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Bryan Health receives $750,000 grant to create Rural Family Medicine Residency program
The grant will provide funding over three years to support accreditation planning, curriculum development, faculty recruitment, resident recruitment and other activities necessary to establish a new program.
Canada imposes retaliatory tariffs on U.S. goods, raising concerns for Michigan businesses
Where Michigan voters stand with single-payer health insurance, according to poll
Michigan voters were asked in a recent poll how they felt about the upcoming November general election. Some questions focused on Michigan voters’ opinions on the American health care system.
Free classes offer first aid skills for mental health
Astra Mental Health and Recovery has free community Mental Health First Aid classes coming up Sep. 10 and Sept. 23.
Supreme Court rejects Missouri's push to use new Republican-drawn U.S. House map in November
Missouri's new districts were used in the August primaries, but the Missouri Supreme Court ruled in September that the state must revert to districts adopted after the last census.
2026's elections could test how skyrocketing trading on prediction markets affects races and results
Officials' fears revolve around the fear that pervasive financial incentives will further damage confidence in elections and democracy if Americans think they're influencing the outcome.
Lori Loughlin is divorcing Mossimo Giannulli after 30 years together
“Full House” star Lori Loughlin is formally ending her nearly 30-year marriage to fashion designer Mossimo Giannulli. The 62-year-old sitcom actor said the pair separated on Aug. 31, 2025, according
Snowflake CEO: AI is unleashing a flywheel effect on our business
Snowflake may have a few more surprising quarters ahead as customers pay for added AI services.
Louisville opens first mental health crisis center
Louisville’s first mental health crisis center is now open, offering walk-in help and a new option beyond jail or the emergency room.
Kids hurt, business damaged in drive-by pellet gun shootings
The children were targeted at a grocery store.
Fact-checking Trump's stories about his own 9/11 response
President Donald Trump recounted his response to the Sept. 11, 2001, attacks in an interview and event leading up to the 25th anniversary this week, repeating statements that lack evidence about aiding in the recovery.
The Business of Building a Medical Practice
In this episode of Entrepreneurial Shades of Gray, Dani sits down with Dr. William Boyd, who has spent more than 30 years building and running his own practices.
College Football Has Completely Lost Its Mind
College football has been back for one full week . That’s it. And somehow we already have a tweet perfectly summarizing just how ridiculous this season has become. LSU is dealing with a legal fight that has reached the point where SEC leaders could vote on whether to expel the school from the conference. Western…
Independent Kansas health systems launch shared services organization
Five Kansas health systems have launched a regional collaboration, called Astra Health, to pool resources and coordinate services while retaining their independence. | Astra Health's five founding members, who serve more than half a million patients annually, hope to improve quality and trim costs at scale while maintaining their independence.
DMV high school football rankings (9/8/26)
WASHINGTON (DC News Now) — Here are this week’s high school football top 25 rankings compiled by DC News Now sports reporters Jake Rohm and Alex Flum. Areas eligible for these rankings are based on our coverage zone and viewing area: Washington, D.C., Montgomery County, Prince George’s County, Frederick County (MD), Fairfax County, Loudoun County, […]
Google Cloud Boss Makes Bold Claim About AI Chip Business
In a boost for Google stock, cloud computing chief Thomas Kurian says AI chip business is more than twice the size of its closest rival.
MAC now says Big Ten replay officials erred in adding 1 second back for Michigan's Hail Mary, asks NCAA to recognize Western Michigan as the winner
Former Oregon Ducks Standouts Are Flourishing in the NFL
Multiple former Oregon Ducks stars are thriving in their NFL careers.
Louisiana’s marine research collaboration becomes a political battleground
A select group of Louisiana higher ed leaders are discussing what to do with the state's marine research consortium
“Full House” star Lori Loughlin files for divorce from Mossimo Giannulli after nearly 30 years of marriage
Loughlin and Giannulli both served prison time after pleading guilty in the college admissions scandal.
Lori Loughlin files for divorce from Mossimo Giannulli after nearly 30 years of marriage
Lori Loughlin filed for divorce from Mossimo Giannulli after nearly 30 years of marriage.
Republicans were confident about keeping the Senate. Now the battle is wide open
Republicans appeared to have a firm grip on the majority at the start of the 2026 election cycle. But Democrats are now competing in states that once seemed well beyond their reach.
Accenture and Google Cloud are creating a joint unit to embed AI engineers in enterprises
The Accenture Gemini Enterprise Business Group will train and deploy forward-deployed engineers to help enterprises build and scale agentic AI applications
Louisiana contestant wins first runner-up in Miss America, 'Words that will never seem real.'
After reaching the final five, the current Miss Louisiana came up just shy of the win, but grateful for the experience nonetheless.
Growth in every postcode: good politics, dubious economics
The UK government would be better off backing clusters and widening access to opportunity
Lonnie Bunch to retire from Smithsonian leadership following Trump administration clash
Bunch is going to retire from Smithsonian Institution leadership following an ideological clash.
NYC voters give Mamdani high marks, say mayor is doing better than expected
A new Suffolk University poll also finds New York voters disagree with GOP calls for Mayor Zohran Mamdani to stay away from 9/11 memorial.
In 2018, scientists seeded clouds over China's Muz Taw Glacier to make snow; the brighter surface was followed by 14% to 17% less ice loss in a preliminary experiment
Researchers in China have tried to make artificial snow over China’s Muz Taw Glacier to slow its melting. The experiment conducted in 2018 involved seeding clouds with silver iodide, which helped trigger snowfall over the glacier.
Federal funds headed to Tennessee rural areas lacking adequate healthcare access
The Tennessee Department of Health awarded 53 projects with funding from the Rural Health Transformation Program.
Miley — Bass Persuades: Live at the Hollywood Bowl: Where and when to buy tickets to see Miley Cyrus
Here's how to get tickets to see Miley Cyrus in concert.
State health officials highlight importance of newborn screenings
State health officials are reminding new and expecting parents that a simple test can flag hidden health problems in babies before they become serious.
How to watch the 2026 Emmys: Start time, where to stream, full nominee list and more
Are you ready for the 78th Primetime Emmy Awards?
'Practical Magic 2' review: Sequel honors the original by being a similarly dopey mess
The original "Practical Magic" wasn't a great film — but its fans might appreciate this similarly muddled sequel more than our film critic did.
Scientists find a huge 10-sided pattern in the clouds over Saturn's south pole
Scientists have discovered an enormous 10-sided wave pattern in the icy ammonia clouds over Saturn's south pole
Live Results: Rhode Island midterm primaries
Rhode Island Gov. Dan McKee faces a tough Democratic primary challenge Wednesday in his bid for a second full term.
Live Results: New Hampshire midterm primaries
The race to replace retiring three-term Democratic Sen. Jeanne Shaheen is one of a handful across the country that could determine control of the U.S. Senate for the second half of President Donald Trump’s final term.
North Dakota Today - North Dakota Small Business Development Center
recurring recording of North Dakota Today on KVLY
Lori Loughlin files for divorce from husband Mossimo Giannulli
Lori Loughlin and Mossimo Giannulli are officially going their separate ways.
Lori Loughlin, husband Mossimo Giannulli to divorce after 30 years
Lori Loughlin and Mossimo Giannulli are officially going their separate ways. The "Full House" alum, 62, filed for divorce from her husband of nearly 30 years on Tuesday, Sept. 8,
Moment of Science: Abundant oxygen not enough to explain massive ancient insects, new study suggests
Unlocking answers about giant ancient insects! Here's why an abundance of oxygen 300 million years ago may not explain why some animals got so gigantic after all.
Never watched 'Widow's Bay'? How the creepy comedy became an Emmy favorite.
Matthew Rhys stars in the Apple TV hit that took nearly 20 years to make.
Hidden camera found inside bathroom leads to arrest of Volusia County man, deputies say
He faces 10 counts of digital voyeurism and 11 counts of video voyeurism of a child.
Louisiana concrete companies join forces to capitalize on construction boom
Two Louisiana concrete suppliers are joining forces with two out-of-state companies to pursue large-scale construction projects as billions of dollars in new industrial and technology investment move … Already an INSIDER? Sign in. Already an INSIDER? Sign in
Roundup: Energy employment / Small business confidence / Maritime woes
Jobs in transition: Energy sector employment fell about 1% nationwide and in Louisiana from 2024 to 2025, with Louisiana losing 1,131 jobs to reach roughly 160,000 workers. The decline was driven largely by automation, policy changes affecting renewable energy, and shifting economics, while traditional energy industries such as coal and nuclear saw job growth. Despite […]
AZ's R&D chief Barr touts internal 'science success story' after IL-33 antibody's stellar showing in COPD
With a detailed data drop that AstraZeneca’s R&D chief described as an internal “science success story,” the British Big Pharma has secured an FDA priority review for what it believes could become a flagship biologic in chronic obstructive pulmonary disease (COPD). In detailed results from the late-stage Oberon and Titania trials—first teased in March and detailed in full at the European Respiratory Society Congress in Barcelona this week—the drugmaker laid out the extent of its IL-33 inhibitor’s potential to reduce moderate and severe exacerbations in a wide range of COPD patients still struggling with those “lung attacks,” as AstraZeneca’s Sharon Barr, Ph.D., called them, despite using standard-care inhaled therapy. In the headline results, a 300 mg dose of tozorakimab given once every four weeks curbed those moderate and severe exacerbations in the studies’ primary population of former smokers by 29% in the Oberon study and 34% in Titania. In the overall population of both current and former smokers, these reductions were 30% and 29%, respectively, versus placebo and inhaled standard of care. The benefits also extended to clinically meaningful exacerbation reductions in all prespecified patient subgroups and specifically turned up promising signals in patients across a range of blood eosinophil counts, with Barr telling Fierce that “it’s the details that make this even more exciting than the high-level results that we’ve already shared.” In fact, during AZ’s tozorakimab poster presentation at the ERS 2026 Congress this past weekend, attendees were so enamored by the data that event organizers had to encourage people to clear the room and look at the other presentations on offer, Barr said in an interview. “I think it really speaks to the fact that there is a lot of buzz around these data because the entire respiratory community has been so desperate for new therapies for these patients,” she explained. The respiratory disease continues to represent a “staggering unmet medical need,” Barr said, highlighting the COPD exacerbations that the Oberon and Titania studies homed in on, which she added carry a greater mortality risk than a heart attack. “When a patient has a severe exacerbation, only about half of them are still alive within three and a half years,” she pointed out. As for tozorakimab specifically, Barr christened the molecule “an AstraZeneca science success story,” harkening several years back to the point at which researchers began to explore IL-33 as a driver of respiratory disease, and COPD in particular. At the same time, “there was still so much that wasn’t understood,” she admitted, highlighting the insight that IL-33 signals through both ST2 and EGFR through the RAGE pathway, a discovery Barr attributed to AstraZeneca's own scientists. Understanding the need to tackle both pathways in COPD—and aware of competitor candidates in the hopper, including one that bound ST2—the company ultimately had to make some “courageous decisions,” Barr said. These included taking a prior COPD molecule offline and going back to the drawing board to reinvent its potential IL-33 label “to make sure that we had a molecule that could block signaling through both arms of the pathway, through both the reduced form and the oxidized form, knowing that we wouldn’t be first, but striving to be best.” “When we put [tozorakimab] into the clinic, we firmly believed that we had a differentiated molecule, and we saw the other molecules blocking just ST2 or partially blocking IL-33, unable to deliver two positive pivotal studies in COPD,” Barr explained. “We kept marching forward because we believed our molecule was differentiated, and now I think we have the clinical validation that supports that.” Ultimately, AstraZeneca finds itself on much better footing these days when it comes to potential biologic rivals to tozorakimab in COPD. Sanofi and Regeneron’s Dupixent, for instance, is approved to treat COPD exacerbations in patients with high eosinophil counts, but not low ones. Meanwhile, the future has become cloudier for other next-gen IL-33 candidates from Sanofi and Regeneron, as well as Roche, which have suffered trial flops in recent years. One other potential ingredient for AstraZeneca’s success in its duo of studies was that the company was “ambitious in the trial design, willing to look at an all-comers population,” Barr said, “and willing to enroll the most severe patients.” Prior studies for would-be biologics rivals in COPD “avoided enrolling” those patients, she pointed out. She also highlighted the Big Pharma’s painstaking design of exacerbations in its trial, which “gave us a very rigorous readout,” and pointed to “the extra effort and investment” the company put in to understand the effect of mucus plugs in patients. Barr described mucus production as a “key feature in disease diversity,” noting that mucus plugs—obstructing clumps of mucus that block patients’ airways—are associated with worse outcomes in COPD. In its data announcement, AstraZeneca noted that an integrated analysis of Oberon and Titania found tozorakimab “demonstrated a reduction in patients’ mucus plug score,” with the pharma claiming its biologic is the first to deliver such results in a broad COPD population. “So being able to reduce those mucus plugs, we expect, is an important part of driving benefit for patients who are living with COPD,” Barr said. Again touching on the breadth of the study populations, Barr added that tozorakimab “worked across all eosinophil levels in both current and former smokers across all levels of lung function,” which she suggested “really simplifies decision-making for clinicians, and it allows them to offer therapy to the broadest possible patient population.” In the highest patient eosinophil count group, tozorakimab helped chart a 43% reduction in exacerbation risk, which Barr stressed were “unprecedented data.” In the mid-level group, AZ’s drug delivered a 23% reduction and, in the lowest group, a 34% reduction in eosinophils, which Barr said suggests efficacy “in all patient subgroups.” As for AZ’s recent guidance upgrade on the medicine’s sales opportunity, the lift from a $3 billion to $5 billion range to $5 billion plus was informed by multiple factors, Barr said, including the fact that “in 2024, there were multiple competitors, and there aren’t anymore.” Additionally, “we know that this is a massive unmet medical need, and this is a really incredible set of data that we think will be very convincing to the clinical community,” Barr said. Looking ahead to a potential evolution of the COPD treatment landscape, Barr noted that most patients start treatment in the community with an option like a triple therapy, and for them, having an option like AstraZeneca’s inhaler Breztri will remain a “really important part” of that journey. But of the patients uncontrolled on triple therapy, which Barr described as “about half of them today,” just a “small fraction” are currently eligible for biologic therapy, which she emphasized AstraZeneca is working to change. Understanding that COPD is not a “one-size-fits-all” disease, AstraZeneca is also looking at its antibody drug Tezspire for patients with T2-driven disease, and the company continues to think about new mechanisms for tackling COPD through both systemic and inhaled drugs, Barr said.
New Hampshire voters pick midterm nominees as Sen. Shaheen's exit sparks scramble for key seats
New Hampshire primary voters are choosing candidates for Congress, governor and the 424-seat state Legislature on Tuesday, and incumbents aren’t the only familiar names on the ballot.
Kamin Science Center using multi-day closure to refresh exhibits on all floors
Officials say the museum is using the mid-week closure to refresh and maintain exhibits and visitor experience across all five floors.
The Latest: Canada strikes back with tariffs on about $20 billion worth of US goods
Canada struck back at U.S. President Donald Trump on Tuesday with tariffs on about $20 billion worth of U.S. goods, in response to his latest round of tariffs on Canada.
Spirit Halloween stores are already open for the fall season. See southeast Louisiana locations.
As the fall season approaches, Spirit Halloween stores are popping up seemingly overnight. Here’s where to find the costume shop this year.
Intercard is chosen by Family Entertainment Group for its strategic partnership with Topgolf
ST. LOUIS — Intercard is proud to announce that Family Entertainment Group, one of the nation’s premier developers and operators of entertainment experiences, will use Intercard’s cashless te…
Apple’s new CEO John Ternus expected to debut foldable iPhone at event Wednesday
Apple will kick off a new era on Wednesday when CEO John Ternus takes the stage for the first time for the company’s annual iPhone launch event.
Honda brings Mamadou Diallo back to lead its U.S. auto business
Honda brings Mamadou Diallo back to lead its U.S. auto business, giving dealers a familiar executive with deep Honda and Acura experience.
Ashley St. Clair and Alex Gibney on AI and the dangers of Elon Musk
A new documentary about Elon Musk uses an AI avatar to simulate an interview with him, using real quotes.
CNN to host California gubernatorial debate ahead of November election
(CNN) — CNN will host a California gubernatorial debate later this month, just weeks before Election Day as voters in the nation’s most populous state decide who will succeed Democratic
CNN to host California gubernatorial debate ahead of November election
CNN will host a California gubernatorial debate later this month, just weeks before Election Day as voters in the nation’s most populous state decide who will succeed Democratic Gov. Gavin Newsom.
Parakeet Health lands major AI partnership with national dermatology group Qualderm
Parakeet Health landed a major partnership with Qualderm, one of the nation's largest dermatology organizations, as the company looks to apply agentic artificial intelligence to a growing specialty | Parakeet Health landed a major partnership with Qualderm, one of the nation's largest dermatology organizations, as the company looks to apply agentic artificial intelligence to a growing specialty care access problem.
Immune Cells’ Role as Quality Control Boosts Tissue Health
Macrophages maintain the function of certain organs by eliminating waste products. Studying this process could lead to clues for healthier aging.
Joliet Chamber: The value of being connected and why business relationships still matter
With busy schedules and countless demands competing for their attention, simply putting a networking event on the calendar isn’t always enough. People want to know that their time will be well spent.
Giants Survive Cardinals Rally in 11 Innings
Shay Whitcomb’s walk-off heroics secured a gritty San Francisco Giants victory after a late bullpen collapse forced an extra-inning battle against the St. Louis Cardinals.
Rosanne Cash postpones shows over health emergency
Rosanne Cash postpones shows due to health. Discover her musical journey and Johnny Cash's influence.
Rosanne Cash postpones shows over health emergency
Rosanne Cash postpones shows due to health. Discover her musical journey and Johnny Cash's influence.
Rosanne Cash postpones shows over health emergency
Rosanne Cash postpones shows due to health. Discover her musical journey and Johnny Cash's influence.
Ancient Roman fresco and mosaic featuring maritime city unveiled at newly restored Baths of Trajan
Authorities in Rome have unveiled what is believed to be the largest fresco and mosaic complex of ancient Rome.
Accenture and Google Cloud Deepen Partnership with Formation of New Accenture Gemini Enterprise Business Group
Accenture and Google Cloud today launched the Accenture Gemini Enterprise Business Group, a global group designed to help clients scale Gemini Enterprise outcomes in the agentic AI era.
Tyson Cuts Outlook as U.S. Cattle Shortage Hammers Beef Business
Photo credit piter2121 - stock.adobe.comTyson Foods lowered its fiscal 2026 profit and sales forecasts Thursday as the historically tight U.S. cattle supply continues to pressure meatpackers. The company now expects adjusted operating income of $1.85 billion to
BOOK REVIEW: 'Charlie St. Cloud'
In the village of Marblehead, Mass., 28-year-old Charlie St. Cloud has spent his adult years taking care of the lawns and monuments of the cemetery where his younger brother, Sam,
Dolphins news: Malik Willis perseverance, captains named, mores
The latest news from the Miami Dolphins includes Malik Willis’ perseverance, the captains named, Kyle Louis’ position change, and more.
Alabama Department of Mental Health highlights life-saving resources for Prevention, Recovery Months
This September, the Alabama Department of Mental Health and statewide partners are working to raise awareness, fight stigma, and share life-saving resources.
Alabama Department of Mental Health highlights life-saving resources for Prevention, Recovery Months
This September, the Alabama Department of Mental Health and statewide partners are working to raise awareness, fight stigma, and share life-saving resources.
Alabama Department of Mental Health highlights life-saving resources for Prevention, Recovery Months
This September, the Alabama Department of Mental Health and statewide partners are working to raise awareness, fight stigma, and share life-saving resources.
How to watch the 2026 Emmys: Start time, presenters, full nominee list and more
Are you ready for the 78th Primetime Emmy Awards?
The new tax changes every small business needs to know
Principal Tax Research Analyst at the Tax Institute at H&R Block, Carl Breedlove, breaks down what's new for 2026 filers, from higher reporting thresholds to new forms for crypto and digital asset transactions. If you run a small business, freelance, or trade digital assets, here's what you need to know.
Trump threatens Canadian jetmaker Bombardier, which has an extensive US footprint
U.S. President Donald Trump has threatened to ban the sale of aircraft from Canada’s Bombardier unless it manufactures planes in the United States.
Trump threatens Canadian jetmaker Bombardier, which has an extensive US footprint
U.S. President Donald Trump has threatened to ban the sale of aircraft from Canada’s Bombardier unless it manufactures planes in the United States.
Eureka Springs Police Chief creates unique system for enforcing the rules of the permanent entertainment district trial
KY3's Billie Brightman reports.
'The Pitt' led 2026 Emmy nominations. But another show is ahead after the early awards.
The biggest prizes are still ahead, but shows including "Widow's Bay" and "DTF St. Louis" have already made their mark.
Louisville tech firm V-Soft already seeing payoffs from its latest acquisition
V-Soft's acquisition of St. Paul-based Logisolve adds data and AI capabilities, helping the Louisville firm expand its technology consulting offerings.
Case for Gray becoming very hard to make
The optimism that followed Hibs' win in Dundee has well and truly drained from the support after two subsequent performances that fell well short of expectations. A hapless first half, where Hibs chased shadows, was followed by a second half that started brightly but ended prematurely with a ridiculously self-inflicted red card. The promising start to the campaign has quickly evaporated with losses to Gent, Hearts and now St Johnstone.
A new development map of north St. Louis identifies $337 million worth of housing, business projects
Officials say a new development map will help the city as it plots development efforts in north St. Louis areas impacted by last year’s tornado.
Datameds, AI., and Tollo Health Partner with the NFL Alumni Association for Health Lives Here National Campaign Rollout
Stock Titan provides an ultra-fast stock market news feed and multiple tools for traders and investors.
MORNING BUSINESS REPORT: Record number of 401(K) millionaires, colleges facing enrollment cliff
Jane King has these stories and more for your Tuesday Morning Business Report from the New York Stock Exchange.
This creepy 'statue' that looks like a robed figure on Mars gives us the chills. Here's what's really going on | BBC Sky at Night Magazine
The creepy robed statue of a female figure on Mars was spotted by the Spirit rover on the Red Planet in 2007. Here's what it really is.
WATCH | Mobile speech therapy business ‘Speech on the Spot’ helps meet families needs
Stepping inside Speech on the Spot, a mobile therapy business, visitors are greeted by bus walls decorated with stickers of sunshine, clouds and the phrase "Imagination Blooms."
Healthwatch: Survey reveals how social media influences men’s health
A new Cleveland Clinic survey finds that while a majority of men never trust health information shared by influencers, they are still being influenced.
ESPN’s Katie George Just Changed Sideline Reporting Forever
Katie George Is Officially a Sports Media Psycho Some people had a relaxing Sunday. Katie George apparently looked at the sports calendar and said, “Why not do two cities and two sports instead?” George spent Sunday night in Nashville working the nationally televised Ole Miss-Louisville game at Nissan Stadium for ABC. Then came Monday. New…
Asian shares and US futures are mixed, while oil prices creep higher
Asian shares and U.S. futures are mixed after U.S. markets were closed for the Labor Day holiday.
What Farage’s oyster etiquette says about his politics
When it comes to fish, Reform is across the mores
UE men’s soccer set to host Louisville
EVANSVILLE, Ind. (WEHT) — The University of Evansville men’s soccer team is gearing up to host their second ranked opponent of the season in the 22nd ranked Louisville Cardinals. The Purple Aces are still looking for their first win of the season in what has been a competitive preseason so far. UE has played some stiff […]
Phoenix family says call for mental health help ended in deadly police shooting
A Phoenix family says their call to police for help during their son’s mental health crisis ended with him being shot and killed by officers. Phoenix police say 20-year-old Jonathan Marquez Delgado was armed with a knife and ran toward officers. There are different accounts of what happened Sunday morning.
Phoenix family says call for mental health help ended in deadly police shooting
A Phoenix family says their call to police for help during their son’s mental health crisis ended with him being shot and killed by officers. Phoenix police say 20-year-old Jonathan Marquez Delgado was armed with a knife and ran toward officers. There are different accounts of what happened Sunday morning.
A men's health doctor says many men with low testosterone are getting misdiagnosed — and missing lab tests could be why
Sometimes men are treated for depression when low testosterone is the real cause. A men's health physician explains the signs, the tests, and what to do next.
Americans' satisfaction with schools is at a low point, new Gallup poll shows
A new poll shows that only 32% of Americans are satisfied with the quality of K-12 education in the country
Americans' satisfaction with schools is at a low point, new Gallup poll shows
A new poll shows that only 32% of Americans are satisfied with the quality of K-12 education in the country.
Trump wants voters to pretend he’s on the ballot. The Republican Party is going along for the ride
President Donald Trump may try to channel the role of cowboy as he heads to the first-ever off-year Republican convention in Dallas beginning Wednesday.