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Comics accuse SiriusXM of booting middle-class comedians
The last time radio had this much effect on standup comedy, Johnny Carson was hosting late night.
AMC Entertainment Holdings (AMC) Shares Just Moved, So What Is Driving Attention Now?
AMC Entertainment Holdings (AMC) has just refinanced about $3.97b of existing borrowings, rolling them into new first and second lien facilities and notes that run out to 2031 and beyond. The refinancing arrives after a volatile stretch for AMC Entertainment Holdings, with the share price at $2.95 and a 90-day share price return of 54.45%, alongside an 83.23% year-to-date gain that points to building short-term momentum, despite a weaker 3-year total shareholder return of 70.26% and a 5-year...
Former Bengals teammate makes interesting Jordan Battle comments
Now former Bengals players have weighed in on the Jordan Battle debate.
Jim Phillips: ACC does not have ‘unanimity’ on Protect College Sports Act
With the Protect College Sports Act heading to the House of Representatives, the ACC has become a key part of the conversation. Four school presidents from the conference penned a letter to House Speaker Mike Johnson (R-La.) requesting changes to the conference realignment provision last week. Speaking at ACC Tipoff on Tuesday, commissioner Jim Phillips […]
How combining science and community knowledge could shape coral reef conservation in Indonesia
Coral reefs in Indonesia’s Spermonde Archipelago are under pressure from both natural and anthropogenic activities. Researchers from Hasanuddin University assessed reef conditions across three islands using underwater photography and drone surveys, while also gathering local perspectives on reef conditions and restoration. They found greater live coral cover in clearer waters but limited community readiness to participate in conservation efforts, suggesting that training and institutional support could strengthen local communities’ role in protecting these natural treasures.
More than 1,000 students explore STEM careers through hands-on experiments at Science Museum
More than 1,000 seventh graders are testing robotics, electricity and virtual reality at Science Museum Oklahoma's Innovation Week.
TROY College of Science and Engineering students create Dean's Student Advisory Council
Students within the College of Science and Engineering now have the opportunity to make a lasting impact on college initiatives, improvements and student experiences thanks to the creation of the Dean’s Student Advisory Council.
Health department requests F-16 crash response grant for exposure testing, staffing
The Grand Traverse County Health Department is requesting approval of a $134,145 grant to cover the response to the F-16 crash.
11 Prime Day Cycling Deals Actually Worth Buying in 2026
Navigating Amazon's cynical retail holiday is an exhausting chore. Here are 11 genuine 2026 discounts on cycling tech, smart trainers, and nutrition from Wahoo, Garmin, and GoPro that I recommend at full price.
All 'Unsupervised Science' FBC testing facility locations in Control Resonant
How to shut down all FBC testing facilities
October 2026 Satellite Puzzler
Your challenge is to tell us the location of the satellite image and why it is interesting.
New agriculture scouting business takes off
Delmarva farmer Nichole Krambeck uses drones and soil DNA testing at Insight Ag Scouting to cut costs and boost crop yields.
Trump Voters Think Ken Paxton Is “Disgusting” and “Bad.” These Ads Aren’t Helping.
You may have seen some weird, off-putting ads from a pro-Paxton group over the weekend. What are they trying to accomplish?
Xbox CEO Asha Sharma speaks at internal town hall — Discussing Xbox Series X|S as 'core,' Helix as a family of devices, boosting Game Pass, and more
EXCLUSIVE: In a recent town hall with Microsoft gaming staffers, Xbox CEO Asha Sharma described how Xbox was in "free fall" declines before this year's big restructure.
Ousting a Republican from a Kamala Harris district may not be as easy as it sounds
Mike Lawler is one of the most vulnerable Republicans in Congress this election cycle, one of only three representing a district that Kamala Harris won in 2024.
Packers working out former Falcons cornerback Cobee Bryant
The Packers are hosting a workout for former Falcons cornerback Cobee Bryant on Tuesday.
City of Laredo kicks off political forums for 2026 elections
The City of Laredo is kicking off “Laredo Votes 2026” Tuesday, Oct. 6, hosting political forums for City Council Districts 1 and 6.
Pacers Given Interesting Win Total Despite Tyrese Haliburton Return
The Indiana Pacers have been given an interesting win total prediction entering the new NBA season.
Week 5 fantasy wide receiver rankings: Top WR streamers, starts
After missing two games with a strained hamsting, Houston's Nico Collins returned with a bang (and two TDs). Where does he rank among WRs this week?
Want To Know If Someone Likes You? Science Suggests A Key Vocal Feature Can Reveal Who We Like, And Influence Who Likes Us
Interestingly, in works differently for long- and short-term relationships.
From Amoral Politics to Immoral Politics: The Influence of the Trump Administration
Azmi Bishara examines the impact of sustained exposure to the rhetoric and practices of US President Donald Trump’s administration on public moral values and ethical norms, in the United States and elsewhere, distinguishing between amoral politics and the justification of immoral political discourse and conduct.
Paramount-WBD deal closes; here are top quant-rated entertainment stocks
Paramount Skydance–WBD merger reshapes entertainment—see 20 top quant-rated movies & broadcasting stocks (AMC, DIS, NFLX, ROKU).
Sphere Entertainment stock price target lowered to $125 by StoneX
Sphere Entertainment stock price target lowered to $125 by StoneX
Manchester aerospace company expands casting business with new overseas acquisition
Pursuit announced it closed on the deal to buy Creasey Castings in August, the company’s sixth acquisition since 2023.
Broncos Offense Has Been Exhausting To Watch So Far
The Denver Broncos haven't been able to score or move the football, and it's getting tiring.
Remaking scents: could fragrance tech help take pressure off endangered plants?
Firms working on reproducing compounds without need for repeated harvesting but conservationists are sceptical
How ‘Little Shop of Horrors’ found the perfect voice for Audrey II
‘Little Shop of Horrors’ casting director Margery Simkin shares the story of how she found the perfect voice for Audrey II.
Sanford Health Fargo offering flu shots at clinics, hosting vaccine events including ‘Boo to the Flu’
Sanford Health Fargo is now offering flu vaccinations to patients 6 months and older at all Fargo metro area primary care clinics.
New Report: 400+ Global Life Science Leaders Bullish Despite Market Uncertainty
As AI usage takes shape and market pressures persist, CRB's Horizons: Life Sciences 2026 report explores how manufacturers are investing in facilities,...
John Beam made a difference. The Chronicle wants to hear about Bay Area coaches who helped you
For the John Beam Community Action Award, we want to hear from readers about the local coaches who have made a lasting impact on the lives of student-athletes and communities.
Sun Life research reveals the ripple effect behind small business success
As Canada's small businesses navigate a rapidly changing business environment, new research from Sun Life shows that success is about more than growing revenue. It's about building resilience. When owners feel confident in their ability to weather challenges and plan for the future, they're more likely to invest in their employees, strengthen their businesses and create lasting impact for the people who depend on them. The findings align closely with how Sun Life supports small business owners,
Stocks making the biggest moves premarket: Constellation Energy, Option Care Health, Lennar, P&G and more
These are the stocks posting the largest moves in early trading.
FT and Standard Chartered Book of the Year Award 2026
Contenders include titles on weight-loss drugs, AI weaponry and forecasting
FT and Standard Chartered Book of the Year Award 2026
Contenders include titles on weight-loss drugs, AI weaponry and forecasting
I’m an American in Denmark. I moved here excited to have a better work-life balance—but I kept resisting it
Brooke Black says moving to Denmark from the U.S. didn't cure her workaholism. It took her years to learn that rest and ambition were not mutually exclusive.
France student protests roil politics ahead of elections
Analysts expect unrest to intensify after a teenager’s hand was blown off by a riot police sting grenade.
Citizens reiterates Sphere Entertainment stock rating on venue expansion outlook
Citizens reiterates Sphere Entertainment stock rating on venue expansion outlook
As Halo Moves to Activision, Halo Studios Writers Tease What Might Have Been
Following the launch of Halo: Campaign Evolved, Halo Studios has put out a blog post detailing plans for the future of Master Chief’s story. It’s an interesting look at where the series might have gone, prior to the recent announcement that Activision is now the shepherd of the Halo series.
AMC Entertainment Refinances With $2.0B Notes, $850M 1L, $1.12B 2L; Retires Prior Debt
AMC Entertainment Holdings executed a broad refinancing that includes $2.0 billion of 8.875% first lien notes due 2031, an $850 million first lien term loan maturing 2031, and a $1.12 billion second lien term loan due 2033. Proceeds were used to repay and terminate certain existing facilities and t…
BTIG cuts Sphere Entertainment stock price target on lower revenue outlook
BTIG cuts Sphere Entertainment stock price target on lower revenue outlook
California governor condemns Trump's 'let 'em take Los Angeles' comments
By Steve Gorman LOS ANGELES, Oct 5 (Reuters) - California Governor Gavin Newsom has lashed out at President Donald Trump for remarks to a crowd of his supporters in Nebraska's farm belt suggesting
Beauty Brands Are Coming for Sports—and They Want More Than Exposure
Beauty presents a distinct opportunity because brands within the category are decidedly investing to reach female fans. The industry also has an $11.4 billion global advertising budget and has historically spent little with rights owners and holders. Rights owners and holders must offer beauty brands more than visibility. However, properties that can successfully pair access to the demo with engaging on-site activations and measurable gains in awareness, purchase intent, and/or sales should be p
Before Saying Yes to the Medical Test, Know the Risks and Benefits
Tests like full-body scans marketed directly to consumers are pitched as a way to detect diseases early and establish a baseline of health markers. But there are financial, physical, and psychological risks to all medical tests — and in some cases, not getting a test could be better for your health.
Ken Paxton’s secret weapon: Ted Cruz
Cruz is boosting Paxton with fundraising and advice as he mulls his own political future.
NBA 2K25 servers to shut down on December 31, single-player story mode will become unplayable
Decision to sunset 2K25 follows 2K's trajectory of delisting NBA games over the course of two years
A Patient and Doctor Weigh the Pros and Cons of Genetic Testing
Genetic testing, a heart scan and a blood test gave Ron Carr unexpected answers about Alzheimer’s and cardiovascular risk.
New WVU Bowl Projection Comes With a Fascinating Twist
The West Virginia Mountaineers have lost consecutive Big 12 games, but one new bowl projection gives fans an interesting reason to keep thinking about what could still be waiting at the end of the season. WVU fell to 3-2 following its 45-42 loss to Iowa State on Oct. 3. Rich Rodriguez’s team is now 0-2 in […] The post New WVU Bowl Projection Comes With a Fascinating Twist appeared first on HEAVY.
Apple Announces iPhone Duo Apps Can Now Be Submitted to App Store
Apple today announced that apps optimized for the iPhone Duo can now be submitted for App Store approval, ahead of the foldable device launching on Friday, October 23. While existing App Store apps will automatically run on the iPhone Duo, only apps built with the iOS 27.1 SDK or later can dynamically resize to fill the entire space of the inner display, whereas unoptimized apps will have black borders.
New Editorial Calls for Investing in Hospital Nursing Workforce to Address Health Impacts of Extreme Heat
Hospitals should make nurse staffing and supportive nurse work environments a core part of extreme heat emergency preparedness, according to a new editorial from Penn Nursing’s Center for Health Outcomes and Policy Research (CHOPR), as record-breaking temperatures and heat-related emergency department visits continue to rise across the United States. The editorial appears in Public Health Nursing.
Dolphin entertainment CEO William O’Dowd IV buys $4,855 in stock
Dolphin entertainment CEO William O’Dowd IV buys $4,855 in stock
Olivia Dean song lifted from Bill Withers hit, complaint alleges
A complaint recently filed in California alleges that Grammy winner Olivia Dean's song 'I've Seen It' lifts from Bill Withers' lasting hit 'Just The Two of Us.'
Cresset Aims for $13.1B Trust Business with NAT Deal
Cresset would fold its existing $5.5 billion trust division into the $7.7 billion NAT platform while continuing to grow through clients, acquisitions.
Legends Radio spotlights JB Berkow’s lifelong art passion
JB Berkow is the founder of Benzaiten Center for Creative Arts in Lake Worth Beach. LEGENDS RADIO / COURTESY PHOTO This week's Legends Radio Local Artist Spotlight shines on accomplished artist and passionate advocate for the arts, JB Berkow. For more than five decades, JB Berkow has dedicated her life not only to creating art but also to making sure art has a place to thrive. Her work has been exhibited throughout the country in galleries, museums, and universities, and is held in permanent collections, including the Vatican’s Contemporary Art Collection in Italy, Boston University, and Palm Beach International Airport. Her passion for supporting other artists began early. At age 26, Berkow founded Touchstone Gallery in Washington, D.C., which became a highly successful cooperative gallery. She later brought that same entrepreneurial spirit to South Florida, founding Frenchman’s Art Gallery and Studios in Juno Beach in 1995. She opened Rosetta Stone Fine Art Gallery in 2003. In 2015, JB took her commitment to arts education even further by founding the nonprofit Benzaiten Center for Creative Arts. The 15,000-square-foot facility in Lake Worth Beach is home to Florida’s largest publicly accessible glassblowing hot shop and offers instruction in glassblowing, fusing, flameworking, and glass casting. The center also provides free classes to approximately 1,000 underserved children and young adults with disabilities each year. Its “Fragments Reimagined” art therapy program for veterans with PTSD recently received a $100,000 Impact 100 grant. In addition to her work as an artist and advocate, Berkow has authored four books, including Shades of Love and What They Didn’t Teach You in Art School. For JB, art has always been about more than creating something beautiful. It’s about opening doors, inspiring others, and making creativity an important part of life.That is why JB Berkow is in this week’s Legends Radio Local Artist Spotlight.
Byram business owner relocates man experiencing homelessness brought into city
A Byram entrepreneur recorded himself assisting a man experiencing homelessness by offering him a ride and relocating him outside the city.
MSSM to Host Public STEM Night
The Maine School of Science and Mathematics in Limestone is hosting a STEM Discovery Night tonight.
Fall Preview with Entertainment Correspondent Mike Marra
Airdate: October 5th, 2026 Leoni Township Update with Administrator Mike JesterOctober 5, 2026City Treasurer Hosting Town Hall Meeting SeriesOctober 5, 2026Tecumseh Appleumpkin Festival This WeekendOctober 5, 2026Fall Preview with Entertainment Correspondent Mike MarraOctober 5, 2026Disney’s Frozen Premieres Thursday at The SaukOctober 5, 2026Alison McGlynn & Lilly Hayworth, The Annex Collective SalonOctober 5, 2026John Spink, Nite…
Budding food scrap businesses want your coffee grounds and eggshells
Composting leftover coffee grounds, eggshells and carrot tops is a way to reduce the amount of food waste that goes into landfills, where it produces the potent greenhouse gas methane
Kasson-based non-profit hosting mental health fair, documentary screenings today
The fair will take place at Austin High School.
Bladen Community College to host “So You Want to Start a Small Business” class and preview Pitch It Bladen 2027
The Small Business Center at Bladen Community College invites aspiring entrepreneurs to attend “So You Want to Start a Small Business” on Tuesday, Oct. 13, 2026, from 6:00 p.m. to 8:00 p.m. in Building 14, Room 104. This class will help participants explore what it takes to become an entrepreneur and take the first steps toward turning a business idea into reality.Participants will explore the entrepreneurial mindset and consider whether they have the interests, characteristics, motivation and willingness to take on the challenges of business ownership. The class will encourage attendees to examine their personal goals, expectations, strengths and readiness to pursue entrepreneurship.Attendees will also gain insight into the realities of starting and operating a small business, including the commitment, planning, decision-making and perseverance required to build a successful venture. Whether participants are just beginning to consider business ownership or already have an idea they want to pursue, this class will provide a foundation for determining their next steps.In addition to the class instruction, attendees will receive advance information about the upcoming Pitch It Bladen 2027 Business Competition, including the application form and details about the program. Individuals who are ready to move forward may submit their applications early and have the opportunity to receive advance acceptance into the program.Pitch It Bladen helps aspiring and emerging entrepreneurs develop their business ideas through structured instruction in business planning, financial management, cash-flow projections, marketing and operations. Participants work toward completing a business plan and preparing a business pitch, with the opportunity to compete for cash prizes.Last year's Pitch It Bladen program demonstrated the value of investing in local entrepreneurs by helping participants strengthen their business knowledge, develop their business plans and prepare to present their ideas. The competition showcased the creativity and potential of Bladen County's small-business community and provided participants with practical tools to move their business goals forward.Building on that success, Pitch It Bladen 2027 will provide another opportunity for local entrepreneurs to gain knowledge, build confidence and take meaningful steps toward launching or growing a business.“The Small Business Center wants to help individuals make informed decisions about entrepreneurship before they take the leap into business ownership,” said Theresa Dennison, Small Business Center director, in a press release. “This class gives participants an opportunity to evaluate whether entrepreneurship is right for them while also introducing them to Pitch It Bladen 2027 and the resources available to help them succeed.”Registration: Visit www.ncsbc.net and search for the class by name, or contact the Small Business Center at 910-879-5572 for additional information.
James Gunn dispels Wonder Woman casting rumors while roasting Frank Grillo
James Gunn addressed the Adria Arjona-Wonder Woman casting rumors by roasting DC star Frank Grillo. ‘You don’t believe he doesn’t know anything? Exhibit A.’
Your ballot, your move: Early voting starts Oct. 6
By Kevin Hendricks, nm.news — New Mexico voters can start casting ballots Oct. 6 for the Nov. 3 general election. There’s no reason to wait in line on Election Day, or to walk into the booth guessing. Early voting opens Oct. 6 at county clerk offices. On Oct. 17 it expands to more locations across […]
CAS inducts seven into Hall of Fame
The College of Arts and Sciences (CAS) inducted seven distinguished members of the CAS community into its Hall of Fame on Friday, September 18.
Will R.I. voters, elected officials continue investing in life sciences?
Rhode Island starts in a strong position and has the ingredients needed for innovation and growth. What we don’t have yet is a long-term commitment, writes the CEO of the RI Life Science Hub.
Apple Releases Third iOS 27.2 Beta
Apple today seeded the third beta of an upcoming iOS 27.2 update to developers for testing purposes, with the update coming two weeks after Apple released the second iOS 27.2 beta. Apple also seeded a new iPadOS 27.2 beta. Registered developers can download the beta updates by opting in under Settings > General > Software Update and selecting the iOS 27 developer beta. iOS 27.2 includes Apple's redesigned Health app with new Insight and Longevity tabs.
Saquon Barkley injury update: Latest on Eagles star running back
Saquon Barkley has undergone testing on his injured hamstring as the Eagles prepare to face Jacksonville in London
SI gives Oklahoma an interesting matchup in latest bowl projections
Sports Illustrated gives Sooners an intriguing matchup in new bowl picks.
The #2 Movie on Netflix Is a Thrilling Documentary About a Charismatic Serial Killer
"The Widower: 'Til Death Do Us Part" follows the twisting story of Thomas Randolph, also known as the "Black Widower," of whose six wives, four ended up dead.
Steelers Sign Super Bowl Linebacker
The Pittsburgh Steelers signed linebacker Marte Mapu to their practice squad on Monday after hosting him for a visit on […]
‘Primetime’: Is catching predators justice or just entertainment?
Rating: ★★★½ Starring Robert Pattinson, Skyler Gisondo, Merritt Wever Directed by Lance Oppenheim Rated R Release Date: Sept. 25, 2026 A man waits unknowingly inside a sting house. His eyes draw up to the sound of curtains ruffling as Chris Hansen (Robert Pattinson), host of Dateline NBC’s “To Catch a Predator,” enters flamboyantly. Hansen descends...
Sphere Entertainment options flow analysis amid an 11.6% stock drop
Sphere Entertainment options flow analysis amid an 11.6% stock drop
Anti-trans ballot measures are a political test run for the 2028 presidential election
LGBTQ+ movement leaders warn that anti-trans ballot measures in five states could become a testing ground for a broader political strategy in the 2028 presidential election.
First DLC for ‘Halloween: The Game’ Arrives October 27, Featuring a Free ‘Halloween 5’ Map
As expected, the first DLC for IllFonic's 'Halloween: The Game' will arrive just in time for Halloween on October 27.
Seattle-area businesses feel sting of ‘obscene diesel prices’
In Washington, the average cost for a gallon of diesel was around $7.37 Friday, according to the American Automobile Association, almost $2.50 more than a year ago.
The Science Behind Female-Specific Firefighting PPE
Camilla Callesen, chief designer at VIKING Fire & Rescue, and retired firefighter Kendall Taylor discuss the research, engineering, and field testing behind the VIKING VALKYRIE.
Scientists generate identical photons at the push of a button
Researchers from different universities have teamed to generate photon pairs that are 90 percent identical, helping advance quantum communications.
Why plugged-in pickle glows: Engineer burns 100-plus pickles to find answer
An engineer says glowing pickles owe their orange light to sparks igniting hydrogen near an electrode, with sodium ions supplying the color.
Scientists reveal what seven days of fasting does to the human body
Scientists found that prolonged fasting triggers major changes throughout the body, but many of the most interesting effects only appeared after about three days without food. The results suggest fasting may influence health in ways that go beyond weight loss and could eventually inspire treatments that mimic its effects.
Here’s Exactly How Often to Eat Fish to Support Brain Health, According to a Dietitian
In TODAY.com’s Expert Tip of the Day, a dietitian shares how to get the brain-boosting benefits from eating fish regularly.
UConn Scientists’ Startup Seeks to Advance Women’s Reproductive Healthcare
'Historically, women’s health has received insufficient attention in medical research and testing'
Yale School of Medicine On the Science of Childhood Anxiety, Say, Anxiety Disorders Are the Most Common Mental Health Challenges In Youth
Credit: Matt Bradbury October 5, 2026 - By Isabella Backman - Anxiety disorders are the most common mental health challenges in youth. Left untreated, they can disrupt the lives of both children and their families. The good news is that with intervention, most children will overcome these conditions. Across Yale School of Medicine, scientists are working to understand anxiety at every level, from common anxious behaviors to molecular biomarkers in the brain. They are using their findings to develop and disseminate new evidence-based treatments for childhood anxiety. Today, the go-to treatment for childhood anxiety disorders is cognitive behavioral therapy (CBT). This is a form of psychotherapy that teaches children skills for confronting anxious thoughts and helps them practice managing situations that cause anxiety. While it is the gold-standard treatment backed by considerable scientific evidence, up to 50% of children will not see sufficient benefit from CBT alone. Wendy Silverman, PhD, Alfred A. Messer Professor in the Child Study Center, co-directs the Anxiety and Mood Disorders Program alongside Eli Lebowitz, PhD, associate professor in the Child Study Center. One of their main interests is learning how to improve outcomes beyond CBT. “We’re developing cutting-edge, research-based knowledge that can reduce the suffering that anxiety causes children and their families,” says Silverman. Changing parent behavior YSM experts are investigating how to improve CBT outcomes for children by involving the parents. Silverman’s research has uncovered two main components of parent intervention that improve childhood anxiety: not enabling children to completely avoid the things that make them anxious and taking steps to enhance their autonomy. Parents may unintentionally reinforce their child’s anxiety by allowing them to avoid what makes them anxious. They also may unintentionally limit the children’s sense of autonomy by being overly intrusive. “One of the things that we take pride in is that we’ve focused on trying to understand what parents need to do, and to test our ideas and see if changing the parents’ behaviors is enhancing the effects of CBT,” Silverman says. “Our findings thus far suggest that they do." As much as CBT can be helpful, it can also be challenging to get one’s child to do the necessary steps for CBT to work. This is one important reason why Lebowitz created a novel intervention program for parents named Supportive Parenting for Anxious Childhood Emotions (SPACE). Existing intervention programs often teach parents to act as therapists for their child, such as training them on how to practice breathing exercises. “It makes sense, but this doesn’t work very well in practice,” says Lebowitz. “And part of the reason, I think, is that it’s not easy to get your kid to do things, especially if they’re not excited about doing it.” SPACE is unique because it focuses entirely on parent involvement and changing parental behavior—children are not involved in the sessions. For example, parents learn how to use supportive messages that convey confidence that their child can tolerate and manage distress. “It might sound like a parent saying to a child, ‘I get that this is really hard for you, but I know that you can handle it,’” Lebowitz says. The program also works with parents to identify the ways in which they are accommodating anxious behaviors. “We’ll pick one thing that parents are doing that is an accommodation and help them make a detailed plan for how they’re going to change that,” Lebowitz explains. Treating Anxiety in Children and Adolescents Much of the existing research on SPACE has focused on parents of children under age 14. Ongoing studies are now exploring its use with parents of older teens. “Both anxiety and accommodation can interfere with normative developmental shifts during the teen years, including increased autonomy and individuation from parents,” says Rebecca Etkin, PhD, associate research scientist in the Child Study Center. “In this sense, SPACE may be particularly well-suited for anxious teens and their parents. We want to see whether it is effective during this distinct developmental window.” Unfortunately, many families in need of CBT face barriers, including limited availability of services and geographic constraints. One way to improve access is digital interventions. Silverman and her team are developing an evidence-based digitized intervention program for parents that they can access directly from their computer or smart phone. “The work we’re doing will be one of the very few parent interventions that is digitized and importantly tested for effectiveness,” she says. Creating interventions for anxiety-related challenges Silverman and Lebowitz recently received a generous gift to develop and test other interventions that help parents reduce other child anxiety-related behavioral and emotional difficulties, such as restrictive eating and unexplained somatic symptoms. One of these projects in particular focuses on understanding the risks of social media and its potential benefits, including offering a sense of connection. “A lot of research has focused on the idea that social media is harmful and the less of it the better,” says Lebowitz. “But we actually see is that this is not quite right—there are negatives, but there are also positives. So, we’re trying to get a little bit more nuanced of a picture.” The team is working with teens with social anxiety and their parents over an extended period to better understand their social media habits and how their anxiety levels affect engagement with different platforms. The teens will answer questions sent to an app on their phones about mood and social media usage in an effort to capture emotional responses as they unfold. “We hope to develop interventions that can help make the best of social media while protecting against the more problematic effects,” Lebowitz says. The brain’s role in anxiety Researchers are also testing therapies to address anxiety at the neurological and molecular levels. In collaboration with Dylan Gee, PhD, professor of psychology in Yale's Faculty of Arts and Sciences, and Hilary Blumberg, MD, John and Hope Furth Professor of Psychiatric Neuroscience at Yale School of Medicine, Lebowitz and Silverman are using brain imaging to identify changes in a child’s brain before and after parents enroll in SPACE. In one study, children viewed anxiety-inducing images while undergoing magnetic resonance imaging (MRI); the researchers conducted scans with and without the children’s parents nearby. Before SPACE, children’s brains were better able to activate the regulatory circuitry needed to turn off an anxious response when their parents were nearby. But after SPACE, children could activate this circuitry even without the parent around. “As parents work on gradually reducing some of their accommodations, you can see a child get better at regulating their own fear system in the brain,” Lebowitz says. “It’s remarkable.” Research into the molecular underpinnings of anxiety can also inform new childhood anxiety treatments. In a recent study, Lebowitz, Silverman, and Flora Vaccarino, MD, Harris Professor in the Child Study Center, discovered that a protein known as fibroblast growth factor 2 (FGF2) could be protective from the toxic effects of stress. FGF2 levels in children and their parents were linked to the children’s risk of developing anxiety and depression, the study showed. The findings could help explain why some children who are exposed to early life trauma such as poverty or abuse are more prone to developing mental health disorders. And FGF2 could be a target for treatment. “This is very novel because it starts to give a clue to what is the molecular chain that connects those lived experiences to the actual psychological outcomes,” Lebowitz says. New ways to study and treat childhood anxiety Michael Crowley, PhD, associate professor in the Child Study Center, collaborates with Silverman and Lebowitz to study the role that attention plays in development and maintenance of childhood anxiety. There is a large body of research that shows that anxious children, like anxious adults, are prone to focus on threatening stimuli such as angry faces compared with neutral faces. This has led to innovative interventions that involve attention retraining. The idea is that if experts train children to look away from threatening stimuli, it may reduce their anxiety—especially children with social anxiety who are most prone to attend to threats. The researchers have just completed a clinical trial for attention retraining with 10- to 14-year-olds with social anxiety disorders and are currently analyzing the findings. Besides this innovative attention retraining research, as Crowly notes, “I like to design tasks that are engaging to kids,” Crowley says. “My goal is to assess something without the kids knowing what we are assessing.” With this goal in mind, Crowley has created a virtual game, named Boom, to study threat processing in children with anxiety disorders. The game is similar to that of hot potato—the child and three digital players take turns virtually passing a ball to each other’s gloves. At some point, the ball turns into a bomb, and as the bomb lands in each player’s glove, the outline of the glove turns yellow. The goal is to avoid having the bomb go off in your glove. What isn’t obvious is that the game is designed to measure different types of threatening stimuli, both ambiguous and direct. In the game, the direct threat occurs as the bomb is traveling towards your glove. The ambiguous threat is the yellow outlined glove as it is unknown where the bomb will travel next. While children play the game, Crowley’s team measures their brain activity using electroencephalography (EEG). The researchers have discovered that in kids with anxiety, the brain reacts more strongly to ambiguous threats than it does in their peers, but less strongly to direct threats. They believe that the initial abnormally large brain response to not knowing where the bomb is going impairs the brain's ability to properly respond when the threat is actually traveling the child’s way. “The brains of children with anxiety are unable to differentiate between threats you need to do something about and those that are not your problem.” Michael Crowley, PhD, develops innovative games for studying anxiety in children and adolescents.Credit: Matt Bradbury Based on these insights, Crowley hopes to study whether interventions like attention training could restore appropriate threat processing. Crowley’s team is also working on a test called the Balloon Risk Avoidance Task, which evaluates risk-taking and avoidance behaviors. It features a digital balloon that is full of air and about to burst. Kids have six seconds to let air out of the balloon. The more air they let out, the less risk they face that the balloon will pop. But at the same time, the balloon becomes less valuable as it deflates. “The more air you keep in the balloon, the more points you get,” Crowley explains. So far, the researchers have found that when the balloons pop unexpectedly, teens with social anxiety show distinct brain responses. Studying these responses can help psychologists understand the underlying pathways driving the various manifestations of anxiety. The genetics of anxiety When Thomas Fernandez, MD, associate professor in the Child Study Center and of psychiatry, was still in training, there was a lot of excitement about understanding the genetics associated with autism spectrum disorder. Since then, scientists have identified around 250 genes associated with autism. The genetic contribution to anxiety disorders, on the other hand, has historically received less attention. Anxiety is less heritable than autism, but the genetic contribution for anxiety disorders that emerge in childhood may be higher than for anxiety disorders overall. While scientists estimate the heritability of anxiety disorders in general to be around 30% to 50%, some studies suggest higher heritability for certain childhood-onset anxiety presentations. “I saw firsthand how researchers in the field went about finding vulnerability genes for autism,” Fernandez says. “So, we’re using a very similar playbook for childhood anxiety.” “I saw firsthand how researchers in the field went about finding vulnerability genes for autism. So, we’re using a very similar playbook for childhood anxiety.” Thomas Fernandez, MD Associate Professor In the Child Study Center and in Psychiatry Now, Fernandez and Emily Olfson, MD, PhD, assistant professor in the Child Study Center, are studying children and their parents to identify genetic changes that are present in the child but not the parents, known as “de novo mutations.” “All of us have some de novo mutations—maybe about 50 to 100 sprinkled throughout the genome,” Olfson says. “But when they occur within the coding regions of genes, they can be really disruptive.” Previous research shows that people with autism have higher rates of damaging de novo mutations than the general population. In 2022, Olfson, Lebowitz, Silverman, and Fernandez published a study on 68 children and their families that found that children with anxiety had similarly high levels of these mutations. Studying de novo mutations can help point the researchers to where they should be looking for genes associated with anxiety. “The end game is using the genes to steer us toward the right part of biology that we can then target to come up with better treatments,” Fernandez says. Building on those findings, the team is now studying more families to better understand how these de novo mutations, along with other genetic and environmental factors, shape pediatric anxiety disorders. They recently received a National Institutes of Health grant to enroll 750 new families over the next five years. Olfson is the principal investigator, with co-investigators Lebowitz, Fernandez, Silverman, and Shuangge Steven Ma, PhD, department chair and professor of biostatistics at Yale School of Public Health. Neurodevelopment, Risk Genes, and Mental Health Conditions - The Olfson Lab Joel Gelernter, MD, Foundations Fund Professor of Psychiatry, is interested in how different anxiety disorders differ genomically. “We are studying social phobia, panic disorder, and generalized anxiety disorder, working to understand why people differ in their risk to these specific anxiety disorders and evaluating various risk factors,” he says. Gelernter was recently involved in one of the largest studies to date of the genomics underlying anxiety disorder. The study included around 122,000 people with anxiety disorders and around 730,000 without. It found that some genetic differences associated with anxiety were linked to signaling that helps reduce overactivity in the nervous system. Many anxiety medications available today work by targeting this process. “It’s nice when the biology that you get out of a large genome-wide study ratifies things that we already know because that can help increase confidence in further findings from the study,” Gelernter says. Uncovering the neurobiology of psychiatric disorders John Krystal, MD, Robert L. McNeil, Jr. Professor of Translational Research and chair of the Department of Psychiatry, is interested in the neurobiology of psychiatric disorders, including post-traumatic stress disorder (PTSD), of which anxiety is a major symptom. In the late 1980s, Krystal’s team discovered that the drug yohimbine activated symptoms in patients with PTSD. “This was the first time we could link a specific biological mechanism to the symptoms of PTSD,” Krystal says. At the time, he adds, this finding was highly controversial. “A lot of people felt that PTSD was a purely psychological syndrome that didn’t have an underlying biology.” Since then, Krystal has dived deep into understanding the neurobiology of PTSD to learn how to better treat it. His team is evaluating the use of ketamine and psychedelics. These would be among the first treatments to be developed specifically for PTSD. They may also be applicable for other disorders including anxiety disorders, Krystal adds. An important gap in PTSD treatment is the absence of biological tests that inform how to best help patients manage their PTSD symptoms. A doctor doesn’t diagnose cancer based on how they feel. Rather, they use tests of the biology of the cancer to determine the best course of treatment. “And we can’t do that in any psychiatric disorder other than Alzheimer’s disease,” Krystal says. “But now we are building a foundation for this approach to the treatment of anxiety disorders for the first time.” Source: Yale School of Medicine
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