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2027 Bon Jovi tour: How to get tickets to 'The Forever Tour,' general sale times, new dates and more
Bon Jovi is back! Here's how to get tickets to the rock band's 2027 tour.
Chrishell Stause announces split from partner G Flip
Chrishell Stause and G Flip attend the Los Angeles premiere of 'Girls Like Girls' at Universal Studios AMC at CityWalk Hollywood on June 15, 2026, in Universal City, California. (Amy
Transmission Lines Could Have Cut Through the Ranch of a Billionaire Abbott Donor. Then Planners Made Them Go Away.
As hundreds of landowners fought to keep towers off their land, Kelcy Warren saw wholesale relief—without filing an official protest.
Reckitt cuts sales outlook as Lysol and China businesses hit
Group’s European business returned to growth despite ‘challenging’ consumer environment and lower cold and flu incidence
The case for 'Climate Popularism’: A new politics for an age of ecological crisis
Climate resilience and adaptation remain largely neglected in UK politics, a glaring omission our proposal aims to address.
Election Day: A complete guide to Israel’s political parties and what they stand for
The Jerusalem Post has prepared a series of explainers breaking down the platforms, leaders, and main positions of the main parties running in the election.
Principal’s small business benefits arm posts 10% sales growth in a softening market
Specialty benefits loss ratio holds below target range as Beam Benefits adds its first customers
Japanese firms eye up to 50% stake in JYP Entertainment as agency denies proposal
Two Japanese investment firms say they may seek up to 50 percent of JYP Entertainment, though the agency says it received no proposal.
Business Scholar Luncheon Series Presents ‘Ways to Finance Your Business’ Nov. 4 At SALA
Visit the post for more.
Dallas' Colossal raises $200 million to genetically engineer military dogs
The hunter gatherers who first selectively bred wolves for specific tasks 11,000 years ago could never have seen this coming. Last Thursday, a joint venture between Dallas’ Colossal Biosciences and
Xbox sale round-up October 27, 2026
New Xbox sales are now live, with big discounts on BioShock, No Man's Sky, BioShock Infinite, Atomic Heart, Astroneer, BioShock 2, We Happy Few and more
FLAT-WHITE: from target trial emulation to federated high-throughput causal machine learning using decentralized real-world data
npj Health Systems - FLAT-WHITE: from target trial emulation to federated high-throughput causal machine learning using decentralized real-world data
Japanese Group Targets 50% Stake in JYP Entertainment
Japanese Group Targets 50% Stake in JYP Entertainment NEXROC and SVCV plan 30% premium tender; JYP denies receiving acquisition proposal
Here's How The Way Activision Talks About Call Of Duty Launch Weekend Sales Has Changed Over Nearly 20 Years
It hasn't been bragging about Modern Warfare 4 sales despite rave reviews
Samsung’s Switch 2-ready MicroSD Express card is on sale for less than $50
You can save on extra storage for your Switch 2.
FCRA finances show declining property sales, major capital spending
The Fort Chaffee Redevelopment Authority (FCRA) reported declining property-sale revenue between 2021 and 2025, while expenditures fluctuated significantly as the authority continued redevelopment and infrastructure projects at Chaffee Crossing. A...
Cook County Public Health Reminds Families to Get Their Children Tested for Lead - Cook County Department of Public Health
In recognition of National Lead Poisoning Prevention Week, Oct. 25-31, Cook County Department of Public Health is bringing increased attention to Illinois’ new universal childhood blood lead testing law and lead dangers. The new state lead testing requirements, which took effect July 1, 2026, require all children to receive blood lead tests at ages 12 months and 24 months, regardless of where they live. Also, children 6 years old and younger must receive a lead exposure risk assessment through a questionnaire administered by a healthcare provider.
LAPD seizes $1M in stolen shoes, backpacks from Chatsworth business
The recovered merchandise included shoes from Brooks, Hoka, New Balance, Adidas, On and Salomon, as well as JanSport backpacks.
8 Companies to Watch for a Potential Sale in 2027
Dealmaking across the behavioral health industry continues to face challenges. However, no single thing explains the relative disquiet in behavioral
FF EAI Robotics Ecosystem (FFR) Completes Acquisition of FFAI Robotics Business, Establishing a Nasdaq-Listed Humanoid and Bionic Robotics Platform October Robot Sales Expected to Exceed 300 Units; Unveils FF OmniMind, a Unified AI Brain for All Robots
FF EAI Robotics Ecosystem Inc. (NASDAQ: FFR) ("FFR" or the "Company") a U.S.-based Embodied AI robotics company, today announced at the deal closing and its first Investor Day event in New York that it has completed its acquisition of the robotics business and related assets of Faraday Future Intelligent Electric Inc. (NASDAQ: FFAI) ("FFAI" or "Faraday Future") on October 23, 2026. The related business operations and assets have been transferred to FFR, and FFR has issued and delivered common sh
From iPhone Duo to Mac, Craft shows what a native productivity app can do
It’s been a busy fall for Apple. iOS and macOS 27 arrived in September, iPhone Duo went on sale just...
Adam Brody regrets his ‘very pedestrian’ proposal to Leighton Meester: ‘She deserved more’
“The only thing romantic about it was the speed,” the “Nobody Wants This” star admitted.
Business Ins & Outs: 260 Sample Sale, Spicewalla, Olli; Bonne Vache
The hits just keep on coming …
Free health and wellness event held for farmworkers in Salinas
A free event in Salinas provided farmworkers and their families with health care services, legal resources, and scholarships recognizing their achievements.
Wilmington Health facility sells for $9.4M
Wilmington Health’s main facility recently sold for more than $9 million. The 66,000-square-foot facility located at 1202 Medical Center Drive was purchased by Charlotte-based real estate investment firm Cedar Square in a $9.4 million sale-leaseback transaction, according to a deed recorded Oct. 21. Wilmington Health will continue leasing the facility, CEO Jeff James told the Business Journal in September. James said the lease term would likely be five years, with most services eventually transferring to a new medical office building under construction in the Midtown Park office area near The Pointe at Barclay. The Wilmington Health facility was originally listed earlier this year at $11.85 million. A Wilmington Health representative did not respond to a request for comment by press time. Steve Hall, vice president of BlueCoast Commercial, represented Wilmington Health in the transaction. “Wilmington Health wanted to unlock the value in its real estate without disrupting a single patient visit, and a sale-leaseback let them do exactly that,” said Hall in a text to the Business Journal Monday. “Cedar Square gets a long-term, absolute net investment anchored by one of the region’s leading physician groups, and Wilmington Health keeps its home on Medical Center Drive while redeploying that capital into care.” The sale marks Cedar Square’s first entry into the Wilmington market, according to Jon Dixon, the firm's managing partner and founder. “We are attracted to Wilmington's growth and what we see as strong long-term fundamentals,” said Dixon in an email Monday. “Population growth, relative affordability, and quality of life make it a compelling market for us. The climate and proximity to the coast are a big part of that appeal.” He added, “We hope to pursue additional opportunities across retail, industrial, medical office and multifamily in Wilmington. We will evaluate opportunities individually and remain disciplined about the properties we pursue. We would like this acquisition to be the beginning of a broader investment presence in Wilmington.” Given the facility’s age, Dixon said the site could eventually be redeveloped, potentially for medical office space or housing. Dixon said recent announcements from UNC Health and Atrium were among the factors behind the firm’s growing interest in Wilmington’s medical-office market. The announcements involve competing proposals for hospital expansion in New Hanover County, which are subject to the state’s Certificate of Need process. “Medical office remains one of the most sought-after asset classes in commercial real estate,” said Hall, “and well-located (medical office buildings) with strong operators are scarce in Southeastern North Carolina.” According to Dixon, Cedar Square describes itself as a boutique, hands-on real estate investment firm that values direct relationships with tenants and the communities where it owns property. “We’re very hands-on, and we like to be in direct contact with all of our tenants and the communities in which we own,” Dixon said. He added, “We’re definitely interested in building a presence with local owners, brokers and businesses or tenants.”
Penn State, Matt Campbell Hit With Bad Recruiting News
A winless Big Ten start worsens as three-star linebacker Blake Betton flips his commitment to Wisconsin, leaving Matt Campbell scrambling to salvage the Nittany Lions' 2027 class.
Will Proposal 2 get money out of politics? One researcher says ‘not really’
Michigan’s Proposal 2, which seeks to limit political spending by regulated utilities and government contractors, faces potential legal challenges due to existing Supreme Court rulings protec…
Zelda 40th Anniversary Switch 2 Pro Controller restock tracker: we’re watching these retailers
🎮 Nintendo will release a Zelda 40th anniversary Switch 2 Pro Controller on October 29 💰 It costs $99.99, the same as other limited editions 📅 A restock could occur on launch day at Walmart and Best Buy 🚨 Our Zelda Switch 2 Pro Controller restock tracker @mattswider on X will send out an alert when stock appears Walmart: Zelda Pro Controller Best Buy: Zelda Pro Controller Amazon: Zelda Pro Controller Target: Zelda Pro Controller GameStop: Zelda Pro Controller Nintendo is releasing a special limited edition Nintendo Switch 2 Pro Controller to celebrate the 40th anniversary of The Legend of Zelda series. It releases on October 29, 2026, which is when we expect to see a long-awaited restock of the hard-to-find controller. 🚨 We’re tracking Zelda Switch 2 Pro Controller stock updates. If you’d like to know when more stock arrives, follow Matt Swider on X and turn on notifications. You can also become a free or paid subscriber to The Shortcut to help support our work. 🚨 The Switch 2 Pro Controller features the same striking gold and royal emerald color scheme of the Nintendo Switch 2 The Legend of Zelda 40th anniversary edition, and also includes a fun little easter egg on the back: an 8-Bit Link. 🚨 Want the Zelda 40th Anniversary Switch 2 Pro Controller? Drop your email for restock alerts before it sells out. ⤵️ Subscribe This is the same Nintendo Switch 2 Pro Controller we’re used to, aside from the intricate design, but it means you’ll have to pay more as a result. It costs $99.99 instead of the standard $89.99. However, the Pro Controller is the easiest way to play the best Switch 2 games in TV mode. If you’ve been searching for a Zelda 40th Anniversary Switch 2 Pro Controller restock, here’s everything you need to know. Zelda 40th anniversary Switch 2 Pro Controller should restock at these retailers We’ve seen retailers such as Walmart and Best Buy restock items on release day, even when pre-orders have sold out. It’s likely that the Zelda Switch 2 Pro Controller will be up for grabs on October 29, 2026, when the controller and console launches. Demand will be high, and stock could sell out fast. However, we’ll be keeping a close eye on every major retailer, including Target, Amazon, GameStop, and the Nintendo Store and will alert our followers as soon as stock goes live. Why you can trust our Zelda Switch 2 Pro Controller restock tracker We’ve already helped over 400,000 people buy a PS5 when it was in and out of stock during Covid, and we’ve helped our subscribers continue to secure hard-to-find items. The Shortcut followers were some of the first to secure the Switch 2 when it went on sale, and we’ve also helped countless others snag limited edition consoles like the PS5 30th anniversary edition. The Shortcut and Matt Swider on X offer exclusive Zelda 40th anniversary Switch 2 Pro Controller restock updates with up-to-the-second US store inventory checks at the biggest retailers. You’ll receive an instant notification on X (if set to on) as soon as new stock arrives. Up next: Call of Duty: Modern Warfare 4 review roundup: ‘a strong return to form’ Subscribe Adam Vjestica is The Shortcut’s Senior Editor. Formerly TechRadar’s Gaming Hardware Editor, Adam has also worked at Nintendo of Europe as a Content Marketing Editor, where he helped launch the Nintendo Switch. He also runs a retro gaming YouTube channel called Game on, boy! Follow him on X @ItsMrProducts.
Follow the science
By Robert Royal Surveys of young people show that many lose their faith because they believe science has refuted religion. Among many other factors, this error is a major challenge for the Church, one that does not receive nearly the…
After the Earthquakes, Venezuela Faces a Longer Health Emergency
Four months after two powerful earthquakes devastated northern Venezuela, aid workers say the country is confronting a deepening health crisis. Chronic illness, disrupted medical care, and psycholo…
Mid-Columbia Ballet prepares for 50th anniversary of "The Nutcracker"
RICHLAND, WA. — For 50 years, the Mid-Columbia Ballet has brought the holiday classic The Nutcracker to audiences in the Tri-Cities. This year, the organization is celebrating that milestone with 144 dancers, new costumes and months of preparation to bring the beloved production to life. The annual performance is a major undertaking for the dancers, instructors and volunteers who work behind the scenes to make the show possible. Rehearsals span 13 weeks, with dancers practicing four days a week for multiple hours at a time.This year’s production will feature new costumes for the Waltz of the Flowers, including a sequence with as many as 25 dancers on stage at once. The show also brings together performers across generations, including adults who have been part of the production for more than 20 years. For Artistic Director Debra Rogo, the preparation begins long before the curtains open.Rogo has been involved with the Mid-Columbia Ballet for 40 years and says planning for The Nutcracker takes place throughout the year. While organizing a production of this size requires significant time and effort, she says watching young dancers grow and develop a passion for ballet makes it all worthwhile. “It’s why I do this,” Rogo said. “It is overwhelming ina good way. To be able to share into their lives and watch them develop a love of this art form and the hard work … it makes me very proud.”Rogo’s decades of involvement reflect the lasting impact the production has had on the local dance community. For many performers, The Nutcracker is more than a seasonal performance. It is an opportunity to build skills, create relationships and become part of a tradition that continues year after year.While the dancers spend weeks rehearsing their routines, a large team of volunteers works behind the scenes to support the production.More than 100 volunteers are involved this year, helping make the performance possible. Their contributions reflect the range of people who come together to support the arts in the Tri-Cities.Randy Haven, a longtime volunteer, says the sense of community is one of the things that makes the experience so special.“The people that you hear volunteering, it’s incredible,” Haven said. He described seeing people from different backgrounds working together backstage, from employees at Hanford to parents raising large families.Haven says that shared commitment creates a family-like atmosphere among the people involved in the production. For Rebecca and Torrie, the Mid-Columbia Ballet has been part of their lives since childhood. Both began dancing with the organization at age seven and have since returned as teachers, helping introduce the next generation to the art form.Their connection to the ballet has continued into their adult lives, creating an opportunity to share their love of dance with younger performers.Torrie now has three daughters performing in The Nutcracker, giving her the chance to watch them experience a tradition that was also part of her own childhood.Being able to see her daughters participate in the production has made the experience especially meaningful, she said.Although audiences can see productions of The Nutcracker in major cities such as New York and Seattle, those involved with the Mid-Columbia Ballet say the local performance offers something distinctive.The community atmosphere allows audiences to experience the production while supporting local performers and the people who dedicate their time to the arts.Rebecca says experiencing a live performance alongside other people is particularly meaningful in a world where so much time is spent looking at screens.She believes live art gives people an opportunity to connect with one another through a shared experience.The ballet’s production also gives local dancers the chance to perform for their community while continuing a tradition that has been part of the Tri-Cities for five decades. When to see ‘The Nutcracker’ in RichlandThe Mid-Columbia Ballet will present its 50th-anniversary production of The Nutcracker Dec. 10 through Dec. 13 in Richland.Tickets go on sale Nov. 1. Audiences can look forward to seeing 144 dancers, new costumes and the work of more than 100 volunteers come together for the holiday production.COPYRIGHT 2026 BY APPLE VALLEY NEWS NOW. ALL RIGHTS RESERVED. THIS MATERIAL MAY NOT BE PUBLISHED, BROADCAST, REWRITTEN OR REDISTRIBUTED.
Greenville Country Music Fest reveals 2027 lineup. See the headliners
Greenville Country Music Fest has unveiled its 2027 lineup, featuring Gavin Adcock, Sam Barber and Ty Myers ahead of ticket sales.
Greenville Country Music Fest reveals 2027 lineup. See the headliners
Greenville Country Music Fest has unveiled its 2027 lineup, featuring Gavin Adcock, Sam Barber and Ty Myers ahead of ticket sales.
Here are 16 businesses listed for sale in Arlington as of October 2026
A longtime Italian restaurant, a rolled ice cream shop and a family-owned auto repair shop are among more than a dozen local businesses that have been recently listed for sale in Arlington. The businesses appeared for sale as blind items on the online marketplace BizBuySell. Here's a look at some notable listings that are active
Salesforce vs. International Business Machines: Which Technology Stock Is a Better Buy in 2026?
Salesforce trades at a lower forward multiple, while IBM offers cheaper valuation on sales, but their balance sheets tell starkly different stories.
Faris Moumbagna relegated to Marseille reserves
Whilst Olympique de Marseille have a paper-thin squad following the summer fire sale, Bruno Genesio has made some strong calls with his squad management in recent weeks. As reported by La Provence, Ke...
INEOS puts Lausanne-Sport up for sale: Are Jim Ratcliffe’s sports investments working?
The Manchester United minority owner's company bought the Swiss club in 2017 — but the INEOS empire is now in retreat.
THE WEEK OF OCT 26, 2026
- FCC to discuss spectrum proposals - NOAA satellites under House Science scrutiny - NASA Science changes mission selection
What audience data says about the 2026 Latin Grammy nominees
Viberate reports on audience data for the 2026 Latin Grammy nominees, highlighting Rosalía's "La Perla" for Record of the Year and Aria Vega for Best New Artist.
What audience data says about the 2026 Latin Grammy nominees
Viberate reports on audience data for the 2026 Latin Grammy nominees, highlighting Rosalía's "La Perla" for Record of the Year and Aria Vega for Best New Artist.
A Dead Salmon's Fake Brain Activity Still Haunts Science, and AI Tools Can Fall for the Same Trap
A dead salmon once showed fake brain activity on an fMRI scan. Now AI researchers say tools that explain AI models face the same statistical trap.
Slotland Entertainment unveils Día de los Muertos Ricos! Mega Matrix slot
Festive skeletons, colossal symbols and mystery prizes bring the Mexican Day of the Dead to life this Halloween season.
Richard Hughes' mistake now looks painfully obvious
Last summer saw plenty of turnover at Anfield, with several stars leaving for free at the end of their contracts. Ibrahima Konate, Mohamed Salah and , three of the Reds' most iconic players across the...
Scientists solve mystery of 1,000-mile cloud floating on Mars
Space enthusiasts and astronomers have been tracking one of the Red Planet’s most fascinating atmospheric mysteries for years: a colossal plume officially known as the Arsia Mons Elongated Cloud (AMEC). AMEC was first discovered in 2018 and quickly became one of the most elusive answers for scientists. Researchers have now resolved this mystery using the […] Read the original article here: Scientists solve mystery of 1,000-mile cloud floating on Mars
Meta looks to raise up to $95 billion from stock sales for AI build out
Meta is seeking more cash as it spends heavily on AI infrastructure, data centers, and computing power as it develops consumer AI products.
Liza Minnelli bombed in many movies. So why do people still love her?
ASK MICK LASALLE: The Chronicle movie critic emeritus answers questions about Liza Minnelli, Dolly Parton and his favorite documentaries, with 11 films he says are worth seeking.
Universal Health Services earnings: what to look for from UHS
Hospital management company Universal Health Services (NYSE:UHS) will be announcing earnings results this Tuesday after market close. Here’s what to expect.
Top salaries at Endeavor Health Clinical Operations
The nine-hospital system announced plans this month to merge with Rush University System for Health.
Top salaries at Endeavor Health Clinical Operations
The nine-hospital system announced plans this month to merge with Rush University System for Health.
Nvidia's AI growth drives leadership shifts in sales and marketing
Nvidia's sales and marketing leadership is changing as veterans retire, outsiders bring new expertise, and Jensen Huang's daughter gains influence.
Business News: Audemars Piguet Unveils 'The Watch Keepers' - A Digital Platform Offering Certified Pre-Owned Watches
The Le Brassus watchmaker will facilitate sales and auctions of brand-certified timepieces on a digital platform launching in Switzerland and Europe, with plans for expansion to other markets, including the U.S.
Texas adopts new water disclosure for land sales
Texas now requires many land sellers to disclose groundwater and surface water rights before closing a land sale under Texas Real Estate Commission rules.
Goldwind Science & Technology: 9M26 profit reached RMB2.9 billion as WTG sales rose and backlog hit 57.0 GW
9M26 revenue was RMB52.0 billion and attributable net profit RMB2.9 billion. WTG sales rose 3.02% YoY, while total backlog reached 57.0 GW; operating cash flow was negative RMB30 million.Original document: Goldwind Science & Technology Co. Ltd. Class A [002202] Slides Release — Oct. 26 2026This is…
How to Manage Symptoms of Heart Failure
(Feature Impact) Americans are facing a growing health challenge, with 1 in 4 adults at risk of heart failure, according to the Heart Failure Society of America. Additionally, approximately 6.7 million U.S. adults who are 20 years old or older are currently living with heart failure, and that number is projected to reach 8.7 million by 2030. googletag.cmd.push(function() { googletag.display('JGFI_Article_300x250'); }); Managing heart failure is a significant expense to the U.S. healthcare system, costing the nation approximately $40 billion in 2020 and expected to increase to approximately $142 billion a year by 2050.If you (or a loved one) are living with the condition, consider these tips to help manage it.Adhere to the Treatment and Follow-Up PlanOngoing outpatient care is important when managing heart failure. Understand the treatment plan provided by your healthcare team, make diet and lifestyle changes, take medications as directed and keep recommended follow-up appointments.Pay attention to changes in symptoms and communicate with your healthcare provider if treatment does not seem to be working as expected. If their conditions are left unmanaged, patients can experience a range of heart-failure-related symptoms such as shortness of breath, fatigue, buildup of fluid and more.Understand Challenges with Diuretic TreatmentDiuretics help the body remove excess fluid and are commonly used to treat swelling, or edema, associated with heart failure. Your provider may try different diuretics, sometimes referred to as “water pills,” to manage your heart failure symptoms. However, intravenous (IV) diuretic therapy may be required for some patients if symptoms continue.Ask About Treatment Options Before IV Care Is NeededFor some adults, a healthcare provider may consider recommending an at-home, non-oral diuretic option prior to escalating to IV therapy.For example, ENBUMYST™ (bumetanide nasal spray) is a prescription diuretic used in adults to treat edema associated with congestive heart failure. It’s administered as a nasal spray for short-term use to manage excess fluid with the goal of transitioning to oral diuretic therapy when appropriate.Talk with your healthcare provider to learn more and visit enbumyst.com. Read the full Prescribing Information and Patient Information.Photo courtesy of Shutterstock googletag.cmd.push(function() { googletag.display('JGFI_Article2_300x250'); }); Important Safety InformationWhat is ENBUMYST?ENBUMYST is a prescription medicine used in adults to treat swelling caused by excess fluid in the body (edema) from congestive heart failure, liver disease, and kidney disease.What is the most important information I should know about ENBUMYST?ENBUMYST is a diuretic that helps your body remove fluid. Losing too much fluid can cause dehydration, low blood volume, and increase the risk of blood clots. Blood abnormalities may include decreased salts (electrolytes), and increased nitrogen, glucose and uric acid. The risk of these abnormalities is higher in elderly people, those using higher doses, or those who do not get enough electrolytes by mouth.You should not use ENBUMYST if you have severe electrolyte loss. Tell your healthcare provider if you experience unusual thirst; dizziness or lightheadedness; weakness or tiredness; fast heart rate; dry mouth or tongue; sudden pain; redness or swelling in your joints; pain, swelling, redness, or warmth in your leg; shortness of breath or fast breathing; high blood sugar; dark urine; pale, tight, cool or clammy skin; muscle cramps; confusion.Do not use ENBUMYST if you have low or no urine production or are allergic to bumetanide or to any of the ingredients in ENBUMYST.Before using ENBUMYST, tell your healthcare provider if you have low electrolytes, are on a low-salt diet, have diarrhea, diabetes, nasal problems such as a runny or stuffy nose or polyps, a history of nasal injury or surgery, are or plan to become pregnant, are or plan to breastfeed.Tell your healthcare provider about all the medicines you take, including prescriptions, over-the-counter medicines, vitamins, and herbal supplements.ENBUMYST may cause serious side effects, such as worsening kidney function and ringing in the ears or hearing loss.The most common side effects of ENBUMYST include dehydration, headache, muscle cramps, dizziness, low blood pressure, nausea, and abnormal brain functioning with certain liver problems.These are not all the possible side effects of ENBUMYST. Talk to your healthcare provider for more information.Call your healthcare provider for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.US-ENBU-2600110 googletag.cmd.push(function() { googletag.display('JGFI_Article3_300x250'); });
Following the Science
Robert Royal: True science and faith complement each other by recognizing higher orders of reality.
Columbiana County Health District approve first reading of food service fees
LISBON — The proposed food service fees for next year through the Columbiana County Health District appear to be staying the same or decreasing from this year’s fees, with two more readings required for passage. The county health district board held first reading on the proposed fees on Wednesday, along with first reading on environmental […]
Joan Crawford’s biggest rival wasn’t who you think: Inside the ‘Baby Jane’ star’s cattiest feud
Teeth marks, bruised egos, and knitting needles: The new book ‘Jungle Red’ goes inside the catty Joan Crawford movie that makes ‘Baby Jane’ look tame.
Ex-Spur Jeremy Sochan becomes a Legend
The Dallas Legends used the top pick in Saturday's G League draft on Sochan, who will look to salvage an NBA career that has not gone as expected for the former lottery selection.
Primark's Business Doesn't Make Sense
In a world where fast fashion giants like Shein, Zara, and H&M drop thousands of new styles every day — and rake in billions through e-commerce — Primark is doing the unthinkable: thriving with zero online shopping. So what gives?*Want to Know the 5 Trends Changing Modern Retail? Find Out Here:* 🔗 https://clickhubspot.com/d13ac2In this video, we take you inside Primark’s weirdly brilliant business model — a model that’s stuck in the past on purpose. From warehouse optimization and floor-ready freight shipments to why the pandemic didn’t push them online, we unpack how this low-cost retail giant has managed to defy digital norms… and make it work.This isn’t just about one brand. It’s a story about modern retail expectations — and what it actually takes to meet (or reject) them.Subscribe to The Hustle:🔗 https://clickhubspot.com/vu3lGet the 5-minute newsletter keeping 2M+ innovators in the loop🔗 https://clickhubspot.com/3klnAbout HubSpot: HubSpot is a customer platform that provides education, software, and support to help businesses grow better. The platform includes marketing, sales, service, commerce, operations, and website management products that start free and scale to meet our customers’ needs at any stage of growth. Today, thousands of customers around the world use HubSpot’s powerful and easy-to-use tools and apps to attract, engage, and delight customers.#TheHustle #HubSpot
Santa Ynez Tribal Health Clinic to Salute Veterans with Free Dental Services at Annual 'Veterans Smile Day' Event
Credit: Courtesy SANTA YNEZ, CA – October 21, 2026 – The Santa Ynez Tribal Health Clinic (SYTHC) will salute veterans with free dental services at its
Nico Williams publicly disavows his agent over Barcelona transfer claims
Barcelona’s long and drawn-out pursuit of Nico Williams has become one of the more familiar sagas of recent transfer windows.The Athletic Club winger ultimately opted to stay at San Mames, snubbing ...
Giants at Texans live game discussion for Week 7
We, who are about to watch Texans football, salute you.
2 political experts question Chicago Mayor Brandon Johnson's tax proposals for 2027 budget
ESMO: Roche touts ‘convincing’ phase 3 KRAS data after win over rivals
Roche has shed more light on its investigational KRAS G12C inhibitor's phase 3 victory over Amgen’s Lumakras and Bristol Myers Squibb’s Krazati. The open-label Krascendo 1 trial enrolled 338 people with previously treated KRAS G12C-mutated non-small cell lung cancer (NSCLC). Patients who had already received a KRAS G12C inhibitor or pan-KRAS/RAS inhibitor were excluded from the trial. Participants received either divarasib once daily, Lumakras once daily or Krazati twice daily. Roche announced back in July that divarasib had demonstrated statistically significant improvements in progression-free survival (PFS) and overall survival (OS), meeting the trial’s primary and key secondary endpoints. But the Swiss pharma had been holding back the detailed data until now. At the European Society for Medical Oncology (ESMO) Congress in Madrid, Roche revealed that median OS for the 167 patients who received divarasib was 17.7 months, compared to 12 months for the 171 patients who received Lumakras or Krazati. The benefit was similarly clear when it came to median PFS, which stood at 9.8 months versus 5.7 months, respectively. A total of 44% of patients receiving divarasib were alive without disease progression at one year, compared to 24% of the control group, according to Roche’s presentation. It was a similar story for the objective response rate, which came in at 58% for divarasib versus 32% for the control group, while median duration of response was 11.9 months versus 6.9 months. Stefan Frings, M.D., Ph.D., deputy chief medical officer at Roche Pharma, told Fierce that the data made for a “very comprehensive, strong package, which should be convincing to health authorities.” “It’s an important advance for patients with lung cancer,” Frings said in an interview at a Madrid hotel during the conference. “It's a second-line setting, and patients who receive divarasib benefit compared to the current first-generation KRAS G12C inhibitors by having far longer overall survival,” he continued. “They live longer. They have better progression-free survival, better response rates, and with a safety profile which is—if [anything]—even better,” he said. According to Roche, 4.8% of patients receiving divarasib discontinued treatment due to treatment-related adverse events, compared to 11.7% in the control group. Serious treatment-related adverse events were also less common with divarasib, at 7.8% versus 15.2%. Roche’s confidence in divarasib had been building even before this phase 3 success. The candidate had already shown better potency and selectivity than the incumbent KRAS G12C inhibitors Krazati and Lumakras in preclinical tests. After cross-trial comparisons suggested that the edge translated into better clinical outcomes, Roche axed a study comparing divarasib to the chemotherapy docetaxel and went toe-to-toe with Lumakras and Krazati. “We designed the drug on purpose with higher potency and better selectivity,” Frings explained. “So, based on preclinical models, we clearly knew it would be superior to the first generation.” “It’s honestly not so frequent that pharma companies go head-to-head,” he added. “But if you want to make a point, if you want to convince payers, prescribers and patients … then a head-to-head win is rather rewarding.” While Amgen and BMS reached the regulatory finish line first for KRAS G12C-mutated, locally advanced or metastatic NSCLC in 2021 and 2022, respectively, they have struggled to capitalize on their head start. Krazati brought in $55 million for BMS in the second quarter, while Lumakras delivered $111 million to Amgen. For its part, Roche is aiming for peak divarasib sales of 1 billion to 2 billion Swiss francs ($1.2 billion to $2.5 billion), according to Frings. The Big Pharma is currently recruiting patients into a phase 3 trial comparing divarasib plus Keytruda against Keytruda plus chemotherapy in previously untreated advanced or metastatic nonsquamous KRAS G12C-mutated NSCLC. Roche has previously suggested that sales in metastatic disease would account for most of the forecast. Frings was tight-lipped on the exact timeline for a regulatory filing but said the Swiss pharma is “certainly keen to get this to as many patients as possible around the world.” Roche has more RAS drugs coming up behind divarasib. The pharma has already launched phase 1 trials of a pan-RAS inhibitor called RG6505 and a KRAS G12D inhibitor dubbed RG6620 in solid tumors. Roche’s partner Chugai Pharmaceutical is also testing a pan-KRAS inhibitor called AUBE00. Roche has made a “deliberate effort” to test a range of RAS drugs, Frings said. “If you have many rare mutations and you are scrambling to find sufficient patients, a pan-RAS inhibitor makes a lot of sense,” he explained.
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