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Forty Under 40: Lauren Blass
Lauren Blass started working in commercial real estate after a 15-year career in commerce marketing. The Bentonville native took a sabbatical for more than a year after serving as senior...
Forty Under 40: Lauren Blass
Lauren Blass started working in commercial real estate after a 15-year career in commerce marketing. The Bentonville native took a sabbatical for more than a year after serving as senior...
Inter vs. Real Betis, where to watch it on TV
The beginning of the new season is getting closer and Inter are preparing for their final friendly before the league starts: on Saturday 15 August at 19:30 CEST, the Nerazzurri will face Real Betis at...
AbCellera women’s health data top ‘most aggressive upside scenario,’ putting Astellas and Bayer on notice
AbCellera has reported phase 2 results “beyond even the most aggressive upside scenario” that its CEO dared to consider, boosting the biotech’s chances of challenging Astellas and Bayer for a women’s health market. The phase 2 clinical trial compared ABCL635, an antibody targeting NK3R, to placebo in patients with hot flashes caused by menopause. Investigators enrolled 92 postmenopausal women experiencing a mean of about 10 moderate or severe hot flashes per day. By Week 4, the number of moderate or severe hot flashes had fallen by a mean of 8.8 on ABCL635 and by 3.5 on placebo. That statistically significant, placebo-adjusted reduction of 5.3 hit the trial’s primary endpoint. The level of efficacy also cleared the bar set by existing drugs. While cross-trial comparisons can be misleading, AbCellera CEO Carl Hansen, Ph.D., had seen enough to start hyping the program. “We now view ABCL635 as a potential best-in-class non-hormonal therapy with strong differentiation against approved NK3R competitors across all important dimensions, including efficacy, safety, dosing and convenience,” Hansen said on a Monday morning conference call with investors to discuss the data. “We believe ABCL635 is now a highly de-risked program.” Last week, Hansen used AbCellera’s earnings call to set expectations for readout, with the CEO defining success as a clean safety profile and efficacy comparable to the two approved small molecules. The data vaulted over that bar. Astellas linked (PDF) one of the small molecules, Veozah, to placebo-adjusted reductions in hot flash frequency of 2.1 and 2.6 at Week 4 of its two phase 3 trials. Bayer reported (PDF) placebo-adjusted reductions of 3.04 and 3.29 at Week 4 of pivotal studies for its small molecule, Lynkuet. At 5.3, the placebo-adjusted reduction in AbCellera’s trial comfortably cleared the standard set by the incumbents. Veozah and Lynkuet came to market based on evidence of their ability to reduce the frequency and severity of hot flashes. AbCellera’s phase 2 study covered both endpoints, with the Canadian biotech reporting a mean reduction in severity of 1.4 points at Week 4 on ABCL635, compared to 0.3 points for placebo. Again, the placebo-adjusted result compares favorably to data on Veozah and Lynkuet. Analysts shared Hansen’s enthusiasm for the data. The phase 2 results “firmly validate ABCL635 as a potentially best-in-class treatment,” BMO Capital Markets analysts said in a note to investors Monday. ABCL635’s apparent efficacy edge “is likely attributable to the higher dosing/target engagement the asset is able to reach vs. the oral agents due to its wider therapeutic index,” the analysts added. The analysts, who model $2.3 billion in unadjusted peak sales for ABCL635, flagged the safety profile as another positive of the phase 2 readout. While Veozah carries a boxed warning for liver damage, nobody on ABCL635 in the phase 2 trial had elevated liver enzymes or bilirubin values. If replicated in phase 3, the lack of a liver signal could allow approval without the monitoring requirements imposed on Veozah. Investors appeared equally enthused, sending AbCellera's stock up 32% to $9.21 in premarket trading Monday from a Friday closing price of $6.93. Next, AbCellera will collect the Week 12 data and talk to its advisors about further development. The results open up “a wide variety of possibilities of how we might take this forward into phase 3 studies to truly maximize the value of the asset and make sure that ABCL635 is able to demonstrate its differentiation potential,” Sarah Noonberg, M.D., Ph.D., AbCellera’s chief medical officer, told investors.
How Troy Jackson went from Maine logger to the Democratic nominee for Senate
Troy Jackson's path to politics started during his time as a logger in Maine's north woods. Now he's the Democrat challenging five-term Republican Susan Collins for a Senate seat that could determine control of the chamber in November.
Should Seahawks Sign Controversial Lions First-Round Pick Terrion Arnold?
Seattle scouts a potential defensive cornerstone as the former Crimson Tide standout seeks a fresh start following his release from Detroit, adding intrigue to an evolving secondary.
Samsung starts early testing of One UI 9.5 for Galaxy S26 series
Samsung is already testing One UI 9.5 for the Galaxy S26 series. One UI 9.0, based on Android 17, officially debuted earlier this month with Samsung's new Galax
This sports retailer's turnaround is just getting started, Wells Fargo says
Wells Fargo's price target for Dick's Sporting Goods implies 15% upside from Friday's close, a new analyst note shows.
Who really needs testosterone?
The military plans to start screening service members for low testosterone, and social media is overflowing with claims about testosterone therapy. But who actually needs it?
Ball wants improvement as Torquay start with draw
Torquay United manager Jimmy Ball says his side's second-half performance cost them as they drew 1-1 with Horsham in their National League South opener.
Commentary: Schools keep calling moms, reinforcing old assumptions and roles
The start of the school year brings a familiar list of responsibilities for parents: buying school supplies, keeping track of forms, coordinating transportation and responding to a steady stream of
Can This Squad Really Get Promoted? I’m Not Convinced
Reading FC’s starting XI looks good, but surely the bench is just as important?
Meet the Inaugural Business Titans
What does it take to be a Business Titan? A corner office and a big title are a good start, but they are hardly enough.
A man accused of orchestrating Tupac Shakur's 1996 killing is on trial. Here's what to know
The trial of a man accused of orchestrating the 1996 killing of rapper Tupac Shakur starts this week. The unsolved case has gripped the hip-hop world for 30 years. The trial is expected to last about...
OPINION: Business formation fee cuts spur entrepreneurship
Opinion: New Jersey cut business formation fees to encourage entrepreneurship and make it easier for startups to launch and stay compliant.
Former Bengals draft pick suspended by NFL
A former high-profile Bengals draft pick will start next season suspended.
Eagles' QB2 Battle Is Still Too Close to Call
One of the key training camp battles for the Philadelphia Eagles was who would be the backup for Jalen Hurts: Tanner McKee or Andy Dalton. While Dalton currently has the slight edge, the race is not over just yet. Last season, McKee served as the second quarterback, starting in Week 18 against the Washington Commanders when the Eagles decided to rest their starters heading into the playoffs.
Shein finds there's no place like China after Vietnam warehouse experiment disappoints
Shein started encouraging its biggest Chinese suppliers to set up manufacturing bases in Vietnam. But things did not go to plan.
Haywood Road repaving begins as west Asheville businesses and drivers brace for disruption
Starting today, a 2-mile stretch of Haywood Road in west Asheville will close for repaving work.
Angels Crushed By Miami, 12-3, As Rodriguez Struggles Again
The Los Angeles Angels aren't doing so well in their efforts to turn around starter Grayson Rodriguez.
Jose Felix’s impact on Jet Sports Training makes Southside fitness business limitless
A conversation with Bobby Rodriguez at the wedding of Jose Felix's cousin in 2017 led to a dinner meeting at the restaurant No Anchovies between the two Sunnyside High School graduates to discuss further the possibility of collaborating on a local fitness center. No Anchovies became the starting point of no giving up when it
Brian Schottenheimer’s challenge keeps door open in Cowboys’ LT competition
Dallas Cowboys head coach Brian Schottenheimer spoke on the state of the team's battle for the left tackle starting job.
Umpire ejects starting pitcher before Braves-Yankees game begins
The left-hander didn't like a balk call the day before he was ejected
iPhone 17 set to break a record no flagship has touched in 15 years
When Apple released the iPhone 17 last September, the timer started for the new flagship model breaking a record set...
Brewers' Kyle Harrison: Good to start Tuesday
Brewers' Kyle Harrison: Good to start Tuesday
Could this everyday habit really increase your risk of Alzheimer’s? Science finally answers - Futura-Sciences
Where Did This Nose-Picking and Alzheimer’s Rumor Start? Over the past few years, a persistent rumor has resurfaced: picking your nose could supposedly increase your risk of developing Alzheimer’s disease. What’s behind this eyebrow-raising claim? It all traces back to a scientific study on mice, published in the journal Nature...
Pirates' Endy Rodriguez: Missing out on another start
Pirates' Endy Rodriguez: Missing out on another start
The Real Purpose of Rams' Preseason
The Los Angeles Rams have taken a cautious approach to the preseason, and in 2026, that strategy should continue. The Rams rely on training camp, Woodland Hills sessions and joint practices to sharpen their top players before the opener. The same likely goes for most starters, including stars such as Puka Nacua and Myles Garrett.
Consider becoming a referee for Iowa school sports
I started officiating in the fall of 1978. My football crew has two gentlemen who are in their 70s. Two gentlemen are in their 50s. And one gentleman is about
The Guardian view on the two cultures: bridge the divide, starting with A-levels
Editorial: Seventy years after CP Snow warned of estrangement between the sciences and arts, breadth in education should be encouraged
Phillies' Don Mattingly Shares Good News on Andrew Painter
Andrew Painter is expected to make his next scheduled start despite exiting Wednesday's game early.
California Forever hopes for last minute help from state lawmakers, Gov. Newsom
The developers of a new, proposed town called California Forever have been struggling to get it started and are now hoping to get some last-minute help from state lawmakers and the governor to move it forward.
'Tomorrow the real business starts'
New Manchester City boss Enzo Maresca says he is "very happy" with his opening three pre-season friendlies in charge as his players are "open-minded" to his style of play. City rounded off their Asian tour with a 3-1 victory over Atletico Madrid in South Korea on Sunday. Maresca's side trailed 1-0 at half-time but a double from Omar Marmoush, both assisted by the impressive Antoine Semenyo, and a late Rayan Ait-Nouri strike secured the comeback win.
Panthers sign QB Kyle Trask with Hall of Fame game hero Haynes King sidelined
Trask gives the Panthers a third QB behind starter Bryce Young and backup Kenny Pickett.
Bills news: Recapping Return of the Blue & Red
In the first public event at the new stadium, the secondary made big plays and Josh Allen rebounded from a poor start.
He Died Before Beating Zelda. She’s Finishing What He Started.
How The Legend of Zelda: Tears of the Kingdom allowed one young woman to process the death of a loved one
Who's Next? TCU's Best Bet to Restart Its NBA Pipeline
After a rare draft drought, Xavier Edmonds and Gavin Sykes headline a new wave of Horned Frogs aiming to impress scouts and restore TCU’s professional pipeline.
FULL SHOW: Inside INdiana Business 8/9/26
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A Shark Tanker’s Advice On Avoiding New-Business Overwhelm
As more Americans look to start businesses to shore up their income and career possibilities, they're discovering it's not as easy as it may look. Inventor Raquel Graham, who made the transition, offers seven steps on how to turn an idea into a real business.
Simulating FSU’s 2026 season in College Football 27
College Football 27 has dropped, and I am having a blast with it. I’m rebuilding Kent State on Heisman difficulty, and I don’t want to brag or anything, but we started out 1-6. But since this is an FSU site, I thought it would be fun to give the Seminoles a proper simulation to see […]
Where to watch Phoenix Mercury vs Washington Mystics on Aug. 9: TV channel, start time and streaming
Here's how to watch Sunday's Washington Mystics vs Phoenix Mercury game, including start times, TV channels, scores and how to stream.
Delaware opens Fall EDGE Grant Competition
Delaware's fall EDGE Grant Competition opens Aug. 11. According to the Division of Small Business, $1.15 million in funding is available for eligible startups and small businesses.
Here’s When Apple Will Reveal Its iPhone 18 Pro Special Event
Apple’s next iPhones will go on sale in just over a month. But when should you start looking out for the confirmation of the special event? Here’s all you need to know.
As Trump drastically rolls back rules for Head Start, some Republicans are wary
GOP Sens. Lisa Murkowski, Jim Justice and Thom Tillis are among the lawmakers signaling reservations at the idea of a preschool program overhaul.
Benson Boone concert at Golden 1 Center postponed due to health reasons
Benson Boone's concert at the Golden 1 Center on Saturday was officially postponed less than an hour before it was scheduled to start.
Can Sam Roush Become the Chicago Bears' TE2 This Season?
One of the biggest strengths of the Chicago Bears is tight end right now. You have Colston Loveland at the top, who’s the clear TE1. With Loveland being drafted 10th overall in the 2025 NFL Draft and having 713 yards in his rookie season, there’s not much debate for the starting spot.
Could Orlando Magic Have a Huge Roster Shakeup?
Pressure mounts as postseason failures linger. While the star duo remains secure, underwhelming results could force the front office to sacrifice key starters to salvage Orlando’s timeline.
American Airlines Just Made It Harder for Elite Flyers to Get Free Business-Class Upgrades
Starting August 25, AAdvantage members flying economy are losing a valuable perk on popular Hawaii and coast-to-coast routes: a chance to score a complimentary lie-flat seat.
Astros' Cristian Javier: Getting another start Sunday
Astros' Cristian Javier: Getting another start Sunday
Former Washington football star prioritizing health over starting job
Former UW star Michael Penix Jr. is nearing a return from a knee injury, and a battle for Atlanta's QB1 job.
Cubs roster move: Clay Holmes added, Braxton Garrett optioned
The Cubs have added Saturday's starter to the active roster.
Bromley 1-1 Reading (4-5 Pens): A Scattergun Start
A mixed performance but good result as Reading make it through to the second round of the League Cup.
"Honestly, before the start of the playoffs, our whole …
"Honestly, before the start of the playoffs, our whole …
I left my marriage at 62 and moved to Greece alone
Kati Gyselinck traded her secure, but unfulfilled lifestyle for a fresh start in another country. She downsized and found joy in the simpler things.
Mike Tomlin hasn't thought about returning to coaching, yet
For now, he doesn't miss it. That could change when the regular season starts.
Mike Tomlin hasn't thought about returning to coaching, yet
For now, he doesn't miss it. That could change when the regular season starts.
How Troy Jackson went from Maine logger to the Democratic nominee for Senate against Susan Collins
Troy Jackson’s path to politics started during his time as a logger in Maine’s north woods
Pirates lose their fourth in a row as Carmen Mlodzinski struggles in his first start since May
If the Pirates hoped to rid the stench of their disappointing road trip around the Midwest, Friday night’s series opener against the New York Mets...
Where to watch Chicago Cubs vs Kansas City Royals: TV channel, start time, streaming for Aug. 8
Here's how to watch Saturday's Kansas City Royals vs Chicago Cubs game, including start times, TV channels, scores and how to stream.
Where to watch Las Vegas Aces vs Minnesota Lynx on Aug. 8: TV channel, start time and streaming
Here's how to watch Saturday's Minnesota Lynx vs Las Vegas Aces game, including start times, TV channels, scores and how to stream.
Burcum: Putting Flanagan and Craig to the test on health care
Columnist Jill Burcum asked the DFL candidates for their positions on several pressing Minnesota health care issues to provide a more detailed look at how they’d approach the job in the U.S. Senate.
Here’s When Apple Will Reveal Its iPhone 18 Pro Special Event
Apple’s next iPhones will go on sale in just over a month. But when should you start looking out for the confirmation of the special event? Here’s all you need to know.
Red Sox Make Adley Rutschman Announcement as Debut Nears
Boston Red Sox catcher Adley Rutschman will be making a rehab start in Worcester on Saturday as he nears his debut. The post Red Sox Make Adley Rutschman Announcement as Debut Nears appeared first on HEAVY.
How a duck's friendship helped a New York family's golden retriever overcome health issues: "She started smiling again"
Scientists create OnlyFans account for marmots to fund research
UCLA professor Daniel Blumstein and his team started an OnlyFans account to raise money for their research amid government funding cuts
New uncertainties as owner of stricken Longview mill posts quarterly loss
It's unclear whether financial challenges at Japan-based Nippon Paper will affect the restart process at its Longview mill, which shut down following a fatal accident in May.
Palmetto Sports Daily: Panthers win preseason thriller, Gamecocks kick off fall camp
The crew recaps a thrilling win for the Panthers in Canton and dishes more on the start of fall camp for Gamecock football.
Clay Travis set to start new sports, politics site after leaving Outkick
Conservative commentator, radio host remains contributor to Fox News, Fox Sports
I've Built 7 Companies in a Mid-Sized Market. Here's How It Gave Me an Advantage the Big Cities Couldn't.
You don't have to build your business in a big metro. Mid-sized cities have their own unique benefits for founders.
iPhone 18 Pro rumor roundup: 2nm A20 chip, C2 modem, under-display Face ID
Apple's iPhone 18 Pro is right around the corner, and the rumor mill started earlier than normal. Here's what you need to know.
Tesla Rolls Out Rare Software Update to Mobile Connectors
In an unexpected hardware drop, Tesla has started pushing a firmware update for its portable Mobile Connector charging units
WR Cyrus Allen back at practice for Chiefs
Chiefs rookie wide receiver Cyrus Allen's hot start to training camp was interrupted by a shin injury last weekend, but Allen's time away from the field came to an end on Friday.
Eagles GM Howie Roseman Compares Struggling Rookie to All-Pro
Howie Roseman’s latest draft class isn’t looking great to start the 2026 NFL training camp sessions for the Philadelphia Eagles. After spending high-end picks on Makai Lemon and Eli Stowers, both rookies have had their fair share of struggles throughout the first week of camp. The former started off with a quiet run before going […] The post Eagles GM Howie Roseman Compares Struggling Rookie to All-Pro appeared first on HEAVY.
Mets' Robert Stock: Receiving another start
Mets' Robert Stock: Receiving another start
Veteran Janet Meyer invests in Chattanooga firm through Veterans Entrepreneurship Program - Gary W. Rollins College of Business
Janet Meyers built community and confidence in her startup company through the Veterans Entrepreneurship Program at UTC.
Doctor Reveals the Best Age to Start Building Bone Density
In TODAY.com’s Expert Tip of the Day, a doctor shares the best age to start boosting bone density, which deteriorates as you age.
Africa doesn’t just need more startups. It needs ways to help viable businesses survive
The frequent closure of African small businesses threatens the fabric of entrepreneurship on which the continent relies – but the diaspora could step in.
Energy politics prominent in big South Carolina Senate primary
Upstarts are seizing on artificial intelligence infrastructure and solar manufacturing to undercut their rivals in a crowded Republican contest.
Déjà Vu Has a Stranger, Lesser-Known Opposite – And Scientists May Have Just Found Where It Starts
It's uncanny.
Is population growth still necessary for startup growth? Louisiana offers a messy test case
Every parish saw new business filings rise, but data from New Orleans, Lafayette and Baton Rouge shows why founder support matters in a shrinking region.
Nationals Make Waiver Claim, Get Bad News on Connelly Early
The Washington Nationals added one to the roster, updated the status of a projected starter while another cleared waivers
Music Theatre of Madison hopes to inspire with ‘Trevor: The Musical’
“Trevor: The Musical” staged by Music Theatre of Madison starts its 20th anniversary season with the company’s first-ever show in Overture Center.
British Engineering Firm Goodwin Starts Strategic Review
Goodwin Plc, a family-run UK engineering firm founded more than 140 years ago, has started a strategic review that may lead to the sale of a large chunk of a key business.
Padres' Walker Buehler: Logs another short start
Padres' Walker Buehler: Logs another short start
Royals' Michael Wacha: Just misses quality start
Royals' Michael Wacha: Just misses quality start
SHARE program allows students to experience medicine and science
As Jayson Smith approached his sophomore year at Nettleton High School, he knew he wanted to pursue a career in medicine, but he didn’t really know where to start. “I...
Mike LaFleur hilariously roasts brother Matt before HOF game
Mike LaFleur surprises his brother Matt before the start of the 2026 NFL Hall of Fame Game between the Cardinals and Panthers
Scientists Are Starting To Understand The 'Largest Biomechanical Event on Earth': Whales Hunting For Food on a Single Breath
If your heart slowed that much, you'd probably pass out.
Virginia businesses sue to block new THC regulations set to take effect this month
Starting on Aug. 16, hemp products in Virginia cannot exceed more than 2 milligrams of THC per package. Supporters say it's a safety issues, but some local businesses the new regulations could force them to take massive amounts of products off the shelves.
New Orleans Saints Rookie Wide Receiver and Son of WWE Star Suspended 6 Games
New Orleans Saints rookie wide receiver Brock Rechsteiner catches a six game suspension from the NFL league office. While the current reason for the suspension in unknown, suspensions for performance enhancing drugs start at four games. They increase to six games when there is an attempted manipulation. Brock Rechsteiner has been suspended by the Commissioner […] The post New Orleans Saints Rookie Wide Receiver and Son of WWE Star Suspended 6 Games appeared first on HEAVY.
Talented Giants’ 14-Game Starter Suffers Injury Setback
New York Giants head coach John Harbaugh said an injury to 14-game starter Dru Phillips could result in signing another cornerback. The post Talented Giants’ 14-Game Starter Suffers Injury Setback appeared first on HEAVY.
High school sports tryouts and practices kick off Aug. 17
Our high school fall sports season will kick off on Monday, Aug. 17, with tryouts and practices beginning for high school football. Tryouts and practices for all other high school sports, including cheerleading, boys' soccer, girls' soccer, boys' cross country, girls' cross country, girls' tennis, girls' swimming and diving and volleyball, will begin on Monday, Aug. 24. Tryouts and practice schedules Tryout and practice schedules are available via the practice schedules button located on the fall sports page of our website. Please note that practice schedules are subject to change due to inclement weather or unanticipated circumstances. Registration information As a reminder, students and parents must fill out all required paperwork on Final Forms to participate in tryouts and practices. A physical conducted within the last 12 months is mandatory for any student interested in trying out for an athletic team and must be uploaded into Final Forms platform. Families are encouraged to get a completed physical from their child's physician. If you are unable to get a physical from your child's physician, you can schedule a free physical with Whitney Young's school-based health center by calling (518) 573-2556. Additionally, the district physician will also be available to facilitate sports physicals at Albany High in room 4253 on the following dates: Monday, Aug. 17 from 10:30 a.m.-3 p.m. Thursday, Aug. 20 from 10:30 a.m.-3 p.m. Sports physicals on Aug. 17 and 20 are free and no appointment is necessary. Academic Eligibility As a reminder, students must be in good academic standing to participate in athletics. Academic eligibility will start at the beginning of each academic year. Eligibility is determined based on quarterly grades, and interim progress reports will serve as an important academic checkpoint for all student‑athletes. For additional details about academic eligibility, please see our Athletic Code of Conduct. Falcons, we can't wait to see you soar this fall season!
Environmental groups challenge FCC approval of startup’s plan to beam on-demand sunlight from space
While the FCC approved only a single test mission, the groups argue it could pave the way for a much larger constellation of satellites in the future.
Pirates' Carmen Mlodzinski: Starting Friday's game
Pirates' Carmen Mlodzinski: Starting Friday's game