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CDC dilemma: Nominee may need both MAHA and science chops
As a deadline arrives this week to nominate a Centers for Disease Control and Prevention director, some Republicans are skeptical the administration will find someone who can check all the boxes necessary for confirmation. The candidate will need the “Make America Healthy Again” mindset of Secretary Robert F. Kennedy Jr.’s Health and Human Services Department, […]
Mr. Tire employee arrested for twice setting fires at the business: Solon Police Blotter
Also in this week's blotter, the driver of a Jeep SUV would not stop for Solon police, who were attempting to cite him for an expired license plate.
Entertainment and more in the Mid-Ohio Valley
PARKERSBURG – The Artsbridge calendar for this week: TODAY * Geppetto Woodcarver’s Wood Quilt display, 9 a.m. to 4 p.m., WesBanco, Market Street, Parkersburg * Art is Life/Life is Art, ages 55-plus,10:30 a.m. to 12:30 p.m., Parkersburg Art Center * Butterfly Photo Holder, ages 13-plus,11 a.m. to noon, Marietta Public Library * Hygge Club, adults, […]
The Monday Outlook: Project Hail Mary and the Science Behind Blockbuster Sci-Fi
Project Hail Mary is the latest sci-fi blockbuster to stretch the bounds of audience imagination and stir the curiosity of real scientists. But the science driving films like Project Hail Mary, Interstellar and The Martian isn’t all fictional: at UChicago, researchers exploring the cosmos and decoding the origins of life are making discoveries that would feel right at home on the big screen. This week's Monday Outlook features scientists from UChicago and Argonne National Laborat
Seattle Sports This Week: TV and radio for March 23-29
A look at the broadcast schedule for March 16-22 on Seattle Sports 710 AM and the Seattle Sports app, as well as local sports teams on TV.
Trump Poised to Skip CPAC For First Time in a Decade
President Donald Trump is poised to skip the Conservative Political Action Conference this week, breaking with an annual tradition that has helped define his political rise and shaped the conservative movement.
New C8 Corvette Grand Sport Makes Surprise Debut at 12 Hours of Sebring
The first mid-engined Grand Sport dons a widebody and red hashmarks, with the car's full reveal coming later this week.
Microsoft announces Xbox Partner Preview for this week, with Ryu Ga Gotoku's Stranger Than Heaven finally making a showing
Microsoft has announced its next Xbox Partner Preview showcase will take place later this week, focused on third-party games from the likes of Sega and GSC.
Happening this week | Women Working and Winning in Politics Roundtable
The 3rd annual Women Working & Winning in Politics Roundtable will be held at Dillard University
David Gallo opens up about why AI data centers, private equity are good for his company
After Katrina, David Gallo led his family's company, Gallo Mechanical, through a geographic expansion that helped grow the company to nearly $500 million in revenues and more than 700 employees. Last year, he led the 80-year-old business through a sale to a private equity firm. In this week's Talking Business, he explains why it was a good thing
What events are happening in the South Bend area from March 23 to 29?
A variety of events will keep you busy this week. Attend a screening event, catch a concert, attend a lecture or play.
US soccer legend Landon Donovan opens up on mental health struggles, redefining success
American soccer legend Landon Donovan opened up about mental health struggles and reconfiguring what success meant to him. He releases "Landon: A Memoir" this week.
'Project Hail Mary' blasts off to record-breaking $80 million, becomes 2026's best premiere
'Project Hail Mary' burned through the outer layer of box office projections this weekend, reaching an astounding $80 million in its domestic premiere and $141 million worldwide.
Your Thymus and Your Healthspan
Our thymus gland plays a central role in the development or our immune system, specifically for supporting T cell development (how these cells got their name, maturation and differentiation in the thymus) and discriminating between self and foreign, non-self antigen proteins with production of dendritic cells. As we age, our thymus gland shrinks—the process known as involution—with progressive change from spongy to fatty tissue, with loss of functionality. But this process, with respect to timeline and extent, markedly varies from one person to the next. And to make things even more complicated, our thymus gland anatomy and precise location in the chest also is highly variable. So the famous Frank Netter diagrams from the 1960s (such as at left below) don’t capture the remarkable heterogeneity that a random set of 12 chest CT scans (below at right). What I consider as 2 landmark papers in Nature this week (here and here) used AI to quantify health of the thymus in 2 large cohorts, and then correlate the metric to a broad array of health outcomes. In this edition of Ground Truths, I’m going to cover three questions: (1) How was thymus health determined by AI?; (2) How is thymus health linked to key clinical outcomes? and (3) Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? Subscribe 1. How was thymus health determined by AI? This was accomplished by extensive work developing and validating an AI pipeline for 2 stages, the first for localization and segmentation of the thymus bed, and the second to quantify a digital marker, termed the thymic health score. There’s a lot to this algorithmic development, so I won’t go into all the details, but just provide a rudimentary outline of what was done. The 1st stage used supervised learning with 2 radiologists reviewing 2,461 chest CT scans. That work trained a 3D U-Net model to automatically identify the thymic bed’s 3D cropped region using center of mass coordinates, which reached 99.8% accuracy. The 2nd stage used a foundation model that was pre-trained with SwAV (which stands for Swapping Assignment between multiple Views), a self-supervised model, that generated a high-dimensional thymus representation of 4,096 features. That compares to the radiology reductionist and subjective scoring of 0 to 3 where 0 means the thymus is fully degenerated and fatty, and 3 is considered dense, intact glandular soft tissue. Notably, the self-supervised learning (SSL) performance was superior to supervised (AUC ~0.75 vs 0.55, respectively) reflecting the shallowness of the 0-3 classifier vs SSL’s holistic, self-taught AI. The thymic health score ranged from 0 to 100, with the highest number indexed to fully preserved thymic health. The algorithmic work extended to explainability with both Shapely value distribution, meaning the model was holistic not relying on any “magic” pixel, and occlusion sensitivity, demonstrating the model’s performance was not affected by ribs, sternum, lung tissue, but rather focused on the thymic bed directly. Below are a few saliency maps from the occlusion sensitivity that indicate the thymic bed focus, not affected by neighboring structures, using the jet color scale. Now the AI was ready for processing ~25,000 CT scans, each over 30 MB files, from the 2 large participant cohorts to provide a thymic health score, it did so in less than 14 hours, which is less than 2 seconds per scan! Share 2. How is thymus health linked to key clinical outcomes? The two cohorts were the National Lung Screening Trial, NLST (N=25,031) and the Framingham Heart Study, FHS (N=2,581) each with baseline demographics and long term follow up of >12 years for health outcomes. From the NSLT, you can see below that increased age and body-mass index were correlated to reduced thymic health. And, overall, men had reduced thymic health scores compared with women. There are a lot of graphs in the paper for outcomes, for both the NLST and FHS cohorts. To simplify the major outcomes, below is a composite Figure with striking reduction of all-cause mortality and for the different causes of death. The results were consistent between the 2 cohorts. For example, the cardiovascular mortality hazard ratio average was 0.57 in NLST and 0.38 in FHS (weighted to be 0.53 for the aggregate). The reduction of mortality also extended to digestive diseases and pulmonary disease (data not shown below). Lung cancer incidence was reduced by 36% for high vs low thymic health (Figure below, with a panel -incidence and b panel-mortality, adjusted for age, sex, BMI, smoking status). Notably, there was a smoker’s paradox: lower incidence and improved survival for lung cancer in smokers who had a high thymus health score. Smoking was associated with lower thymic scores whereas alcohol was not. Higher thymic health was linked to higher HDL cholesterol, lower triglycerides, lower fasting blood glucose, and lower systolic and diastolic blood pressure. Inflammation biomarkers, such as C-reactive protein and interleukin-6, were elevated in the people with lower thymic health scores. In their second paper, the same team looked at the relationship between thymic score and outcomes for 3,476 patients receiving cancer immunotherapy. The non-small cell lung cancer progression-free survival was reduced in patients with low thymic health score. A parallel relationship for survival was seen for other types of cancer including melanoma, breast, and kidney with a 44% lower risk among high thymic scores (Figure). A similar pattern was seen with different immune checkpoint inhibitors. The thymus health score outperformed programmed death ligand-1 (PD-L1)and tumor mutation burden (TMB) assay of the tumor and was an independent prognostic marker of progression-free survival. In this dataset, a direct connect with thymus score and adaptive immune function was noted with a correlation before cancer treatment for both T-cell diversity and thymus T-cell production (a metric known as T cell receptor excision circles). Thymus Removal Study There is a highly relevant citation about thymus function before moving onto ways to rejuvenate it. In 2023, a very important study of thymus removal during cardiothoracic surgery was published, with 1146 patients undergoing thymus removal vs 1146 matched controls (mean age 55 years). The adverse outcomes for thymus removal were striking, with a 2.9 higher risk of all-cause mortality and doubling of cancer incidence, 1.5 fold increase in cancer mortality, and 1.5-fold increase in autoimmune diseases. The immune function showed marked compromise after thymus removal, as reflected by CD4+ and CD8+ T cells (Figure below) Share Ground Truths 3. Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? In recent months we’ve learned a lot about the process of thymus involution and the pathways by which this may be modulated. Thymus involution is primarily due to loss to thymus epithelial cells (TECs) and there are 2 subtypes with different functions: the cortical, responsible for positive selection of T cells, and the medullary, for negative selection. When adipose tissue infiltrates the thymus, thymic adipocytes are pro-inflammatory, knocking out T-cell output. Likewise, systemic inflammation, or “inflammaging,” from smoking, obesity, and chronic stress promote thymic adipocytes. Now, from preclinical studies, we know about key pathways that account for these processes. Historically, back in 2014, FOXN1 was recognized as a single master transcription factor essential for TEC function, with studies in mice with forced FOXN1 upregulation leading to thymus regeneration. That laid the foundation for potential regrowth of quiescent thymus cells. It took awhile to find pathways to accomplish this goal and to even refute its role as the master regulator. The Liver-Thymus Axis Feng Zhang and his team recently showed that injection of an mRNA vaccine to the liver encoding DLL1, IL-7 and FLT3-L in combination, factors known to support thymopoiesis (Figure), successfully enhanced immune function in aged mice. However, the effect was transient. The FGF21 Story Two reports in 2025 addressed the thymus gland’s production of FGF21, a growth factor (fibroblast growth factor 21) and its control of thymus involution. This growth factor is also produced by the liver, but it doesn’t have impact on the thymus in aged rodent models. In contrast, The liver’s hepatocyte growth factor (HGF) has been shown to reverse senescent TEC structural changes. Growth hormone stimulates production of insulin growth factor-1 (IGF-1) in the liver and the thymus. Two small studies in human participants (TRIIM, for Thymus Regeneration, Immunorestoration, and Insulin Mitigation) of 6 and 50 people, respectively, treated with combined human growth hormone, metformin and DHEA, suggested the potential of slowing epigenetic aging and improving thymus mass and function. But the combination of drugs, small sample, and lack of controls make conclusions murky. Increased thymus FGF21 led to increased CD8 T cells in old mice and extended healthspan and improved physical performance. Building on the previous FOXN1 data, ablation of β-klotho, the obligatory co-receptor for FOXN1, accelerated thymic aging. The benefit to FGF21 was confirmed in a companion paper using an FGF21 knock-in mouse model showing thymus enlargement and increased TECs throughout the lifespan. (schematic Figure below). The accompanying editorial for these 2 papers speculated: “The proposed link between age-associated thymus involution and organismal aging is intriguing, and suggests we might seek to achieve systemic rejuvenation by counteracting thymic involution.” Other Factors Lessons from the Axolotl (Mexican Salamander) In an elegant set of experiments of the axolotl (Figure), known for its complete thymus regeneration after total surgical removal, mediators were identified. Surprisingly FOXN1 was dispensable. But midkine, a growth factor, appeared to be the driver, the initiator of thymus cell growth, survival, and repair. Other components that contributed were Postn+ (periostin-expressing mesenchymal niches) and Ccl19, a chemokine protein from the bloodstream. RANK and RANKL RANK (receptor activator of nuclear factor κB its ligand (RANKL) have been considered key regulators of medullary TECs. In a study of both aged mice and human thymus cell cultures, their key role was confirmed, with multiple benefits of resorting TEC function, recruitment of progenitor cells, and T cell development. Subscribe Summing Up This body of work strongly supports the health of the thymus gland as a critical regulator of human healthspan, not just a correlate or link. The new landmark studies are reinforced by the regenerative biology experimental models that have shown, via an array of mediators, that healthspan of aged mice is at least in part dependent on thymus gland function and its critical role for maintaining adaptive immunity. It sure seems that we’d be better off having an immune reservoir of naive T cells instead of a profile in older adults of exhausted, low quality, memory T cells, with a senescent phenotype. It is striking that we ignored the importance of the thymus gland for many decades. A wake-up call was the results of the thymectomy matched control study reviewed here, with the opposite of high thymic health score improved health outcomes. The convergence of AI and healthspan here is notable. The exceptional and laborious work for developing and validating (no less explaining) the AI to quantify thymus health set the foundation for probing the connect the major health outcomes in two cohorts with extensive follow-up. We’ve never had a way to meaningfully quantify the thymus gland before, so this represents important leverage of supervised, self-supervised, and transformer models. The study wouldn’t have been possible without AI. And it begs the question as to whether there are ways we can maintain our thymus at a high health score. But it’s not so simple to rejuvenate our thymus. There are multiple risks including the induction of autoimmunity, increasing the risk of cancer, and inducing a pro-inflammatory state. For example, factors that increase TEC proliferation could compromise the medulllary negative selection process and leak out auto-reactive (self-attacking) T cells. Thymic cells could be induced to proliferate, but we know, for example, that growth hormone and IGF-1 are associated with an increase risk of cancer. If thymus rejuvenation doesn’t clear out the accumulated senescent cells in older adults, then inflammation within the gland could block the production of TECs. Keeping these risks in mind, we now have identified many ways to keep our thymus healthy as we age that undoubtedly will be tested in clinical trials going forward. Ultimately, the benefit-to-risk tradeoffs will be defined. In the meantime, we have desperately needed an immunome. As I’ve stressed in multiple prior Ground Truths, we have no test in the clinic to assess a patient’s immune status! It was very encouraging for me to get an email from Hugo Aerts, the senior author of the landmark papers in the days after they were published: “I also wanted to say that your Substack on “Why We Need an Immunome” was inspiring for this work. We found it a very compelling perspective and greatly enjoyed reading it.” Just having an assessment of a person’s immune status via a chest CT scan, with millions of these performed per year, might help in guiding the right immunotherapy for cancer (e.g. more intensive, combinations for those with low thymic health scores) and help define people who are increased risk for age-related diseases of cancer, cardiovascular, and neurodegenerative. The main theme of Super Agers is that we now have many layers of data (genetics, proteins, biomarkers, organ clocks that can be integrated via multimodal AI) for us to define a person’s specific risk decades before one of these age-related diseases leads to symptoms, enabling prevention. From the new studies this week, we can add thymus health score as yet another way to understand a person’s risk, a window into their adaptive immune system and healthspan. And perhaps someday we will be able to safely rejuvenate the thymus, or maintain its health through one’s life, and use the thymus health score to monitor. NB: I wrote this post (No A.I.) A Quick Poll Loading... ********************************************************************* Thanks to Ground Truths subscribers (now > 200,000) from every US state and 212 countries. Your subscription to these free essays and podcasts makes my work in putting them together worthwhile. Please join! If you found this interesting PLEASE share it! Share Ground Truths Paid subscriptions are voluntary and all proceeds from them go to support Scripps Research. They do allow for posting comments and questions, which I do my best to respond to. Please don’t hesitate to post comments and give me feedback. Let me know topics that you would like to see covered. Leave a comment Many thanks to those who have contributed—they have greatly helped fund our summer internship programs for the past two years. It enabled us to accept and support 47 summer interns in 2025! We aim to accept even more of the several thousand who will apply for summer 2026.
Politics Now: March 22, 2026
This week on Politics Now with host John Langeler: Nevada is trying to lessen its reliance on fuel from California. We talk with the vice-chair of the committee tasked with determining how to do th…
Apple’s busy March continues with three notable arrivals this week
Apple has had a jam-packed March so far after launching seven new products and surprisingly announcing an eighth. Looking ahead,...
Science Central: Planetarium opens this week
Wednesday at 10:30 there will be a ribbon cutting unveiling the 1,830-square-foot planetarium features a 21-foot-high, 28-foot-wide dome.
Things to do in Cincinnati this week, March 23-29
If you're looking for the best events happening in Cincinnati, you're at the right place. Find your next concert, game, festival or family event.
Buffalo Museum of Science hosts DinoFEST this weekend
BUFFALO, N.Y. (WIVB) — The Buffalo Museum of Science got a little prehistoric Saturday. This weekend is DinoFEST where the museum educates visitors about paleontology, geology, and offers hands on …
Politics Unplugged (Full Episode) March 22, 2026
This week on Politics Unplugged, Progressive activist Kai Newkirk explains why he is running to unseat Democratic incumbent Greg Stanton in the congressional race in CD4. Then, consultants Marcus Dell’Artino and Matt Grodsky discuss the fallout from the Cesar Chavez allegations and the political importance of high gas prices.
DNA building blocks on asteroid Ryugu, bacteria that eat plastic waste, and more science news
Catch up on some of the most interesting science stories from this week.
Science news this week: Super El Niño looms, an Acropolis marble fragment resurfaces, and a pure hexagonal diamond is born
March 21, 2026: Our weekly roundup of the latest science in the news, as well as a few fascinating articles to keep you entertained over the weekend.
Possible Habitability On Mars Pushed Back Millions Of Years, The Forgotten Apocalypse: Scientists Think Earth's First Mass Extinction Has Been Hidden In Plain Sight, And Much More This Week
All the biggest science news stories of the week.
Denver Broncos mock draft: Post-Jaylen Waddle trade
We’re coming back to the mock draft simulator this weekend. The Denver Broncos said ‘f dem picks’ and acquired wide receiver Jaylen Waddle from the Miami Dolphins this week. That trade provided a big boost to the offense, but it will make their 2026 NFL Draft much more challenging. With the reduction in draft capital, […]
The Price of Oil Is Surging. Here’s How It Could Get Much Worse.
Slate’s guide to the most important figures in politics this week.
Battling for top-six spot, Sixers face youth-driven Jazz
Earlier this week, Joel Embiid was said to be close to a return from a right oblique strain.
Business owners meet with Nashville mayor over high property taxes
Nashville business owners met with the mayor this week after he said will "figure something out" for property tax relief.
Quiz: This week in politics
It was another busy week in national politics. Take this quiz to see what you know and what you missed.
Why Tencent Music Entertainment Plunged Almost 30% This Week
The Chinese music streaming leader posted decelerating subscription revenue and said it would no longer disclose certain metrics going forward.
The MacRumors Show: Surprise AirPods Max 2 Announcement
On this week's episode of The MacRumors Show, we discuss Apple's surprise announcement of the AirPods Max 2 this week. Subscribe to The MacRumors Show YouTube channel for more videos The AirPods Max 2 introduce a range of improvements primarily driven by the addition of Apple's H2 chip, which replaces the H1 chip used in previous models.
Music Industry Jobs: The Core Entertainment, Republic Records, CAA
Music industry hires and promotions this week include job appointments at The Core Entertainment, MCA, Republic Records, CAA and AudioSalad.
Unilever Has $40 Billion in Tasty M&A Options
Options have value. And it’s become clear this week that Fernando Fernandez has more than one when it comes to setting a new course for Unilever Plc’s food business, owner of Hellmann’s mayo and Knorr stock cubes. How the consumer giant’s still relatively new chief executive officer plays his hand will likely define his tenure.
Player availability report, presented by Orlando Health Orlando Health Jewett Orthopedic Institute: Orlando Pride vs Denver Summit
Here is this week's player availability report, presented by Orlando Health Jewett Orthopedic Institute, for Friday's home match vs Denver Summit
Whole Hog Politics: The political establishment thrives in our broken primary system
[Watch Whole Hog Politics live: Join us today at 9 a.m. EDT at TheHill.com as Chris Stirewalt and host Bill Sammon break down this week’s political news and answer questions from a live online audi…
The nation’s cartoonists on the week in politics
Every week political cartoonists throughout the country and across the political spectrum apply their ink-stained skills to capture the foibles, memes, hypocrisies and other head-slapping events in the world of politics. The fruits of these labors are hundreds of cartoons that entertain and enrage readers of all political stripes. Here's an offering of the best of this week's crop, picked fresh off the Toonosphere. Edited by Matt Wuerker.
MYB This Weekend: Koufos Talks Navigating Business Challenges Through Cottage Four
On this weekend’s “Minding Your Business” on News 12+, Cottage Four President John Koufos talks with Bob Considine about his leading consultancy and
HOMETOWN ENTERTAINMENT: Weekend events across Southwest and Central Virginia
Concerts, a 5K and free family events are planned across the region this weekend
New dispute emerges around Subnautica 2’s early access release
Lawyers for the ousted—and now partially reinstated—leadership team of Unknown Worlds, the studio behind Subnautica 2, are crying foul over news that the game will be released into early access in May. The release announcement earlier this week was made improperly, potentially “damaging the game and sowing additional confusion among the Subnautica community,” the lawyers said in a letter sent on Tuesday to Vice Chancellor Lori Will of Delaware’s Court of Chancery. In their letter, the lawyers also floated the idea of asking Will to find Krafton in contempt of the court’s ruling. The letter was sent just one day after Will’s bombshell ruling that publisher Krafton had breached its contract with Unknown Worlds’ executive team, when it fired them last June. The new issue isn’t necessarily the May early access timeframe, but how the news was announced. The letter and Krafton’s response have not been previously reported. A quick recap of prior events: Subnautica 2 is an unreleased, underwater survival adventure and the most-wishlisted game on Steam. Last year, longtime Unknown Worlds CEO Ted Gill, along with studio co-founders Charlie Cleveland and Max McGuire, were fired by Krafton. They swiftly sued, saying the publisher had terminated them to avoid paying out up to $250 million in potential performance-based bonuses. The studio leaders had hoped to earn that with an early access release of the game, which Krafton had blocked. The publisher argued in court that Subnautica 2 wasn’t ready, which the ousted execs disputed. On Monday, Will ruled that Krafton had violated its contract, firing the execs to avoid the performance payouts, and that it had to reinstate Gill and give him full authority over any early access release for Subnautica 2. On Tuesday, IGN reported on a new memo issued that day to Unknown Worlds staff by Steve Papoutsis, the executive Krafton had put in charge of Unknown Worlds after the 2025 firings. In the note, Papoutsis said that Subnautica 2 had passed a key development milestone “last week” and that he and Krafton had determined the game “is ready for Early Access release in May.” This news appeared to catch the lawyers for Gill, Cleveland and McGuire by surprise. On Tuesday night, they sent a letter to Will expressing “serious concerns” about whether it would be possible to forge an agreement with Krafton consistent with the judge’s order. Papoutsis’ memo was a problem, they wrote. He didn’t have the authority to declare anything about Subnautica 2’s release. As of 9am ET on Monday, March 16, the effective date of Will’s order, Papoutsis wasn’t CEO of Unknown Worlds. Gill was. And, per Will’s order, only Gill could make Subnautica 2 release decisions. They continued: Krafton self-servingly announced the launch without any regard to its impact on the game, the team, or the community—let alone this Court’s Opinion. Announcing the release of a game is momentous, and it is typically accompanied by significant marketing activity, fanfare, and community coordination. And most importantly, the announcement is carefully designed to maximize excitement for the game. That entire process was supposed to be driven by Mr. Gill. However, in defiance of the Court’s Opinion, Krafton has now taken that away, further damaging the game and sowing additional confusion among the Subnautica community. The lawyers speculated that Krafton had “intentionally leaked” Papoutsis’ memo and then issued an official statement to confirm the leak. Game File is a reader-supported publication. My reporting is only possible through support from readers like you. To support my work, consider becoming a free or paid subscriber. Subscribe On Wednesday, lawyers for Krafton defended their client in their own letter to vice chancellor Will, saying nothing they did violated her order nor showed contempt: Papoutsis’s message was simply celebrating the UW employees’ efforts toward a past event: Krafton’s pre-Opinion determination that Subnautica 2 was ready for Early Access release. There was nothing improper about conveying the results of the milestone review or thanking the development team for their dedication and talent. They added that Gill could still make his own call about Subnautica 2’s release: In his role as CEO, Gill will be able to assess independently his views on the state of Subnautica 2 and the appropriate release schedule; nothing in Papoutsis’s message alters Gill’s authority or discretion. Vice chancellor Will has not responded to the letters and doesn’t necessarily have to. Both parties were previously ordered by Will to confer this week and submit a proposed judgment consistent with her ruling. The letter from Gill’s attorney’s this week doesn’t indicate whether he would or would not support a May release for Subnautica 2. But it could limit his options. And, if Gill’s lawyers are right, the lack of marketing fanfare around the leak of the May date could dull the launch of the game. Any harm to Subnautica 2’s launch is an extra sensitive issue given the context of the legal dispute: millions of dollars of payouts are on the line, tethered to the scale of the game’s initial performance. In her ruling on Monday, Will noted that there was obvious “bad blood” between Gill’s side and Krafton but that the two would need to work together: “They can—and must—act in good faith to navigate their remaining contractual relationship.” Item 2: A new kind of couch co-op game A highlight of GDC each year is the Alt.Ctrl showcase that features games played with extremely experimental controllers. Perusing this year’s offerings last Friday, I found a game controlled with giant scissors, another with big toothbrushes and one that amounted to dumpster diving. My favorite was Pivot, a co-op game about collectively maneuvering a couch. It was developed by students at the University of Utah’s masters of arts and engineering games program. Players lift and tilt the physical couch in order to control the position of a virtual one. That virtual one is moving through an obstacle course on-screen, while being pursued by a giant skull. Developer Nishant Verma told me at GDC that the couch is made of styrofoam (this became more evident as I watched!) and that the name was a riff on an episode of the sitcom Friends. Item 3: In brief… 🚫 Ubisoft is laying off more than 100 workers at its Red Storm studio, as the North Carolina location known for decades for its Tom Clancy games, ceases in-house game development, VGC reports. 👀 On Monday, Nvidia’s revealed its DLSS 5 AI-driven graphics technology that purports to improve game graphics… and it has been roasted about it by the media and the online gaming public for the remainder of the week. The tech changed the faces of characters in footage from Resident Evil Requiem, Hogwarts Legacy and EA Sports FC, drawing accusations of giving carefully art-directed games the generic look of AI “slop.” Nvidia CEO Jensen Huang had said on Monday that “DLSS 5 is the GPT moment for graphics—blending handcrafted rendering with generative AI to deliver a dramatic leap in visual realism while preserving the control artists need for creative expression.” By mid-week, Huang was telling Tom’s Hardware that the new tech’s critics were “completely wrong” because game-makers could still “fine-tune the generative AI” to suit their game’s aesthetics.
Mortgage rates jump to highest level in nearly 4 months
The average rate on a 30-year fixed mortgage rose this week to 6.22%, according to the latest Freddie Mac data released Thursday. That is up from last week's reading of 6.11%.
The West Is Roasting
This week’s record-breaking heat dome augurs badly for the months to come.
Free Play Days – Sea of Thieves, Totally Reliable Delivery Service, Trailmakers, Hell Let Loose and Firefighting Simulator: Ignite
Free Play Days - hop into Sea of Thieves, Totally Reliable Delivery Service, Trailmakers, Hell Let Loose and Firefighting Simulator: Ignite this weekend.
What to watch this week in New Orleans theater: ‘Gatsby,’ ‘Streetcar,’ ‘Little Shop,’ more
Step into the Jazz Age with a lavish musical adaptation of F. Scott Fitzgerald's classic tale at the Saenger Theatre. Don't miss the chance to witness Jay Gatsby's larger-than-life story come alive on stage!
4 Takeaways from the Fanatics Flag Football Classic Draft
Tom Brady is eager to return to the field in the Fanatics Flag Football Classic this weekend. Here's what you need to know.
International Arctic delegation gets crash course on Fairbanks politics
More than 20 dignitaries are visiting the Fairbanks North Star Borough this week as part of an European Union-sponsored initiative to foster collaboration among Arctic nations.
Brady, NFL stars to test flag football skills vs. Team USA ahead of Olympics debut
Are NFL players better than flag football athletes at flag football? We could get the answer at the Fanatics Flag Football Classic this weekend.
'The Africans' lecture, Comedy for a Cause, flamenco performance and more events this week
Put these on your calendar ...
Entertainment this week: Once Upon A One More Time, DJ Bowie Jane and more!
Friday, March 20 Friday Night Music at Cottonwood Restaurant – 6:30-8:30 p.m., Cottonwood Restaurant & Bar, 10142 Rue Hilltop. Join us each Friday at Cottonwood Restaurant & Bar in Truckee for a fun night of...
This Week in Sports Trivia: March 19, 2026
How closely were you following the sports news this week? Find out and test your knowledge by taking The Athletic's weekly quiz.
Early Easter party, Red Beans & Rice Fest, and Buddy Walk: 3 things to do this weekend
Our 3 picks
NEED TO KNOW: Arts and culture news this week
What you need to know in arts and culture news this week.
How Japan’s Leader Sanae Takaichi Found Her Voice in D.C. Decades Ago
Prime Minister Sanae Takaichi got her start in politics as an intern for a trailblazing Colorado lawmaker. She returns to Washington this week to meet with President Trump.
One big question: how have increased energy costs affected your business?
For this week's One Big Question feature, we ask business leaders how increasing fuel and energy costs have been affecting their bottom lines.
2 Arizona resorts, Hawaiian BBQ spot cited by health inspectors
Two Arizona resorts and one Phoenix Hawaiian BBQ spot were among places cited by health code inspectors in this week's Dirty Dining report.
F.B.I. Investigates Joe Kent, Whose Resignation Over Iran War Angered Trump
Mr. Kent is under investigation for a possible intelligence leak, according to people familiar with the situation. The inquiry is said to predate his resignation this week as the top U.S. counterterrorism official.
HOMETOWN ENTERTAINMENT: Sheena Easton performing Saturday at Millwald Theatre in Wytheville
Sheena Easton brings over four decades of hits to Wytheville this weekend.
Champions League scores: Live updates as Barcelona face Newcastle, Liverpool, Tottenham Hotspur in action
All six English teams entered this week after going winless in the first leg, with only Arsenal booking a spot in the quarterfinals so far
EU Seeks to Ease Burden on Business in Investment Push
Europe’s competitiveness issues are returning to the forefront this week as EU leaders meet.
7 events in Lancaster County this weekend, from a plant shop reopening to Zenkaikon
Spring starts this Friday, and there are plenty of ways to celebrate its arrival through the arts scene in Lancaster County this week.
Nintendo Expands Switch 2's GameCube Library This Week
Pokémon XD: Gale Of Darkness is here
Spigen's New AirPods Pro 3 Case Is Modeled After the Original Macintosh Mouse
Accessory maker Spigen this week expanded its lineup of case options that are designed to look like vintage Apple Macs. The clever new Classic LS AirPods Pro 3 Case resembles a the iconic Apple Macintosh mouse, so it goes well with Spigen's Mac-style iPhone cases. Priced at $25 from Amazon, the case features the stone color that was used for the Classic Macintosh, along with a gray mouse button.
Space Needle, Pacific Science Center finalize $17M property purchase
This week, owners of the Space Needle closed on the $17.25 million purchase of 21% of Pacific Science Center's property.
Space Needle purchases part of Pacific Science Center for $17 million
This week, owners of the Space Needle closed on the $17.25 million purchase of 21% of Pacific Science Center's property.
House leaders tie business tax benefits to income tax ballot question
House budget writers tucked a provision in a bill advancing this week that would potentially block benefits worth up to $400 million a year if the ballot question passes in November.
This 2019 Bloody Horror Hit Is A Top Movie On Hulu Right Now
See what else is trending on streaming services this week.
Fishing shop says business is unusually good for March, but warm winter could hurt them down the road
With temperatures expected to push record highs for March later this week, typically summer-oriented businesses are experiencing an early-season boost in success. While things are looking good in t…
Hochul says she'll announce proposed changes to 2019 climate law this week
The CLCPA will likely be the key sticking point as state budget talks begin among the governor and the Democratic-led Legislature.
Republican in Congress resist calls for Iran war hearings, creating a new standoff with Democrats
Some Democrats are threatening this week to force a series of votes on the war, hoping that the efforts to gum up the Senate's voting schedule will prod Republicans to action.
Why Is Jenna Bush Hager Absent From ‘Today’ This Week?
Find out who will fill in for Bush Hager on the NBC morning show's fourth hour.
Free Health Screenings & Safety Demos Scheduled For Thursday
Emergency responders and health care providers are hosting a free community event this week for local residents.
I heart this media.
This weekend’s Saturday Night Live episode hosted by Harry Styles had multiple bangers and I’ve been really impressed by the writing team over the past couple seasons. But this latest bit on Weekend Update about the social status of emojis felt exceptional. I don’t want to spoil it, but… “RBF: right before the flags” is some of the smartest writing on the show in a long time. This skit took the aerial tramway directly to my own heart. [Media: https://www.youtube.com/watch?v=59CpJqCbxXs]
This Week in Politics with UC Santa Cruz Professor Nolan Higdon
UC Santa Cruz Professor Nolan Higdon talks about the conflict in Iran and more of the latest political news.
Black Twitter's Most Hilarious Tweets This Week
"Im helping my grandma do some paperwork and she talmbout is she a Veteran."
This Week in Missouri Politics - March 15, 2026
Missouri Times Editor Jake Kroesen is joined by State Senator Travis Fitzwater.
Asia-Pacific allies ink $57 billion in deals with US companies, Burgum says
Asia-Pacific allies agreed to $57 billion in 22 deals with American companies during this weekend's Indo-Pacific Energy Security Forum in Tokyo, U.S. Interior Secretary Doug Burgum said on Sunday.
Player availability report, presented by Orlando Health Orlando Health Jewett Orthopedic Institute: Orlando Pride vs Seattle Reign
Here is this week's player availability report, presented by Orlando Health Jewett Orthopedic Institute, for Sunday's home match vs Seattle Reign
This Week in Gaming (Week 12)
Welcome to week 12 and a jam cram packed week of rather big new releases. We kick off this week with a AAA release which is an open-world action-adventure that supposedly takes place in a desert, yet apparently not at all. This is followed by a very blocky looking RPG, several deadly sins, a cube of...
Things to do in Cincinnati this week, March 16-22
If you're looking for the best events happening in Cincinnati, you're at the right place. Find your next concert, game, festival or family event.
2026 Big 12 men's basketball tournament bracket, scores, results: Arizona tops Houston in Big 12 title game
A number of teams could provide a very real challenge to the Wildcats this weekend in the Big 12 tournament.
Examining MSU's plans in the NIL college sports era
This week we published an exclusive from columnist Graham Couch about MSU's plans for Spartan Ventures to boost athletics.
Politics Unplugged (Full Episode) March 15, 2026
This week on Politics Unplugged, Amy Edwards Holmes, the woman tasked with finding wasteful spending in the state government, explains how the process will work. Then, consultants Dawn Penich and Marcus Dell’Artino discuss the federal government collecting data from Arizona’s 2020 election and the fight over school construction funding in Arizona.
Two arrested after Colorado deputy sees panhandler get into "very expensive sports car"
A man and a woman allegedly begging for money to fund their cross-country travels in a stolen car were arrested this week in Colorado.
Jamie Lee Curtis tears up remembering Nicole Kidman's touching first words to her when they met at the Oscars
Jamie Lee Curtis got choked up at a SXSW panel this weekend recalling Nicole Kidman's touching first words to her when they met at the 2022 Oscars: 'I see who you are.'
Microsoft released Windows 11 KB5079471 OS recovery update
Microsoft this week has released a new dynamic update for Windows 11 26H1, 25H2, and 24H2, under KB5079463 and KB5079471.
Top Stories: Apple's 50th Anniversary, New and Upcoming Products, and More
After Apple's big week of announcements, this week saw all of the new products officially become available, so reviewers and general users alike are now getting their hands on them and putting them through their paces.
New Turn-Based RPGs To Play - March 14, 2026
The new mid-March recap is here, and once again this week I’ve got plenty of interesting titles to show you, all ready to be played. Meanwhile,
This Week in Science: Cosmic Fireball, Glowing Forests, And Much More!
Our weekly science news roundup.
Broncos Country underwhelmed by Broncos free agency moves
Based on results of our FanDuel SB Nation Reacts survey earlier this week, it is pretty clear what Denver fans think of the team signing ONLY Broncos free agents. Not thrilled. At the time of the survey, the Broncos had re-signed Alex Palczewski, Adam Trautman, Alex Singleton, Nate Adkins, and Justin Strnad. Since then, they […]
Polly Baca elected to DNC
Forty-Five Years Ago This Week: After her loss to Republican U.S. Rep. Hank Brown the previous year in the race for the 4th Congressional District, state. Sen Polly Baca-Barragan, D-Thortnon, was elected as one of the three vice-chairs of the Democratic National Committee. “It was exciting but a lot of hard work,” Baca-Barragan said. “I […]
High gas prices can make Costco's membership math look better
Average US gas prices topped $3.60 this week. Costco, meanwhile, sells gas for about $0.20 less than nearby stations.
Opposition Lowdown: Tom Cleverley’s Plymouth Argyle
Reading return home to the SCL Stadium this weekend when they take on Plymouth Argyle. Join us as we take a closer look at the opposition.
Escalating war in Middle East, Georgia special election, World Cup
This week's episode is on the impacts of the war, the special U.S. House election in Georgia and the geopolitics of the FIFA World Cup.
MINNEAPOLIMEDIA ENTERTAINMENT | This Weekend in the Twin Cities Entertainment Guide: March 14 to March 15, 2026
Shakespeare. Kurosawa. Irish dance. Wild hockey. Dessa. Food and wine at Target Field. The Twin Cities delivers a full weekend. Pick your stage.
Quiz: This week in politics
It was another busy week in national politics. Take this quiz to see what you know and what you missed.
Quiz: This week in politics
It was another busy week in national politics. Take this quiz to see what you know and what you missed.
Quiz: This week in politics
It was another busy week in national politics. Take this quiz to see what you know and what you missed.