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NC State Health Plan reaches deal with Atrium Health, but using WakeMed will still cost more
The NC State Health Plan, which covers state employees, teachers, retirees and beneficiaries, reaches a cost agreement with Atrium Health.
NASA Leaders Visit Morehead State to Highlight Space Science Excellence
Morehead State University's growing impact in space science and aerospace education drew national attention as university leaders welcomed top NASA officials and federal policymakers to campus. NASA Administrator Jared Isaacman, NASA astronaut Stephen Bowen and U.S. Rep. Harold "Hal" Rogers visited Morehead State on Monday, Oct. 26, to highlight the University's Space Science Center, its partnership with NASA and its contributions to preparing the next generation of scientists, engineers and space professionals. For more than two decades, Morehead State has built a nationally recognized space science program that combines classroom learning with hands-on participation in real-world aerospace projects. MSU has developed significant capabilities in satellite tracking, mission operations and space systems engineering through its work with NASA and commercial aerospace partners. Learn about Space Systems Engineering at MSU by contacting Space Science Center Executive Director Dr. Ben Malphrus at b.malphrus@moreheadstate.edu or calling 606-783-2212.
7 Health Benefits of Basil, From Antioxidants to Stress Relief
The health benefits of basil go far beyond flavor. From antioxidants to potential stress relief, here's why this fragrant herb deserves a place in your diet.
Social Security chief identifies 'first solution' as program faces funding concerns
Social Security Administration Commissioner Frank Bisignano says eliminating fraud, waste and abuse is the 'first solution' to protecting Social Security benefits.
Week 8 fantasy kicker rankings: Top streamers, starts
There should be plenty of points scored when the Minnesota Vikings face the Detroit Lions' league-worst defense. Kicker Will Reichard should benefit.
'Confidence in the opportunities': How OU's using 2025 run as 'a template'
Following a season high in offensive yards in a 23-15 win over Mississippi State (4-3, 2-3 SEC), head coach Brent Venables and offensive coordinator Ben Arbuckle spoke to the media
A week after health episode, Ben Kindel returns to practice with Penguins
The 19-year-old center took part in a long practice Tuesday and reported no concerns afterward. His return is still to be determined.
Michelin’s first Wilmington picks boost business already, restaurateurs say
WILMINGTON — The world’s top culinary benchmark has officially arrived in the Cape Fear, with the famed Michelin Guide bringing two local eateries to the forefront of its American South…
Small business owners challenge incumbent to represent Ohio District 4
Voters are slated to decide this November who will represent Ohio’s 4th Congressional District for the next two years.
State Health Plan votes on plan to avoid running out of cash by early 2027
The plan’s Board of Trustees is addressing the projected low cash balance using the Retiree Health Benefit Fund.
NC Republican Congressmen buy TV ads in deep-red districts as election looms
Incumbent Republicans in Congress from seven conservative districts in North Carolina are running TV ads to help their re-election campaigns. It's a sign that the GOP could be worried about districts designed to be safe for Republicans amid what could be a wave year for Democrats.
Bengals Face a Potential Trap Game This Week Against Titans
Cincinnati is coming off a statement win over the Ravens, but can the Bengals avoid a trap game against a struggling Titans team that has shown signs of improvement over the past two weeks?
Scientists are using sharks to forecast hurricanes. The secret lies in what they track beneath the waves.
Researchers at the University of Delaware are using specialized telemetry tags on sharks to measure ocean heat and improve hurricane intensity forecasts along the East Coast.
I'm a bus driver at Walt Disney World at 51 years old; great benefits
Driven by a love for Disney World, I decided to move to Florida at 44 to drive a bus. The health benefits and pension make it all worth it.
Nithya Raman Is Not L.A.’s Mamdani. But She Might Become Mayor, Too.
Little known a year ago, Nithya Raman is a Democratic Socialist drawing comparisons with New York’s Zohran Mamdani. She has mounted a strong challenge to the incumbent, Karen Bass.
Opinion: Chicago’s push to protect gig workers threatens their independence
Chicago's delivery rules risk gig worker flexibility. States should offer portable benefits, argues an Americans for a Modern Economy adviser.
Encompass Health Corporation (EHC) Helped Drive Madison Small Cap Fund’s Healthcare Outperformance in Q3 2026
Madison Investments, an investment advisor, released its “Madison Small Cap Fund” Q3 2026 investor letter. A copy of the letter can be downloaded here. The Fund outperformed its small-cap benchmarks during the third quarter of 2026, despite a challenging environment for quality-focused investors as speculative AI-related stocks retreated, inflation remained persistent, and rising bond yields […]
Acentra Health Names Mihriban Brickner as Senior Vice President of Operations
Experienced healthcare operations leader will drive company's key Integrated Health Solutions initiatives and support clients Mihriban Brickner Acentra Health SVP Operations Acentra Health Names Mihriban Brickner as Senior Vice President of Operations. Experienced healthcare operations leader will drive company's key Integrated Health Solutions initiatives and support clients. MCLEAN, Va., Oct. 27, 2026 (GLOBE NEWSWIRE) -- Acentra Health, a technology and health solutions company dedicated to ac
New Paterson pantry serves freshness, health, and hope
The “supermarket experience” is back at the People’s Choice Father English Food Pantry in Paterson, N.J. Thanks to a recent two-year, more than $600,000 renovation, this essential social-services facility is brighter and more welcoming, with a larger — and fresher — food selection to benefit local families and individuals in need. On Oct. 19, Bishop Kevin J. Sweeney blessed the refurbished 4,000-square-foot food pantry. The improvements have allowed the facility to return to its approach of restoring the dignity of clients experiencing food insecurity by enabling them to shop as they would in a commercial supermarket. Guests receive “shopping points”
Ancient fish, modern science: Rice researchers go fishing in Houston’s backyard
A few dozen miles from the Gulf of Mexico, in a river winding through the Houston area, a fish with a lineage stretching back tens of millions of years was waiting beneath the surface. When it took the bait, Rice University researchers got the chance to bring the specimen back to the lab.
Denver Broncos snaps and analysis in win over Arizona Cardinals
The inactive players for the Denver Broncos game against the Arizona Cardinale had two starters (still), but the other five are regulars on the inactive list: QB Sam Ehlinger, DL Jordan Jackson, CB Pat Surtain II, S Talanoa Hufanga, TE Dallen Bentley, OL Kage Casey, DL Tyler Onyedim. Offense This was another game where the […]
Police politics infuse LA mayor’s race
Los Angeles Police Chief Jim McDonnell stands in the middle of a debate between incumbent Mayor Karen Bass and her challenger City Councilmember Nithya…
Ravens’ Jesse Minter Pressed Over Contradicting Lamar Jackson Injury Updates
It has been a while since the last time Baltimore Ravens quarterback Lamar Jackson saw action on the field. He has already missed three games, with Baltimore losing two of those, including Sunday’s 35-13 defeat at the hands of the Cincinnati Bengals at home. On Monday, Ravens head coach Jesse Minter was asked to clarify […] The post Ravens’ Jesse Minter Pressed Over Contradicting Lamar Jackson Injury Updates appeared first on Gridiron Heroics.
Manchester Museum unveils partnership with Indian science centre
Collaboration with the Science Gallery Bengaluru will focus on young people and environmental action
What Lies Beneath the Noise
Can the Democratic party really pull off a massive midterm swing?
NationsBenefits Expands Member Access to Health Benefits Across Costco Stores Nationwide
PLANTATION, Fla., October 27, 2026--NationsBenefits, the leading healthcare fintech and benefit outcomes company, today announced a nationwide retail integration with Costco Wholesale to roll out its proprietary Basket Adjudication Service (BAS). Through this integration, health plan members with a NationsBenefits Flex Card can now redeem their benefits at more than 600 participating Costco Wholesale warehouses across the United States.
The broccoli-cooking mistake that may reduce its health benefits
Popular preparation methods might be removing key nutrients from this vegetable. Here’s how experts suggest cooking it instead.
Newcastle appoint Tomas Amaral as new head of first-team recruitment
The 35-year-old was most recently sporting director at Spartak Moscow after scouting roles at Benfica, Real Valladolid, Eibar and Granada.
The gut health category is crowded: How can brands truly stand out?
For formulators, the challenge is no longer simply finding a gut health ingredient, but a product that provides the credible science, relevant benefits and the flexibility to support innovative product formats
Phantom Blade Zero PC Performance Benchmarks – Fast-Paced Wuxia That Looks Phenomenal In Path Tracing & Boosted By NVIDIA RTX Tech
Phantom Blade Zero is out now on PC, offering increased graphics fidelity through NVIDIA's DLSS 4.5 technology, Path Tracing, and much more.
Intermountain Health Groundbreaking on a New Era of Children’s Health for Nevada
Nevada’s first stand-alone children’s hospital groundbreaking marks the community-wide effort to build a stronger pediatric health system. Intermountain Health Felicia and Ben Horowitz Children’s Hospital Model presented at groundbreaking for the Intermountain Health Felicia and Ben Horowitz Children’s Hospital LAS VEGAS, Oct. 27, 2026 (GLOBE NEWSWIRE) -- For Media Use, use the following link for photos/videos: https://securedrop.intermountain.net/securedrop/public.php?service=files&t=010f47fe8a
Intermountain Health Breaks Ground on Felicia and Ben Horowitz Children's Hospital
Intermountain Health broke ground on the new Felicia and Ben Horowitz Children's Hospital Monday, celebrating progress in the work to create Nevada's first stan
The Christmas at the Kringles Parody Popcorn Bucket Is Festively Unhinged
Christmas at the Kringles, the upcoming genre-bending horror comedy from Briarcliff Entertainment, has unveiled the first look at its parody popcorn bucket. Given what we know about the movie, the sou...
The Christmas at the Kringles Parody Popcorn Bucket Is Festively Unhinged
Christmas at the Kringles, the upcoming genre-bending horror comedy from Briarcliff Entertainment, has unveiled the first look at its parody popcorn bucket. Given what we know about the movie, the souvenir offers the perfect tease for its weird and unusual narrative. Why the Christmas at the Kringles popcorn bucket fits the film’s strange holiday premise […] The post The Christmas at the Kringles Parody Popcorn Bucket Is Festively Unhinged appeared first on ComingSoon.net - Movie Trailers, TV &
Cam Grandy headed back to Cincinnati
The Cincinnati Bengals are signing tight end Cam Grandy off the practice squad of the Minnesota Vikings
Principal’s small business benefits arm posts 10% sales growth in a softening market
Specialty benefits loss ratio holds below target range as Beam Benefits adds its first customers
Prominent political figures are campaigning nationwide, what about in Wisconsin?
WLUK FOX 11 is your source for Balanced News and Severe Weather Coverage for Appleton, Shawano, Sturgeon Bay, Kewaunee, Two Rivers, New London, Bonduel, Pulaski, Suamico, Menasha, Neenah, Shiocton, Ashwaubenon, Algoma, Mishicot and Wrightstown.
Benjamin Netanyahu battles for political survival
Israelis will vote in the country’s first nationwide election since the attacks of Oct. 7, 2023.
Florida voters — almost 2.8M — surge past '22 midterm benchmark as early voting goes statewide
The first weekend of early voting being available in every Florida county pushed the number of votes cast for the Nov. 3 election towards 2.8 million, more than 20 percent of the turnout in the prior midterm election in 2022.
Want to Lower the Cost of Living? Unrig our Democracy.
Going into the midterms, voters are feeling the squeeze in their wallets and need relief. The answer lies in holding accountable politicians who prioritize their wealthy benefactors over them.
The benefits — and perils — of expanding the map: From the Politics Desk
Plus, how the nascent 2028 primary is playing out on the 2026 campaign trail.
Chambers’ donations outpace Millers 3:1 in battleground 41st District race
Brad Chambers, the Democratic challenger in the race for the 41st Pennsylvania House District, has raised three times more campaign funds than incumbent Brett Miller since June. Compared to Miller,
Fort Bend County judge candidate Daniel Wong uses AI to create Black 'supporters' in political ad
Fort Bend County Judge Daniel Wong is facing heat for posting a campaign video generated by artificial intelligence that depicts Black people voicing support for his campaign.
Kirk Cousins to remain starting quarterback
Raiders QB Kirk Cousins will not be benched even though the team is on losing streak
Fort Bend judge candidate uses AI to create Black 'supporters' in ad
Fort Bend County Judge Daniel Wong is facing heat for posting a campaign video generated by artificial intelligence that depicts Black people voicing support for his campaign.
How James Uthmeier’s attorney general campaign benefitted from Alligator Alcatraz
Some contributions from contractors occurred just days before or after the companies landed major state contracts.
Jon Husted to hold small business roundtable in Guernsey Co. today
Sen. Jon Husted is scheduled to hold a small business roundtable at The Bear's Den Steakhouse today, according to a release. He will be accompanied by U.S. Small Business Administrator Kelly Loeffler and will speak to employees and local leaders about the Working Families Tax Cut Act and the benefits for small businesses and owners in southeastern Ohio. The time of the roundtable was not included in the release.
How Eaton’s (ETN) Data Center Business Complements Amphenol’s AI Infrastructure Opportunity
Burke Wealth Management, an investment management company, released its “Focused Growth Strategy” Q3 2026 investor letter. A copy of the letter can be downloaded here. The fund delivered strong results in the third quarter of 2026, benefiting from a sharp recovery in enterprise software and solid corporate earnings amid continued market volatility. The composite returned […]
Ben Johnson sounds off on Bears' run defense vs. Patriots
Chicago Bears head coach Ben Johnson reacts to the Bears' run defense in their 30-24 win against the New England Patriots.
Is Anton Bonke Already Falling Out of Michigan State's Rotation?
After a sudden benching and dwindling minutes in exhibition play, the 7-foot-2 transfer faces an uncertain future as Tom Izzo reshuffles the Spartans’ frontcourt before tip-off.
Intel Core Ultra 4000 Nova Lake-S leak: 28-core CPU beats Core Ultra 9 285K in single-thread test
Early Nova Lake-S benchmark results suggest improved single-thread performance over Arrow Lake. However, the 28-core sample still trails Core Ultra 9 285K in the overall CPU Mark test.
📈 Monday data: The bottleneck isn’t intelligence
In the AI Investment Brief today: CapEx updates and lease commitment breakdowns Anthropic co-founder Jack Clark recently said in a speech at the IMF that the singularity has begun: For many years, researchers and science fiction authors have forecast a future in which AI systems drastically increase the pace of overall scientific and technical progress, making things move so quickly that it is hard for humans to keep up. They call this the singularity. I believe that this year we have gained convincing evidence that it has now begun. This follows Anthropic’s claim that in August, 26% of its AI R&D was led by Claude, with a human supervising its work. In October, OpenAI posted 719 math manuscripts1 made by its internal model. Math and coding are two fields where a research loop can close without leaving the desk. But can the loop close in the rest of science? Subscribe The loop is real The idea is not new. Mathematician Irving John Good, who had worked with Alan Turing at Bletchley Park, argued that a machine smarter than us “could design even better machines; there would then unquestionably be an ‘intelligence explosion,’ and the intelligence of man would be left far behind.” The Gödel machine, a self-improving computer that can rewrite its own code better than its prior, was first proposed in 2003. In 2025, researchers at Sakana AI and the University of British Columbia set out to show that this was possible. Their agents iteratively improved their own code through a feedback loop, resulting in gains of 30 pp on SWE-bench and more than 15 pp on Polyglot, testing coding skills beyond Python. The idea has since been tested in other labs. A Gemini-powered agent called AlphaEvolve found a faster matrix multiplication kernel used for training Gemini, speeding up the kernel by 23% and cutting Gemini’s training time by 1%. In China, MiniMax reported that its M2.7 model worked on improving its own agent’s harness, skills, sampling and memory. Over 100 rounds of rewriting led to a 30% gain, per its internal evaluations. In each case, what was being rewritten was not the model itself but everything around it. Is it better than human work? In September this year, in what seemed like a milestone, an AI-built agent proved as good at improving other AI agents as a human-built one. It did that in what appeared to be half the steps. But the result was inconclusive: the differences between runs were greater than the difference between the AI- and human-built agent results. Nonetheless, this is increasing the chatter around recursive self-improvement (RSI) in AI. Google’s Sundar Pichai said that “you have RSI loops along with AI researchers in various aspects of model development.” Sakana AI published a paper on RSI through multi-agent collaboration, finding that after two cycles its system scored 1.2–1.6x better per output token than the base model across four research benchmarks. Ramez Naam challenges that view. He splits AI self-improvement into five overlapping types. The first four describe how autonomous the AI is; so far, only types 1 and 2 have been observed. The fifth type describes accelerating returns, and he notes that greater autonomy doesn’t guarantee a takeoff scenario. Instead, each round of self-improvement would need to deliver at least as much as the last. The results from Sakana, AlphaEvolve and MiniMax above might look like type 3 or type 4 autonomy. But in each case, the AI wasn’t updating its own weights directly, only the ancillary parts — the harness, the memory. And where Claude leads its own R&D, for now a human still supervises.
Joe Burrow Silences Fans Who Called Him ‘Washed’ and ‘Overrated’ as Bengals Shut Down Ravens
Fans have learned not to count out Joe Burrow too quickly. The Cincinnati Bengals quarterback, 29, and his team had what The Athletic described as one of their worst offensive halves in recent history against the Baltimore Ravens on Sunday, October 25. Burrow went 6 of 12 passing for 43 yards in the first two […]
Lula celebrates election win as Brazil markets tumble
World leaders, except for US President Donald Trump, congratulated Brazilian incumbent Luiz Inacio Lula da Silva on his election win Monday, while markets plummeted following the shock result.The US p...
'Yes Bibi or No Bibi': Netanyahu's political future overshadows Israel's election
Israel's upcoming legislative election could reshape the country's political future amid deep divisions over Benjamin Netanyahu's leadership. Former government spokesperson Eylon Levy tells Euronews w...
'Yes Bibi or No Bibi': Netanyahu's political future overshadows voting
Israel's upcoming legislative election could reshape the country's political future amid deep divisions over Benjamin Netanyahu's leadership. Former government spokesperson Eylon Levy tells Euronews what is at stake and why another war with Iran may be imminent.
Israel heads to the polls as Netanyahu faces political reckoning
Israelis are preparing to vote on Tuesday in their first general election since the terrorist attacks on October 7, 2023, and the subequent war in Gaza, with Prime Minister Benjamin Netanyahu...
Knox County Deputies Announce Backing for Sheriff Polky
ROCKLAND — The Knox County Deputy Sheriff’s Association Lodge #700 announced Oct. 26 that it is endorsing incumbent Patrick Polky for Sheriff."Our lodge represents the law enforcement personnel of the
Arsenal 29yo very keen to return to England squad
Ben White is keen to return to the England squad next month, and he’s enjoying finally being able to share his minutes with Jurrien Timber.Photo by Maurizio Lagana/Getty ImagesFor a long time at Ars...
At Exit Space, classes for adults welcome dancers of all levels
Adults are stepping up to the barre and to enjoy the physical benefits and camaraderie of ballet dance classes at Seattle's Exit Space.
Phantom Blade Zero Benchmarks & PC Performance Analysis
Phantom Blade Zero uses Unreal Engine 5.7.4, and it has Denuvo. So, time to benchmark it and see how it runs on PC.
Rueben Chinyelu named CBS Sports preseason Defensive Player of Year
CBS Sports named Florida center Rueben Chinyelu its preseason Defensive Player of the Year after his dominant 2025-26 season.
Maximizing the QBI Deduction: Planning Considerations for Construction Business Owners
Learn how appropriate tax planning can enable the QBI deduction to benefit construction businesses.
Intuition pushed mom to keep checking for breast cancer
Michigan mom had no reason to suspect cancer. But instinct nudged her to find out for sure — and carried her through challenging treatments to remission.
Who’s spending money on the California insurance commissioner race
Jane Kim and Ben Allen have promised not to take insurance money, but an outside PAC supporting Allen has received industry donations.
Partner1 Renews WBENC Women's Business Enterprise and Women-Owned Small Business Certifications
Recertification caps a year in which founder and CEO Juhi Saha was named to Inc.’s 2026 Female Founders 500 and Partner1 was named an Inc. Power Partner for the second year runningPLEASANTVILLE, N.Y., Oct. 26, 2026 (GLOBE NEWSWIRE) -- Partner1, the advisory firm and software platform behind the partnership strategies of fast-growing B2B software companies, today announced it has renewed its Women’s Business Enterprise (WBE) and Women-Owned Small Business (WOSB) certifications from the Women’s Bu
Iranians pin hopes for political change on Netanyahu's election win
Iranians are looking to Israel's election as a potential turning point in their country's political future, with supporters of Benjamin Netanyahu hoping his victory will bring renewed pressure on the Islamic Republic.
Inside Business 2026 Top Forty Under 40: Tamika Benson, The Still She Rose Foundation VA
Tamika Benson is the founder and president of The Still She Rose Foundation VA.
Inside Business 2026 Top Forty Under 40: Lexie Barker-Taplett, Charles Barker Automotive
Lexie Barker-Taplett is the dealer principal at Charles Barker Automotive/Mercedes-Benz of Virginia Beach.
Michigan’s new $82M unemployment system launches Nov. 9 after long development process
The new MiUI system will allow unemployed workers to file claims, certify for benefits, view payments and do other tasks through the platform.
How Functional Foods Deliver Bioactive Compounds and Support Gut Health
Functional foods use delivery systems such as encapsulation, lipid carriers, and hydrogels to protect bioactive ingredients and control their release during digestion. These technologies may improve nutrient availability, but human studies are needed to establish their health benefits and long-term safety.
Netanyahu might be finished but his policies toward the Palestinians will largely endure
JALUD, West Bank (AP) — Israel's elections Tuesday could mark the end of Prime Minister Benjamin Netanyahu 's decades-long political career.But his legacy in the Israeli-occupied West Bank — of massiv...
Anthony Scaramucci Says Vivek Ramaswamy 'Disgraced Himself' in Ohio Governor Race: 'He’s Finished Himself as a Future Candidate'
SkyBridge Capital founder Anthony Scaramucci accused Ohio gubernatorial hopeful Vivek Ramaswamy on Sunday of abandoning his core political principles to win the high-stakes race.Scaramucci’s Scathing ...
Lula is declared winner of Brazil's election as Bolsonaro rejects results
Flavio Bolsonaro is refusing to concede defeat to incumbent President Luiz Inácio Lula da Silva, who bested him by nearly 4.4 million votes, following a chaotic delay in poll closing
Bengals Shut out in Disastrous First Half vs Ravens
The Cincinnati Bengals are off to a first half they’d like to forget. Cincy trails the Baltimore Ravens 13-0 in Baltimore.The story has been the Cincinnati Bengals’ defense which has been struggling against this Ravens offense.The Ravens got off to a hot start as Zay Flowers took a 48-yard pass to the house from backup […] The post Bengals Shut out in Disastrous First Half vs Ravens appeared first on HEAVY.
Here's how Bengals' second half vs Ravens made NFL history
The Cincinnati Bengals became just the 10th team in NFL history to get shut out in the first half and then score 35 points or more in the second half.
Here's how Bengals' second half vs Ravens made NFL history
The Cincinnati Bengals became just the 10th team in NFL history to get shut out in the first half and then score 35 points or more in the second half.
Presidential race in Bulgaria heads to runoff due to record low turnout
In a surprisingly strong performance, the candidate of the pro-Western reformist opposition, Andrey Gyurov, will face the incumbent leftist president, Iliana Yotova, setting clear lines of division regarding the country’s future relationships with other nations.
Ravens surrender 35 unanswered points in stunning loss to Bengals
Baltimore squandered a 13-0 halftime lead as Joe Burrow threw four touchdown passes and Cincinnati handed the Ravens a 35-13 defeat
Yankees Social Media Spotlight: The MA kids head to MSG
Cam Schlittler and Ben Rice head to Madison Square Garden to watch the Knicks raise a banner.
Instant analysis after Bengals wake up, trounce Ravens
Quick notes and takeaways after the Bengals beat the Ravens in Week 7.
Erick All leaves Week 7 game early
Bengals TE Erick All ruled out after suffering a knee injury in Week 7
Barcelona host Real Madrid in anticipated Clásico clash
2026-10-25T20:12:58ZThere have been a few crunching tackles on both sides in the last few minutes and now the benches have taken exception as there is a little coming together in the center of the par...
Ravens lose standout rookie to injury against Bengals
The Baltimore Ravens have lost a key rookie to injury, forcing another change up front against the Cincinnati Bengals.
Trump’s Election Attacks Enter New Pre-emptive Phase
A lawsuit by the Justice Department challenging a potential narrow loss by the GOP Senate incumbent in Alaska reflects a new tactic by the president to try to shape the election results.
Blanche says Trump isn't trying to meddle with Alaska election results by suing over Senate race
Attorney General Todd Blanche is defending the Trump administration’s lawsuit to block certification of Alaska's Senate results if incumbent Republican Dan Sullivan loses the race.
Blanche says Trump isn't trying to meddle with Alaska election results by suing over Senate race
Attorney General Todd Blanche is defending the Trump administration’s lawsuit to block certification of Alaska's Senate results if incumbent Republican Dan Sullivan loses the race.
In West Maui, Democrat-turned-Republican defends House seat against Lahaina Strong organizer, local business advocate
Incumbent Rep. Elle Cochran, Green Party candidate Pā’ele Kiakona and Democratic nominee Sne Patel are battling to represent West Maui at a pivotal time in the fire recovery.
Republican responds to AI video in Fort Bend County political battle
Fort Bend County has seen plenty of controversy at its highest levels.
RJW Logistics to open second Northwest Arkansas office
Chicago-based RJW Logistics Group, which has a Bentonville office, plans to open an additional Northwest Arkansas office amid client growth and to support demand for a new logistics program offered...
Chivu: “The boys gave everything right to the end”
Cristian Chivu wasn't the only one who couldn't bear to watch Zielinski's decisive penalty. The Inter coach bent over on the touchline, looking away as the midfielder stepped up to take it. When the b...
Baltimore Ravens vs. Cleveland Bengals Week 6 game discussion
Join the discussion about the Ravens’ Week 7 matchup with the Bengals!
ESMO: Roche touts ‘convincing’ phase 3 KRAS data after win over rivals
Roche has shed more light on its investigational KRAS G12C inhibitor's phase 3 victory over Amgen’s Lumakras and Bristol Myers Squibb’s Krazati. The open-label Krascendo 1 trial enrolled 338 people with previously treated KRAS G12C-mutated non-small cell lung cancer (NSCLC). Patients who had already received a KRAS G12C inhibitor or pan-KRAS/RAS inhibitor were excluded from the trial. Participants received either divarasib once daily, Lumakras once daily or Krazati twice daily. Roche announced back in July that divarasib had demonstrated statistically significant improvements in progression-free survival (PFS) and overall survival (OS), meeting the trial’s primary and key secondary endpoints. But the Swiss pharma had been holding back the detailed data until now. At the European Society for Medical Oncology (ESMO) Congress in Madrid, Roche revealed that median OS for the 167 patients who received divarasib was 17.7 months, compared to 12 months for the 171 patients who received Lumakras or Krazati. The benefit was similarly clear when it came to median PFS, which stood at 9.8 months versus 5.7 months, respectively. A total of 44% of patients receiving divarasib were alive without disease progression at one year, compared to 24% of the control group, according to Roche’s presentation. It was a similar story for the objective response rate, which came in at 58% for divarasib versus 32% for the control group, while median duration of response was 11.9 months versus 6.9 months. Stefan Frings, M.D., Ph.D., deputy chief medical officer at Roche Pharma, told Fierce that the data made for a “very comprehensive, strong package, which should be convincing to health authorities.” “It’s an important advance for patients with lung cancer,” Frings said in an interview at a Madrid hotel during the conference. “It's a second-line setting, and patients who receive divarasib benefit compared to the current first-generation KRAS G12C inhibitors by having far longer overall survival,” he continued. “They live longer. They have better progression-free survival, better response rates, and with a safety profile which is—if [anything]—even better,” he said. According to Roche, 4.8% of patients receiving divarasib discontinued treatment due to treatment-related adverse events, compared to 11.7% in the control group. Serious treatment-related adverse events were also less common with divarasib, at 7.8% versus 15.2%. Roche’s confidence in divarasib had been building even before this phase 3 success. The candidate had already shown better potency and selectivity than the incumbent KRAS G12C inhibitors Krazati and Lumakras in preclinical tests. After cross-trial comparisons suggested that the edge translated into better clinical outcomes, Roche axed a study comparing divarasib to the chemotherapy docetaxel and went toe-to-toe with Lumakras and Krazati. “We designed the drug on purpose with higher potency and better selectivity,” Frings explained. “So, based on preclinical models, we clearly knew it would be superior to the first generation.” “It’s honestly not so frequent that pharma companies go head-to-head,” he added. “But if you want to make a point, if you want to convince payers, prescribers and patients … then a head-to-head win is rather rewarding.” While Amgen and BMS reached the regulatory finish line first for KRAS G12C-mutated, locally advanced or metastatic NSCLC in 2021 and 2022, respectively, they have struggled to capitalize on their head start. Krazati brought in $55 million for BMS in the second quarter, while Lumakras delivered $111 million to Amgen. For its part, Roche is aiming for peak divarasib sales of 1 billion to 2 billion Swiss francs ($1.2 billion to $2.5 billion), according to Frings. The Big Pharma is currently recruiting patients into a phase 3 trial comparing divarasib plus Keytruda against Keytruda plus chemotherapy in previously untreated advanced or metastatic nonsquamous KRAS G12C-mutated NSCLC. Roche has previously suggested that sales in metastatic disease would account for most of the forecast. Frings was tight-lipped on the exact timeline for a regulatory filing but said the Swiss pharma is “certainly keen to get this to as many patients as possible around the world.” Roche has more RAS drugs coming up behind divarasib. The pharma has already launched phase 1 trials of a pan-RAS inhibitor called RG6505 and a KRAS G12D inhibitor dubbed RG6620 in solid tumors. Roche’s partner Chugai Pharmaceutical is also testing a pan-KRAS inhibitor called AUBE00. Roche has made a “deliberate effort” to test a range of RAS drugs, Frings said. “If you have many rare mutations and you are scrambling to find sufficient patients, a pan-RAS inhibitor makes a lot of sense,” he explained.