SCROLL NEWS / DISCOVERY

Search headlines

Find the stories shaping the conversation.

Search mode
Refine results
Active filters Keyword All time

Results for " Dem " 15,816 found 🔀 AI-powered Shuffle

Apple just raised prices on new and older iPhones. Here’s what they cost now.

Apple and other gadget makers have raised prices in part because of the shortages of key components in hot demand by AI companies.

washingtonpost.com logo
Sep 9 • 3:01 PM EDT • Technology • washingtonpost.com
Apple Unveils the iPhone Duo, a Foldable Phone That Costs $1,999

At the company’s annual September product event, Apple also demonstrated its work on artificial intelligence and other new devices.

nytimes.com logo
Sep 9 • 2:47 PM EDT • Technology • nytimes.com
Demirovic the star as Stuttgart stroll to victory vs Viking

On the club’s 133rd birthday, VfB Stuttgart returned to Champions League action on home soil, looking to start their campaign with three points against Norwegian champions Viking FK.Sebastian Hoene�...

sports.yahoo.com logo
Sep 9 • 2:41 PM EDT • Sports • sports.yahoo.com
ATSC 3.0 Wins Engineering, Science & Technology Emmy Award

The National Academy of Television Arts & Sciences will honor ATSC on October 14 with a 2026 Engineering, Science & Technology Emmy Award.

mixonline.com logo
Sep 9 • 2:36 PM EDT • Science • mixonline.com
Political figure and U.S. army veteran Bruce Lunsford dies

Bruce Lunford, a former Democratic gubernatorial and Senate candidate, has passed away.

wbko.com logo
Sep 9 • 1:36 PM EDT • Politics • wbko.com
Pritzker slams Trump — and his GOP midterm convention

Pritzker appeared in Dallas today to offer a Democratic counter-message.

chicagobusiness.com logo
Sep 9 • 1:29 PM EDT • Politics • chicagobusiness.com
Prologis bets on Chicago-area warehouse demand with $100M Minooka project

The move by the nation’s largest owner of industrial real estate is a notable sign that developers and lenders are growing more confident about speculative warehouses after pulling back in recent years.

chicagobusiness.com logo
Sep 9 • 1:16 PM EDT • Business • chicagobusiness.com
Michael Phelps is raising 4 boys. Here's how he helps them navigate 'big emotions'

Amid experts' rising concerns about the “manosphere” and male loneliness epidemic, the Olympic gold medalist has a message to share.

usatoday.com logo
Sep 9 • 1:04 PM EDT • Health • usatoday.com
AG’s office says it lacks authority to investigate Choice Lanes contract

Following top state Dem’s questions over toll lane procurement process, Skrmetti’s office claims it has no jurisdiction

nashvillepost.com logo
Sep 9 • 1:00 PM EDT • Politics • nashvillepost.com
WA’s 26th Legislative District House race tests its political shift

The race for an open House seat in Washington's 26th Legislative District could test whether the district recent shift toward Democrats is enough to flip a seat Republicans have long held.

seattletimes.com logo
Sep 9 • 1:00 PM EDT • Politics • seattletimes.com
Nikki Fried dodges questions about Cynthia Chestnut crossing party lines for Byron Donalds

The FDP leader declined a chance to clear the air about a Democratic defection.

floridapolitics.com logo
Sep 9 • 12:10 PM EDT • Politics • floridapolitics.com
Preserving the Academy of Natural Sciences

Philadelphia's Academy of Natural Sciences is slatted to close at the end of the month. But can the the 200-year-old museum to be saved?

whyy.org logo
Sep 9 • 12:00 PM EDT • Science • whyy.org
September 2026 Apple Event Spoiler-Free Video Stream

Apple's "Surprise and Shine" media event kicks off at 10:00 am Pacific Time today with members of the media in attendance. We know that some MacRumors readers who can't follow the event as it's being broadcast are interested in avoiding all of the announcements and waiting until the event video is available for on-demand viewing so as to experience it without already knowing the outcome.

macrumors.com logo
Sep 9 • 12:00 PM EDT • Technology • macrumors.com
With Sununu vs. Pappas, familiar names will compete in New Hampshire Senate race

Republican John E. Sununu, a former U.S. senator, and Democrat Chris Pappas, a member of the U.S. House, are vying to replace U.S. Sen. Jeanne Shaheen, whose decision not to seek reelection created a cascade of competitive races.

pbs.org logo
Sep 9 • 11:45 AM EDT • Politics • pbs.org
Academy Sports + Outdoors raises annual profit forecast on cost discipline, e-commerce growth

Academy Sports + Outdoors (NASDAQ:ASO) on Wednesday raised its full-year adjusted profit forecast after posting second-quarter earnings that beat analyst estimates, sending shares up 9%. The sporting goods retailer reported adjusted earnings per share of $2.31 for the quarter, topping...

finance.yahoo.com logo
Sep 9 • 11:12 AM EDT • Sports • finance.yahoo.com
Congressional Report on Potential TBIs, Mental Health Risks in Naval Aviation

The following is “Unseen Impacts: An Investigation into the Navy’s Response to Potential Traumatic Brain Injury and Mental Health Risks in Naval Aviation” published on Sept. 8, 2026, by the House Committee on Oversight and Government Reform Subcommittee on Military and Foreign Affairs. From the Report Executive Summary Following reporting by The New York Times about an epidemic of potential brain injuries in naval aviators contributing to suicide, the House Committee on Oversight and Government Reform launched an investigation to assess the Navy’s knowledge of and actions taken regarding this issue. The findings reveal a disconnect between growing concern and

news.usni.org logo
Sep 9 • 10:48 AM EDT • Health • news.usni.org
Poll shows two-thirds of U.S. Jewish voters will favor Democrats in November

Despite tensions over Israel and rising antisemitism, respondents ranked affordability and the future of democracy as their top issues in the midterms.

jta.org logo
Sep 9 • 10:12 AM EDT • Politics • jta.org
Bruce Willis’ wife says he’s still ‘very present’ in health update amid dementia battle: ‘Learned to adapt’ (exclusive)

EW has an exclusive look inside Emma Heming Willis’ life with Willis, who still has “beautiful moments of joy and connection” amid “terrible” diagnosis.

yahoo.com logo
Sep 9 • 10:00 AM EDT • Entertainment • yahoo.com
Bruce Willis still ‘very present’ amid ‘terrible’ dementia diagnosis (exclusive)

Bruce Willis’ wife, Emma Heming Willis, has given a health update on the actor and how his family ‘learned to adapt’ amid his ‘terrible’ dementia diagnosis: ‘He’s very present.’

ew.com logo
Sep 9 • 10:00 AM EDT • Entertainment • ew.com
Encore Demonstrates Measurable Progress on Responsible Business Priorities

/PRNewswire/ -- Encore, a global leader in event production and technology, today announced the release of its 2026 Responsible Business Report, Illuminating a...

prnewswire.com logo
Sep 9 • 10:00 AM EDT • Business • prnewswire.com
Oregon Democrats seek to calm voters’ election uncertainties

Oregon Democrats express faith in the upcoming vote-by-mail election despite ongoing legal battles over President Donald Trump's attempt to restrict mail ballot delivery.

klcc.org logo
Sep 9 • 9:54 AM EDT • Politics • klcc.org
Suicide-Related ER Visits In Children Rise, But Many Hospitals Lack Specialized Mental Health Care

By Dennis Thompson HealthDay ReporterWEDNESDAY, Sept. 9, 2026 (HealthDay News) — ER visits by children suffering suicide-related crises jumped before and during the COVID-19 pandemic, a new study says. Emergency department visits among children involving self-harm or suicide rose by 74% between 2016 ...

usnews.com logo
Sep 9 • 9:30 AM EDT • Health • usnews.com
The Cost of Cutting American Science: How Federal Cuts Diminish Public Health Capacity

Among the federal government’s many responsibilities is the work it does to protect public health. Federal agencies monitor our food supply to ensure safety, conduct research to better understand emerging health threats, provide funding for public health programs in communities and work to detect and respond to disease outbreaks. Americans rely on these efforts every day—in a 2024 online survey, 74% of respondents said that “if the federal government issued safety guidance about food you eat regularly,” they would follow it. Changes to Federal Public Health Capacity The Trump administration’s efforts to reshape the federal government have resulted in significant impacts on our nation’s public health capacity over the past 20 months, affecting the response to health concerns such as measles, Ebola and cyclosporiasis. Agencies with core public health, food safety and disease prevention responsibilities experienced large workforce decreases during the first year of the administration. At the Centers for Disease Control and Prevention, for instance, the workforce in February 2026 was 26.7% smaller than in September 2024 before the start of the Trump administration. The Food and Drug Administration saw a similarly steep decline of 21.6%. Agencies such as the National Institutes of Health, Substance Abuse and Mental Health Services Administration and Food Safety and Inspection Service also experienced large workforce decreases. (function(){function e(){window.addEventListener(`message`,function(e){if(e.data[`datawrapper-height`]!==void 0){var t=document.querySelectorAll(`iframe`);for(var n in e.data[`datawrapper-height`])for(var r=0,i;i=t[r];r++)if(i.contentWindow===e.source){var a=e.data[`datawrapper-height`][n]+`px`;i.style.height=a}}})}e()})(); Changes can also be seen in crucial public health occupations. The number of federal food inspectors, for example, decreased by more than half between September 2024 and February 2026, going from 1,035 to 473. This is the lowest number of food inspectors employed by the federal government since at least 2005. By February 2026, there were also 33.3% fewer federal public health program specialists, whose work includes advising federal funding recipients on public health activities and analyzing the effectiveness of public health programs. Government’s capacity is diminished as employees with specialized knowledge and experience in protecting the public and responding to health risks depart, leaving agencies less prepared to carry out their public health missions. There also have been vacancies in critical high-level leadership positions at public health agencies, most notably at the CDC, which had a permanent Senate-confirmed director for less than a month between January 2025 and early August 2026. Although the CDC has previously been led by acting directors at the start of an administration, the nearly yearlong gap since the departure of the administration’s first permanent director in August 2025 is without precedent. As of August 2026, the FDA is also currently without a Senate-confirmed commissioner following the previous commissioner’s resignation in May 2026. Additionally, public health agencies are experiencing increased politicization of their leadership ranks. In agencies such as the CDC and Food Safety and Inspection Service, the number of individuals in the Senior Executive Service—the most senior career leaders in government—has declined significantly, while at the same time the number of political appointees has reached record levels. (function(){function e(){window.addEventListener(`message`,function(e){if(e.data[`datawrapper-height`]!==void 0){var t=document.querySelectorAll(`iframe`);for(var n in e.data[`datawrapper-height`])for(var r=0,i;i=t[r];r++)if(i.contentWindow===e.source){var a=e.data[`datawrapper-height`][n]+`px`;i.style.height=a}}})}e()})(); (function(){function e(){window.addEventListener(`message`,function(e){if(e.data[`datawrapper-height`]!==void 0){var t=document.querySelectorAll(`iframe`);for(var n in e.data[`datawrapper-height`])for(var r=0,i;i=t[r];r++)if(i.contentWindow===e.source){var a=e.data[`datawrapper-height`][n]+`px`;i.style.height=a}}})}e()})(); At the CDC, for example, the number of career SES decreased 42.9% between December 2024 and February 2026, while the number of non-Senate confirmed political appointees at the agency was six times larger than the agency’s historical average from 2009 and 2024. Knowledgeable career leaders are integral to the ability of public health agencies to carry out their work with scientific integrity and professional judgment, and rapid leadership turnover and increased politicization threaten agencies’ ability to make evidence-based decisions to protect our health. The upheaval and politicization in public health agencies have also negatively affected employee engagement. Strong employee engagement is crucial to the ability of agencies to carry out their mission and successfully provide essential services to the public. In the 2025 Public Service Viewpoint Survey conducted by the Partnership for Public Service, the Department of Health and Human Services—which encompasses major public health agencies such as the CDC and FDA—had an employee engagement and satisfaction score of 20.4 out of 100, one of the lowest among large agencies. Only 2.8% of HHS employees indicated trust in their political leaders and only 8.7% reported confidence that they could report a suspected violation of law or regulation without retaliation. Employees at HHS also reported that the agency’s ability to provide services to the public had suffered. Nearly half of employees at HHS, 47.5%, said their work unit was worse at delivering quality services compared to its performance in 2024. In addition, 57.8% said their work unit was performing worse at fulfilling stakeholder needs. In addition to the work done within federal agencies, the federal government also distributes significant funding for public health and disease prevention work to state and local governments, nonprofits and small businesses—funding which has been significantly disrupted. At the CDC, for example, there was a 71.9% decrease in the amount of project grant funding issued in fiscal year 2025 compared to fiscal year 2024. The FDA also issued far less funding in fiscal year 2025—a 21.3% decrease from its fiscal year 2024 funding. Changes in federal funding include the ending of grants to community organizations that worked on HIV prevention and the cancellation of funding for research into improvements to patient safety and healthcare quality. These changes go beyond federal agencies to impact the broader public health ecosystem, including the state and local health departments responsible for much of the on-the-ground public health work in their communities. About 80% of the CDC’s domestic funding is directed towards state and local partners—meaning that cuts to CDC funding can ultimately result in cuts to state and local public health capacity. Federal agencies also provide expertise and assistance to state and local health agencies as they deal with particular health challenges, but workforce cuts have resulted in fewer federal employees available to help. The Impact of Changes to Public Health Capacity These changes to federal public health capacity are not abstract concerns. Disrupted programs, reduced funding and lost expertise at public health agencies across all levels of government threaten the public’s physical well-being and safety. In some cases, this has already led to harm. The most immediate impacts of federal cuts were seen in interruptions to ongoing public health programs and crisis responses. In one instance, when CDC grants were canceled during the 2025 Texas measles outbreak—the most severe measles outbreak in 25 years—public health officials in Lubbock, Texas were forced to pause parts of their measles response work supported by the frozen funding. Lubbock’s director of public health further said that a lack of available CDC experts to reach out to for advice “definitely” impacted the department’s response to the measles crisis. Cuts to federal funding also forced Dallas County Health and Human Services to cut staff and cancel 50 community vaccination clinics during the outbreak. Public health work outside of major outbreak responses was also disrupted. For example, in April 2025, the Milwaukee Public Health Department was unexpectedly unable to reach experts on lead poisoning due to firings at the CDC when responding to concerns about lead contamination in Milwaukee public schools. Due to federal workforce cuts, several programs at the CDC, including Alzheimer’s and epilepsy programs, have also become trapped in limbo—existing on paper, but without the staff necessary to operate. More recent crises reveal how federal cuts have weakened the public health infrastructure needed to prevent and respond to dangerous new outbreaks. Internationally, cuts at the U.S. Agency for International Development eliminated funding for disease testing and contact tracing abroad, which delayed detection of and responses to the 2026 Ebola outbreak in the Democratic Republic of Congo. While international outbreaks may seem far removed, the unchecked spread of disease in any country can quickly pose a danger to economic well-being, security and health around the world. Within the United States, public health cuts inhibited responses to the summer 2026 outbreak of the food-borne parasite cyclospora. At the federal level, cuts to funding for lab equipment and for CDC staff with expertise in parasitic infections—including 9 out of 11 staff members at the lab responsible for identifying parasitic outbreaks in 2025— contributed to the largest reporting delay in outbreak cases at the CDC in 15 years. Conflicting communications from the FDA about the source of the outbreak, which followed cuts to the agency’s communications department, additionally led to confusion among the public about how to best avoid infection. At the same time, cuts to HHS funding and support for local and state public health slowed some health departments’ responses to the crisis. The exact costs of these delays, constraints and confusion in public health responses are difficult to estimate. However, their message is clear: federal cuts have already made containing threats to public health even more of a challenge. Conclusion Protecting public health—from food safety to disease prevention—is one of the federal government’s most important missions. Dramatic and haphazard cuts to federal agencies and funding have already disrupted the public health system, impacting the response to challenges such as measles, lead poisoning and cyclosporiasis. The U.S. public health system needed improvement before these disruptions. Since 2022, federal leadership and coordination in response to public health outbreaks has been on the Government Accountability Office’s High-Risk List of areas in need of attention to improve government effectiveness and efficiency. Recent cuts only compound these concerns. The chaotic dismantling of government and resulting disruptions to crucial functions like public health and disease prevention highlight the need for meaningful reform and concrete policy proposals to reimagine how government can better serve the public and be more effective, responsive and accountable. To learn more about the impact of federal cuts to public health and science more broadly, visit The Cost of Cutting American Science. Learn more For more information on the Partnership for Public Service’s government reform initiative, visit Government for a New Era. View here In line with The Cost of Cutting American Science, federal workforce data in this brief is as of February 2026

ourpublicservice.org logo
Sep 9 • 9:00 AM EDT • Science • ourpublicservice.org
The Cost of Cutting American Science: How Federal Cuts Diminish Public Health Capacity

Among the federal government’s many responsibilities is the work it does to protect public health. Federal agencies monitor our food supply to ensure safety, conduct research to better understand emerging health threats, provide funding for public health programs in communities and work to detect and respond to disease outbreaks. Americans rely on these efforts every day—in a 2024 online survey, 74% of respondents said that “if the federal government issued safety guidance about food you eat regularly,” they would follow it. Changes to Federal Public Health Capacity The Trump administration’s efforts to reshape the federal government have resulted in significant impacts on our nation’s public health capacity over the past 20 months, affecting the response to health concerns such as measles, Ebola and cyclosporiasis. Agencies with core public health, food safety and disease prevention responsibilities experienced large workforce decreases during the first year of the administration. At the Centers for Disease Control and Prevention, for instance, the workforce in February 2026 was 26.7% smaller than in September 2024 before the start of the Trump administration. The Food and Drug Administration saw a similarly steep decline of 21.6%. Agencies such as the National Institutes of Health, Substance Abuse and Mental Health Services Administration and Food Safety and Inspection Service also experienced large workforce decreases. (function(){function e(){window.addEventListener(`message`,function(e){if(e.data[`datawrapper-height`]!==void 0){var t=document.querySelectorAll(`iframe`);for(var n in e.data[`datawrapper-height`])for(var r=0,i;i=t[r];r++)if(i.contentWindow===e.source){var a=e.data[`datawrapper-height`][n]+`px`;i.style.height=a}}})}e()})(); Changes can also be seen in crucial public health occupations. The number of federal food inspectors, for example, decreased by more than half between September 2024 and February 2026, going from 1,035 to 473. This is the lowest number of food inspectors employed by the federal government since at least 2005. By February 2026, there were also 33.3% fewer federal public health program specialists, whose work includes advising federal funding recipients on public health activities and analyzing the effectiveness of public health programs. Government’s capacity is diminished as employees with specialized knowledge and experience in protecting the public and responding to health risks depart, leaving agencies less prepared to carry out their public health missions. There also have been vacancies in critical high-level leadership positions at public health agencies, most notably at the CDC, which had a permanent Senate-confirmed director for less than a month between January 2025 and early August 2026. Although the CDC has previously been led by acting directors at the start of an administration, the nearly yearlong gap since the departure of the administration’s first permanent director in August 2025 is without precedent. As of August 2026, the FDA is also currently without a Senate-confirmed commissioner following the previous commissioner’s resignation in May 2026. Additionally, public health agencies are experiencing increased politicization of their leadership ranks. In agencies such as the CDC and Food Safety and Inspection Service, the number of individuals in the Senior Executive Service—the most senior career leaders in government—has declined significantly, while at the same time the number of political appointees has reached record levels. (function(){function e(){window.addEventListener(`message`,function(e){if(e.data[`datawrapper-height`]!==void 0){var t=document.querySelectorAll(`iframe`);for(var n in e.data[`datawrapper-height`])for(var r=0,i;i=t[r];r++)if(i.contentWindow===e.source){var a=e.data[`datawrapper-height`][n]+`px`;i.style.height=a}}})}e()})(); (function(){function e(){window.addEventListener(`message`,function(e){if(e.data[`datawrapper-height`]!==void 0){var t=document.querySelectorAll(`iframe`);for(var n in e.data[`datawrapper-height`])for(var r=0,i;i=t[r];r++)if(i.contentWindow===e.source){var a=e.data[`datawrapper-height`][n]+`px`;i.style.height=a}}})}e()})(); At the CDC, for example, the number of career SES decreased 42.9% between December 2024 and February 2026, while the number of non-Senate confirmed political appointees at the agency was six times larger than the agency’s historical average from 2009 and 2024. Knowledgeable career leaders are integral to the ability of public health agencies to carry out their work with scientific integrity and professional judgment, and rapid leadership turnover and increased politicization threaten agencies’ ability to make evidence-based decisions to protect our health. The upheaval and politicization in public health agencies have also negatively affected employee engagement. Strong employee engagement is crucial to the ability of agencies to carry out their mission and successfully provide essential services to the public. In the 2025 Public Service Viewpoint Survey conducted by the Partnership for Public Service, the Department of Health and Human Services—which encompasses major public health agencies such as the CDC and FDA—had an employee engagement and satisfaction score of 20.4 out of 100, one of the lowest among large agencies. Only 2.8% of HHS employees indicated trust in their political leaders and only 8.7% reported confidence that they could report a suspected violation of law or regulation without retaliation. Employees at HHS also reported that the agency’s ability to provide services to the public had suffered. Nearly half of employees at HHS, 47.5%, said their work unit was worse at delivering quality services compared to its performance in 2024. In addition, 57.8% said their work unit was performing worse at fulfilling stakeholder needs. In addition to the work done within federal agencies, the federal government also distributes significant funding for public health and disease prevention work to state and local governments, nonprofits and small businesses—funding which has been significantly disrupted. At the CDC, for example, there was a 71.9% decrease in the amount of project grant funding issued in fiscal year 2025 compared to fiscal year 2024. The FDA also issued far less funding in fiscal year 2025—a 21.3% decrease from its fiscal year 2024 funding. Changes in federal funding include the ending of grants to community organizations that worked on HIV prevention and the cancellation of funding for research into improvements to patient safety and healthcare quality. These changes go beyond federal agencies to impact the broader public health ecosystem, including the state and local health departments responsible for much of the on-the-ground public health work in their communities. About 80% of the CDC’s domestic funding is directed towards state and local partners—meaning that cuts to CDC funding can ultimately result in cuts to state and local public health capacity. Federal agencies also provide expertise and assistance to state and local health agencies as they deal with particular health challenges, but workforce cuts have resulted in fewer federal employees available to help. The Impact of Changes to Public Health Capacity These changes to federal public health capacity are not abstract concerns. Disrupted programs, reduced funding and lost expertise at public health agencies across all levels of government threaten the public’s physical well-being and safety. In some cases, this has already led to harm. The most immediate impacts of federal cuts were seen in interruptions to ongoing public health programs and crisis responses. In one instance, when CDC grants were canceled during the 2025 Texas measles outbreak—the most severe measles outbreak in 25 years—public health officials in Lubbock, Texas were forced to pause parts of their measles response work supported by the frozen funding. Lubbock’s director of public health further said that a lack of available CDC experts to reach out to for advice “definitely” impacted the department’s response to the measles crisis. Cuts to federal funding also forced Dallas County Health and Human Services to cut staff and cancel 50 community vaccination clinics during the outbreak. Public health work outside of major outbreak responses was also disrupted. For example, in April 2025, the Milwaukee Public Health Department was unexpectedly unable to reach experts on lead poisoning due to firings at the CDC when responding to concerns about lead contamination in Milwaukee public schools. Due to federal workforce cuts, several programs at the CDC, including Alzheimer’s and epilepsy programs, have also become trapped in limbo—existing on paper, but without the staff necessary to operate. More recent crises reveal how federal cuts have weakened the public health infrastructure needed to prevent and respond to dangerous new outbreaks. Internationally, cuts at the U.S. Agency for International Development eliminated funding for disease testing and contact tracing abroad, which delayed detection of and responses to the 2026 Ebola outbreak in the Democratic Republic of Congo. While international outbreaks may seem far removed, the unchecked spread of disease in any country can quickly pose a danger to economic well-being, security and health around the world. Within the United States, public health cuts inhibited responses to the summer 2026 outbreak of the food-borne parasite cyclospora. At the federal level, cuts to funding for lab equipment and for CDC staff with expertise in parasitic infections—including 9 out of 11 staff members at the lab responsible for identifying parasitic outbreaks in 2025— contributed to the largest reporting delay in outbreak cases at the CDC in 15 years. Conflicting communications from the FDA about the source of the outbreak, which followed cuts to the agency’s communications department, additionally led to confusion among the public about how to best avoid infection. At the same time, cuts to HHS funding and support for local and state public health slowed some health departments’ responses to the crisis. The exact costs of these delays, constraints and confusion in public health responses are difficult to estimate. However, their message is clear: federal cuts have already made containing threats to public health even more of a challenge. Conclusion Protecting public health—from food safety to disease prevention—is one of the federal government’s most important missions. Dramatic and haphazard cuts to federal agencies and funding have already disrupted the public health system, impacting the response to challenges such as measles, lead poisoning and cyclosporiasis. The U.S. public health system needed improvement before these disruptions. Since 2022, federal leadership and coordination in response to public health outbreaks has been on the Government Accountability Office’s High-Risk List of areas in need of attention to improve government effectiveness and efficiency. Recent cuts only compound these concerns. The chaotic dismantling of government and resulting disruptions to crucial functions like public health and disease prevention highlight the need for meaningful reform and concrete policy proposals to reimagine how government can better serve the public and be more effective, responsive and accountable. To learn more about the impact of federal cuts to public health and science more broadly, visit The Cost of Cutting American Science. Learn more For more information on the Partnership for Public Service’s government reform initiative, visit Government for a New Era. View here In line with The Cost of Cutting American Science, federal workforce data in this brief is as of February 2026

ourpublicservice.org logo
Sep 9 • 9:00 AM EDT • Health • ourpublicservice.org
Leaked Video Shows iPhone 18 Pro's 3-in-1 Dynamic Island in Action

A leaker has activated Apple's upcoming three-item Dynamic Island mode inside the iOS 27 simulator, offering the first video demonstration of the new iPhone 18 Pro feature. The leaker, known as pdfu, posted a video showing the Dynamic Island toggling between three simultaneous Live Activities, matching what Bloomberg's Mark Gurman described in his report earlier today. "The new Dynamic Island with 3 items is already supported in iOS 27," pdfu wrote.

macrumors.com logo
Sep 9 • 8:57 AM EDT • Technology • macrumors.com
Is Senesi a long-term starter for Spurs?

"He's comfortable playing in a possession-based team, reads the game very well and has the personality to thrive in a demanding environment," Roberto de Zerbi said on Marco Senesi after Tottenham signed the defender in June. Senesi was a big get for Spurs. It was expected Senesi would slot straight into De Zerbi's starting XI - and he did for the Premier League opener away at Brentford.

sports.yahoo.com logo
Sep 9 • 8:48 AM EDT • Sports • sports.yahoo.com
Serbia dissolves parliament as snap elections called

Serbia will head to the polls in late October after President Aleksandar Vucic dissolved parliament following growing pressure from protesters demanding political change. However, Vucic plans to stand as a PM candidate.

dw.com logo
Sep 9 • 7:04 AM EDT • Politics • dw.com
Donald Trump Jr.'s venture capital firm rejects House Democrat's accusations of "insider political influence"

Rep. Jamie Raskin launched an investigation last month into the president's son's investment firm and its "almost clairvoyant" business moves.

cbsnews.com logo
Sep 9 • 6:05 AM EDT • Politics • cbsnews.com
High-Signal Publisher
GOP's first midterm convention kicks off Wednesday, putting Dallas at center of national politics

The Republican Party's first-ever midterm convention begins in Dallas as Trump and GOP leaders rally voters, while Democrats prepare their own counterprogramming ahead of November.

keranews.org logo
Sep 9 • 6:01 AM EDT • Politics • keranews.org
Democrats demand Trump administration halt collection of patients’ ER records

A group of Democratic lawmakers is calling for the Trump administration to suspend a new surveillance program it quietly launched to collect the personal and identifiable health data of Americans who visit emergency rooms.

cnn.com logo
Sep 9 • 6:00 AM EDT • Health • cnn.com
Fans face record prices for Ole Miss vs LSU game

Tickets for the Ole Miss vs LSU game are starting above 500 dollars as demand surges for the anticipated matchup.

sports.yahoo.com logo
Sep 9 • 5:31 AM EDT • Sports • sports.yahoo.com
SC clothing store agrees to pay Buc-ee’s $850,000 in trademark lawsuit

Born United, a clothing company based out of Summerville, agreed to settle its lawsuit with Buc-ee’s and pay the gas station giant $850,000 for using and selling apparel featuring its iconic beaver logo without permission.

postandcourier.com logo
Sep 9 • 5:00 AM EDT • Business • postandcourier.com
Schumer and Jeffries opposed a Brooklyn power play. It happened anyway.

The Brooklyn party chair rewrote the rules ahead of a leadership vote despite objections from the nation’s two most powerful Democrats, and some in the party are wondering if they could do more to stop her.

politico.com logo
Sep 9 • 4:45 AM EDT • Politics • politico.com
Parkinson demands more from Wrexham after draw

Manager Phil Parkinson acknowledges Wrexham have room for improvement after they were held to a 1-1 draw at home by Burnley.

sports.yahoo.com logo
Sep 9 • 4:21 AM EDT • Sports • sports.yahoo.com
Lane Kiffin and Livvy Dunne Just Made LSU Cool Again

I’m not saying Lane Kiffin is the most entertaining hire LSU has made in years. I’m just saying Livvy Dunne is suddenly back around LSU football. Coincidence? Absolutely. But let me have my fun. Dunne returned to Baton Rouge for LSU’s season opener against Clemson, watched the Tigers absolutely demolish the Tigers 51-10 and showed…

sports.yahoo.com logo
Sep 9 • 3:20 AM EDT • Sports • sports.yahoo.com
🙂 Positive (35%)
love
50%
wow
50%
Alleged victim of Alan Jones looked ‘sunken and diminished’, politician tells court

Downing Centre court hears that the alleged victim was usually outgoing but his demeanour changed at a meeting with Jones at his apartment

theguardian.com logo
Sep 9 • 2:00 AM EDT • Politics • theguardian.com
Unions inspired his political career, but can they help him beat Susan Collins?

The Maine Democratic Senate hopeful is running perhaps the most pro-labor campaign in the country — and labor is going all-in to elect him.

bostonglobe.com logo
Sep 9 • 12:01 AM EDT • Politics • bostonglobe.com
US Research Cuts Drive Scientists to Germany

US-based researchers are seeking academic asylum in Germany following the Trump administration’s funding cuts—a loss to American science.

the-scientist.com logo
Sep 9 • 12:00 AM EDT • Science • the-scientist.com
More Than 5,000 Leaders Across Entertainment, Academia and Public Life Unite to Reject “Genocide” Accusation Against Israel

Boris Johnson, Deborah Lipstadt, Sir Niall Ferguson, Shari Redstone, Steven Pinker, Sherry Lansing, Simon Sebag Montefiore, Chief Rabbi Warren Goldstein, Irwin Cotler, Debra Messing and thousands of others reject the genocide accusation against Israel and warn that it fuels antisemitism

creativecommunityforpeace.com logo
Sep 8 • 11:25 PM EDT • Entertainment • creativecommunityforpeace.com
Protesters seek universal health care in Springfield

Demonstrators gathered on Chestnut Street in Springfield to advocate for legislation establishing a single-payer health care system in Massachusetts.

wwlp.com logo
Sep 8 • 11:08 PM EDT • Health • wwlp.com
COVID-19 cases on the rise across all age groups, local healthcare expert says

Dr. Jason Bowling, the chief epidemiologist at University Health, said there is an increase in COVID-19 cases across all age groups.

ksat.com logo
Sep 8 • 9:46 PM EDT • Health • ksat.com
Canfield Fair incident puts focus on political rhetoric in Ohio governor’s race

For months, Ohio’s governor’s race has been fought with increasingly personal campaign messages.Now, after an armed man pushed through a crowd toward Democrati

abc6onyourside.com logo
Sep 8 • 9:40 PM EDT • Politics • abc6onyourside.com
Man accused of assault, inducing panic at Dr. Amy Acton event pleads not guilty

The armed Ohio man investigators said set off a security scare involving Democratic gubernatorial candidate Dr. Amy Acton pleaded not guilty in court Tuesday.

news5cleveland.com logo
Sep 8 • 9:13 PM EDT • Politics • news5cleveland.com
A (temporary) win for science and sanity

Congress rejects rule that would give Trump control over all research and academic grants—for now

48hills.org logo
Sep 8 • 9:12 PM EDT • Science • 48hills.org
Meet the Lehigh Valley's newest political bosses

Northampton County Democratic Chair Baron Vanderburg and Lehigh County Republican Committee Chair George Rivera want to change the course of politics in the Lehigh Valley.

lehighvalleypublicmedia.org logo
Sep 8 • 8:35 PM EDT • Politics • lehighvalleypublicmedia.org
Pappas, Sununu sweep to victory in U.S. Senate primaries

Pappas, a four-term Democratic congressman, will face off against Republican and former U.S. Senator John E. Sununu.

nhpr.org logo
Sep 8 • 8:23 PM EDT • Politics • nhpr.org
Pappas, Sununu sweep to victory in U.S. Senate primaries

Pappas, a moderate Democrat and current Congressman in the 1st Congressional District, will face off against Republican and former U.S. Senator John E. Sununu.

nhpr.org logo
Sep 8 • 8:23 PM EDT • Politics • nhpr.org
Deep dive
😐 Neutral (18%)
wow
72%
love
28%
Scientists in Chicago remotely controlled a wireless brain implant in South Korea over the internet

"The biggest challenge is demonstrating long-term safety and reliability in the human brain."

yahoo.com logo
Sep 8 • 8:13 PM EDT • Science • yahoo.com
John E. Sununu Wins Republican Senate Primary in New Hampshire

The general election race to replace Jeanne Shaheen, a Democrat, could help determine control of the U.S. Senate.

nytimes.com logo
Sep 8 • 8:08 PM EDT • Politics • nytimes.com
Chris Pappas Defeats Progressive Challenger in New Hampshire Senate Primary

Mr. Pappas, a moderate Democrat who has served four terms in the House, will face former Senator John E. Sununu, the Republican nominee, in November.

nytimes.com logo
Sep 8 • 8:05 PM EDT • Politics • nytimes.com
Rep. Chris Pappas will face former Sen. John E. Sununu in New Hampshire Senate race, CNN projects

Democratic Rep. Chris Pappas will face Republican former Sen. John E. Sununu in the race for New Hampshire’s open Senate seat, CNN’s Decision Desk projects.

cnn.com logo
Sep 8 • 8:00 PM EDT • Politics • cnn.com
Hundreds protest plans to close Philly's Academy of Natural Sciences: "We're going to make our voices heard"
cbsnews.com logo
Sep 8 • 7:34 PM EDT • Science • cbsnews.com
Deep dive High-Signal Publisher
😐 Neutral (19%)
love
60%
ahah
40%
The Nuggets have officially signed DeMar DeRozan …

The Nuggets have officially signed DeMar DeRozan …

sports.yahoo.com logo
Sep 8 • 7:21 PM EDT • Sports • sports.yahoo.com
Incumbent GOP governor rolls to primary victory after keeping Trump at a distance

Kelly Ayotte cruised past Republican primary challengers, setting up a high-stakes New Hampshire governor's race against Democrat Cinde Warmington.

foxnews.com logo
Sep 8 • 6:50 PM EDT • Politics • foxnews.com
Michigan rabbis lay out demands for El-Sayed and state Democrats to earn their votes

As the candidate seeks Jewish voters, an open letter describes Jewish sovereignty in Israel and Jewish safety as “nonnegotiables.”

jta.org logo
Sep 8 • 6:16 PM EDT • Politics • jta.org
2026's elections could test how skyrocketing trading on prediction markets affects races and results

Officials' fears revolve around the fear that pervasive financial incentives will further damage confidence in elections and democracy if Americans think they're influencing the outcome.

pbs.org logo
Sep 8 • 5:48 PM EDT • Politics • pbs.org
🙂 Positive (35%)
Supreme Court rejects Missouri Republicans’ request to use new congressional map

Republicans rushed to the high court after the Missouri Supreme Court ruled the state could not use the redrawn map, which was designed to eliminate one Democratic-held seat, this year.

nbcnews.com logo
Sep 8 • 5:35 PM EDT • Politics • nbcnews.com
High-Signal Publisher
Protesters rally against Academy of Natural Sciences closure

Protesters rallied outside the Academy of Natural Sciences Tuesday as the 198-year-old Philly museum prepares to close at the end of September.

metrophiladelphia.com logo
Sep 8 • 5:27 PM EDT • Science • metrophiladelphia.com
Democratic socialist candidates stirred the primary election pot. But can they win in November?

An MSU Denver political expert discusses what’s behind their emergence, what they stand for and whether they can achieve lasting impact.

red.msudenver.edu logo
Sep 8 • 5:05 PM EDT • Politics • red.msudenver.edu
Eye on Health: Couplet Care keeps families and babies closer during NICU stay

The NICU..or Neonatal Intensive Care Unit is designed for babies requiring special care immediately following birth. But not every NICU looks the same."The most

wsbt.com logo
Sep 8 • 5:04 PM EDT • Health • wsbt.com
Politics News Site NOTUS Rebrands as The Washington Sun

A trademark dispute scuttled its plans to relaunch as The Washington Star, so the site chose a different name.

nytimes.com logo
Sep 8 • 5:00 PM EDT • Politics • nytimes.com
Red Dead Redemption 2 free expansion is a new story set within an alternate timeline

If you need more post-game content, you've found it.

gamingbible.com logo
Sep 8 • 5:00 PM EDT • Technology • gamingbible.com
Control of State Senate up for grabs this November

Control of the Wisconsin Senate will hinge on key November races as Democrats seek two seats and Republicans push for a 2027 trifecta.

spectrumnews1.com logo
Sep 8 • 5:00 PM EDT • Politics • spectrumnews1.com
Crossland Construction Lab opens at Bentonville High School

Area schools are working with construction companies to introduce students to industry jobs through construction programs as demand for workers rises. A construction company executive hopes the programs will lead...

talkbusiness.net logo
Sep 8 • 4:15 PM EDT • Business • talkbusiness.net
We redshirted our son for kindergarten. Then he skipped a grade.

We held our son back for kindergarten because of different state cutoffs. When he became bored academically, we moved him ahead a grade.

businessinsider.com logo
Sep 8 • 3:50 PM EDT • Business • businessinsider.com
At rally to save Academy of Natural Sciences museum, protesters urge Drexel to 'act like it's an emergency'

Local lawmakers and scientists outlined several options to preserve the museum, which is due to close Sept. 30.

phillyvoice.com logo
Sep 8 • 3:15 PM EDT • Science • phillyvoice.com
Government land-grab agenda hits key Senate race as Dem backs property takeovers echoing Mamdani

Maine Senate candidate Troy Jackson suggested the state should take over mobile home parks, echoing NYC Mayor Zohran Mamdani's housing agenda.

foxnews.com logo
Sep 8 • 3:02 PM EDT • Politics • foxnews.com
B2B Marketing Leaders Struggle to Prove Business Impact: 10Fold

10Fold research finds B2B leaders measure more than ever but struggle to connect metrics to revenue. See the communications ROI reset.

demandgenreport.com logo
Sep 8 • 3:00 PM EDT • Business • demandgenreport.com
Berman campaign: “We’re going fishing” – ER nurse and Democrat Mitchell Berman launches first ad of general election in Wisconsin’s First District Congressional race

Spot features Berman fishing and focuses on ending corruption in Washington, contrasting Berman’s working class background and Republican Bryan Steil’s corporate special interests RAYMOND, Wis. — Today, Mitchell Berman, ER nurse and Democratic candidate for Wisconsin’s First Congressional District, launched...

wispolitics.com logo
Sep 8 • 2:57 PM EDT • Politics • wispolitics.com
Can the Mamdani model travel?

David Morales, a 27-year-old democratic socialist, is trying to knock off the mayor of Providence, Rhode Island.

politico.com logo
Sep 8 • 2:32 PM EDT • Politics • politico.com
NVIDIA's DLSS 5 Adds Subtle Details To NBA 2K27, But Demands A Lot More Power

DLSS 5's juice may not be worth the squeeze for launch title NBA 2K27.

engadget.com logo
Sep 8 • 2:31 PM EDT • Technology • engadget.com
Penn State Ranked No. 16 in Both Coaches, AP Polls

Penn State moved up in the week 1 version of the polls! They’re now No. 16 in the Coaches poll, as well as No. 16 in the AP. The absolute demolition of Marshall, maybe to a point not expected by the voters, allowed the Nittany Lions to start its ascent to a potential top 10 […]

sports.yahoo.com logo
Sep 8 • 2:06 PM EDT • Sports • sports.yahoo.com
Republicans were confident about keeping the Senate. Now the battle is wide open

Republicans appeared to have a firm grip on the majority at the start of the 2026 election cycle. But Democrats are now competing in states that once seemed well beyond their reach.

pbs.org logo
Sep 8 • 1:41 PM EDT • Politics • pbs.org
Stand Up for Science Demands Congress Stop Transfer of National Institutes of Health Research Funds to

New petition urges Congress to stop an interagency agreement that would allow health research money to fund War Department’s unspecified priorities.

einpresswire.com logo
Sep 8 • 1:23 PM EDT • Science • einpresswire.com
Stand Up for Science Demands Congress Stop Transfer of National Institutes of Health Research Funds to

New petition urges Congress to stop an interagency agreement that would allow health research money to fund War Department’s unspecified priorities.

einnews.com logo
Sep 8 • 1:23 PM EDT • Science • einnews.com
Pritzker, Eyeing 2028, to Help Midterm Democrats With a $20 Million Group

JB Pritzker, the billionaire governor of Illinois, is continuing to expand his national footprint, this time by using a new group to target Republicans in battleground races.

nytimes.com logo
Sep 8 • 1:20 PM EDT • Politics • nytimes.com
Hundreds rally to protest the planned closure of the Academy of Natural Sciences museum

The crowd was decidedly intergenerational.

inquirer.com logo
Sep 8 • 1:06 PM EDT • Science • inquirer.com
What Trump’s new study says about support for trans rights — and why experts are worried

This story was originally reported by Orion Rummler and Jasmine Mithani of The 19th. Meet Orion and Jasmine and read more of their reporting on gender, politics and policy. A new study from the Trump administration is sending alarm bells through pro-democracy groups for its potential to fuel a crackdown on Americans who support LGBTQ+ […]

michiganadvance.com logo
Sep 8 • 1:00 PM EDT • Politics • michiganadvance.com
USA TODAY Sports Super 15 East region football rankings, Week 4

St. Frances Academy stays solidly at the top, but a new No. 2 makes its rise.

sports.yahoo.com logo
Sep 8 • 12:45 PM EDT • Sports • sports.yahoo.com
😐 Neutral (29%)
Rally held to keep Philadelphia's Academy of Natural Sciences museum open

Protesters held a rally Tuesday calling for officials to save the Academy of of Natural Sciences museum in Center City Philadelphia.

6abc.com logo
Sep 8 • 12:34 PM EDT • Science • 6abc.com
😐 Neutral (14%)
wow
100%
STHS Hosting Webinar on Prostate Health & Early Detection, Sept. 15th

Between busy work schedules, family obligations and other daily demands, many men prioritize the needs of others before their own, often postponing annual checkups and routine preventive screenin

megadoctornews.com logo
Sep 8 • 12:24 PM EDT • Health • megadoctornews.com
Democrats Demand Trump Administration Halt Collection of Patients' ER Records

Senate and House Democrats say the Trump administration’s plan to collect patients’ medical data violates privacy and will discourage people from seeking medical care.

kffhealthnews.org logo
Sep 8 • 12:22 PM EDT • Health • kffhealthnews.org
Business internship presentations connect classroom learning to career readiness

Nineteen Penn State Lehigh Valley business students concluded their required summer internships by presenting what they learned to faculty and staff evaluators. The presentations culminated a semester-long process designed to help students connect their academic preparation, workplace experiences and career-readiness skills.

psu.edu logo
Sep 8 • 12:07 PM EDT • Business • psu.edu
The official sequel to The Ur-Quan Masters releases its free demo today

Blast your opponents in 1v1 arcade space battles like it's 1992 all over again.

arstechnica.com logo
Sep 8 • 12:05 PM EDT • Technology • arstechnica.com
Humann Names Dr. Harold Schmitz Science Advisory Chair and Announces Nutrition Research Partnership with the UC Davis Innovation Institute for Food & Health

/PRNewswire/ -- Humann, the Austin-based cardiovascular health supplement company, continued its legacy of engaging with leading academic institutions by...

prnewswire.com logo
Sep 8 • 11:57 AM EDT • Science • prnewswire.com
Live Results: Rhode Island midterm primaries

Rhode Island Gov. Dan McKee faces a tough Democratic primary challenge Wednesday in his bid for a second full term.

pbs.org logo
Sep 8 • 11:55 AM EDT • Politics • pbs.org
Live Results: New Hampshire midterm primaries

The race to replace retiring three-term Democratic Sen. Jeanne Shaheen is one of a handful across the country that could determine control of the U.S. Senate for the second half of President Donald Trump’s final term.

pbs.org logo
Sep 8 • 11:50 AM EDT • Politics • pbs.org
Proposed Changes to Head Start Undermine Its Role in Promoting Child Nutrition and Healthy Eating - Food Research & Action Center

Published September 8, 2026 For more than 60 years, Head Start has supported young children during their most important phase of growth and development. For families with limited resources, Head Start is a trusted source of care, education, nutritious meals, and health services. Despite Head Start’s long history of bipartisan support, and demonstrated success, the U.S. Department of Health and Human Services (HHS) has a proposed new […]

frac.org logo
Sep 8 • 11:43 AM EDT • Health • frac.org
Deep dive
😐 Neutral (17%)
ahah
51%
love
49%
Ballon d’Or nominee list revealed

The nominees for this year’s Ballon d’Or have been revealed. The winner of the award, organised by France Football, will be announced in Paris on 26th October. Ousmane Dembélé won the award last...

sports.yahoo.com logo
Sep 8 • 11:10 AM EDT • Sports • sports.yahoo.com
‘Democrats Are Behind’: PAC Wants Party to Catch Up on A.I.

The group is starting with more than $10 million and says it intends to support midterm House candidates in swing states.

nytimes.com logo
Sep 8 • 11:00 AM EDT • Politics • nytimes.com
BIM 2.0: unfinished business

BIM 2.0: unfinished business. Revit wasn't finished at launch — so why demand perfection from its challengers now?

aecmag.com logo
Sep 8 • 10:59 AM EDT • Business • aecmag.com
UnitedHealth’s Democrat investment, and surprise billing bloat debate

UnitedHealth execs shower a top Democrats with cash, and the No Surprises Act debate heats up.

statnews.com logo
Sep 8 • 10:51 AM EDT • Health • statnews.com
AZ's R&D chief Barr touts internal 'science success story' after IL-33 antibody's stellar showing in COPD

With a detailed data drop that AstraZeneca’s R&D chief described as an internal “science success story,” the British Big Pharma has secured an FDA priority review for what it believes could become a flagship biologic in chronic obstructive pulmonary disease (COPD). In detailed results from the late-stage Oberon and Titania trials—first teased in March and detailed in full at the European Respiratory Society Congress in Barcelona this week—the drugmaker laid out the extent of its IL-33 inhibitor’s potential to reduce moderate and severe exacerbations in a wide range of COPD patients still struggling with those “lung attacks,” as AstraZeneca’s Sharon Barr, Ph.D., called them, despite using standard-care inhaled therapy. In the headline results, a 300 mg dose of tozorakimab given once every four weeks curbed those moderate and severe exacerbations in the studies’ primary population of former smokers by 29% in the Oberon study and 34% in Titania. In the overall population of both current and former smokers, these reductions were 30% and 29%, respectively, versus placebo and inhaled standard of care. The benefits also extended to clinically meaningful exacerbation reductions in all prespecified patient subgroups and specifically turned up promising signals in patients across a range of blood eosinophil counts, with Barr telling Fierce that “it’s the details that make this even more exciting than the high-level results that we’ve already shared.” In fact, during AZ’s tozorakimab poster presentation at the ERS 2026 Congress this past weekend, attendees were so enamored by the data that event organizers had to encourage people to clear the room and look at the other presentations on offer, Barr said in an interview. “I think it really speaks to the fact that there is a lot of buzz around these data because the entire respiratory community has been so desperate for new therapies for these patients,” she explained. The respiratory disease continues to represent a “staggering unmet medical need,” Barr said, highlighting the COPD exacerbations that the Oberon and Titania studies homed in on, which she added carry a greater mortality risk than a heart attack. “When a patient has a severe exacerbation, only about half of them are still alive within three and a half years,” she pointed out. As for tozorakimab specifically, Barr christened the molecule “an AstraZeneca science success story,” harkening several years back to the point at which researchers began to explore IL-33 as a driver of respiratory disease, and COPD in particular. At the same time, “there was still so much that wasn’t understood,” she admitted, highlighting the insight that IL-33 signals through both ST2 and EGFR through the RAGE pathway, a discovery Barr attributed to AstraZeneca's own scientists. Understanding the need to tackle both pathways in COPD—and aware of competitor candidates in the hopper, including one that bound ST2—the company ultimately had to make some “courageous decisions,” Barr said. These included taking a prior COPD molecule offline and going back to the drawing board to reinvent its potential IL-33 label “to make sure that we had a molecule that could block signaling through both arms of the pathway, through both the reduced form and the oxidized form, knowing that we wouldn’t be first, but striving to be best.” “When we put [tozorakimab] into the clinic, we firmly believed that we had a differentiated molecule, and we saw the other molecules blocking just ST2 or partially blocking IL-33, unable to deliver two positive pivotal studies in COPD,” Barr explained. “We kept marching forward because we believed our molecule was differentiated, and now I think we have the clinical validation that supports that.” Ultimately, AstraZeneca finds itself on much better footing these days when it comes to potential biologic rivals to tozorakimab in COPD. Sanofi and Regeneron’s Dupixent, for instance, is approved to treat COPD exacerbations in patients with high eosinophil counts, but not low ones. Meanwhile, the future has become cloudier for other next-gen IL-33 candidates from Sanofi and Regeneron, as well as Roche, which have suffered trial flops in recent years. One other potential ingredient for AstraZeneca’s success in its duo of studies was that the company was “ambitious in the trial design, willing to look at an all-comers population,” Barr said, “and willing to enroll the most severe patients.” Prior studies for would-be biologics rivals in COPD “avoided enrolling” those patients, she pointed out. She also highlighted the Big Pharma’s painstaking design of exacerbations in its trial, which “gave us a very rigorous readout,” and pointed to “the extra effort and investment” the company put in to understand the effect of mucus plugs in patients. Barr described mucus production as a “key feature in disease diversity,” noting that mucus plugs—obstructing clumps of mucus that block patients’ airways—are associated with worse outcomes in COPD. In its data announcement, AstraZeneca noted that an integrated analysis of Oberon and Titania found tozorakimab “demonstrated a reduction in patients’ mucus plug score,” with the pharma claiming its biologic is the first to deliver such results in a broad COPD population. “So being able to reduce those mucus plugs, we expect, is an important part of driving benefit for patients who are living with COPD,” Barr said. Again touching on the breadth of the study populations, Barr added that tozorakimab “worked across all eosinophil levels in both current and former smokers across all levels of lung function,” which she suggested “really simplifies decision-making for clinicians, and it allows them to offer therapy to the broadest possible patient population.” In the highest patient eosinophil count group, tozorakimab helped chart a 43% reduction in exacerbation risk, which Barr stressed were “unprecedented data.” In the mid-level group, AZ’s drug delivered a 23% reduction and, in the lowest group, a 34% reduction in eosinophils, which Barr said suggests efficacy “in all patient subgroups.” As for AZ’s recent guidance upgrade on the medicine’s sales opportunity, the lift from a $3 billion to $5 billion range to $5 billion plus was informed by multiple factors, Barr said, including the fact that “in 2024, there were multiple competitors, and there aren’t anymore.” Additionally, “we know that this is a massive unmet medical need, and this is a really incredible set of data that we think will be very convincing to the clinical community,” Barr said. Looking ahead to a potential evolution of the COPD treatment landscape, Barr noted that most patients start treatment in the community with an option like a triple therapy, and for them, having an option like AstraZeneca’s inhaler Breztri will remain a “really important part” of that journey. But of the patients uncontrolled on triple therapy, which Barr described as “about half of them today,” just a “small fraction” are currently eligible for biologic therapy, which she emphasized AstraZeneca is working to change. Understanding that COPD is not a “one-size-fits-all” disease, AstraZeneca is also looking at its antibody drug Tezspire for patients with T2-driven disease, and the company continues to think about new mechanisms for tackling COPD through both systemic and inhaled drugs, Barr said.

fiercebiotech.com logo
Sep 8 • 10:50 AM EDT • Science • fiercebiotech.com
UC Berkeley Law event targets Trump science policies as ‘censorship’

​The University of California, Berkeley School of Law organized an Aug. 25 discussion focused on resisting censorship and protecting academic freedom in scientific research.

campusreform.org logo
Sep 8 • 10:43 AM EDT • Science • campusreform.org
Health care features prominently in Democrats’ agenda

Democrats are sharpening their health care plans as the midterm elections near.

statnews.com logo
Sep 8 • 10:22 AM EDT • Health • statnews.com
Alonso on injuries, Estevao reports and being 'self-demanding'

Chelsea boss Xabi Alonso has been speaking to the media before Wednesday's Carabao Cup third-round tie against Leeds United at Stamford Bridge (kick-off 20:00 BST). Caicedo could be back for Saturday's Premier League game against Hull City, though. Levi Colwill will be available for selection, but Jordan Henderson and Emmanuel Emegha will not feature.

sports.yahoo.com logo
Sep 8 • 10:08 AM EDT • Sports • sports.yahoo.com
Penélope Cruz and Javier Bardem Say 'It's Impossible' Not to Talk Politics After Starring in Projects Like 'Bunker'

Penélope Cruz and Javier Bardem agree that "it's impossible" not to talk politics as actors when they're starring in timely stories

thewrap.com logo
Sep 8 • 10:00 AM EDT • Politics • thewrap.com
Byron Donalds predicts conservative Democrats will back him over David Jolly

'They're saying, "I don't want to be a part of this."'

floridapolitics.com logo
Sep 8 • 9:32 AM EDT • Politics • floridapolitics.com
Javier Bardem, Penelope Cruz Tackle Politics at 'Bunker' Presser

Bardem's wife, Penelope Cruz, admitted she worries about the role of women today as the couple joined director Florian Zeller and co-stars Stephen Graham, Paul Dano and Paul Schwarzenegger ahead of the Venice premiere of 'Bunker.'

hollywoodreporter.com logo
Sep 8 • 9:20 AM EDT • Politics • hollywoodreporter.com
Wilbur O. and Ann Powers College of Business remains No. 1 in South Carolina, climbs nationally in Niche rankings

The Wilbur O. and Ann Powers College of Business begins the academic year with continued recognition at both the state and national levels.

news.clemson.edu logo
Sep 8 • 9:19 AM EDT • Business • news.clemson.edu