SCROLL NEWS / DISCOVERY

Search headlines

Find the stories shaping the conversation.

Search mode
Refine results
Active filters Keyword All time

Results for " Chi " 28,362 found 🔀 AI-powered Shuffle

Frighteningly fun films for Halloween

With autumn finally here and spooky season in full swing, what better way to celebrate than by watching a fun, creepy film? Whether you prefer horror films or nostalgic childhood

valpotorch.com logo
Oct 26 • 1:00 AM EDT • Entertainment • valpotorch.com
‘End game’: Taylor Swift and Travis Kelce mocked by opponent

The Seattle Seahawks handed the Kansas City Chiefs their first loss of the season on Sunday night, and they made sure to rub it in afterward by trolling newlyweds Travis Kelce and Taylor Swift. After their 20-3 win on Sunday Night Football, the Seahawks posted a Swift-themed troll on social media, sharing a friendship bracelet…

sports.yahoo.com logo
Oct 26 • 12:40 AM EDT • Sports • sports.yahoo.com
☹️ Negative (-5%)
sad
100%
Patrick Mahomes Earns New Nickname From Kansas City Chiefs
sports.yahoo.com logo
Oct 26 • 12:14 AM EDT • Sports • sports.yahoo.com
Bears vs. Seahawks odds: Opening lines for Week 8 matchup

The Chicago Bears and the Seattle Seahawks are both coming off prime-time Week 7 wins, and they’ll face each other under the lights in Week 8 on Monday Night Football. The (5-2) Bears knocked off the New England Patriots 30 to 24 on Thursday Night Football, while the (4-3) Seahawks just won 20 to 3 […]

sports.yahoo.com logo
Oct 26 • 12:13 AM EDT • Sports • sports.yahoo.com
China's Rise in Science as a Source of Strategic Power

China is on course to lead the world in research and development, a shift with direct consequences for technological competition and the balance of global power. That is the conclusion of a news feature by Xiaoying You in Nature, published on October 14, 2026. The scale of the change is striking. In 1978, researchers in […]

sldinfo.com logo
Oct 26 • 12:09 AM EDT • Science • sldinfo.com
Understanding Gastroparesis

Hunting for a diagnosis — and treatment — when your stomach won’t empty.

chicagohealthonline.com logo
Oct 26 • 12:03 AM EDT • Health • chicagohealthonline.com
Can teaching people more about science increase public trust?

We hear about science outreach efforts in Cincinnati designed to spur interest — and the role moms play in shaping science policy.

wvxu.org logo
Oct 26 • 12:00 AM EDT • Science • wvxu.org
That's Entertainment: Week of 10/26/26

Music

leadertelegram.com logo
Oct 26 • 12:00 AM EDT • Entertainment • leadertelegram.com
Palisades setbacks put nuclear safety culture in the underwriting spotlight

A regulator's warning over a fearful workplace at Michigan's restarting reactor lands just as data-center demand pulls more insurers toward atomic risk

insurancebusinessmag.com logo
Oct 25 • 11:59 PM EDT • Business • insurancebusinessmag.com
Luke Bryan’s quarterback son commits to Georgia

"Most Friday nights look better under neon or stadium lights,” but country singer Luke Bryan better get used to watching his football on Saturdays.

sports.yahoo.com logo
Oct 25 • 11:49 PM EDT • Sports • sports.yahoo.com
West Greene Insurance & Tax Service joins GCP

Click here to view this article from greenevillesun.com.

greenevillesun.com logo
Oct 25 • 11:30 PM EDT • Business • greenevillesun.com
😐 Neutral (0%)
Ewa Beach shooting survivor overcomes another health scare

Three years after surviving a gunshot to the head, Richianna DeGuzman is heading back to rehab following a week-long stay in the ICU.

hawaiinewsnow.com logo
Oct 25 • 11:24 PM EDT • Health • hawaiinewsnow.com
😐 Neutral (0%)
LAFC clinch Audi 2026 MLS Cup Playoffs spot

By MLSsoccer staffLAFC have qualified for the Audi 2026 MLS Cup Playoffs, clinching their spot following a 2-2 draw vs. arch-rivals LA Galaxy on Sunday.With two regular-season matches left, the Black ...

sports.yahoo.com logo
Oct 25 • 11:20 PM EDT • Sports • sports.yahoo.com
Pocatello business owner helps families impacted by Extreme Rush closure still get their night of fun

POCATELLO — When Extreme Rush suddenly closed and families were left holding gift cards meant for birthdays and special nights out, it didn’t sit right with Sloan Dalley.

idahostatejournal.com logo
Oct 25 • 10:36 PM EDT • Business • idahostatejournal.com
Travis Kelce’s Physical Appearance Turns Heads Before Seahawks Game

Kansas City Chiefs star Travis Kelce made waves with his appearance in Seattle before Sunday's game against the Seahawks. The post Travis Kelce’s Physical Appearance Turns Heads Before Seahawks Game appeared first on HEAVY.

sports.yahoo.com logo
Oct 25 • 10:31 PM EDT • Sports • sports.yahoo.com
What to know about China’s plenum as Xi seeks stronger Communist Party discipline

HONG KONG (AP) — China's political leaders and elites begin a four-day meeting Monday to discuss strengthening the ruling Communist Party's discipline, as Chinese President Xi Jinping pushes for great...

yahoo.com logo
Oct 25 • 10:12 PM EDT • Politics • yahoo.com
Nu Holdings (NU) Faces Political And Leadership Questions, Does It Look Fairly Valued?

Election shock and leadership change put Nu Holdings in focus Nu Holdings (NYSE:NU) is under fresh scrutiny after a Brazilian election result sparked a double digit overnight drop in the stock, just as the fintech disclosed a pending chief technology officer departure. Over the past month, Nu Holdings has seen an 11.55% share price return and a 4.12% gain over seven days, even though the year to date share price return is down 10.93% and the one year total shareholder return has declined...

finance.yahoo.com logo
Oct 25 • 10:07 PM EDT • Politics • finance.yahoo.com
World-First Cancer Vaccine Cuts Melanoma Recurrence or Death Risk by 42% in Landmark Trial

"This has not been achieved before in the history of cancer drug development."

sciencealert.com logo
Oct 25 • 10:00 PM EDT • Science • sciencealert.com
Illustration shows "Cyberattack" text and PHP code

The word "Cyberattack" and PHP code are displayed on a screen in this illustration taken on October 22, 2026.

lufkindailynews.com logo
Oct 25 • 9:48 PM EDT • Business • lufkindailynews.com
Il Volo celebrates nearly 20 years of musical harmony

Longer than many marriages and most rock bands, the Italian singing trio Il Volo have been together for almost 20 years. They’ve gone from teenagers to 30-somethings while selling more

floridaweekly.com logo
Oct 25 • 9:00 PM EDT • Entertainment • floridaweekly.com
Trump critic Lula wins reelection in Brazil, securing fourth presidential term

Brazil’s President Luiz Inácio Lula da Silva, a vocal critic of President Donald Trump, has been reelected in a result that provides relief to critics of widening U.S. influence in

journalgazette.net logo
Oct 25 • 8:58 PM EDT • Business • journalgazette.net
Vandalia Health recognized for digital health achievement

Vandalia Health earned Level 9 recognition in both acute and ambulatory care in the 2026 Digital Health Most Wired Survey.

mybuckhannon.com logo
Oct 25 • 8:53 PM EDT • Health • mybuckhannon.com
Cubs Trade Of Edward Cabrera An Early Lose-Lose Deal

A high-stakes gamble for Edward Cabrera backfired in Chicago as the right-hander's metrics plummeted, leaving the North Siders searching for answers amidst a looming rotation crisis.

sports.yahoo.com logo
Oct 25 • 8:39 PM EDT • Sports • sports.yahoo.com
Politics Unplugged (Full Episode) Oct. 25, 2026

On this week's episode of Politics Unplugged, host Dennis Welch and a panel break down Arizona's election landscape one week out: pessimistic voter mood, suppressed independent turnout, lagging GOP enthusiasm, and Democrats gaining ground. They discuss Elon Musk's late spending in competitive House races and debate the impact of big money flooding the state. The show also covers a widely condemned Ohio attack ad by Vivek Ramaswamy that weaponizes a rival's childhood abuse—drawing praise from Trump and Vance but bipartisan outrage.

azfamily.com logo
Oct 25 • 8:31 PM EDT • Politics • azfamily.com
FL GOP Rep. Carlos Gimenez: I don’t want my children or grandchildren to face a nuclear Iran
cnn.com logo
Oct 25 • 8:25 PM EDT • Politics • cnn.com
😐 Neutral (0%)
Simmons’ Behavior Shows Why Bieniemy Was Hired
sports.yahoo.com logo
Oct 25 • 8:25 PM EDT • Sports • sports.yahoo.com
Johnson County Focus on Youth Fund promotes access to children’s mental health resources

This is an installment of a series exploring youth mental health. The Daily Iowan has received a grant and is partnering with the Solutions Journalism Network to explore the topic. The Johnson County Focus on Youth Fund has been promoting access to children’s mental health resources by providing funding for families who can’t afford services....

dailyiowan.com logo
Oct 25 • 8:13 PM EDT • Health • dailyiowan.com
Attackers kill nurse, severely injure health worker responding to Ebola case in eastern Congo

The World Health Organization reports that a nurse has been killed and a health worker severely injured in an attack while responding to an Ebola alert in Congo. This attack,

oskaloosa.com logo
Oct 25 • 8:01 PM EDT • Health • oskaloosa.com
Deep dive
😐 Neutral (5%)
ahah
50%
sad
50%
Chinese scientists discover “D-rex,” a giant fungus with roots stretching back 65 million years

Scientists have discovered a giant new fungus in China that grows up to 20 inches tall and weighs nearly five pounds, making it the largest known of its kind. Dubbed “D-rex,” its evolutionary lineage appears to have emerged shortly after the dinosaurs went extinct, raising intriguing questions about how that ancient catastrophe may have shaped its evolution.

sciencedaily.com logo
Oct 25 • 8:00 PM EDT • Science • sciencedaily.com
Global Scientist Mobility: Redrawing the Innovation Map

Global scientist mobility patterns reveal how knowledge networks evolve. Learn why policy must shift from attracting talent to enabling circulation.

weforum.org logo
Oct 25 • 8:00 PM EDT • Science • weforum.org
Young Scientists Congress: New technologies take centerstage at science exhibition in Wenzhou

The World Young Scientists Congress has opened in Wenzhou, east China's Zhejiang Province. More than 800 scientists and entrepreneurs from over 60 countries and regions are attending the event which includes an exhibition of the latest technologies. We spoke with some of the visitors to the event.

news.cgtn.com logo
Oct 25 • 8:00 PM EDT • Science • news.cgtn.com
2026 KlarText Prize for Science Communication: Klaus Tschira Foundation Honors Seven Researchers

What exactly did you do in your doctoral dissertation? The Klaus Tschira Foundation honors the most compelling answers to this question with the KlarText Prize for Science Communication. On Octobe ...

chemeurope.com logo
Oct 25 • 8:00 PM EDT • Science • chemeurope.com
Betting odds released for Michigan vs Rutgers

Can Michigan cover the spread versus Rutgers?

sports.yahoo.com logo
Oct 25 • 7:56 PM EDT • Sports • sports.yahoo.com
$5,000 checks, political attacks and winding remarks: Takeaways from Trump’s Michigan rally
mlive.com logo
Oct 25 • 7:49 PM EDT • Politics • mlive.com
Trump invokes anti-Muslim rhetoric to attack El-Sayed at Port Huron rally

President Donald Trump has been telling crowds of supporters at rallies across the nation that they should vote in November as if he is on the ballot — a theme he invoked again in Michigan this weekend.

theoaklandpress.com logo
Oct 25 • 7:32 PM EDT • Entertainment • theoaklandpress.com
Chiefs vs. Seahawks live updates, inactives, where to watch: Kenneth Walker III faces Seattle for first time since Super Bowl MVP run
sports.yahoo.com logo
Oct 25 • 7:01 PM EDT • Sports • sports.yahoo.com
Donald Trump praises Nicki Minaj’s ‘beautiful ass’ during rally speech: ‘It’s hard to miss’

Donald Trump made a lewd comment at the lectern while speaking at a Michigan rally about the anatomy of one of his strongest supporters, Nicki Minaj.

ew.com logo
Oct 25 • 7:01 PM EDT • Entertainment • ew.com
Kids celebrate with big Halloween fun at University Health's Fall Fest!

Hundreds of children who were born prematurely or with special needs reunited Thursday night for University Health’s annual Halloween Fall Fest, turning a night that was only open to families into a celebration of

news4sanantonio.com logo
Oct 25 • 6:53 PM EDT • Health • news4sanantonio.com
Early voting underway in Michigan

Early voting began Saturday, Oct. 24 in Michigan. County officials say the first day of early voting went well and more than half of mail-in ballots have already been returned.

abc12.com logo
Oct 25 • 6:51 PM EDT • Politics • abc12.com
Families celebrate Halloween with a side of science at Nature Museum
yahoo.com logo
Oct 25 • 6:42 PM EDT • Science • yahoo.com
With flu season off to an unusually early start, here's what doctors are seeing

It's not even Halloween yet, but doctors say flu season off to an unusually early start.

nbcchicago.com logo
Oct 25 • 6:39 PM EDT • Health • nbcchicago.com
"I Didn't Seek Help": Terry Bradshaw Reveals Mental Health Struggle; Credits Wife for Pulling Him Through the Darkest Moments

For decades, 4x Super Bowl Champion Terry Bradshaw was hailed for his chirpy, fun-loving personality, but only a few knew the battle he hid under his jokes. Bradshaw struggled to understand that battle for a long period, dealing with darkness that kept returning even when his life was supposedly going well.

sports.yahoo.com logo
Oct 25 • 6:30 PM EDT • Health • sports.yahoo.com
ATM stolen from business in Brighton Park, Chicago police say

Chicago police are looking for the people who stole an ATM from a convenience store Sunday morning on the city's Southwest Side.

abc7chicago.com logo
Oct 25 • 6:20 PM EDT • Business • abc7chicago.com
😐 Neutral (7%)
Matthew Stafford breaks Rams franchise record for touchdown passes

LAS VEGAS (AP) — Matthew Stafford added another milestone to his NFL career on Sunday, throwing his 155th touchdown pass for the Los Angeles Rams to break the franchise record.Stafford surpassed Roman Gabriel, who threw 154 TD passes for the Rams from 1962-72.

sports.yahoo.com logo
Oct 25 • 6:11 PM EDT • Sports • sports.yahoo.com
A new state on the way? More Illinois counties could vote to leave Chicago behind

More than 30 counties have already approved the non-binding measure to leave Illinois

yahoo.com logo
Oct 25 • 6:06 PM EDT • Politics • yahoo.com
The Next FRIDAY THE 13TH Movie Can Finally Fix An Infamous Mistake

We don’t know precisely when, but a new Friday the 13th movie is coming. After a 17-year drought, the franchise has come back to life, most recently with the release of Crystal Lake on Peacock, a show...

yahoo.com logo
Oct 25 • 6:00 PM EDT • Entertainment • yahoo.com
WHO chief praises Korea's role in global health, vaccines and pandemic preparedness

Tedros Adhanom Ghebreyesus said that Korea's training hub and AI expertise can strengthen global health security and pandemic preparedness.

koreajoongangdaily.com logo
Oct 25 • 6:00 PM EDT • Health • koreajoongangdaily.com
Trump escalates rhetoric against El-Sayed as he tries to undermine Democrat in Michigan Senate race

The Republican president has been attacking El-Sayed's faith throughout the campaign and claiming his past statements and background show a sympathy for extremists.

pbs.org logo
Oct 25 • 5:50 PM EDT • Politics • pbs.org
Health West Chubbuck expands hours, adds X-ray services and two new providers

CHUBBUCK — Health West has announced that it has expanded the services offered at Health West Chubbuck and that it has added two new providers to its staff as well

idahostatejournal.com logo
Oct 25 • 5:11 PM EDT • Health • idahostatejournal.com
Volkswagen Bet On Xpeng To Save Its China Business, But Buyers Aren't Showing Up

Volkswagen once dominated China’s automotive market, but the rise of domestic electric vehicle manufacturers has turned its fortunes upside down. Hoping to regain lost ground, the German automaker partnered with Chinese EV specialist Xpeng in ... Read more

finance.yahoo.com logo
Oct 25 • 5:00 PM EDT • Business • finance.yahoo.com
Mobile County Health Department updates sentinel chicken test

It concerned testing for St. Louis encephalitis

fox10tv.com logo
Oct 25 • 4:30 PM EDT • Health • fox10tv.com
☹️ Negative (-11%)
ahah
57%
love
43%
Cleveland Browns rookie WR hits historic mark against Titans

KC Concepcion’s 129 receiving yards places him in the Top 10 for a single game by a rookie in franchise history.

sports.yahoo.com logo
Oct 25 • 4:22 PM EDT • Sports • sports.yahoo.com
😐 Neutral (0%)
Bears Offensive Blueprint on Full Display in Win Over Patriots
sports.yahoo.com logo
Oct 25 • 4:14 PM EDT • Sports • sports.yahoo.com
13 Short And Sweet Scary Games To Cram Before Halloween

If you're lagging behind on your annual intake of ghouls and goblins, enjoy this selection of brief creeps, from retro classics to odd indie frights

kotaku.com logo
Oct 25 • 4:09 PM EDT • Technology • kotaku.com
Michigan basketball gets reality check in exhibition loss vs Houston

Michigan writer Tony Garcia offers three observations from the Wolverines' 83-66 loss to Houston in its final exhibition.

sports.yahoo.com logo
Oct 25 • 3:42 PM EDT • Sports • sports.yahoo.com
Barcelona host Real Madrid in anticipated Clásico clash

2026-10-25T20:12:58ZThere have been a few crunching tackles on both sides in the last few minutes and now the benches have taken exception as there is a little coming together in the center of the par...

sports.yahoo.com logo
Oct 25 • 3:33 PM EDT • Sports • sports.yahoo.com
‘Masterplan’: Too lightweight to make an impact

Pretty faces can’t overcome ho-hum plotting

davisenterprise.com logo
Oct 25 • 3:08 PM EDT • Entertainment • davisenterprise.com
What To Make Of The Washington Nationals Catching Unit

Analyzing the 5 Nats catchers most likely to make a big league impact in 2027

sports.yahoo.com logo
Oct 25 • 3:00 PM EDT • Sports • sports.yahoo.com
MAPPED: The states Trump and top Democrats are targeting before Election Day

With Election Day less than two weeks away, Trump rallied in Florida, Georgia and Michigan as both parties deploy top surrogates to battlegrounds.

foxnews.com logo
Oct 25 • 2:15 PM EDT • Politics • foxnews.com
Jordan FA chief says AFC Congress ‘pure politics’ at behest of Infantino
aljazeera.com logo
Oct 25 • 2:05 PM EDT • Politics • aljazeera.com
Inside 26-year-old’s club for million-dollar Chattanooga business owners

At 2nd American Restaurant on Thursday night, around 85 entrepreneurs who have scaled their businesses to at least $1 million in annual revenue sat to a family-style meal of beef cheek roast, airline chicken and the restaurant's signature bowl of mashed potatoes.

timesfreepress.com logo
Oct 25 • 2:01 PM EDT • Business • timesfreepress.com
BCM hosting special Nov. 13 show for America 250

BRISTOL — In partnership with The Crooked Road: Virginia’s Heritage Music Trail, Mountain Empire Children’s Choral Academy, and Theatre Bristol, the Birthplace of Country Music Museum is bringing together an

therogersvillereview.com logo
Oct 25 • 1:30 PM EDT • Entertainment • therogersvillereview.com
😐 Neutral (0%)
Scientists Discover How Excess RNA Can Disrupt the Energy Supply Inside Cells

Scientists at Texas A&M University discovered that excess RNA can interfere with the machinery cells use to produce energy, even without triggering certain immune defenses. The findings reveal an unex...

yahoo.com logo
Oct 25 • 1:19 PM EDT • Science • yahoo.com
‘Clayface’ Ties ‘Obsession’ For A Rotten Tomatoes Audience Score Record

'Clayface' has a Rotten Tomatoes audience score that matches Obsession's a wild achievement for the comic book film.

yahoo.com logo
Oct 25 • 1:19 PM EDT • Entertainment • yahoo.com
Sunday Open Thread

There is no Jays news and I’ve got nothing to talk about, so lets have an open thread. We had the second great World Series game in a row last night. I like watching baseball (or any sport) when I have no rooting interest. After a season of caring about every Jays game, I like […]

sports.yahoo.com logo
Oct 25 • 1:17 PM EDT • Sports • sports.yahoo.com
☹️ Negative (-10%)
love
67%
wow
33%
China Star Entertainment (SEHK:326) Stock Looks Richly Priced As Its 8.6x Run Continues

China Star Entertainment has logged very strong multi year share gains, so the key issue now is whether the current price can be supported by the value of assets on its balance sheet. For anyone looking at the stock today, the immediate question is how that share price lines up against its book value. Over the past 3 years the stock has returned about 8.6x. This puts a lot of weight on whether the underlying equity in the business justifies this kind of move when you compare it with the...

finance.yahoo.com logo
Oct 25 • 1:06 PM EDT • Entertainment • finance.yahoo.com
Business People: Evereve names industry vet Sarah Clary to advise on creative

RETAIL Evereve, an Edina-based women’s fashion retailer, announced it has named Sarah Clary as advisory chief creative officer. Clary previously has led creative direction campaigns and brand strategy for Hill House Home, Veronica…

twincities.com logo
Oct 25 • 1:01 PM EDT • Business • twincities.com
3 Cubs Who Will Decline Their Options
sports.yahoo.com logo
Oct 25 • 1:01 PM EDT • Sports • sports.yahoo.com
'Not a one-person job:' Bernardsville explores exit from Bernards Health Department

BERNARDSVILLE - Concerns about costs have led borough officials to consider cutting off decades-long services from the Bernards Township Health Department and switching to the Somerset County Health Department.

newjerseyhills.com logo
Oct 25 • 12:27 PM EDT • Health • newjerseyhills.com
Kansas at Duke: Exhibition OGT

Kansas basketball hopes to follow the football team with a win today. Yeah, this game doesn’t count, but any time you’re playing Duke you want to win. Plus, this exhibition game is a big enough deal that ESPN is broadcasting it live (probably because they know everyone else will be watching football. I’m probably going […]

sports.yahoo.com logo
Oct 25 • 12:21 PM EDT • Sports • sports.yahoo.com
😐 Neutral (6%)
wow
100%
Kings' Veterans Praise Rookie Acuff After 33-Point Showing

The Sacramento Kings are yet to get a win, but Darius Acuff Jr. looks like the high-octane guard that the franchise so desperately needs. Coming off a 33-point outburst, how will Acuff play against the Memphis Grizzlies?

sports.yahoo.com logo
Oct 25 • 12:13 PM EDT • Sports • sports.yahoo.com
3 comments | Progressive Democrats are closely watching four Senate...

Progressive Democrats are closely watching four Senate races in the upcoming midterm elections. Our politics reporter Kellen Browning explains why.

facebook.com logo
Oct 25 • 12:07 PM EDT • Politics • facebook.com
😐 Neutral (0%)
Blue Ivy takes the stage, Destiny’s Child reunites at Jay-Z’s L.A. concert

Blue Ivy Carter joined dad Jay-Z onstage for a piano accompaniment, while mom Beyoncé cheered her on with two very special guests.

ew.com logo
Oct 25 • 11:59 AM EDT • Entertainment • ew.com
RJW Logistics to open second Northwest Arkansas office

Chicago-based RJW Logistics Group, which has a Bentonville office, plans to open an additional Northwest Arkansas office amid client growth and to support demand for a new logistics program offered...

talkbusiness.net logo
Oct 25 • 11:55 AM EDT • Business • talkbusiness.net
2 political experts question Chicago Mayor Brandon Johnson's tax proposals for 2027 budget
cbsnews.com logo
Oct 25 • 11:55 AM EDT • Politics • cbsnews.com
High-Signal Publisher
Chivu: “The boys gave everything right to the end”

Cristian Chivu wasn't the only one who couldn't bear to watch Zielinski's decisive penalty. The Inter coach bent over on the touchline, looking away as the midfielder stepped up to take it. When the b...

sports.yahoo.com logo
Oct 25 • 11:45 AM EDT • Sports • sports.yahoo.com
How Nathan Fielder's cringe-comedy career led him to Elizabeth Holmes

Spoiler alert! We're discussing the themes and structure of the Elizabeth Holmes documentary "You Can See Everything" and touching on a surprising aspect of its second half, so turn away if you want to go in completely cold.

thenewstribune.com logo
Oct 25 • 11:34 AM EDT • Entertainment • thenewstribune.com
ESMO: Roche touts ‘convincing’ phase 3 KRAS data after win over rivals

Roche has shed more light on its investigational KRAS G12C inhibitor's phase 3 victory over Amgen’s Lumakras and Bristol Myers Squibb’s Krazati. The open-label Krascendo 1 trial enrolled 338 people with previously treated KRAS G12C-mutated non-small cell lung cancer (NSCLC). Patients who had already received a KRAS G12C inhibitor or pan-KRAS/RAS inhibitor were excluded from the trial. Participants received either divarasib once daily, Lumakras once daily or Krazati twice daily. Roche announced back in July that divarasib had demonstrated statistically significant improvements in progression-free survival (PFS) and overall survival (OS), meeting the trial’s primary and key secondary endpoints. But the Swiss pharma had been holding back the detailed data until now. At the European Society for Medical Oncology (ESMO) Congress in Madrid, Roche revealed that median OS for the 167 patients who received divarasib was 17.7 months, compared to 12 months for the 171 patients who received Lumakras or Krazati. The benefit was similarly clear when it came to median PFS, which stood at 9.8 months versus 5.7 months, respectively. A total of 44% of patients receiving divarasib were alive without disease progression at one year, compared to 24% of the control group, according to Roche’s presentation. It was a similar story for the objective response rate, which came in at 58% for divarasib versus 32% for the control group, while median duration of response was 11.9 months versus 6.9 months. Stefan Frings, M.D., Ph.D., deputy chief medical officer at Roche Pharma, told Fierce that the data made for a “very comprehensive, strong package, which should be convincing to health authorities.” “It’s an important advance for patients with lung cancer,” Frings said in an interview at a Madrid hotel during the conference. “It's a second-line setting, and patients who receive divarasib benefit compared to the current first-generation KRAS G12C inhibitors by having far longer overall survival,” he continued. “They live longer. They have better progression-free survival, better response rates, and with a safety profile which is—if [anything]—even better,” he said. According to Roche, 4.8% of patients receiving divarasib discontinued treatment due to treatment-related adverse events, compared to 11.7% in the control group. Serious treatment-related adverse events were also less common with divarasib, at 7.8% versus 15.2%. Roche’s confidence in divarasib had been building even before this phase 3 success. The candidate had already shown better potency and selectivity than the incumbent KRAS G12C inhibitors Krazati and Lumakras in preclinical tests. After cross-trial comparisons suggested that the edge translated into better clinical outcomes, Roche axed a study comparing divarasib to the chemotherapy docetaxel and went toe-to-toe with Lumakras and Krazati. “We designed the drug on purpose with higher potency and better selectivity,” Frings explained. “So, based on preclinical models, we clearly knew it would be superior to the first generation.” “It’s honestly not so frequent that pharma companies go head-to-head,” he added. “But if you want to make a point, if you want to convince payers, prescribers and patients … then a head-to-head win is rather rewarding.” While Amgen and BMS reached the regulatory finish line first for KRAS G12C-mutated, locally advanced or metastatic NSCLC in 2021 and 2022, respectively, they have struggled to capitalize on their head start. Krazati brought in $55 million for BMS in the second quarter, while Lumakras delivered $111 million to Amgen. For its part, Roche is aiming for peak divarasib sales of 1 billion to 2 billion Swiss francs ($1.2 billion to $2.5 billion), according to Frings. The Big Pharma is currently recruiting patients into a phase 3 trial comparing divarasib plus Keytruda against Keytruda plus chemotherapy in previously untreated advanced or metastatic nonsquamous KRAS G12C-mutated NSCLC. Roche has previously suggested that sales in metastatic disease would account for most of the forecast. Frings was tight-lipped on the exact timeline for a regulatory filing but said the Swiss pharma is “certainly keen to get this to as many patients as possible around the world.” Roche has more RAS drugs coming up behind divarasib. The pharma has already launched phase 1 trials of a pan-RAS inhibitor called RG6505 and a KRAS G12D inhibitor dubbed RG6620 in solid tumors. Roche’s partner Chugai Pharmaceutical is also testing a pan-KRAS inhibitor called AUBE00. Roche has made a “deliberate effort” to test a range of RAS drugs, Frings said. “If you have many rare mutations and you are scrambling to find sufficient patients, a pan-RAS inhibitor makes a lot of sense,” he explained.

fiercebiotech.com logo
Oct 25 • 11:30 AM EDT • Health • fiercebiotech.com
Cam Skattebo Update: Will Giants Star RB Play Against Texans?

New York Giants share news on RB Cam Skattebo after benching in Week 6. The post Cam Skattebo Update: Will Giants Star RB Play Against Texans? appeared first on HEAVY.

sports.yahoo.com logo
Oct 25 • 11:18 AM EDT • Sports • sports.yahoo.com
Postpartum recovery window may play a critical role in maternal aging and long-term health

In many studies, it appears that women who have more children have a higher risk of heart disease and a shorter life span, but this effect is inconsistent across populations and no good explanation for ...

medicalxpress.com logo
Oct 25 • 11:00 AM EDT • Health • medicalxpress.com
GO Health asks families to be lead-aware

BATAVIA — Area health departments are encouraging families to get the facts and get their children and homes tested for National Lead Poisoning Prevention Week.

thedailynewsonline.com logo
Oct 25 • 11:00 AM EDT • Health • thedailynewsonline.com
Michigan Gov. Gretchen Whitmer says America is ready to elect a Woman

The Michigan governor did not deny that she was exploring a potential run for president in 2028.

nbcnews.com logo
Oct 25 • 10:56 AM EDT • Politics • nbcnews.com
High-Signal Publisher
Face the Facts: New health insurance helps early childhood educators

Child care is expensive, and keeping qualified workers on the job is part of the challenge. Now, Connecticut is offering a new health insurance subsidy to help early childhood educators lower their monthly premiums. Rep. Kate Farrar (D-West Hartford) explains how it works and why it could make a difference for families. Mike Hydeck: For years, Connecticut has had among…

nbcconnecticut.com logo
Oct 25 • 10:48 AM EDT • Health • nbcconnecticut.com
University of Rochester Medicine Home Healthcare holds inaugural Hospice 5K

13WHAM ABC Rochester provides local news, weather forecasts, traffic updates, health reports, notices of events and items of interest in the community, local sports and entertainment programming for Rochester and nearby towns and communities including Greece, Victor, Pittsford, Penfield, Henrietta, Webster, Irondequoit, Fairport, Chili, Gates, Rush, Wheatland, Canandaigua, Farmington, Spencerport and Hilton.

13wham.com logo
Oct 25 • 10:44 AM EDT • Health • 13wham.com
10 Thoughts From Watching Others Sweat It Out

Back during the very lean years of the Ray Goff era in Athens, a certain revered columnist for the Macon Telegraph joked in a weekly prediction column that Georgia would lose to “Open” during its upcoming bye week. Thankfully, those years have passed by, and the outlook for Georgia during open weeks for what is […]

sports.yahoo.com logo
Oct 25 • 10:28 AM EDT • Sports • sports.yahoo.com
😐 Neutral (-1%)
ahah
100%
Amid first 0-3 start since 2007, Giannis-led Heat searching for answers: ‘We’re not in panic mode’

The Heat’s Giannis Antetokounmpo era is off to a rough start.

miamiherald.com logo
Oct 25 • 10:16 AM EDT • Sports • miamiherald.com
Michigan's Jason Beck promised change, but numbers tell another story

Michigan football vowed to fix its perimeter run game or stop it, but the team continues to struggle on the edge.

sports.yahoo.com logo
Oct 25 • 10:04 AM EDT • Sports • sports.yahoo.com
Roots music fest fun in downtown Yadkinville

Click here to view this article from yadkinripple.com.

yadkinripple.com logo
Oct 25 • 10:04 AM EDT • Entertainment • yadkinripple.com
Adam Schiff responds to DOJ’s Alaska threat: ‘it’s Alaska’s business’ to run elections

In an exclusive interview with Meet the Press, Sen. Adam Schiff (D-Calif.) says “it's not the federal government's business to run Alaskan elections,” after the Justice Department sued to block certification of Alaska’s election results if Sen. Dan Sullivan loses, due to another candidate with the same name appearing on the ballot.

nbcnews.com logo
Oct 25 • 9:19 AM EDT • Business • nbcnews.com
High-Signal Publisher
😐 Neutral (0%)
Calvert liquor store gets license transfer; other business fined

New management will be taking over a liquor store in Dunkirk sometime in November.

somdnews.com logo
Oct 25 • 9:05 AM EDT • Business • somdnews.com
Clay Walker Christmas coming to NPAC Nov. 29

GREENEVILLE — Rumor has it … it’s shaping up to be A Clay Walker Family Christmas.

therogersvillereview.com logo
Oct 25 • 9:00 AM EDT • Entertainment • therogersvillereview.com
‘Dream big’: The Seattle-area kids and teens launching businesses

Some among the Seattle area's Generation Z and Alpha age groups are diving headfirst into entrepreneurship.

seattletimes.com logo
Oct 25 • 9:00 AM EDT • Business • seattletimes.com
Business lessons are coming to liberal arts schools

A new AP business with personal finance course continues the growth of teaching kids about how to make money and keep it.

npr.org logo
Oct 25 • 8:48 AM EDT • Business • npr.org
High-Signal Publisher
AP Business lessons are helping high school students learn how to manage money

A new AP business with personal finance course continues the growth of teaching kids about how to make money and keep it.

npr.org logo
Oct 25 • 8:48 AM EDT • Business • npr.org
High-Signal Publisher
Browns QB Shedeur Sanders Pegged for Deadline Exit

The Browns are approaching a quarterback decision that could reshape their roster before the trade deadline. The post Browns QB Shedeur Sanders Pegged for Deadline Exit appeared first on HEAVY.

sports.yahoo.com logo
Oct 25 • 8:39 AM EDT • Sports • sports.yahoo.com
Local breakfast chain plans Derby expansion

The Easy Egg, a Wichita-based breakfast and lunch restaurant, recently announced plans to expand into Derby. Reports indicate the local chain will take over the space at 317 N. Rock

derbyinformer.com logo
Oct 25 • 8:35 AM EDT • Business • derbyinformer.com
Trump campaigns in Michigan one day after Obama rallied against him

President Donald Trump will campaign for nominee Mike Rogers in Michigan, a day after former President Barack Obama criticized his administration in the state. Follow for live updates.

cnn.com logo
Oct 25 • 8:30 AM EDT • Politics • cnn.com
Trump's midterm swing brings him to Michigan as Republicans aim to undermine El-Sayed in Senate race

President Donald Trump's busy midterm campaign schedule is bringing him to Michigan, where Republicans hope to claim an open Senate seat on Election Day | Newsradio 1140 WRVA

audacy.com logo
Oct 25 • 8:28 AM EDT • Politics • audacy.com
Trump's midterm swing brings him to Michigan as Republicans aim to undermine El-Sayed in Senate race

President Donald Trump's busy midterm campaign schedule is bringing him to Michigan, where Republicans hope to claim an open Senate seat on Election Day.

news4jax.com logo
Oct 25 • 8:27 AM EDT • Politics • news4jax.com
Trump's midterm swing brings him to Michigan as Republicans aim to undermine El-Sayed in Senate race

President Donald Trump's busy midterm campaign schedule is bringing him to Michigan, where Republicans hope to claim an open Senate seat on Election Day.

wsls.com logo
Oct 25 • 8:27 AM EDT • Politics • wsls.com
🙂 Positive (38%)