. Talented teenager Rio Ngumoha is also set to play a more prominent role, while Florian Wirtz played off the left for Liverpool at times last season and is featuring there for Germany in the World Cup.
Clippers draft pick Narcisse Ngoy announces he will play at Auburn next year in unique draft-and-stash situation
County Invites Youth, Camps To Register For ‘Mind Your Business’ July 7 - Town-Crier Newspaper
Palm Beach County’s Mind Your Business Youth Entrepreneurship Forum returns on July 7, offering a full day of hands-on learning and innovation for young people across the county. Now in its seventh year, the forum is designed to inspire the next generation of creators, problem-solvers and emerging business leaders. Open to youth ages 10 to […]
Court battle plays out over Wimbledon tennis expansion plan
A clash over the future of the Wimbledon tennis championships is being played out away from the manicured southwest London courts set to welcome the world's best players next week. Previously home to Wimbledon Park Golf Club, the AELTC wants to build 38 new tennis courts and an 8,000-seat stadium there.
It's Xbox's turn (again), as console prices keep going up
Microsoft announced a price hike for the Xbox Series consoles today, the third in little over a year. Effective August 1, the Xbox Series S, which launched in 2020 for $300, will cost $500 in the U.S. The Xbox Series X, which launched in 2020 at $500, will go for $800. This follows a round of PlayStation 5 price increases from Sony this spring, and a slow-motion increase for Nintendo’s Switch 2, which will kick in in the U.S. in September. (Mind you, there were also eight video game industry price hikes in six months of 2025). The chart up top shows the sudden ascent of console prices over the past year, a sudden surge in an already unusual hardware generation. Prices had been flat for years, now “up” is the new “flat.” Game console prices used to go down across the length of a console generation, but not this time around. Microsoft’s explanation for the new price hike today: We hoped another price increase would not be necessary, and we have spent the last several months working with suppliers on options. Unfortunately, console storage and memory prices have increased by more than 2.5x and we expect another doubling by the fall of 2027. The entire consumer electronics industry is struggling with the current components crisis, but the effects are particularly hard on consoles. Unlike phones, computers, speakers, and other consumer devices, consoles are typically not sold at a profit, but instead for less than they cost to make. This is an issue well beyond game consoles. Apple announced price hikes on its computers and tablets today as well. Game File is a reader-supported publication. To receive new posts and support my work, consider becoming a free or paid subscriber. Subscribe Item 2: Brutal Bungie cuts Bungie laid off “most” of its Destiny development team and some developers who worked on Marathon, the newest game from the struggling Sony-owned studio. A WARN notice issued by Sony to Washington State, where Bungie is based, tallied cuts impacting 292 workers, effective next month. That’s strictly for Bungie/Sony jobs in Washington and wouldn’t account for any elsewhere. The video I clipped below shows the redacted list of Bungie cuts filed to Washington State officials. As you’ll see, I had to scroll for a while… In a note emailed to PlayStation workers and published online, PlayStation game studios chief Hermen Hulst offered the following explanation for these latest cuts at Bungie: This is painful news, especially for talented colleagues whose roles have been eliminated. This decision was made only after extensive discussion and careful consideration, and I want to provide some context on how we arrived here. Over the past several months, together with Bungie leadership, we reviewed the studio’s long-term direction, development priorities, resource needs, and role within our broader portfolio strategy. We explored multiple alternatives before concluding that a reduction was necessary to align the studio’s resources with its current priorities and long-term goals. In 2022, Sony bought Bungie for $3.7 billion. The studio’s marquee game, the multiplayer live service shooter Destiny 2 was losing popularity at the time. Its next game Marathon, released earlier this year, has been well-reviewed but had a slow start. Bungie is renowned for making great shooter games, and Destiny fans have mourned the wind-down of Destiny 2. They’ve also expressed bewilderment over reports that Destiny 3 is not, per Bloomberg, immediately in the cards.
The Week in Business: D'Amico Hospitality's Next Chapter
This week’s top stories from Twin Cities Business.
Jimmy Butler shares ACL rehab update, expectations for Warriors next season
Jimmy Butler shared an encouraging update on his ACL injury rehab and his expectations for the Golden State Warriors in the 2026-27 NBA season.
Scientists develop predictive roadmap to boost performance in next-gen spintronics
Chiral 2D metal halide perovskites (MHPs) are among the most promising materials for future technologies that exploit the spin of electrons in spin-based optoelectronics, or spintronics, but getting them ...
Making Our Own Luck
We are cross-posting a piece that former NIH official Kris Willis wrote for Macroscience. Kris is now the President and Founder of the Woodley Park Institute, for which I’m a board member. Picking winners or hedging bets? Federal science agencies have long wrestled with the question of how to ensure their billions of dollars of grants and contracts result in maximum benefits for Americans. On the surface, it might seem that a goal-oriented, interventionist style of management would be the best policy: prioritize our most pressing problems and distribute funding accordingly.This top-down strategy creates a unique hazard, though: bad choices can send resources in the wrong direction, resulting in slow progress that impedes the delivery of tangible benefits to citizens. Moreover, if decision makers pursue an applied advance when the underlying scientific principles remain poorly understood, they risk costly failures and a loss of support for the research enterprise at large. Examples include Nixon’s 1971 War on Cancer, undertaken on the premise that a cure could be achieved in less than a decade, the drive to build an operational commercial fusion plant by the mid-1990s, and the National Plan to Address Alzheimer’s Disease, which failed to produce the effective treatments and prevention strategies promised by 2025. The contrasting laissez-faire approach is to hedge your bets. If the path to an advance is impossible to predict, then the wisest choice might be to distribute funding to as widely as possible. The main risk of this strategy is that spreading funding thinly may limit the resources available to the most promising research, resulting in the same negative outcomes as the interventionist approach: limited support for the most promising topics, slow progress, and delayed returns. In reality, at science agencies like the National Science Foundation and National Institutes of Health, program managers navigate between these two extremes, setting some funds aside to target high-priority areas and using the rest to cover the widest possible range of meritorious proposals. This middle path seems like the most rational way to proceed, but it still requires making choices. How much should be set aside for high priority topics? What should those topics be? How should we define merit? Expert opinion can provide a helpful guide, but leading experts can have remarkably different opinions about what matters and what should be prioritized. Moreover, experts and administrators alike can be risk averse, giving an edge to high-profile, well-established concepts. What’s really needed is a data-driven framework to help guide decision-making, one that doesn’t simply repackage prestige or incumbency. Recognizing breakthroughs years in advance Many breakthroughs fail to attract funding or recognition at the earliest stages of development. Katalin Karikó, for example, spent years struggling to win grants for work on mRNA that would eventually win her and Drew Weissman a Nobel Prize. Similar stories can be told about Jim Allison’s groundbreaking studies leading to the development of cancer immunotherapy, Stan Pruisner’s demonstration that prions can self-replicate without DNA, or Robin Warren and Barry Marshall’s proof that Helicobacter pylori, not stress, causes ulcers. Yet at some point, the scientific community recognizes and responds to transformative breakthroughs like these. How does that change happen? And what if science funders could identify the areas that are on the cusp of a breakthrough? Those questions led my collaborators and me to study how scientists responded to past breakthroughs. Based on patterns in that data, we developed a means of predicting future breakthroughs, using biomedicine as a proof of concept. It’s worth taking a moment to describe how our approach works. Briefly, our prediction process begins by grouping the 18 million or so peer-reviewed papers in PubMed, the authoritative database of biomedical research, into roughly 50,000 unique topics. A small subset of these topics are so widely acclaimed as breakthroughs that they have been recognized with a major prize like a Nobel or a Lasker Award. We theorized that studying the development of these outliers over time, especially before they gained acclaim, was the key to identifying future instances of them. After defining topics, we chose 21 representative breakthroughs and asked what they looked like before they won prestigious prizes. To answer that question, we re-ran our topic-mapping algorithm repeatedly, winding back the clock one year each time, stringing together the years to follow the progress of each field as it grew and advanced. We found that in each case, the years leading up to a discovery followed a pattern: a burst of papers on a new, rapidly evolving topic, many of which quickly became influential. These characteristics—the percent of papers that are new, the percentage of papers that are brought in from other topics, and the influence of each individual paper—can all be measured separately for any given topic. Together, they act as a predictive signal that is detectable an average of five years before a transformative discovery is made, and up to thirty years before the discovery receives a major prize. Scanning the current research landscape for topics that display this signal allows us to predict what work will likely produce a future breakthrough. Each year we analyzed includes four or five signals, a number that appears to have remained constant across a twenty year time frame. In their classic work on the sociology of science, Bruno Latour and Steve Woolgar established that the desire to participate in a major discovery is an important motivator for scientists as they consider whether they should take up (or abandon) a research problem. Although further work is needed, the simplest explanation for our results is that this behavior is widespread enough to detect at scale. A foundational advance, or something like it, draws the attention of scientists and causes them to change the direction of their research. They vote with their feet, staking their own reputation and careers by publishing on and citing the new idea. That upswell of interest is the foundation of our breakthrough signal. What kind of research does our model identify as a breakthrough? After building a model based on the patterns in our 21 preselected breakthroughs, we tested it by identifying all early signals of discovery from 1994 through 1997. Of the 18 signals we found in that time period, 17 can be traced forward in time to a breakthrough. Examples include super-resolution fluorescence microscopy (see the image above), the directed evolution of proteins and enzymes (Chemistry Nobel, 2018), and sequencing the human genome (National Medal of Science, 2008). The discovery of the role of leptin signaling in obesity is a particularly interesting case study. Around 1950, scientists noticed the existence of a type of lab mouse that suffered from a unique inherited form of obesity. When given the freedom to choose their own diet, these mice ate more than normal and preferred food that was high in fat. Researchers had few clues as to why the animals overate; early experiments pointed to the existence of a soluble ob factor found circulating in the bloodstream that regulated appetite, but its identity was unknown. In 1994, Jeffrey Friedman and colleagues identified and sequenced the ob gene, noting that the protein it encoded appeared to fit the profile of a circulating factor. A year later, a trio of high-profile publications demonstrated that ob was a hormone that regulated body weight and fat deposition by regulating appetite. One of these was co-authored by Friedman, who christened it leptin from the ancient Greek word for thin. Using our model, the data from 1996 make it clear this advance would become a breakthrough. Scientists had flocked to study the biology of the new hormone, generating the flurry of new papers and citations required to produce a signal. One of these demonstrated that serum leptin concentrations reflected the amount of adipose tissue in the human body, providing clinical validation of the earlier mouse studies. Before the identification of leptin, scientists were unable to point to a specific molecule that controlled appetite and adiposity, so that it was impossible to rule out non-physiological causes of obesity; its characterization fundamentally changed our concept of weight gain. In 2010, Friedman and fellow pioneer Douglas Coleman were awarded a Lasker for the discovery. Our work also identifies breakthroughs in clinical practice and behavioral and social sciences, even though these areas are less likely to draw the attention of major prize committees. One example that falls into this category is the introduction of endovascular aneurysm repair, a minimally invasive surgical procedure for the treatment of abdominal aortic aneurysm, a leading cause of death among Americans over the age of 65. Relative to the previous standard of care, it reduces in-hospital mortality by almost four-fold. In 2017, Timothy Chuter received the American College of Surgeons’ prestigious Jacobsen Innovation award for his multiple refinements to the technique. Another under-recognized breakthrough identified by our model is the development of standardized survey instruments to assess the quality of life for HIV+ patients. The antiretroviral cocktails introduced in the mid-1990s reduced AIDS mortality, but treatment came with serious side effects. The new evaluations showed that patients whose disease progressed had worse physical functioning than Americans with other chronic diseases, while those who were asymptomatic maintained a health-related quality of life on par with the overall US population. This evidence made it possible for patients and activists to argue that even in the absence of a total cure, and in spite of the side effects, alleviation of symptoms was a worthwhile priority for clinicians. My colleagues and I have failed to identify any significant recognition for the physicians and health policy experts who pioneered this advance, although in 2016, researchers called for the World Health Organization to set targets for good health-related quality of life as part of its framework to end the AIDS pandemic. From forecasting to funding How should science funders use our predictions? Any serious discussion of what we should do with this new capability needs to begin with an understanding of its limitations. We can’t (and shouldn’t) invest all of our resources in the small number of topics predicted to produce breakthroughs. Innovative new fields are born from existing ones; they rarely arise de novo. If funders don’t maintain a diverse portfolio, the breakthroughs of tomorrow will have no antecedents. Think of this as eating the seed corn, or killing the goose that lays the golden egg. There are also multiple goals of funding beyond basic scientific discovery, including translating discoveries into clinical practice, developing new technologies, supporting economic development, and training new scientists. The investments needed to accomplish these goals are likely different from those required to support emerging breakthroughs. Finally, we must be aware that we may not capture every instance of a breakthrough. The concept is fuzzy, and not every significant discovery is recognized with a major award. Further, breakthroughs are rare, meaning that our dataset is, by necessity, small. This makes formal estimates of accuracy challenging. Although our overall success rate appears to be high, any one signal may turn out to be a false positive. We found one apparent example: the development of the third generation COX-2 inhibitors, Vioxx and Celebrex, which were much celebrated in the early 2000s as effective but non-addictive pain relievers, meets all the algorithmic criteria of a breakthrough. Five years after it received FDA approval, researchers demonstrated that Vioxx was associated with serious cardiovascular complications, and the manufacturer voluntarily pulled the drug from the market. Celebrex remains available, although like other NSAIDs, it carries an FDA warning for increased cardiovascular risk. Decision makers who were overly focused on the breakthrough potential of this research might have wasted substantial resources nurturing an area that ultimately proved to be a failure—but so would those who relied on expert opinion at the time. That said, the potential benefits of funding the next mRNA vaccine or cancer immunotherapy years earlier than we might have are large. When we can’t assume the outcome of an action, it’s worth conducting an experiment. Can targeted support for areas that are poised to produce a breakthrough increase the return on scientific investment without cannibalizing future advances? With the necessary administrative infrastructure in place, conducting this experiment would be straightforward. First, identify all the breakthrough signals between 2018 and 2023, select half at random, and commit to a decade of investment. For biomedicine, a six year window should yield about 30 topics with the potential to produce a breakthrough. Providing strong support to half of these might be accomplished for $300 million a year. That’s roughly half of the recent annual budget of the NIH Common Fund or around 20% of the fiscal year 2025 budget for ARPA-H. After five years, then again at ten, compare to see which group — the one that was actively managed, or the control — produced more breakthroughs, and on what timescale. Although we used biomedicine as an example, the same experiment could just as well be run for physics, materials science, or any other discipline. Any attempt to undertake such an experiment should keep three points top of mind. First, we can predict the topic of future breakthroughs, but the people and vision for how to move the work forward are still important. In practice, this means success requires active program managers with the expertise to develop the science and the authority to do so, including by recruiting investigators. Second, we would be wise to learn from the failures of past attempts to fund transformative research. High among these are funding modestly repackaged work, confusing the genuinely novel with the merely unfamiliar, and relying too much on incumbent investigators. All of these risks can be mitigated by thoroughly and intelligently integrating high quality data into portfolio management. Finally, we need to have patience. Even with strong funding support, producing a breakthrough takes time. If supporting breakthroughs is the best way to nurture the birth of new fields, we also need to accurately describe and properly manage the other two stages, so that we invest wisely throughout the productive lifetime of ideas and divest once they reach the point of diminishing returns. We would benefit from more study of all of these phases, especially the transition from one to another. More research could answer questions like: When does a breakthrough become an established field? How do the availability of funding, the size and characteristics of the available workforce, and the accumulation of evidence that disagrees with prevailing models affect a field’s decline? Exactly how do old ideas give birth to new ones, and can we speed up the process? The more we understand about the dynamics of scientific progress, the better we can maximize the odds that our curiosity leads to results. I’d call that finding a way to make our own luck.
Colts roster preview: Can Riley Leonard secure backup QB role?
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Entrepreneurs pitched business ideas to Yahoo Finance
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Merck KGaA to Acquire Bio-Techne for $11.3B, Expanding Life Science Tools Presence
Merck KGaA, Darmstadt, Germany, has agreed to acquire Bio-Techne for approximately $11.3 billion, the companies said today, in a deal designed to position the buyer as more of a leader across the life science value chain by expanding its presence in high-growth, next-generation life-sci markets with Bio-Techne’s tools, analytical technologies, and consumables.
Apple to Skip High-End M6 Mac Chips in Favor of AI-Focused M7 Line
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Democratic socialists cemented power in New York. Next, the rest of the country?
The wins would not have been possible without significant support from Black and Latino voters who favored them over establishment candidates.
Comcast's Sky Reaches Terms to Acquire ITV's Media & Entertainment Unit for $2 Billion
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Comcast’s Sky Reaches Terms to Acquire ITV’s Media & Entertainment Unit for $2 Billion
The deal, which includes ITV's linear channels and ITVX streaming platform, could be announced in the next two weeks, according to Reuters
New Health Sciences Provost Named
Wake Tech Community College is pleased to announce that Dr. Jennifer Bray has been selected as the next Provost of the Perry Health Sciences Campus.
Another look at carrots and eyesight; how to get more fiber; why mosquitoes bite some people and not others; plus other stories with Vanderbilt Health sources
AARP reporter Stacey Colino interviewed Milam Brantley, MD, Associate Professor of Ophthalmology and Visual Sciences, in 2020 for a story about whether eating carrots can improve vision. Sacramento Bee reporter Samantha Agate has now used Brantley’s comments in an AI-curated story created by content specialists on the same topic that has been picked up by MSN and others. Prevention magazine interviewed Heidi Silver, RD, PhD, Founding Director of the Vanderbilt Diet, Body Composition, and Human Metabolism Core, for a story about the importance of fiber and how people can get more of it in their diet. William Schaffner, MD, Professor of Preventive Medicine, was quoted by several news outlets about public health issues, including: Women’s Health (tick bites and alpha-gal syndrome); The Washington Post (tetanus); and Healthline (why mosquitoes prefer to bite some people and leave others alone). A visit to Monroe Carell Jr. Children’s Hospital at Vanderbilt by some Banana Ball baseball players was covered by The Tennessean and WZTV Fox 17 News, and The Tennessean’s story was also picked up by Yahoo! Sports. Clarksville Now published a story written by the Montgomery County Economic Development Team, whointerviewed Bradley Stancombe, MD, professor of Clinical Pediatrics, Vanderbilt Neonatology, about the new energy of Vanderbilt Clarksville Hospital and how the facility is recruiting physicians. Healio Allergy/Asthma group editorial director Richard Gawel interviewed Mark Rolfsen, MD, Clinical Fellow in the Division of Allergy, Pulmonary and Critical Care Medicine, for a story about his presentation at the American Thoracic Society meeting on metal health outcomes following ICU discharge. Nashville Scene reporter Hannah Herner interviewed James Crowe, MD, Director of the Vanderbilt Center for Antibody Therapeutics, for a story about his efforts to prepare for the next pandemic by isolating antibodies that can neutralize dangerous viruses. Medscape reporter Kathleen Doheny interviewed Neesha Choma, Associate Chief of Staff of Vanderbilt University Hospital, for a story about how hospitals can reduce readmissions.
GLP-1 and reduced cancer risk discovery earns UT Health San Antonio fellow prestigious Helio NextGen Disruptor Award
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First-of-its-kind discovery earns UT Health San Antonio Mays Cancer Center fellow prestigious Helio NextGen Disruptor Award
Colton Frisco Jones, MD, a 2nd-year fellow at the Mays Cancer Center at UT Health San Antonio, the academic health center of The University of Texas at San Antonio (UT San Antonio), recently earned the prestigious Healio NextGen Disruptor Award at the American Society of Clinical Oncology (ASCO) 2026 annual meeting in Chicago.
Bo McCalebb Inducted into the Allstate Sugar Bowl New Orleans Sports Hall of Fame
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Myles Garrett's Rise Could Fuel T.J. Watt's Next Steelers Surge
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Gov. Scott vetoed the Legislature’s latest attempt to lower health insurance costs. What’s next?
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A new vision for quantum computing takes a big step forward, with new grant
A $4 million National Science Foundation grant will propel the next phase of a Yale-led project to build a quantum computer with an innovative new design.
Democratic socialists cemented power in New York. Next, the rest of the country?
The Democratic Socialists of America won with support outside their usual base. Winning outside New York may be a different challenge.
Ohio State–led team secures NSF award to advance to next phase of the National Quantum Virtual Laboratory program
The Ohio State University is strengthening its growing prominence in quantum science, technology, and education with a $4 million, two‑year Phase II design award from the U.S. National Science Foundation (NSF) to advance a national effort focused on next‑generation quantum sensing.The funding is helping to bring together top researchers and ...
'This is the next jump in technology': World's first sub-1nm chip keeps Moore's Law alive a little longer
IBM's NanoStack architecture has helped scientists cram 100 billion transistors onto a computer chip, delivering 50% better performance and consuming 70% less energy than the current generation.
Who will be the next chancellor?
Whether Andy Burnham picks Miliband, Streeting or someone else, they will face a ‘bulging in-tray’