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Inside look: Bonaire Park, Summerville’s first-of-its-kind entertainment development

DOWNTOWN SUMMERVILLE, S.C. (WCBD) – Construction is underway on a major new venue in Summerville that local leaders say could transform the town’s entertainment and business landscape. The pr…

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Sep 9 • 4:59 PM EDT • Entertainment • counton2.com
Apple Reveals iPhone 18 Pro and iPhone 18 Pro Max Battery Capacities

Apple has confirmed the battery capacities for the iPhone 18 Pro and iPhone 18 Pro Max models that the company announced earlier today. Apple is required to publish energy labels on its iPhone product pages in the EU, and they reveal the official mAh battery capacities for the devices. Here are the battery capacities for the iPhone 18 Pro and iPhone 18 Pro Max models that still have a SIM card tray, according to Apple: iPhone 18 Pro: 4,056 mAh (+1.7% vs.

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Sep 9 • 4:56 PM EDT • Technology • macrumors.com
Read the Apple document explaining how new listening features still protect your privacy

Will you be using Audio Intelligence?

theverge.com logo
Sep 9 • 4:44 PM EDT • Technology • theverge.com
Zay Flowers on His Health, Declan Doyle's Offense

WR Zay Flowers shares a positive health update despite being limited in Wednesday's practice, discusses his feelings about the season, and more.

baltimoreravens.com logo
Sep 9 • 4:37 PM EDT • Health • baltimoreravens.com
If Meta Glasses Freak You Out, Wait Until You Hear About the New Apple Watch Features

Live Rewind and Siri Recap just killed the dreams of always on AI wearables.

gizmodo.com logo
Sep 9 • 4:30 PM EDT • Technology • gizmodo.com
HHS recognizes Recovery Month, celebrates strength and pathways to recovery | Health and Human Services North Dakota

September is National Recovery Month, as proclaimed by Gov. Kelly Armstrong. The month celebrates people in recovery, the families and communities who support them and the possibility of recovery from mental health and substance use challenges. North Dakota Health and Human Services (HHS) reminds North Dakotans that recovery looks different for everyone, and support is available at every stage of the journey. Read the National Recovery Month proclamation.

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Sep 9 • 4:22 PM EDT • Health • hhs.nd.gov
See how gerrymandering in 2025 changed Missouri’s congressional map

It was chaos in Missouri politics Tuesday as the fight for what map voters will use during the November 2026 election and beyond continues.

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Sep 9 • 3:51 PM EDT • Politics • kansascity.com
Syracuse City Ballet Bringing 'Dracula' to Rome's Capitol Theatre

Syracuse City Ballet will present "Dracula" at The Capitol Theatre in Rome this fall.

wktv.com logo
Sep 9 • 3:27 PM EDT • Entertainment • wktv.com
Syracuse City Ballet Brings 'Dracula' to Rome's Capitol Theatre

Syracuse City Ballet will present "Dracula" at The Capitol Theatre in Rome this fall.

wktv.com logo
Sep 9 • 3:27 PM EDT • Entertainment • wktv.com
Mental Health Board faces forks in the road - Illinois Times, the capital city's weekly source of news, politics, arts, entertainment, culture

Some community members, including the former Massey Commission’s managing director, say the inaugural Sangamon County Mental Health Board has to better address the communities it is attempting to support if the board wants to be successful. Since the Mental Health Board began meeting monthly at the end of May, some of the specific asks have […]

illinoistimes.com logo
Sep 9 • 3:05 PM EDT • Health • illinoistimes.com
Maricopa entertainment center gets a name — MADCAPS

MADCAPS unveils name and first renderings of new entertainment and dining destination at Copper Sky Regional Park.

azbigmedia.com logo
Sep 9 • 2:50 PM EDT • Entertainment • azbigmedia.com
Sacramento drive-in hosts free movie night with kid-friendly options. What to know

Discounts on nachos, bounce houses and other activities will accompany six free movies at the West Wind theater’s movie night.

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Sep 9 • 2:45 PM EDT • Entertainment • sacbee.com
Kinsman Road Appearance Deters New Businesses

Newbury Township officials debated how to address the multitude of landscaping businesses along state Route 87 during the Sept. 2 trustees meeting. Newbury Township Trustees agreed they do not plan to force out the more than a dozen landscaping businesses already established along the corridor. However, they said they would like to see some improve

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Sep 9 • 2:38 PM EDT • Business • geaugamapleleaf.com
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Netflix orders new series based on Larry McMurtry’s ‘Lonesome Dove’

The book originally published in 1985.

star-telegram.com logo
Sep 9 • 2:23 PM EDT • Entertainment • star-telegram.com
Apple unveils Watch Series 12 and Watch Ultra 4 with an AI upgrade that can recap your day

Most notably, Apple is taking aim at the growing wave of AI wearables with new "Audio Intelligence" features that let you rewind moments and remember details from daily conversations.

techcrunch.com logo
Sep 9 • 2:08 PM EDT • Technology • techcrunch.com
Apple Watch Series 12 and Apple Watch Ultra 4: Price, Specs, Release Date

Apple’s latest smartwatches—the Apple Watch Series 12 and Ultra 4, get a faster chip, expanded health tracking, and new capabilities made possible by a newly enhanced Siri.

wired.com logo
Sep 9 • 1:43 PM EDT • Technology • wired.com
Peapack Private Expands Specialty Lending Capabilities with Launch of Yacht Financing Business

Jim Velez Jim Velez, Senior Managing Director and President of Yacht Financing at Peapack Private BEDMINSTER, N.J., Sept. 09, 2026 (GLOBE NEWSWIRE) -- Peapack-Gladstone Financial Corporation (NASDAQ Global Select Market: PGC) and Peapack Private announced today its entrance into the yacht financing business, further expanding the Bank’s suite of customized lending solutions for high-net-worth individuals, families and their advisors. As part of the launch, Peapack Private has hired industry vete

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Sep 9 • 1:01 PM EDT • Business • finance.yahoo.com
Guardians Minor League Recap: Huff Hits Twentieth

Minor League Recaps for 9/1/2026’s games

sports.yahoo.com logo
Sep 9 • 12:41 PM EDT • Sports • sports.yahoo.com
Is it healthy for a child to play one sport all year? There’s a warning

Parents should take note of the medical concerns.

miamiherald.com logo
Sep 9 • 12:38 PM EDT • Health • miamiherald.com
HSBC Premier checking gets an overhaul: Up to $3,000 bonus and enhanced travel, health, and wealth benefits

The HSBC Premier checking has been under the knife, receiving some major updates to its catalog of benefits—making it more compelling than ever.

fortune.com logo
Sep 9 • 11:17 AM EDT • Health • fortune.com
Vrancken has captured imagination of Hearts fans

There was a sense of inevitability about Hearts' late winner against Dundee on Sunday. Much of the credit for Hearts' recent form must go to Wouter Vrancken. The Belgian's style of play has captured the imagination of the Hearts support and, just as importantly, the players have fully embraced his football philosophy.

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Sep 9 • 10:44 AM EDT • Sports • sports.yahoo.com
Ascension economic development pipeline holds $22B in potential investment

The Ascension Parish Economic Development Corporation has recorded $347 million in announced capital investment and 46 new jobs so far this year, according to its president and CEO, Kate MacArthur. … Already an INSIDER? Sign in. Already an INSIDER? Sign in

businessreport.com logo
Sep 9 • 10:34 AM EDT • Business • businessreport.com
Buffalo Museum of Science Unveils $3 Million Science Stadium Permanent Exhibit in Partnership with the Bills, Sabres, and Bandits

Transformative, interactive exhibit merges Western New York’s deep passion for sports with STEM learning; Ribbon-cutting ceremony set for September 24 before September 26 public opening.

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Sep 9 • 9:59 AM EDT • Science • buffalobills.com
Buffalo Museum of Science Unveils $3 Million Science Stadium Permanent Exhibit in Partnership with the Bills, Sabres, and Bandits

Transformative, interactive exhibit merges Western New York’s deep passion for sports with STEM learning; Ribbon-cutting ceremony set for September 24 before September 26 public opening.

buffalobills.com logo
Sep 9 • 9:59 AM EDT • Sports • buffalobills.com
Luma locks down 15-year, $410M fund for life science investments

Luma Group today announced the final close of its inaugural life sciences venture capital fund, totaling $410 million. The New York-based investment firm has had a grip on life sciences since its founding in 2023. The funds unveiled today, dubbed LumaBio Fund I, include investments that have already been made into more than 10 biotechs. They include the likes of eye disease-focused Character Biosciences, rebranded Belgian biotech Coultreon Biopharma and cellular rejuvenation company Altos Labs. The fund saw early success when one of the companies it co-founded, called Vaccine Company, was picked up by Eli Lilly earlier this year for up to $1.55 billion. The acquisition of the in vivo nanoparticle technology-focused biotech formed part of a trio of vaccine buys for the Big Pharma, which has itself been on a prolonged spending spree in 2026. Luma's fund is structured as a 15-year investment with plans to support groundbreaking science and support companies through key milestones from discovery to commercialization, Luma explained in the release. "We founded Luma Group on the belief that extraordinary science, supported by patient, long-term capital, has the power to improve millions of lives," Joshua Fink, founder and managing member of Luma Group, said in the release. "This fund represents more than capital—it is a commitment to partnering with extraordinary innovators as they translate visionary science into life-changing medicines."

fiercebiotech.com logo
Sep 9 • 9:43 AM EDT • Science • fiercebiotech.com
NASCO and Doxim Partner to Modernize Health Plan Administration and Improve Communications

NASCO, a leading provider of healthcare technology solutions, today announced a strategic partnership with Doxim®, a leader in customer communications management (CCM) and engagement technology for highly regulated markets. The collaboration brings together NASCO's deep health plan administration expertise with Doxim's omnichannel communications capabilities to help health plans modernize operations and deliver more seamless, personalized experiences for all healthcare stakeholders.

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Sep 9 • 9:30 AM EDT • Health • finance.yahoo.com
In a forest where Jews fought the Nazis, a German military base and Lithuanian politics encroach on memory

Under German occupation, some 400 Jews escaped the Vilnius ghetto to Lithuania’s Rūdninkai Forest, created forts and organized attacks against the Nazis. Now, construction of a new German military base in the area is throwing into question …

sun-sentinel.com logo
Sep 9 • 9:20 AM EDT • Politics • sun-sentinel.com
Optimal Blue announces initial speaker lineup for 2027 Summit

IMAGE CAPTION: Optimal Blue announces initial speaker lineup for 2027 Summit | Optimal Blue today announced its initial speaker lineup for its 2027 Optimal Blue Summit, including Analyst, ESPN Monday

caledonianrecord.com logo
Sep 9 • 9:08 AM EDT • Entertainment • caledonianrecord.com
Sidney Crosby sparks controversy with surprising take on Mike Babcock

The Penguins captain's surprising assessment comes as Edmonton faces fierce backlash over its decision to hire the veteran coach.

sports.yahoo.com logo
Sep 9 • 9:02 AM EDT • Sports • sports.yahoo.com
Scientists Recreated Chirps of Jurassic Insects, Simulating a 165 Million-yo Soundscape (Listen)

It wasn't just the roars of the dinosaurs that made up the soundscape of the animal world during the Jurassic period.

goodnewsnetwork.org logo
Sep 9 • 9:00 AM EDT • Science • goodnewsnetwork.org
The Cost of Cutting American Science: How Federal Cuts Diminish Public Health Capacity

Among the federal government’s many responsibilities is the work it does to protect public health. Federal agencies monitor our food supply to ensure safety, conduct research to better understand emerging health threats, provide funding for public health programs in communities and work to detect and respond to disease outbreaks. Americans rely on these efforts every day—in a 2024 online survey, 74% of respondents said that “if the federal government issued safety guidance about food you eat regularly,” they would follow it. Changes to Federal Public Health Capacity The Trump administration’s efforts to reshape the federal government have resulted in significant impacts on our nation’s public health capacity over the past 20 months, affecting the response to health concerns such as measles, Ebola and cyclosporiasis. Agencies with core public health, food safety and disease prevention responsibilities experienced large workforce decreases during the first year of the administration. At the Centers for Disease Control and Prevention, for instance, the workforce in February 2026 was 26.7% smaller than in September 2024 before the start of the Trump administration. The Food and Drug Administration saw a similarly steep decline of 21.6%. Agencies such as the National Institutes of Health, Substance Abuse and Mental Health Services Administration and Food Safety and Inspection Service also experienced large workforce decreases. (function(){function e(){window.addEventListener(`message`,function(e){if(e.data[`datawrapper-height`]!==void 0){var t=document.querySelectorAll(`iframe`);for(var n in e.data[`datawrapper-height`])for(var r=0,i;i=t[r];r++)if(i.contentWindow===e.source){var a=e.data[`datawrapper-height`][n]+`px`;i.style.height=a}}})}e()})(); Changes can also be seen in crucial public health occupations. The number of federal food inspectors, for example, decreased by more than half between September 2024 and February 2026, going from 1,035 to 473. This is the lowest number of food inspectors employed by the federal government since at least 2005. By February 2026, there were also 33.3% fewer federal public health program specialists, whose work includes advising federal funding recipients on public health activities and analyzing the effectiveness of public health programs. Government’s capacity is diminished as employees with specialized knowledge and experience in protecting the public and responding to health risks depart, leaving agencies less prepared to carry out their public health missions. There also have been vacancies in critical high-level leadership positions at public health agencies, most notably at the CDC, which had a permanent Senate-confirmed director for less than a month between January 2025 and early August 2026. Although the CDC has previously been led by acting directors at the start of an administration, the nearly yearlong gap since the departure of the administration’s first permanent director in August 2025 is without precedent. As of August 2026, the FDA is also currently without a Senate-confirmed commissioner following the previous commissioner’s resignation in May 2026. Additionally, public health agencies are experiencing increased politicization of their leadership ranks. In agencies such as the CDC and Food Safety and Inspection Service, the number of individuals in the Senior Executive Service—the most senior career leaders in government—has declined significantly, while at the same time the number of political appointees has reached record levels. (function(){function e(){window.addEventListener(`message`,function(e){if(e.data[`datawrapper-height`]!==void 0){var t=document.querySelectorAll(`iframe`);for(var n in e.data[`datawrapper-height`])for(var r=0,i;i=t[r];r++)if(i.contentWindow===e.source){var a=e.data[`datawrapper-height`][n]+`px`;i.style.height=a}}})}e()})(); (function(){function e(){window.addEventListener(`message`,function(e){if(e.data[`datawrapper-height`]!==void 0){var t=document.querySelectorAll(`iframe`);for(var n in e.data[`datawrapper-height`])for(var r=0,i;i=t[r];r++)if(i.contentWindow===e.source){var a=e.data[`datawrapper-height`][n]+`px`;i.style.height=a}}})}e()})(); At the CDC, for example, the number of career SES decreased 42.9% between December 2024 and February 2026, while the number of non-Senate confirmed political appointees at the agency was six times larger than the agency’s historical average from 2009 and 2024. Knowledgeable career leaders are integral to the ability of public health agencies to carry out their work with scientific integrity and professional judgment, and rapid leadership turnover and increased politicization threaten agencies’ ability to make evidence-based decisions to protect our health. The upheaval and politicization in public health agencies have also negatively affected employee engagement. Strong employee engagement is crucial to the ability of agencies to carry out their mission and successfully provide essential services to the public. In the 2025 Public Service Viewpoint Survey conducted by the Partnership for Public Service, the Department of Health and Human Services—which encompasses major public health agencies such as the CDC and FDA—had an employee engagement and satisfaction score of 20.4 out of 100, one of the lowest among large agencies. Only 2.8% of HHS employees indicated trust in their political leaders and only 8.7% reported confidence that they could report a suspected violation of law or regulation without retaliation. Employees at HHS also reported that the agency’s ability to provide services to the public had suffered. Nearly half of employees at HHS, 47.5%, said their work unit was worse at delivering quality services compared to its performance in 2024. In addition, 57.8% said their work unit was performing worse at fulfilling stakeholder needs. In addition to the work done within federal agencies, the federal government also distributes significant funding for public health and disease prevention work to state and local governments, nonprofits and small businesses—funding which has been significantly disrupted. At the CDC, for example, there was a 71.9% decrease in the amount of project grant funding issued in fiscal year 2025 compared to fiscal year 2024. The FDA also issued far less funding in fiscal year 2025—a 21.3% decrease from its fiscal year 2024 funding. Changes in federal funding include the ending of grants to community organizations that worked on HIV prevention and the cancellation of funding for research into improvements to patient safety and healthcare quality. These changes go beyond federal agencies to impact the broader public health ecosystem, including the state and local health departments responsible for much of the on-the-ground public health work in their communities. About 80% of the CDC’s domestic funding is directed towards state and local partners—meaning that cuts to CDC funding can ultimately result in cuts to state and local public health capacity. Federal agencies also provide expertise and assistance to state and local health agencies as they deal with particular health challenges, but workforce cuts have resulted in fewer federal employees available to help. The Impact of Changes to Public Health Capacity These changes to federal public health capacity are not abstract concerns. Disrupted programs, reduced funding and lost expertise at public health agencies across all levels of government threaten the public’s physical well-being and safety. In some cases, this has already led to harm. The most immediate impacts of federal cuts were seen in interruptions to ongoing public health programs and crisis responses. In one instance, when CDC grants were canceled during the 2025 Texas measles outbreak—the most severe measles outbreak in 25 years—public health officials in Lubbock, Texas were forced to pause parts of their measles response work supported by the frozen funding. Lubbock’s director of public health further said that a lack of available CDC experts to reach out to for advice “definitely” impacted the department’s response to the measles crisis. Cuts to federal funding also forced Dallas County Health and Human Services to cut staff and cancel 50 community vaccination clinics during the outbreak. Public health work outside of major outbreak responses was also disrupted. For example, in April 2025, the Milwaukee Public Health Department was unexpectedly unable to reach experts on lead poisoning due to firings at the CDC when responding to concerns about lead contamination in Milwaukee public schools. Due to federal workforce cuts, several programs at the CDC, including Alzheimer’s and epilepsy programs, have also become trapped in limbo—existing on paper, but without the staff necessary to operate. More recent crises reveal how federal cuts have weakened the public health infrastructure needed to prevent and respond to dangerous new outbreaks. Internationally, cuts at the U.S. Agency for International Development eliminated funding for disease testing and contact tracing abroad, which delayed detection of and responses to the 2026 Ebola outbreak in the Democratic Republic of Congo. While international outbreaks may seem far removed, the unchecked spread of disease in any country can quickly pose a danger to economic well-being, security and health around the world. Within the United States, public health cuts inhibited responses to the summer 2026 outbreak of the food-borne parasite cyclospora. At the federal level, cuts to funding for lab equipment and for CDC staff with expertise in parasitic infections—including 9 out of 11 staff members at the lab responsible for identifying parasitic outbreaks in 2025— contributed to the largest reporting delay in outbreak cases at the CDC in 15 years. Conflicting communications from the FDA about the source of the outbreak, which followed cuts to the agency’s communications department, additionally led to confusion among the public about how to best avoid infection. At the same time, cuts to HHS funding and support for local and state public health slowed some health departments’ responses to the crisis. The exact costs of these delays, constraints and confusion in public health responses are difficult to estimate. However, their message is clear: federal cuts have already made containing threats to public health even more of a challenge. Conclusion Protecting public health—from food safety to disease prevention—is one of the federal government’s most important missions. Dramatic and haphazard cuts to federal agencies and funding have already disrupted the public health system, impacting the response to challenges such as measles, lead poisoning and cyclosporiasis. The U.S. public health system needed improvement before these disruptions. Since 2022, federal leadership and coordination in response to public health outbreaks has been on the Government Accountability Office’s High-Risk List of areas in need of attention to improve government effectiveness and efficiency. Recent cuts only compound these concerns. The chaotic dismantling of government and resulting disruptions to crucial functions like public health and disease prevention highlight the need for meaningful reform and concrete policy proposals to reimagine how government can better serve the public and be more effective, responsive and accountable. To learn more about the impact of federal cuts to public health and science more broadly, visit The Cost of Cutting American Science. Learn more For more information on the Partnership for Public Service’s government reform initiative, visit Government for a New Era. View here In line with The Cost of Cutting American Science, federal workforce data in this brief is as of February 2026

ourpublicservice.org logo
Sep 9 • 9:00 AM EDT • Science • ourpublicservice.org
The Cost of Cutting American Science: How Federal Cuts Diminish Public Health Capacity

Among the federal government’s many responsibilities is the work it does to protect public health. Federal agencies monitor our food supply to ensure safety, conduct research to better understand emerging health threats, provide funding for public health programs in communities and work to detect and respond to disease outbreaks. Americans rely on these efforts every day—in a 2024 online survey, 74% of respondents said that “if the federal government issued safety guidance about food you eat regularly,” they would follow it. Changes to Federal Public Health Capacity The Trump administration’s efforts to reshape the federal government have resulted in significant impacts on our nation’s public health capacity over the past 20 months, affecting the response to health concerns such as measles, Ebola and cyclosporiasis. Agencies with core public health, food safety and disease prevention responsibilities experienced large workforce decreases during the first year of the administration. At the Centers for Disease Control and Prevention, for instance, the workforce in February 2026 was 26.7% smaller than in September 2024 before the start of the Trump administration. The Food and Drug Administration saw a similarly steep decline of 21.6%. Agencies such as the National Institutes of Health, Substance Abuse and Mental Health Services Administration and Food Safety and Inspection Service also experienced large workforce decreases. (function(){function e(){window.addEventListener(`message`,function(e){if(e.data[`datawrapper-height`]!==void 0){var t=document.querySelectorAll(`iframe`);for(var n in e.data[`datawrapper-height`])for(var r=0,i;i=t[r];r++)if(i.contentWindow===e.source){var a=e.data[`datawrapper-height`][n]+`px`;i.style.height=a}}})}e()})(); Changes can also be seen in crucial public health occupations. The number of federal food inspectors, for example, decreased by more than half between September 2024 and February 2026, going from 1,035 to 473. This is the lowest number of food inspectors employed by the federal government since at least 2005. By February 2026, there were also 33.3% fewer federal public health program specialists, whose work includes advising federal funding recipients on public health activities and analyzing the effectiveness of public health programs. Government’s capacity is diminished as employees with specialized knowledge and experience in protecting the public and responding to health risks depart, leaving agencies less prepared to carry out their public health missions. There also have been vacancies in critical high-level leadership positions at public health agencies, most notably at the CDC, which had a permanent Senate-confirmed director for less than a month between January 2025 and early August 2026. Although the CDC has previously been led by acting directors at the start of an administration, the nearly yearlong gap since the departure of the administration’s first permanent director in August 2025 is without precedent. As of August 2026, the FDA is also currently without a Senate-confirmed commissioner following the previous commissioner’s resignation in May 2026. Additionally, public health agencies are experiencing increased politicization of their leadership ranks. In agencies such as the CDC and Food Safety and Inspection Service, the number of individuals in the Senior Executive Service—the most senior career leaders in government—has declined significantly, while at the same time the number of political appointees has reached record levels. (function(){function e(){window.addEventListener(`message`,function(e){if(e.data[`datawrapper-height`]!==void 0){var t=document.querySelectorAll(`iframe`);for(var n in e.data[`datawrapper-height`])for(var r=0,i;i=t[r];r++)if(i.contentWindow===e.source){var a=e.data[`datawrapper-height`][n]+`px`;i.style.height=a}}})}e()})(); (function(){function e(){window.addEventListener(`message`,function(e){if(e.data[`datawrapper-height`]!==void 0){var t=document.querySelectorAll(`iframe`);for(var n in e.data[`datawrapper-height`])for(var r=0,i;i=t[r];r++)if(i.contentWindow===e.source){var a=e.data[`datawrapper-height`][n]+`px`;i.style.height=a}}})}e()})(); At the CDC, for example, the number of career SES decreased 42.9% between December 2024 and February 2026, while the number of non-Senate confirmed political appointees at the agency was six times larger than the agency’s historical average from 2009 and 2024. Knowledgeable career leaders are integral to the ability of public health agencies to carry out their work with scientific integrity and professional judgment, and rapid leadership turnover and increased politicization threaten agencies’ ability to make evidence-based decisions to protect our health. The upheaval and politicization in public health agencies have also negatively affected employee engagement. Strong employee engagement is crucial to the ability of agencies to carry out their mission and successfully provide essential services to the public. In the 2025 Public Service Viewpoint Survey conducted by the Partnership for Public Service, the Department of Health and Human Services—which encompasses major public health agencies such as the CDC and FDA—had an employee engagement and satisfaction score of 20.4 out of 100, one of the lowest among large agencies. Only 2.8% of HHS employees indicated trust in their political leaders and only 8.7% reported confidence that they could report a suspected violation of law or regulation without retaliation. Employees at HHS also reported that the agency’s ability to provide services to the public had suffered. Nearly half of employees at HHS, 47.5%, said their work unit was worse at delivering quality services compared to its performance in 2024. In addition, 57.8% said their work unit was performing worse at fulfilling stakeholder needs. In addition to the work done within federal agencies, the federal government also distributes significant funding for public health and disease prevention work to state and local governments, nonprofits and small businesses—funding which has been significantly disrupted. At the CDC, for example, there was a 71.9% decrease in the amount of project grant funding issued in fiscal year 2025 compared to fiscal year 2024. The FDA also issued far less funding in fiscal year 2025—a 21.3% decrease from its fiscal year 2024 funding. Changes in federal funding include the ending of grants to community organizations that worked on HIV prevention and the cancellation of funding for research into improvements to patient safety and healthcare quality. These changes go beyond federal agencies to impact the broader public health ecosystem, including the state and local health departments responsible for much of the on-the-ground public health work in their communities. About 80% of the CDC’s domestic funding is directed towards state and local partners—meaning that cuts to CDC funding can ultimately result in cuts to state and local public health capacity. Federal agencies also provide expertise and assistance to state and local health agencies as they deal with particular health challenges, but workforce cuts have resulted in fewer federal employees available to help. The Impact of Changes to Public Health Capacity These changes to federal public health capacity are not abstract concerns. Disrupted programs, reduced funding and lost expertise at public health agencies across all levels of government threaten the public’s physical well-being and safety. In some cases, this has already led to harm. The most immediate impacts of federal cuts were seen in interruptions to ongoing public health programs and crisis responses. In one instance, when CDC grants were canceled during the 2025 Texas measles outbreak—the most severe measles outbreak in 25 years—public health officials in Lubbock, Texas were forced to pause parts of their measles response work supported by the frozen funding. Lubbock’s director of public health further said that a lack of available CDC experts to reach out to for advice “definitely” impacted the department’s response to the measles crisis. Cuts to federal funding also forced Dallas County Health and Human Services to cut staff and cancel 50 community vaccination clinics during the outbreak. Public health work outside of major outbreak responses was also disrupted. For example, in April 2025, the Milwaukee Public Health Department was unexpectedly unable to reach experts on lead poisoning due to firings at the CDC when responding to concerns about lead contamination in Milwaukee public schools. Due to federal workforce cuts, several programs at the CDC, including Alzheimer’s and epilepsy programs, have also become trapped in limbo—existing on paper, but without the staff necessary to operate. More recent crises reveal how federal cuts have weakened the public health infrastructure needed to prevent and respond to dangerous new outbreaks. Internationally, cuts at the U.S. Agency for International Development eliminated funding for disease testing and contact tracing abroad, which delayed detection of and responses to the 2026 Ebola outbreak in the Democratic Republic of Congo. While international outbreaks may seem far removed, the unchecked spread of disease in any country can quickly pose a danger to economic well-being, security and health around the world. Within the United States, public health cuts inhibited responses to the summer 2026 outbreak of the food-borne parasite cyclospora. At the federal level, cuts to funding for lab equipment and for CDC staff with expertise in parasitic infections—including 9 out of 11 staff members at the lab responsible for identifying parasitic outbreaks in 2025— contributed to the largest reporting delay in outbreak cases at the CDC in 15 years. Conflicting communications from the FDA about the source of the outbreak, which followed cuts to the agency’s communications department, additionally led to confusion among the public about how to best avoid infection. At the same time, cuts to HHS funding and support for local and state public health slowed some health departments’ responses to the crisis. The exact costs of these delays, constraints and confusion in public health responses are difficult to estimate. However, their message is clear: federal cuts have already made containing threats to public health even more of a challenge. Conclusion Protecting public health—from food safety to disease prevention—is one of the federal government’s most important missions. Dramatic and haphazard cuts to federal agencies and funding have already disrupted the public health system, impacting the response to challenges such as measles, lead poisoning and cyclosporiasis. The U.S. public health system needed improvement before these disruptions. Since 2022, federal leadership and coordination in response to public health outbreaks has been on the Government Accountability Office’s High-Risk List of areas in need of attention to improve government effectiveness and efficiency. Recent cuts only compound these concerns. The chaotic dismantling of government and resulting disruptions to crucial functions like public health and disease prevention highlight the need for meaningful reform and concrete policy proposals to reimagine how government can better serve the public and be more effective, responsive and accountable. To learn more about the impact of federal cuts to public health and science more broadly, visit The Cost of Cutting American Science. Learn more For more information on the Partnership for Public Service’s government reform initiative, visit Government for a New Era. View here In line with The Cost of Cutting American Science, federal workforce data in this brief is as of February 2026

ourpublicservice.org logo
Sep 9 • 9:00 AM EDT • Health • ourpublicservice.org
Two Whatcom County businesses opened last month; two others closed permanently

Check out Bellingham’s latest business news. We’re keeping track of openings and closings.

bellinghamherald.com logo
Sep 9 • 8:35 AM EDT • Business • bellinghamherald.com
GameSquare Enters Definitive Contribution Agreement to Acquire Sports, Music and Entertainment IP Assets from FanEngine

Highly profitable transaction expected to be immediately accretive to earnings and support multiple recurring revenue opportunitiesFanEngine's assets add well-known global IP assets Peaky Blinders, Simon's Cat, The Two Robbies and Friends, 4Cast Media Platform featuring Former England Captain Ben S…

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Sep 9 • 8:00 AM EDT • Entertainment • tradingview.com
Capitol agenda: Will Schumer go long for college sports? - Live Updates

Schumer must decide if he wants to steer his members toward helping Republicans reach the 60-vote threshold on what could be the sweepiest bill the chamber passes before the midterms.

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Sep 9 • 8:00 AM EDT • Sports • politico.com
Singapore PM salary set to rise to $2.85M under political pay overhaul

Singapore updated its executive compensation benchmarks, setting its prime minister pay target at $2.85 million while capping initial actual raises at 9%.

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Sep 9 • 7:52 AM EDT • Politics • foxbusiness.com
Scientists in Switzerland made a sponge from cheesemaking waste that captures gold from discarded electronics — after dissolving metal parts from 20 old computer motherboards, they recovered enough to melt into a 22-carat gold nugget

A Swiss lab transformed dairy waste into a gold-recovery tool, extracting precious metal from e-waste that most recyclers leave behind.

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Sep 9 • 7:15 AM EDT • Science • scienceblog.com
New Anita Earls campaign ad + protest outside NC Supreme Court

Read our Under the Dome newsletter to stay up to date on North Carolina politics, delivered to your inbox.

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Sep 9 • 7:00 AM EDT • Politics • newsobserver.com
Marquinhos ‘hopes’ another PSG player wins the Ballon d’Or

Paris Saint-Germain captain Marquinhos (32) has said that he hopes that a PSG player wins this year’s edition of the Ballon d’Or. The Brazilian is one of nine Parisiens nominated for the award.The...

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Sep 9 • 6:35 AM EDT • Sports • sports.yahoo.com
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Donald Trump Jr.'s venture capital firm rejects House Democrat's accusations of "insider political influence"

Rep. Jamie Raskin launched an investigation last month into the president's son's investment firm and its "almost clairvoyant" business moves.

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Sep 9 • 6:05 AM EDT • Politics • cbsnews.com
High-Signal Publisher
5 fun events happening in Madison this week, Sept. 10-16 🎤🧶🍺

This week around Madison, see SNL's Kam Patterson, check out the Great Wisconsin Quilt Show, celebrate Oktoberfest at Working Draft and more.

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Sep 9 • 6:05 AM EDT • Entertainment • captimes.com
Giants Now: CBS Sports' Preseason All-Rookie Team

The news of the day for Giants fans on Wednesday, September 9, 2026.

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Sep 9 • 6:00 AM EDT • Sports • giants.com
How a fight to save Wisconsin's Black babies keeps hitting a dead end

Black Caucus members Shelia Stubbs, LaTonya Johnson, Margaret Arney, Sequanna Taylor and Dora Drake are on a mission to end the infant mortality crisis.

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Sep 9 • 6:00 AM EDT • Health • captimes.com
Editorial | Black infant mortality rate is a public health crisis

Editorial: Despite a mortality rate three times higher than white infants, Republicans like Tom Tiffany have opposed efforts to address race-based inequities in healthcare.

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Sep 9 • 6:00 AM EDT • Health • captimes.com
The lives of Idaho wilderness guides seem ideal but often hide pain

It’s an emotional let-down when the river runs end for the season and the wonderful people she met along the way are gone | Opinion

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Sep 9 • 6:00 AM EDT • Health • idahostatesman.com
Wisconsin volleyball doesn't panic after tough start to season

Coach Kelly Sheffield contrasts his Badgers' response to adversity with a scene from "Animal House."

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Sep 9 • 6:00 AM EDT • Sports • captimes.com
Hiltzik: Resisting Trump turns out to be a winning business strategy

A study finds that businesses that resisted Trump's anti-diversity pressure paid no price. Are the law firms and universities that capitulated listening?

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Sep 9 • 6:00 AM EDT • Business • latimes.com
Akron Art Museum unveils $12.5M renovation aimed at doubling attendance

Backed by a capital campaign and $2M in state funds, the Akron Art Museum's $12M expansion opens Sept. 23 with new galleries, a black box and expanded education space.

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Sep 9 • 5:45 AM EDT • Entertainment • crainscleveland.com
Company that pledged 200 jobs in Charlotte leaves town for SC, loses NC incentives

The company, known for brands like Dirt Devil, announced a $5 million investment in 2015.

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Sep 9 • 5:27 AM EDT • Business • charlotteobserver.com
Ralph Alvarado kept outside jobs while working as Tennessee health commissioner

Reports show that Alvarado, now a GOP congressional candidate, worked for Kentucky nursing homes and other facilities while in Tennessee.

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Sep 9 • 5:00 AM EDT • Health • kentucky.com
Did New Film Unit Just Shift AMC Stock’s Investment Narrative?

AMC Entertainment Holdings recently launched Leawood Films, a film distribution unit based in Los Angeles and Leawood, Kansas, aiming to bring more small and mid-sized movies into theatres worldwide while relying on fully financed projects to limit production risk. The new distributor uses AMC’s excess screen capacity and past concert-film marketing experience to secure theatrical placement for filmmakers who might otherwise struggle to find backing, while leaving most downstream revenue and...

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Sep 9 • 4:31 AM EDT • Entertainment • simplywall.st
Today’s Papers – Big Inter gifts, Juventus in trouble

La Gazzetta dello SportJuve, you need to get yourself blessed.Locatelli returns in 2027; stop for BogaAfter Yildiz and Thuram, the captain underwent surgery too (could be out for six months)Inter’s ...

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Sep 9 • 3:55 AM EDT • Sports • sports.yahoo.com
The new Apple Watch will use microphone and other sensors to generate AI recaps of your day

Apple will announce the new Apple Watch lineup later today, and Mark Gurman at Bloomberg has the early scoop. He...

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Sep 9 • 3:52 AM EDT • Technology • 9to5mac.com
Seagulls must learn from slow start

It's been a busy start to the 2026-27 campaign for Brighton and Fabian Hurzeler must now begin to prepare for a packed schedule of domestic and European football. Although the Seagulls will wait until October for their Conference League league phase to start, Hurzeler's side has endured a flurry of mixed results in their opening five games of the season. After a bruising 4-3 loss at Stamford Bridge to transfer-foes Chelsea, Brighton were lucky to escape with a 1-1 draw at home to Leeds.

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Sep 9 • 2:55 AM EDT • Sports • sports.yahoo.com
From moving people to managing them

Transportation policy used to have a fairly uncomplicated purpose: move people safely, efficiently and reliably. Build roads where people drive. Maintain bridges before they fail. Add capacity where growth overwhelms the system. Provide transit where it makes sense. Infrastructure was supposed to accommodate human behavior. Colorado increasingly prefers the opposite arrangement. Today, transportation policy is […]

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Sep 9 • 2:45 AM EDT • Politics • coloradopolitics.com
America’s New National Security Science & Technology Strategy

America’s New National Security Science & Technology Strategy Should Test Authority, Not Just Capability The White House is right to make AI, autonomy, resilient PNT, advanced sensing, cyber

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Sep 9 • 1:00 AM EDT • Science • realcleardefense.com
America’s New National Security Science & Technology Strategy

America’s New National Security Science & Technology Strategy Should Test Authority, Not Just Capability

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Sep 9 • 1:00 AM EDT • Science • realcleardefense.com
MidCap Business Credit Closes $10MM Asset-Based Credit Facility for Paper Converter

MidCap Business Credit closed a $10 million asset-based credit facility for a privately held paper converter specializing in custom paper products for

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Sep 9 • 12:58 AM EDT • Business • abfjournal.com
Perea Rejoins FGI Risk as Director of Business Development

FGI Worldwide, a provider of working capital financing and trade credit insurance solutions, readded Rick Perea to FGI Risk as director of business

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Sep 9 • 12:50 AM EDT • Business • abfjournal.com
😐 Neutral (0%)
New York Yankees clinch 34th straight winning season but have much bigger goals

For the New York Yankees, clinching their 34th consecutive winning season was a milepost rather than a milestone. “We're the Yankees, and we're going to win,” captain Aaron Judge said after New York beat the Colorado Rockies 5-3 on Tuesday night for its 82nd victory. New York’s streak is the second-longest in the four major U.S. professional sports leagues behind the Yankees’ record 39 winning seasons in a row from 1926-64.

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Sep 9 • 12:29 AM EDT • Sports • sports.yahoo.com
Prep sports recap for Sept. 8, 2026

PEORIA, Ill. (WMBD/WYZZ) — Now there’s only one undefeated soccer team in the Big 12 Conference. Gavin Stickelmaier and Cal Byrkit scored two goals apiece as Notre Dame beat visiting Champaign Central, 6-0, in the Big 12 opener for both schools on Tuesday. The Irish (4-0) handed the Maroons (2-1-1) their first loss of the […]

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Sep 9 • 12:14 AM EDT • Sports • sports.yahoo.com
Tucker Kraft named team captain for Packers

GREEN BAY, W.I. (KELO) — Timber Lake native and former SDSU Jackrabbit Tucker Kraft was named one of five team captains for the Green Bay Packers ahead of the 2026 season. This is Kraft’s second season as an offensive captain for the Packers. This Sunday against the Minnesota Vikings Kraft is set to make his […]

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Sep 8 • 11:54 PM EDT • Sports • sports.yahoo.com
Edmond hospital employee charged with stealing fentanyl from OU Health

An Edmond hospital employee is accused of stealing fentanyl waste from OU Health, with surveillance video reportedly capturing the incident.

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Sep 8 • 9:00 PM EDT • Health • koco.com
Repairman snares alleged air-conditioner vandal above Houston business

A repairman was able to block the escape route.

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Sep 8 • 8:27 PM EDT • Business • yahoo.com
Tiafoe escapes Michelsen to reach US Open semi-finals

Frances Tiafoe rallied from two sets down -- and 3-0 down in the fifth set -- to edge 22-year-old Alex Michelsen 5-7, 3-6, 7-5, 6-3, 7-6 (10/6) and reach the US Open semi-finals on Tuesday.But in a match of swinging momentum shifts, Tiafoe battled back from 5-3 down in the third set and recovered an early break in the fifth to reach his third US Open semi-final in five years.

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Sep 8 • 8:23 PM EDT • Sports • sports.yahoo.com
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Michigan Fans Split On Bryce Underwood Ahead Of Oklahoma

Michigan fans are split on Bryce Underwood after the Western Michigan escape, with Oklahoma next. #GoBlue

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Sep 8 • 8:00 PM EDT • Sports • sports.yahoo.com
Bills Announce Exciting Josh Allen News Before Season Opener

The Buffalo Bills announced that quarterback Josh Allen is among the six players picked as captains for the 2026 season. The post Bills Announce Exciting Josh Allen News Before Season Opener appeared first on HEAVY.

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Sep 8 • 6:38 PM EDT • Sports • sports.yahoo.com
Activists detained at Oregon State Capitol protesting lithium mine

Activists from Portland, Eugene and southern Oregon were urging Gov. Tina Kotek to step in and stop a controversial lithium mining project.

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Sep 8 • 6:20 PM EDT • Politics • statesmanjournal.com
LG TV shown capable of tracking user activity, even when offline

“It doesn’t cost a lot to store text forever.”...

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Sep 8 • 5:52 PM EDT • Technology • arstechnica.com
Three-time MVP Aaron Judge returns to Yankees

BRONX, N.Y. (WIVT/WBGH) – Sticking with the diamond, let’s move up to the major leagues where the Yankees are set to welcome back the captain tonight. Aaron Judge is making his return in the pinstripes tonight. No. 99 ironically had a 99-day absence after he suffered a broken rib. The three-time AL MVP missed 84 […]

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Sep 8 • 5:47 PM EDT • Sports • sports.yahoo.com
Browns news: Deshaun Watson a team captain for Week 1

The Cleveland Browns and head coach Todd Monken have opted to deploy captains on a week-to-week basis this year, rather than instill season-long captains. The team is young and still trying to figure things out, and Monken believes there are more leaders on the team than just five. Monken will name two offensive, two defensive, and one special […] The post Browns news: Deshaun Watson a team captain for Week 1 appeared first on ClutchPoints.

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Sep 8 • 5:23 PM EDT • Sports • sports.yahoo.com
New Mobile Crisis vehicle expands behavioral health response in Broome County

The expanded program took effect April 1 and includes increased staffing and response capacity for community-based behavioral health crisis services throughout Broome County.

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Sep 8 • 5:21 PM EDT • Health • wbng.com
Driver crashes through Bradenton business on Cortez Road, police say

Bradenton police said the crash happened Sunday afternoon.

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Sep 8 • 4:51 PM EDT • Business • bradenton.com
2026 North Dakota Behavioral Health & Children and Family Services Conference is next week | Health and Human Services North Dakota

Registration is open for the sixth annual North Dakota Health and Human Services (HHS) Behavioral Health & Children and Family Services Conference, scheduled for Sept. 14-17 in Bismarck. The conference will also be available virtually.

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Sep 8 • 4:41 PM EDT • Health • hhs.nd.gov
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North Carolina MCO Alliance Health Taps Cortica to Rein in Autism Spending, Improve Outcomes

Ready to dive into what's shaping autism therapy-payer relations? Be a part of the Autism Investor Summit East this November 9–10. Get your tickets here.

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Sep 8 • 4:03 PM EDT • Health • bhbusiness.com
These Companies Made the Inc. Best in Business List. Here’s What Happened Next

Award winners share how they capitalized on the momentum from their Best in Business recognition.

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Sep 8 • 3:57 PM EDT • Business • inc.com
Mapping the Global Health Landscape: Analysis of Fourteen International Organizations

The global health architecture includes a number of diverse international organizations with different mandates, governance models, financing structures, and operational approaches. This KFF resource looks across a range of variables to provide a descriptive mapping of 14 key global health and related international institutions. It is intended to inform discussions about synergies and coordination, duplication, comparative advantage, shared challenges, and architectural reform.

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Sep 8 • 3:43 PM EDT • Health • kff.org
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Sporting KC Weekly Schedule: Sept. 8-13, 2026

Sporting Kansas City II News: The official source for all SKC II news, photos, videos, highlights, and more.

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Sep 8 • 3:30 PM EDT • Sports • sportingkc.com
Buffalo Bills name 6 captains for 2026 NFL season

Who joins quarterback Josh Allen and linebacker Terrell Bernard as an official captain for the Buffalo Bills in 2026?

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Sep 8 • 3:28 PM EDT • Sports • sports.yahoo.com
Tyler Shough, Cam Jordan among Saints 9 captains for 2026
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Sep 8 • 3:18 PM EDT • Sports • sports.yahoo.com
Study finds social, financial, and healthcare factors shape resilience in adults with sickle cell disease

A new study explores how individual and community health experiences of adults with Sickle Cell Disease (SCD) shape resilience — the capacity to adapt to adversity.

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Sep 8 • 2:55 PM EDT • Health • eurekalert.org
Houston Texans Name Captains for the 2026 Season
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Sep 8 • 1:00 PM EDT • Sports • sports.yahoo.com
Wisconsin workers see higher wages, fewer jobs, increased disparities

The median wage for Wisconsin workers is $26.17 according to a “State of Working Wisconsin” report. Job growth is slowing as racial disparities trend up.

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Sep 8 • 12:20 PM EDT • Business • captimes.com
Months of Pain, Delayed Care: An Asylum Seeker’s Health Crisis in ICE Custody

Mother held at San Diego immigration facility says months of delayed and inadequate medical care have left her with serious kidney infection and worsening pain.

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Sep 8 • 12:03 PM EDT • Health • capitalandmain.com
How UC Davis Strengthens the Forensic Science Workforce

Meet UC Davis students and alumni using a forensic science degree to build careers analyzing DNA evidence and chemicals in crime labs.

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Sep 8 • 12:00 PM EDT • Science • ucdavis.edu
Michigan Football Film Room: Fixing the Run Game

Michigan Football escaped Western Michigan, but serious offensive concerns remain. We break down the Wolverines’ run-game struggles and what must improve in this week’s film study:

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Sep 8 • 12:00 PM EDT • Sports • sports.yahoo.com
Netflix VP of Global Live Sports & Entertainment on WWE: "They’ve been great partners, and we’re thrilled with the results so far" - POST Wrestling | Podcasts, News, Reviews

Gabe Spitzer, a Vice President at Netflix, spoke with Richard Deitsch on the Sports Media podcast regarding their relationship with WWE.

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Sep 8 • 11:59 AM EDT • Entertainment • postwrestling.com
William Shatner reveals truth behind 'Star Trek' Tribbles scene, sliding doors

LOS ANGELES ― While still helming the U.S.S. Enterprise as rugged Captain James T.

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Sep 8 • 11:39 AM EDT • Entertainment • centraloregondaily.com
Foster Swift Welcome Hahn and Serra, Strengthens Business Law and General Counsel Services in Southeast Michigan

Attorney Marcy Hahn Attorney Lisa Serra SOUTHFIELD, Mich., Sept. 08, 2026 (GLOBE NEWSWIRE) -- Foster Swift Collins & Smith, PC is pleased to announce that attorneys Marcy Hahn and Lisa M. Serra have joined the firm's Southfield office, further strengthening its business law, corporate counseling, and general counsel capabilities throughout Southeast Michigan. Marcy and Lisa bring a unique blend of practices including fractional general counsel to business owners along with family law representat

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Sep 8 • 11:38 AM EDT • Business • finance.yahoo.com
On missing Aaron Judge

Welcome back, Captain.

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Sep 8 • 11:30 AM EDT • Sports • sports.yahoo.com
Chrome is now shipping updates every 2 weeks as AI changes the security landscape

Google is speeding up Chrome’s release schedule to ship security patches and new features faster.

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Sep 8 • 11:04 AM EDT • Technology • techcrunch.com
Are Irving, LaVine, Holiday realistic for Heat? And surprising Richards info

The Heat’s challenges in landing one more impactful player. And some notable data on new backup center Nick Richards.

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Sep 8 • 11:01 AM EDT • Sports • miamiherald.com
In 12 years, Triangle man missed only 1 health insurance payment. He lost coverage

A mistake setting up autopay proved costly for this Morrisville family. Here’s what happened — and how you can avoid it.

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Sep 8 • 11:00 AM EDT • Health • newsobserver.com
Louisiana concrete companies join forces to capitalize on construction boom

Two Louisiana concrete suppliers are joining forces with two out-of-state companies to pursue large-scale construction projects as billions of dollars in new industrial and technology investment move … Already an INSIDER? Sign in. Already an INSIDER? Sign in

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Sep 8 • 10:52 AM EDT • Business • businessreport.com
AZ's R&D chief Barr touts internal 'science success story' after IL-33 antibody's stellar showing in COPD

With a detailed data drop that AstraZeneca’s R&D chief described as an internal “science success story,” the British Big Pharma has secured an FDA priority review for what it believes could become a flagship biologic in chronic obstructive pulmonary disease (COPD). In detailed results from the late-stage Oberon and Titania trials—first teased in March and detailed in full at the European Respiratory Society Congress in Barcelona this week—the drugmaker laid out the extent of its IL-33 inhibitor’s potential to reduce moderate and severe exacerbations in a wide range of COPD patients still struggling with those “lung attacks,” as AstraZeneca’s Sharon Barr, Ph.D., called them, despite using standard-care inhaled therapy. In the headline results, a 300 mg dose of tozorakimab given once every four weeks curbed those moderate and severe exacerbations in the studies’ primary population of former smokers by 29% in the Oberon study and 34% in Titania. In the overall population of both current and former smokers, these reductions were 30% and 29%, respectively, versus placebo and inhaled standard of care. The benefits also extended to clinically meaningful exacerbation reductions in all prespecified patient subgroups and specifically turned up promising signals in patients across a range of blood eosinophil counts, with Barr telling Fierce that “it’s the details that make this even more exciting than the high-level results that we’ve already shared.” In fact, during AZ’s tozorakimab poster presentation at the ERS 2026 Congress this past weekend, attendees were so enamored by the data that event organizers had to encourage people to clear the room and look at the other presentations on offer, Barr said in an interview. “I think it really speaks to the fact that there is a lot of buzz around these data because the entire respiratory community has been so desperate for new therapies for these patients,” she explained. The respiratory disease continues to represent a “staggering unmet medical need,” Barr said, highlighting the COPD exacerbations that the Oberon and Titania studies homed in on, which she added carry a greater mortality risk than a heart attack. “When a patient has a severe exacerbation, only about half of them are still alive within three and a half years,” she pointed out. As for tozorakimab specifically, Barr christened the molecule “an AstraZeneca science success story,” harkening several years back to the point at which researchers began to explore IL-33 as a driver of respiratory disease, and COPD in particular. At the same time, “there was still so much that wasn’t understood,” she admitted, highlighting the insight that IL-33 signals through both ST2 and EGFR through the RAGE pathway, a discovery Barr attributed to AstraZeneca's own scientists. Understanding the need to tackle both pathways in COPD—and aware of competitor candidates in the hopper, including one that bound ST2—the company ultimately had to make some “courageous decisions,” Barr said. These included taking a prior COPD molecule offline and going back to the drawing board to reinvent its potential IL-33 label “to make sure that we had a molecule that could block signaling through both arms of the pathway, through both the reduced form and the oxidized form, knowing that we wouldn’t be first, but striving to be best.” “When we put [tozorakimab] into the clinic, we firmly believed that we had a differentiated molecule, and we saw the other molecules blocking just ST2 or partially blocking IL-33, unable to deliver two positive pivotal studies in COPD,” Barr explained. “We kept marching forward because we believed our molecule was differentiated, and now I think we have the clinical validation that supports that.” Ultimately, AstraZeneca finds itself on much better footing these days when it comes to potential biologic rivals to tozorakimab in COPD. Sanofi and Regeneron’s Dupixent, for instance, is approved to treat COPD exacerbations in patients with high eosinophil counts, but not low ones. Meanwhile, the future has become cloudier for other next-gen IL-33 candidates from Sanofi and Regeneron, as well as Roche, which have suffered trial flops in recent years. One other potential ingredient for AstraZeneca’s success in its duo of studies was that the company was “ambitious in the trial design, willing to look at an all-comers population,” Barr said, “and willing to enroll the most severe patients.” Prior studies for would-be biologics rivals in COPD “avoided enrolling” those patients, she pointed out. She also highlighted the Big Pharma’s painstaking design of exacerbations in its trial, which “gave us a very rigorous readout,” and pointed to “the extra effort and investment” the company put in to understand the effect of mucus plugs in patients. Barr described mucus production as a “key feature in disease diversity,” noting that mucus plugs—obstructing clumps of mucus that block patients’ airways—are associated with worse outcomes in COPD. In its data announcement, AstraZeneca noted that an integrated analysis of Oberon and Titania found tozorakimab “demonstrated a reduction in patients’ mucus plug score,” with the pharma claiming its biologic is the first to deliver such results in a broad COPD population. “So being able to reduce those mucus plugs, we expect, is an important part of driving benefit for patients who are living with COPD,” Barr said. Again touching on the breadth of the study populations, Barr added that tozorakimab “worked across all eosinophil levels in both current and former smokers across all levels of lung function,” which she suggested “really simplifies decision-making for clinicians, and it allows them to offer therapy to the broadest possible patient population.” In the highest patient eosinophil count group, tozorakimab helped chart a 43% reduction in exacerbation risk, which Barr stressed were “unprecedented data.” In the mid-level group, AZ’s drug delivered a 23% reduction and, in the lowest group, a 34% reduction in eosinophils, which Barr said suggests efficacy “in all patient subgroups.” As for AZ’s recent guidance upgrade on the medicine’s sales opportunity, the lift from a $3 billion to $5 billion range to $5 billion plus was informed by multiple factors, Barr said, including the fact that “in 2024, there were multiple competitors, and there aren’t anymore.” Additionally, “we know that this is a massive unmet medical need, and this is a really incredible set of data that we think will be very convincing to the clinical community,” Barr said. Looking ahead to a potential evolution of the COPD treatment landscape, Barr noted that most patients start treatment in the community with an option like a triple therapy, and for them, having an option like AstraZeneca’s inhaler Breztri will remain a “really important part” of that journey. But of the patients uncontrolled on triple therapy, which Barr described as “about half of them today,” just a “small fraction” are currently eligible for biologic therapy, which she emphasized AstraZeneca is working to change. Understanding that COPD is not a “one-size-fits-all” disease, AstraZeneca is also looking at its antibody drug Tezspire for patients with T2-driven disease, and the company continues to think about new mechanisms for tackling COPD through both systemic and inhaled drugs, Barr said.

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Sep 8 • 10:50 AM EDT • Science • fiercebiotech.com
Seiche Launches Marine Science And Technology Department With Three New Leaders

Seiche has established a Marine Science & Technology Department uniting marine mammal specialists, acousticians, and engineers under three new department heads. The move expands the company's scientific and technical capabilities across offshore wind, renewable energy, and broader marine environmental monitoring.

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Sep 8 • 10:21 AM EDT • Science • oceannews.com
Arizona Diamondbacks News 9/8: Labor Yay!

Recaps from a wild Labor Day win as well as news confirming Burnes return

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Sep 8 • 10:00 AM EDT • Sports • sports.yahoo.com
Vertical Aerospace’s eVTOL Can Fly. The Passenger Business Is Still Unproven

Vertical Aerospace has made real flight progress, but five years of recapitalization show why passenger economics remain the harder test.

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Sep 8 • 9:37 AM EDT • Business • cleantechnica.com
Deconstructing LSD for Therapeutic Discoveries

UC Davis researchers have stripped down LSD to the base features responsible for its hallucinogenic and therapeutic effects.

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Sep 8 • 9:30 AM EDT • Science • ucdavis.edu
Harrison Smith Returns — And the Cap Gets Complicated

Harrison Smith's $12.25M return, cap concerns, bold predictions, and an NFL Rivalry Weekend pitch.

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Sep 8 • 9:25 AM EDT • Sports • sports.yahoo.com