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The set-pieces: Real Madrid 2-1 Inter
Madrid won the first contact from two of their seven deliveries and generated four shots, three of them in the second phase
Washington’s Deuce Davis Continues Havoc at EDGE
Sunday afternoon saw the first reps that Russell "Deuce" Davis II has taken since his three-sack performance in the UCLA game of 2024. That year, he played just 34 defensive snaps before injuries sidelined him for all of 2025. In the Apple Cup, Davis recorded a sack on his first play back. He appeared on …
Midwest Aerial Athletics wins big in Aruba
SIOUX FALLS, S.D. (KELO) —KELOLAND News first took you to Midwest Aerial Athletics back in July. The gym was gearing up to compete on the international stage. “We just competed in Texas, and that was the qualifier for Aruba. So we’re going to Aruba this year and hopefully Australia and then Italy in the next […]
Free classes offer first aid skills for mental health
Astra Mental Health and Recovery has free community Mental Health First Aid classes coming up Sep. 10 and Sept. 23.
Free classes offer first aid skills for mental health
Astra Mental Health and Recovery has free community Mental Health First Aid classes coming up Sep. 10 and Sept. 23.
Colts Part Ways With 29-Game Starter
Jaylon Jones did well to turn himself from a seventh-round pick into a consistent contributor the Indianapolis Colts. Those contributions didn’t end up being big enough, though. The Colts waived Jones on Tuesday. It was part of a three-pronged roster move that the Colts announced in an official press release like this: “The Indianapolis Colts […] The post Colts Part Ways With 29-Game Starter appeared first on HEAVY.
Severe Warning Issued Over Technique Putting Patrick Mahomes at Risk
The Kansas City Chiefs fans are still not completely certain whether Patrick Mahomes will be starting in the season’s opening Week 1 game. The team suffered heavily last season when the quarterback suffered an ACL injury that has kept him out for a long time. He has missed the entire offseason, including the preseason games. […] The post Severe Warning Issued Over Technique Putting Patrick Mahomes at Risk appeared first on Gridiron Heroics.
Browns news: Deshaun Watson a team captain for Week 1
The Cleveland Browns and head coach Todd Monken have opted to deploy captains on a week-to-week basis this year, rather than instill season-long captains. The team is young and still trying to figure things out, and Monken believes there are more leaders on the team than just five. Monken will name two offensive, two defensive, and one special […] The post Browns news: Deshaun Watson a team captain for Week 1 appeared first on ClutchPoints.
Flyers Confirm Major New Arena News
After nearly three decades of playing at the historic Spectrum in South Philadelphia, the Philadelphia Flyers and 76ers moved into Xfinity Mobile Arena (originally called CoreStates Center) in 1996.The upcoming campaign will the be 30th season that both teams call the venue home, but that won’t be the case much longer. Renderings have been released […] The post Flyers Confirm Major New Arena News appeared first on HEAVY.
Andy Reid Officially Confirms Patrick Mahomes’ Week 1 Status
It has seemed like a forgone conclusion that Patrick Mahomes will start at quarterback for the Kansas City Chiefs Week 1, but it has not been set it stone. That changed on Tuesday when coach Andy Reid spoke to the media and officially confirmed that Mahomes will play Week 1 against the Denver Broncos on […] The post Andy Reid Officially Confirms Patrick Mahomes’ Week 1 Status appeared first on HEAVY.
Local businesses brace for gigantic cargo moves starting next week
Locals anxiously waiting for superloads of heavy equipment — weighing up to 380 tons — to travel through their towns will have to hold on until next week. The first trip, on a giant, specialized truck, is expected to leave a dock in Gilpin’s Schenley section on Monday morning. Officials
Villa take 'big step forward' with win over Brugge
Unai Emery said Aston Villa took "one big step forward" after clinching their first win this season with a 3-2 victory at Club Brugge in their Champions League opener on Tuesday."We took one step forward today and it was very, very important for our confidence and stability," Emery said.
Louisville opens first mental health crisis center
Louisville’s first mental health crisis center is now open, offering walk-in help and a new option beyond jail or the emergency room.
49ers Predicted to Bring Back $88 Million Super Bowl Champion
The Athletic's Matt Barrows predicts the San Francisco 49ers will bring back an $88 million edge rusher. The post 49ers Predicted to Bring Back $88 Million Super Bowl Champion appeared first on HEAVY.
Rams Reveal Aaron Donald’s Status for Season Opener in Australia
The Los Angeles Rams have made a decision as to whether star defensive lineman Aaron Donald will play in the season opener in Australia. The post Rams Reveal Aaron Donald’s Status for Season Opener in Australia appeared first on LA Sports Report.
❌ Sent off after provocation: E. Mbappé loses his head
In the first leg between Lille and Real Betis, Ethan Mbappé initially shone with an assist for the opening goal. After that, however, things only went according to plan to a limited extent for the Fr...
Jake Gyllenhaal sees a spooky Phoebe Dynevor in first look at M. Night Shyamalan and Nicholas Sparks’ ‘Remain’
Jake Gyllenhaal and Phoebe Dynevor star in the trailer for ‘Remain,’ based on the supernatural romance co-written by M. Night Shyamalan and Nicholas Sparks.
Porto vs Manchester City Match: Champions League Live Updates
Porto hosts Manchester City at the Estádio do Dragão on Tuesday, September 8, in the opening round of the 2026-27 UEFA Champions League phase. Both teams enter the European opener in strong domestic form and will be looking to start their Champions League campaigns with a positive result. Kickoff is scheduled for 8 p.m. BST, […] The post Porto vs Manchester City Match: Champions League Live Updates appeared first on HEAVY.
Nebraska Stat Tracker vs Ohio, Week 1
Nebraska 49, Ohio 21 — and the offense is a long way ahead of the defense Welcome to the first statistical breakdown of the 2026 Nebraska football season. I said back in the summer that I’d track a set of numbers all year to see how this team is actually doing, and this is the […]
Trump Tells Weird Lie About Where He Was on 9/11
At an event honoring first responders, Trump claimed he was carried away from Ground Zero by firefighters, which didn’t happen.
Cowboys’ $113 Million Edge Rusher Predicted for Career Breakthrough
The Athletic's Jon Machota predicts $113 million Dallas Cowboys edge rusher on verge of career breakthrough. The post Cowboys’ $113 Million Edge Rusher Predicted for Career Breakthrough appeared first on HEAVY.
Alim McNeill Lands Bold Pro Bowl Prediction From The Athletic
The Athletic predicts Alim McNeill makes his first Pro Bowl for the Lions in 2026. #Lions
Exclusive: Two of gaming’s biggest names are making a big investment in gaming’s future
The first thing to know about the Nova Games Foundation is that it isn’t about The Game Awards. And it’s not about PlayStation. The ambitious new grant program is the brainchild of Geoff Keighley and Mark Cerny. Keighley is the host of The Game Awards, Summer Game Fest and Opening Night Live. Cerny is a game designer of some 45 years and the lead architect for the PlayStation 4 and 5. But this new thing, which they’re revealing through Game File, isn’t about their day jobs. It’s an unaffiliated, standalone philanthropic project. It’s a bet on the artistic future of video games and a way, they tell me, to give back. “I’m nearing the end of my career,” Cerny recently told me over email. “I’m not done yet, but paying it forward—in the best way possible—is very much on my mind these days,” The Nova Games Foundation is a university-affiliated fellowship program, intended to offer six-figure grants to 20 young game designers each year, potentially for decades to come. It will offer no-strings-attached funding along with mentorship from games industry leaders, a combination intended to aid the development of groundbreaking new games, Cerny and Keighley told me. Nova will begin accepting applications in December, from class of 2026 and 2027 students from 13 affiliated gaming programs at universities in eight countries. The schools working with Nova include the New York University and the University of Southern California in the U.S., along with Abertay University in Scotland, Cnam-Enjmin in France, TH Köln in Germany, and the Royal Melbourne Institute of Technology in Australia, Cerny and Keighley said. The plan: $100,000 per recipient, with about a quarter of Nova fellows eligible for up to $500,000 more for projects that are shaping up particularly well. Payments will be delivered based on development milestones, and recipients will own their games. Nova will help promote the work, and developers will be free to pursue the publishers and platforms of their choice. Nova can help introduce fellows to publishers, but won’t take a cut. “I’ve always wanted to give back, but given my role in the industry, I’ve never felt it appropriate to commercially invest in games,” Keighley told Game File. “I’ve never owned stock in a game company or taken a financial stake in a game. Nova is philanthropy: we aren’t taking equity or looking to recoup the grants. The return we’re hoping for is creative—helping new voices make games and find their footing. “Mark and I have each made multi-million-dollar donations to establish the foundation, and we intend to keep contributing. We hope others will join us.” Cerny and Keighley have already hired an executive director, John Maconga, and a head of grants, recent Game Developers Conference director Ashley Corrigan, to help launch the effort. They’re working to recruit game industry leaders to join the effort. Keighley says “dozens of leading game directors have already expressed interest in contributing their time.” To name one, they’ve already gotten Josef Fares, lead designer from It Takes Two and Spit Fiction studio Hazelight on board with a donation and pledge to help out. “I’m proud to support Nova because it gives the next generation of creators the freedom to explore their creativity and hopefully bring their unique visions to life,” Fares told Game File. A plan forged from a friendship Keighley and Cerny have known each other a long time. It’s been so long, Cerny isn’t even sure exactly when they met. “We travel in much the same circles and I’m sure first intersected in the 90s or early 2000s,“ Cerny said. Keighley thinks it might have been during his stint writing a column about the mid-’90s console 3DO for a gaming magazine while Cerny was working on games with Crystal Dynamics or on Way of the Warrior with Naughty Dog. They became genuine friends about a 10 years ago, Keighley said, as they bonded over a shared love of games and a hope to improve the industry. “About a decade ago, we started having dinner a few times a year in LA,” Keighley said. “Just to catch up on life and the industry. Those conversations continued over Zoom during COVID. Nova grew out of that friendship and a question we kept coming back to: ‘What could we do to help the next generation of game directors get started?’” Keighley credits Cerny with the idea to figure out a way to put their money and time back into the industry. At one of those dinners, Keighley proposed the idea of a fellowship program. He’d recalled applying for a Rhodes Scholarship when he was younger. “Spoiler: I didn’t get it,” he said. He’d admired the MacArthur Foundation’s so-called “genius grants.” He liked these kinds of programs that recognized people’s talents and gave them the financial boost and the freedom to realize their potential. With Cerny, he had pondered what a game industry version of that could be. Keighley liked the idea of centering the fellowship on students, drawing inspiration from the accomplishments of Jenova Chen, the USC game design graduate who went on to lead the creation of gently moving, ambitious games such as Flower and Journey. Keighley also thought it could be useful to help promising graduates bridge the transition from student to professional. “Joining an established studio isn’t always possible—especially in today’s market—and even then, it isn’t the right path for everyone,” Keighley said. A fellowship, he realized, could give “graduates the time, resources and guidance to pursue a game of their own and not worry about the commercial viability.” As the idea took shape, Cerny also saw an opportunity to enable more games of a certain type: “The target with the grants is games as an artistic medium,” Cerny told me. “We like to say games with ‘artistic, literary and societal value.’” He added: “I’m a pretty big gamer myself, though I tend to gravitate towards the smaller and more unique or artistic titles, games like Neva, Abzu, Gorogoa, Stray or Outer Wilds. I was just playing and Roger on a flight to Japan, and was getting misty eyed to a degree that I was concerned that a flight attendant would ask me if I was OK. “So one fun benefit here is the games that will come out of the Nova Games Foundation – I can’t wait to play them myself.” Cerny believes it will also be useful for Nova fellows to hone their craft and team leadership skills. “We are looking for the next generation of visionaries,” he said. “The trick is that they will also need to have the executive function necessary to drive a small project to completion.” Game File is a reader-supported publication. To receive new posts and support my reporting, please consider becoming a free or paid subscriber. Subscribe Going big with this Keighley and Cerny may have started Nova and may be the ones primarily backing it right now, but they’re dreaming of something that goes beyond them. “Mark and I may have helped get it started, but one of our measures of success is that Nova grows into something the entire games industry feels a sense of ownership in,” Keighley said. “Our ambition is to build a lasting endowment supported by people and companies across the industry, and an equally broad community of creators willing to give their time and experience to the next generation.” The industry has a lot of knowledge that it can pass to the next generation, Keighley said: “Nova can hopefully become a way to connect that generosity with talented young creators at the moment when it can make the biggest difference.” Cerny, who told me he believes Nova can mature “over the next 10 or 20 years,” sees an opportunity to give generations of game makers momentum. “The industry has changed immeasurably since I started in games in 1982,” he said. “These graduates have talent, training and tools that outclass what we had back in the day by an astonishing amount. But they face a tough road ahead getting traction in the industry, and many could benefit from our support. We want to be there to give it to them.” “There’s a personal side to this, too,” Keighley said. “I don’t have children, and I’ve spent a lot of time thinking about what I can do for future generations. Games have been my entire career. I’ve been incredibly fortunate, and helping someone else build a life in this industry feels like a meaningful way to give back.” Cerny’s oeuvre dates back to Marble Madness and Sonic the Hedgehog 2. He has stood on stage multiple times to reveal the future of PlayStation hardware. He’s been an executive producer for a string of modern PlayStation classics such as The Last Guardian and Marvel’s Spider-Man. Nevertheless, of Nova, he said, “It’s certainly not like anything I’ve done before.” Nova Foundation applications will be due in December and the first wave of fellows will be announced in March 2027. A full list of participating universities and steps students and recent graduates can take to apply to become a Nova Fellow is forthcoming.
Sonos just launched ‘Sonos 27’ app update, here’s what’s new
Last week Sonos unveiled several new features coming soon, and now the first of those upgrades are here in the ‘Sonos 27’ app update.
Superior Health Foundation awards $271K to 11 UP health initiatives
Among the recipients are the U.P. Health Impact Grant to Upper Great Lakes Family Health Center’s Sawyer Dental Project, four additional U.P. Health Impact Grants and six Equipment Grants addressing behavioral health/SUD, healthy food and wellness, maternal/infant health, accessibility, EMS/first aid and hospice.
Berman campaign: “We’re going fishing” – ER nurse and Democrat Mitchell Berman launches first ad of general election in Wisconsin’s First District Congressional race
Spot features Berman fishing and focuses on ending corruption in Washington, contrasting Berman’s working class background and Republican Bryan Steil’s corporate special interests RAYMOND, Wis. — Today, Mitchell Berman, ER nurse and Democratic candidate for Wisconsin’s First Congressional District, launched...
Summerfest announces 1st 2027 headliner: Zac Brown Band
MILWAUKEE (WKOW) -- The organizers of Summerfest announced the music festival's first headliner for 2027: Zac Brown Band.
Creators Mean Business: Why This Growing Buyer Community Matters and What Exhibitors Need to Know
In this Exhibitor Town Hall, members of the NAB Show Creator Council share firsthand insights into how creators discover and evaluate technology.
DHR Health and RGV College Honor First-of-Its-Kind Nurse Apprenticeship Class
DHR Health and RGV College came together to celebrate the fifth co-hort of 10 graduates who completed the Registered Nurse Apprenticeship program.
Joe Ryan Reflects On First Start Back From Injury
Although the 30-year-old right-hander was charged with the loss on Monday, he appears to be finding his rhythm again on the mound.
DHR Health and RGV College Honor First-of-Its-Kind Nurse Apprenticeship Class
DHR Health and RGV College came together to celebrate the fifth co-hort of 10 graduates who completed the Registered Nurse Apprenticeship program.
Armor Health Names Regional VP of Client Relations
National correctional healthcare provider Armor Health has appointed Tamara Taylor, RN, CCHP as the company’s first Regional Vice President of Client Relations.
Trump honors 9/11 first responders — and plugs his political priorities
President Donald Trump on Tuesday honored the heroes of the September 11, 2001, terror attacks — but couldn’t resist mentioning the Iran war and communism.
Florida State's Mike Norvell getting booed is nasty business
Things aren’t going well right now for Florida State football head coach Mike Norvell . Not only did his team lose a game on Monday to SMU, but Norvell is also getting booed by fans . “They just played a video of Mike Norvell announcing that the Marching Chiefs would be in the Macy’s Thanksgiving parade. The crowd booed Norvell. (It did cheer for […] The post Florida State's Mike Norvell getting booed is nasty business appeared first on ClutchPoints.
Florida State's Mike Norvell getting booed is nasty business
Things aren’t going well right now for Florida State football head coach Mike Norvell . Not only did his team lose a game on Monday to SMU, but Norvell is also getting booed by fans . “They just played a video of Mike Norvell announcing that the Marching Chiefs would be in the Macy’s Thanksgiving parade. The crowd booed Norvell. (It did cheer for […] The post Florida State's Mike Norvell getting booed is nasty business appeared first on ClutchPoints.
Pirates’ historic slump signals better days ahead
Pittsburgh’s offense dropped from first to worst in second half of 2026
Louisiana contestant wins first runner-up in Miss America, 'Words that will never seem real.'
After reaching the final five, the current Miss Louisiana came up just shy of the win, but grateful for the experience nonetheless.
Apple Event Tomorrow: iPhone 18 Pro and iPhone Ultra Cheat Sheet
Apple's biggest event of the year is almost here, and all eyes are on Cupertino. With the first foldable iPhone expected to headline Apple's "Surprise and Shine" event on Wednesday, September 9, at 10:00 a.m. Pacific Time, the rumor mill has been running full throttle, fuelled by the biggest single design change in the life of the iPhone.
Emmet Sheehan made the most of his return
Emmet Sheehan had such a successful first start back with the Dodgers that he earned at least another, after striking out 10 Cincinnati Reds in Monday night’s win at Dodger Stadium, his first start in the majors in five weeks. “There was a lot of stuff going down, and try to figure stuff out in […]
Andrew Garfield stars as Sam Altman in ominous first look at the controversial “Artificial”
Luca Guadagnino’s upcoming film was dropped by Amazon in June.
Growing girls sports in South Dakota
SIOUX FALLS, S.D. (KELO) — The visibility of volleyball and women’s basketball is only growing in South Dakota. South Dakota State hosted Sioux Falls native Bergen Reilly and volleyball powerhouse Nebraska on Sept. 2. It was the highest attended event in First Bank and Trust Arena’s history. The Sanford Pentagon sold out the state’s first […]
Health: The Fight For The Health Of 9/11 First Responders
A quarter century after 9/11, the health of those who responded to the attacks continues to be affected.Some 3,000 people died across three locations that day. An estimated 400,000 people were exposed to toxic contaminants and risked physical injury in the hours and days that followed. That’s according to data from the Centers for Disease Control and Prevention.Since the dust and debris have settled, more than 96,000 have been diagnosed with physical and mental health conditions related to 9/11.In 2010, President Barack Obama signed the James Zadroga 9/11 Health and Compensation Act, establishing the World Trade Center Health Program and reopening the 9/11 Victims Compensation Fund. Today, more than 150,000 people are enrolled in the program.But that program wouldn’t exist without the advocacy of survivors and first responders who put their bodies and lives on the line following the attacks. How did that fight for care unfold?For more information about the Rutgers WTC Health Program, click here. And to learn more about applying, click here.Find more of our programs online. Listen to 1A sponsor-free by signing up for 1A+ at plus.npr.org/the1a.
Atlanta Braves Announce Pitcher News Before Rays Series
After splitting their four-game series with the Philadelphia Phillies, the Atlanta Braves remain 4.0 games up in the NL East. No off day for Atlanta, as they head home to face the AL East-leading Tampa Bay Rays in a new series this week. It’s another big litmus test for the Braves, as the series’ on […] The post Atlanta Braves Announce Pitcher News Before Rays Series appeared first on HEAVY.
Apple Event 2026 Live: The First Foldable iPhone, iPhone 18 Pro, Apple Watch 12 and More
We're counting down to Apple's Sept. 9 unveiling of the foldable iPhone Ultra. It's the first keynote helmed by new Apple CEO John Ternus and expected to be Apple's biggest event in years.
Cowboys Predicted to Add Champion George Pickens Replacement
The Dallas Cowboys could have a high-scoring offense with George Pickens back. But assuming he leaves after this year, could a college star replace him? The post Cowboys Predicted to Add Champion George Pickens Replacement appeared first on HEAVY.
Devers Records Giants First 35/35 Season Since 2002
Rafael Devers joins Jeff Kent in the San Francisco Giants franchise record books, leveraging an explosive September power surge to make up for the team's horrific season.
Greg Schiano Announces AJ Surace Will Start vs. Boston College
Surace will make his first career start on Friday night.
Apple Falls Before Ternus's First $54 Billion iPhone Test
Tomorrow's launch must turn premium hardware into evidence that Apple can close its AI gap.
NYC releases 170,000 pages of long-sought 9/11 health, air quality records
New York City opened a public portal containing 170,000 pages of 9/11 records sought for years by first responders, survivors and families concerned about Ground Zero health risks
Carole Radziwill says ‘the emotions all came back’ when “Love Story” aired while she filmed her return to “RHONY”
Radziwill is related to John F. Kennedy Jr. through marriage; her late husband, Anthony Radziwill, and JFK Jr. were first cousins.
Appleton West football the focus on Varsity Roundtable
The Terrors are off to their first 3-0 start since 2004. Team members join us on tonight’s Varsity Roundtable.
Smithsonian secretary Lonnie Bunch is leaving amid fights with Trump
Bunch, the first African American and first historian to lead the institution, said he has ‘mixed emotions’ about departing.
SSO to open season with guest conductor
The Southwest Symphony Orchestra (SSO) will present its first concert this season “Inspiration” on Sunday, Sept. 27, at 4 p.m., at Mother McAuley High School, 3737 W. 99th St.
Former Nebraska men’s basketball guard goes pro in Hungary
Former Nebraska men’s basketball guard Jamarques Lawrence has signed with NKA Universitas Pecs, a first-division team in Hungary.
Hogged Rock Curling Fun in KW
Forget his recent griping; Mike enjoyed his first ’spiel of the season
NYC releases 170,000 pages of long-sought 9/11 health, air quality records
New York City opened a public portal containing 170,000 pages of 9/11 records sought for years by first responders, survivors and families concerned about Ground Zero health risks
Chinese giants Xiaomi, Huawei race to get ahead of Apple’s rumored foldable iPhone
Xiaomi and Huawei launched new foldables ahead of Apple’s event, where the company is rumored to unveil its first foldable iPhone.
Dan Campbell Reveals Detroit Lions Guard Plan for Week 1
Dan Campbell is keeping Detroit's left guard competition alive entering Week 1. Christian Mahogany and Ben Bartch will split first-team practice reps, and both could see action against New Orleans.
Amazon Is Taking Preorder Requests for Pokémon TCG 30th Celebration ETBs Well Below Market Price, Marking a Rare First for US Collectors
Amazon US is accepting invite requests for Pokémon TCG 30th Celebration ETBs at $89.99—roughly $90 below market resale value on TCGplayer.
Celebrating 19 Years of Impact from One Iconic Desk
For nearly two decades, Administrative Assistant Carolina Rodriguez has been one of the first faces people see and one they remember at South Texas College’s (STC) Mid-Valley Campus. Long before titles or job descriptions, she became something harder to define but easy to feel: a constant presence, a listening ear and the heart of the campus.
David Oyelowo is the first Black Long John Silver in exclusive ‘Treasure Island’ first look
David Oyelowo was excited to be the first Black actor to play Long John Silver in an adaptation of ‘Treasure Island’: ‘You almost never see that on screen.’
Deonte Banks' ex-coach: 'Everbody's gonna see' why Giants drafted him
Henry Baker, the former coach of New York Giants CB Deonte Banks, believes everyone is about to see why he was a first-round pick.
AZ's R&D chief Barr touts internal 'science success story' after IL-33 antibody's stellar showing in COPD
With a detailed data drop that AstraZeneca’s R&D chief described as an internal “science success story,” the British Big Pharma has secured an FDA priority review for what it believes could become a flagship biologic in chronic obstructive pulmonary disease (COPD). In detailed results from the late-stage Oberon and Titania trials—first teased in March and detailed in full at the European Respiratory Society Congress in Barcelona this week—the drugmaker laid out the extent of its IL-33 inhibitor’s potential to reduce moderate and severe exacerbations in a wide range of COPD patients still struggling with those “lung attacks,” as AstraZeneca’s Sharon Barr, Ph.D., called them, despite using standard-care inhaled therapy. In the headline results, a 300 mg dose of tozorakimab given once every four weeks curbed those moderate and severe exacerbations in the studies’ primary population of former smokers by 29% in the Oberon study and 34% in Titania. In the overall population of both current and former smokers, these reductions were 30% and 29%, respectively, versus placebo and inhaled standard of care. The benefits also extended to clinically meaningful exacerbation reductions in all prespecified patient subgroups and specifically turned up promising signals in patients across a range of blood eosinophil counts, with Barr telling Fierce that “it’s the details that make this even more exciting than the high-level results that we’ve already shared.” In fact, during AZ’s tozorakimab poster presentation at the ERS 2026 Congress this past weekend, attendees were so enamored by the data that event organizers had to encourage people to clear the room and look at the other presentations on offer, Barr said in an interview. “I think it really speaks to the fact that there is a lot of buzz around these data because the entire respiratory community has been so desperate for new therapies for these patients,” she explained. The respiratory disease continues to represent a “staggering unmet medical need,” Barr said, highlighting the COPD exacerbations that the Oberon and Titania studies homed in on, which she added carry a greater mortality risk than a heart attack. “When a patient has a severe exacerbation, only about half of them are still alive within three and a half years,” she pointed out. As for tozorakimab specifically, Barr christened the molecule “an AstraZeneca science success story,” harkening several years back to the point at which researchers began to explore IL-33 as a driver of respiratory disease, and COPD in particular. At the same time, “there was still so much that wasn’t understood,” she admitted, highlighting the insight that IL-33 signals through both ST2 and EGFR through the RAGE pathway, a discovery Barr attributed to AstraZeneca's own scientists. Understanding the need to tackle both pathways in COPD—and aware of competitor candidates in the hopper, including one that bound ST2—the company ultimately had to make some “courageous decisions,” Barr said. These included taking a prior COPD molecule offline and going back to the drawing board to reinvent its potential IL-33 label “to make sure that we had a molecule that could block signaling through both arms of the pathway, through both the reduced form and the oxidized form, knowing that we wouldn’t be first, but striving to be best.” “When we put [tozorakimab] into the clinic, we firmly believed that we had a differentiated molecule, and we saw the other molecules blocking just ST2 or partially blocking IL-33, unable to deliver two positive pivotal studies in COPD,” Barr explained. “We kept marching forward because we believed our molecule was differentiated, and now I think we have the clinical validation that supports that.” Ultimately, AstraZeneca finds itself on much better footing these days when it comes to potential biologic rivals to tozorakimab in COPD. Sanofi and Regeneron’s Dupixent, for instance, is approved to treat COPD exacerbations in patients with high eosinophil counts, but not low ones. Meanwhile, the future has become cloudier for other next-gen IL-33 candidates from Sanofi and Regeneron, as well as Roche, which have suffered trial flops in recent years. One other potential ingredient for AstraZeneca’s success in its duo of studies was that the company was “ambitious in the trial design, willing to look at an all-comers population,” Barr said, “and willing to enroll the most severe patients.” Prior studies for would-be biologics rivals in COPD “avoided enrolling” those patients, she pointed out. She also highlighted the Big Pharma’s painstaking design of exacerbations in its trial, which “gave us a very rigorous readout,” and pointed to “the extra effort and investment” the company put in to understand the effect of mucus plugs in patients. Barr described mucus production as a “key feature in disease diversity,” noting that mucus plugs—obstructing clumps of mucus that block patients’ airways—are associated with worse outcomes in COPD. In its data announcement, AstraZeneca noted that an integrated analysis of Oberon and Titania found tozorakimab “demonstrated a reduction in patients’ mucus plug score,” with the pharma claiming its biologic is the first to deliver such results in a broad COPD population. “So being able to reduce those mucus plugs, we expect, is an important part of driving benefit for patients who are living with COPD,” Barr said. Again touching on the breadth of the study populations, Barr added that tozorakimab “worked across all eosinophil levels in both current and former smokers across all levels of lung function,” which she suggested “really simplifies decision-making for clinicians, and it allows them to offer therapy to the broadest possible patient population.” In the highest patient eosinophil count group, tozorakimab helped chart a 43% reduction in exacerbation risk, which Barr stressed were “unprecedented data.” In the mid-level group, AZ’s drug delivered a 23% reduction and, in the lowest group, a 34% reduction in eosinophils, which Barr said suggests efficacy “in all patient subgroups.” As for AZ’s recent guidance upgrade on the medicine’s sales opportunity, the lift from a $3 billion to $5 billion range to $5 billion plus was informed by multiple factors, Barr said, including the fact that “in 2024, there were multiple competitors, and there aren’t anymore.” Additionally, “we know that this is a massive unmet medical need, and this is a really incredible set of data that we think will be very convincing to the clinical community,” Barr said. Looking ahead to a potential evolution of the COPD treatment landscape, Barr noted that most patients start treatment in the community with an option like a triple therapy, and for them, having an option like AstraZeneca’s inhaler Breztri will remain a “really important part” of that journey. But of the patients uncontrolled on triple therapy, which Barr described as “about half of them today,” just a “small fraction” are currently eligible for biologic therapy, which she emphasized AstraZeneca is working to change. Understanding that COPD is not a “one-size-fits-all” disease, AstraZeneca is also looking at its antibody drug Tezspire for patients with T2-driven disease, and the company continues to think about new mechanisms for tackling COPD through both systemic and inhaled drugs, Barr said.
Hong Kong students drop in global rankings for maths, science and literacy
City’s students drop out of global 10 in Pisa’s science section – the first time since Hong Kong joined international assessment.
Fantasy Football D/ST Rankings: Week 1 2026
There is plenty of fantasy football speculation running backs . And there are some undervalued tight ends . But people often forget about the defenses. Don’t do it! Pick a good one and stick with it. And here are the fantasy football defense and special teams rankings for Week 1 of the 2026 NFL season. The Week 1 list looks a lot like the usual […] The post Fantasy Football D/ST Rankings: Week 1 2026 appeared first on ClutchPoints.
SC's Emerging Biotech Industry Receives National Recognition
Genetic Engineering & Biotechnology News (GEN) recently named the Palmetto State among its “Regional and State Clusters to Watch” in its first-ever Next 10 U.S. Biopharma Clusters report, highlighting emerging life sciences ecosystems beyond...
Dan Stevens and Gabriel Luna are the new killers on the block in season 2 of ‘Dexter: Resurrection’ (exclusive)
See the exclusive first look at Dan Stevens and Gabriel Luna as the newest serial killers on ‘Dexter: Resurrection,’ as well as the shocking return of Krysten Ritter.
Kit Leak: Germany’s first Nike away kit could be green
Nike turns to German football tradition with a striking green and black colorway for the DFB men's national team.
Adley Rutschman's three-run HR off Pesky Pole carries Red Sox past Angels, 5-2
Adley Rutschman hit a three-run homer off the Pesky Pole in right field, Brayan Bello pitched five scoreless innings in his first start since early June and the hot-again Boston Red Sox beat the Los Angeles Angels 5-2 on Monday afternoon.
First Renderings Of New Philadelphia Arena Inspired By The Spectrum
Planned 2030 opening includes an outdoor plaza and opportunities for an expanded restaurant experience at the South Philadelphia location
1,000 Museum Visitors Dive Into NASA Sea Level Science on World Ocean Day
More than 1,000 visitors explored NASA sea level science firsthand during World Ocean Day at the University of Georgia Aquarium on Skidaway Island on June 6, 2026.
The final season of ‘Yellowjackets’ is not holding back: ‘We get a little crazy’ (exclusive)
They’re being rescued! An exclusive first look at the final season of ‘Yellowjackets’ digs into the aftermath of the wilderness (and Wilderness) as co-creator warns, ‘Buckle up.’
Online cybersecurity clinic available for Hawaiʻi small businesses
“The One-Person Security Department: Building Your Own Tools for Hawaiʻi IT on No Budget” is the topic for the first in a series of three free Zoom meetings presented by the University of Hawaiʻi Maui College for sole proprietors and registered businesses in Hawaiʻi.
I judged people with house cleaners. Hiring one changed my life.
At first, paying someone to clean my house felt bougie. Raising four kids made it a practical decision.
Preview: Eagles travel to Mainz
Eintracht are looking to claim their first league win of the season at 1. FSV Mainz 05. Adi Hütter says his players are still developing, while Mario Götze has called for maximum performance.Backdro...
DeWitt’s Crossroads Business Park gets ready for growth
DEWITT, Iowa – Community leaders and development partners recently celebrated the groundbreaking of five regional water detention ponds in an expansion of the Crossroads Business Park, marking a major milestone in preparing the site for future industrial growth. The project is the first phase of infrastructure improvements that will make approximately 125 acres of development […]
Legal complaint against FIFA to cover impact on women’s schedule
A legal complaint against FIFA has been extended to cover its “abusive conduct” towards the women’s game in Europe. The complaint by the European Leagues umbrella group, which includes the Premier League and Scottish Professional Football League (SPFL) as members, was first lodged with the European Commission in October 2024.
Apple’s new CEO John Ternus expected to debut foldable iPhone at event Wednesday
Apple will kick off a new era on Wednesday when CEO John Ternus takes the stage for the first time for the company’s annual iPhone launch event.
Kelly Ripa returns to ‘Live’ for first time in over 1 month after painful gum surgery
Kelly Ripa finally returned to ‘Live With Kelly and Mark’ for the first time in over a month, following an extended absence due to painful gum surgery.
How Tottenham beat Leeds to Mudryk
Insight into how Mykhailo Mudryk became the first player to move from Chelsea to Tottenham in 17 years and the first loanee to join Spurs from Chelsea since 1992.
Trust in Jackson crucial for Emery
Ollie Watkins' departure to Al-Hilal - which lurched between acrimonious and emotional - has left Aston Villa without their best attacking outlet. Despite just one goal in his first 13 top-flight games last season, he ended up netting 16, leaving him on 91 Premier League goals - a club record. Nicolas Jackson was brought in as Watkins' direct replacement and was a priority signing for Unai Emery, having worked together at Villarreal.
National GOP to feature Cunningham vs. Vasquez race at midterm convention
Overview: Vasquez criticizes Cunningham for appearing at event after Trump posted of renaming New Mexico "New America" President Donald Trump is headlining a first-ever “Midterm Convention” for the Republican Party this week in Dallas and at least one New Mexico candidate is on the announced agenda. This story was originally published at New Mexico Political […]
Six decades of politics (but little government)
The first aired episode of “Star Trek,” entitled “The Man Trap,” premiered on September 8, 1966 — 60 years ago today. I’m actually editing a political science fiction issue of The Forum right now, and it’s prompted to me think a lot about the ways that Trek deals with politics and government and what it’s offered us as commentary. The @smotus report is a reader-supported publication. To support this work, please become a paid subscriber. Subscribe The original TV series ran from 1966 to 1969. It had a loyal but modest following, but the audience grew substantially with the series in syndication for years after that. The franchise developed its first motion picture in 1979, followed by five sequels, and then a whole other series of films built around the “Next Generation” series that first aired in 1987. In recent decades, several more TV series have built up around it, including the current “Strange New Worlds,” now in its fourth season. Throughout the past six decades, the franchise has offered us a good many insights into US politics and international relations, although often disguised as science fiction yarns. The original series was largely a Cold War fable, with the United Federation of Planets (a stand-in for the US) perpetually at odds with the Klingon Empire (a stand-in for the USSR). The “Let That Be Your Last Battlefield” episode (1969) posited a planet divided into two races, largely indistinguishable to outsiders, but nonetheless constituting a brutal racial hierarchy. “Patterns of Force” (1968) showed a struggling planet where the leader had attempted to construct a benevolent dictatorship — literally Nazism without bigotry — and found that authoritarianism could not exist apart from hierarchy and oppression. (Relatedly, I’d put “Star Trek VI: The Undiscovered Country,” high on a list of dad films about the end of the Cold War, near “The Hunt for Red October.”) Get 20% off for 1 year Indeed, the original series itself was something of a political statement, with a multi-racial crew running the Enterprise, a diverse and largely peaceful Federation mostly free from want and oppression, and protected by Starfleet, an armed force whose scientific mission was at least as important as its military one. Famously, when Nichelle Nichols wanted to walk away from the role of Uhura on the original series, none other than Martin Luther King, Jr. met with her and urged her to remain on the show, discussing the importance of viewers seeing an intelligent Black woman as part of the command team three centuries hence. Later series in the Trek franchise offered a good deal of political commentary on their own, but probably none as explicitly and incisively as “Deep Space Nine,” which ran from 1993 to 1999. The episodes surrounding the Dominion War, especially the “In The Pale Moonlight” (1998), showed the compromises, sacrifices, and moral rot associated with winning even a just war — probably better than any series would until “Andor” (2022-25). In “Far Beyond The Stars” (1998), Captain Benjamin Sisko is somehow transplanted to the role of a science fiction writer in 1950s New York. The writer is frequently sidelined and his ideas stolen because publishers don’t want to credit a Black writer. Several series have depicted the secretive Section 31 — an unacknowledged black ops security force operating within Starfleet. These episodes often end up using Section 31 as a foil to show the dangers of a lawless group within a lawful society, even (especially) when that group posits itself as essential for everyone else’s freedom to continue. The current “Strange New Worlds” has played with a few political themes. I found the first two seasons of this show among the best that the Trek franchise has produced in decades, but this season and the last have really been struggling for ideas. Yet one interesting thread is the idea that the diplomatic and enlightened leadership style of Captain Christopher Pike will not work in all situations. “A Quality of Mercy” (2022), which I wrote about here, puts Pike in the middle of a battle with a Romulan vessel in an alternate timeline, and finds that Pike’s conciliatory style would actually make a lengthy and deadly war more likely, while a quick and more violent approach might have prevented the war. This season’s opener, “Valles Marineris,” shows a pre-lightspeed civilization locked in a war to the death with a neighboring planet. The idea of an alliance or a federation hasn’t even occurred to them — their ship’s commander is curious but doesn’t see it as an option. For a franchise as political as “Star Trek,” one thing we almost never see is the government. We get occasional glimpses of Starfleet’s council — mostly uniformed people at a rectangular table — but almost no sense of how the Federation is governed. Are there elections? Who is in the legislature? How much power does the president have? What kind of factional divisions do they wrestle with and how? The shows and films are pretty silent on this. We’ve seen a few military tribunals within Starfleet, but little about how civilians deal with crime and injustice. With recent years seeing some of the franchise’s more interesting plot lines and casts, it seems clear that Star Trek is still full of energy and ideas. Given the erosion of American democracy and the reshuffling of the international order, there’s no shortage of material for future shows to comment on. I’m not sure we should toast to 60 more years, but cheers to a show that continues to teach us about ourselves. Share
Elvira joins “R.L. Stine’s Pumpkinhead 2” as mysterious witch — See the first look (exclusive)
The Mistress of the Dark, a.k.a. Cassandra Peterson, will play a character named...Cassandra.
Elvira joins ‘R.L. Stine’s Pumpkinhead 2’ as mysterious witch: See the exclusive first look
Elvira joins ‘R.L. Stine’s Pumpkinhead 2’. See the exclusive first look at the Mistress of the Dark as a mysterious witch.
The fight for the health of 9/11 first responders
More than 96,000 have been diagnosed with physical and mental health conditions related to the attacks.
Apple to make first big change to iPhones in years
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Scientists Just Filmed One of the Deep Sea’s Creepiest Creatures for the First Time in This Part of the Pacific
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76ers, Flyers Unveil First Look at New Arena Designed to Shape the Future of Philadelphia Sports and Entertainment
Scheduled to open in 2030, the arena is designed to deliver a next-generation fan experience and amplify the energy of Philadelphia sports, concerts, live entertainment and community programming.
Scientists observe Einstein’s gravity in the quantum world for the first time
Physicists have directly observed a long-predicted quantum effect of gravity, putting one of Einstein’s foundational ideas to a striking new test. Using ultracold atoms, researchers split an atom’s quantum wave so that one part was held in place while the other fell freely under gravity, then reunited the two to measure the tiny difference that emerged.
Nottingham Forest Loan Round-up: Sillah Nets First Goal
A look at how Nottingham Forest's loanees got on over the past week.
Range Sports to feature Baylor, USC women in inaugural Hollywood Hardwood Classic on BTN
The event will mark the first women’s college basketball game at the Clippers’ arena in Inglewood, Calif. Will Funk, Range Sports’ co-President, tells SBJ that the company is already looking at other opportunities in the college realm, as NIL has “created more space to create unique matchups,"
Singapore ministers, among world’s highest paid government officials, get first raise in 15 years
KUALA LUMPUR, Malaysa (AP) — Singapore’s ministers, already among the world's highest paid, are getting a raise for the first time in 15 years, Prime Minister L
Has Arbeloa 'underestimated' the Premier League?
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Disney’s “Aladdin” reveals first woman to play Genie on Broadway — and she’s a famous former“ View” cohost
“Aladdin” in New York City will host the first woman to ever play the Genie in any of the 11 Disney-produced productions of the show around the world.
Borussia Dortmund vs Villarreal – Predicted lineup and team news
Borussia Dortmund will be aiming to stretch their winning run to four matches in a row this season as they welcome Villarreal for their first UEFA Champions League game of the campaign on Tuesday at S...
UEFA Champions League: Tuesday, Sept. 8 Preview and Predictions
The 2026-27 Champions League is finally here. After months of domestic buildup and qualifying drama, the league phase kicks off tonight with a full slate of intriguing openers. New managers, rebuilt squads, and familiar rivalries all collide as Europe’s elite return to the biggest stage. Here are the predictions for all six matches on opening […] The post UEFA Champions League: Tuesday, Sept. 8 Preview and Predictions appeared first on HEAVY.
15 years of our home! Celebrate on Juventus Play
Exactly 15 years ago, Juventus cut the ribbon on its new home. On 8 September 2011, thousands of people, both inside the stadium and watching on television, held their breath as they got their first g...