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ON THE JOB: “What is the Best Business Advice You’ve Ever Received?
Interviews by Deborah Jeanne Sergeant Sound advice can contribute to your success. We recently asked area business leaders, what was their best advice they’d ever received. Here’s what they said: “The best advice I ever received was from my then –boss, Gerry Church, Fulton plant manager at Miller Brewing Co. He told me that whenever I wanted to discuss a business problem or issue with him, I should also be prepared to offer possible solutions. It’s the difference between being proactive or reactive. It’s also the difference between being a leader or follower. That has served me well in any business relationship I have had since then.” — Stephen Chirello, Owner, Steve Chirello Advertising, Fulton “Someone will always do it for less; they will also take the most effort to service or satisfy and leave you for the next lower price.” — John M. Henry, Owner, Speedway Press, Mitchell Printing, Phoenix Press, Oswego “I’m going to answer this question by turning it around and giving my own advice that is, ‘Always treat every customer as if they were your only customer!’ We are celebrating our 50th anniversary in business this year. We started our business on March 25, 1976. My advice works.”” — Nick Chervinsky, President, Brewerton Pharmacy, Brewerton “’You need to toot your own horn, my grandfather, Howard D. Dice, told me.” — Beth Ann Dice, Women’s active aging and cancer recovery coach, Mission Movement Wellness Studio & Breast Cancer Recovery Studio, Fulton “In the micro enterprise class, they taught, ‘Get a good lawyer, accountant and bank.’ That was over 30 years ago and I still have those three today. I chose good people I could grow with.” — Tony Pauldine, Owner, Anthony M. Pauldine General Contractors Inc., Oswego “From my grandfather; ‘Listen to everyone! You never know where you will get the solution you need.’” — Kevin Dean, Executive director, Oswego County Opportunities, Fulton “‘Preparation is the mother of success.’ My dad always drilled that into my head growing up, and it has helped me avoid a lot of snags in both my personal and professional life. Thanks, Dad!” — Bekkah Frisch, Owner and president, iHeart Holdings, Inc., Fulton “If you don’t take a risk and try, you will never know.” — Justin Taber, Owner, Torbitt’s Service Center, Oswego “Be ready to take a loss.” — Cody Seymour, Manager, Damiano’s Eatery, Mexico “I’ve received so much good business advice over the years. When people are giving you advice, always be curious rather than judgmental. Follow your gut. Doing the right thing is never the wrong thing.” — Dana Decker, Principal owner/broker, Berkshire Hathaway Home Services, Oswego ’Do it and figure it out later.’ It hasn’t failed me yet. Too many people take time to think about doing this and this and this and then the opportunity is over with. If it’s somewhat reasonable — if it’s not something outrageous — do it and figure it out later.” — Jeremy Allen, Licensed real estate salesperson, Acropolis Realty Group, Syracuse “’Try to meet the needs of the customer. Treat them like you’d like to be treated.’ It’s like the Golden Rule says.” — Douglas Dickson, Physician and associate at CNY Foot Surgery and Podiatry Care, East Syracuse “The best piece of business advice I’ve ever received applies to life in general: always be honest. Never overstate your capabilities and always be willing to ask questions. The more specific you can be in any given topic will always lead to a better outcome.” — Tom Fernandez, President, Woodbine Hospitality, Syracuse “As a business owner, the advice would be ‘Don’t overextend yourself. Especially in agriculture, expect issues to come up.’ If something is going right, it’s not true agriculture. This last season, we scaled very hard to field another crew. We got more drones, crew and generators based on projections. This last season hit the ag community hard with a very wet spring. We did 15,000 to 20,000 acres for fungicide and the same for cover crop seeding in 2024. We scaled to 25,000 to 30,000 for 2025. We ended up doing 2,000 for fungicide and 3,000 for cover crop seeding. That’s why that advice was good.” — Rick Jordan, Operations manager, CNY Drove Services, Clinton “’Keep your head down, mind your own business and do the best for your clients that you can do.’ It has a lot to do with my success in working for Galloway Century 21.” — Ed Fayette, New York state licensed real estate agent, Century 21 Galloway, Oswego “’Expand in all ways, always.’ It just keeps you going and keeps you growing.” — Stephen Baier, Licensed real estate person, The Real Estate Agency & Bouck Commercial, Auburn “The best advice is, ‘Your biggest asset you won’t see on the books because it comes from your employees.’” — David Flickinger, Owner, Edible Arrangements, Syracuse “Don’t take things personally when you’re working with the public.” — Leeann Desimone, Manager, Annie’s Hallmark Shop, Auburn “‘Follow up.’ The customer knows that you care about what you are doing and that their opinion counts. Sometimes they might be on the fence about whether they want to use your company. If they’re asking your opinion on things, they feel you are concerned about what you’re doing. They like to be kept in the loop if they’re spending money with you.” — Dorothy Casper, Saslesperson, SweetWoods Memorials, Phoenix “The best business advice I received is ‘Never be the smartest person in the room. Surround yourself with people who are smarter than you.’ That’s how you learn.” — Debbie Bilello, Owner, Virtual Office Solutions, Central Square “’You need to grow your business but you can’t grow too big too fast.’ That’s what we’ve done at Pinnacle Maintenance. We’ve tried to grow but not too fast. Along those same lines, there’s another good piece of advice, ‘Don’t take on more than you can handle because it only leads to a bad name for your business and a bad experience for your customers.’ It goes along the same lines as growing your business slowly and carefully.” — David Wines, Owner, Pinnacle Maintenance, Central Square “Always be on time and do what you say you are going to do.’ I’ve done very well following that advice. Most of my work is referral and I don’t really do any advertising so I have a pretty good customer base. It’s mostly word-of-mouth from satisfied customers.” — Robert J. Fleming, Owner, Bob Fleming Windows & Doors, Brewerton “’Concentrate on your finances, always pay your taxes, and form a team you can depend on. Try to help the community you’re in as much as you can.’ We do all of these all the time here. We give and give and give to the community and the community gives back to us always.” — Susan Bonnet, Co-owner, Bonnet Sales and Service, Central Square “Keep smiling. It brings a positive attitude to the workplace.” — Karin Lindsley, Vice president, DTS Truck Service, Syracuse “‘Customer service above all.’ Following this advice has served us very well.’ — Guy Fox, Owner, Fox’s Discount Parts, West Monroe “The best thing to do is to make sure you’re taking in more money than you’re spending. I wish I could say I’m a good businessman but I have been in business since 1981. I’m not a bean counter but work well with my hands and its’s served me well all these years and I am still in business.” — Matt McGill, Owner, Matt McGill Collision, Brewerton
Seniors: Carol Watson, 72
Owner of Carol Watson Greenhouse and Landscaping in LaFayette enjoys her growing business — still puts in six-, seven-day weeks By Mary Beth Roach Carol Watson, the owner of Carol Watson Greenhouse and Landscaping, has been in gardens since she could walk. Literally. She said she learned to walk in her grandfather’s garden, which was next door to her current home and business in LaFayette. Today, at 72, she is running the business that her mother, Claire, opened in 1981 as Watson Greenhouse. Watson worked part-time for her mom until 1990, when she joined her full time. While she may not have had any formal horticultural experience, she said she learned so much about growing and raising plants from her mom, who had an abundance of energy and talent. Now, after 35 years in the business full time, Watson has no plans to retire, although she joked that she’d like a couple of days off a week. On her seven-acre site, complete with four greenhouses, Watson said her favorite parts of the job are working with and educating her customers; helping some of her young customers build terrariums; conducting occasional class field trips; and supporting local art by decorating the shop with an eclectic mix of pottery from at least four area craftspeople. A one-time employee of the former Dey Bros. department store in Syracuse, Watson said she loves merchandising and enjoys displaying unique pieces of art on shelves and even suspending from ceilings. “We’re creative. We also had top quality plants. We got a reputation of quality plants and unusual products,” she said. It’s tending to her customers and her plants, showcasing the unusual products, and hosting special events to benefit the community that keep her motivated to work six to seven days a week. “I just love it. I love taking care of the plants. I’m one of the few people that really enjoys watering,” she said. And while she has cultivated a solid customer base over the years, she remains savvy in her marketing efforts to draw in new customers. For example, she does a gardening segment on CNY Central television; her active Facebook page has thousands of followers; and she hosts a number of unique events and classes that not only introduce her shop to potential new clients, but some benefit nonprofits as well. About 13 years ago, when the local symphony orchestra was struggling, she said she wanted to help. So, partnering with the group, she began offering concerts, called Soirees, featuring the Syracuse Orchestra’s string quartet. Following up on a suggestion from a customer whose brother is a deejay in retirement, specializing in sock hops, she hosted the greenhouse’s first sock hop. Plants got moved back toward the walls to make room for dancing; a caterer was brought in, offering diner-like food; guests came in period outfits; and proceeds went to the Food Bank of CNY. She is excited about doing it again in October. Via her website, she promotes the greenhouse as an “oasis in the snow,” offering visitors the opportunity to pick up some decorating and gift ideas while taking in the floral and citrus scents. And she also caters to her four-legged friends. Over this past winter, she said, she came up with a “brilliant idea,” although at the time she didn’t appreciate just how brilliant it would become. Feeling it too cold outside to take her dog for a walk, she opted to bring it into the greenhouse. And before long, she was inviting people to bring their dogs into the big greenhouse as well. She looks forward to extending that invitation again this upcoming winter season. For Watson and her customers, the greenhouse is always in season.
Newly discovered fossil challenges idea of ape origins in east Africa
The remains, discovered in 2023 and 2024, are incomplete, and made up of only a few jawbone fragments and worn teeth.
How mental health court works and who qualifies
After an 8-hour standoff, a 28-year-old man faces charges as his mother seeks civil commitment and his missed mental health court appearance comes to light.
City to consider seeking declaratory judgement on entertainment district TIF election
The Norman City Council will meet Tuesday to consider authorizing the city attorney’s office to initiate litigation to obtain a declaratory judgment on whether it has the legal authority to
Your Laboratory Does Not Have a Science Problem. It Has a Systems Problem
Most laboratory challenges trace back to fragmented workflows, weak infrastructure, and systems that were never designed for real-world operations
CPUID site hijacked to serve malware instead of HWMonitor downloads
: Six-hour breach turned trusted links into a coin toss between legit tools and credential stealers
Science with Stevie: Spring Allergies
Meteorologist Stevie Daniels gives us some tips on how to manage the pesky seasonal spring allergies in this Science with Stevie segment!
Russia trying to get into anti-drone rifle game with new AK bullets
Kalashnikov Concern said it plans to mass-produce the 30-round cartridges, which are meant to be fired by its AK-12 and split into fragments.
GHD’s Adrienne Young named to North Bay Business Journal’s Forty Under 40 of 2026
“You have to learn to trust your own judgment and speak up around other technical experts. And it can be intimidating when you might be the youngest person on that project team.”
Public comment open on wording of Maine transgender sports referendum question
The question will appear on the November ballot unless the bill is enacted by the Legislature as written.
LA business groups unite behind Bass and switch up their playbook
For the first time, the city’s fragmented business interests are coordinating their political efforts.
YouTube’s copyright system strikes again.
Nvidia’s own DLSS 5 trailer was taken down from YouTube after an Italian TV channel — which reportedly used the footage in a segment about the upscaling tech — issued copyright takedown requests for videos using the same clips. The takedown requests impacted some creators using the footage as well. [Image: https://platform.theverge.com/wp-content/uploads/sites/2/2026/04/nvidia-copyright-takedown.png?quality=90&strip=all]
14th Gen Core "Raptor Lake" Will Continue to be "Abundantly Available," Says Intel
Intel will continue to ensure production of its 14th Gen Core "Raptor Lake Refresh" desktop processors, 700-series motherboard chipset, and ensure continued availability of the Socket LGA1700 platform. In an interview with Club386, Intel's VP and GM of client segment technical marketing, Robert Hall...
OH WOW! Science Center will host interactive, augmented sandbox exhibit
OH WOW! The Roger & Gloria Jones Children’s Center for Science & Technology will host an interactive, augmented exhibit beginning Monday, April 6, 2026.
Nearly launched LG Rollable smartphone reveals its innovative internals in teardown video
Even Samsung’s 2026 foldables pale in comparison. If LG had not decided to exit the smartphone business, we could have seen a first rollable smartphone as early as 2021, one that was already more innovative five years ago than anything the foldable phone segment has produced recently, as a teardown shows.
Sphere Entertainment (SPHR) Is Up 17.4% After Wizard of Oz-Driven Revenue Surge and Global Expansion Plans
Sphere Entertainment recently reported past-quarter revenue growth of 28%, powered by the success of its “Wizard of Oz at Sphere” production in Las Vegas, which has sold more than two million tickets and helped narrow operating losses in the Sphere segment. On the back of this stronger performance, the company is now moving ahead with international Sphere developments in Abu Dhabi and National Harbor, signaling a push to replicate its immersive venue model beyond the US. We’ll now examine...
How The PENN Entertainment (PENN) Turnaround Story Is Shifting With New Targets And ESPN Progress
PENN Entertainment's fair value estimate has shifted from US$18.44 to US$19.11 per share, putting it closer to a cluster of recent Street targets in the mid to high teens and low US$20s. This revision aligns with analyst commentary that combines optimism around the interactive segment and free cash flow with lingering doubts about management credibility and the turnaround story. Read on to see how to track these changing targets and keep up with the evolving narrative around PENN. Analyst...
Trapped by his own image: Trump’s Iran War and the politics of ego
The judgment on the Trump administration’s war on Iran is already largely settled across mainstream media, public opinion, and much of the analytical sphere.
Google battles Chinese open-weights models with Gemma 4
: Now with a more permissive license, multi-modality, and support for more than 140 languages
Microsoft shivs OpenAI with three new AI models for speech and images
: About that partnership...
Research points to brain-based clues for mental health
In a split second, the brain determines whether an ambiguous situation is good or bad—and those snap judgments can reveal important information about a person. A new article by Husker psychologist Maital ...
Even Microsoft knows Copilot shouldn't be trusted with anything important
: Terms admit it is for entertainment only and may get things wrong
Publicis sharpens sports marketing focus with 160over90 acquisition
Publicis CEO Arthur Sadoun described sports as the firm’s “next big bet” as it tries to bring cohesion to an increasingly valuable but fragmented market.
Central banks' inflation mood puzzle: more judgment than science
The world's central bankers may be attempting the impossible: to get into the psyche of business executives, labour unions and ordinary households in real time to understand how they are navigating their finances through yet another energy shock.
A Look At Live Nation Entertainment (LYV) Valuation As Concerts Hit Records And Global Expansion Accelerates
Why Live Nation’s 2025 milestones have investors’ attention Live Nation Entertainment (LYV) is back in focus after reporting record adjusted operating income in its Concerts segment for 2025, hosting 159 million fans and outlining new venue openings across Latin America, Europe, and the U.S. See our latest analysis for Live Nation Entertainment. Live Nation’s latest results arrive after a 7.11% 90 day share price return and a 13.35% 1 year total shareholder return, which build on a very large...
Neta’s research points to brain-based clues for mental health
In a split second, the brain determines whether an ambiguous situation is good or bad — and those snap judgments can reveal important information about a person. A new article by Husker psychologist Maital Neta suggests that these responses, known as valence bias, could help identify risk factors for depression, anxiety and other stress-related conditions.
We know what day it is but these Raspberry Pi price hikes are no joke
: Who is going to drop nearly $400 on an underpowered Linux computer?
Trump’s Iran War and the Politics of Ego
The judgment on the Trump administration’s war on Iran is already largely settled across mainstream media, public opinion, and much of the analytical
Maine business leaders speak out against data privacy bill
Business leaders gathered in Portland Tuesday to speak out against a data privacy bill in Augusta.
Microsoft reaches for yet another out-of-band patch to deal with latest update issue
: Weren't these supposed to be 'atypical'?
Predicting spring bloom is an art
Do you ever wish you could predict the future? The National Park Service in Washington D.C. does it every year when they forecast when the Capitol’s cherry blossoms will reach peak bloom. People travel from all over the world to enjoy the annual National Cherry Blossom Festival and to glimpse these fragile flowers before they are gone. On this month’s Nature Quest, we learn the ins and outs of cherry tree blossoms, how scientists make that big prediction every year — and why all this focus on blooms can help scientists better understand climate change. This episode is part of Nature Quest, our monthly segment from listeners noticing a change in the world around them. To participate, send a voice memo to shortwave@npr.org with your name, location and your question about a change you're seeing in nature!Want to learn more about nature’s calendar? Check out our first Nature Quest episode on whether flowers are blooming early.Listen to every episode of Short Wave sponsor-free and support our work at NPR by signing up for Short Wave+ at plus.npr.org/shortwave.
GitHub backs down, kills Copilot pull-request ads after backlash
: Letting Copilot alter others' PRs was the wrong judgment call, says product manager
Lawsuit claims Maine transgender sports referendum signatures are not valid
The lawsuit was filed by Jane Gilbert, Mark Sayre and Kaitlin Webber in Cumberland County Superior Court on Friday.
A Nurse Educator on Resilience, Patient Care and the Future of Health - Newsroom | University of St. Thomas
Faculty member Dr. Vane Gichana brings a blend of clinical judgment and critical thinking when she instructs nursing students at St. Thomas.
Is an IDA Health Window the Global Health Financing Solution?
The global health architecture is facing intense scrutiny. There are now an A-Z of initiatives launched to lead the reform, from the Accra Reset to the Lusaka Agenda Secretariat and a WHO-led process. Critics have argued that the current system fails to focus on the poorest countries, fragments national systems, undermines country ownership, and displaces domestic health spending.
AKC Canine Health Foundation Joins All Access hosted by Andy Garcia to Explore the Science of Veterinary Innovation
The AKC Canine Health Foundation (CHF) is excited to announce a collaboration with the educational program "All Access hosted by Andy Garcia" to develop a documentary segment centered on canine health research. Set to film on April 15, 2026, at the Foundation's headquarters and the North Carolina State University College of Veterinary Medicine, the production will provide an objective look at how independent research improves the well-being of dogs, through highlighting CHF's pivotal role as a f
Will a Fragmented Electorate Undermine Black Political Strength?
Crowded primaries could signal a weakening of African American political power, but a more open and competitive political environment could also be a sign of democratic health.
Business owners say late notice of protest caused confusion along Montgomery
ALBUQUERQUE, N.M. (KRQE) – As protesters marched through northeast Albuquerque on Saturday, several nearby businesses say they felt left in the dark about when — or if — roads would be shut down. M…
Tyler Sloat Joins Hinge Health Board As Growth And Discipline Focus
Hinge Health (NYSE:HNGE) appointed Tyler Sloat to its board of directors, adding a leader with experience in high growth technology companies. Sloat has held senior roles at companies that have gone through rapid expansion and IPOs. The appointment signals a focus on scaling Hinge Health's business and strengthening governance as the company matures. Hinge Health focuses on digital musculoskeletal care, a segment that sits at the intersection of healthcare and technology. As employers and...
Scientists mimicking the Big Bang accidentally turn lead into gold
The physicists made an unexpected breakthrough
Aaron Judge dents an ambulance with second HR of season
The geography of science
Scientific activity has historically been concentrated in a small number of advanced economies, but the global landscape of research is undergoing rapid transformation. Using data on 44 million publications from 1980 to 2022, this column examines how the geography of science has evolved along three dimensions: where research is produced, what topics it studies, and where it is consumed through citations. It documents a substantial shift in scientific production from traditional Western leaders s emerging economies. Yet scientific attention and knowledge diffusion remain uneven, revealing a tension between the global expansion of scientific capacity and the continued fragmentation of the knowledge system.
Business groups warn Maine data privacy proposal could raise marketing costs, hurt growth
The Maine State Chamber of Commerce is urging CEOs and senior executives across the state to join its opposition.
Maine Science Teacher Prepares for NASA’s Summer Mission
BRUNSWICK (WGME) -- Karin Paquin, a science teacher at St. John’s Catholic School in Brunswick, is about to prove that her teaching skills are truly out of this
Portland kayak business searching for alternative locations after devastating wharf fire
Portland's Custom House Wharf is still months away from being rebuilt after this winter's devastating fire.
Anthropic tweaks timed usage limits to discourage Claude demand during peak hours
: AI biz makes some Claude conversations more costly to manage capacity
AMD’s new desktop CPU oozes cache out of all 16 cores
: Turns out massive caches are good for more than games. House of Zen boasts 5-13% perf boost over prior-gen part
GitHub hits CTRL-Z, decides it will train its AI with user data after all
: As of April 24 you'll be feeding the Octocat unless you opt out
Portland Planning Board rejects proposed buffer between entertainment venues
A proposed buffer that would determine the distance between large music venues is sparking controversy in Portland Wednesday night.
‘Girlypop Politics’ takes civics education to the airwaves
The host of the Salem-area radio segment aims to demystify how local government works, and encourages listeners to get involved
Augmenting citizen science with computer vision for fish monitoring
Monitoring river herring migration is essential for conservation and fisheries management. Researchers have now demonstrated a method using video and computer vision to supplement traditional methods and volunteer-based programs.
Madeline Shepley on the Wonders of Faith and Science
Madeline Shepley discusses sharing the wonder of the universe with kids, her role as a Catholic scientist, and her love of science fiction.
Verdict on chatbots in mental health screenings? Too judgmental
Chatbots used in mental health screenings aim to reduce the stigma associated with seeking help and to expand access to needed services. Because they cannot cast personal judgment, chatbots are considered ...
Neal Stephenson, who coined the term ‘metaverse’, says head-mounted VR hardware will never happen
: ‘People don’t like wearing things on their faces and don’t trust those who do’
Segment: Financing Action on Extreme Heat and Maternal and Newborn Health: The Way Forward
The segment “Financing Action on Extreme Heat and Maternal and Newborn Health: The Way Forward” will examine how innovative and better-aligned financing approaches can respond to these growing risks. Discussions will highlight country experiences in mobilizing domestic resources, opportunities to unlock and scale climate finance, and the role of heat-smart innovations in building resilient health systems. Particular attention will be given to low- and middle-income countries, where exposure and vulnerability remain highest, and where integrated solutions can deliver the greatest impact.
Small swings, high drama: why UK polls are less volatile than they seem
In what is beginning to look like a fragmented five-party system, small swings carry outsized political consequences
Microsoft: Removing some Copilots will improve Windows 11
: 'Doze boss admits OS needs smaller memory footprint, fixes for old issues like bad Bluetooth, more prominent WSL
Your Thymus and Your Healthspan
Our thymus gland plays a central role in the development or our immune system, specifically for supporting T cell development (how these cells got their name, maturation and differentiation in the thymus) and discriminating between self and foreign, non-self antigen proteins with production of dendritic cells. As we age, our thymus gland shrinks—the process known as involution—with progressive change from spongy to fatty tissue, with loss of functionality. But this process, with respect to timeline and extent, markedly varies from one person to the next. And to make things even more complicated, our thymus gland anatomy and precise location in the chest also is highly variable. So the famous Frank Netter diagrams from the 1960s (such as at left below) don’t capture the remarkable heterogeneity that a random set of 12 chest CT scans (below at right). What I consider as 2 landmark papers in Nature this week (here and here) used AI to quantify health of the thymus in 2 large cohorts, and then correlate the metric to a broad array of health outcomes. In this edition of Ground Truths, I’m going to cover three questions: (1) How was thymus health determined by AI?; (2) How is thymus health linked to key clinical outcomes? and (3) Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? Subscribe 1. How was thymus health determined by AI? This was accomplished by extensive work developing and validating an AI pipeline for 2 stages, the first for localization and segmentation of the thymus bed, and the second to quantify a digital marker, termed the thymic health score. There’s a lot to this algorithmic development, so I won’t go into all the details, but just provide a rudimentary outline of what was done. The 1st stage used supervised learning with 2 radiologists reviewing 2,461 chest CT scans. That work trained a 3D U-Net model to automatically identify the thymic bed’s 3D cropped region using center of mass coordinates, which reached 99.8% accuracy. The 2nd stage used a foundation model that was pre-trained with SwAV (which stands for Swapping Assignment between multiple Views), a self-supervised model, that generated a high-dimensional thymus representation of 4,096 features. That compares to the radiology reductionist and subjective scoring of 0 to 3 where 0 means the thymus is fully degenerated and fatty, and 3 is considered dense, intact glandular soft tissue. Notably, the self-supervised learning (SSL) performance was superior to supervised (AUC ~0.75 vs 0.55, respectively) reflecting the shallowness of the 0-3 classifier vs SSL’s holistic, self-taught AI. The thymic health score ranged from 0 to 100, with the highest number indexed to fully preserved thymic health. The algorithmic work extended to explainability with both Shapely value distribution, meaning the model was holistic not relying on any “magic” pixel, and occlusion sensitivity, demonstrating the model’s performance was not affected by ribs, sternum, lung tissue, but rather focused on the thymic bed directly. Below are a few saliency maps from the occlusion sensitivity that indicate the thymic bed focus, not affected by neighboring structures, using the jet color scale. Now the AI was ready for processing ~25,000 CT scans, each over 30 MB files, from the 2 large participant cohorts to provide a thymic health score, it did so in less than 14 hours, which is less than 2 seconds per scan! Share 2. How is thymus health linked to key clinical outcomes? The two cohorts were the National Lung Screening Trial, NLST (N=25,031) and the Framingham Heart Study, FHS (N=2,581) each with baseline demographics and long term follow up of >12 years for health outcomes. From the NSLT, you can see below that increased age and body-mass index were correlated to reduced thymic health. And, overall, men had reduced thymic health scores compared with women. There are a lot of graphs in the paper for outcomes, for both the NLST and FHS cohorts. To simplify the major outcomes, below is a composite Figure with striking reduction of all-cause mortality and for the different causes of death. The results were consistent between the 2 cohorts. For example, the cardiovascular mortality hazard ratio average was 0.57 in NLST and 0.38 in FHS (weighted to be 0.53 for the aggregate). The reduction of mortality also extended to digestive diseases and pulmonary disease (data not shown below). Lung cancer incidence was reduced by 36% for high vs low thymic health (Figure below, with a panel -incidence and b panel-mortality, adjusted for age, sex, BMI, smoking status). Notably, there was a smoker’s paradox: lower incidence and improved survival for lung cancer in smokers who had a high thymus health score. Smoking was associated with lower thymic scores whereas alcohol was not. Higher thymic health was linked to higher HDL cholesterol, lower triglycerides, lower fasting blood glucose, and lower systolic and diastolic blood pressure. Inflammation biomarkers, such as C-reactive protein and interleukin-6, were elevated in the people with lower thymic health scores. In their second paper, the same team looked at the relationship between thymic score and outcomes for 3,476 patients receiving cancer immunotherapy. The non-small cell lung cancer progression-free survival was reduced in patients with low thymic health score. A parallel relationship for survival was seen for other types of cancer including melanoma, breast, and kidney with a 44% lower risk among high thymic scores (Figure). A similar pattern was seen with different immune checkpoint inhibitors. The thymus health score outperformed programmed death ligand-1 (PD-L1)and tumor mutation burden (TMB) assay of the tumor and was an independent prognostic marker of progression-free survival. In this dataset, a direct connect with thymus score and adaptive immune function was noted with a correlation before cancer treatment for both T-cell diversity and thymus T-cell production (a metric known as T cell receptor excision circles). Thymus Removal Study There is a highly relevant citation about thymus function before moving onto ways to rejuvenate it. In 2023, a very important study of thymus removal during cardiothoracic surgery was published, with 1146 patients undergoing thymus removal vs 1146 matched controls (mean age 55 years). The adverse outcomes for thymus removal were striking, with a 2.9 higher risk of all-cause mortality and doubling of cancer incidence, 1.5 fold increase in cancer mortality, and 1.5-fold increase in autoimmune diseases. The immune function showed marked compromise after thymus removal, as reflected by CD4+ and CD8+ T cells (Figure below) Share Ground Truths 3. Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? In recent months we’ve learned a lot about the process of thymus involution and the pathways by which this may be modulated. Thymus involution is primarily due to loss to thymus epithelial cells (TECs) and there are 2 subtypes with different functions: the cortical, responsible for positive selection of T cells, and the medullary, for negative selection. When adipose tissue infiltrates the thymus, thymic adipocytes are pro-inflammatory, knocking out T-cell output. Likewise, systemic inflammation, or “inflammaging,” from smoking, obesity, and chronic stress promote thymic adipocytes. Now, from preclinical studies, we know about key pathways that account for these processes. Historically, back in 2014, FOXN1 was recognized as a single master transcription factor essential for TEC function, with studies in mice with forced FOXN1 upregulation leading to thymus regeneration. That laid the foundation for potential regrowth of quiescent thymus cells. It took awhile to find pathways to accomplish this goal and to even refute its role as the master regulator. The Liver-Thymus Axis Feng Zhang and his team recently showed that injection of an mRNA vaccine to the liver encoding DLL1, IL-7 and FLT3-L in combination, factors known to support thymopoiesis (Figure), successfully enhanced immune function in aged mice. However, the effect was transient. The FGF21 Story Two reports in 2025 addressed the thymus gland’s production of FGF21, a growth factor (fibroblast growth factor 21) and its control of thymus involution. This growth factor is also produced by the liver, but it doesn’t have impact on the thymus in aged rodent models. In contrast, The liver’s hepatocyte growth factor (HGF) has been shown to reverse senescent TEC structural changes. Growth hormone stimulates production of insulin growth factor-1 (IGF-1) in the liver and the thymus. Two small studies in human participants (TRIIM, for Thymus Regeneration, Immunorestoration, and Insulin Mitigation) of 6 and 50 people, respectively, treated with combined human growth hormone, metformin and DHEA, suggested the potential of slowing epigenetic aging and improving thymus mass and function. But the combination of drugs, small sample, and lack of controls make conclusions murky. Increased thymus FGF21 led to increased CD8 T cells in old mice and extended healthspan and improved physical performance. Building on the previous FOXN1 data, ablation of β-klotho, the obligatory co-receptor for FOXN1, accelerated thymic aging. The benefit to FGF21 was confirmed in a companion paper using an FGF21 knock-in mouse model showing thymus enlargement and increased TECs throughout the lifespan. (schematic Figure below). The accompanying editorial for these 2 papers speculated: “The proposed link between age-associated thymus involution and organismal aging is intriguing, and suggests we might seek to achieve systemic rejuvenation by counteracting thymic involution.” Other Factors Lessons from the Axolotl (Mexican Salamander) In an elegant set of experiments of the axolotl (Figure), known for its complete thymus regeneration after total surgical removal, mediators were identified. Surprisingly FOXN1 was dispensable. But midkine, a growth factor, appeared to be the driver, the initiator of thymus cell growth, survival, and repair. Other components that contributed were Postn+ (periostin-expressing mesenchymal niches) and Ccl19, a chemokine protein from the bloodstream. RANK and RANKL RANK (receptor activator of nuclear factor κB its ligand (RANKL) have been considered key regulators of medullary TECs. In a study of both aged mice and human thymus cell cultures, their key role was confirmed, with multiple benefits of resorting TEC function, recruitment of progenitor cells, and T cell development. Subscribe Summing Up This body of work strongly supports the health of the thymus gland as a critical regulator of human healthspan, not just a correlate or link. The new landmark studies are reinforced by the regenerative biology experimental models that have shown, via an array of mediators, that healthspan of aged mice is at least in part dependent on thymus gland function and its critical role for maintaining adaptive immunity. It sure seems that we’d be better off having an immune reservoir of naive T cells instead of a profile in older adults of exhausted, low quality, memory T cells, with a senescent phenotype. It is striking that we ignored the importance of the thymus gland for many decades. A wake-up call was the results of the thymectomy matched control study reviewed here, with the opposite of high thymic health score improved health outcomes. The convergence of AI and healthspan here is notable. The exceptional and laborious work for developing and validating (no less explaining) the AI to quantify thymus health set the foundation for probing the connect the major health outcomes in two cohorts with extensive follow-up. We’ve never had a way to meaningfully quantify the thymus gland before, so this represents important leverage of supervised, self-supervised, and transformer models. The study wouldn’t have been possible without AI. And it begs the question as to whether there are ways we can maintain our thymus at a high health score. But it’s not so simple to rejuvenate our thymus. There are multiple risks including the induction of autoimmunity, increasing the risk of cancer, and inducing a pro-inflammatory state. For example, factors that increase TEC proliferation could compromise the medulllary negative selection process and leak out auto-reactive (self-attacking) T cells. Thymic cells could be induced to proliferate, but we know, for example, that growth hormone and IGF-1 are associated with an increase risk of cancer. If thymus rejuvenation doesn’t clear out the accumulated senescent cells in older adults, then inflammation within the gland could block the production of TECs. Keeping these risks in mind, we now have identified many ways to keep our thymus healthy as we age that undoubtedly will be tested in clinical trials going forward. Ultimately, the benefit-to-risk tradeoffs will be defined. In the meantime, we have desperately needed an immunome. As I’ve stressed in multiple prior Ground Truths, we have no test in the clinic to assess a patient’s immune status! It was very encouraging for me to get an email from Hugo Aerts, the senior author of the landmark papers in the days after they were published: “I also wanted to say that your Substack on “Why We Need an Immunome” was inspiring for this work. We found it a very compelling perspective and greatly enjoyed reading it.” Just having an assessment of a person’s immune status via a chest CT scan, with millions of these performed per year, might help in guiding the right immunotherapy for cancer (e.g. more intensive, combinations for those with low thymic health scores) and help define people who are increased risk for age-related diseases of cancer, cardiovascular, and neurodegenerative. The main theme of Super Agers is that we now have many layers of data (genetics, proteins, biomarkers, organ clocks that can be integrated via multimodal AI) for us to define a person’s specific risk decades before one of these age-related diseases leads to symptoms, enabling prevention. From the new studies this week, we can add thymus health score as yet another way to understand a person’s risk, a window into their adaptive immune system and healthspan. And perhaps someday we will be able to safely rejuvenate the thymus, or maintain its health through one’s life, and use the thymus health score to monitor. NB: I wrote this post (No A.I.) A Quick Poll Loading... ********************************************************************* Thanks to Ground Truths subscribers (now > 200,000) from every US state and 212 countries. Your subscription to these free essays and podcasts makes my work in putting them together worthwhile. Please join! If you found this interesting PLEASE share it! Share Ground Truths Paid subscriptions are voluntary and all proceeds from them go to support Scripps Research. They do allow for posting comments and questions, which I do my best to respond to. Please don’t hesitate to post comments and give me feedback. Let me know topics that you would like to see covered. Leave a comment Many thanks to those who have contributed—they have greatly helped fund our summer internship programs for the past two years. It enabled us to accept and support 47 summer interns in 2025! We aim to accept even more of the several thousand who will apply for summer 2026.
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New dispute emerges around Subnautica 2’s early access release
Lawyers for the ousted—and now partially reinstated—leadership team of Unknown Worlds, the studio behind Subnautica 2, are crying foul over news that the game will be released into early access in May. The release announcement earlier this week was made improperly, potentially “damaging the game and sowing additional confusion among the Subnautica community,” the lawyers said in a letter sent on Tuesday to Vice Chancellor Lori Will of Delaware’s Court of Chancery. In their letter, the lawyers also floated the idea of asking Will to find Krafton in contempt of the court’s ruling. The letter was sent just one day after Will’s bombshell ruling that publisher Krafton had breached its contract with Unknown Worlds’ executive team, when it fired them last June. The new issue isn’t necessarily the May early access timeframe, but how the news was announced. The letter and Krafton’s response have not been previously reported. A quick recap of prior events: Subnautica 2 is an unreleased, underwater survival adventure and the most-wishlisted game on Steam. Last year, longtime Unknown Worlds CEO Ted Gill, along with studio co-founders Charlie Cleveland and Max McGuire, were fired by Krafton. They swiftly sued, saying the publisher had terminated them to avoid paying out up to $250 million in potential performance-based bonuses. The studio leaders had hoped to earn that with an early access release of the game, which Krafton had blocked. The publisher argued in court that Subnautica 2 wasn’t ready, which the ousted execs disputed. On Monday, Will ruled that Krafton had violated its contract, firing the execs to avoid the performance payouts, and that it had to reinstate Gill and give him full authority over any early access release for Subnautica 2. On Tuesday, IGN reported on a new memo issued that day to Unknown Worlds staff by Steve Papoutsis, the executive Krafton had put in charge of Unknown Worlds after the 2025 firings. In the note, Papoutsis said that Subnautica 2 had passed a key development milestone “last week” and that he and Krafton had determined the game “is ready for Early Access release in May.” This news appeared to catch the lawyers for Gill, Cleveland and McGuire by surprise. On Tuesday night, they sent a letter to Will expressing “serious concerns” about whether it would be possible to forge an agreement with Krafton consistent with the judge’s order. Papoutsis’ memo was a problem, they wrote. He didn’t have the authority to declare anything about Subnautica 2’s release. As of 9am ET on Monday, March 16, the effective date of Will’s order, Papoutsis wasn’t CEO of Unknown Worlds. Gill was. And, per Will’s order, only Gill could make Subnautica 2 release decisions. They continued: Krafton self-servingly announced the launch without any regard to its impact on the game, the team, or the community—let alone this Court’s Opinion. Announcing the release of a game is momentous, and it is typically accompanied by significant marketing activity, fanfare, and community coordination. And most importantly, the announcement is carefully designed to maximize excitement for the game. That entire process was supposed to be driven by Mr. Gill. However, in defiance of the Court’s Opinion, Krafton has now taken that away, further damaging the game and sowing additional confusion among the Subnautica community. The lawyers speculated that Krafton had “intentionally leaked” Papoutsis’ memo and then issued an official statement to confirm the leak. Game File is a reader-supported publication. My reporting is only possible through support from readers like you. To support my work, consider becoming a free or paid subscriber. Subscribe On Wednesday, lawyers for Krafton defended their client in their own letter to vice chancellor Will, saying nothing they did violated her order nor showed contempt: Papoutsis’s message was simply celebrating the UW employees’ efforts toward a past event: Krafton’s pre-Opinion determination that Subnautica 2 was ready for Early Access release. There was nothing improper about conveying the results of the milestone review or thanking the development team for their dedication and talent. They added that Gill could still make his own call about Subnautica 2’s release: In his role as CEO, Gill will be able to assess independently his views on the state of Subnautica 2 and the appropriate release schedule; nothing in Papoutsis’s message alters Gill’s authority or discretion. Vice chancellor Will has not responded to the letters and doesn’t necessarily have to. Both parties were previously ordered by Will to confer this week and submit a proposed judgment consistent with her ruling. The letter from Gill’s attorney’s this week doesn’t indicate whether he would or would not support a May release for Subnautica 2. But it could limit his options. And, if Gill’s lawyers are right, the lack of marketing fanfare around the leak of the May date could dull the launch of the game. Any harm to Subnautica 2’s launch is an extra sensitive issue given the context of the legal dispute: millions of dollars of payouts are on the line, tethered to the scale of the game’s initial performance. In her ruling on Monday, Will noted that there was obvious “bad blood” between Gill’s side and Krafton but that the two would need to work together: “They can—and must—act in good faith to navigate their remaining contractual relationship.” Item 2: A new kind of couch co-op game A highlight of GDC each year is the Alt.Ctrl showcase that features games played with extremely experimental controllers. Perusing this year’s offerings last Friday, I found a game controlled with giant scissors, another with big toothbrushes and one that amounted to dumpster diving. My favorite was Pivot, a co-op game about collectively maneuvering a couch. It was developed by students at the University of Utah’s masters of arts and engineering games program. Players lift and tilt the physical couch in order to control the position of a virtual one. That virtual one is moving through an obstacle course on-screen, while being pursued by a giant skull. Developer Nishant Verma told me at GDC that the couch is made of styrofoam (this became more evident as I watched!) and that the name was a riff on an episode of the sitcom Friends. Item 3: In brief… 🚫 Ubisoft is laying off more than 100 workers at its Red Storm studio, as the North Carolina location known for decades for its Tom Clancy games, ceases in-house game development, VGC reports. 👀 On Monday, Nvidia’s revealed its DLSS 5 AI-driven graphics technology that purports to improve game graphics… and it has been roasted about it by the media and the online gaming public for the remainder of the week. The tech changed the faces of characters in footage from Resident Evil Requiem, Hogwarts Legacy and EA Sports FC, drawing accusations of giving carefully art-directed games the generic look of AI “slop.” Nvidia CEO Jensen Huang had said on Monday that “DLSS 5 is the GPT moment for graphics—blending handcrafted rendering with generative AI to deliver a dramatic leap in visual realism while preserving the control artists need for creative expression.” By mid-week, Huang was telling Tom’s Hardware that the new tech’s critics were “completely wrong” because game-makers could still “fine-tune the generative AI” to suit their game’s aesthetics.
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