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Sheldon Middle School Students Do Well At State Science Fair
Sheldon, Iowa — Sheldon Middle School students wrapped up another successful year at the State Science and Technology Fair of Iowa (SSTFI) last week. The fair was held at Hilton […]
The most successful health campaign in modern history
How one number explains how we’re winning the 60-year war on smoking.
Maria Elvira Salazar part of successful petition forcing House vote on TPS for Haitians
She will spearhead a similar effort with Darren Soto to grant Venezuelans the same treatment.
Here’s the Morgan Park Picnic entertainment lineup
n case you missed the news, Milwaukee Record and Busby’s will once again be joining forces to bring the city a full-fledged spring festival. Yes, following a successful debut in 2025…
Alaska politics + Winston College of Law + Blotter ++
In Alaska, when politicians talk about the NPR, it’s not National Public Radio. It’s the National Petroleum Reserve. And on March 18, 2026, Alaska’s Republican senators, Lisa Murkowski and Dan Sullivan, issued a press release taking credit for the “most successful oil and gas lease sale ever held in the National Petroleum Reserve-Alaska (NPR-A).” It […]
Lost in space: Microgravity makes sperm lose their sense of direction
Making babies in space may be more complicated than expected, as new research shows sperm struggle to navigate in microgravity. Scientists found that while sperm can still swim normally, they lose their sense of direction without gravity, making it harder to reach and fertilize an egg. In lab experiments simulating space conditions, far fewer sperm successfully made it through a maze designed to mimic the reproductive tract, and fertilization rates in mice dropped by about 30%.
Chris Kelly Opinion: A petition for better acting in politics and PR
“Memory, all alone in the moonlight/ I can dream of the old days/ Life was beautiful then…” – from “Memory,” by Andrew Lloyd Webber Successful theatrical productions achieve the “suspension of disbelief,” temporarily convincing audiences th…
Phil Weiser wins top spot in Colorado’s Democratic gubernatorial primary at party’s state assembly
Attorney General Phil Weiser’s name will appear first on Colorado’s Democratic gubernatorial primary ballot after his overwhelming win Saturday at the party’s state assembly in Pueblo. Weiser joins U.S. Sen. Michael Bennet in the June 30 primary for the office held by term-limited Gov. Jared Polis. Bennet, who successfully petitioned onto the ballot, didn’t participate […]
Another global health crisis is gaining momentum. We need to be prepared.
The PASTEUR Act has been proposed to create a subscription-style model between the federal government and companies that successfully develop novel antimicrobials, in order to ensure access to life…
My son and I built a successful business together, but we fought a lot
We built a successful business on Amazon, using the revenue to pay for my son's college tuition. But we couldn't agree on the company's direction.
It Sucks to Work in the Video-Game Industry Right Now
Even developers who successfully release big hits, like Fortnite and Battlefield, are losing their jobs
Apple Says No iPhone in Lockdown Mode Has Ever Been Hacked
Apple says it has no record of a successful spyware attack against any device running Lockdown Mode, the opt-in security feature it introduced in 2022. "We are not aware of any successful mercenary spyware attacks against a Lockdown Mode-enabled Apple device," an Apple spokesperson told TechCrunch. Lockdown Mode is available on the iPhone, iPad, and Mac, and dramatically restricts certain system features that are commonly exploited by mercenary spyware.
Antimatter took to the road for the very first time. Here’s why it matters
Scientists successfully transported a minute quantity of antimatter for the first time, opening up new possibilities for the study of the world’s most expensive substance.
Apple says no one using Lockdown Mode has been hacked with spyware
The tech giant's claim that it has not seen any successful spyware attacks targeting Apple devices with Lockdown Mode enabled comes amid a leak of hacking tools targeting users running devices with older software.
Vanderbilt Lung Transplant Program sets new record
The Vanderbilt Transplant Center is now the second largest lung transplant center in the United States by volume, with 149 lung transplants in 2025, the most ever in one year at Vanderbilt Health. The Vanderbilt Lung Transplant Program leads the nation in organ preservation and regeneration and is among the best in long-term outcomes, demonstrating the success of the interdisciplinary team in caring for these complex patients. Several features make the program unique in the United States, said Konrad Hoetzenecker, MD, PhD, professor of Thoracic Surgery and surgical director of the Vanderbilt Lung Transplant Program. Vanderbilt serves as a “second opinion center” and accepts most complex candidates that are turned down by other centers due to increased perioperative risk. This includes patients over 70 years old, patients requiring combined procedures with their transplant, multiorgan transplantations and sensitized patients (individuals who have pre-formed anti-HLA antibodies who are at higher risk for complications). The expertise and excellent outcomes have attracted patients far beyond the borders of Tennessee; almost half of Vanderbilt Health’s lung transplant recipients come from out of state. “Another unique feature is our minimally invasive transplant program,” Hoetzenecker said. “By using distinct surgical instruments and techniques, the incisions can be kept as small as 7 to 8 centimeters, which results in better healing, less pain and faster recovery. “This minimally invasive approach is embedded in an Enhanced Recovery After Surgery (ERAS) protocol, a multimodal, evidence-based perioperative care pathway designed to reduce surgical stress, minimize complications and speed up recovery. Our unique ERAS protocol, by a dedicated interdisciplinary approach, aims to improve recovery after lung transplant and reduce ICU and hospital stay.” The lung transplant program recently celebrated a milestone — 1,000 lung transplants since the program began in 1990. “This significant achievement reflects the concerted effort of a multidisciplinary collaboration by the Departments of Thoracic Surgery, Medicine, Anesthesiology and Critical Care,” said David Erasmus, MD, associate professor of Medicine and medical director of Vanderbilt Lung Transplant. Lung transplants have been attempted since the 1960s, but they were largely unsuccessful until the 1980s, when surgical techniques were refined and new antirejection drugs proved effective. Patient outcomes steadily improved from the 1990s to the present. Vanderbilt’s fourth lung transplant recipient in 1990, Pam Everett, is the longest-living, single-lung transplant known in the world, recently celebrating 35 years since her transplant. The Vanderbilt Lung Transplant surgical team is led by Hoetzenecker and Caitlin Demarest, MD, PhD, the surgical director and associate surgical director of the Vanderbilt Lung Transplant program. Erasmus is the medical director of Vanderbilt Lung Transplant along with Anil Trindade, MD, associate medical director and associate professor of Medicine.
Lakers return home from successful trip to face spiraling Nets
Lakers return home from successful trip to face spiraling Nets
/C O R R E C T I O N -- Alliance for Creativity and Entertainment (ACE)/
The Alliance for Creativity and Entertainment (ACE), the world's leading anti‑piracy coalition, has successfully shut down AnimePlay, one of the largest illicit anime streaming applications operating in the Asia-Pacific region. The application was run out of Riau, Indonesia.
Scientists Successfully Unfroze Part of a Mouse Brain—and It Still Worked
We’re a long way from reviving a frozen human, but new research yields insight.
From Trump to Dr. Oz: 10 reality TV personalities who went into politics
These reality stars either began their careers on TV or dipped into it later, but they all also tried their hand at politics — some more successfully than others.
Milledgeville teen runs car detailing business in school, wins $1,000 in chamber contest
At 19 years old, Kyan Silas has started a successful business and received second place in the youth entrepreneur program, landing him a $1,000 prize.Kyan Sila
Manor Township Democratic committee person kicked off May 19 primary ballot
Kirk Barrett, a candidate for a Manor Township seat on the Lancaster County Democratic Committee, has successfully kicked the incumbent’s name off the ballot for the upcoming May 19 primary.
How LuGus Studios Turned a Viral Prototype Into a Successful Business
LuGus Studios discusses building Liftoff, growing a niche drone sim audience, and sustaining a 15-year indie studio through community-driven development, iterative workflows, and a focus on impact over scale.
UCLA tries to enjoy rare opportunity for Lauren and Sienna Betts
UCLA works to celebrate Lauren and Sienna Betts as successful sisters and individual playmakers pushing to help the Bruins win.
How to beat Gigantamax Pikachu: Best Counters & Guide
Gigantamax Pikachu is a Tier 6 Max Battle in Pokémon GO. It will cost 800 Max Particles to participate in this Max Battle, which will only be consumed if you defeat Pikachu successfully. Gigantamax Pikachu can be shiny from Max Battles. Being an type, it is only weak to type moves. Pikachu can be caught […]
Staff revolts, secret meetings: Inside the tense fight between Mike Pence and the Heritage Foundation
Mike Pence used to dream of following two successful Donald Trump terms with his own turn in the White House.
B.C. recruits 400 healthcare workers, most from Washington and Oregon
A successful targeted campaign recruited more than 400 U.S.-trained healthcare professionals to British Columbia, many of whom are from Oregon and Washington.
Your Thymus and Your Healthspan
Our thymus gland plays a central role in the development or our immune system, specifically for supporting T cell development (how these cells got their name, maturation and differentiation in the thymus) and discriminating between self and foreign, non-self antigen proteins with production of dendritic cells. As we age, our thymus gland shrinks—the process known as involution—with progressive change from spongy to fatty tissue, with loss of functionality. But this process, with respect to timeline and extent, markedly varies from one person to the next. And to make things even more complicated, our thymus gland anatomy and precise location in the chest also is highly variable. So the famous Frank Netter diagrams from the 1960s (such as at left below) don’t capture the remarkable heterogeneity that a random set of 12 chest CT scans (below at right). What I consider as 2 landmark papers in Nature this week (here and here) used AI to quantify health of the thymus in 2 large cohorts, and then correlate the metric to a broad array of health outcomes. In this edition of Ground Truths, I’m going to cover three questions: (1) How was thymus health determined by AI?; (2) How is thymus health linked to key clinical outcomes? and (3) Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? Subscribe 1. How was thymus health determined by AI? This was accomplished by extensive work developing and validating an AI pipeline for 2 stages, the first for localization and segmentation of the thymus bed, and the second to quantify a digital marker, termed the thymic health score. There’s a lot to this algorithmic development, so I won’t go into all the details, but just provide a rudimentary outline of what was done. The 1st stage used supervised learning with 2 radiologists reviewing 2,461 chest CT scans. That work trained a 3D U-Net model to automatically identify the thymic bed’s 3D cropped region using center of mass coordinates, which reached 99.8% accuracy. The 2nd stage used a foundation model that was pre-trained with SwAV (which stands for Swapping Assignment between multiple Views), a self-supervised model, that generated a high-dimensional thymus representation of 4,096 features. That compares to the radiology reductionist and subjective scoring of 0 to 3 where 0 means the thymus is fully degenerated and fatty, and 3 is considered dense, intact glandular soft tissue. Notably, the self-supervised learning (SSL) performance was superior to supervised (AUC ~0.75 vs 0.55, respectively) reflecting the shallowness of the 0-3 classifier vs SSL’s holistic, self-taught AI. The thymic health score ranged from 0 to 100, with the highest number indexed to fully preserved thymic health. The algorithmic work extended to explainability with both Shapely value distribution, meaning the model was holistic not relying on any “magic” pixel, and occlusion sensitivity, demonstrating the model’s performance was not affected by ribs, sternum, lung tissue, but rather focused on the thymic bed directly. Below are a few saliency maps from the occlusion sensitivity that indicate the thymic bed focus, not affected by neighboring structures, using the jet color scale. Now the AI was ready for processing ~25,000 CT scans, each over 30 MB files, from the 2 large participant cohorts to provide a thymic health score, it did so in less than 14 hours, which is less than 2 seconds per scan! Share 2. How is thymus health linked to key clinical outcomes? The two cohorts were the National Lung Screening Trial, NLST (N=25,031) and the Framingham Heart Study, FHS (N=2,581) each with baseline demographics and long term follow up of >12 years for health outcomes. From the NSLT, you can see below that increased age and body-mass index were correlated to reduced thymic health. And, overall, men had reduced thymic health scores compared with women. There are a lot of graphs in the paper for outcomes, for both the NLST and FHS cohorts. To simplify the major outcomes, below is a composite Figure with striking reduction of all-cause mortality and for the different causes of death. The results were consistent between the 2 cohorts. For example, the cardiovascular mortality hazard ratio average was 0.57 in NLST and 0.38 in FHS (weighted to be 0.53 for the aggregate). The reduction of mortality also extended to digestive diseases and pulmonary disease (data not shown below). Lung cancer incidence was reduced by 36% for high vs low thymic health (Figure below, with a panel -incidence and b panel-mortality, adjusted for age, sex, BMI, smoking status). Notably, there was a smoker’s paradox: lower incidence and improved survival for lung cancer in smokers who had a high thymus health score. Smoking was associated with lower thymic scores whereas alcohol was not. Higher thymic health was linked to higher HDL cholesterol, lower triglycerides, lower fasting blood glucose, and lower systolic and diastolic blood pressure. Inflammation biomarkers, such as C-reactive protein and interleukin-6, were elevated in the people with lower thymic health scores. In their second paper, the same team looked at the relationship between thymic score and outcomes for 3,476 patients receiving cancer immunotherapy. The non-small cell lung cancer progression-free survival was reduced in patients with low thymic health score. A parallel relationship for survival was seen for other types of cancer including melanoma, breast, and kidney with a 44% lower risk among high thymic scores (Figure). A similar pattern was seen with different immune checkpoint inhibitors. The thymus health score outperformed programmed death ligand-1 (PD-L1)and tumor mutation burden (TMB) assay of the tumor and was an independent prognostic marker of progression-free survival. In this dataset, a direct connect with thymus score and adaptive immune function was noted with a correlation before cancer treatment for both T-cell diversity and thymus T-cell production (a metric known as T cell receptor excision circles). Thymus Removal Study There is a highly relevant citation about thymus function before moving onto ways to rejuvenate it. In 2023, a very important study of thymus removal during cardiothoracic surgery was published, with 1146 patients undergoing thymus removal vs 1146 matched controls (mean age 55 years). The adverse outcomes for thymus removal were striking, with a 2.9 higher risk of all-cause mortality and doubling of cancer incidence, 1.5 fold increase in cancer mortality, and 1.5-fold increase in autoimmune diseases. The immune function showed marked compromise after thymus removal, as reflected by CD4+ and CD8+ T cells (Figure below) Share Ground Truths 3. Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? In recent months we’ve learned a lot about the process of thymus involution and the pathways by which this may be modulated. Thymus involution is primarily due to loss to thymus epithelial cells (TECs) and there are 2 subtypes with different functions: the cortical, responsible for positive selection of T cells, and the medullary, for negative selection. When adipose tissue infiltrates the thymus, thymic adipocytes are pro-inflammatory, knocking out T-cell output. Likewise, systemic inflammation, or “inflammaging,” from smoking, obesity, and chronic stress promote thymic adipocytes. Now, from preclinical studies, we know about key pathways that account for these processes. Historically, back in 2014, FOXN1 was recognized as a single master transcription factor essential for TEC function, with studies in mice with forced FOXN1 upregulation leading to thymus regeneration. That laid the foundation for potential regrowth of quiescent thymus cells. It took awhile to find pathways to accomplish this goal and to even refute its role as the master regulator. The Liver-Thymus Axis Feng Zhang and his team recently showed that injection of an mRNA vaccine to the liver encoding DLL1, IL-7 and FLT3-L in combination, factors known to support thymopoiesis (Figure), successfully enhanced immune function in aged mice. However, the effect was transient. The FGF21 Story Two reports in 2025 addressed the thymus gland’s production of FGF21, a growth factor (fibroblast growth factor 21) and its control of thymus involution. This growth factor is also produced by the liver, but it doesn’t have impact on the thymus in aged rodent models. In contrast, The liver’s hepatocyte growth factor (HGF) has been shown to reverse senescent TEC structural changes. Growth hormone stimulates production of insulin growth factor-1 (IGF-1) in the liver and the thymus. Two small studies in human participants (TRIIM, for Thymus Regeneration, Immunorestoration, and Insulin Mitigation) of 6 and 50 people, respectively, treated with combined human growth hormone, metformin and DHEA, suggested the potential of slowing epigenetic aging and improving thymus mass and function. But the combination of drugs, small sample, and lack of controls make conclusions murky. Increased thymus FGF21 led to increased CD8 T cells in old mice and extended healthspan and improved physical performance. Building on the previous FOXN1 data, ablation of β-klotho, the obligatory co-receptor for FOXN1, accelerated thymic aging. The benefit to FGF21 was confirmed in a companion paper using an FGF21 knock-in mouse model showing thymus enlargement and increased TECs throughout the lifespan. (schematic Figure below). The accompanying editorial for these 2 papers speculated: “The proposed link between age-associated thymus involution and organismal aging is intriguing, and suggests we might seek to achieve systemic rejuvenation by counteracting thymic involution.” Other Factors Lessons from the Axolotl (Mexican Salamander) In an elegant set of experiments of the axolotl (Figure), known for its complete thymus regeneration after total surgical removal, mediators were identified. Surprisingly FOXN1 was dispensable. But midkine, a growth factor, appeared to be the driver, the initiator of thymus cell growth, survival, and repair. Other components that contributed were Postn+ (periostin-expressing mesenchymal niches) and Ccl19, a chemokine protein from the bloodstream. RANK and RANKL RANK (receptor activator of nuclear factor κB its ligand (RANKL) have been considered key regulators of medullary TECs. In a study of both aged mice and human thymus cell cultures, their key role was confirmed, with multiple benefits of resorting TEC function, recruitment of progenitor cells, and T cell development. Subscribe Summing Up This body of work strongly supports the health of the thymus gland as a critical regulator of human healthspan, not just a correlate or link. The new landmark studies are reinforced by the regenerative biology experimental models that have shown, via an array of mediators, that healthspan of aged mice is at least in part dependent on thymus gland function and its critical role for maintaining adaptive immunity. It sure seems that we’d be better off having an immune reservoir of naive T cells instead of a profile in older adults of exhausted, low quality, memory T cells, with a senescent phenotype. It is striking that we ignored the importance of the thymus gland for many decades. A wake-up call was the results of the thymectomy matched control study reviewed here, with the opposite of high thymic health score improved health outcomes. The convergence of AI and healthspan here is notable. The exceptional and laborious work for developing and validating (no less explaining) the AI to quantify thymus health set the foundation for probing the connect the major health outcomes in two cohorts with extensive follow-up. We’ve never had a way to meaningfully quantify the thymus gland before, so this represents important leverage of supervised, self-supervised, and transformer models. The study wouldn’t have been possible without AI. And it begs the question as to whether there are ways we can maintain our thymus at a high health score. But it’s not so simple to rejuvenate our thymus. There are multiple risks including the induction of autoimmunity, increasing the risk of cancer, and inducing a pro-inflammatory state. For example, factors that increase TEC proliferation could compromise the medulllary negative selection process and leak out auto-reactive (self-attacking) T cells. Thymic cells could be induced to proliferate, but we know, for example, that growth hormone and IGF-1 are associated with an increase risk of cancer. If thymus rejuvenation doesn’t clear out the accumulated senescent cells in older adults, then inflammation within the gland could block the production of TECs. Keeping these risks in mind, we now have identified many ways to keep our thymus healthy as we age that undoubtedly will be tested in clinical trials going forward. Ultimately, the benefit-to-risk tradeoffs will be defined. In the meantime, we have desperately needed an immunome. As I’ve stressed in multiple prior Ground Truths, we have no test in the clinic to assess a patient’s immune status! It was very encouraging for me to get an email from Hugo Aerts, the senior author of the landmark papers in the days after they were published: “I also wanted to say that your Substack on “Why We Need an Immunome” was inspiring for this work. We found it a very compelling perspective and greatly enjoyed reading it.” Just having an assessment of a person’s immune status via a chest CT scan, with millions of these performed per year, might help in guiding the right immunotherapy for cancer (e.g. more intensive, combinations for those with low thymic health scores) and help define people who are increased risk for age-related diseases of cancer, cardiovascular, and neurodegenerative. The main theme of Super Agers is that we now have many layers of data (genetics, proteins, biomarkers, organ clocks that can be integrated via multimodal AI) for us to define a person’s specific risk decades before one of these age-related diseases leads to symptoms, enabling prevention. From the new studies this week, we can add thymus health score as yet another way to understand a person’s risk, a window into their adaptive immune system and healthspan. And perhaps someday we will be able to safely rejuvenate the thymus, or maintain its health through one’s life, and use the thymus health score to monitor. NB: I wrote this post (No A.I.) A Quick Poll Loading... ********************************************************************* Thanks to Ground Truths subscribers (now > 200,000) from every US state and 212 countries. Your subscription to these free essays and podcasts makes my work in putting them together worthwhile. Please join! If you found this interesting PLEASE share it! Share Ground Truths Paid subscriptions are voluntary and all proceeds from them go to support Scripps Research. They do allow for posting comments and questions, which I do my best to respond to. Please don’t hesitate to post comments and give me feedback. Let me know topics that you would like to see covered. Leave a comment Many thanks to those who have contributed—they have greatly helped fund our summer internship programs for the past two years. It enabled us to accept and support 47 summer interns in 2025! We aim to accept even more of the several thousand who will apply for summer 2026.
Anthropic just shipped an OpenClaw killer called Claude Code Channels, letting you message it over Telegram and Discord
The consensus among early adopters is that Anthropic has successfully internalized the most desirable features of the open-source movement—multi-channel support and long-term memory
Del Monte Foods Successfully Completes Sale Transactions Across All Business Segments
/PRNewswire/ -- Del Monte Foods Corporation II Inc. (the "Company" or "Del Monte Foods"), a leading producer, distributor, and marketer of premium quality,...
Interventional radiology breakthrough in portal vein thrombosis treatment
A UCLA Health interventional radiologist has successfully performed the first pediatric percutaneous spleno-renal shunt procedure to treat severe portal hypertension in a 6-year-old patient. This minimally invasive procedure aims to relieve complications associated with portal vein thrombosis, showing promising long-term outcomes.
Frameshift: How Caitlin Vander Weele made science communication her business
Her favorite part of research was talking about it. So she left academia and turned that passion into a successful company.
Frameshift: How Caitlin Vander Weele made science communication her business
Her favorite part of research was talking about it. So she left academia and turned that passion into a successful company.
Gen Z Loves This Old-School Way of Shopping — But With a Twist: ‘Lines Out the Door’
Successful brands are meeting their young consumers where they want to be.
Scientists just discovered a tiny signal that volcanoes send before they erupt
A new detection method called “Jerk” could dramatically improve how scientists forecast volcanic eruptions. By using a single broadband seismometer, the system can detect extremely subtle ground movements caused by magma pushing underground—often hours before an eruption begins. Tested for more than a decade at the Piton de la Fournaise volcano on La Réunion, the tool successfully predicted 92% of eruptions between 2014 and 2023, sometimes giving up to eight hours of warning.
Successful Business Development Is All About Authenticity
Cravath and Debevoise’s former chief marketing officer, Deborah Farone, shares insights into business development from top women lawyers.
After a successful launch weekend, Pokopia has become one of the best-selling Pokémon spin-offs ever
It is fair to say Nintendo's new Animal Crossing-like Pokémon Pokopia has had a pretty darn successful launch.
Microsoft Confirms SQL Zero-Day Security Vulnerability—Here’s The Fix
Microsoft has confirmed that a hacker who successfully exploits a zero-day SQL vulnerability could gain system administrator privileges. Here’s how to fix it.
6 Things To Know Before Starting A Business In Panama
I've built a successful business in Panama over the past two decades. Here are my six tips for prospective entrepreneurs.
UI Health Care performs its first robotic living donor nephrectomy
University of Iowa Health announced in early February 2026 that it had successfully completed its first robotic living donor nephrectomy
Small businesses that successfully sued over Trump tariffs relaunch fight against new levies
Gave up traveling full-time with family, successful YouTube career
I traveled full-time with my family for years and posted on YouTube. We gave up that lifestyle, but I worry about the negative impacts on our kids.
Luka Doncic issues stern challenge after Knicks win
Lakers star Luka Doncic spoke about what the team needs to continue to do in terms of defense to be successful.
Women in Science: Alice Schlichtiger on Leadership, Mass Spectrometry, and Impact
In this interview, Dr. Alice Schlichtiger discusses her journey from academia to industry and shares her advice on building a successful career in science.
Apple's Strange TikTok Videos Capturing Gen Z's Attention
Apple is promoting the MacBook Neo with a series of intentionally strange TikTok videos that are successfully capturing Gen Z's attention. Since Thursday, Apple has been posting the videos in sets of three, with each video corresponding to one of the MacBook Neo's Blush, Citrus, and Indigo color options. The laptop also comes in Silver, so there may be a final set of videos tomorrow.
NASA successfully kicks asteroid off course in Earth defence test
NASA knocked an asteroid off course in 2022 in a pioneering test of humanity's ability to defend Earth. Its spacecraft's impact pushed the space rock into a slightly different orbit around the Sun, according…
Slay the Spire 2's launch has been so incredibly successful, the studio had to apologise for a joke about Marathon that now "seems a bit meaner than it was intended"
Game developer behind Slay the Spire 2 has assured people that their congratulations message to the Marathon team wasn't meant to read as mean.
A little butter and a lot of passion: Black Box Bakery perfects the recipe for a successful small business
Black Box Bakery opened in the Edgewater Public Market and has quickly become known as one of the top bakeries in the Denver area. How did they do it? With professionals who take pride in their work.
Scientists Cut Amyloid Plaques by 50% in Mice With Engineered Cells
"This study marks the first successful attempt."
How a successful Colorado startup turned into a nearly $1 billion health care fraud scheme
Zynex served as a Colorado startup success story — a one-man operation turned public company with hundreds of millions of dollars in revenue. This is the story about how it all fell apart.
How Mixed-Use Sports and Entertainment Districts Create Year-Round Economic Value
From stadium-anchored destinations to experience districts, successful mixed-use sports and entertainment developments are evolving into adaptable, community-centered places that deliver cultural relevance, financial performance, and economic activity every day.
TransUnion Completes Acquisition of Majority Ownership of the Consumer Credit Business of Buró de Crédito
TransUnion (NYSE:TRU) has successfully completed its previously announced acquisition of an additional 68% of Trans Union de México, S.A., S.I.C., the consumer credit business of Buró de Crédito, the largest credit bureau in Mexico. The transaction brings TransUnion’s total ownership to approximately 94%. TransUnion will operate this busine...
TransUnion Completes Acquisition of Majority Ownership of the Consumer Credit Business of Buró de Crédito
CHICAGO, March 02, 2026 (GLOBE NEWSWIRE) -- TransUnion (NYSE:TRU) has successfully completed its previously announced acquisition of an additional 68% of Trans Union de México, S.A., S.I.C., the consumer credit business of Buró de Crédito, the largest credit bureau in Mexico. The transaction brings TransUnion’s total ownership to approximately 94%. TransUnion will operate this business under the commercial name of Buró de Crédito going forward. Cash consideration for the transaction is approxima
No business succeeds alone and that’s why mentorship matters
I’ve never met a successful business owner who truly did it alone. Not one. Behind nearly every thriving business is someone who stepped in at the right moment, a person who shared experience, offered perspective, or simply provided reassurance when things felt rocky. When I talk with new business owners today, I hear that same […]
7 Ways To Use Your Instinct To Grow Your Business Faster
Learn why successful founders trust gut instinct over data. Howard Schultz, Elon Musk reveal how intuition beats analytics for major business decisions.
Business Victories in the 2026 Legislative Session - Indiana Chamber of Commerce
Indiana State Capitol Building in Indianapolis, Indiana, USA. Our president and CEO Vanessa Green Sinders says the 2026 Indiana General Assembly, which adjourned last evening, was "successful in advancing key Indiana Chamber priorities and building on the state’s momentum to keep Indiana on a
New downtown Portland small businesses are thriving after successful runs as pop-ups
ContextLogic Completes $907.5 Million Acquisition of US Salt, Marking Transformation into Business Ownership Platform
Transaction Creates Leading Public Business Ownership Platform with Strong Cash Generation and Approximately $2.9 Billion in NOLsOAKLAND, Calif., Feb. 26, 2026 (GLOBE NEWSWIRE) -- ContextLogic Holdings Inc. (OTCQB: LOGC) (“ContextLogic,” the “Company,” “we” or “our”) today announced the successful completion of its acquisition of US Salt Parent Holdings, LLC and its subsidiaries (collectively, “US Salt”) from private equity funds managed by Emerald Lake Capital Management (“Emerald Lake”) in a t
Business Development is Not Magic! How Successful Lawyers Build Thriving Practices
Sustainable practice growth requires intentional strategy, authentic engagement, disciplined follow-up, and a long-term relationship mindset.
Carolina Celebrates Successful National Girls & Women in Sports Day - University of North Carolina Athletics
CHAPEL HILL, N.C. – Carolina Athletics spotlighted National Girls & Women in Sports Day on Sunday morning, hosted at the Bill Koman Practice Complex. The ann...
Meet the 20 most successful M&A bankers of 2025
The top US merger banker last year hails from Wells Fargo. Meet him and 19 other dealmakers who who shaped the $4.6 trillion M&A comeback.
Like Trump nationally, incumbent Colorado Dems lose sight of what matters to everyday people
My years as a high-level radioactive waste manager took me in and out of Washington, D.C. frequently during the 1990s. Following Newt Gingrich’s successful 1994 ouster of the Democratic majority in Congress, following their 40-year reign, I was surprised many Democratic lobbyists were willing to acknowledge privately Newt’s win was probably a good thing. There […]
Kimberly's INcubator program turns student ideas into real businesses
Kimberly High School's INcubator program teaches students all aspects of building a successful business.
Want to Raise Successful Kids? Science Says Teach Them to Avoid This Common Habit
Habits that feel most ordinary today often matter the most in years to come.
Scientists successfully mine meteorites on International Space Station
Can we use fungus to mine precious metals from asteroids?
3L Ediz Kalkan Builds Practice-Ready Skills through UC Law SF’s Business Law Concentration - UC Law San Francisco (Formerly UC Hastings)
3L student Ediz Kalkan combined rigorous coursework, mentorship, and hands-on client experience to emerge ready for corporate practice. 3L student Ediz Kalkan shares how UC Law SF’s Business Law Concentration helped him gain the practical skills, doctrinal knowledge, and professional confidence to pursue a career advising corporate clients. It’s one of 12 concentrations that allow JD students to gain specialized expertise in a focused area of legal practice. 3L Ediz Kalkan built a strong foundation in corporate law through specialized coursework and mentorship from faculty and industry leaders. He gained hands-on client experience advising startups through the Startup Legal Garage and through roles in-house and at a law firm. He emerged prepared to handle sophisticated legal matters and interact confidently with clients. 3L Ediz Kalkan: I always gravitated toward business law courses at UC Law SF, so it made sense to memorialize that interest by completing the concentration — especially since I already planned to take most of the required coursework. I have taken many practical- and doctrinal-focused courses, including practical-oriented courses such as Mergers and Acquisitions, Venture Capital and Start Ups, Startup Business Lawyering, Private Equity and Hedge Funds, Corporate Governance, Corporate Finance and a few others. On the doctrinal side, I have taken Business Associations and am currently enrolled in Bankruptcy and Securities Regulation. These courses and professors equipped me with a strong foundation in universal corporate legal principals, fluency in the jargon, and insight into how corporate law intersects with markets, public and private companies, and government agencies. I also gained invaluable mentorship and lessons from industry leaders — both from the faculty and the dozens of guest speakers invited to the classroom. At UC Law SF, I participated in the Corporate Module of the Startup Legal Garage, where I observed practicing attorneys and helped real clients with real startup-related legal needs. I learned substantive law, business strategy — and most importantly — was socialized to the practice of law and the etiquette and expectations of being a junior attorney. I spent my 1L summer at AXOS Bank, a commercial bank in San Diego, where I gained experience with securities regulation, enterprise banking, and in-house work at a public company. From January of my 2L year to now, I have worked as a law clerk at Bartko Pavia LLP, gaining experience in a traditional law firm setting. I have had the privilege of working with startups all the way to public companies, as well as international clients. The experience has strengthened my confidence in tackling complex legal issues and interacting with clients. Through these experiences, I’ve learned that effectively advising clients takes more than subject-matter expertise. This work, and my time in the UC Law SF business concentration, have inspired me to pursue an MBA after law school to become a more well-rounded professional. My career plans remain focused on corporate practice and enhancing my value as a business advisor. I would happily recommend UC Law SF and this concentration because of its robust course catalog, highly successful professors and adjuncts, and extensive resources. Not to mention, UC Law SF is uniquely situated just minutes away from many of the world’s most innovative companies, all of which have legal needs — creating meaningful opportunities for students. My peers and I have been incredibly fortunate to have access to this network of industry leaders and legal professionals. Ultimately, business lawyers can take many paths, but all require the strong foundation that the business law concentration and the incredible people at UC Law SF provide. The Evidence of Success series highlights UC Law SF students as they share how the college’s opportunities equip them with the experience, skills, and confidence to excel in the legal profession.
From bartending to business owner: one man's $3 million success story
Richard Boccato turned his bartending career into a successful, multimillion-dollar ice business serving top NYC bars and restaurants.
How the lightning strikes of nuclear science will fill foundational radiation research gaps
One path to becoming a successful researcher is to find an under explored scientific niche and add knowledge where it didn’t exist before.
DAV announces new partnership with Solace Health supporting veterans’ care
ERLANGER, Ky. – DAV (Disabled American Veterans) is proud to announce a new partnership with Solace Health as its first new partner in 2026. The partnership is supported by a donation from Solace Health to advance DAV’s mission of empowering veterans to lead high-quality lives. The collaboration brings together two organizations focused on helping veterans receive timely, coordinated, high-quality care, regardless of where they receive it. While many veterans receive care through the VA, which offers an integrated and coordinated whole-health model, others receive some or all of their care through private health systems using Medicare or other insurance benefits. These veterans often need help to understand health insurance rules, manage their treatment, and navigate between multiple health care systems. “Disabled veterans often have complex health challenges, and DAV’s advocacy work strives to minimize barriers to timely, high-quality care, primarily within VA., but increasingly between VA and private providers,” said DAV CEO and National Adjutant Barry Jesinoski. “Our partnership with Solace Health can offer support for veterans who are eligible for VA care and Medicare, particularly those who split their care between the VA and private health systems. Veterans who don’t use VA at all can also benefit from the care coordination services that Solace Health provides, usually with little or no out-of-pocket cost to them.” Solace Health provides professional health care advocacy services, connecting patients with experienced advocates who help schedule appointments, explain benefits, coordinate care among providers, and manage administrative burdens with private health care systems, thereby allowing veterans and their families to focus on health and recovery. “For many veterans, the fight doesn’t end when service does,” said Jeremy Gurewitz, CEO and co-founder of Solace Health. “Veterans living with serious medical conditions often encounter a private health care system outside of the VA that is fragmented and difficult to navigate. Through this partnership with DAV, Solace Health advocates can help cut through red tape, improve care coordination, and simplify scheduling of medical appointments. We’re proud to support DAV in helping veterans to successfully navigate health care systems so that veterans, particularly disabled veterans, receive the care they have earned.” DAV provides a lifetime of support for veterans of all generations, their families, caregivers, and survivors. Each year, DAV’s no-cost programs and services help more than 1 million veterans access the benefits and health care they have earned, connect with meaningful employment, and ensure their voices are heard on Capitol Hill. About DAV DAV is dedicated to ensuring our promise is kept to America’s veterans. DAV does this by helping veterans and their families access the full range of benefits available to them, fighting for the interests of America’s injured heroes on Capitol Hill, providing employment resources to veterans and their families, offering programs and services to empower them, and educating the public about the great sacrifices and needs of veterans transitioning back to civilian life. A nonprofit organization with nearly 1 million members, DAV was founded in 1920 and chartered by the U.S. Congress in 1932. About Solace Health Veterans face complex health challenges, and the path to care is far harder than it should be. They deal with fragmented services and providers, each with unique requirements and paperwork. Solace Health advocates—healthcare experts with 16 years’ experience on average—help veterans navigate this landscape when they need it most. Advocates schedule appointments, explain benefits and keep doctors aligned. They take the lead on calls and documentation, and their no-homework ethos eases burdens on veterans and their families. Solace Health is covered by Medicare and Medicare Advantage, and most veterans pay little or nothing out of pocket. We’re honored to support DAV members.
Scientists build successful 'cloud in a box'
In a quiet laboratory, a team of atmospheric scientists and engineers at the U.S. Department of Energy's (DOE) Brookhaven National Laboratory recently gathered around a workstation to watch as little ...
Paramount struggling to convert successful linear TV business into streaming, says Wolfe Research's Pete Supino
Peter Supino, Wolfe Research, weighs in on Paramount's renewed bid for Warner Bros. Discovery.
Smartphone App Successfully Supports First-Time Moms
By Dennis Thompson HealthDay ReporterTUESDAY, Feb. 17, 2026 (HealthDay News) — First-time moms are facing a potentially overwhelming amount of stress, caring for their new baby while also managing their own recovery from pregnancy and birth. But a new smartphone app can provide them much-needed ...
Struggling With Budgets? These Fast-Growth CEOs Share Their Capital-Saving Strategies That Actually Work
Saving money is key to growing your business. Here's how successful founders have pulled it off.
$26 million entertainment destination opens near UT-WY border
After a successful ribbon-cutting ceremony on Feb. 14, the Utah-Wyoming border is officially home to Horse Palace Gateway, a new entertainment destination off of Interstate-80.
How one man turned peanut butter and jelly into a successful business
Jeremiah Burns pursued a crazy idea. Just when it appeared a dream had died, a desperate prayer was answered.
Joe Heller: Cartoonist on news - Pam Bondi, Epstein, Olympic politics, Valentine's Day
Joe Heller was the editorial cartoonist for the Green Bay Press-Gazette in Green Bay, Wis., from 1985 until being laid off in July 2013. He still draws several cartoons a week and distributes them through his own syndicate. Through Heller Syndication, his cartoons regularly appear in more than 400 newspapers, making him the most successful...
KBC Group finalises acquisition of Business Lease Czech Republic and Slovakia
KBC Group NV, ČSOB Leasing Czech Republic, ČSOB Leasing Slovakia, and AutoBinck Group NV announce Today the successful closing of the agreement for ČSOB Leasing Czech Republic, ČSOB Leasing Slovakia to acquire 100% of the shares in Business Lease s.r.o. (“Business Lease Czech Republic”) and Business Lease Slovakia s.r.o. (“Business Lease Slovakia”). The transaction, originally announced on 23 October 2025, has received all necessary regulatory approvals, including from the Antimonopoly Office of
A bonobo’s pretend tea party is rewriting what we know about imagination
A bonobo named Kanzi surprised scientists by successfully playing along in pretend tea party experiments, tracking imaginary juice and grapes as if they were real. He consistently pointed to the correct locations of pretend items, while still choosing real food when given the option. The results suggest that imagination may not be exclusive to humans after all.
Winners of International Quantum Year science-journalism competition picked
Physics World and Physics Magazine announce successful pitches
BD Completes Combination of Biosciences & Diagnostic Solutions Business with Waters Corporation
FRANKLIN LAKES, N.J., Feb. 9, 2026 /PRNewswire/ -- BD (Becton, Dickinson and Company) (NYSE: BDX) today announced the successful completion of…...
Seaport Entertainment Group Completes Sale of 250 Water Street Development Project
NEW YORK–(BUSINESS WIRE)–Seaport Entertainment Group Inc. (NYSE: SEG) announced today it has successfully completed the sale of the mixed-use development... Read More
Cisco CEO: 'It's stupid' to interview internal candidates for promotions
Cisco CEO Chuck Robbins said there are three big traits the people "who are wildly successful" in tech all share.
La Verne teenager with autism turns his obsession with trash trucks into a small business
A 19-year-old entrepreneur with autism is successfully turning one of his passions into a profitable neighborhood business.
International science cooperation must go on, say research leaders
Science leaders in Europe and Canada say international cooperation must go on amid geopolitical turmoil. At the same time, Europe and like-minded countries should continue to enhance and diversify international partnerships, a Science|Business conference hears. Hugh Brady, president of Imperial College London, told delegates that Europe’s response to the current geopolitical climate should be to “diversify in terms of research partnerships and build resilience and scale into our own system.”A first priority should be for the EU to sort out the scope of the upcoming European Competitiveness Fund and ensure that, together with the next iteration of Horizon Europe, it can drive the development and scale up of new technologies. The EU and the countries associated to the Horizon Europe programme represent “the world's most successful research innovation ecosystem,” Brady said. In order to mitigate the negative effects of shifting geopolitics, the EU together with the UK, Switzerland, Canada, South Korea and others should talk about “building resilience” and address their own “regional needs,” he added. Responding to TrumpUnder Donald Trump’s leadership, the US government has slashed science budgets and shut down international research programmes. Nearly 8,000 grants at the National Institutes of Health and the National Science Foundation have been frozen or terminated. Courts have overturned most of these cancellations, but the disruption caused remains significant. While Europe may persuade a few thousand disgruntled scientists to move across the ocean to work on topics that have been de-funded in the US, it’s unclear what should happen next with transatlantic scientific cooperation more broadly.“Now is the time for us to show [US researchers] our support as much as we can,” Brady said.The European Research Council (ERC), the EU’s basic science funder, has seen a surge in applicants from the US. According its latest data, US-based researchers submitted 347 proposals to the last three big funding rounds, up from 158 in the previous set of calls. The European Commission has also launched a €22.5 million pilot call in 2025 for the Marie Skłodowska Curie Actions, the EU’s researcher training scheme. It plans to extend this support with a €51.25 million call in 2027 as part of the Choose Europe initiative, which is intended to make the continent a more attractive place to pursue a career in research. Related articlesData corner: US researchers are choosing EuropeEU-India deal highlights growing alignment on technology policyMeanwhile, in the private non-profit sector, the Volkswagen Foundation is experimenting with a new type of grant that would allow US researchers to split their time between the US and Germany. While these schemes are useful, Europe should not bet on an exodus of scientists from the US. “The idea that we might all see them flocking over to Europe is naïve and counterproductive,” said Maria Leptin, president of the ERC, also speaking at the Science|Business conference on February 5. “We need research in the US to be as healthy as possible. I really admire those who are staying there with a will to fight and an optimism that the world will turn into a better place again,” Leptin said. Preserving dataDespite political disruption, academics have found ways to continue cooperating and sharing research data. Leslie Weir, president of the International Federation of Library Associations and Institutions and Canada’s national librarian, said the US cuts have raised concerns about research data security, after ideologically sensitive databases were limited or deleted by the Trump administration. But international organisations teamed up to ensure that the data is not lost. “It's interesting to see that researchers and libraries across North America are collaborating to make sure that data at risk is duplicated elsewhere outside [the US],” Weir said.
Education, Entertainment Makes for Successful Second Annual Kids Day Game
Last Thursday, Valparaiso University and Valpo Athletics welcomed 500 fifth-graders from Valparaiso Community Schools to campus for the second annual women's basketball Kids Day game.
Black Castle Capital Partners Wins Best Venture Capital & Private Equity Business of the Year 2026
LONDON, Feb. 05, 2026 (GLOBE NEWSWIRE) -- London-based consultancy Black Castle Capital Partners has been honoured with the Global 100 – 2026 award for Best Venture Capital & Private Equity Business of the Year in the United Kingdom, recognising its boutique expertise in guiding companies through successful and efficient fundraising processes. Black Castle Capital Partners specialises in tailored introduction services across Private Equity, Venture Capital and Real Estate. The firm’s lean and ni
In forcing the Clintons to testify on Epstein, Comer sets a new precedent
The Republican chairman’s successful targeting of a former president who faces no charge of wrongdoing was the sort of tactic typical in an autocracy where leaders fear being jailed when they are out of power.
USU Uintah Basin Sponsors Successful Uintah Basin Science & Engineering Fair
More than 150 middle school students took part in the Uintah Basin Science and Engineering Fair, a regional event designed to encourage young learners to explore scientific discovery and engineering innovation.
Swanson Health Re-Platforms to Ordergroove and Shopify to Power World-Class Subscriber Experiences and Long-Term Customer Growth
The leading wellness brand replaces homegrown systems with innovative commerce and no-code subscription technology to deliver more personalized, engaging customer journeys.NEW YORK, Feb. 04, 2026 (GLOBE NEWSWIRE) -- Swanson Health, a global wellness brand known for premium quality vitamins and supplements and a long-standing reputation for customer service, today announced the successful launch of its eCommerce and subscription technology stack with Ordergroove, the leader in Relationship Commer
BETMGM FY 2025 BUSINESS UPDATE
Successful strategic execution delivered stronger than expected 2025 performance and EBITDA inflection JERSEY CITY, N.J., Feb. 4, 2026 /PRNewswire/ -- BetMGM LLC ("BetMGM"), a leading sports...
England sweep SL series in low-scoring thriller
England successfully defend a target of 129 to win by 12 runs against Sri Lanka in an enthralling contest, completing a 3-0 T20 series sweep.
Real Madrid captain posts strong message after Rayo Vallecano omission
Dani Carvajal is going through one of the most testing phases of his long and successful career at Real Madrid. The club captain was once again left without a single minute on the pitch during the re...
Media & Entertainment Group Of The Year: Gibson Dunn
Gibson Dunn & Crutcher LLP successfully defended OpenAI in the first defamation case against a chatbot, is representing Warner Bros. Television in a battle over the medical drama "The Pitt" and secured an appellate victory for Bob Dylan in a high-profile case, earning the firm a spot among the 2025 Law360 Media & Entertainment Groups of the Year.
Musk confirms SpaceX success in preventing Russian military from accessing stolen Starlink units
SpaceX CEO Elon Musk says his company successfully blocked Russia's "unauthorized" use of captured Starlink terminals in Ukraine on Sunday.
What does a successful season look like for Barcelona?
Today’s Question of the Day is about your expectations as a fan for the rest of the season.
Will Republicans break their losing streak on health care reform?
Republicans have repeatedly failed to successfully field an alternative to ObamaCare, but their new “Great Healthcare Plan” released in January offers some promising ideas, such as pric…
With boost from successful Burger Battle, DTSF details year ahead for downtown development, programming
The Downtown Burger Battle is bigger than ever this year – and Downtown Sioux Falls Inc. hopes that's a sign for the activity to come.
Owners of Twin Peaks restaurant file for bankruptcy
Officials with TWNP said in a news release that they will use the filings to strengthen their capital structure through reducing their debt to keep the corporation successful for years to come.
Is Wyoming hoops stuck in purgatory within modern college basketball?
Every season for a reasonably successful mid-major university begins in a similar fashion. They schedule a few in-state cupcakes as the season and home openers before, if they are lucky enough, participating in an ever-declining MTE tournament during the week of Thanksgiving. Throw in a dash of high-major money labeled as “buy games” to help […]
Iowa puts stringent defense up against Chad Baker-Mazara, USC
Southern California will try to close out a successful road swing on Wednesday in Iowa City, when the Trojans face an Iowa team seeking its third straight win.
COLUMN: Top 20 EIU sports moments of 2025
The year 2025 will be thought of as the year of an exhilarating half time show and a runaway joke that has left six or seven braincells remaining in my head. Closer to home, EIU sports experienced a successful year that included personal achievements, milestones, and Ohio Valley Conference championships. Now that the dust has settled on 2025, here are the top 20...