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California’s next governor will face destabilizing surge in uninsured
Should Xavier Becerra cruise to victory in the California governor's race in November, as polling suggests, he will face what may be the steepest decline in health insurance coverage in a...
Making Sense of Phoenix Suns' Biggest Storyline This Season
As roster shifts trade elite shooting for raw athleticism, Phoenix faces a high-stakes gamble on Miles Bridges to elevate their ceiling amidst looming threats of early-season regression.
Pirates Trying to Find This Balance With Konnor Griffin
The Pittsburgh Pirates need Konnor Griffin in the lineup, while also being mindful that he's still coming back from injury.
Geologists reveal the Americas collided millions of years earlier than thought
Volcanic rocks in Colombia are rewriting the timeline of the collision between Central and South America. Their magnetic signatures show that major tectonic deformation had already weakened by the late Miocene, suggesting the most intense collision occurred earlier than previously believed.
The Nonlinear Science Behind Large Language Models
LLMs are black boxes, but the principles that govern them are not. Read this article for a detailed introduction to chaos and complexity theory applied to LLMs.
Classic, luxury car business plans to move into old Stevenson Lumber building
MONROE, Conn. --- Carsation, a used car dealership specializing in classic and luxury automobiles, from Porsches and Mercedes to BMWs and Land Rovers, plans to renovate the former Stevenson Lumber building at 1545 Monroe Turnpike to display its cars in a showroom for customers, though the vast majority of its business is done online. Duane
Alex Michelsen’s Mysterious Girlfriend Draws Attention at US Open
Alex Michelsen and his girlfriend, Caroline, continue to keep a low profile during his successful run at the 2026 US Open. The post Alex Michelsen’s Mysterious Girlfriend Draws Attention at US Open appeared first on HEAVY.
The trail of clues that our planet might be heating faster than we realised
A curious online row over this summer's heatwaves points to a wider - and worrying - shift in climate science.
The trail of clues that our planet might be heating faster than we realised
A curious online row over this summer's heatwaves points to a wider - and worrying - shift in climate science.
All North Carolina student IDs will have mental health resources printed on them as part of the Student Helpline Act
RALEIGH, N.C. (WNCN) — Today is 988 Day, a nationwide event dedicated to promoting mental health support and suicide prevention through the 988 Suicide & Crisis Lifeline, and now, in North Caro…
D-backs @ Royals discussion
Today’s Lineups DIAMONDBACKS ROYALS Lars Nootbaar – DH Carter Jensen – C Ketel Marte – 2B Bobby Witt – SS Gabriel Moreno – C Vinnie Pasquantino – 1B Geraldo Perdomo – SS Salvador Perez – DH Corbin Carroll – RF Michael Massey – 2B Nolan Arenado – 3B Nick Loftin – 3B Tommy Troy – […]
Why was Corbin Carroll suddenly scratched from the Diamondbacks’ lineup?
KANSAS CITY – In a sudden move before Tuesday night’s matchup for the Arizona Diamondbacks in Kansas City against the Royals, Corbin Carroll has been scratched from the lineup. Jun 10, 2026; Miami, Florida, USA; Arizona right fielder Carroll (7) rounds past second base against the Miami Marlins during the first inning at loanDepot Park.
Vallejo’s Empress Theatre amps up entertainment offerings, dining
“The idea is simple: there should be something happening often enough that people throughout Vallejo, Solano County, and the greater Bay Area can make the Empress part of their regular week,” says the Empress Threatre.
Connect at Clyde event fosters networking opportunities with business leaders
It was all business today at Clyde Iron Works for a luncheon, to talk networking and opportunities.
The 98 Biggest TV Show Flops, Bombs and Misses in the First Half of 2026
(Welcome to the Entertainment Strategy Guy, a newsletter on the entertainment industry and business strategy. I write a weekly Streaming Ratings Report and a bi-weekly strategy column, along with occasional deep dives into other topics, like today’s article. Please subscribe.) In July, I updated my look at how the “streaming bubble” popped since 2023, showing the decline in streaming TV shows over time. But after compiling and analyzing and writing about over one hundred TV show flops in the first half of 2026—I counted 99 “nominees” and there are even more honorable mentions—I couldn’t have told you that the number of shows is going down. When it comes to scripted, English-language TV shows, it feels like we have as many bombs as ever. I don’t keep a specific count, but some streamers probably had as many flops as they’ve ever had.1 That’s right, it’s time for part two of my analysis of the biggest flops, bombs and misses on streaming in the first half of 2026. Two weeks ago, I took a look at films. Today, TV shows. If you want to read the full methodology for how I assemble this list, you can find it at the bottom of this article. In short, this list is… ...scripted and unscripted TV shows,...from the nine major streamers,...in the US (using US-only ratings),...excluding true crime, kids and foreign-language shows,...that got no/poor ratings,...from Jan-2026 to the end of June-2026. Reminder: this article does not represent my personal opinion—many of these shows are great!—but I follow the data, and a miss is a miss and a bomb is a bomb. Also, price matters. If a TV show costs north of $100 million, it needs to get lots and lots of streaming viewership to justify that budget. As with past editions, I ordered this list by streamer, going from best (fewest flops) to worst (the most misses)—taking the size of the flops into consideration—and like the last edition, three or four streamers vied to take the win/loss of having the most flops. (But the actual winner is no surprise.) I try to avoid tooting my own horn too much, but seriously, in just under 5,000 words (including the methodology section) I provide a mostly comprehensive overview of the eight major streamers (Netflix, Disney+, Prime Video, Hulu, HBO Max, Peacock, Paramount+, and Apple TV) for the first half of the year, mentioning most of their hits and all their misses. It summarizes the entire first half of 2026! If you want to support this work, please subscribe. Subscribe Tubi Big Mood Boarders The Freak Brothers Twenty Twenty Six Honorable Mentions: Busted on Bodycam, Deestroying the Pitch, Destination World Cup 2026 I don’t think that Tubi spends all that much making or (mostly) licensing these original TV shows—Big Mood, Boarders and Twenty Twenty Six all come from the UK—but they’re not free and they didn’t chart anywhere. Winner: The Freak Brothers Have you even heard of this show? It’s an animated comedy...that’s on its third season! And Pete Davidson, Woody Harrelson, John Goodman and Tiffany Haddish all provide voice talent for it. Yes, animated shows don’t cost as much as live action shows, but cheap isn’t free! So a show with this level of talent needs to perform better. Disney+ Daredevil: Born Again Star Wars: Maul – Shadow Lord Honorable Mentions: Behind the Attraction, Donna Hay Coastal Celebrations, We Call It Imagineering Disney+ doesn’t make all that many original shows anymore. They had two flops, and one was animated. Their one not-a-miss show, Wonder Man, got just good enough viewership to not be considered a “miss”...but it’s since been cancelled. At this point, Disney has pivoted entirely away from making big budget TV shows for Disney+ to making...almost nothing for Disney+? Sure, Disney’s spending circa 2019-2022 was unsustainable, but now they’re pivoting too far in the other direction. At some point, Disney needs to stop shifting strategies so wildly. Really, Disney should have made fewer shows for Disney+ at launch and the shows they did make at that time needed to be made at more reasonable budgets. And they should adopt that strategy now. Winner: Daredevil: Born Again Daredevil, the Marvel Comics character, is on my personal Mount Rushmore of favorite superheroes, so it pains me to give him the win/loss today, but this show deserves it. I’ll repeat my hot take from last spring: “Based on his popularity, Daredevil should be in movies, and probably ones that cost a lot less than the MCU’s usual price tag. Disney/Bob Iger/Ike Perlmutter (who, based on reporting, made the decision) made a huge mistake selling TV shows to Netflix in the 2010s, thus limiting this character to the small screen. Daredevil could have anchored Marvel’s post-Infinity War plans, and if he did, the MCU would probably be in a better place than it is now.” HBO Max We’re just getting started with this issue, but the rest is for paid subscribers of the Entertainment Strategy Guy, so if you’d like to find out… What four streamers had the most misses... HBO’s strong start to 2026… The caveat to Peacock’s turnaround this year... Paramount+’s key man problem… What country isn’t delivering hits for Netflix or Hulu... The cavalcade of stars on a streamer where no one is watching their shows... Across nearly 5,000 words of analysis… And a lot more... ...please subscribe! We can only keep doing this great work with your support. If you’d like to read more about why you should subscribe, please read this article about the Streaming Ratings Report, why it matters, why you need it, and why we cover streaming ratings best.
Broncos host 2 linebackers and 2 safeties for tryouts
The Broncos brought in four free agent defenders for tryouts on Tuesday.
Washington’s Deuce Davis Continues Havoc at EDGE
Sunday afternoon saw the first reps that Russell "Deuce" Davis II has taken since his three-sack performance in the UCLA game of 2024. That year, he played just 34 defensive snaps before injuries sidelined him for all of 2025. In the Apple Cup, Davis recorded a sack on his first play back. He appeared on …
Shohei Ohtani’s Health Raises New Alarm After One-Game Dodgers Return
Los Angeles Dodgers star Shohei Ohtani is out of the lineup just one day after returning, sparking increased alarm.
Cardinal Health (CAH) Declines More Than Market: Some Information for Investors
In the latest trading session, Cardinal Health (CAH) closed at $240.49, marking a -2.71% move from the previous day.
Billy Joel mourns friend and former drummer Jon Small
NEW YORK — Billy Joel mourned the death of his friend and former bandmate, drummer Jon Small, on Monday. He was in his late 70s. “RIP Jon Small,” Joel posted
AMC will pay $120 million to settle 'Walking Dead' profits lawsuit
LOS ANGELES — AMC Global Media, the network behind the storied zombie franchise "The Walking Dead," has settled a yearslong profits lawsuit from the show's creator and producers. The New
LG TV shown capable of tracking user activity, even when offline
“It doesn’t cost a lot to store text forever.”...
Pritzker-backed PAC plans to bankroll anti-Trump candidates nationwide
The committee, called “Ready for the Fight” in reference to a line from Pritzker campaign speeches, launched today.
National 988 Day raises awareness for mental health support
September 8 is National 988 Day, dedicated to raising awareness about the 988 Suicide and Crisis Lifeline.
From Backyard Ziplines to Self-Driving Cars: UCLA Computer Science Student Develops Tools to Help Autonomous Vehicles Safely Share Information
One of the fondest childhood memories of Alexandra Markova was a weekend spent running around Home Depot with her father and three siblings.
Lori Loughlin is divorcing Mossimo Giannulli after 30 years together
“Full House” star Lori Loughlin is formally ending her nearly 30-year marriage to fashion designer Mossimo Giannulli. The 62-year-old sitcom actor said the pair separated on Aug. 31, 2025, according
September 10 Vallejo/Vacaville Arts-Entertainment Source: Activities
A National Day of Service and Remembrance is set for Saturday at 10 a.m. in Dixon.
TreVeyon Henderson ruled out for Week 1
TreVeyon Henderson will not be in the lineup for the Patriots in Week 1.
Red Dead Redemption 2 free expansion is a new story set within an alternate timeline
If you need more post-game content, you've found it.
S&P 500 falls as AI worries hit software makers
The S&P 500 declined as AI competition fears hit software stocks and Middle East tensions lifted oil prices, with investors eyeing upcoming inflation data.
Rams Reveal Aaron Donald’s Status for Season Opener in Australia
The Los Angeles Rams have made a decision as to whether star defensive lineman Aaron Donald will play in the season opener in Australia. The post Rams Reveal Aaron Donald’s Status for Season Opener in Australia appeared first on LA Sports Report.
Dario Russo's 'The Fox' Acquired By Aura Entertainment For Theaters
Aura Entertainment has acquired Dario Russo's 'The Fox,' starring Sam Neill, Olivia Colman & more with a theatrical release date set in December.
Abilities Fine Art Gala celebrates creativity, talent, inclusion
Families & Friends Reaching for Abilities (FFRA), in partnership with the Art Center of Citrus County, will present “A Kaleidoscope of Color,” an Abilities Fine Art Gala, on Friday, Sept.
988: September 8 marks nationwide awareness campaign for mental health crisis lifeline
Georgians are being asked to tell a friend about 988 as part of a nationwide campaign marking September 8.
Buffalo Bills name 6 captains for 2026 NFL season
Who joins quarterback Josh Allen and linebacker Terrell Bernard as an official captain for the Buffalo Bills in 2026?
At rally to save Academy of Natural Sciences museum, protesters urge Drexel to 'act like it's an emergency'
Local lawmakers and scientists outlined several options to preserve the museum, which is due to close Sept. 30.
Iconic Spurs entertainment tradition returns
Spurs fans will notice an electrifying new addition to the game day experience at Frost Bank Center this season. After eight long years, the iconic all-female dance group — the Silver Dancers — will grace the sidelines once again. Spurs Sports and Entertainment originally dismantled the team in 2018 after their 26th season due to...
Artist creates pop art paintings for charity
Quiet conversation intermixed with smooth jazz piano at Asbury United Methodist Church on Friday evening, the old sanctuary providing shelter from the pounding rain for the art enthusiasts gathered within.
Luke Fickell Updates Badgers' O-Line Health, Evaluates Week 1 Performance
Wisconsin's head coach provided health updates and an evaluation of his offensive front.
Summerfest announces 1st 2027 headliner: Zac Brown Band
MILWAUKEE (WKOW) -- The organizers of Summerfest announced the music festival's first headliner for 2027: Zac Brown Band.
Dallas mayor sounds alarm on the 'grave threat' facing America's cities
Dallas Mayor Eric Johnson warns a socialist movement threatens U.S. cities and the economy, touting his city's financial services growth and free markets.
As measles cases rise, Lancaster County officials point to information gap
Communication and information-sharing among agencies could be better with regard to Lancaster County’s measles outbreak, officials said during a recent Lancaster County Health Advisory Council meeting.
There is room for improvement in information-sharing about measles outbreak, officials say
Communication and information-sharing among agencies could be better with regard to Lancaster County’s measles outbreak, officials said during a recent Lancaster County Health Advisory Council meeting.
Allegri counts on European 'motivation and adrenaline' for Napoli
Coach Massimiliano Allegri is hoping the arrival of Champions League football can help put Napoli on the right track after back-to-back defeats in Serie A. Victory on the opening day against Genoa has been undermined by successive defeats at the hands of Como and Inter Milan, leaving new boss Allegri looking for a reset when his side welcome Arsenal to Stadio Diego Armando Maradona on Wednesday evening.
Ram Getz & Michael Mortensen Launch i80 Entertainment (EXCLUSIVE)
Ram Getz and Michael Mortensen, partners at GM Management, have launched i80 Entertainment, a new independent production company.
US issues sweeping sanctions against Iranian airlines, foreign businesses
The Trump administration on Tuesday announced new sanctions against all of Iran’s airlines and nearly a dozen foreign companies doing business with Iran’s Mahan Air, which had earlier been sanction…
CONFIRMED lineups: Real Madrid vs Inter Milan, 2026 Champions League
Real Madrid have published their starting lineup for the upcoming match against Inter Milan in the Champions League. STARTING LINEUPS: Real Madrid starting XI: Courtois; Dumfries, Konaté, Huijsen, Cucurella; Valverde, Trent; Brahim, Bellingham, Vinicius; Mbappé. Inter Milan starting XI (TBC): Martínez; Bisseck, Stones, Bastoni; Luis Henrique, Barella, Calhanoglu, Jones, Carlos Ausgusto; Lautaro, Thuram. HOW TO […]
Stevie Wonder announces fall tour
DETROIT — Motown icon Stevie Wonder has announced fall tour dates, including a pair of concerts at Detroit's Fox Theatre. The tour marks the 50th anniversary of his 18th studio
Why Lewis Dunk Is STILL Brighton's Most Underrated Player
The veteran skipper remains the common denominator in Brighton’s success, transforming raw defensive partners into stars while proving he is the timeless heartbeat of the Seagulls’ backline.
From science to screen time: 4 key takeaways from the latest PISA results
Amid reading declines that included a 14-point drop for the U.S., researchers are looking at the role digital learning and AI may have played.
Apple Event Tomorrow: iPhone 18 Pro and iPhone Ultra Cheat Sheet
Apple's biggest event of the year is almost here, and all eyes are on Cupertino. With the first foldable iPhone expected to headline Apple's "Surprise and Shine" event on Wednesday, September 9, at 10:00 a.m. Pacific Time, the rumor mill has been running full throttle, fuelled by the biggest single design change in the life of the iPhone.
Health: The Fight For The Health Of 9/11 First Responders
A quarter century after 9/11, the health of those who responded to the attacks continues to be affected.Some 3,000 people died across three locations that day. An estimated 400,000 people were exposed to toxic contaminants and risked physical injury in the hours and days that followed. That’s according to data from the Centers for Disease Control and Prevention.Since the dust and debris have settled, more than 96,000 have been diagnosed with physical and mental health conditions related to 9/11.In 2010, President Barack Obama signed the James Zadroga 9/11 Health and Compensation Act, establishing the World Trade Center Health Program and reopening the 9/11 Victims Compensation Fund. Today, more than 150,000 people are enrolled in the program.But that program wouldn’t exist without the advocacy of survivors and first responders who put their bodies and lives on the line following the attacks. How did that fight for care unfold?For more information about the Rutgers WTC Health Program, click here. And to learn more about applying, click here.Find more of our programs online. Listen to 1A sponsor-free by signing up for 1A+ at plus.npr.org/the1a.
Ink Business Unlimited vs. Spark Cash Select: Which is best?
The Ink Business Unlimited and Spark Cash Select both earn 1.5% cash back with no annual fee. But the Ink Business Unlimited is better for most businesses.
Bentley Awarded $235,000 to Strengthen Life Sciences Talent Pipeline
Bentley University will use $235,000 grant to prepare students for business roles in life sciences to meet Massachusetts workforce need.
Lancaster County judge hears challenge to Nebraska K-12, collegiate sports ballot measure
A Lincoln voter refiled a challenge this week to a ballot measure seeking to cement limits on public school sports participation to student-athletes’ sex at birth after the Nebraska Supreme Court declined to hear the lawsuit.
Small business optimism slips in August as sales, inflation concerns persist
Small business optimism declined in August as owners faced weaker sales, inflation and hiring challenges, according to NFIB’s latest survey.
US targets Iran’s airline industry as part of pressure campaign
The Trump administration took sweeping actions against Iran’s airline industry on Tuesday as part of its pressure campaign on Tehran.
National politics roundup
We’re digging into all the top headlines with local commentators on either side of the .
Peter Krause reflects on his decades-spanning television career: ‘I like to work’
From ‘Sports Night’ to ‘Six Feet Under’ to ‘9-1-1,’ Peter Krause has been busy for the past ... several decades. The veteran actor talk to EW ahead of his new show, ‘Line of Fire.’
“Line of Fire ”cast serves (justice) in exclusive EW cover portraits
The Hollingsworth family is not here to mess around.
Week 1 Reminded Us Why College Football Is the Best
College football is officially back. And somehow, Week 1 already gave us enough storylines for an entire season. The biggest statement came from LSU . Lane Kiffin’s debut couldn’t have gone much better, as No. 11 LSU absolutely destroyed Clemson 51-10 in Death Valley. LSU piled up 644 yards while holding Clemson to just 145.…
Your vote. Your child’s classroom. Your electric bill. Your water. Your health.
More than 95% of cases in this country are handled by state courts. And as the U.S. Supreme Court pushes fundamental questions about our freedoms back to the states, state courts and state constitutions are increasingly important protectors of our rights.But those protections only mean something if the judges sitting on our Supreme Court are willing to enforce them.
NFL Announces Halftime Act for Detroit Lions Munich Game
The NFL has announced Cage The Elephant as the halftime headliner for the Detroit Lions’ Nov. 15 game against the New England Patriots in Munich.
Review: SteelSeries Aeon Pro: The Infinite Battery Life, Dual-System Xbox and PC Controller Impresses, Despite Its High Price
Borrowing the best ideas from the firm's Arctis Nova Pro headset lineup.
\'Twilight\' film concert experience coming to Hershey; here\'s when tickets are on sale
Fans of the "Twilight" movies can experience the romance of Edward Cullen and Bella Swan all over again when the "Twilight in Concert" tour stops in Hershey in February 2027.
Christal Jordan has the latest in entertainment headlines
The Duke & Duchess of Sussex are back in the UK, and Phaedra Parks has a new beau. Keep up with Christal on social media @threalchristaljordan
The Row brings new retail, dining and entertainment to Heartwood
The Row, a new in-line retail center located in Poplar Place within Heartwood’s Town District, will bring a growing mix of dining, entertainment, services and specialty retail to one of the community’s most visible commercial areas at Exit 82.
‘Science at the Fifty-Third Degree’ humanizes research advancements through conversation
Episodes highlight the collaborative nature of science, and expand accessibility of discoveries happening at the university.
Fantasy Football studs n duds in Week 1
Avoid these week one duds, get them out of your lineup!
New report finds little short-term health risk from air pollutants in South Portland, Portland
Six years of air sampling found benzene levels above state guidelines at one location and elevated acrolein levels across the study area.
Roundup: Energy employment / Small business confidence / Maritime woes
Jobs in transition: Energy sector employment fell about 1% nationwide and in Louisiana from 2024 to 2025, with Louisiana losing 1,131 jobs to reach roughly 160,000 workers. The decline was driven largely by automation, policy changes affecting renewable energy, and shifting economics, while traditional energy industries such as coal and nuclear saw job growth. Despite […]
AZ's R&D chief Barr touts internal 'science success story' after IL-33 antibody's stellar showing in COPD
With a detailed data drop that AstraZeneca’s R&D chief described as an internal “science success story,” the British Big Pharma has secured an FDA priority review for what it believes could become a flagship biologic in chronic obstructive pulmonary disease (COPD). In detailed results from the late-stage Oberon and Titania trials—first teased in March and detailed in full at the European Respiratory Society Congress in Barcelona this week—the drugmaker laid out the extent of its IL-33 inhibitor’s potential to reduce moderate and severe exacerbations in a wide range of COPD patients still struggling with those “lung attacks,” as AstraZeneca’s Sharon Barr, Ph.D., called them, despite using standard-care inhaled therapy. In the headline results, a 300 mg dose of tozorakimab given once every four weeks curbed those moderate and severe exacerbations in the studies’ primary population of former smokers by 29% in the Oberon study and 34% in Titania. In the overall population of both current and former smokers, these reductions were 30% and 29%, respectively, versus placebo and inhaled standard of care. The benefits also extended to clinically meaningful exacerbation reductions in all prespecified patient subgroups and specifically turned up promising signals in patients across a range of blood eosinophil counts, with Barr telling Fierce that “it’s the details that make this even more exciting than the high-level results that we’ve already shared.” In fact, during AZ’s tozorakimab poster presentation at the ERS 2026 Congress this past weekend, attendees were so enamored by the data that event organizers had to encourage people to clear the room and look at the other presentations on offer, Barr said in an interview. “I think it really speaks to the fact that there is a lot of buzz around these data because the entire respiratory community has been so desperate for new therapies for these patients,” she explained. The respiratory disease continues to represent a “staggering unmet medical need,” Barr said, highlighting the COPD exacerbations that the Oberon and Titania studies homed in on, which she added carry a greater mortality risk than a heart attack. “When a patient has a severe exacerbation, only about half of them are still alive within three and a half years,” she pointed out. As for tozorakimab specifically, Barr christened the molecule “an AstraZeneca science success story,” harkening several years back to the point at which researchers began to explore IL-33 as a driver of respiratory disease, and COPD in particular. At the same time, “there was still so much that wasn’t understood,” she admitted, highlighting the insight that IL-33 signals through both ST2 and EGFR through the RAGE pathway, a discovery Barr attributed to AstraZeneca's own scientists. Understanding the need to tackle both pathways in COPD—and aware of competitor candidates in the hopper, including one that bound ST2—the company ultimately had to make some “courageous decisions,” Barr said. These included taking a prior COPD molecule offline and going back to the drawing board to reinvent its potential IL-33 label “to make sure that we had a molecule that could block signaling through both arms of the pathway, through both the reduced form and the oxidized form, knowing that we wouldn’t be first, but striving to be best.” “When we put [tozorakimab] into the clinic, we firmly believed that we had a differentiated molecule, and we saw the other molecules blocking just ST2 or partially blocking IL-33, unable to deliver two positive pivotal studies in COPD,” Barr explained. “We kept marching forward because we believed our molecule was differentiated, and now I think we have the clinical validation that supports that.” Ultimately, AstraZeneca finds itself on much better footing these days when it comes to potential biologic rivals to tozorakimab in COPD. Sanofi and Regeneron’s Dupixent, for instance, is approved to treat COPD exacerbations in patients with high eosinophil counts, but not low ones. Meanwhile, the future has become cloudier for other next-gen IL-33 candidates from Sanofi and Regeneron, as well as Roche, which have suffered trial flops in recent years. One other potential ingredient for AstraZeneca’s success in its duo of studies was that the company was “ambitious in the trial design, willing to look at an all-comers population,” Barr said, “and willing to enroll the most severe patients.” Prior studies for would-be biologics rivals in COPD “avoided enrolling” those patients, she pointed out. She also highlighted the Big Pharma’s painstaking design of exacerbations in its trial, which “gave us a very rigorous readout,” and pointed to “the extra effort and investment” the company put in to understand the effect of mucus plugs in patients. Barr described mucus production as a “key feature in disease diversity,” noting that mucus plugs—obstructing clumps of mucus that block patients’ airways—are associated with worse outcomes in COPD. In its data announcement, AstraZeneca noted that an integrated analysis of Oberon and Titania found tozorakimab “demonstrated a reduction in patients’ mucus plug score,” with the pharma claiming its biologic is the first to deliver such results in a broad COPD population. “So being able to reduce those mucus plugs, we expect, is an important part of driving benefit for patients who are living with COPD,” Barr said. Again touching on the breadth of the study populations, Barr added that tozorakimab “worked across all eosinophil levels in both current and former smokers across all levels of lung function,” which she suggested “really simplifies decision-making for clinicians, and it allows them to offer therapy to the broadest possible patient population.” In the highest patient eosinophil count group, tozorakimab helped chart a 43% reduction in exacerbation risk, which Barr stressed were “unprecedented data.” In the mid-level group, AZ’s drug delivered a 23% reduction and, in the lowest group, a 34% reduction in eosinophils, which Barr said suggests efficacy “in all patient subgroups.” As for AZ’s recent guidance upgrade on the medicine’s sales opportunity, the lift from a $3 billion to $5 billion range to $5 billion plus was informed by multiple factors, Barr said, including the fact that “in 2024, there were multiple competitors, and there aren’t anymore.” Additionally, “we know that this is a massive unmet medical need, and this is a really incredible set of data that we think will be very convincing to the clinical community,” Barr said. Looking ahead to a potential evolution of the COPD treatment landscape, Barr noted that most patients start treatment in the community with an option like a triple therapy, and for them, having an option like AstraZeneca’s inhaler Breztri will remain a “really important part” of that journey. But of the patients uncontrolled on triple therapy, which Barr described as “about half of them today,” just a “small fraction” are currently eligible for biologic therapy, which she emphasized AstraZeneca is working to change. Understanding that COPD is not a “one-size-fits-all” disease, AstraZeneca is also looking at its antibody drug Tezspire for patients with T2-driven disease, and the company continues to think about new mechanisms for tackling COPD through both systemic and inhaled drugs, Barr said.
New York Yankees' Aaron Judge Reports are Conflicting
How exactly will the New York Yankees integrate Aaron Judge back into the lineup?
Arkansas receivers did not impress, face a steep climb
The QB and the O-line are problems for Arkansas, but the receivers are, too
988 Day: What to know about Oklahoma's mental health lifeline
On 988 Day, a crisis services expert explains what happens when you call, text or chat with the 988 Mental Health Lifeline and why you don't have to be in immediate crisis to reach out.
Writer shares key fantasy piece regarding Quinshon Judkins
Quinshon Judkins is going to be a factor in fantasy lineups in 2026.
Online cybersecurity clinic available for Hawaiʻi small businesses
“The One-Person Security Department: Building Your Own Tools for Hawaiʻi IT on No Budget” is the topic for the first in a series of three free Zoom meetings presented by the University of Hawaiʻi Maui College for sole proprietors and registered businesses in Hawaiʻi.
TV Tinsel: Remembering the truly iconic Dolly Parton
If there’s one word overused in the English language, it’s “icon.” It seems that everything and everybody is an icon, diluting the reference by its casual use. But there is
Star Stable Entertainment reduces workforce by 20% to secure long-term future of its multiplayer horse adventure RPG
Interim CEO says by "reducing operating costs and refocusing resources," Star Stable will be in the "best possible position to adapt and grow"
Texas Sunset Review offers chance to address the mental health crisis-to-prison pipeline
Updates in policy for people with developmental disabilities and serious mental illness could reduce repeated cycling through the carceral system, advocates say
Battle of 224 headlines Friday’s Game of the Week
Around here, the Battle for 224 is one of the greatest rivalry games on the calendar - Poland versus Canfield.
Explainer: Why Air India's funding call has come under political scrutiny in Singapore
Air India's request for about $1.5 billion in funds from its owners — Tata Sons and Singapore Airlines — has sparked a debate in Singapore over state investor Temasek's exposure to the Indian carrier.
Academy Sports + Outdoors Announces Participation in Upcoming Investor Conference
Academy Sports + Outdoors (the "Company") (Nasdaq: ASO), a leading full-line sporting goods and outdoor recreation retailer, today announced its participation in the upcoming Goldman Sachs 33rd Annual Global Retailing Conference to be held Monday, September 14 to Tuesday, September 15, 2026. Chief Executive Officer, Steve Lawrence, and Chief Financial Officer, Carl Ford, will participate in a fireside chat that will be webcast live on September 15th, at 11:30 a.m. Eastern Time. The live webcast
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Six decades of politics (but little government)
The first aired episode of “Star Trek,” entitled “The Man Trap,” premiered on September 8, 1966 — 60 years ago today. I’m actually editing a political science fiction issue of The Forum right now, and it’s prompted to me think a lot about the ways that Trek deals with politics and government and what it’s offered us as commentary. The @smotus report is a reader-supported publication. To support this work, please become a paid subscriber. Subscribe The original TV series ran from 1966 to 1969. It had a loyal but modest following, but the audience grew substantially with the series in syndication for years after that. The franchise developed its first motion picture in 1979, followed by five sequels, and then a whole other series of films built around the “Next Generation” series that first aired in 1987. In recent decades, several more TV series have built up around it, including the current “Strange New Worlds,” now in its fourth season. Throughout the past six decades, the franchise has offered us a good many insights into US politics and international relations, although often disguised as science fiction yarns. The original series was largely a Cold War fable, with the United Federation of Planets (a stand-in for the US) perpetually at odds with the Klingon Empire (a stand-in for the USSR). The “Let That Be Your Last Battlefield” episode (1969) posited a planet divided into two races, largely indistinguishable to outsiders, but nonetheless constituting a brutal racial hierarchy. “Patterns of Force” (1968) showed a struggling planet where the leader had attempted to construct a benevolent dictatorship — literally Nazism without bigotry — and found that authoritarianism could not exist apart from hierarchy and oppression. (Relatedly, I’d put “Star Trek VI: The Undiscovered Country,” high on a list of dad films about the end of the Cold War, near “The Hunt for Red October.”) Get 20% off for 1 year Indeed, the original series itself was something of a political statement, with a multi-racial crew running the Enterprise, a diverse and largely peaceful Federation mostly free from want and oppression, and protected by Starfleet, an armed force whose scientific mission was at least as important as its military one. Famously, when Nichelle Nichols wanted to walk away from the role of Uhura on the original series, none other than Martin Luther King, Jr. met with her and urged her to remain on the show, discussing the importance of viewers seeing an intelligent Black woman as part of the command team three centuries hence. Later series in the Trek franchise offered a good deal of political commentary on their own, but probably none as explicitly and incisively as “Deep Space Nine,” which ran from 1993 to 1999. The episodes surrounding the Dominion War, especially the “In The Pale Moonlight” (1998), showed the compromises, sacrifices, and moral rot associated with winning even a just war — probably better than any series would until “Andor” (2022-25). In “Far Beyond The Stars” (1998), Captain Benjamin Sisko is somehow transplanted to the role of a science fiction writer in 1950s New York. The writer is frequently sidelined and his ideas stolen because publishers don’t want to credit a Black writer. Several series have depicted the secretive Section 31 — an unacknowledged black ops security force operating within Starfleet. These episodes often end up using Section 31 as a foil to show the dangers of a lawless group within a lawful society, even (especially) when that group posits itself as essential for everyone else’s freedom to continue. The current “Strange New Worlds” has played with a few political themes. I found the first two seasons of this show among the best that the Trek franchise has produced in decades, but this season and the last have really been struggling for ideas. Yet one interesting thread is the idea that the diplomatic and enlightened leadership style of Captain Christopher Pike will not work in all situations. “A Quality of Mercy” (2022), which I wrote about here, puts Pike in the middle of a battle with a Romulan vessel in an alternate timeline, and finds that Pike’s conciliatory style would actually make a lengthy and deadly war more likely, while a quick and more violent approach might have prevented the war. This season’s opener, “Valles Marineris,” shows a pre-lightspeed civilization locked in a war to the death with a neighboring planet. The idea of an alliance or a federation hasn’t even occurred to them — their ship’s commander is curious but doesn’t see it as an option. For a franchise as political as “Star Trek,” one thing we almost never see is the government. We get occasional glimpses of Starfleet’s council — mostly uniformed people at a rectangular table — but almost no sense of how the Federation is governed. Are there elections? Who is in the legislature? How much power does the president have? What kind of factional divisions do they wrestle with and how? The shows and films are pretty silent on this. We’ve seen a few military tribunals within Starfleet, but little about how civilians deal with crime and injustice. With recent years seeing some of the franchise’s more interesting plot lines and casts, it seems clear that Star Trek is still full of energy and ideas. Given the erosion of American democracy and the reshuffling of the international order, there’s no shortage of material for future shows to comment on. I’m not sure we should toast to 60 more years, but cheers to a show that continues to teach us about ourselves. Share
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