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Zelda 40th Anniversary Switch 2 Pro Controller restock tracker: we’re watching these retailers

🎮 Nintendo will release a Zelda 40th anniversary Switch 2 Pro Controller on October 29 💰 It costs $99.99, the same as other limited editions 📅 A restock could occur on launch day at Walmart and Best Buy 🚨 Our Zelda Switch 2 Pro Controller restock tracker @mattswider on X will send out an alert when stock appears Walmart: Zelda Pro Controller Best Buy: Zelda Pro Controller Amazon: Zelda Pro Controller Target: Zelda Pro Controller GameStop: Zelda Pro Controller Nintendo is releasing a special limited edition Nintendo Switch 2 Pro Controller to celebrate the 40th anniversary of The Legend of Zelda series. It releases on October 29, 2026, which is when we expect to see a long-awaited restock of the hard-to-find controller. 🚨 We’re tracking Zelda Switch 2 Pro Controller stock updates. If you’d like to know when more stock arrives, follow Matt Swider on X and turn on notifications. You can also become a free or paid subscriber to The Shortcut to help support our work. 🚨 The Switch 2 Pro Controller features the same striking gold and royal emerald color scheme of the Nintendo Switch 2 The Legend of Zelda 40th anniversary edition, and also includes a fun little easter egg on the back: an 8-Bit Link. 🚨 Want the Zelda 40th Anniversary Switch 2 Pro Controller? Drop your email for restock alerts before it sells out. ⤵️ Subscribe This is the same Nintendo Switch 2 Pro Controller we’re used to, aside from the intricate design, but it means you’ll have to pay more as a result. It costs $99.99 instead of the standard $89.99. However, the Pro Controller is the easiest way to play the best Switch 2 games in TV mode. If you’ve been searching for a Zelda 40th Anniversary Switch 2 Pro Controller restock, here’s everything you need to know. Zelda 40th anniversary Switch 2 Pro Controller should restock at these retailers We’ve seen retailers such as Walmart and Best Buy restock items on release day, even when pre-orders have sold out. It’s likely that the Zelda Switch 2 Pro Controller will be up for grabs on October 29, 2026, when the controller and console launches. Demand will be high, and stock could sell out fast. However, we’ll be keeping a close eye on every major retailer, including Target, Amazon, GameStop, and the Nintendo Store and will alert our followers as soon as stock goes live. Why you can trust our Zelda Switch 2 Pro Controller restock tracker We’ve already helped over 400,000 people buy a PS5 when it was in and out of stock during Covid, and we’ve helped our subscribers continue to secure hard-to-find items. The Shortcut followers were some of the first to secure the Switch 2 when it went on sale, and we’ve also helped countless others snag limited edition consoles like the PS5 30th anniversary edition. The Shortcut and Matt Swider on X offer exclusive Zelda 40th anniversary Switch 2 Pro Controller restock updates with up-to-the-second US store inventory checks at the biggest retailers. You’ll receive an instant notification on X (if set to on) as soon as new stock arrives. Up next: Call of Duty: Modern Warfare 4 review roundup: ‘a strong return to form’ Subscribe Adam Vjestica is The Shortcut’s Senior Editor. Formerly TechRadar’s Gaming Hardware Editor, Adam has also worked at Nintendo of Europe as a Content Marketing Editor, where he helped launch the Nintendo Switch. He also runs a retro gaming YouTube channel called Game on, boy! Follow him on X @ItsMrProducts.

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Oct 26 • 12:28 PM EDT • Technology • theshortcut.com
HKSTP Partners with Leading Science and Technology Company Merck to Open a New Chapter in I&T Collaboration

EQS Newswire / 26/10/2026 / 17:15 CET/CEST New Merck Hong Kong Centre to Connect Global Expertise with Local Innovators and Accelerate R&D Commercialisation HONG KONG SAR – Media OutReach Newswire – 26 October 2026 – Hong Kong Science and Technology Parks Corporation (HKSTP) and Merck, a leading…

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Oct 26 • 12:15 PM EDT • Science • tradingview.com
I tested the new Amazon Kindle for a week. Here’s why it’s the one you probably want

Our tech writer has long recommended the Kindle Paperwhite, but he’s starting to think the regular Kindle might be the best option for the new lineup.

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Oct 26 • 12:03 PM EDT • Technology • cnn.com
Salesforce vs. International Business Machines: Which Technology Stock Is a Better Buy in 2026?

Salesforce trades at a lower forward multiple, while IBM offers cheaper valuation on sales, but their balance sheets tell starkly different stories.

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Oct 26 • 11:50 AM EDT • Business • finance.yahoo.com
ChatGPT Keeps Telling People 404 Media Can Solve Their Tech Support Problems

Because big tech doesn't do customer service, we are being inundated with AI-generated emails begging us for help.

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Oct 26 • 11:49 AM EDT • Technology • 404media.co
Bon Secours Mercy Health to acquire majority stake in Surgery Partners in $5.7B deal

Bon Secours Mercy Health is acquiring a majority share in healthcare services company Surgery Partners in a take-private deal valuing the acquiree at $5.7 billion, the organizations announced Monda | The pending deal values the short-stay surgical platform at $5.7 billion, and is the latest example of large health systems' push to build out their ambulatory networks.

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Oct 26 • 11:37 AM EDT • Health • fiercehealthcare.com
HHS Finalizes HTI-5 Deregulatory Rule to Encourage Innovation and Reduce Health IT Certification Program Compliance Costs

HHS released the Health Data, Technology, and Interoperability: ONC Deregulatory Actions to Unleash Prosperity (HTI-5) Final Rule.

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Oct 26 • 11:30 AM EDT • Health • hhs.gov
A new Antarctic science season begins for 2026/27

From investigations with cutting-edge technologies, to building on decades of data collection – this season’s science will help us understand how this frozen landscape is changing.

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Oct 26 • 11:27 AM EDT • Science • bas.ac.uk
📈 Monday data: The bottleneck isn’t intelligence

In the AI Investment Brief today: CapEx updates and lease commitment breakdowns Anthropic co-founder Jack Clark recently said in a speech at the IMF that the singularity has begun: For many years, researchers and science fiction authors have forecast a future in which AI systems drastically increase the pace of overall scientific and technical progress, making things move so quickly that it is hard for humans to keep up. They call this the singularity. I believe that this year we have gained convincing evidence that it has now begun. This follows Anthropic’s claim that in August, 26% of its AI R&D was led by Claude, with a human supervising its work. In October, OpenAI posted 719 math manuscripts1 made by its internal model. Math and coding are two fields where a research loop can close without leaving the desk. But can the loop close in the rest of science? Subscribe The loop is real The idea is not new. Mathematician Irving John Good, who had worked with Alan Turing at Bletchley Park, argued that a machine smarter than us “could design even better machines; there would then unquestionably be an ‘intelligence explosion,’ and the intelligence of man would be left far behind.” The Gödel machine, a self-improving computer that can rewrite its own code better than its prior, was first proposed in 2003. In 2025, researchers at Sakana AI and the University of British Columbia set out to show that this was possible. Their agents iteratively improved their own code through a feedback loop, resulting in gains of 30 pp on SWE-bench and more than 15 pp on Polyglot, testing coding skills beyond Python. The idea has since been tested in other labs. A Gemini-powered agent called AlphaEvolve found a faster matrix multiplication kernel used for training Gemini, speeding up the kernel by 23% and cutting Gemini’s training time by 1%. In China, MiniMax reported that its M2.7 model worked on improving its own agent’s harness, skills, sampling and memory. Over 100 rounds of rewriting led to a 30% gain, per its internal evaluations. In each case, what was being rewritten was not the model itself but everything around it. Is it better than human work? In September this year, in what seemed like a milestone, an AI-built agent proved as good at improving other AI agents as a human-built one. It did that in what appeared to be half the steps. But the result was inconclusive: the differences between runs were greater than the difference between the AI- and human-built agent results. Nonetheless, this is increasing the chatter around recursive self-improvement (RSI) in AI. Google’s Sundar Pichai said that “you have RSI loops along with AI researchers in various aspects of model development.” Sakana AI published a paper on RSI through multi-agent collaboration, finding that after two cycles its system scored 1.2–1.6x better per output token than the base model across four research benchmarks. Ramez Naam challenges that view. He splits AI self-improvement into five overlapping types. The first four describe how autonomous the AI is; so far, only types 1 and 2 have been observed. The fifth type describes accelerating returns, and he notes that greater autonomy doesn’t guarantee a takeoff scenario. Instead, each round of self-improvement would need to deliver at least as much as the last. The results from Sakana, AlphaEvolve and MiniMax above might look like type 3 or type 4 autonomy. But in each case, the AI wasn’t updating its own weights directly, only the ancillary parts — the harness, the memory. And where Claude leads its own R&D, for now a human still supervises.

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Oct 26 • 11:25 AM EDT • Science • exponentialview.co
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New Twin Cities Lab Changing The Landscape Of Health

Human Powered Health is strengthening its mission to help motivated people improve their health and longevity with the opening of an expansive human performance lab. Featuring an array of physiological assessments, longevity and athletic performance services, the state-of-the-art technology and health optimization services once reserved for elite athletes are now accessible and available for everyone.

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Oct 26 • 11:00 AM EDT • Health • finance.yahoo.com
What smart people are saying about Anthropic's IPO paperwork

Investors and tech onlookers react to Anthropic's IPO, from its soaring revenue and massive compute commitments to questions about its operations.

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Oct 26 • 10:56 AM EDT • Business • businessinsider.com
Port Tampa Bay channel deepening advances with engineering work

Soil testing will guide design of the port’s generational infrastructure project, intended to lower transportation costs and improve the flow of goods throughout West Central Florida.

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Oct 26 • 10:46 AM EDT • Business • businessobserverfl.com
Seeing isn’t believing when deepfakes pervade politics

AI-generated videos and images are becoming inescapable and threaten to turbocharge disinformation in Georgia elections, and while the technology is new, the tactic is not.

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Oct 26 • 10:39 AM EDT • Politics • times-herald.com
Apple unveils new iPad mini with OLED display and faster A20 Pro chip

The new iPad mini features a thinner and lighter design than its predecessor.

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Oct 26 • 10:25 AM EDT • Technology • techcrunch.com
NASA's Swift Observatory Ends Its Science Mission

NASA's Swift observatory made its last observation on Oct. 20 after 22 years, 2,000-plus gamma-ray bursts and about 7,000 papers.

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Oct 26 • 10:18 AM EDT • Science • technology.org
Europe takes cancer science into ­immunology

Inspired by technology and ­insights gleaned from cancer research, Europe is leading the quest for a new generation of therapies in immunology and inflammation. Immunotherapy has revolutionised cancer therapy and ­become standard of care in many areas of ­oncology but it has also begun to change outcomes in inflammatory and autoimmune diseases.

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Oct 26 • 10:06 AM EDT • Science • european-biotechnology.com
University of Detroit Mercy lands $7.75M defense grant to grow cybersecurity, AI workforce pipeline​

The funds are to help address workforce shortages in advanced technological disciplines essential to modern military operations and applicable to civilian life.

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Oct 26 • 10:01 AM EDT • Business • crainsdetroit.com
Revolut Expands UK Banking Business With Personal Loans

FinTech Revolut debuted its first credit product since becoming a licensed United Kingdom bank, according to a Monday (Oct. 26) press release provided to

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Oct 26 • 9:46 AM EDT • Business • pymnts.com
These are Chicago’s Most Innovative Companies for 2026

Crain's exclusive ranking reveals the Chicago-area companies developing patented innovations in technology, healthcare, manufacturing and more.

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Oct 26 • 9:45 AM EDT • Business • chicagobusiness.com
Meta Plans To Raise Up To $95 Billion In Equity To Power AI

Meta stock was lower premarket after the tech giant announced plans to raise $95 billion in equity.

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Oct 26 • 9:17 AM EDT • Business • investors.com
Google Beam Is Being Deployed At 20 USO Locations

This is the company's impressive 3D video conferencing tech.

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Oct 26 • 9:00 AM EDT • Technology • engadget.com
The State of Politics: How The Tax Break for Data Centers Was Passed

$1.9 billion annual handout to massive tech companies quietly put into 2023-25 budget.

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Oct 26 • 8:17 AM EDT • Politics • urbanmilwaukee.com
Rice engineering students become first university group inside Apple’s new Advanced Manufacturing Center

Rice University materials science and nanoengineering students gained hands-on experience in AI server production and surface-mount technology during an exclusive tour of Apple’s new Advanced Manufacturing Center in Houston.

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Oct 26 • 8:00 AM EDT • Science • news.rice.edu
Property owners invest in resilience, but insurers slow to recognize efforts

Commercial property owners are investing in resilience measures, such as roof upgrades, automatic sprinklers and water-monitoring technologies, but insurer recognition of those efforts is still…

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Oct 26 • 7:59 AM EDT • Business • businessinsurance.com
CleanYourTV 3.0 Lets You Remove Ads And Bloatware From Android And Google TVs, Now Supports 300 Models

CleanYourTV 3.0 enhances smart TV experience with ad-blocking, compatibility for 300 models, and an easy phone setup, gaining 37,000+ GitHub stars.

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Oct 26 • 7:42 AM EDT • Technology • wccftech.com
New Allied Health Concentration Fuses Healthcare Delivery with Emerging Technologies

The new Digital Health and Technology concentration gives UConn students firsthand experience with the tools transforming modern healthcare and build skills ...

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Oct 26 • 7:20 AM EDT • Health • today.uconn.edu
From impulse purchase to pocket studio: The M-Vave FM-1

M-Vave's cheap FM-1 pocket synth has exploded as a community firmware playground.

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Oct 26 • 7:00 AM EDT • Technology • arstechnica.com
Israel's tech scene warms to crypto payments

From blockchain expertise to evolving regulations, Israel’s tech ecosystem is helping normalize crypto payments, including for online poker and digital entertainment.

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Oct 26 • 6:59 AM EDT • Entertainment • jpost.com
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Exclusive-US Political Candidates Tailor Messages for AI Models Used by Voters

By Mike Stone WASHINGTON, Oct 26 (Reuters) - US political candidates have been engineering their campaign messages to appeal to the AI chatbots ⁠that ⁠more voters have been using to answer questions about issues, and ⁠documents seen by Reuters have revealed some of their strategies. One Powerpoint ...

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Oct 26 • 6:04 AM EDT • Politics • usnews.com
Exclusive: Health tech PE megadeals surge as deal volume drops

The average health care buyout size jumped to $3.4 billion in the first half of 2026.

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Oct 26 • 6:00 AM EDT • Health • axios.com
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Shake-ups and layoffs reveal a culture clash inside Netflix

Increasingly, tensions have flared between the L.A.-based executives dedicated to movies and TV shows and its engineers and technicians in Silicon Valley over how best to expand the business and promote content on Netflix.

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Oct 26 • 6:00 AM EDT • Entertainment • latimes.com
Apple stock rally, Nvidia sell-off could reshuffle most valuable company

Nvidia remains an AI powerhouse, but Apple's cash-rich consumer business offers investors a different kind of Big Tech bet.

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Oct 26 • 5:50 AM EDT • Business • businessinsider.com
Micro1 invests $1B to license data for AI model development

Micro1 is pledging $1 billion to gobble up more companies' internal data for licensing to AI model developers, part of a new wave for the tech.

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Oct 26 • 5:00 AM EDT • Business • businessinsider.com
New Orleans-based biotech company lured to SC as first for MUSC lab

The company name was deliberately chosen from West African lore: Obatala, the god who shaped the human body. And the New Orleans biotech firm is determined to see that their human-based research lab m...

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Oct 26 • 5:00 AM EDT • Science • yahoo.com
Hollywood's uncanny evolution of evil billionaire tech bros

If you really want to understand the extent to which everyone thinks Silicon Valley is so uncanny these days, watch "Cupertino."

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Oct 26 • 4:17 AM EDT • Business • businessinsider.com
From bright ideas to real businesses: women entrepreneurs make their mark in Shenzhen

At the SC WIN Now & Next Challenge, women-led businesses demonstrated how innovation, technology and purpose can come together to drive growth

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Oct 26 • 4:01 AM EDT • Business • scmp.com
Goldwind Science & Technology: 9M26 profit reached RMB2.9 billion as WTG sales rose and backlog hit 57.0 GW

9M26 revenue was RMB52.0 billion and attributable net profit RMB2.9 billion. WTG sales rose 3.02% YoY, while total backlog reached 57.0 GW; operating cash flow was negative RMB30 million.Original document: Goldwind Science & Technology Co. Ltd. Class A [002202] Slides Release — Oct. 26 2026This is…

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Oct 26 • 2:26 AM EDT • Science • tradingview.com
How Functional Foods Deliver Bioactive Compounds and Support Gut Health

Functional foods use delivery systems such as encapsulation, lipid carriers, and hydrogels to protect bioactive ingredients and control their release during digestion. These technologies may improve nutrient availability, but human studies are needed to establish their health benefits and long-term safety.

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Oct 26 • 2:21 AM EDT • Health • news-medical.net
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Fabarta Unveils Major Upgrade to Its AI for Science Platform, Named Among Inaugural "Hong Kong Top Talent Ecosystem Partners" Ahead of Hong Kong FinTech Week

PR Newswire | ​Powered by the upgraded RSI engine, the platform unifi

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Oct 26 • 2:00 AM EDT • Science • macaubusiness.com
Marco Rubio’s Greek Panegyric / Celebration: Political Theory and Praxis

Prologue Translating the ideals of Greek history, politics, democracy, theater, athletics, the Delphi peace vision, philosophy, science, technology,

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Oct 26 • 1:48 AM EDT • Politics • counterpunch.org
E-Z Health helps seniors find relief with dedicated healthcare phone guides

Closing the technology gap, a Medicare-covered program is helping seniors find local resources and save money on essential services. FOX 10's Annalisa Pardo reports.

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Oct 26 • 12:39 AM EDT • Health • fox10phoenix.com
China's Rise in Science as a Source of Strategic Power

China is on course to lead the world in research and development, a shift with direct consequences for technological competition and the balance of global power. That is the conclusion of a news feature by Xiaoying You in Nature, published on October 14, 2026. The scale of the change is striking. In 1978, researchers in […]

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Oct 26 • 12:09 AM EDT • Science • sldinfo.com
Nu Holdings (NU) Faces Political And Leadership Questions, Does It Look Fairly Valued?

Election shock and leadership change put Nu Holdings in focus Nu Holdings (NYSE:NU) is under fresh scrutiny after a Brazilian election result sparked a double digit overnight drop in the stock, just as the fintech disclosed a pending chief technology officer departure. Over the past month, Nu Holdings has seen an 11.55% share price return and a 4.12% gain over seven days, even though the year to date share price return is down 10.93% and the one year total shareholder return has declined...

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Oct 25 • 10:07 PM EDT • Politics • finance.yahoo.com
Google appoints Anne Claire Grammer to Gemini mental health role | ETIH EdTech News

Google has appointed clinical psychologist Anne Claire Grammer as Senior Clinical Specialist, Mental Health, working on the accuracy and safety of Gemini's mental health responses. ETIH edtech news covers her appointment, including previous AI product safety work at BetterHelp and her academic role

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Oct 25 • 9:15 PM EDT • Health • edtechinnovationhub.com
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The best apps for tracking your reading and discovering new books

There are many apps that are designed to help you track your reading and discover new books, so we compiled a list of some of the best ones.

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Oct 25 • 9:10 PM EDT • Technology • techcrunch.com
Tiny magnetic vortices could help computers work more like your brain

Scientists have filmed tiny magnetic vortices called skyrmions melting out of an organized lattice for the first time, revealing new ways to manipulate these unusual structures. The breakthrough could help make brain-like computers a reality, potentially enabling dramatically smaller and more energy-efficient technology.

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Oct 25 • 8:00 PM EDT • Science • sciencedaily.com
Innovative food processing technique boosts Nebraska companies, educational outreach

Leadership and strategic visioning by Mary-Grace Danao, research associate professor in the Department of Food Science and Technology and the Department of Biological Systems Engineering, has helped position the University of Nebraska–Lincoln at the forefront of high pressure processing-focused food safety research in partnership with private industry.

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Oct 25 • 8:00 PM EDT • Science • news.unl.edu
Young Scientists Congress: New technologies take centerstage at science exhibition in Wenzhou

The World Young Scientists Congress has opened in Wenzhou, east China's Zhejiang Province. More than 800 scientists and entrepreneurs from over 60 countries and regions are attending the event which includes an exhibition of the latest technologies. We spoke with some of the visitors to the event.

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Oct 25 • 8:00 PM EDT • Science • news.cgtn.com
Over 300 students learn science and technology at CCSD Family STEM Day

Over 300 students learned about science and technology industries at the Clark County School District Magnet Schools Family STEM Day on Saturday.STEM Day as he

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Oct 25 • 6:00 PM EDT • Science • news3lv.com
Texas Tech Takes 9-Spot Coaches Poll Hit After Cincinnati Meltdown

Texas Tech falls nine spots to No. 14 in the US LBM Coaches Poll after losing at Cincinnati, putting Joey McGuire and the Red Raiders under pressure to rebound.

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Oct 25 • 6:00 PM EDT • Sports • sports.yahoo.com
Clemson’s Loss to Virginia Tech Puts the Program in Flux

Clemson’s loss to Virginia Tech puts the program in flux heading into November. The Tigers now find themselves on the outside looking in on the ACC Championship race after being defeated 20-16 by the Hokies. Dabo Swinney’s team played well in many spots, especially in the third quarter. The complementary football Clemson displayed to start the …

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Oct 25 • 5:05 PM EDT • Sports • sports.yahoo.com
Tampa technical institute expands bilingual health care career training

Aguilas International Technical Institute has opened a larger Tampa facility, expanding bilingual career training as health care demand grows locally.

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Oct 25 • 3:57 PM EDT • Health • baynews9.com
Big Las Vegas show closures mark a transitional time for Strip entertainment

The culture of Las Vegas is inextricably linked to the artists and technicians behind the Strip’s vibrant live entertainment industry, so any time a show closes

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Oct 25 • 3:30 PM EDT • Entertainment • cdcgaming.com
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Scientists Develop a Clever New Way To Kill Cancer Cells From the Inside

Scientists have developed an experimental strategy that exploits a chemical byproduct of cancer cells to produce anticancer drugs directly inside them. Scientists in Japan have developed an experimental method that uses a chemical produced by cancer cells to manufacture anticancer drugs directly inside them. The approach relies on carbon monoxide, a toxic gas that certain

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Oct 25 • 1:45 PM EDT • Science • scitechdaily.com
Google's privacy policy now has a loophole for using your Gmail and Photos data in ads

The change sits in Google's updated privacy policy, which took effect on October 16 and was first spotted by Android Authority. The policy has long said, "We...

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Oct 25 • 1:33 PM EDT • Technology • techspot.com
Elon Musk’s Grok Releases First AI-Generated “Odyssey” Episode

Months after Elon Musk promised that Grok Imagine would make an entirely AI “Odyssey” film, the tech mogul has partially followed through.

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Oct 25 • 1:22 PM EDT • Technology • variety.com
Cattle Science Gets a $19.5 Million Upgrade as West Texas A and M Plans High-Tech Research Complex

West Texas A&M is building a $19.5M cattle research complex featuring AI technology, veterinary research and commercial-scale feedlot studies.

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Oct 25 • 12:45 PM EDT • Science • myvetcandy.com
Bloomington business continues to blossom

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Oct 25 • 12:11 PM EDT • Business • insideindianabusiness.com
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Apollo: AI has delivered 'zero financial payoff' to corporate America

Only tech companies are seeing growth from the AI boom, Apollo Global Management said.

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Oct 25 • 12:02 PM EDT • Business • businessinsider.com
ESMO: Roche touts ‘convincing’ phase 3 KRAS data after win over rivals

Roche has shed more light on its investigational KRAS G12C inhibitor's phase 3 victory over Amgen’s Lumakras and Bristol Myers Squibb’s Krazati. The open-label Krascendo 1 trial enrolled 338 people with previously treated KRAS G12C-mutated non-small cell lung cancer (NSCLC). Patients who had already received a KRAS G12C inhibitor or pan-KRAS/RAS inhibitor were excluded from the trial. Participants received either divarasib once daily, Lumakras once daily or Krazati twice daily. Roche announced back in July that divarasib had demonstrated statistically significant improvements in progression-free survival (PFS) and overall survival (OS), meeting the trial’s primary and key secondary endpoints. But the Swiss pharma had been holding back the detailed data until now. At the European Society for Medical Oncology (ESMO) Congress in Madrid, Roche revealed that median OS for the 167 patients who received divarasib was 17.7 months, compared to 12 months for the 171 patients who received Lumakras or Krazati. The benefit was similarly clear when it came to median PFS, which stood at 9.8 months versus 5.7 months, respectively. A total of 44% of patients receiving divarasib were alive without disease progression at one year, compared to 24% of the control group, according to Roche’s presentation. It was a similar story for the objective response rate, which came in at 58% for divarasib versus 32% for the control group, while median duration of response was 11.9 months versus 6.9 months. Stefan Frings, M.D., Ph.D., deputy chief medical officer at Roche Pharma, told Fierce that the data made for a “very comprehensive, strong package, which should be convincing to health authorities.” “It’s an important advance for patients with lung cancer,” Frings said in an interview at a Madrid hotel during the conference. “It's a second-line setting, and patients who receive divarasib benefit compared to the current first-generation KRAS G12C inhibitors by having far longer overall survival,” he continued. “They live longer. They have better progression-free survival, better response rates, and with a safety profile which is—if [anything]—even better,” he said. According to Roche, 4.8% of patients receiving divarasib discontinued treatment due to treatment-related adverse events, compared to 11.7% in the control group. Serious treatment-related adverse events were also less common with divarasib, at 7.8% versus 15.2%. Roche’s confidence in divarasib had been building even before this phase 3 success. The candidate had already shown better potency and selectivity than the incumbent KRAS G12C inhibitors Krazati and Lumakras in preclinical tests. After cross-trial comparisons suggested that the edge translated into better clinical outcomes, Roche axed a study comparing divarasib to the chemotherapy docetaxel and went toe-to-toe with Lumakras and Krazati. “We designed the drug on purpose with higher potency and better selectivity,” Frings explained. “So, based on preclinical models, we clearly knew it would be superior to the first generation.” “It’s honestly not so frequent that pharma companies go head-to-head,” he added. “But if you want to make a point, if you want to convince payers, prescribers and patients … then a head-to-head win is rather rewarding.” While Amgen and BMS reached the regulatory finish line first for KRAS G12C-mutated, locally advanced or metastatic NSCLC in 2021 and 2022, respectively, they have struggled to capitalize on their head start. Krazati brought in $55 million for BMS in the second quarter, while Lumakras delivered $111 million to Amgen. For its part, Roche is aiming for peak divarasib sales of 1 billion to 2 billion Swiss francs ($1.2 billion to $2.5 billion), according to Frings. The Big Pharma is currently recruiting patients into a phase 3 trial comparing divarasib plus Keytruda against Keytruda plus chemotherapy in previously untreated advanced or metastatic nonsquamous KRAS G12C-mutated NSCLC. Roche has previously suggested that sales in metastatic disease would account for most of the forecast. Frings was tight-lipped on the exact timeline for a regulatory filing but said the Swiss pharma is “certainly keen to get this to as many patients as possible around the world.” Roche has more RAS drugs coming up behind divarasib. The pharma has already launched phase 1 trials of a pan-RAS inhibitor called RG6505 and a KRAS G12D inhibitor dubbed RG6620 in solid tumors. Roche’s partner Chugai Pharmaceutical is also testing a pan-KRAS inhibitor called AUBE00. Roche has made a “deliberate effort” to test a range of RAS drugs, Frings said. “If you have many rare mutations and you are scrambling to find sufficient patients, a pan-RAS inhibitor makes a lot of sense,” he explained.

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Oct 25 • 11:30 AM EDT • Health • fiercebiotech.com
Texas Tech Leads 'Bad' Week 8 for Big 12 Unbeatens

The Red Raiders’ playoff dreams hit a wall in Cincinnati as sloppy play and missed opportunities ended their unbeaten run. The Big 12 race is now more open than ever after surprising finishes elsewhere.

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Oct 25 • 11:28 AM EDT • Sports • sports.yahoo.com
Google's next TV gadget may do much more than stream

A reported hardware overhaul could bring Gemini further into the living room.

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Oct 25 • 11:17 AM EDT • Technology • thestreet.com
Their friend died of cervical cancer in 2020. Now, they advocate for women’s health in N.S.

Following the death of their close friend from cervical cancer in 2020, two women in Nova Scotia were left wondering how things might have been different had she been diagnosed earlier. Six years later, they have raised over $4 million to improve technology and infrastructure for women's health.

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Oct 25 • 11:05 AM EDT • Health • cbc.ca
GeForce Unlocked: Modders Boost RTX 20, RTX 30, and RTX 40 Compute Performance by Up to 2x

NVIDIA's GeForce RTX 30-series and RTX 40-series graphics cards are based on the same dies as their professional-grade GPUs. This means the compute potential of consumer-oriented RTX GPUs is restricted by NVIDIA's firmware stack, but modders have managed to unlock the instruction issuing rate...

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Oct 25 • 10:43 AM EDT • Technology • techpowerup.com
Investment driving growth at NWS Crane

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Oct 25 • 9:53 AM EDT • Business • insideindianabusiness.com
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Science Snapshots: October 25, 2026

Three key science updates in one minute: Starry Night’s dawn matched to Jul 22, 1889; cold boosts lifespan via BH2/BH4; cluster similar-buildings cools cities.

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Oct 25 • 9:40 AM EDT • Science • thehindu.com
Clemson HC Dabo Swinney Waving White Flag on Season

Following a humbling loss to Virginia Tech, Dabo Swinney is recalibrating expectations as the Tigers abandon playoff dreams and fight to salvage a disappointing, sub-par season.

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Oct 25 • 9:36 AM EDT • Sports • sports.yahoo.com
Physician Mental Health and Health System Privacy: Why Doctors Avoid Their Own EHR

In most organizations the default access model was built for patient care, not for protecting colleagues. A nurse on another unit, a resident who rotated with them, a department administrator: any of them may technically be able to open the record, even when policy says they should not.

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Oct 25 • 9:21 AM EDT • Health • medcitynews.com
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Can GE Vernova's Gas Turbines Make Up for a Collapsing Wind Business?

It's a red flag investors would rather not see waving, but most of them may not have put this shift in its proper perspective.

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Oct 25 • 8:30 AM EDT • Business • fool.com
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6 Tech Brands Owned By Best Buy

Best Buy owns several tech brands, including Insignia, Rocketfish, and Best Buy Essentials, that offer competitive performance and value.

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Oct 25 • 8:15 AM EDT • Technology • slashgear.com
Scientists overcome a hidden obstacle to more powerful quantum computers

Scientists have discovered a way to operate multiple silicon qubits simultaneously with remarkable accuracy, overcoming a major challenge in scaling up quantum computers. Their new technique maintained accuracy of approximately 99.9% even when all five qubits were running at once, opening the door to larger and more powerful quantum processors.

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Oct 25 • 8:00 AM EDT • Science • sciencedaily.com
Antarctica’s “Doomsday Glacier” Could Raise Sea Levels Twice As Much as Scientists Feared

Even without further warming, Thwaites Glacier could contribute twice as much to sea level rise by 2100 as previously estimated, according to a revised ice sheet model. Thwaites Glacier in West Antarctica has been retreating and thinning rapidly, while satellites show substantial acceleration in its ice flow. Traditional ice sheet models have depicted slower movement,

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Oct 25 • 6:32 AM EDT • Science • scitechdaily.com
Misery Index: Texas Tech's big money and bigger talk can't save it from embarrassing loss
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Oct 25 • 12:46 AM EDT • Sports • sports.yahoo.com
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Clemson HC Dabo Swinney Puts Coach on Notice, Offense 'Disturbing'

After a deflating loss to Virginia Tech, Swinney confronts roster gaps and coaching failures as the Tigers' playoff hopes vanish and the offense faces a critical crossroads.

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Oct 25 • 12:23 AM EDT • Sports • sports.yahoo.com
'The church has ceded the commanding heights of science': New Trinity…

Huntsville could soon be home to a groundbreaking Christian liberal arts college focused on preparing students for careers in Science, Technology,…

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Oct 24 • 8:00 PM EDT • Science • 1819news.com
'The church has ceded the commanding heights of science': New…

Huntsville could soon be home to a groundbreaking Christian liberal arts college focused on preparing students for careers in Science, Technology,…

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Oct 24 • 8:00 PM EDT • Science • 1819news.com
(BPRW) MedHaul Wins Prize in AI Health Innovation Competition

(Black PR Wire) Memphis, TN — MedHaul, a digital health company whose technology platform allows healthcare providers to easily and quickly match their patients with appropriate medical transportation, has won WellWithAll&rs...

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Oct 24 • 8:00 PM EDT • Health • blackprwire.com
Pfizer And 2 Other AI Healthcare Stocks To Watch

Warning signs around heavily indebted AI infrastructure firms have grown louder after analysts raised the risk of a tech debt spiral, with some newer players struggling to finance data centers and high-end chips. That strain shifts attention toward more grounded uses of AI that address urgent problems such as healthcare. Investors seeking substance over hype may find this article useful. It profiles three AI powered healthcare stocks from our screener. The three stocks covered below are a...

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Oct 24 • 6:09 PM EDT • Health • finance.yahoo.com
Scientists Studied 865 Humpback Whales and Found They Grow Faster Than Expected

Despite decades of environmental change and population recovery, eastern Australian humpback whales appear to have maintained their historical adult size. Eastern Australian humpback whales grow at an extraordinary pace, reaching approximately 10.9 meters (35.8 feet) in length by age five. By six or seven years old, they have already attained about 90 percent of their

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Oct 24 • 5:48 PM EDT • Science • scitechdaily.com
Rep. Lisa McClain: Rural Michiganians deserve first-class healthcare

No law can make Michigan smaller. But we can make healthcare more accessible in rural communities and use modern technologies to make those miles matter less.

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Oct 24 • 4:06 PM EDT • Health • detroitnews.com
Oklo Is Down 61% This Year Despite a Real Technical Milestone. Here's the Disconnect Between the Stock and the Science.

What's going on with Oklo?

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Oct 24 • 3:47 PM EDT • Science • finance.yahoo.com
Google gives Fitbit a major health upgrade with one catch

Some of its most advanced insights require a $9.99 subscription.

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Oct 24 • 3:33 PM EDT • Technology • thestreet.com
Oklo Is Down 61% This Year Despite a Real Technical Milestone. Here's the Disconnect Between the Stock and the Science.

What's going on with Oklo?

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Oct 24 • 3:27 PM EDT • Science • fool.com
Honeywell Technologies CEO Says Business Is Growing Faster Than Expected

Honeywell International Inc. stock traded lower in premarket trading Thursday after the company reported mixed third-quarter results, with adjusted earnings beating Wall Street expectations while revenue fell short of estimates. Earnings Beat Estimates, Revenue Falls Short The company, which uses...

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Oct 24 • 2:30 PM EDT • Business • finance.yahoo.com
Global Leading Robot Dog Dinosaur Manufacturer Hidinosaurs: Redefining Smart Entertainment at CAAPA

The location-based entertainment industry is entering a new era driven by Smart Entertainment, where interactive technology and immersive storytelling define

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Oct 24 • 1:15 PM EDT • Entertainment • einnews.com
LANL’s Bradbury Science Museum Expands Annual High-Tech Halloween Event To Adult Crowd

Bradbury Science Museum Director Patrick Moore welcomes Halloween-goers. Courtesy/BSM

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Oct 24 • 11:25 AM EDT • Science • ladailypost.com
These clever apps show off the iPhone Duo's potential

From retro cassette players and virtual notebooks to flight trackers and even a digital toaster, developers are finding creative ways to take advantage of Apple's first foldable iPhone.

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Oct 24 • 11:00 AM EDT • Technology • techcrunch.com
Clemson's Road to an Improbable CFP Appearance Starts Now

The Clemson Tigers could start something special against Virginia Tech on Saturday.

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Oct 24 • 10:56 AM EDT • Sports • sports.yahoo.com
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NVIDIA GeForce RTX 30 GPUs Get Up To 2X Faster AI Compute Performance With New GPU Unlock Mod, Real-World Gains Of Up To 60%

NVIDIA's GPU Unlock boosts RTX 30 Series Tensor Core performance, showing up to 94% improvements in compute tasks without driver modifications.

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Oct 24 • 10:52 AM EDT • Technology • wccftech.com
These tiny snakes roll four times faster than they slither

Tiny snakes in Southeast Asia have mastered an extraordinary escape technique: rolling across the ground at speeds up to four times faster than ordinary slithering. Scientists discovered that dwarf reedsnakes accomplish this feat through precisely coordinated body movements that allow their bodies to rotate while their heads remain remarkably stable.

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Oct 24 • 8:00 AM EDT • Science • sciencedaily.com
Laika has spent 20 years building up to Wildwood

How the stop-motion animation studio blends traditional techniques with modern tech.

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Oct 24 • 8:00 AM EDT • Entertainment • theverge.com
Scientists propose a way to detect dangerous “mirror life” before it exists

Scientists have proposed a way to detect “mirror life,” a hypothetical form of life that could pose serious risks to humans, animals, and ecosystems if artificially created. Using special fluorescent molecules and a type of polarized light also used in 3D movie technology, researchers believe they could distinguish ordinary organisms from their mirror-image counterparts.

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Oct 24 • 8:00 AM EDT • Science • sciencedaily.com
Iran, Kyrgyzstan seek to expand science and technology cooperation

TEHRAN – Iranian and Kyrgyz officials have called for expanded cooperation in science and technology during a meeting on the sidelines of the 5th World Creative Economy Conference in Jakarta.

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Oct 24 • 7:28 AM EDT • Science • tehrantimes.com
Tech guru Paul Wick says 'doom and gloom' over AI is overblown

Paul Wick of Seligman Investments said the tech industry seems "healthier" today than during the Internet bubble, but flagged some trends to watch.

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Oct 24 • 6:38 AM EDT • Business • businessinsider.com
Star Trek: Voyager - Across the Unknown - Delta Chronicles 2 DLC launches October 28!

The Delta Chronicles 2 DLC contains 5 new missions, 2 recruitable heroes, 2 new technologies, 3 NPC ships & adds the Q Logs as a voiced bonus feature.

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Oct 24 • 12:24 AM EDT • Entertainment • nickalive.net
Seven-region study ranks Northwest Arkansas at top in jobs and business growth, at bottom in average wages

Northwest Arkansas outpaced six peer metropolitan areas in job growth, business establishment growth and high-tech employment growth in 2025, according to the 2026 state of the Northwest Arkansas region report release Friday.

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Oct 23 • 8:35 PM EDT • Business • arkansasonline.com
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Health Brief: Making sense of Treasury’s biotech deal proposal

Pharma sees a potential catch in Washington’s latest effort to curb China’s biotech ambitions

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Oct 23 • 7:16 PM EDT • Health • washingtonpost.com
Apple’s official DIY repair guides for the iPhone Duo now available

Apple has published multiple repair guides and manuals for users and independent technicians looking to replace or repair individual components in the device.

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Oct 23 • 7:12 PM EDT • Technology • 9to5mac.com
General Dynamics names new GDIT president

Amy Johnson will lead General Dynamics Information Technology starting Nov. 3, bringing experience from General Dynamics Mission Systems.

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Oct 23 • 5:37 PM EDT • Business • virginiabusiness.com
Kentucky vs. Texas Tech game discussion and pregame reading

A great preseason test for the Kentucky Wildcats as they take on No. 19 Texas Tech in Rupp Arena.

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Oct 23 • 5:09 PM EDT • Sports • sports.yahoo.com