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OM System PEN review: Get the F out! This camera isn't a PEN-F II – but it's better in every single way
The OM System PEN is the ultimate everyday carry – and in many ways, a better Lumix L10 than the actual L10
Playing politics with security: Jerusalem must review UK privileges amidst sanctions
Britain and Israel have genuine strategic interests in common even when their governments disagree sharply, but diplomatic relations require reciprocity.
Chelsea vs Leeds United – Match preview and team news
Chelsea host Leeds United in the Carabao Cup third round on Wednesday, six months after the sides met at Wembley in last season’s FA Cup semi-final.Xabi Alonso’s side go into the game looking to b...
Three Huber Heights friends created a band that exists only online
Josh Burnette, one third of Dayton genre-blurring virtual band Rose Pedal, produces music with a visual mindset.
Barcelona vs Feyenoord – Match preview and team news
Barcelona will aim to register their fifth straight victory this season when they kick off their UEFA Champions League campaign on Wednesday against Feyenoord at the Camp Nou.Barcelona vs Feyenoord �...
The best business gifts aren’t the most expensive. They’re the most personal.
Louisville businesses are using engraved bourbon bottles to personalize corporate holiday gifts and strengthen client relationships.
TH North Flag Football takes down Northview, 38-18
BRAZIL, Ind. (WTWO/WAWV) — Terre Haute North Flag Football defeated Northview, 38-18 on Tuesday night. The Patriots will be back in action on September 10th at Terre Haute South.
25 years after 9/11, activists continue fighting for healthcare
Lila Nordstrom, the author of "Some Kids Left Behind: A Survivor's Fight For Health Care In The Wake Of 9/11," sits down with NY1's Cheryl Wills.
Archimedes Science Award 2026
Detlef Günther, Swiss Federal Institute of Technology (ETH) Zurich, Switzerland, honored
Seahawks vs. Patriots: Super Bowl Rematch Game Preview
Seahawks vs. Patriots: Super Bowl Rematch Game Preview The NFL season is finally here, and it is opening with one of the most anticipated matchups possible: a rematch of Super Bowl LX. The Seattle Seahawks will welcome the New England Patriots to Lumen Field on Wednesday night, just seven months after Seattle dominated New England…
‘Last Seen’ review: Apple TV mystery thriller gets lost down under
For a show that began as potentially darkly poetic or challenging, "Last Seen" (which premieres Wednesday on Apple TV) plays it far too safe, writes our reviewer.
Hurricane Lowell forces bank closures across Kauai, parts of Oahu and Maui
All major Hawaii banks closed Kauai branches Tuesday as Hurricane Lowell brought high winds, heavy rain and widespread power outages to the islands.
Halo composer Marty O’Donnell takes Nevada race to RNC stage
Nevada congressional candidate and “Halo” composer Marty O’Donnell will speak at the RNC’s Dallas midterm convention as he challenges Rep. Susie Lee.
SK hynix Charts Its Business and Technology Direction at the 2026 Future Forum—”Now Is the Golden Time to Leap Forward”
▲ A panoramic view of the 2026 SK hynix Future Forum venue On September 8, SK hynix held the 2026 SK hynix Future Forum (Future Forum) at the SUPEX Center on its Icheon Campus under the theme, “The Golden Time
Joy Behar achieves major 'The View' milestone
Joy Behar is celebrating her latest career milestone, one "The View" says has made TV history.
The 98 Biggest TV Show Flops, Bombs and Misses in the First Half of 2026
(Welcome to the Entertainment Strategy Guy, a newsletter on the entertainment industry and business strategy. I write a weekly Streaming Ratings Report and a bi-weekly strategy column, along with occasional deep dives into other topics, like today’s article. Please subscribe.) In July, I updated my look at how the “streaming bubble” popped since 2023, showing the decline in streaming TV shows over time. But after compiling and analyzing and writing about over one hundred TV show flops in the first half of 2026—I counted 99 “nominees” and there are even more honorable mentions—I couldn’t have told you that the number of shows is going down. When it comes to scripted, English-language TV shows, it feels like we have as many bombs as ever. I don’t keep a specific count, but some streamers probably had as many flops as they’ve ever had.1 That’s right, it’s time for part two of my analysis of the biggest flops, bombs and misses on streaming in the first half of 2026. Two weeks ago, I took a look at films. Today, TV shows. If you want to read the full methodology for how I assemble this list, you can find it at the bottom of this article. In short, this list is… ...scripted and unscripted TV shows,...from the nine major streamers,...in the US (using US-only ratings),...excluding true crime, kids and foreign-language shows,...that got no/poor ratings,...from Jan-2026 to the end of June-2026. Reminder: this article does not represent my personal opinion—many of these shows are great!—but I follow the data, and a miss is a miss and a bomb is a bomb. Also, price matters. If a TV show costs north of $100 million, it needs to get lots and lots of streaming viewership to justify that budget. As with past editions, I ordered this list by streamer, going from best (fewest flops) to worst (the most misses)—taking the size of the flops into consideration—and like the last edition, three or four streamers vied to take the win/loss of having the most flops. (But the actual winner is no surprise.) I try to avoid tooting my own horn too much, but seriously, in just under 5,000 words (including the methodology section) I provide a mostly comprehensive overview of the eight major streamers (Netflix, Disney+, Prime Video, Hulu, HBO Max, Peacock, Paramount+, and Apple TV) for the first half of the year, mentioning most of their hits and all their misses. It summarizes the entire first half of 2026! If you want to support this work, please subscribe. Subscribe Tubi Big Mood Boarders The Freak Brothers Twenty Twenty Six Honorable Mentions: Busted on Bodycam, Deestroying the Pitch, Destination World Cup 2026 I don’t think that Tubi spends all that much making or (mostly) licensing these original TV shows—Big Mood, Boarders and Twenty Twenty Six all come from the UK—but they’re not free and they didn’t chart anywhere. Winner: The Freak Brothers Have you even heard of this show? It’s an animated comedy...that’s on its third season! And Pete Davidson, Woody Harrelson, John Goodman and Tiffany Haddish all provide voice talent for it. Yes, animated shows don’t cost as much as live action shows, but cheap isn’t free! So a show with this level of talent needs to perform better. Disney+ Daredevil: Born Again Star Wars: Maul – Shadow Lord Honorable Mentions: Behind the Attraction, Donna Hay Coastal Celebrations, We Call It Imagineering Disney+ doesn’t make all that many original shows anymore. They had two flops, and one was animated. Their one not-a-miss show, Wonder Man, got just good enough viewership to not be considered a “miss”...but it’s since been cancelled. At this point, Disney has pivoted entirely away from making big budget TV shows for Disney+ to making...almost nothing for Disney+? Sure, Disney’s spending circa 2019-2022 was unsustainable, but now they’re pivoting too far in the other direction. At some point, Disney needs to stop shifting strategies so wildly. Really, Disney should have made fewer shows for Disney+ at launch and the shows they did make at that time needed to be made at more reasonable budgets. And they should adopt that strategy now. Winner: Daredevil: Born Again Daredevil, the Marvel Comics character, is on my personal Mount Rushmore of favorite superheroes, so it pains me to give him the win/loss today, but this show deserves it. I’ll repeat my hot take from last spring: “Based on his popularity, Daredevil should be in movies, and probably ones that cost a lot less than the MCU’s usual price tag. Disney/Bob Iger/Ike Perlmutter (who, based on reporting, made the decision) made a huge mistake selling TV shows to Netflix in the 2010s, thus limiting this character to the small screen. Daredevil could have anchored Marvel’s post-Infinity War plans, and if he did, the MCU would probably be in a better place than it is now.” HBO Max We’re just getting started with this issue, but the rest is for paid subscribers of the Entertainment Strategy Guy, so if you’d like to find out… What four streamers had the most misses... HBO’s strong start to 2026… The caveat to Peacock’s turnaround this year... Paramount+’s key man problem… What country isn’t delivering hits for Netflix or Hulu... The cavalcade of stars on a streamer where no one is watching their shows... Across nearly 5,000 words of analysis… And a lot more... ...please subscribe! We can only keep doing this great work with your support. If you’d like to read more about why you should subscribe, please read this article about the Streaming Ratings Report, why it matters, why you need it, and why we cover streaming ratings best.
Alaska review finds potential financial disclosure issues involving 91 candidates
A preliminary Alaska Department of Law review found potential financial disclosure discrepancies involving 91 candidates, but did not determine whether any laws were violated.
Dahlstrom reverses course, will certify Taylor and Tagle for November ballot
Lt. Gov. Nancy Dahlstrom reversed her August 31 decision and will certify Treg Taylor and Jose Tagle after a preliminary review raised questions about financial disclosure recommendations.
Faculty Focus: Chris Erickson, College of Business
Chris Erickson has spent 40 years at NMSU as an economics professor, researcher and mentor. Erickson, a professor in the Department of Economics, Applied Statistics and International Business in...
William O'Dowd IV Discloses Investment at Dolphin Entertainment with 19.0% Stake
William O'Dowd IV, the CEO of Dolphin Entertainment, Inc., reported beneficial ownership of 19.0% of the company's common stock. He filed a Schedule 13D on Sep. 08, 2026, after an earlier note exchange and a pre-set buying plan in 2025. The position includes common shares and the right to convert c…
Fact-checking Trump's stories about his own 9/11 response
President Donald Trump recounted his response to the Sept. 11, 2001, attacks in an interview and event leading up to the 25th anniversary this week, repeating statements that lack evidence about aiding in the recovery.
Celo to Participate in Merkle Science Meet in Washington, D.C. on September 8th
Celo will participate in Merkle Science Meet in Washington, D.C. on September 8th at 18:00 UTC. Markus will join a panel on the GENIUS Act and the future of U.S. stablecoin regulation.Refer to the official tweet by CELO:Kicking off @thestablecon week today, @MarkusMento speaks at @MerkleScience Mee…
Sony Music Japan President Atsuhiro Iwakami: Interview
Sony Music Japan President Atsuhiro Iwakami shares his thoughts on what it will take for Japanese content to score hits abroad.
New England Patriots @ Seattle Seahawks Preview And Prediction
The NFL couldn’t have picked a much better way to start the season. Patriots. Seahawks. Super Bowl rematch. Seven months after Seattle beat New England 29-13 in Super Bowl LX , the Patriots return to Lumen Field Wednesday night with a much different team and another opportunity against the defending champions. And this one should…
DMV high school football rankings (9/8/26)
WASHINGTON (DC News Now) — Here are this week’s high school football top 25 rankings compiled by DC News Now sports reporters Jake Rohm and Alex Flum. Areas eligible for these rankings are based on our coverage zone and viewing area: Washington, D.C., Montgomery County, Prince George’s County, Frederick County (MD), Fairfax County, Loudoun County, […]
Exclusive: Two of gaming’s biggest names are making a big investment in gaming’s future
The first thing to know about the Nova Games Foundation is that it isn’t about The Game Awards. And it’s not about PlayStation. The ambitious new grant program is the brainchild of Geoff Keighley and Mark Cerny. Keighley is the host of The Game Awards, Summer Game Fest and Opening Night Live. Cerny is a game designer of some 45 years and the lead architect for the PlayStation 4 and 5. But this new thing, which they’re revealing through Game File, isn’t about their day jobs. It’s an unaffiliated, standalone philanthropic project. It’s a bet on the artistic future of video games and a way, they tell me, to give back. “I’m nearing the end of my career,” Cerny recently told me over email. “I’m not done yet, but paying it forward—in the best way possible—is very much on my mind these days,” The Nova Games Foundation is a university-affiliated fellowship program, intended to offer six-figure grants to 20 young game designers each year, potentially for decades to come. It will offer no-strings-attached funding along with mentorship from games industry leaders, a combination intended to aid the development of groundbreaking new games, Cerny and Keighley told me. Nova will begin accepting applications in December, from class of 2026 and 2027 students from 13 affiliated gaming programs at universities in eight countries. The schools working with Nova include the New York University and the University of Southern California in the U.S., along with Abertay University in Scotland, Cnam-Enjmin in France, TH Köln in Germany, and the Royal Melbourne Institute of Technology in Australia, Cerny and Keighley said. The plan: $100,000 per recipient, with about a quarter of Nova fellows eligible for up to $500,000 more for projects that are shaping up particularly well. Payments will be delivered based on development milestones, and recipients will own their games. Nova will help promote the work, and developers will be free to pursue the publishers and platforms of their choice. Nova can help introduce fellows to publishers, but won’t take a cut. “I’ve always wanted to give back, but given my role in the industry, I’ve never felt it appropriate to commercially invest in games,” Keighley told Game File. “I’ve never owned stock in a game company or taken a financial stake in a game. Nova is philanthropy: we aren’t taking equity or looking to recoup the grants. The return we’re hoping for is creative—helping new voices make games and find their footing. “Mark and I have each made multi-million-dollar donations to establish the foundation, and we intend to keep contributing. We hope others will join us.” Cerny and Keighley have already hired an executive director, John Maconga, and a head of grants, recent Game Developers Conference director Ashley Corrigan, to help launch the effort. They’re working to recruit game industry leaders to join the effort. Keighley says “dozens of leading game directors have already expressed interest in contributing their time.” To name one, they’ve already gotten Josef Fares, lead designer from It Takes Two and Spit Fiction studio Hazelight on board with a donation and pledge to help out. “I’m proud to support Nova because it gives the next generation of creators the freedom to explore their creativity and hopefully bring their unique visions to life,” Fares told Game File. A plan forged from a friendship Keighley and Cerny have known each other a long time. It’s been so long, Cerny isn’t even sure exactly when they met. “We travel in much the same circles and I’m sure first intersected in the 90s or early 2000s,“ Cerny said. Keighley thinks it might have been during his stint writing a column about the mid-’90s console 3DO for a gaming magazine while Cerny was working on games with Crystal Dynamics or on Way of the Warrior with Naughty Dog. They became genuine friends about a 10 years ago, Keighley said, as they bonded over a shared love of games and a hope to improve the industry. “About a decade ago, we started having dinner a few times a year in LA,” Keighley said. “Just to catch up on life and the industry. Those conversations continued over Zoom during COVID. Nova grew out of that friendship and a question we kept coming back to: ‘What could we do to help the next generation of game directors get started?’” Keighley credits Cerny with the idea to figure out a way to put their money and time back into the industry. At one of those dinners, Keighley proposed the idea of a fellowship program. He’d recalled applying for a Rhodes Scholarship when he was younger. “Spoiler: I didn’t get it,” he said. He’d admired the MacArthur Foundation’s so-called “genius grants.” He liked these kinds of programs that recognized people’s talents and gave them the financial boost and the freedom to realize their potential. With Cerny, he had pondered what a game industry version of that could be. Keighley liked the idea of centering the fellowship on students, drawing inspiration from the accomplishments of Jenova Chen, the USC game design graduate who went on to lead the creation of gently moving, ambitious games such as Flower and Journey. Keighley also thought it could be useful to help promising graduates bridge the transition from student to professional. “Joining an established studio isn’t always possible—especially in today’s market—and even then, it isn’t the right path for everyone,” Keighley said. A fellowship, he realized, could give “graduates the time, resources and guidance to pursue a game of their own and not worry about the commercial viability.” As the idea took shape, Cerny also saw an opportunity to enable more games of a certain type: “The target with the grants is games as an artistic medium,” Cerny told me. “We like to say games with ‘artistic, literary and societal value.’” He added: “I’m a pretty big gamer myself, though I tend to gravitate towards the smaller and more unique or artistic titles, games like Neva, Abzu, Gorogoa, Stray or Outer Wilds. I was just playing and Roger on a flight to Japan, and was getting misty eyed to a degree that I was concerned that a flight attendant would ask me if I was OK. “So one fun benefit here is the games that will come out of the Nova Games Foundation – I can’t wait to play them myself.” Cerny believes it will also be useful for Nova fellows to hone their craft and team leadership skills. “We are looking for the next generation of visionaries,” he said. “The trick is that they will also need to have the executive function necessary to drive a small project to completion.” Game File is a reader-supported publication. To receive new posts and support my reporting, please consider becoming a free or paid subscriber. Subscribe Going big with this Keighley and Cerny may have started Nova and may be the ones primarily backing it right now, but they’re dreaming of something that goes beyond them. “Mark and I may have helped get it started, but one of our measures of success is that Nova grows into something the entire games industry feels a sense of ownership in,” Keighley said. “Our ambition is to build a lasting endowment supported by people and companies across the industry, and an equally broad community of creators willing to give their time and experience to the next generation.” The industry has a lot of knowledge that it can pass to the next generation, Keighley said: “Nova can hopefully become a way to connect that generosity with talented young creators at the moment when it can make the biggest difference.” Cerny, who told me he believes Nova can mature “over the next 10 or 20 years,” sees an opportunity to give generations of game makers momentum. “The industry has changed immeasurably since I started in games in 1982,” he said. “These graduates have talent, training and tools that outclass what we had back in the day by an astonishing amount. But they face a tough road ahead getting traction in the industry, and many could benefit from our support. We want to be there to give it to them.” “There’s a personal side to this, too,” Keighley said. “I don’t have children, and I’ve spent a lot of time thinking about what I can do for future generations. Games have been my entire career. I’ve been incredibly fortunate, and helping someone else build a life in this industry feels like a meaningful way to give back.” Cerny’s oeuvre dates back to Marble Madness and Sonic the Hedgehog 2. He has stood on stage multiple times to reveal the future of PlayStation hardware. He’s been an executive producer for a string of modern PlayStation classics such as The Last Guardian and Marvel’s Spider-Man. Nevertheless, of Nova, he said, “It’s certainly not like anything I’ve done before.” Nova Foundation applications will be due in December and the first wave of fellows will be announced in March 2027. A full list of participating universities and steps students and recent graduates can take to apply to become a Nova Fellow is forthcoming.
Is the news stressing you out? MS NOW partners with Calm
MS NOW wants to offer news viewers a break when they feel overwhelmed. The Versant-owned progressive-leaning news outlet announced Tuesday that it has entered a partnership with Calm, the San
Owner seeks second extension for 683-unit Brookland project amid tough market conditions
Jack Sarf seeks another extension on his Franklin & Reed mixed-use development in D.C. as Hanover R.S. LP pulls out due to market conditions.
Brentford's rise 'not finished yet'
From starting his coaching journey with MK Dons in 2015, it took the Ireland international 10 years to become a top-flight manager. "I went on a journey to try to be a head coach, but that wasn't straightforward," Andrews told The Football Interview. Playing his junior football in the Dublin District Schoolboy League, second tier Wolves identified Andrews as a target.
Joy Behar says Whoopi Goldberg has been on“ The View ”so long that ‘she used to be white’
Behar made the joke as she encouraged the audience to celebrate Goldberg’s 20th season at the Hot Topics table.
Santa Cruz County business filings: Week of Sept. 8
Businesses operating in Santa Cruz County must register with the county clerk. Lookout Santa Cruz reviews the public filings from local businesses to report on new businesses starting in the area.
Booster group pushes to keep Downtown Pittsburgh businesses viable
The Pittsburgh Downtown Partnership has sought to bring more small businesses into the Golden Triangle in recent years — and now it’s launching a concerted effort to keep them there. Dubbed Business Boost, the initiative is meant to support small businesses and ensure they can last Downtown long-term, Pittsburgh Downtown
“The View” pulls an Oprah Winfrey, moves audience to tears as ‘everyone’ wins huge prize on season 30 premiere
Whoopi Goldberg announced the stunning moment on air, which made some audience members double over as they cried.
Last Gasps: Mariners vs. Rangers Series Preview
The Mariners must win against the Rangers.
BlizzCon 2026 preview: Speculation, hopes, dreams — what to expect for Warcraft, StarCraft, Overwatch, Diablo, and even more surprises
BlizzCon 2026 is shaping up to be incredibly special this year, with a huge amount of panels, unexpected surprises, alongside some perhaps a-little-more-expected surprises.
SSO to open season with guest conductor
The Southwest Symphony Orchestra (SSO) will present its first concert this season “Inspiration” on Sunday, Sept. 27, at 4 p.m., at Mother McAuley High School, 3737 W. 99th St.
‘The View’ Hosts Miserably Fail Trivia About Their Experiences on the Show: ‘I Have No Idea What That Was’
The hosts of "The View" don't remember a whole lot of what they've done on the show over the years, and proved that on Tuesday
Aaron Rodgers praises Karl Ravech for ‘phenomenal’ ESPN tenure
Aaron Rodgers loves to hate on ESPN, and the Worldwide Leader may have given him a little more ammunition by parting ways with Karl Ravech. Rodgers was recently interviewed by Adam Schein on his SiriusXM Mad Dog Sports Radio show. At the end of the segment, Schein boldly gave Rodgers the open forum to share…
Baptist Health Paducah to offer 'Monday Night Mammograms' during Breast Cancer Awareness Month
Baptist Health Paducah will recognize Breast Cancer Awareness Month by providing Monday Night Mammograms throughout the month of October.
Google Chrome starts two-week release cycle with version 153
As previewed earlier this year, Google Chrome is now operating on a two-week release cycle. Previously, Chrome received...
'Practical Magic 2' review: Sequel honors the original by being a similarly dopey mess
The original "Practical Magic" wasn't a great film — but its fans might appreciate this similarly muddled sequel more than our film critic did.
Dallas Cowboys 2026 Opponent Preview: Tennessee Titans
Which opponent on the schedule worries you the most?
Politics Threaten Medical Innovation at NIH
Santa Monica rheumatologist warns that political interference in NIH funding threatens scientific breakthroughs and patient care. Taxpayer dollars should support rigorous peer review, not politics.
Netflix VP of Global Live Sports & Entertainment on WWE: "They’ve been great partners, and we’re thrilled with the results so far" - POST Wrestling | Podcasts, News, Reviews
Gabe Spitzer, a Vice President at Netflix, spoke with Richard Deitsch on the Sports Media podcast regarding their relationship with WWE.
“The View” pays powerful tribute to Barbara Walters in emotional season 30 premiere: ‘This is that show’ she envisioned
Whoopi Goldberg spoke about how each of the six current cohosts fulfills the late Walters’ desire to highlight the perspectives of an eclectic group of women.
Global report shows where US kids rank in reading, math and science
ABC News' Elizabeth Schulze has the results of a new report released this morning showing where U.S. students rank compared with students around the world.
Player Preview: Nico Onyekwere
The third scholarship returnee looks to make himself known in year two
Review: SteelSeries Aeon Pro: The Infinite Battery Life, Dual-System Xbox and PC Controller Impresses, Despite Its High Price
Borrowing the best ideas from the firm's Arctis Nova Pro headset lineup.
Former Kane Realty COO launches AI-powered real estate consulting firm
Bonner Gaylord and David Shaner co-founded Grounded Intelligence to help Triangle commercial real estate firms implement AI tools for competitive advantage.
No Evidence That Sugar Substitutes Harm Weight, Health, or Sweet Taste Preferences
New review of three major EU-funded trials shows swapping sugar for non-nutritive sweeteners may help with weight loss maintenance, while broader "sweet taste" exposure appears largely neutral for health.
Galaxy Z Fold 8 display corners can bend inward on purpose, Samsung says [Gallery]
The internet is mad. Shocking statement, I know, but this time it’s about a perceived quality control issue on the...
AZ's R&D chief Barr touts internal 'science success story' after IL-33 antibody's stellar showing in COPD
With a detailed data drop that AstraZeneca’s R&D chief described as an internal “science success story,” the British Big Pharma has secured an FDA priority review for what it believes could become a flagship biologic in chronic obstructive pulmonary disease (COPD). In detailed results from the late-stage Oberon and Titania trials—first teased in March and detailed in full at the European Respiratory Society Congress in Barcelona this week—the drugmaker laid out the extent of its IL-33 inhibitor’s potential to reduce moderate and severe exacerbations in a wide range of COPD patients still struggling with those “lung attacks,” as AstraZeneca’s Sharon Barr, Ph.D., called them, despite using standard-care inhaled therapy. In the headline results, a 300 mg dose of tozorakimab given once every four weeks curbed those moderate and severe exacerbations in the studies’ primary population of former smokers by 29% in the Oberon study and 34% in Titania. In the overall population of both current and former smokers, these reductions were 30% and 29%, respectively, versus placebo and inhaled standard of care. The benefits also extended to clinically meaningful exacerbation reductions in all prespecified patient subgroups and specifically turned up promising signals in patients across a range of blood eosinophil counts, with Barr telling Fierce that “it’s the details that make this even more exciting than the high-level results that we’ve already shared.” In fact, during AZ’s tozorakimab poster presentation at the ERS 2026 Congress this past weekend, attendees were so enamored by the data that event organizers had to encourage people to clear the room and look at the other presentations on offer, Barr said in an interview. “I think it really speaks to the fact that there is a lot of buzz around these data because the entire respiratory community has been so desperate for new therapies for these patients,” she explained. The respiratory disease continues to represent a “staggering unmet medical need,” Barr said, highlighting the COPD exacerbations that the Oberon and Titania studies homed in on, which she added carry a greater mortality risk than a heart attack. “When a patient has a severe exacerbation, only about half of them are still alive within three and a half years,” she pointed out. As for tozorakimab specifically, Barr christened the molecule “an AstraZeneca science success story,” harkening several years back to the point at which researchers began to explore IL-33 as a driver of respiratory disease, and COPD in particular. At the same time, “there was still so much that wasn’t understood,” she admitted, highlighting the insight that IL-33 signals through both ST2 and EGFR through the RAGE pathway, a discovery Barr attributed to AstraZeneca's own scientists. Understanding the need to tackle both pathways in COPD—and aware of competitor candidates in the hopper, including one that bound ST2—the company ultimately had to make some “courageous decisions,” Barr said. These included taking a prior COPD molecule offline and going back to the drawing board to reinvent its potential IL-33 label “to make sure that we had a molecule that could block signaling through both arms of the pathway, through both the reduced form and the oxidized form, knowing that we wouldn’t be first, but striving to be best.” “When we put [tozorakimab] into the clinic, we firmly believed that we had a differentiated molecule, and we saw the other molecules blocking just ST2 or partially blocking IL-33, unable to deliver two positive pivotal studies in COPD,” Barr explained. “We kept marching forward because we believed our molecule was differentiated, and now I think we have the clinical validation that supports that.” Ultimately, AstraZeneca finds itself on much better footing these days when it comes to potential biologic rivals to tozorakimab in COPD. Sanofi and Regeneron’s Dupixent, for instance, is approved to treat COPD exacerbations in patients with high eosinophil counts, but not low ones. Meanwhile, the future has become cloudier for other next-gen IL-33 candidates from Sanofi and Regeneron, as well as Roche, which have suffered trial flops in recent years. One other potential ingredient for AstraZeneca’s success in its duo of studies was that the company was “ambitious in the trial design, willing to look at an all-comers population,” Barr said, “and willing to enroll the most severe patients.” Prior studies for would-be biologics rivals in COPD “avoided enrolling” those patients, she pointed out. She also highlighted the Big Pharma’s painstaking design of exacerbations in its trial, which “gave us a very rigorous readout,” and pointed to “the extra effort and investment” the company put in to understand the effect of mucus plugs in patients. Barr described mucus production as a “key feature in disease diversity,” noting that mucus plugs—obstructing clumps of mucus that block patients’ airways—are associated with worse outcomes in COPD. In its data announcement, AstraZeneca noted that an integrated analysis of Oberon and Titania found tozorakimab “demonstrated a reduction in patients’ mucus plug score,” with the pharma claiming its biologic is the first to deliver such results in a broad COPD population. “So being able to reduce those mucus plugs, we expect, is an important part of driving benefit for patients who are living with COPD,” Barr said. Again touching on the breadth of the study populations, Barr added that tozorakimab “worked across all eosinophil levels in both current and former smokers across all levels of lung function,” which she suggested “really simplifies decision-making for clinicians, and it allows them to offer therapy to the broadest possible patient population.” In the highest patient eosinophil count group, tozorakimab helped chart a 43% reduction in exacerbation risk, which Barr stressed were “unprecedented data.” In the mid-level group, AZ’s drug delivered a 23% reduction and, in the lowest group, a 34% reduction in eosinophils, which Barr said suggests efficacy “in all patient subgroups.” As for AZ’s recent guidance upgrade on the medicine’s sales opportunity, the lift from a $3 billion to $5 billion range to $5 billion plus was informed by multiple factors, Barr said, including the fact that “in 2024, there were multiple competitors, and there aren’t anymore.” Additionally, “we know that this is a massive unmet medical need, and this is a really incredible set of data that we think will be very convincing to the clinical community,” Barr said. Looking ahead to a potential evolution of the COPD treatment landscape, Barr noted that most patients start treatment in the community with an option like a triple therapy, and for them, having an option like AstraZeneca’s inhaler Breztri will remain a “really important part” of that journey. But of the patients uncontrolled on triple therapy, which Barr described as “about half of them today,” just a “small fraction” are currently eligible for biologic therapy, which she emphasized AstraZeneca is working to change. Understanding that COPD is not a “one-size-fits-all” disease, AstraZeneca is also looking at its antibody drug Tezspire for patients with T2-driven disease, and the company continues to think about new mechanisms for tackling COPD through both systemic and inhaled drugs, Barr said.
NASA Sea Level Science Makes Waves on World Ocean Day
Explore This SectionScienceScience Activation1,000 Museum Visitors Dive… OverviewResourcesOpportunitiesCitizen ScienceHighlightsAbout Science
Dan Stevens and Gabriel Luna are the new killers on the block in season 2 of “Dexter: Resurrection” (exclusive)
Showrunner Clyde Phillips previews the emergence of the two new serial killers, as well as the shocking return of Krysten Ritter.
What to know about this week's Republican midterm convention
The two-night convention will kick off in Dallas on Wednesday
Cyclospora outbreak followed years of declining FDA foreign inspections
FDA inspections of foreign food sites are down nearly 35% since 2019, according to agency records reviewed by The Associated Press
Preview: Eagles travel to Mainz
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Ashley St. Clair and Alex Gibney on AI and the dangers of Elon Musk
A new documentary about Elon Musk uses an AI avatar to simulate an interview with him, using real quotes | KNSS Radio
Ashley St. Clair and Alex Gibney on AI and the dangers of Elon Musk
A new documentary about Elon Musk uses an AI avatar to simulate an interview with him, using real quotes.
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Six decades of politics (but little government)
The first aired episode of “Star Trek,” entitled “The Man Trap,” premiered on September 8, 1966 — 60 years ago today. I’m actually editing a political science fiction issue of The Forum right now, and it’s prompted to me think a lot about the ways that Trek deals with politics and government and what it’s offered us as commentary. The @smotus report is a reader-supported publication. To support this work, please become a paid subscriber. Subscribe The original TV series ran from 1966 to 1969. It had a loyal but modest following, but the audience grew substantially with the series in syndication for years after that. The franchise developed its first motion picture in 1979, followed by five sequels, and then a whole other series of films built around the “Next Generation” series that first aired in 1987. In recent decades, several more TV series have built up around it, including the current “Strange New Worlds,” now in its fourth season. Throughout the past six decades, the franchise has offered us a good many insights into US politics and international relations, although often disguised as science fiction yarns. The original series was largely a Cold War fable, with the United Federation of Planets (a stand-in for the US) perpetually at odds with the Klingon Empire (a stand-in for the USSR). The “Let That Be Your Last Battlefield” episode (1969) posited a planet divided into two races, largely indistinguishable to outsiders, but nonetheless constituting a brutal racial hierarchy. “Patterns of Force” (1968) showed a struggling planet where the leader had attempted to construct a benevolent dictatorship — literally Nazism without bigotry — and found that authoritarianism could not exist apart from hierarchy and oppression. (Relatedly, I’d put “Star Trek VI: The Undiscovered Country,” high on a list of dad films about the end of the Cold War, near “The Hunt for Red October.”) Get 20% off for 1 year Indeed, the original series itself was something of a political statement, with a multi-racial crew running the Enterprise, a diverse and largely peaceful Federation mostly free from want and oppression, and protected by Starfleet, an armed force whose scientific mission was at least as important as its military one. Famously, when Nichelle Nichols wanted to walk away from the role of Uhura on the original series, none other than Martin Luther King, Jr. met with her and urged her to remain on the show, discussing the importance of viewers seeing an intelligent Black woman as part of the command team three centuries hence. Later series in the Trek franchise offered a good deal of political commentary on their own, but probably none as explicitly and incisively as “Deep Space Nine,” which ran from 1993 to 1999. The episodes surrounding the Dominion War, especially the “In The Pale Moonlight” (1998), showed the compromises, sacrifices, and moral rot associated with winning even a just war — probably better than any series would until “Andor” (2022-25). In “Far Beyond The Stars” (1998), Captain Benjamin Sisko is somehow transplanted to the role of a science fiction writer in 1950s New York. The writer is frequently sidelined and his ideas stolen because publishers don’t want to credit a Black writer. Several series have depicted the secretive Section 31 — an unacknowledged black ops security force operating within Starfleet. These episodes often end up using Section 31 as a foil to show the dangers of a lawless group within a lawful society, even (especially) when that group posits itself as essential for everyone else’s freedom to continue. The current “Strange New Worlds” has played with a few political themes. I found the first two seasons of this show among the best that the Trek franchise has produced in decades, but this season and the last have really been struggling for ideas. Yet one interesting thread is the idea that the diplomatic and enlightened leadership style of Captain Christopher Pike will not work in all situations. “A Quality of Mercy” (2022), which I wrote about here, puts Pike in the middle of a battle with a Romulan vessel in an alternate timeline, and finds that Pike’s conciliatory style would actually make a lengthy and deadly war more likely, while a quick and more violent approach might have prevented the war. This season’s opener, “Valles Marineris,” shows a pre-lightspeed civilization locked in a war to the death with a neighboring planet. The idea of an alliance or a federation hasn’t even occurred to them — their ship’s commander is curious but doesn’t see it as an option. For a franchise as political as “Star Trek,” one thing we almost never see is the government. We get occasional glimpses of Starfleet’s council — mostly uniformed people at a rectangular table — but almost no sense of how the Federation is governed. Are there elections? Who is in the legislature? How much power does the president have? What kind of factional divisions do they wrestle with and how? The shows and films are pretty silent on this. We’ve seen a few military tribunals within Starfleet, but little about how civilians deal with crime and injustice. With recent years seeing some of the franchise’s more interesting plot lines and casts, it seems clear that Star Trek is still full of energy and ideas. Given the erosion of American democracy and the reshuffling of the international order, there’s no shortage of material for future shows to comment on. I’m not sure we should toast to 60 more years, but cheers to a show that continues to teach us about ourselves. Share
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MDI Health to Honor Mount Desert Nursing Association with 2026 Impact Award
BAR HARBOR—MDI Health will honor Mount Desert Nursing Association (MDNA) as its 2026 Community Partner of the Year during the organization’s Annual Meeting and Community Celebration on Tuesday, September 15. MDNA will receive the 2026 Impact Award in recognition of its longstanding commitment to providing in-home nursing, physical and occupational therapy, and medical equipment to the Island region. By caring for people where they live, MDNA helps patients remain safely and independently at home, providing reassurance and support to their families. “Mount Desert Nursing Association exemplifies the power of community partnership,” said Chrissi Maguire, President and CEO of MDI Health. “Its nurses bring skilled, compassionate care directly into people’s homes, helping patients navigate illness, recovery, and some of life’s most difficult moments. We are deeply grateful for MDNA’s service and the important role it plays in the health of our community.” MDNA works closely with MDI Health providers and care teams to support continuity of care following hospitalization, surgery, illness, or changes in health. Its personalized services extend care beyond the hospital and help ensure patients receive the support they need close to home. “For 77 years, MDNA has been here for our community, helping our neighbors recover and remain safely at home. Our long-standing partnership with MDI Health is an important part of making that possible. Together, we help ensure a seamless transition from hospital to home and provide patients with the continued care they need. We are incredibly grateful for this recognition and especially proud of our talented and hardworking team,” said Amy McVety, Executive Director of Mount Desert Nursing Association. The Impact Award will be presented during MDI Health’s Community Celebration from 5 to 7 p.m. at the Bar Harbor Club. The event will also recognize outstanding employees, volunteers, and trustees; celebrate MDI Health’s achievements over the past year; and mark a transition in Board leadership as Madeleine Braun, PhD, MBA, prepares to succeed Martha Wagner, PhD, as chair. The celebration will feature music, refreshments, the MDI Health Auxiliary Raffle, and a cash bar. MDI Health’s Annual Business Meeting will take place from 3:30 to 4 p.m. via Zoom. These events are free and open to the public, but space is limited. To reserve your spot, contact Patrianna Anderson at 207-288-5082, ext. 1432, or visit mdihospital.org/communitycelebration. Subscribe Share Leave a comment
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