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Could a change in diet improve mental health? Metabolic psychiatry, explained.
Patients rave about how the keto diet has helped ease mental health symptoms. The data are limited, but encouraging.
Laboratory exposure and poor diet linked to health symptoms in young scientists
A research team has found that frequent exposure to laboratory chemicals and low consumption of antioxidant-rich foods are jointly associated with a greater likelihood of self-reported health symptoms among young scientists. Survey participants who frequently handled chemicals and consumed few antioxidant-rich foods had nearly three times the odds of reporting fatigue, headaches, pallor, or easy bruising compared with their less-exposed, better-nourished peers. The study also showed that stronge
Southwest Boulevard streetscape project brings new barriers, restaurants see business rebound
A new set of concrete barriers installed as part of a road diet near Southwest Boulevard and West 25th Street is creating confusion for some drivers.
Is It Healthy to Eat Cheese Every Day? Dietitians Reveal the Answer
Cheese is delicious, but how much is too much? Dietitians share the healthiest way to get your cheese fix on a daily basis.
A bitter pill: are you wasting your money on supplements?
Will collagen make you look younger? Could magnesium help you sleep better? Or are the benefits overstated? A dietitian reveals which are worth taking
Does public health *need* MAHA?
Last week, our friend Dr. Craig Spencer sparked an ongoing volatile discussion with his Atlantic article “Public Health Needs MAHA.” Some have come out in strong dissent, others are cheering, and others are simply lamenting that we find ourselves in such a divided world to begin with. We will dare to dip our toes in these controversial waters, too. Does public health need MAHA? We think in some ways yes, and in other ways, no. MAHA leaders versus the everyday MAHA supporter The vitriol in this debate mostly comes from one collapsed distinction: the leadership of MAHA is not necessarily the same as the people who support it. Say “MAHA” and most people picture RFK Jr. Fair enough, as he coined the term and holds most of the power. And, yes, some MAHA followers treat Kennedy as something close to a saint. But talk to the grassroots, and it’s not a monolith. They’re Republicans, Democrats, and Independents. People who distrust vaccines and vaccine supporters. It’s a wide, eclectic coalition. The data backs this too: 4 in 10 Americans support the movement—that’s a lot of people! But according to polls, vaccines and medical choice (the issues most tied to Kennedy personally) are cited by only 4% as their reason for supporting the movement. For many, the motivations are much broader. Many MAHA supporters are signing up for the idea that “something needs to change” with health in this country. They’re asking good-faith questions about corporate influence on our health systems, health care costs, nutrition, chemicals, and clean air and water. These are all questions that plenty of public health professionals recognize as legitimate and also care about very deeply. Blurring the lines between the leadership and grassroots does real damage in two important ways: It hands the 4 in 10 exactly the narrative already fed—that the health ecosystem doesn’t listen, doesn’t care, and paints every critic with the same brush. It gives the actual bad actor more power. RFK Jr. has done irreparable damage and can’t be trusted. What the MAHA movement gets right A healthy population is something the public health field was literally built on, and many of these topics are things we have dedicated our lives to. Yet the MAHA movement has captivated nearly half the country in a way the public health establishment has failed to achieve. So that means MAHA is doing something right. Some of it may be timing (after a Covid-19 pandemic and deep frustration and mistrust with institutions). The movement also does three other things really well: 1. It gives a new, louder voice to system failures. While MAHA is not a monolith, one theme stays consistent across their stories: the system failed them. For some, it was the system that flooded their communities with opioids and then walked away. For others, it was the system that let their business collapse during Covid with no safety net in sight. For others still, it was the system that failed to help them manage a complex chronic illness, bouncing them from physician to physician without any real answers. And in many ways, our health ecosystems are failing Americans. Why are medical bills so incomprehensible? Why do some kids get a healthy school lunch and others don’t? Why do an epidemiologist and a MD/PhD student have to start newsletters in the middle of the biggest public health emergency in a century, just so people can get straight information? Because the systems failed. This deep-seated frustration driving many Americans to search for solutions elsewhere needs to be recognized. 2. MAHA has brilliant comms central to their efforts. MAHA figured out something most health institutions still have not: the information landscape changed. It’s participatory now, not top-down; influence runs through many nodes in a community, not one institution; and storytelling and telling audiences “what you really think” moves people more than data dumps do. MAHA goes where audiences are listening, using podcasts, social media, and memes in ways most health institutions would scoff at—but it works. 3. They are very good at organizing. A MAHA meeting feels like a rally: energy, speakers, music, and most importantly, an action for everyone. Someone’s writing the next policy brief, someone’s seeding a narrative, someone knows the next legislative deadline, someone’s sending the text messages for a campaign. None of this is new (ask the civil rights movement), but MAHA knows it works and has capitalized on it. What MAHA gets wrong This list could be much longer, and this newsletter has spent a lot of time covering it, but here are a few things: Poor use of scientific evidence. This is the fundamental problem with many MAHA policies: the hype outpaces the science, and experts are often villainized for pointing this out. MAHA leadership has traded real solutions for cheap wins. For example, instead of taking on the powerful food industry and passing real reforms, it has celebrated french fries made of beef tallow and taken out artificial dyes from still very sugary children’s cereal. These changes won’t move the needle on America’s diet. MAHA leadership has tried to dismantle vaccine access in the U.S. While many MAHA supporters emphasize other issues, the effort to change vaccine policy has become MAHA’s signature effort. This is not surprising given RFK Jr.’s extensive track record campaigning against vaccines. It has rallied behind the wrong leader. RFK Jr. has a decades-long track record of villifying doctors, scientists, and public health workers, well before he became HHS secretary. He is known for his decades-long work sowing distrust in vaccines as well as life-saving treatments like antiretroviral therapy for HIV. This is not a serious person who can move the needle on health in the U.S, and he has already done serious damage. Public health needs more than defense Defending the evidence is absolutely necessary so health in the U.S. doesn’t move further backward. The public health establishment is very good at defense. The problem is this defense often sounds like defending the status quo, which has failed many people. Public health needs to offer an alternative to RFK Jr.’s MAHA—one that is rooted in evidence, truly listens to and addresses people’s frustrations, and has innovative solutions and the courage to change the systems. How do we get there? Find common ground. Do you know what most people care most about? The abysmal cost of healthcare. Start there. Fight for the human loudly. Too often, communications and engagement center on science with a capital S, funding mechanisms, or the CDC/FDA/NIH. Not the person. So the public doesn’t see themselves in it. Instead, they see people fighting for the very powerful systems that they feel negatively impact their health and well-being. Let the public feel and hear that you see their frustrations, you get it, and you’re fighting for them within the system. Recognize when pro-science messages are alienating people. Facts absolutely matter, but angrily venting only alienates people further. Our friend Elisabeth Marnik recently wrote a New York Times article about her experience growing up unvaccinated and how listening and empathetic conversation are the only ways to reach people that really work (a position backed by communication science). Her comments section was full of hateful comments from pro-vaccine individuals attacking her for daring to suggest we approach vaccine-hesitant individuals with empathy. It is possible to both stand firm behind scientific evidence and empathize with people who don’t trust it. Lean into politics smartly. Often, public health has shied away from politics: Don’t touch it, lest you get burned. But this fails to recognize that the third rail is what fuels the train: who is elected determines our budgets, our priorities, and our authority. Being political means being very savvy in strategy on both sides of the aisle, knowing your audience, and recognizing that political capital is as scarce as financial resources and needs to be allocated accordingly. Bottom line So does public health need MAHA? That’s not really the right question. Public health has a responsibility not to dismiss 40% of the country who feel heard by this movement and are frustrated that the system has failed them. And it has a responsibility to stick to the evidence and recognize MAHA leadership for what it is: a danger to our nation’s health. Both can, and should, be done. Love, YLE and KP A big thanks to Craig Spencer, who had the courage to put his neck out there to start a much-needed discussion at such a critical moment—one that is determining the identity of an entire field. Kristen Panthagani, MD, PhD is completing an emergency medicine residency and research fellowship focusing on health literacy and communication. In her free time, she writes the newsletters You Can Know Things debunking health myths and rumors and The Public Health Roundup. Views expressed belong to KP, not her employer. Your Local Epidemiologist (YLE) comprises a team of experts, ranging from physicians to immunologists to epidemiologists to nutritionists, working together with one goal: to “translate” ever-evolving public health science so that people are well-equipped to make evidence-based decisions. The YLE suite of newsletters reaches over 475,000 people across more than 132 countries. This newsletter is free to everyone, thanks to the generous support of fellow YLE community members. To support the effort, subscribe or upgrade below: Subscribe
Lung tumor signals may tamp down food intake
Researchers found that a high-fat diet in mice amplifies nerve signals between certain lung cancers and the brain, leading to reduced appetite and weight loss.
The 15 Worst Foods for Your Heart Health, According to Cardiologists and Dietitians
Experts say you should avoid them as much as possible.
Overlooked plant proteins may boost gut health
Plant-based diets are good for you. They promote gut, immune, metabolic and cardiovascular health, in part by cultivating a diverse community of intestinal bacteria. These benefits have long been known ...
3 Plant-Based Proteins That Also Boost Gut Health, Per a Dietitian
These protein-rich plant foods also support healthy digestion.
KGK Science secures investment to expand nutraceutical clinical research
North American nutraceutical CRO KGK Science will use growth investment from Maxim Partners to expand clinical trials, decentralised research and regulatory services for dietary supplement and consumer health companies
How Much Red Meat Should You Eat a Week? Dietitian Reveals Answer
In TODAY.com’s Expert Tip of the Day, a dietitian shares her weekly recommendation for healthy red meat consumption.
'Yo-yo' Weight Loss Linked To Decline In Muscle Mass
By Dennis Thompson HealthDay ReporterMONDAY, July 27, 2026 (HealthDay News) — Middle-aged folks have a higher risk of muscle loss if their weight “yo-yos” due to inconsistent dieting, a new study says. People who repeatedly dropped and regained weight wound up losing nearly four times as much thigh ...
Healthwatch: Top foods for better brain health
If you’re looking for ways to improve your brain health, it’s important to pay attention to your diet. But how do you know which one is best?
How ultra-processed foods may damage your long-term brain health
An increasing number of studies have linked ultra-processed foods with depression, anxiety and even dementia. Columnist Helen Thomson explores how strong the evidence is for the brain effects of a diet full of these foods
Pink Penguin Guano Provides Diet Clues
The color of Adélie penguin droppings reveals what the birds are eating, offering scientists a way to track how sea ice conditions influence their diet.
Can You Eat Moldy Bread? Here’s What a Dietitian Says
It is generally not recommended that you consume moldy bread. Some molds have mycotoxins, harmful compounds that may cause gastrointestinal symptoms.
Italy was once a model of healthy eating - now it has a child obesity problem
The Mediterranean diet was a blueprint for healthy living, yet Italian children are among the most overweight in Europe according to WHO.
Planetary Health Diet lowers cardiovascular risk in older women
A 20-year study of more than 65,000 postmenopausal women found that higher adherence to the Planetary Health Diet was associated with a lower risk of overall cardiovascular disease, coronary heart disease, stroke and heart failure.
Top foods for better brain health
Dr. Sandra Darling, a preventive medicine specialist at Cleveland Clinic, recommends a Mediterranean diet because it emphasizes foods like berries, leafy greens, whole grains, and favors fish and p…
Scientists put the “recycling is a distraction” claim to the test
Recycling, greener diets, and other personal climate choices do not seem to distract people from supporting major environmental reforms. A four-year study of nearly 2,800 Australians found that these habits neither increased nor reduced later political engagement.
9 Fruits Highest In Plant-Based Omega-3 That Dietitians Love
An unexpected fruit is one of the richest plant sources of omega-3 fatty acids. Other options can offer a small boost of the famously heart-healthy fats.
This breakfast favorite can be healthy with a few tweaks. Here's why
Experts agree that you don’t need to eliminate cream cheese from your diet. Instead, look for ways to pair it with other healthy foods.
For Yukon River residents, salmon shortages have health consequences
A dietary staple, salmon had — until recently — been the main source of protein for Indigenous people who live along the Interior Alaska river systems.
Japan’s popular prime minister is burning political capital fast
Markets and the Diet are mounting resistance
In the game: New sports nutrition certificate prepares future dietitians
Texas A&M Department of Nutrition has stepped onto the sports nutrition field and is preparing students for peak career performance.
Healthy diet too expensive for one in three people globally, UN report finds
Global hunger declined for the third year in a row in 2025 but experts call for action to bring down costs of fruit, vegetables and dairy as report shows 2.69bn people can’t afford to eat well
The No. 1 Thing to Check on a Nutrition Label, According to a Dietitian
In TODAY.com’s Expert Tip of the Day, a dietitian shares her nutrition label strategy to weed out food that isn’t as healthy as it looks.
Rebuilding the Innovation Engine: How We Got Here And What Comes Next
Federal investment in basic science built America’s innovation engine, but declining support is threatening U.S. leadership, writes Dietrich Stephan, Ph.D.
Best things to buy at Costco, from executive member and dietitian
I'm a registered dietitian with a Costco executive membership. I always buy frozen blueberries, rolled oats, and ground turkey in bulk for easy meals.
Can Intermittent Fasting Help Reduce Visceral Fat?
Some dietary changes and patterns, like intermittent fasting, may be effective for shrinking visceral fat, which could protect your health.
Science & Medicine: Small daily choices can have a big impact on your dementia risk
A UT San Antonio researcher warns that dementia cases could triple by 2050 and that no health system on earth is ready for it. But Dr. Claudia Suemoto says the outlook isn't hopeless: everyday choices around exercise, diet, and community can meaningfully lower your risk, especially if you start by around age 35.
Saturday Posted & Toasted Notes: SummerKnicks finale, Brunson’s business, Ant’s cheat code
You would believe there was a regular-season game played on Friday, as the SummerKnicks and the SummerMavs combined for a dumb 198 points in both team’s Summer League Consolation game. New York used 15 players, and Pacome Dadiet had himself a day to preserve his value entering next season while big man Liam Robbins put […]
Why the Mediterranean diet is so good for you, and 5 easy ways to try it
Researchers have found the diet, which is full of fiber-rich plants and lean proteins, can improve heart health and longevity.
How weight, diet and lifestyles are affecting women’s hormonal health - Baylor College of Medicine Blog Network
Dr. Mona Romezi explains how weight, diet and lifestyle affects women's hormonal health and how to balance those hormones.
Diagnostic dilemma: Junk-food diet caused a teen's permanent blindness
A teen's nutrient-poor diet led to irreversible vision problems.
Older adults who followed popular diet saw surprising mental health benefit
Eating the Mediterranean diet, which is rich in fruits, vegetables, fish and olive oil, may help keep the mind strong even into old age, according to new research.
Popular diet trend could boost mental health among older adults, study finds
Older adults who followed a Mediterranean diet during COVID-19 lockdowns reported less decline in happiness and life satisfaction than their peers.
Dietitian Reveals No. 1 Plant-Based Protein to Boost Heart Health
Plant proteins also come with other healthy nutrients to support heart health.
Could tomatoes protect brain cells? Scientists uncover an unexpected clue in a familiar kitchen staple
Envision a world where an ordinary part of your daily diet acts as a robust protector against one of humanity's most devastating neurological diseases. The search for effective treatments for conditions ...
How Healthy Are Cucumbers?
They’re not exactly packed with nutrition. Here’s why dietitians love them anyway.
9 Easy Healthy Eating Tips via @ConsumerReports
These healthy eating tips don't take much effort to incorporate into your diet, but they can have a big impact on your health.
An anti-inflammatory diet may protect against dementia in some older adults
Recent research suggests that healthy eating habits matter, even when people are already at increased risk of cognitive decline.
Other diet fads championed by MAHA are questionable. But some science and thousands of years of human history are behind fermented foods
“What is it that makes the fermented foods so healthy? The answer is we're still working on it.”
‘EastDiet’ — a homegrown way to better health
‘EastDiet’ — a homegrown way to better health
How to Turn Your Phone Into a Personal Health Dashboard
Free apps from Google, Samsung and Apple can help you track your diet, exercise and well-being — and provide vital information during emergencies.
How to Turn Your Phone Into a Personal Health Dashboard
Free apps from Google, Samsung and Apple can help you track your diet, exercise and well-being — and provide vital information during emergencies.
Dr Oz links obesity to chronic disease surge, says GLP-1s can 'jumpstart' better health
Dr. Mehmet Oz backs GLP-1 weight loss medication, but stresses that diet and exercise remain essential, calling obesity the top driver of healthcare costs.
Warm here, cold there reception greets go-live of ‘Make Hospital Food Healthier’
HHS reiterates: Consistent with the Code of Federal Regulations and CMS guidance, hospitals “should provide inpatient meals that align with the federal government’s Dietary Guidelines for Americans.”
Matt Damon's strict diet choice for dramatic 'The Odyssey' transformation that revealed hidden health issues
‘The Odyssey’ star Matt Damon reveals strict diet choice that 'changed my life' after hidden health issues
Oscar winner Matt Damon says eliminating this from his diet changed his life after finding a food sensitivity during intense training for "The Odyssey."
The order in which food is eaten may have health benefits, dietitian says
Meal Prep Your Way To Better Health
Edwina Clark, Registered Dietician and Founder of Edwina Clark Nutrition, joins Fox 5 DC.
Eating disorders are more than extreme dieting
Eating disorders affect people of all ages, genders and appearances. Your primary care provider can be the first to notice signs and symptoms.
An anti-inflammatory diet may lower dementia risk, even in people with early signs of Alzheimer’s
Healthy eating may help protect the brain, even after early biological changes linked to Alzheimer’s disease have begun, a study suggests. Dr. Leana Wen explains.
The Best Drink for Joint Health, Backed by Registered Dietitians and Science
See the best drink you can sip on for joint health, according to registered dietitians. This healthy beverage is packed with antioxidants, and also benefits your heart, more.
3 ‘Bad’ Snacks That Actually Support Heart Health
Not all “bad” snacks are actually bad for your heart. Learn which dietitian-approved picks can support a heart-healthy eating pattern.
A Dietitian Shares 10 Foods People Think Are Healthy but Are Loaded With Sugar
Some “healthy” foods are surprisingly high in sugar. Our dietitian reveals foods that seem healthy but are loaded with sugar.
12 Healthy, No-Cook Proteins that Dietitians Love for Hot Days
Dietitians share their favorite nutritious protein options that you can use without cooking.
Global dietary estimates for conducting health, environmental and economic impact assessments
Nature Food - The Global Dietary Database for Impact Assessments provides information on what people eat across countries and demographic groups by integrating data on food availability,...
If you’re at risk of Alzheimer’s, these dietary habits can help, study finds
Research suggests diet remains a relevant factor for brain health even after blood markers of dementia are present.
Parents charged with murder after 7-year-old son died of heart disease at 255 pounds
The young boy was allegedly living on a diet of potato chips, French fries and other unhealthy snacks. One prosecutor described the case as "extraordinary, terrible neglect."
A Diet and Workout Plan to Hit Weight-Loss Goals By the End of 2026
A dietitian and personal trainer share the simple plan they give clients who want to lose weight, build strength and feel more energized by the end of the year.
Easy tips for healthy eating this summer
Planning a summer cookout? A dietitian offers easy tips for healthy eating this summer and shares some tasty alternatives.
Dietitians on Healthy Food Pairings To Absorb More Vitamins and Nutrients
In TODAY.com’s Expert Tip of the Day, dietitians share their favorite strategic food pairings to help your body absorb more nutrients.
Aligning patient and planetary health: planetary health diet adherence and inflammatory bowel disease prognosis across Western and Eastern cohorts
npj Science of Food - Aligning patient and planetary health: planetary health diet adherence and inflammatory bowel disease prognosis across Western and Eastern cohorts
Millions take omega-3 fish oil for brain health but a new study found no benefit
Fish oil supplements successfully delivered omega-3s to the brain, but a two-year study found no meaningful benefits for memory, cognition, or Alzheimer’s-related brain changes. The results challenge the idea that fish oil pills can help prevent Alzheimer’s and shift attention toward overall diet and lifestyle instead.
Millions take omega-3 fish oil for brain health but a new study found no benefit
Fish oil supplements successfully delivered omega-3s to the brain, but a two-year study found no meaningful benefits for memory, cognition, or Alzheimer’s-related brain changes. The results challenge the idea that fish oil pills can help prevent Alzheimer’s and shift attention toward overall diet and lifestyle instead.
6 Ways Your Body Can Change After Starting a High-Protein Diet
Adding more protein to your diet can cause several changes in your body, such as better muscle repair and potential digestive issues.
Scientists finally explain why these wild boars stay more radioactive than Chernobyl's wolves - Futura-Sciences
What explains this surprising finding? The answer appears to be a complex mix of history, ecology, and diet. Bavaria’s wild boars mainly feed on underground fungi that absorbed radioactive fallout from both the notorious Chernobyl disaster and Cold War-era nuclear testing. Unlike wolves, which sit higher on the food chain...
The Weird, Disturbing Origins of the Paleo Diet
Should we all be eating manatees and whales?
As America fights over food, this woman speaks for the unheard
Vanessa Rissetto, a dietician and \
The Best Diet For Brain Health Is Probably Not What You Think
There was one clear, standout winner.
Making Our Own Luck
We are cross-posting a piece that former NIH official Kris Willis wrote for Macroscience. Kris is now the President and Founder of the Woodley Park Institute, for which I’m a board member. Picking winners or hedging bets? Federal science agencies have long wrestled with the question of how to ensure their billions of dollars of grants and contracts result in maximum benefits for Americans. On the surface, it might seem that a goal-oriented, interventionist style of management would be the best policy: prioritize our most pressing problems and distribute funding accordingly.This top-down strategy creates a unique hazard, though: bad choices can send resources in the wrong direction, resulting in slow progress that impedes the delivery of tangible benefits to citizens. Moreover, if decision makers pursue an applied advance when the underlying scientific principles remain poorly understood, they risk costly failures and a loss of support for the research enterprise at large. Examples include Nixon’s 1971 War on Cancer, undertaken on the premise that a cure could be achieved in less than a decade, the drive to build an operational commercial fusion plant by the mid-1990s, and the National Plan to Address Alzheimer’s Disease, which failed to produce the effective treatments and prevention strategies promised by 2025. The contrasting laissez-faire approach is to hedge your bets. If the path to an advance is impossible to predict, then the wisest choice might be to distribute funding to as widely as possible. The main risk of this strategy is that spreading funding thinly may limit the resources available to the most promising research, resulting in the same negative outcomes as the interventionist approach: limited support for the most promising topics, slow progress, and delayed returns. In reality, at science agencies like the National Science Foundation and National Institutes of Health, program managers navigate between these two extremes, setting some funds aside to target high-priority areas and using the rest to cover the widest possible range of meritorious proposals. This middle path seems like the most rational way to proceed, but it still requires making choices. How much should be set aside for high priority topics? What should those topics be? How should we define merit? Expert opinion can provide a helpful guide, but leading experts can have remarkably different opinions about what matters and what should be prioritized. Moreover, experts and administrators alike can be risk averse, giving an edge to high-profile, well-established concepts. What’s really needed is a data-driven framework to help guide decision-making, one that doesn’t simply repackage prestige or incumbency. Recognizing breakthroughs years in advance Many breakthroughs fail to attract funding or recognition at the earliest stages of development. Katalin Karikó, for example, spent years struggling to win grants for work on mRNA that would eventually win her and Drew Weissman a Nobel Prize. Similar stories can be told about Jim Allison’s groundbreaking studies leading to the development of cancer immunotherapy, Stan Pruisner’s demonstration that prions can self-replicate without DNA, or Robin Warren and Barry Marshall’s proof that Helicobacter pylori, not stress, causes ulcers. Yet at some point, the scientific community recognizes and responds to transformative breakthroughs like these. How does that change happen? And what if science funders could identify the areas that are on the cusp of a breakthrough? Those questions led my collaborators and me to study how scientists responded to past breakthroughs. Based on patterns in that data, we developed a means of predicting future breakthroughs, using biomedicine as a proof of concept. It’s worth taking a moment to describe how our approach works. Briefly, our prediction process begins by grouping the 18 million or so peer-reviewed papers in PubMed, the authoritative database of biomedical research, into roughly 50,000 unique topics. A small subset of these topics are so widely acclaimed as breakthroughs that they have been recognized with a major prize like a Nobel or a Lasker Award. We theorized that studying the development of these outliers over time, especially before they gained acclaim, was the key to identifying future instances of them. After defining topics, we chose 21 representative breakthroughs and asked what they looked like before they won prestigious prizes. To answer that question, we re-ran our topic-mapping algorithm repeatedly, winding back the clock one year each time, stringing together the years to follow the progress of each field as it grew and advanced. We found that in each case, the years leading up to a discovery followed a pattern: a burst of papers on a new, rapidly evolving topic, many of which quickly became influential. These characteristics—the percent of papers that are new, the percentage of papers that are brought in from other topics, and the influence of each individual paper—can all be measured separately for any given topic. Together, they act as a predictive signal that is detectable an average of five years before a transformative discovery is made, and up to thirty years before the discovery receives a major prize. Scanning the current research landscape for topics that display this signal allows us to predict what work will likely produce a future breakthrough. Each year we analyzed includes four or five signals, a number that appears to have remained constant across a twenty year time frame. In their classic work on the sociology of science, Bruno Latour and Steve Woolgar established that the desire to participate in a major discovery is an important motivator for scientists as they consider whether they should take up (or abandon) a research problem. Although further work is needed, the simplest explanation for our results is that this behavior is widespread enough to detect at scale. A foundational advance, or something like it, draws the attention of scientists and causes them to change the direction of their research. They vote with their feet, staking their own reputation and careers by publishing on and citing the new idea. That upswell of interest is the foundation of our breakthrough signal. What kind of research does our model identify as a breakthrough? After building a model based on the patterns in our 21 preselected breakthroughs, we tested it by identifying all early signals of discovery from 1994 through 1997. Of the 18 signals we found in that time period, 17 can be traced forward in time to a breakthrough. Examples include super-resolution fluorescence microscopy (see the image above), the directed evolution of proteins and enzymes (Chemistry Nobel, 2018), and sequencing the human genome (National Medal of Science, 2008). The discovery of the role of leptin signaling in obesity is a particularly interesting case study. Around 1950, scientists noticed the existence of a type of lab mouse that suffered from a unique inherited form of obesity. When given the freedom to choose their own diet, these mice ate more than normal and preferred food that was high in fat. Researchers had few clues as to why the animals overate; early experiments pointed to the existence of a soluble ob factor found circulating in the bloodstream that regulated appetite, but its identity was unknown. In 1994, Jeffrey Friedman and colleagues identified and sequenced the ob gene, noting that the protein it encoded appeared to fit the profile of a circulating factor. A year later, a trio of high-profile publications demonstrated that ob was a hormone that regulated body weight and fat deposition by regulating appetite. One of these was co-authored by Friedman, who christened it leptin from the ancient Greek word for thin. Using our model, the data from 1996 make it clear this advance would become a breakthrough. Scientists had flocked to study the biology of the new hormone, generating the flurry of new papers and citations required to produce a signal. One of these demonstrated that serum leptin concentrations reflected the amount of adipose tissue in the human body, providing clinical validation of the earlier mouse studies. Before the identification of leptin, scientists were unable to point to a specific molecule that controlled appetite and adiposity, so that it was impossible to rule out non-physiological causes of obesity; its characterization fundamentally changed our concept of weight gain. In 2010, Friedman and fellow pioneer Douglas Coleman were awarded a Lasker for the discovery. Our work also identifies breakthroughs in clinical practice and behavioral and social sciences, even though these areas are less likely to draw the attention of major prize committees. One example that falls into this category is the introduction of endovascular aneurysm repair, a minimally invasive surgical procedure for the treatment of abdominal aortic aneurysm, a leading cause of death among Americans over the age of 65. Relative to the previous standard of care, it reduces in-hospital mortality by almost four-fold. In 2017, Timothy Chuter received the American College of Surgeons’ prestigious Jacobsen Innovation award for his multiple refinements to the technique. Another under-recognized breakthrough identified by our model is the development of standardized survey instruments to assess the quality of life for HIV+ patients. The antiretroviral cocktails introduced in the mid-1990s reduced AIDS mortality, but treatment came with serious side effects. The new evaluations showed that patients whose disease progressed had worse physical functioning than Americans with other chronic diseases, while those who were asymptomatic maintained a health-related quality of life on par with the overall US population. This evidence made it possible for patients and activists to argue that even in the absence of a total cure, and in spite of the side effects, alleviation of symptoms was a worthwhile priority for clinicians. My colleagues and I have failed to identify any significant recognition for the physicians and health policy experts who pioneered this advance, although in 2016, researchers called for the World Health Organization to set targets for good health-related quality of life as part of its framework to end the AIDS pandemic. From forecasting to funding How should science funders use our predictions? Any serious discussion of what we should do with this new capability needs to begin with an understanding of its limitations. We can’t (and shouldn’t) invest all of our resources in the small number of topics predicted to produce breakthroughs. Innovative new fields are born from existing ones; they rarely arise de novo. If funders don’t maintain a diverse portfolio, the breakthroughs of tomorrow will have no antecedents. Think of this as eating the seed corn, or killing the goose that lays the golden egg. There are also multiple goals of funding beyond basic scientific discovery, including translating discoveries into clinical practice, developing new technologies, supporting economic development, and training new scientists. The investments needed to accomplish these goals are likely different from those required to support emerging breakthroughs. Finally, we must be aware that we may not capture every instance of a breakthrough. The concept is fuzzy, and not every significant discovery is recognized with a major award. Further, breakthroughs are rare, meaning that our dataset is, by necessity, small. This makes formal estimates of accuracy challenging. Although our overall success rate appears to be high, any one signal may turn out to be a false positive. We found one apparent example: the development of the third generation COX-2 inhibitors, Vioxx and Celebrex, which were much celebrated in the early 2000s as effective but non-addictive pain relievers, meets all the algorithmic criteria of a breakthrough. Five years after it received FDA approval, researchers demonstrated that Vioxx was associated with serious cardiovascular complications, and the manufacturer voluntarily pulled the drug from the market. Celebrex remains available, although like other NSAIDs, it carries an FDA warning for increased cardiovascular risk. Decision makers who were overly focused on the breakthrough potential of this research might have wasted substantial resources nurturing an area that ultimately proved to be a failure—but so would those who relied on expert opinion at the time. That said, the potential benefits of funding the next mRNA vaccine or cancer immunotherapy years earlier than we might have are large. When we can’t assume the outcome of an action, it’s worth conducting an experiment. Can targeted support for areas that are poised to produce a breakthrough increase the return on scientific investment without cannibalizing future advances? With the necessary administrative infrastructure in place, conducting this experiment would be straightforward. First, identify all the breakthrough signals between 2018 and 2023, select half at random, and commit to a decade of investment. For biomedicine, a six year window should yield about 30 topics with the potential to produce a breakthrough. Providing strong support to half of these might be accomplished for $300 million a year. That’s roughly half of the recent annual budget of the NIH Common Fund or around 20% of the fiscal year 2025 budget for ARPA-H. After five years, then again at ten, compare to see which group — the one that was actively managed, or the control — produced more breakthroughs, and on what timescale. Although we used biomedicine as an example, the same experiment could just as well be run for physics, materials science, or any other discipline. Any attempt to undertake such an experiment should keep three points top of mind. First, we can predict the topic of future breakthroughs, but the people and vision for how to move the work forward are still important. In practice, this means success requires active program managers with the expertise to develop the science and the authority to do so, including by recruiting investigators. Second, we would be wise to learn from the failures of past attempts to fund transformative research. High among these are funding modestly repackaged work, confusing the genuinely novel with the merely unfamiliar, and relying too much on incumbent investigators. All of these risks can be mitigated by thoroughly and intelligently integrating high quality data into portfolio management. Finally, we need to have patience. Even with strong funding support, producing a breakthrough takes time. If supporting breakthroughs is the best way to nurture the birth of new fields, we also need to accurately describe and properly manage the other two stages, so that we invest wisely throughout the productive lifetime of ideas and divest once they reach the point of diminishing returns. We would benefit from more study of all of these phases, especially the transition from one to another. More research could answer questions like: When does a breakthrough become an established field? How do the availability of funding, the size and characteristics of the available workforce, and the accumulation of evidence that disagrees with prevailing models affect a field’s decline? Exactly how do old ideas give birth to new ones, and can we speed up the process? The more we understand about the dynamics of scientific progress, the better we can maximize the odds that our curiosity leads to results. I’d call that finding a way to make our own luck.
Is it Healthy to Eat Eggs Every Day? Dietitians Weigh In
Eggs are packed with protein, vitamins and omega-3s. But can you eat them every day?
Another look at carrots and eyesight; how to get more fiber; why mosquitoes bite some people and not others; plus other stories with Vanderbilt Health sources
AARP reporter Stacey Colino interviewed Milam Brantley, MD, Associate Professor of Ophthalmology and Visual Sciences, in 2020 for a story about whether eating carrots can improve vision. Sacramento Bee reporter Samantha Agate has now used Brantley’s comments in an AI-curated story created by content specialists on the same topic that has been picked up by MSN and others. Prevention magazine interviewed Heidi Silver, RD, PhD, Founding Director of the Vanderbilt Diet, Body Composition, and Human Metabolism Core, for a story about the importance of fiber and how people can get more of it in their diet. William Schaffner, MD, Professor of Preventive Medicine, was quoted by several news outlets about public health issues, including: Women’s Health (tick bites and alpha-gal syndrome); The Washington Post (tetanus); and Healthline (why mosquitoes prefer to bite some people and leave others alone). A visit to Monroe Carell Jr. Children’s Hospital at Vanderbilt by some Banana Ball baseball players was covered by The Tennessean and WZTV Fox 17 News, and The Tennessean’s story was also picked up by Yahoo! Sports. Clarksville Now published a story written by the Montgomery County Economic Development Team, whointerviewed Bradley Stancombe, MD, professor of Clinical Pediatrics, Vanderbilt Neonatology, about the new energy of Vanderbilt Clarksville Hospital and how the facility is recruiting physicians. Healio Allergy/Asthma group editorial director Richard Gawel interviewed Mark Rolfsen, MD, Clinical Fellow in the Division of Allergy, Pulmonary and Critical Care Medicine, for a story about his presentation at the American Thoracic Society meeting on metal health outcomes following ICU discharge. Nashville Scene reporter Hannah Herner interviewed James Crowe, MD, Director of the Vanderbilt Center for Antibody Therapeutics, for a story about his efforts to prepare for the next pandemic by isolating antibodies that can neutralize dangerous viruses. Medscape reporter Kathleen Doheny interviewed Neesha Choma, Associate Chief of Staff of Vanderbilt University Hospital, for a story about how hospitals can reduce readmissions.
Top supplements Americans use are shifting from multivitamins to targeted health fixes
Dietary supplements are an excellent way to fill gaps in our nutritional requirements. From vitamins and macronutrients to gut-health probiotics, dietary supplements have helped people address deficiencies. ...
Mediterranean-inspired diet with added methionine extends healthy lifespan in mice
A plant- and fish-based, low-protein diet paired with small amounts of an amino acid commonly found in eggs, meat and dairy increased healthy lifespan and decreased frailty and fat mass in mice, according ...
Amino acid-supplemented ‘longevity diet’ linked to longer healthy lifespan
USC study finds low-protein diet paired with small amounts of amino acid methionine increased healthy lifespan, decreased frailty in mice.
Does the War on ‘Ultra-Processed Foods’ Make Any Sense?
The latest dietary evil is an old story in a new package.
8 Probiotic Foods Recommended by a Nutritionist to Support Gut Health
A nutritionist and a registered dietitian share which foods help populate good bacteria in your gut.
One common fat may fuel type 2 diabetes while another helps fight it
Not all fats affect your body the same way. Researchers found that palmitic acid, a saturated fat common in many foods, may contribute to insulin resistance and type 2 diabetes by triggering inflammation, toxic fat buildup, and cellular stress. In contrast, oleic acid—the heart-healthy fat abundant in olive oil—appears to help protect insulin function and may even counter some of the harmful effects of palmitic acid.
6 Canned Foods to Eat to Lower Blood Pressure, According to Dietitians
Canned foods are less expensive than fresh produce and can help you eat more fruits and veggies, which can help lower blood pressure.
Want to Slow Your Aging? Multivitamins, Diet, and Fitness May Help
Recent research has explored the possible effects of diet, daily multivitamins, and cardiorespiratory fitness on aging. Learn about the findings here.
Broccoli vs. Brussels Sprouts: Which Is Healthier?
Broccoli and Brussels sprouts are cruciferous vegetables with high levels of antioxidants. Both can be part of a healthy, balanced diet.
Sugar-Free Diets May Have a Hidden Side Effect, Study in Mice Suggests
But there's a lot we don't know.
Sugar-Free Diets May Have a Hidden Side Effect, Study in Mice Suggests
But there's a lot we don't know.
Sauerkraut diet: Why RFK Jr. eats fermented foods, health benefits
A growing number of men in President Donald Trump's inner circle are eating fermented foods like sauerkraut and yogurt. They can improve gut health.
Sauerkraut diet: Why RFK Jr. eats fermented foods, health benefits
A growing number of men in President Donald Trump's inner circle are eating fermented foods like sauerkraut and yogurt. They can improve gut health.
Zero sugar, more problems? Study reveals surprising gut health effects
A study presented at ENDO 2026 suggests that completely eliminating sugar from a low-fat diet may harm gut health and increase inflammation.
4 High-Fiber Whole Grains for Gut Health, According to Dietitians
Increase your fiber intake by adding these nutritious whole grains to your diet.
Flaxseeds Vs. Hemp Seeds: Which Is Healthier? Dietitian Weighs In
How to choose which healthy seed you should eat.
Mind, Body, Soul: Self-Care Is Health care Community Health Day
Ethan Temple Seventh-day Adventist Church invites residents throughout the Miami Valley and surrounding communities to attend its “Mind, Body, Soul: Self-Care Is Healthcare: Community Health Day” on Saturday, July 25, 2026, at Ethan Temple SDA Church, 4000 Shiloh Springs Road, Clayton, Ohio 45315.The free community event is designed to promote holistic wellness by addressing physical, mental, emotional, and spiritual health while connecting individuals and families with valuable healthcare and community resources.The day opens with Morning Worship at 11:00 a.m., featuring guest speaker Alberta Scruggs, a licensed registered dietitian and nutritionist, who will share practical guidance on nutrition, self-care, and healthy living. Following the service, attendees will enjoy refreshments and a light lunch before taking part in the afternoon's health screenings, community resource fair, and wellness-focused activities.From 2:00 p.m. to 5:00 p.m., attendees will have access to free health screenings provided through a partnership with Premier Health, along with information and resources from local health and human service organizations.A Community Health Fair from 2:00 p.m. to 3:30 p.m. will feature representatives from several organizations such as Black Women’s Health Initiative, CareSource, and many more.Recognizing the growing importance of emotional wellness, the event will also feature a Mental Health Panel Discussion from 3:30 p.m. to 5:30 p.m. led by respected professionals in behavioral health and counseling. The panel will provide an opportunity for open conversation, education, and community engagement around mental health awareness, treatment, and support.In addition to health services and educational opportunities, attendees will receive complimentary lunch bags while supplies last, and school supplies will be distributed to students and families while supplies last.The Community Health Day is open to the public and free of charge. No registration is required.
Eliminating dietary sugar may disrupt gut health and promote inflammation
Eliminating sugar from your diet may be more detrimental than previously thought, according to an animal study being presented Saturday at ENDO 2026, the Endocrine Society's annual meeting in Chicago, Ill.
The Best Time to Take Vitamin E for Better Skin Health
Looking for the best time to take vitamin E for skin health? Dietitians say timing matters less than what you pair it with.
Scientists found a surprising problem with sugar-free diets
A surprising new study suggests that completely eliminating sugar may backfire. Mice on a sucrose-free low-fat diet showed worse blood sugar control, increased inflammation, disrupted gut bacteria, and signs of fatty liver compared with mice that consumed some sucrose. Researchers say the results highlight the importance of a balanced diet and a healthy gut microbiome rather than focusing solely on cutting out sugar.
Prenatal health and early diet may shape fatty liver risk, study suggests
The accumulation of excess fat in the liver is not solely a consequence of the combined effects of hereditary and adult lifestyle-related factors. A new study by researchers at Tampere University and ...
3 Dietitians Share What to Eat Before Every Type of Workout
Learn what to eat before strength training, running, HIIT, and yoga, plus expert tips on when to fuel for better performance.