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NYC Health + Hospitals Honors Nursing Home Resident Centenarian Carmen Augustin at Age 112 - NYC Health + Hospitals
NYC Health + Hospitals/Coler honored Carmen Augustin marking her 112th birthday celebration. Augustin is the oldest long-term care resident across the
Sonja O'Hara Developing 'Slay' With Producer Scott Glassgold (EXCLUSIVE)
Screenwriter Sonja O'Hara is developing her feature 'Slay' with producer Scott Glassgold following a competition win, Deadline can report exclusively.
Roadmap Writers, Everard Entertainment Set Sonja O’Hara’s ‘Slay’ For Feature Development Following Competition Win; Scott Glassgold Producing
EXCLUSIVE: Sonja O’Hara has emerged as the inaugural grand prize winner of a new writing competition, aimed at discovering commercially viable short stories for feature adaptation, from Roadmap Writer...
NYC Health + Hospitals/Elmhurst's Mateo Espinosa Named to National Minority Quality Forum's "40 Under 40 Leaders in Minority Health" - NYC Health + Hospitals
NYC Health + Hospitals/Elmhurst is proud to announce that Mateo Espinosa, Assistant Director for Special Projects and Research in Ambulatory Care
Americans Broadly Disapprove of U.S. Military Action in Iran
Most Americans say striking Iran was the wrong decision and disapprove of Trump's handling of the conflict, with stark partisan divides.
Google Claims Android Is Now Faster Than iPhone for Web Browsing
Google today said that Android has set a new record for mobile web performance, making it the fastest mobile platform for web browsing. The newest Android devices have set new records on web performance benchmarks like Speedometer and LoadLine, which Google attributes to "deep vertical integration across hardware, the Android OS, and the Chrome engine".
NYC Health + Hospitals/Woodhull Earns National Recognition as Center of Excellence in Surgical Safety - NYC Health + Hospitals
NYC Health + Hospitals/Woodhull today announced it received the Center of Excellence in Surgical Safety: Prevention of Retained Surgical Items (RSI) Award
iOS 26.4 has fixes for 35+ security issues on iPhone, details here
iOS 26.4 launched yesterday, and alongside new features, it brings over 35 key security fixes for your iPhone per Apple’s notes.
tvOS 26.4 fixes an annoying audio issue on Apple TV 4K
tvOS 26.4 is available now on Apple TV 4K, packing several new features and also a key fix for an annoying audio issue. Here are the details.
Partnership in Action: Reimagining Climate and Health Funding Together
Climate Communities Network members explore funding strategies to sustain community-based climate and health work amid shifting challenges.
Palace Theatre to feature family entertainment with the two Kennys
After years of talking about performing a double header, two of the area’s nationally recognized entertainers will bring their acts to the Historic Palace Theatre on April 4. Ventriloquist and comedia...
Samsung Unveils Galaxy A57 5G and Galaxy A37 5G, Packing Pro-Level Features at Awesome Price
Galaxy A57 5G and A37 5G feature a sleek design, powerful camera, and upgraded Awesome Intelligence to give users the confidence for everyday use
The week in politics (March 25, 2026)
On Wednesday's show: We discuss the latest developments in politics in our weekly roundup. And we consider whether Texas is too big.
Charles County Science Fair Winners Announced Following Annual Expo
WALDORF, Md. – Charles County Public Schools (CCPS) held the 10th annual History, Industry, Technology and Science Expo, also known as HITS, on March 21 at St. Charles High School. Each year the Expo features student history and science fair projects on display for judging. Science fair project categories included behavioral/medicine and health science, chemistry, […]
Science Mill offers three special events in April
Sharing news, features, and sports with the Dripping Springs community. Support local news and subscribe here: linktr.ee/drippingspringsnews.
MY HERO ULTRA RUMBLE : Patch Notes 1.15.0
Through our maintenance update on March 25, 2026, we made the following changes. New features, System Adjustments, Adjustments to Area Control Battle, Battle Style Adjustments, Bug fixes... We hope you continue enjoying MY HERO ULTRA RUMBLE.
Asking Eric: Aunt wants to skip wedding over political divide
A sister is torn between her love for her brother and her disdain for his political views, wondering if attending his daughter’s wedding is a bridge too far. Asking Eric explores the nuance of association. Plus, a couple in their 80s feels …
The Best Noise-Canceling Headphone Deals from Sony, Bose, and Beats for Amazon's Big Spring Sale
Amazon's Big Spring Sale features major discounts on popular headphones like Sony WH-1000XM6, Bose QuietComfort Ultra, and Beats Studio Pro.
8 new emojis arrive in Apple iOS 26.4 update for iPhone users
Along with eight new emojis, the latest Apple iPhone and iPad software update includes new Apple Music features such as AI-generated playlists.
Rowing Science: Hit the Bench Pulls and Dead Lifts, Skip the Squats
A study of German national team rowers found a high correlation between 2000m speed on the erg and o
Students compete at Central Nebraska science fair in Kearney
Organizers said the regional competition featured 40 projects from schools across central Nebraska.
iOS 27 Siri Overhaul: Standalone App, New Design, Dynamic Island Integration and Ask Siri Button
Apple is testing a standalone Siri chatbot app for iOS 27, reports Bloomberg's Mark Gurman. Apple plans to debut a chatbot version of Siri that will compete with Claude and ChatGPT, and the new Siri could be accessible through a dedicated app. Gurman previously said that Apple was not going to develop a standalone Siri app, but it appears plans have changed.
Google TV's new Gemini features keep fans updated on sports teams and more
Three Gemini-powered features are coming to your Google TV. This includes visual responses, deep dives, and sports briefs.
Apple Plans AI Reboot With Siri App, New Look and ‘Ask Siri’ Button in iOS 27
Apple Inc. is testing a standalone app for its Siri voice assistant alongside a new “Ask Siri” feature that will work across the company’s software, part of a broader artificial intelligence overhaul.
Three new Gemini features come to Google TV
AI-powered visual help, deep dives and sports briefs arrive in the US.
Treating addiction
Alcohol and drug addiction can cause many harms. This Research in Context feature looks at research into the causes of addiction and new ways to treat it.
Winners of Science Playwriting Competition Showcased April 15 at Simons Center
The Stony Brook University Science Playwriting Competition brings the sciences and humanities closer together, providing an outlet for scientists and playwrights to venture beyond their normal modes of thinking, spark their imaginations and create new experiences. Rooted in artistic expression, the best science plays can be exceptional works of art that convey scientific concepts aesthetically, potentially
Addressing Concussion Risk and Recovery for Women in Sports
Heather P Adams, MPAS, PA-C, discusses why women in sports may face higher concussion risks and longer recovery times than men.
Three Hawks Named to College Sports Communicators Women's Basketball Academic All-District Team
WEST HARTFORD, Conn. - On Tuesday, the College Sports Communicators (CSC) Academic All-District women's basketball teams were announced with three members of the Hartford volleyball team featured.
Health Care Access for Women: The Cost of Being Dismissed, March 26
The event will feature a panel and table discussions focused on strategies for women to more effectively advocate for themselves in health care settings.
John Fogerty, Cyndi Lauper, more join forces to say 'Thank You, NYPD'
The 'Thank You, NYPD' concert will feature John Fogerty, Cyndi Lauper and Fat Joe, comedians Chris Distefano and Sam Morril, and more.
Just get a new Samsung phone? Turn off these 6 features immediately
Samsung phones are great — but they're even better after you disable some of the default features and settings.
Kalshi says it will crack down on politicians and athletes betting
Kalshi said the new features were aimed at preventing "bad actors" in sports and politics from engaging in insider trading.
CuSTEMized: Personalized Storybooks Inspire the Next Generation of Female Scientists
Custom books feature girls as STEM heroes, aiming to build their confidence and encourage them to pursue their scientific ambitions through storytelling and pictures.
Android Auto is breaking for Pixel and Samsung users, and no one knows why
Users are reporting connection issues associated with a recent update and an Android 16 security feature.
We disagreed on politics. We agreed on wine. That was enough.
At the Virginia Governor’s Cup Gala in Richmond earlier this month, a very dapper gentleman approached me and introduced himself. In his light-colored suit and bowtie, he looked very Southern in a classical sense, the sort of Virginia Gentleman you used to see south of the Rappahannock as recently as my college days. “I’m a longtime reader and fan of your writing, if not your politics,” he said. His comment was the proverbial iron fist in a velvet glove, simultaneously conveying praise and disapproval while establishing boundaries. Man, I wish we still discoursed like this instead of shouting bromides and insults to try and “own” our opponents with a funny meme and a furrowed brow. Subscribe “Well, we’ll always have wine to share together,” I said, and thanked him for his kind words. We clinked glasses, exchanged pleasantries about the delicious gold medal-winning wines being poured that evening, and went our separate ways. Our exchange reminded me that more unites us than divides us. Wine brings people together to share a meal and a few hours of joy despite our differences.1 That’s why I refer to the wine community — including readers and consumers — rather than the wine industry. Together, we are so much more than production, distribution and sales statistics. A few minutes later the evening’s awards ceremony began. Applause grew as the 12 winemakers who made the top-scoring wines for the Governor’s Case took the stage, including a loud cheer for Jonathan Wheeler of Trump Winery and his 2018 Blanc de Noir sparkling wine. All the winemakers on stage had reason to be proud, Wheeler perhaps more so. Trump Winery was the only winery to win six gold medals in the competition this year. (Wineries are limited to six entries.) Two of Wheeler’s ciders also won gold medals in a separate competition. When you cover the labels and take the sour taste of politics off your palate, the wines are pretty darn good.2 Then Gov. Abigail Spanberger, newly elected Democrat and Virginia’s first female governor, was introduced to great applause to announce which of the 12 wines had won the Governor’s Cup. She spoke for a few minutes about the importance of wine to Virginia’s economy and tourism and the international acclaim Virginia wine has received. Just two weeks earlier, she gave the Democrats’ response to Trump’s State of the Union speech, but this night wasn’t about politics. That didn’t stop several people in the crowd from speculating on the irony should she have to present the trophy to Trump Winery. In the end, Valley Road Vineyards was displayed on the screen behind Spanberger as the winning winery. Blue Bee Cidery in Richmond took top honors for that category. The crowd cheered a female governor presenting the state’s highest trophy to a female winemaker and then resumed the evening’s festivities, united by their mutual love of wine. A whiff of politics couldn’t dim the cheer of celebration and a community united by its love of wine. In Memoriam: Michel Rolland The global wine community lost a giant March 20, with the passing of Michel Rolland. He was 78. Rolland was the original “flying winemaker,” a globe-trotting consultant who helped Bordeaux regain its mojo in the 1970s and then shaped the rise of Napa Valley cult Cabernet as consultant to Simi, Harlan, Newton, Screaming Eagle, Araujo, Dalle Valle and other wineries. He was instrumental in Argentina’s rise to prominence and even had his own winery, Clos de los Siete, in a partnership with other wine families. Rolland’s career arc paralleled that of Robert Parker, the world’s most influential critic. Parker championed many of the wines Rolland consulted on, helping build his reputation and demand for his services. It also made him a target for Parker’s critics. As W. Blake Gray wrote on Wine-Searcher in his excellent tribute to Rolland: Rolland created the type of wines Parker loved: rich body, plenty of fruit, soft tannins. He sometimes faced the accusation of creating a generic international style of red wine, where the great wines he made in Argentina were indistinguishable from the great wines he made in France. Rolland chafed at that critique, as did many of his fans. He was credited with championing green harvesting and leaf pulling, as well as careful selection of grapes in the winery, practices we nearly universally think of today for high-quality winemaking. “Michel was an incredible innovator who changed how wine was made and how grapes were grown,” Napa Valley winemaker Aaron Pott wrote on Facebook. “His work has transformed the wine trade. He created new ways of looking at wine, tasting wine, evaluating ripeness and quality. … This was not just a man with a ‘style’ that he imposed on vineyards but a man that understood how to make great wine from great sites.” Rolland started his consulting company in 1973 in Libourne, in Bordeaux, with his wife, Dany. Both had graduated the year before from Bordeaux’s Institute d’Oenologie. The couple sold their majority share in the business in 2020, according to Wine Spectator. Over his career, Rolland reportedly worked with more than 100 wineries in 20 countries. He even made it to Virginia, where he consulted for Kluge Estate in the mid-2000s. (Kluge Estate is now Trump Winery.) Reader feedback, please! Last week, I did my first WineLine Live! with Dr. Laura Catena of Catena Zapata winery in Argentina. We enjoyed a fascinating discussion about her efforts to preserve the genetic heritage of old vineyards in Mendoza. I conceived of WineLine Live! for paid subscribers, as a thank you for your financial support. And while only a few people joined live, the video now has more views than I have paid subscribers, so I guess that’s pretty good. Even so, I’m considering opening future installments to anyone on Substack to reach a broader audience. So my questions to you: Should these be public? And what format do you prefer? Live gives a chat feature with the potential for viewers to interact with me and the guest, while a video post would just be that. Another alternative is a podcast, which would just be audio, without video of my chins. Please let me know in the comments. Leave a comment In the Glass A few wines I’ve enjoyed recently: Bonny Doon Vineyard Take Me to Your Liter, Le Cigare Volant, Red Wine of the Earth. 2023, Central Coast, CA. Blend of Grenache, Syrah Cinsaut and Petite Sirah. Delightful wine with expressive red fruit flavors, casual drinking. Doon lovers of a certain age will remember Randall Grahm’s Big House Red; this is more in that style than his original Le Cigare Volant, modeled after Chateauneuf du Pape. The liter bottle makes it an even better value. I see this online at about $15. Great value. Albert Bichot Bourgogne Pinot Noir Origines 2023. 13% - Textbook pinot noir and an excellent, affordable entry (regional) Burgundy. Wine Enthusiast Top 100 Wines of 2025. $24 at Total Wine & More. Loma Larga Pinot Noir 2021 “Coastal Cool Climate Wine”, Valle de Casablanca, Chile. An older sample, showing beautifully. Spicy and fruit forward. I’m seeing widely varied pricing online, from $18-$32. At the lower end, it’s a terrific value. 13.5% Dr. Loosen Riesling Dry 2016, Mosel, Germany. Found this “in the stack.” And it stacked up well, shedding some of its youthful acidity for opulent Riesling character, including a hint of the mineral oil older Riesling often features. A great value, as I’m seeing it as low as $14 online. 12% abv. Red Tail Ridge Blau Franc Blend 2024, Sans Oak, Finger Lakes. 13.4% abv. The name is a neat portmanteau of Blaufrankisch and Cabernet Franc, thus Blau Franc. The blend is 50-50, no oak involved. The Blau dominates on the palate, with the spicy caraway seed (think New York deli rye bread). The Franc adds body. The result is juicy, energetic and joyful. Sokol Blosser Estate Rosé of Pinot Noir 2025, Dundee Hills, Willamette Valley, Oregon. This first rosé of 2025 was a welcome respite to our cold, snowy winter here in the Mid-Atlantic. Oh man, I needed this! Bright and energetic, exuberant even, it perks up the mood and goes down fast. 13%. Certified B Corp. Ingredient and nutrition labeling, and in a modest way that doesn’t occupy a lot of label space. (Since it’s not required, presumably there are no minimum font size requirements.) More wineries should follow this example. Dave McIntyre's WineLine is a reader-supported publication. To receive new posts and support my work, consider becoming a free or paid subscriber. Subscribe Thanks for reading Dave McIntyre's WineLine! This post is public so feel free to share it. Share 1 Some restraint may be required. 2 Especially the bubblies.
How can you explore careers worldwide? Binghamton student founds club to find out
Binghamton University School of Management student Liam Foley discovers how connecting with diverse cultures creates new pathways for success after founding an international business club.
The Monday Outlook: Project Hail Mary and the Science Behind Blockbuster Sci-Fi
Project Hail Mary is the latest sci-fi blockbuster to stretch the bounds of audience imagination and stir the curiosity of real scientists. But the science driving films like Project Hail Mary, Interstellar and The Martian isn’t all fictional: at UChicago, researchers exploring the cosmos and decoding the origins of life are making discoveries that would feel right at home on the big screen. This week's Monday Outlook features scientists from UChicago and Argonne National Laborat
Babson and Microsoft Team Up to Help Small Businesses with AI · Babson Thought & Action
Students from The Generator, Babson’s interdisciplinary AI lab, worked with small business owners to give feedback on a Microsoft AI tool.
NYC Health + Hospitals/Jacobi | North Central Bronx Brings Novel Minimally Invasive Vascular Surgery Procedures to the Bronx - NYC Health + Hospitals
NYC Health + Hospitals/Jacobi | North Central Bronx today announced it has begun offering two types of minimally invasive surgical procedures that were
Apple to Start AI Comeback Bid on June 8 With Annual WWDC Conference
Apple Inc. announced plans to hold its annual Worldwide Developers Conference from June 8 to June 12, when the company is poised to unveil a make-or-break collection of AI features.
Microsoft-backed startup raises $40 million for advanced chipmaking equipment tech
Lace, a Norway-headquartered chipmaking equipment startup which is backed by Microsoft, has raised $40 million in funding to further develop a technology that could enable significant advances in semiconductor design and manufacturing, the company said on Monday. To make cutting-edge chips, manufacturers such as Taiwan Semiconductor Manufacturing Co and Intel employ a process called lithography that uses light to draw complex circuits that form the foundation of advanced artificial intelligence chips. Manufacturers use light-based lithography systems made by the Dutch company ASML - which dominates the market - as they race to shrink chip components and squeeze in more features to boost the computing horsepower on a limited area of silicon.
Apple Reportedly Preparing 'Biggest Set of iPhone Revamps' Ever
Apple is working on "the biggest set of iPhone revamps in the product's history," according to the latest word from Bloomberg's Mark Gurman. Specifically, he is referring to the long-rumored foldable iPhone, as well as an ambitious 20th-anniversary iPhone with a truly "edge-to-edge" design.
Feature: Where The Heck Do You Start If You've Never Played Resident Evil?
Enter the world of survival horror
By Director Mr. Sakurai, Kirby Air Riders: Development Insights — Part 5 - News
Join Kirby Air Riders director Masahiro Sakurai as he shares insights into the development and details behind some of the game's modes and features. Check out the rest of the interview Part 1: Air Ride and Top Ride Part 2: Cramming everything into S…
Samsung's Galaxy S26 will get Apple AirDrop support starting today
The feature was first launched on Pixel 10 phones last year.
2026 NFL mock draft: Surprises in top 10 of latest first-round projection
The 2026 NFL Draft is just a month away, and our latest mock draft features a few surprises materializing in the top 10 picks.
Florida dogs featured in TCPalm articles for National Puppy Day
National Puppy Day is March 23. TCPalm has articles, videos and photo galleries about dogs. Do you have a dog? What's their name?
Tribune All-Area girls' basketball team full of winners
2025-26 Tribune All-Area girls' basketball team features a group of winners, boasting a ton of talent on the hardwood.
Winners and losers from first weekend of the NCAA tournament feature John Calipari, Darryn Peterson, Big Ten and blue bloods
These Michigan U.S. Senate candidates took money from ICE contractors
Anti-ICE messaging is expected to be featured prominently in Michigan's hotly contested U.S. Senate Democratic primary.
Two new features are officially announced today for the Google Messages app
Google makes it easy to notify members of an RCS group chat while your wife isn't the only reason you're taking out the trash.
The 3DFX Voodoo Lives Again In An FPGA
The 3DFX Voodoo was not the first dedicated 3D graphics chipset by any means, but it became the favourite for gamers among the early mass-market GPUs. It would be found on a 3D-processing-only PCI …
Crimson Desert March 23 Update 1.00.03 Released
Pearl Abyss has just released Title Update 1.00.03 for Crimson Desert and shared its full patch notes.
Eye of Terror – New rules for Defilers, Mutilators, and Kravek Morne
See the new datasheets now.
Binghamton ranked No. 1 public business school in New York state
The Binghamton University School of Management jumped ahead in the prominent Best Undergraduate Business Schools of 2026 ranking by Poets & Quants, placing No. 1 among New York state’s public business schools.
Lessons from Binghamton led alumni award winner to public health
Clare Biging ’16 is an epidemiologist and public health advocate at the New York City Department of Health and Mental Hygiene.
Google Tested AI Headlines In Discover. Now It's Testing Them In Search
Google is testing AI headline rewrites in Search using similar language to the earlier Discover test that became a feature.
Samsung Brings AirDrop Support to Quick Share with Galaxy S26 Series
Samsung is introducing AirDrop support to the Galaxy S26 series, making it easier for users to share content between devices using Quick Share. The feature will begin rolling out from March 231, starting in Korea and expanding to more regions including Europe, Hong Kong, Japan, Latin America, North America, Southeast Asia, and Taiwan. AirDrop support […]
Your Thymus and Your Healthspan
Our thymus gland plays a central role in the development or our immune system, specifically for supporting T cell development (how these cells got their name, maturation and differentiation in the thymus) and discriminating between self and foreign, non-self antigen proteins with production of dendritic cells. As we age, our thymus gland shrinks—the process known as involution—with progressive change from spongy to fatty tissue, with loss of functionality. But this process, with respect to timeline and extent, markedly varies from one person to the next. And to make things even more complicated, our thymus gland anatomy and precise location in the chest also is highly variable. So the famous Frank Netter diagrams from the 1960s (such as at left below) don’t capture the remarkable heterogeneity that a random set of 12 chest CT scans (below at right). What I consider as 2 landmark papers in Nature this week (here and here) used AI to quantify health of the thymus in 2 large cohorts, and then correlate the metric to a broad array of health outcomes. In this edition of Ground Truths, I’m going to cover three questions: (1) How was thymus health determined by AI?; (2) How is thymus health linked to key clinical outcomes? and (3) Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? Subscribe 1. How was thymus health determined by AI? This was accomplished by extensive work developing and validating an AI pipeline for 2 stages, the first for localization and segmentation of the thymus bed, and the second to quantify a digital marker, termed the thymic health score. There’s a lot to this algorithmic development, so I won’t go into all the details, but just provide a rudimentary outline of what was done. The 1st stage used supervised learning with 2 radiologists reviewing 2,461 chest CT scans. That work trained a 3D U-Net model to automatically identify the thymic bed’s 3D cropped region using center of mass coordinates, which reached 99.8% accuracy. The 2nd stage used a foundation model that was pre-trained with SwAV (which stands for Swapping Assignment between multiple Views), a self-supervised model, that generated a high-dimensional thymus representation of 4,096 features. That compares to the radiology reductionist and subjective scoring of 0 to 3 where 0 means the thymus is fully degenerated and fatty, and 3 is considered dense, intact glandular soft tissue. Notably, the self-supervised learning (SSL) performance was superior to supervised (AUC ~0.75 vs 0.55, respectively) reflecting the shallowness of the 0-3 classifier vs SSL’s holistic, self-taught AI. The thymic health score ranged from 0 to 100, with the highest number indexed to fully preserved thymic health. The algorithmic work extended to explainability with both Shapely value distribution, meaning the model was holistic not relying on any “magic” pixel, and occlusion sensitivity, demonstrating the model’s performance was not affected by ribs, sternum, lung tissue, but rather focused on the thymic bed directly. Below are a few saliency maps from the occlusion sensitivity that indicate the thymic bed focus, not affected by neighboring structures, using the jet color scale. Now the AI was ready for processing ~25,000 CT scans, each over 30 MB files, from the 2 large participant cohorts to provide a thymic health score, it did so in less than 14 hours, which is less than 2 seconds per scan! Share 2. How is thymus health linked to key clinical outcomes? The two cohorts were the National Lung Screening Trial, NLST (N=25,031) and the Framingham Heart Study, FHS (N=2,581) each with baseline demographics and long term follow up of >12 years for health outcomes. From the NSLT, you can see below that increased age and body-mass index were correlated to reduced thymic health. And, overall, men had reduced thymic health scores compared with women. There are a lot of graphs in the paper for outcomes, for both the NLST and FHS cohorts. To simplify the major outcomes, below is a composite Figure with striking reduction of all-cause mortality and for the different causes of death. The results were consistent between the 2 cohorts. For example, the cardiovascular mortality hazard ratio average was 0.57 in NLST and 0.38 in FHS (weighted to be 0.53 for the aggregate). The reduction of mortality also extended to digestive diseases and pulmonary disease (data not shown below). Lung cancer incidence was reduced by 36% for high vs low thymic health (Figure below, with a panel -incidence and b panel-mortality, adjusted for age, sex, BMI, smoking status). Notably, there was a smoker’s paradox: lower incidence and improved survival for lung cancer in smokers who had a high thymus health score. Smoking was associated with lower thymic scores whereas alcohol was not. Higher thymic health was linked to higher HDL cholesterol, lower triglycerides, lower fasting blood glucose, and lower systolic and diastolic blood pressure. Inflammation biomarkers, such as C-reactive protein and interleukin-6, were elevated in the people with lower thymic health scores. In their second paper, the same team looked at the relationship between thymic score and outcomes for 3,476 patients receiving cancer immunotherapy. The non-small cell lung cancer progression-free survival was reduced in patients with low thymic health score. A parallel relationship for survival was seen for other types of cancer including melanoma, breast, and kidney with a 44% lower risk among high thymic scores (Figure). A similar pattern was seen with different immune checkpoint inhibitors. The thymus health score outperformed programmed death ligand-1 (PD-L1)and tumor mutation burden (TMB) assay of the tumor and was an independent prognostic marker of progression-free survival. In this dataset, a direct connect with thymus score and adaptive immune function was noted with a correlation before cancer treatment for both T-cell diversity and thymus T-cell production (a metric known as T cell receptor excision circles). Thymus Removal Study There is a highly relevant citation about thymus function before moving onto ways to rejuvenate it. In 2023, a very important study of thymus removal during cardiothoracic surgery was published, with 1146 patients undergoing thymus removal vs 1146 matched controls (mean age 55 years). The adverse outcomes for thymus removal were striking, with a 2.9 higher risk of all-cause mortality and doubling of cancer incidence, 1.5 fold increase in cancer mortality, and 1.5-fold increase in autoimmune diseases. The immune function showed marked compromise after thymus removal, as reflected by CD4+ and CD8+ T cells (Figure below) Share Ground Truths 3. Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? In recent months we’ve learned a lot about the process of thymus involution and the pathways by which this may be modulated. Thymus involution is primarily due to loss to thymus epithelial cells (TECs) and there are 2 subtypes with different functions: the cortical, responsible for positive selection of T cells, and the medullary, for negative selection. When adipose tissue infiltrates the thymus, thymic adipocytes are pro-inflammatory, knocking out T-cell output. Likewise, systemic inflammation, or “inflammaging,” from smoking, obesity, and chronic stress promote thymic adipocytes. Now, from preclinical studies, we know about key pathways that account for these processes. Historically, back in 2014, FOXN1 was recognized as a single master transcription factor essential for TEC function, with studies in mice with forced FOXN1 upregulation leading to thymus regeneration. That laid the foundation for potential regrowth of quiescent thymus cells. It took awhile to find pathways to accomplish this goal and to even refute its role as the master regulator. The Liver-Thymus Axis Feng Zhang and his team recently showed that injection of an mRNA vaccine to the liver encoding DLL1, IL-7 and FLT3-L in combination, factors known to support thymopoiesis (Figure), successfully enhanced immune function in aged mice. However, the effect was transient. The FGF21 Story Two reports in 2025 addressed the thymus gland’s production of FGF21, a growth factor (fibroblast growth factor 21) and its control of thymus involution. This growth factor is also produced by the liver, but it doesn’t have impact on the thymus in aged rodent models. In contrast, The liver’s hepatocyte growth factor (HGF) has been shown to reverse senescent TEC structural changes. Growth hormone stimulates production of insulin growth factor-1 (IGF-1) in the liver and the thymus. Two small studies in human participants (TRIIM, for Thymus Regeneration, Immunorestoration, and Insulin Mitigation) of 6 and 50 people, respectively, treated with combined human growth hormone, metformin and DHEA, suggested the potential of slowing epigenetic aging and improving thymus mass and function. But the combination of drugs, small sample, and lack of controls make conclusions murky. Increased thymus FGF21 led to increased CD8 T cells in old mice and extended healthspan and improved physical performance. Building on the previous FOXN1 data, ablation of β-klotho, the obligatory co-receptor for FOXN1, accelerated thymic aging. The benefit to FGF21 was confirmed in a companion paper using an FGF21 knock-in mouse model showing thymus enlargement and increased TECs throughout the lifespan. (schematic Figure below). The accompanying editorial for these 2 papers speculated: “The proposed link between age-associated thymus involution and organismal aging is intriguing, and suggests we might seek to achieve systemic rejuvenation by counteracting thymic involution.” Other Factors Lessons from the Axolotl (Mexican Salamander) In an elegant set of experiments of the axolotl (Figure), known for its complete thymus regeneration after total surgical removal, mediators were identified. Surprisingly FOXN1 was dispensable. But midkine, a growth factor, appeared to be the driver, the initiator of thymus cell growth, survival, and repair. Other components that contributed were Postn+ (periostin-expressing mesenchymal niches) and Ccl19, a chemokine protein from the bloodstream. RANK and RANKL RANK (receptor activator of nuclear factor κB its ligand (RANKL) have been considered key regulators of medullary TECs. In a study of both aged mice and human thymus cell cultures, their key role was confirmed, with multiple benefits of resorting TEC function, recruitment of progenitor cells, and T cell development. Subscribe Summing Up This body of work strongly supports the health of the thymus gland as a critical regulator of human healthspan, not just a correlate or link. The new landmark studies are reinforced by the regenerative biology experimental models that have shown, via an array of mediators, that healthspan of aged mice is at least in part dependent on thymus gland function and its critical role for maintaining adaptive immunity. It sure seems that we’d be better off having an immune reservoir of naive T cells instead of a profile in older adults of exhausted, low quality, memory T cells, with a senescent phenotype. It is striking that we ignored the importance of the thymus gland for many decades. A wake-up call was the results of the thymectomy matched control study reviewed here, with the opposite of high thymic health score improved health outcomes. The convergence of AI and healthspan here is notable. The exceptional and laborious work for developing and validating (no less explaining) the AI to quantify thymus health set the foundation for probing the connect the major health outcomes in two cohorts with extensive follow-up. We’ve never had a way to meaningfully quantify the thymus gland before, so this represents important leverage of supervised, self-supervised, and transformer models. The study wouldn’t have been possible without AI. And it begs the question as to whether there are ways we can maintain our thymus at a high health score. But it’s not so simple to rejuvenate our thymus. There are multiple risks including the induction of autoimmunity, increasing the risk of cancer, and inducing a pro-inflammatory state. For example, factors that increase TEC proliferation could compromise the medulllary negative selection process and leak out auto-reactive (self-attacking) T cells. Thymic cells could be induced to proliferate, but we know, for example, that growth hormone and IGF-1 are associated with an increase risk of cancer. If thymus rejuvenation doesn’t clear out the accumulated senescent cells in older adults, then inflammation within the gland could block the production of TECs. Keeping these risks in mind, we now have identified many ways to keep our thymus healthy as we age that undoubtedly will be tested in clinical trials going forward. Ultimately, the benefit-to-risk tradeoffs will be defined. In the meantime, we have desperately needed an immunome. As I’ve stressed in multiple prior Ground Truths, we have no test in the clinic to assess a patient’s immune status! It was very encouraging for me to get an email from Hugo Aerts, the senior author of the landmark papers in the days after they were published: “I also wanted to say that your Substack on “Why We Need an Immunome” was inspiring for this work. We found it a very compelling perspective and greatly enjoyed reading it.” Just having an assessment of a person’s immune status via a chest CT scan, with millions of these performed per year, might help in guiding the right immunotherapy for cancer (e.g. more intensive, combinations for those with low thymic health scores) and help define people who are increased risk for age-related diseases of cancer, cardiovascular, and neurodegenerative. The main theme of Super Agers is that we now have many layers of data (genetics, proteins, biomarkers, organ clocks that can be integrated via multimodal AI) for us to define a person’s specific risk decades before one of these age-related diseases leads to symptoms, enabling prevention. From the new studies this week, we can add thymus health score as yet another way to understand a person’s risk, a window into their adaptive immune system and healthspan. And perhaps someday we will be able to safely rejuvenate the thymus, or maintain its health through one’s life, and use the thymus health score to monitor. NB: I wrote this post (No A.I.) A Quick Poll Loading... ********************************************************************* Thanks to Ground Truths subscribers (now > 200,000) from every US state and 212 countries. Your subscription to these free essays and podcasts makes my work in putting them together worthwhile. Please join! If you found this interesting PLEASE share it! Share Ground Truths Paid subscriptions are voluntary and all proceeds from them go to support Scripps Research. They do allow for posting comments and questions, which I do my best to respond to. Please don’t hesitate to post comments and give me feedback. Let me know topics that you would like to see covered. Leave a comment Many thanks to those who have contributed—they have greatly helped fund our summer internship programs for the past two years. It enabled us to accept and support 47 summer interns in 2025! We aim to accept even more of the several thousand who will apply for summer 2026.
The '80s Car Feature That Would Fit Perfectly In The AI Hellscape Of Today
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Science Central: Planetarium opens this week
Wednesday at 10:30 there will be a ribbon cutting unveiling the 1,830-square-foot planetarium features a 21-foot-high, 28-foot-wide dome.
Apple Has Released More Than 10 Products and Accessories This Month
It has been a busy March for Apple, which has unveiled more than 10 products and accessories this month. However, aside from the all-new MacBook Neo and Studio Display XDR, the devices received faster chips or new colors and little else.
Square Enix announces it will integrate Google’s generative AI Gemini into popular online game Dragon Quest X
Square Enix has found a use for Google’s generative AI Gemini and will be putting it to use in the popular online game, Dragon Quest X. Gemini will be used in-game as a feature that allows players to…
Oscar-Winning Alumnus Returns to Pasadena’s ArtCenter for Entertainment Design Expo
One week after winning the Academy Award for Best Animated Feature, KPop Demon Hunters co-director Chris Appelhans returns today to ArtCenter College of Design, the Pasadena campus where he studied illustration, for the college’s third annual Entertainment Design Expo. The expo, known as ENTX, opens the Hillside Campus to the public for a full day of gallery exhibitions, game playtesting, animation screenings and interactive experiences featuring work from more than 200 ArtCenter students and alumni. General admission is free with advance registration. Two industry panels — including Appelhans’s talk — require $15 tickets. Appelhans, who graduated from ArtCenter with a bachelor of fine arts in 2002, co-directed KPop Demon Hunters with Maggie Kang. The animated film, produced by Sony Pictures Animation and released on Netflix, became the streaming platform’s most-watched film in history, according to Netflix, and swept awards season with wins at the Golden Globes, the Annie Awards and the Grammys before taking the Oscar on March 15. His talk and audience Q&A is scheduled from noon to 1 p.m. in the Ahmanson Auditorium. Doors open at 11:30 a.m. The film’s ArtCenter ties extend beyond its co-director. Art director Angela Sung, cinematographer Gary H. Lee, visual development artist Celine Kim and painter Simon Baek are all ArtCenter graduates who worked on the production, according to the college. The free portions of ENTX include a concept design showcase, a production design gallery, a model gallery, a stop motion studio preview, an alumni gallery and a KPop Demon Hunters fan art gallery. Visitors can also playtest games designed by ArtCenter students. An Animation Shorts Showcase runs from 2 to 3 p.m. and includes “Boy, I’m Scared,” a capstone short by ArtCenter graduate Lindsey Tenaglia that was named a semifinalist for the 2025 Student Academy Awards in the animation category. Also screening
Acuff scores 36 as Arkansas holds off No. 12 seed High Point 94-88
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Dynamax Regice Max Monday: Event Guide
Max Monday features a different Pokémon in power spots for the whole day. Regice Max Monday takes place on March 23rd, 2026. This Max Monday is the fourth March Pokémon, and it is the debut of the legendary Ice Pokémon Dynamax Regice! Dynamax Regice is a Tier 5 Max Battle in Pokémon GO. It will cost […]
ESP32: When Is A P4 A P4, But Not The P4 You Thought It Was
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ENTERTAINMENT: Walton Arts Center’s lineup features 5 Broadway shows
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iOS 26.4: Top 10 New Features Coming to Your iPhone
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Apple Has Unveiled 9 New Products This Month
Apple has unveiled a whopping nine new products so far this March, including an iPhone 17e, iPad Air models with the M4 chip, MacBook Air models with the M5 chip, MacBook Pro models with M5 Pro and M5 Max chips, the all-new MacBook Neo, an updated Studio Display, a higher-end Studio Display XDR, AirPods Max 2, and Nike Powerbeats Pro 2.
Hawaiian Airlines Boeing 787-9 Dreamliner business class review
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iOS 26.4 will automatically turn on strict security feature for all iPhones
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Should I care about Tom Brady, Logan Paul and flag football? I need to know
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Radial Entertainment to Distribute Sci-Fi Feature 'Signal One'
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iOS 26.4 adds brand new widgets for your iPhone’s Home Screen
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[VIDEO] Lucy Wang Featured in Business Interview TV Series
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Apple to Launch More New Hardware This April
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Apple Announces New Mac Sales Record Following MacBook Neo Launch
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Galaxy S26 Ultra Enterprise Edition is here with advanced security features
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Google Messages is getting the one feature I’ve actually wanted for years
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Anthropic just shipped an OpenClaw killer called Claude Code Channels, letting you message it over Telegram and Discord
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Markiplier to Microdramas: The Ankler x NAB Show’s Future of Entertainment
Share Subscribe Vegas, baby! The Ankler is heading back to NAB Show for a second year in a row — and doubling down on conversations with the smartest people in the industry. From April 18–22, we’re partnering again with the industry’s biggest media and tech gathering to break down the Business of Media and Entertainment as it’s actually evolving: faster, riskier and increasingly driven by new formats, new audiences and new power players. This curated series will bring together top creators, executives and innovators to tackle the forces reshaping the industry — from the AI disruption of Hollywood’s creative ecosystem to the rise of the creator economy, shifting audience behavior and the changing economics of production. We’ll be rolling out more programming in the coming weeks — including top speakers from leading AI studios, prediction markets and beyond — so keep an eye on the Business of Media and Entertainment hub. But first up, we’re announcing two panels about what’s actually working in Hollywood: The Scary-Smart Business of Horror A good scare has become one of the entertainment economy’s most reliable engines. With disciplined budgets, built-in fandoms and global box office upside, horror consistently outperforms. From theatrical releases to streaming-first originals and creator-driven IP, the genre is artistically flexible and financially durable — and one of the last truly communal experiences for Gen Z and Gen Alpha audiences. Join YouTube creator Mark Fischbach, aka Markiplier, whose independent feature Iron Lung earned more than $50 million at the global box office, Atomic Monster president Michael Clear and screenwriter Akela Cooper (M3GAN, Malignant) for a conversation moderated by Like & Subscribe’s Natalie Jarvey about why horror travels so effectively across platforms and borders, how studios and independents are building sustainable genre pipelines and why the next wave of breakout franchises may emerge from unexpected sources. Inside the Microdrama Boom Short-form serialized storytelling is having a major moment. Microdramas, social-native series and creator-led narratives are capturing massive audiences with low-cost, rapid production cycles and direct-to-fan distribution. What was once dismissed as niche or experimental is now attracting major platform investment. Moderated by Jarvey, this panel of microdrama creators and executives — including one of the format’s top stars and producers, Kasey Esser, and Dhar Mann Studios’ head of vertical content, Erin McFarlane — examines how format innovation, fandom dynamics and algorithmic discovery are reshaping the economics of scripted storytelling and what traditional studios can learn from these agile models. For sponsorship opportunities, contact Lynne@theankler.com Share
New dispute emerges around Subnautica 2’s early access release
Lawyers for the ousted—and now partially reinstated—leadership team of Unknown Worlds, the studio behind Subnautica 2, are crying foul over news that the game will be released into early access in May. The release announcement earlier this week was made improperly, potentially “damaging the game and sowing additional confusion among the Subnautica community,” the lawyers said in a letter sent on Tuesday to Vice Chancellor Lori Will of Delaware’s Court of Chancery. In their letter, the lawyers also floated the idea of asking Will to find Krafton in contempt of the court’s ruling. The letter was sent just one day after Will’s bombshell ruling that publisher Krafton had breached its contract with Unknown Worlds’ executive team, when it fired them last June. The new issue isn’t necessarily the May early access timeframe, but how the news was announced. The letter and Krafton’s response have not been previously reported. A quick recap of prior events: Subnautica 2 is an unreleased, underwater survival adventure and the most-wishlisted game on Steam. Last year, longtime Unknown Worlds CEO Ted Gill, along with studio co-founders Charlie Cleveland and Max McGuire, were fired by Krafton. They swiftly sued, saying the publisher had terminated them to avoid paying out up to $250 million in potential performance-based bonuses. The studio leaders had hoped to earn that with an early access release of the game, which Krafton had blocked. The publisher argued in court that Subnautica 2 wasn’t ready, which the ousted execs disputed. On Monday, Will ruled that Krafton had violated its contract, firing the execs to avoid the performance payouts, and that it had to reinstate Gill and give him full authority over any early access release for Subnautica 2. On Tuesday, IGN reported on a new memo issued that day to Unknown Worlds staff by Steve Papoutsis, the executive Krafton had put in charge of Unknown Worlds after the 2025 firings. In the note, Papoutsis said that Subnautica 2 had passed a key development milestone “last week” and that he and Krafton had determined the game “is ready for Early Access release in May.” This news appeared to catch the lawyers for Gill, Cleveland and McGuire by surprise. On Tuesday night, they sent a letter to Will expressing “serious concerns” about whether it would be possible to forge an agreement with Krafton consistent with the judge’s order. Papoutsis’ memo was a problem, they wrote. He didn’t have the authority to declare anything about Subnautica 2’s release. As of 9am ET on Monday, March 16, the effective date of Will’s order, Papoutsis wasn’t CEO of Unknown Worlds. Gill was. And, per Will’s order, only Gill could make Subnautica 2 release decisions. They continued: Krafton self-servingly announced the launch without any regard to its impact on the game, the team, or the community—let alone this Court’s Opinion. Announcing the release of a game is momentous, and it is typically accompanied by significant marketing activity, fanfare, and community coordination. And most importantly, the announcement is carefully designed to maximize excitement for the game. That entire process was supposed to be driven by Mr. Gill. However, in defiance of the Court’s Opinion, Krafton has now taken that away, further damaging the game and sowing additional confusion among the Subnautica community. The lawyers speculated that Krafton had “intentionally leaked” Papoutsis’ memo and then issued an official statement to confirm the leak. Game File is a reader-supported publication. My reporting is only possible through support from readers like you. To support my work, consider becoming a free or paid subscriber. Subscribe On Wednesday, lawyers for Krafton defended their client in their own letter to vice chancellor Will, saying nothing they did violated her order nor showed contempt: Papoutsis’s message was simply celebrating the UW employees’ efforts toward a past event: Krafton’s pre-Opinion determination that Subnautica 2 was ready for Early Access release. There was nothing improper about conveying the results of the milestone review or thanking the development team for their dedication and talent. They added that Gill could still make his own call about Subnautica 2’s release: In his role as CEO, Gill will be able to assess independently his views on the state of Subnautica 2 and the appropriate release schedule; nothing in Papoutsis’s message alters Gill’s authority or discretion. Vice chancellor Will has not responded to the letters and doesn’t necessarily have to. Both parties were previously ordered by Will to confer this week and submit a proposed judgment consistent with her ruling. The letter from Gill’s attorney’s this week doesn’t indicate whether he would or would not support a May release for Subnautica 2. But it could limit his options. And, if Gill’s lawyers are right, the lack of marketing fanfare around the leak of the May date could dull the launch of the game. Any harm to Subnautica 2’s launch is an extra sensitive issue given the context of the legal dispute: millions of dollars of payouts are on the line, tethered to the scale of the game’s initial performance. In her ruling on Monday, Will noted that there was obvious “bad blood” between Gill’s side and Krafton but that the two would need to work together: “They can—and must—act in good faith to navigate their remaining contractual relationship.” Item 2: A new kind of couch co-op game A highlight of GDC each year is the Alt.Ctrl showcase that features games played with extremely experimental controllers. Perusing this year’s offerings last Friday, I found a game controlled with giant scissors, another with big toothbrushes and one that amounted to dumpster diving. My favorite was Pivot, a co-op game about collectively maneuvering a couch. It was developed by students at the University of Utah’s masters of arts and engineering games program. Players lift and tilt the physical couch in order to control the position of a virtual one. That virtual one is moving through an obstacle course on-screen, while being pursued by a giant skull. Developer Nishant Verma told me at GDC that the couch is made of styrofoam (this became more evident as I watched!) and that the name was a riff on an episode of the sitcom Friends. Item 3: In brief… 🚫 Ubisoft is laying off more than 100 workers at its Red Storm studio, as the North Carolina location known for decades for its Tom Clancy games, ceases in-house game development, VGC reports. 👀 On Monday, Nvidia’s revealed its DLSS 5 AI-driven graphics technology that purports to improve game graphics… and it has been roasted about it by the media and the online gaming public for the remainder of the week. The tech changed the faces of characters in footage from Resident Evil Requiem, Hogwarts Legacy and EA Sports FC, drawing accusations of giving carefully art-directed games the generic look of AI “slop.” Nvidia CEO Jensen Huang had said on Monday that “DLSS 5 is the GPT moment for graphics—blending handcrafted rendering with generative AI to deliver a dramatic leap in visual realism while preserving the control artists need for creative expression.” By mid-week, Huang was telling Tom’s Hardware that the new tech’s critics were “completely wrong” because game-makers could still “fine-tune the generative AI” to suit their game’s aesthetics.
Be counted among the Capital Region’s top private companies
Each year, Business Report ranks the Top 100 Private Companies in the Capital Region — one of our most anticipated and widely read features. It’s the definitive look at the companies driving growth, investment and job creation across our market. If your company is privately held and headquartered in the Capital Region, we want to […]
Firefox Is Adding a Free Built-In VPN. Here's What It Means for You
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Apple Health integrates with newly announced 'Perplexity Health' AI feature
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True Bill Talk: Prosecution & Politics
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Tinder Plans to Let AI Scan Your Camera Roll
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University of Montevallo’s Stephens College of Business Sales Team Earns Top Finish at National “Selling with the Bulls” Competition
The University of Montevallo’s Stephens College of Business Sales Team earned a fourth-place overall finish in Flight 2 at the prestigious Selling with the Bulls Intercollegiate Sales Competition, hosted by the University of South Florida Muma College of Business. Widely regarded as the “toughest test in sales education,” the competition featured 168 student competitors representing… Continue reading University of Montevallo’s Stephens College of Business Sales Team Earns Top Finish at National “Selling with the Bulls” Competition
"Mega Shine" Set Announced for "Pocket!"
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What sports can teach us about Houston: Black Houston(s) Symposium returns to Rice
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One big question: how have increased energy costs affected your business?
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