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Poll: Most Americans think the U.S. has strayed from its founding principles
Most Americans believe the country has moved away from its founding principles as the nation prepares for its big 250th anniversary, a new PBS News/NPR/Marist poll finds. Eighty-three percent of U.S. adults feel America has strayed from the ideals the country was founded on two-and-a-half centuries ago. Among them, close to half of Americans — 47% — say the U.S. has "moved far away" from these principles, joined by 36% who said America has “moved
Multiple NFL teams ‘join’ LeBron James sweepstakes amid Lakers exit
LeBron James’ decision to move on from the Los Angeles Lakers grabbed headlines. Several NBA teams have been linked to him, but NFL franchises also joined in with their “pitches.” The Buffalo Bills, New York Jets, Houston Texans and Green…
Leaders of powerful S.F. Chinatown business group threaten to quit
Some leaders of San Francisco’s Chinese Chamber of Commerce are demanding that former president Donald Luu be permanently removed from the organization’s board.
Weiser wins Colorado Democratic governor primary race over Bennet
NBC News projects that Weiser will move on to the general election after defeating Bennet, who has served in the Senate for 17 years.
Wilmington Small Business Coalition: Building Momentum in 2026 by Heather McWhorter
This article was contributed by Lydia Thomas, UNCW CIE Program Manager. North Carolina continues to be one of the best states to start a business and in 2025, Wilmington, North Carolina earned a spot on the GoDaddy list of the top 10 most entrepreneurial cities in the U.S. While many know Wilmington as small beach town with exceptional food, lots of coffee shops, and fun, vibrant summer activities, a closer look reveals a thriving innovation economy. You’ll find startups emerging across industries including software, healthtech, bluetech, and fintech. At the core of this entrepreneurial ecosystem is the Wilmington Small Business Coalition, with small business advocates and entrepreneur support organizations (ESOs) dedicated to helping founders grow, thrive, and succeed. “No Wrong Door” Established in 2016, the Coalition was designed to make it easier for individuals and small businesses to access resources most suited to their particular needs. The Coalition is designed to have a “no wrong door” entryway into the regional startup ecosystem. Whether you are exploring a new idea sketched on the back of a napkin or leading a more established, growth-stage company, Coalition members can help connect you with the programs, funding opportunities, mentors, and resources best suited to your needs. No matter where you are in your entrepreneurial journey, any Coalition organization can help point you in the right direction. Coalition Members and Leadership Coalition members include the UNCW Center for Innovation and Entrepreneurship (UNCW CIE), AARP, Brunswick Community College Small Business Center, Cape Fear Community College Small Business Center, Cape Fear Region SCORE, Genesis Block Foundation, Network for Entrepreneurs in Wilmington (NEW), Small Business & Technology Development Center (SBTDC), Greater Wilmington Chamber of Commerce, YWCA Living the Dream Center for Entrepreneurship, Carolina Community Impact Fund (CCI Fund), Partner Community Capital, 717mkt Office Collaborative, NC Biotech, and Institute NC. In May 2026, the Coalition held its leadership elections, resulting in the selection of a new executive team. The following officers were elected to serve two-year terms: Chair: Lydia Thomas, UNCW CIE Vice Chair: Diane Lantz, CCI Fund Secretary: Aariene Hansley, Genesis Block Foundation Treasurer: Gloria Monroe, SBTDC Vision for the Wilmington Small Business Coalition In 2026, the Wilmington Small Business Coalition continues its work as a collaborative network of organizations. By connecting programs, expertise, and services across partner organizations, entrepreneurs can more easily find the right support at the right time. Rather than operating in silos, the Coalition aims to function as a unified, cohesive system of support for small businesses and entrepreneurs, ensuring that resources and expertise across partner organizations are visible and accessible. Through stronger collaboration and shared pathways, entrepreneurs can move more seamlessly from idea to startup to growth. Looking to dive into the Wilmington entrepreneurial ecosystem? Connect with any of the Coalition partners to get started! Connect with CIE To learn more about CIE and our services, programs, and events, join the CIE newsletter. You can also follow us on social media: Instagram, Facebook, LinkedIn, TikTok, or YouTube. CIE’s website is uncw.edu/cie. Heather McWhorter is the director of the UNCW Center for Innovation and Entrepreneurship (CIE). CIE supports innovation-forward start-ups and helps to build a vibrant innovation economy for all in southeast NC.
Riley Gaines and MyKayla Skinner send message to Simone Biles on women's sports debate after SCOTUS ruling
Riley Gaines and MyKayla Skinner celebrate the Supreme Court transgender athletes ruling and call on Simone Biles to join their movement.
Shohei Ohtani pitching start moved to Friday vs. Padres
Fresh arm express: Wyatt Mills called up, Jonathan Hernández DFA’d
Pacific Engineering Inc. to become first tenant at Omaha Airport Business Park
The first business has made reservations to move into the Airport Business Park.
Pacific Engineering Inc. to become first tenant at Omaha Airport Business Park
The first business has made reservations to move into the Airport Business Park.
LeBron On The Move
For the last few years, LeBron James’ name has popped up as someone who might be on the move in the NBA off-season. But few truly believed the future Hall of Famer would actually bolt from the Los Angeles Lakers. Now, it appears he actually won’t be playing for the Lakers in 2026-27. The source: ...
Jacobs Entertainment moves ahead with sign along I-80, seeks approval for two skywalks
Jacobs Entertainment plans to build a neon sign and skyways in Reno's Neon Line District, aiming to enhance pedestrian safety and attract visitors.
Kawhi Leonard reportedly traded back to Raptors as Clippers move on from star forward
The Kawhi Leonard era is over with the Clippers.
Trump administration suspends funding for New York's Medicaid fraud unit
The move is the second suspension of a state Medicaid fraud unit this year by the Republican Trump administration.
BWF unveils 2027-28 calendar; India Open moves to February next year: Indian Sports LIVE, June 30
Here are all the updates from Indian sports on June 30, 2026.
Gorsuch suggests Supreme Court's Trump ruling is opening move against administrative state
Justice Neil Gorsuch's concurrence suggests the Supreme Court's FTC ruling could lead to sweeping challenges against independent federal agencies' power.
Business is good at the Camillus Costco. It asks town for OK to make a move
The proposal is being reviewed by the town of Camillus planning board.
Round table: Manufacturing Revoultion
••• SPONSORED SECTION ••• Manufacturing historically has conjured a certain perception, one of low skills, low pay and low advancement. But times are changing, and they’re changing fast. Spurred by North Carolina’s often lauded economic environment, manufacturers from a variety of sectors are advancing, investing and expanding across the state. But those moves come with […]
Three AirDrop vulnerabilities discovered, with Apple working on a full fix
Three AirDrop vulnerabilities have been discovered by security researchers, affecting both iPhone and Mac, with similar ones found in Android’s...
The next test of the democratic socialist movement and other key races to watch in Colorado’s primaries
Democratic rifts over ideology, generation change and how best to take on President Donald Trump will be on display Tuesday in Colorado, as voters settle primaries for governor and a key House race, weigh ousting two mainstays of the state’s Democratic landscape and more.
Grand Theft Auto workers seek union recognition after mass firings
Exclusive: Staff at Rockstar Games hope move can be completed before release of GTA VI scheduled for November
Editorial: Chicago separated its mental health emergency response from public safety. Bad idea.
Johnson’s redesign moved CARE toward a stand-alone public health response rather than an integrated public safety partnership.
Chelsea's George close to permanent Everton move
Everton close in on a deal to sign Chelsea winger Tyrique George following his loan spell.
Colorado’s workers can’t afford a decline in tourism
By Terrance Carroll Work is about more than a paycheck. It is about dignity, stability and the ability to build a life, to provide for family, to contribute to community, and to move forward with purpose. That is why we should take a closer look at how federal policy decisions, even those made with good […]
Oil markets move from fearing shortages to worrying about surpluses
Global oil supply recovery eases shortage fears as Brent crude falls to $73. Wall Street is lowering forecasts amid demand concerns.
Apple Is Moving The iPhone 18 Pro’s IR Flooder To The Side, As A CT Scan Exposes A Huge Vapor Chamber Stretching To The Top, And A Smaller Dynamic Island
Apple has moved iPhone 18 Pro's infrared flooder to the side, while housing the front camera and the Face ID scanner within a smaller cutout.
England to get powerful maternity commissioner after ‘shocking’ failings
Health secretary announces move after Amos review finds childbirth and neonatal care in need of ‘urgent reform’
Palmetto Sports Daily: Hornets make big moves, 4th of July food draft begins
The crew has more on the Charlotte Hornets’ big offseason moves, including the trades of both LaMelo Ball and Miles Bridges.
Takeaways from the Supreme Court’s decisions expanding Trump’s firing power but preserving Fed for now
The Supreme Court handed President Donald Trump a significant win Monday by allowing him to remove the leaders of once-independent federal agencies at will, toppling a 1935 precedent in the process that could reorder the way the government functions.
How Mississippi reacted to the Supreme Court mail-in ballot ruling
In a rare move out of lockstep with President Trump, the U.S. Supreme Court backed Mississippi's law counting mail-in ballots after Election Day.
Scientists Slam Trump Rule Change
Dr. Esen Sefik moved from Istanbul to New Haven 20 years ago because she believed the U.S. was the best place to do scientific research. Now, her advisees are wondering whether to stay in their home countries instead. Sefik described the U.S.'s changing research climate on Monday during a press conference about a proposed rule by the Trump administration that would require a political appointee to approve all discretionary federal grants.
Supreme Court: Trump may fire heads of independent agencies, but not the Federal Reserve
The court's conservatives said the president had the authority to remove all officials who wield executive authority, even if the agency officials had fixed terms set by law.
Supreme Court rules MSU economist Lisa Cook can remain as Fed governor
The Trump administration sought to remove Fed governor Lisa Cook amid a push to get the U.S. independent central bank to lower interest rates.
Seaport downgrades MSG Entertainment stock rating to neutral
Seaport downgrades MSG Entertainment stock rating to neutral
America @ 250: Alex Wysocki asks, ‘Are short-term political gains worth giving up the big picture?’
Alex Wysocki is a television producer, filmmaker, husband and father of three. He and his wife Abigail moved to Champaign during the COVID-19 pandemic and are raising their family here.
Full Court Orlando Magic Short Thoughts: Jonathan Isaac is Waived
The Orlando Magic have moved off longtime defensive specialist Jonathan Isaac.
The Anti-Data-Center Movement Is Reshaping Michigan Politics
Climate activist Will Lawrence cofounded the Sunrise Movement. Now, he has shifted his focus in his attempt to compete for a swing-district seat by calling for a data center moratorium.
Comcast to split into two companies, spin off NBCUniversal and Sky
The move announced Monday will separate Comcast’s media and entertainment assets from its broadband and wireless business.
Rural Fosston moves forward in its quest to relinquish control of local hospital from Essentia Health
A northwestern Minnesota community is seeking to regain local control of its hospital, arguing Essentia Health has failed to meet local health care needs. A recent court ruling allows Fosston to take its case to arbitration.
Report: Chelsea to make move for La Liga defender
Chelsea Monitor Pep Chavarría as Left Back OptionChelsea Explore Fresh Defensive OptionChelsea’s search for greater depth at left back appears to have taken them to Spain, with Marca reporting that...
Lewandowski close to Chicago Fire switch
Poland's record scorer is set for a big-money move to the MLS after his departure from Barcelona.
Reports: Diomande agrees PSG move from Leipzig
Ivory Coast forward Yan Diomande has decided to leave RB Leipzig for Paris Saint-Germain, according to media reports. Broadcasters Sky and RMC, as well as transfer specialist Fabrizio Romano, reported on Sunday that the 19-year-old has agreed a five-year contract with the French Champions League winners.
Warriors pursuing LeBron James and Anthony Davis? Kawhi Leonard on the move? Here's the latest trade chatter
Bickley: It's hard to root for Suns, Miles Bridges pairing
You knew Suns owner Mat Ishbia would make a move this offseason, but trading for Miles Bridges could risk toppling the franchise's new identity.
AI could unleash ‘single greatest productivity revolution’ if Washington avoids overreach: report
The Unleash Prosperity report, titled "Boomsday Not Doomsday," argues AI could help ease housing costs, boost productivity and move workers into higher-value roles.
Prediction market Kalshi sues Illinois over its push to regulate sports bets
The most recent move in the ongoing legal battle between the state and prediction market operators came after the state enacted new sports wagering taxes to support the $55.9 billion budget it passed this spring.
Health insurers are looking for MAHA wins
The companies are offering benefits aimed at appealing to Robert F. Kennedy Jr. and his Make America Healthy Again movement.
Bills decline to honor O.J. Simpson in making the move to new stadium
Simpson died two years ago, and his reputation became forever stained by charges that he killed his former wife and her male friend in 1994.
Penguins organizational outlook heading into free agency
It ended up being a mostly uneventful draft weekend for the Pittsburgh Penguins. They acquired Hendrix Lapierre for draft picks, used some of their stockpile future of picks to get extra 2026 mid-round selections and went about their business of drafting players without many fireworks going down with massive moves. The big landmark for the […]
🚨 BREAKING: Robert Lewandowski agrees multi-year deal with Chicago Fire
Major League Soccer looks set to add another iconic veteran presence to its ranks this summer, with Polish legend Robert Lewandowski reportedly primed for a move to Chicago Fire.Per The Athletic, the ...
US Small and Midsize Businesses Poised for Growth, Waiting to Make Significant Moves: 2026 Columbia Bank Business Barometer
Rising expectations for increased productivity, profitability and growth opportunities tempered by near-term uncertainty and volatility
Lille reveal Ayyoub Bouaddi stance amid Liverpool interest
Liverpool Face Patient Lille Stance Over Ayyoub Bouaddi TransferLiverpool’s interest in Ayyoub Bouaddi has moved into sharper focus, with AS reporting that Lille are prepared to take a patient appro...
US Small and Midsize Businesses Poised for Growth, Waiting to Make Significant Moves: 2026 Columbia Bank Business Barometer
US small and midsize businesses are poised for growth but are waiting to make significant moves reports the Columbia Bank Business Barometer
England will miss Stokes' winning persona
Former England captain Michael Vaughan reflects on Ben Stokes' shock retirement and how the team can move on from one of their "greatest" players.
France, Argentina top World Cup odds; U.S. puts sportsbooks at risk
Star-powered France and Argentina top the odds board to win the World Cup as the tournament moves into the knockout stage, while the United States' positive momentum will have sportsbooks sweating more with each game it wins.
Rescheduling marijuana would put politics ahead of science
The Drug Enforcement Administration is considering a proposal to move marijuana from Schedule I to Schedule III of the Controlled Substances Act, which would recognize all cannabis products as havi…
Rescheduling marijuana would put politics ahead of science
The Drug Enforcement Administration is considering a proposal to move marijuana from Schedule I to Schedule III of the Controlled Substances Act, which would recognize all cannabis products as havi…
Sony’s New Blu-ray & DVD Player Upscales DVDs to Near-HD Quality - Bring Your Old DVDs To Life Again
In a time when streaming services continue to raise prices, fragment content libraries, remove content, and push intrusive ads, many households are rediscovering the reliability and ownership of physical DVDs and Blu-rays. Sony has answered this shift with the release of its latest affordable disc player: the Sony BDP-S1700U. Priced at just $114.99, this sleek […]
Common pesticide linked to more than double the risk of Parkinson’s disease
Scientists at UCLA have linked long-term exposure to the pesticide chlorpyrifos with a sharply increased risk of Parkinson’s disease. People exposed to the chemical near their homes were more than twice as likely to develop the condition. Laboratory studies showed that chlorpyrifos damages dopamine neurons and interferes with the brain’s ability to remove toxic protein buildup.
My 2 sons moved back in with me; my expenses have gone up
My two sons still live with me so they can save on housing costs. That means my expenses have gone up, like electricity and grocery budgets.
Progressives look to Colorado as next test of a rising movement
Melat Kiros, a 29-year-old democratic socialist and lawyer, is challenging 15-term Rep. Diana DeGette for a solidly blue seat in Denver, where she and her allies hope voters are ready for change.
The great FIRE debate: People who made it work say critics miss the point
"I don't live in a van, eat rice and beans, and I've never given up traveling," said one early retiree. "That's not what the movement is about."
Winner and Loser of the Week in Florida politics
FDACS moves fast on the mealybug threat, while Ye's Tampa concerts proceed despite pushback.
Magnetic sperm and the ugliest shark: science stories of the week
From a lupus breakthrough to why humans naturally move anticlockwise, here are the most interesting scientific developments of the week
Report: Crystal Palace Eye Smart Move for Experienced Arsenal Midfielder
Crystal Palace Eye Christian Norgaard as Arsenal Exit Route OpensPalace Consider Midfield ExperienceCrystal Palace appear ready to offer Christian Norgaard a route out of Arsenal this summer, with Spo...
Starz Entertainment (STRZ) Stock Sees Fair Value Lift After Q1 Analyst Target Increases
Price targets for Starz Entertainment have shifted as the analyst fair value estimate moved from US$19.38 to US$28.50, putting a higher reference point in focus for investors tracking the stock. Recent Street research has turned more constructive after the Q1 report, with several firms lifting price targets and updating models to reflect how they now view execution risks and valuation support. In the sections that follow, you will see how to interpret these changing targets and what they...
PlayStation is pulling "previously purchased" digital movies from users' libraries
Sony has written to customers to advise that hundreds of "previously purchased" digital movies previously available via its online store will "be removed".
Biggest offseason question for every West team: Big moves for Lakers, Warriors? Can Spurs trade De'Aaron Fox?
Will LeBron James stay in Los Angeles? What's next for Ja Morant and Kawhi Leonard?
FISU reinforces its commitment to the World University Sports Movement
On the second day of the meeting, the Executive Committee focused on the upcoming Universiades and the future of the FISU Forum. After a first day concentrating on updating statutes and strategies for a simpler, more innovative and effective future, FISU’s Executive Committee focused on upcoming events on this second and last day of their […]
I moved to Canada and couldn't find a job; I started my art business
When I moved to Canada, I couldn't land a job for months. I started drawing illustrations and posted them on social media. People wanted to buy them.
The NHL's Obsession With No-Trade Clauses: Why Hockey Is The Outlier In North American Sports
No-trade and no-move clauses have become so commonplace in the NHL that many fans assume they are simply part of the business of sports. They aren’t.
Trump tamped down fights over abortion and marriage. Conservative activists want to bring them back in 2028
Since returning to the White House, Trump has largely sidestepped causes long championed by the conservative faith movement
Former Giannis Role Players Now On Milwaukee Bucks Trading Block
The Milwaukee Bucks are turning the page to a new chapter in their franchise following the trade of Giannis Antetokounmpo to the Milwaukee Bucks. Along with opening a new era, the Bucks are also looking to move on from some of their role players during the team’s Giannis phase. Among them are Kyle Kuzma and […] The post Former Giannis Role Players Now On Milwaukee Bucks Trading Block appeared first on HEAVY.
Ducks move into first round, select skill in Klepov, Nordmark
Anaheim jumped back into the first-round with two picks acquired in the Mason McTavish deal, and the Ducks went for scoring punch in Nikita Klepov and Marcus Nordmark.
Nigel Farage’s anti-WHO campaign moves to US with allies added to board
Relocation of Action on World Health raises questions over why Reform UK leader is involved in a US pressure group
Nigel Farage’s anti-WHO campaign moves to US with allies added to board
Relocation of Action on World Health raises questions over why Reform UK leader is involved in a US pressure group
Luca Marini negotiating move to Tech3 KTM for 2027
Marini could now join Tech3 as Vinales' chances of retaining his seat vanish
Mo Salah moves closer to €80m contract deal
Following a poor campaign - both individually and collectively - the Egyptian King reached an agreement to rip up his £400k per week contract one year early.The 34-year-old is currently strutting his...
4 AI Prompts to Build a Profitable One-Person Business in 2026 (The Part Every AI Influencer Skips)
Spot the one move every AI influencer skips — and turn it into your next multimillion-dollar business.
Lawmakers say White House demolition debris at East Potomac Park poses health risk
Democratic lawmakers are urging the Trump administration to remove demolition debris from East Potomac Park Golf Course, citing health concerns, while the administration says the site poses no public health risk.
What if the economy gets better and it doesn’t help the GOP?: From the Politics Desk
Plus, Gavin Newsom’s next move in the billionaire tax fight.
White House mandates move away from overdose prevention in US health programs
Experts say move signals greater political interference into public health and will exacerbate opioid overdose crisis
Dell shareholders approve legal move from Delaware to Texas
Michael Dell says Texas is where the company has always belonged as shareholders overwhelmingly approve the reincorporation move from Delaware.
PlayStation Is Deleting Terminator 2 And 550 Other Movies
Movies like Rambo: First Blood, Bridget Jones' Diary and The Deer Hunter are all being unceremoniously removed
State Sen. Ben Gilmore’s latest move shows politics is more chess than checkers
Politics is full of exits. Some are dramatic. Some are unexpected. And then there are the ones that remind you politics is less like a race and more like chess—
Remigration: a growing far-right movement
Once a fringe position, calls for mass deportation are spreading throughout Europe and entering mainstream politics
Cutting costs to move forward: SoFi State of Small business 2026 survey
SoFi reports 86% of small business owners see growth or stability, yet 66% cite high costs, mainly inflation and interest rates, as major challenges.
Cutting costs to move forward: SoFi State of Small business 2026 survey
SoFi reports 86% of small business owners see growth or stability, yet 66% cite high costs, mainly inflation and interest rates, as major challenges.
Old Town Moves Forward With Business Improvement District
City supports effort to strengthen historic district
Sweden and WHO launch new long-term initiative to transform Ukraine’s health system
WHO and the Swedish International Development Cooperation Agency (Sida) have launched a new multi-year cooperation project to support the long-term recovery and transformation of Ukraine’s health system. The new project, “Ukraine’s Health System Transformation Initiative: Strengthening Health Governance, Health Financing and Service Delivery for Long-Term Recovery”, was launched at the Ukraine Recovery Conference 2026 in Gdansk, Poland on 26 June, and will run from June 2026 to 2029. Sweden will contribute approximately US$ 26 million (240 million Swedish krona) to support this project. This contribution forms part of Sweden’s broader support to Ukraine through the Team Europe approach, which brings together the European Union, its Member States, and key partners such as the European Commission’s Directorate-General for Enlargement and Eastern Neighbourhood and Enabel, and WHO as lead health agency, to support Ukraine’s recovery, reform agenda and European integration.“Ukraine’s health recovery cannot be measured only by what is rebuilt, but by whether people can count on the health system when they need it most. The scale of the task is immense, with health reconstruction and modernization needs estimated at US$ 19.4 billion over the next decade. Sweden’s US$ 26 million contribution to Ukraine’s Health System Transformation Initiative is a timely investment in the institutions, financing and services that will support Ukraine’s long-term recovery and European integration. WHO remains a trusted partner of the Government of Ukraine in advancing this process. I am deeply grateful to Sweden for its consistent support and partnership,” said Dr Hans Henri P. Kluge, WHO Regional Director for Europe. More than 4 years of war have placed unprecedented pressure on Ukraine’s health system, creating 3 interconnected challenges. The first is responding to the immediate consequences of the war and the urgent health needs of the population. The second is recovering and modernizing health services today. The third is continuing reforms and aligning the health system with European standards in the context of Ukraine’s future accession to the European Union. The war has led to large-scale population displacement, an increasing need for trauma care and rehabilitation, and shortages of health workers. High out-of-pocket payments in Ukraine make access to health services more difficult. Around 46% of total health expenditure is paid directly by individuals, placing a significant financial burden on many households and underscoring the need for reforms in health financing. Older people, persons with disabilities, women, children and veterans continue to face the greatest difficulties in accessing health services. “Ukraine is demonstrating that health system transformation can continue even during war. Ukraine is also continuing to align its health system with European norms and standards. WHO is committed to supporting Ukraine on this journey. We provide technical support, help coordinate partners’ efforts and support the institutional changes needed to strengthen the system. We are grateful to Sweden for its support. Through this partnership, we can help Ukraine build a more resilient, accessible and people-centred health system,” said Dr Jarno Habicht, WHO Representative in Ukraine. About the Health System Transformation InitiativeThe new initiative will support Ukraine through 3 interconnected areas: strengthening governance and coordination of health sector reforms through more inclusive coordination platforms and structured policy dialogue; transforming service delivery by reinforcing a primary health care-centred model that integrates family medicine, nursing and midwifery; and improving financial sustainability by supporting reforms that ensure the long-term viability of the national health system and reduce out-of-pocket payments for households. Overall, these reforms are expected to make the health system more coherent and easier to navigate, improve the quality and continuity of care, and ensure more equitable access to services, particularly for those who need them most. They will also support Ukraine’s progress towards a more modern health system aligned with European standards. “We are convinced that long-term recovery is not possible without strong, high-quality, person-centred health services that are accessible to everyone. Our partnership with WHO is designed to support deep and lasting systemic changes. Investments in human capital especially autonomous midwives, whose role for maternal, newborn and adolescent sexual and reproductive health cannot be understated, stronger governance, digital transformation and the financial sustainability of the health system are investments in Ukraine’s future. We are proud to support this process,” said Malin Perhult, the Head of the Ukraine Unit at Sida. Focus throughout implementation will be given to the most vulnerable population groups, including older people, women and children, and persons with disabilities, who have been affected by the war and face greater health-care needs. The initiative will be implemented in close cooperation with the Ministry of Health of Ukraine, the National Health Service of Ukraine, the Public Health Centre of Ukraine, regional authorities and international partners. This project will help Ukraine move towards a system where everyone can access the health care they need. It will strengthen primary care, make the health finance system more stable and predictable, and reduce the out-of-pocket costs that Ukrainians face when using health services. As a result, the Ukrainian health system will become more aligned with European standards and more sustainable in the long run.
PlayStation Boss Says New Console Experiences Will Involve 'Leveraging Technologies That Can Be Used in Various Forms and Locations' — and I'm Convinced He's Teasing a PS6 Handheld
Recent comments from Sony Interactive Entertainment CEO Hideaki Nishino have suggested PlayStation may move towards more hybrid, Switch-like consoles in the future to match modern on-the-go players.
Introducing: Breguet Celebrates the 225th Anniversary of the Tourbillon with Four New Releases, And the Return of a Collector Favorite (Live Pics)
A revived and revised version of the Roth-designed caliber 558.1 movement (significantly improved) headlines four watches to celebrate the patent date of one of Abraham-Louis Breguet's most notable achievements.
Injury-hit Warrington dig deep to beat Catalans
Warrington overcome injury problems to move level on points with Leeds at the top of Super League with a gutsy win over Catalans.
Project manager says America’s Time Capsule is a ‘gift to the future’
The vessel will move from Washington to Philadelphia starting Friday.
Making Our Own Luck
We are cross-posting a piece that former NIH official Kris Willis wrote for Macroscience. Kris is now the President and Founder of the Woodley Park Institute, for which I’m a board member. Picking winners or hedging bets? Federal science agencies have long wrestled with the question of how to ensure their billions of dollars of grants and contracts result in maximum benefits for Americans. On the surface, it might seem that a goal-oriented, interventionist style of management would be the best policy: prioritize our most pressing problems and distribute funding accordingly.This top-down strategy creates a unique hazard, though: bad choices can send resources in the wrong direction, resulting in slow progress that impedes the delivery of tangible benefits to citizens. Moreover, if decision makers pursue an applied advance when the underlying scientific principles remain poorly understood, they risk costly failures and a loss of support for the research enterprise at large. Examples include Nixon’s 1971 War on Cancer, undertaken on the premise that a cure could be achieved in less than a decade, the drive to build an operational commercial fusion plant by the mid-1990s, and the National Plan to Address Alzheimer’s Disease, which failed to produce the effective treatments and prevention strategies promised by 2025. The contrasting laissez-faire approach is to hedge your bets. If the path to an advance is impossible to predict, then the wisest choice might be to distribute funding to as widely as possible. The main risk of this strategy is that spreading funding thinly may limit the resources available to the most promising research, resulting in the same negative outcomes as the interventionist approach: limited support for the most promising topics, slow progress, and delayed returns. In reality, at science agencies like the National Science Foundation and National Institutes of Health, program managers navigate between these two extremes, setting some funds aside to target high-priority areas and using the rest to cover the widest possible range of meritorious proposals. This middle path seems like the most rational way to proceed, but it still requires making choices. How much should be set aside for high priority topics? What should those topics be? How should we define merit? Expert opinion can provide a helpful guide, but leading experts can have remarkably different opinions about what matters and what should be prioritized. Moreover, experts and administrators alike can be risk averse, giving an edge to high-profile, well-established concepts. What’s really needed is a data-driven framework to help guide decision-making, one that doesn’t simply repackage prestige or incumbency. Recognizing breakthroughs years in advance Many breakthroughs fail to attract funding or recognition at the earliest stages of development. Katalin Karikó, for example, spent years struggling to win grants for work on mRNA that would eventually win her and Drew Weissman a Nobel Prize. Similar stories can be told about Jim Allison’s groundbreaking studies leading to the development of cancer immunotherapy, Stan Pruisner’s demonstration that prions can self-replicate without DNA, or Robin Warren and Barry Marshall’s proof that Helicobacter pylori, not stress, causes ulcers. Yet at some point, the scientific community recognizes and responds to transformative breakthroughs like these. How does that change happen? And what if science funders could identify the areas that are on the cusp of a breakthrough? Those questions led my collaborators and me to study how scientists responded to past breakthroughs. Based on patterns in that data, we developed a means of predicting future breakthroughs, using biomedicine as a proof of concept. It’s worth taking a moment to describe how our approach works. Briefly, our prediction process begins by grouping the 18 million or so peer-reviewed papers in PubMed, the authoritative database of biomedical research, into roughly 50,000 unique topics. A small subset of these topics are so widely acclaimed as breakthroughs that they have been recognized with a major prize like a Nobel or a Lasker Award. We theorized that studying the development of these outliers over time, especially before they gained acclaim, was the key to identifying future instances of them. After defining topics, we chose 21 representative breakthroughs and asked what they looked like before they won prestigious prizes. To answer that question, we re-ran our topic-mapping algorithm repeatedly, winding back the clock one year each time, stringing together the years to follow the progress of each field as it grew and advanced. We found that in each case, the years leading up to a discovery followed a pattern: a burst of papers on a new, rapidly evolving topic, many of which quickly became influential. These characteristics—the percent of papers that are new, the percentage of papers that are brought in from other topics, and the influence of each individual paper—can all be measured separately for any given topic. Together, they act as a predictive signal that is detectable an average of five years before a transformative discovery is made, and up to thirty years before the discovery receives a major prize. Scanning the current research landscape for topics that display this signal allows us to predict what work will likely produce a future breakthrough. Each year we analyzed includes four or five signals, a number that appears to have remained constant across a twenty year time frame. In their classic work on the sociology of science, Bruno Latour and Steve Woolgar established that the desire to participate in a major discovery is an important motivator for scientists as they consider whether they should take up (or abandon) a research problem. Although further work is needed, the simplest explanation for our results is that this behavior is widespread enough to detect at scale. A foundational advance, or something like it, draws the attention of scientists and causes them to change the direction of their research. They vote with their feet, staking their own reputation and careers by publishing on and citing the new idea. That upswell of interest is the foundation of our breakthrough signal. What kind of research does our model identify as a breakthrough? After building a model based on the patterns in our 21 preselected breakthroughs, we tested it by identifying all early signals of discovery from 1994 through 1997. Of the 18 signals we found in that time period, 17 can be traced forward in time to a breakthrough. Examples include super-resolution fluorescence microscopy (see the image above), the directed evolution of proteins and enzymes (Chemistry Nobel, 2018), and sequencing the human genome (National Medal of Science, 2008). The discovery of the role of leptin signaling in obesity is a particularly interesting case study. Around 1950, scientists noticed the existence of a type of lab mouse that suffered from a unique inherited form of obesity. When given the freedom to choose their own diet, these mice ate more than normal and preferred food that was high in fat. Researchers had few clues as to why the animals overate; early experiments pointed to the existence of a soluble ob factor found circulating in the bloodstream that regulated appetite, but its identity was unknown. In 1994, Jeffrey Friedman and colleagues identified and sequenced the ob gene, noting that the protein it encoded appeared to fit the profile of a circulating factor. A year later, a trio of high-profile publications demonstrated that ob was a hormone that regulated body weight and fat deposition by regulating appetite. One of these was co-authored by Friedman, who christened it leptin from the ancient Greek word for thin. Using our model, the data from 1996 make it clear this advance would become a breakthrough. Scientists had flocked to study the biology of the new hormone, generating the flurry of new papers and citations required to produce a signal. One of these demonstrated that serum leptin concentrations reflected the amount of adipose tissue in the human body, providing clinical validation of the earlier mouse studies. Before the identification of leptin, scientists were unable to point to a specific molecule that controlled appetite and adiposity, so that it was impossible to rule out non-physiological causes of obesity; its characterization fundamentally changed our concept of weight gain. In 2010, Friedman and fellow pioneer Douglas Coleman were awarded a Lasker for the discovery. Our work also identifies breakthroughs in clinical practice and behavioral and social sciences, even though these areas are less likely to draw the attention of major prize committees. One example that falls into this category is the introduction of endovascular aneurysm repair, a minimally invasive surgical procedure for the treatment of abdominal aortic aneurysm, a leading cause of death among Americans over the age of 65. Relative to the previous standard of care, it reduces in-hospital mortality by almost four-fold. In 2017, Timothy Chuter received the American College of Surgeons’ prestigious Jacobsen Innovation award for his multiple refinements to the technique. Another under-recognized breakthrough identified by our model is the development of standardized survey instruments to assess the quality of life for HIV+ patients. The antiretroviral cocktails introduced in the mid-1990s reduced AIDS mortality, but treatment came with serious side effects. The new evaluations showed that patients whose disease progressed had worse physical functioning than Americans with other chronic diseases, while those who were asymptomatic maintained a health-related quality of life on par with the overall US population. This evidence made it possible for patients and activists to argue that even in the absence of a total cure, and in spite of the side effects, alleviation of symptoms was a worthwhile priority for clinicians. My colleagues and I have failed to identify any significant recognition for the physicians and health policy experts who pioneered this advance, although in 2016, researchers called for the World Health Organization to set targets for good health-related quality of life as part of its framework to end the AIDS pandemic. From forecasting to funding How should science funders use our predictions? Any serious discussion of what we should do with this new capability needs to begin with an understanding of its limitations. We can’t (and shouldn’t) invest all of our resources in the small number of topics predicted to produce breakthroughs. Innovative new fields are born from existing ones; they rarely arise de novo. If funders don’t maintain a diverse portfolio, the breakthroughs of tomorrow will have no antecedents. Think of this as eating the seed corn, or killing the goose that lays the golden egg. There are also multiple goals of funding beyond basic scientific discovery, including translating discoveries into clinical practice, developing new technologies, supporting economic development, and training new scientists. The investments needed to accomplish these goals are likely different from those required to support emerging breakthroughs. Finally, we must be aware that we may not capture every instance of a breakthrough. The concept is fuzzy, and not every significant discovery is recognized with a major award. Further, breakthroughs are rare, meaning that our dataset is, by necessity, small. This makes formal estimates of accuracy challenging. Although our overall success rate appears to be high, any one signal may turn out to be a false positive. We found one apparent example: the development of the third generation COX-2 inhibitors, Vioxx and Celebrex, which were much celebrated in the early 2000s as effective but non-addictive pain relievers, meets all the algorithmic criteria of a breakthrough. Five years after it received FDA approval, researchers demonstrated that Vioxx was associated with serious cardiovascular complications, and the manufacturer voluntarily pulled the drug from the market. Celebrex remains available, although like other NSAIDs, it carries an FDA warning for increased cardiovascular risk. Decision makers who were overly focused on the breakthrough potential of this research might have wasted substantial resources nurturing an area that ultimately proved to be a failure—but so would those who relied on expert opinion at the time. That said, the potential benefits of funding the next mRNA vaccine or cancer immunotherapy years earlier than we might have are large. When we can’t assume the outcome of an action, it’s worth conducting an experiment. Can targeted support for areas that are poised to produce a breakthrough increase the return on scientific investment without cannibalizing future advances? With the necessary administrative infrastructure in place, conducting this experiment would be straightforward. First, identify all the breakthrough signals between 2018 and 2023, select half at random, and commit to a decade of investment. For biomedicine, a six year window should yield about 30 topics with the potential to produce a breakthrough. Providing strong support to half of these might be accomplished for $300 million a year. That’s roughly half of the recent annual budget of the NIH Common Fund or around 20% of the fiscal year 2025 budget for ARPA-H. After five years, then again at ten, compare to see which group — the one that was actively managed, or the control — produced more breakthroughs, and on what timescale. Although we used biomedicine as an example, the same experiment could just as well be run for physics, materials science, or any other discipline. Any attempt to undertake such an experiment should keep three points top of mind. First, we can predict the topic of future breakthroughs, but the people and vision for how to move the work forward are still important. In practice, this means success requires active program managers with the expertise to develop the science and the authority to do so, including by recruiting investigators. Second, we would be wise to learn from the failures of past attempts to fund transformative research. High among these are funding modestly repackaged work, confusing the genuinely novel with the merely unfamiliar, and relying too much on incumbent investigators. All of these risks can be mitigated by thoroughly and intelligently integrating high quality data into portfolio management. Finally, we need to have patience. Even with strong funding support, producing a breakthrough takes time. If supporting breakthroughs is the best way to nurture the birth of new fields, we also need to accurately describe and properly manage the other two stages, so that we invest wisely throughout the productive lifetime of ideas and divest once they reach the point of diminishing returns. We would benefit from more study of all of these phases, especially the transition from one to another. More research could answer questions like: When does a breakthrough become an established field? How do the availability of funding, the size and characteristics of the available workforce, and the accumulation of evidence that disagrees with prevailing models affect a field’s decline? Exactly how do old ideas give birth to new ones, and can we speed up the process? The more we understand about the dynamics of scientific progress, the better we can maximize the odds that our curiosity leads to results. I’d call that finding a way to make our own luck.
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