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Mike Vrabel reveals another key Patriots starter battling injury
Patriots coach Mike Vrabel revealed that running back Rhamondre Stevenson is dealing with an injury.
Mia Goth files for divorce from Shia LaBeouf
The former couple met while filming Lars von Trier’s “Nymphomaniac.”
Mia Goth files for divorce from Shia LaBeouf
Mia Goth has filed for divorce from Shia LaBeouf. The ‘Nymphomaniac’ costars quietly separated in 2025.
From 1800s to modern pharma: a Nobel-winning chemistry quest
Wednesday's Nobel chemistry prize crowned a series of advances that started in the 19th century and led to breakthroughs for modern pharmaceutical manufacturing.In 2001, US scientists William Knowles ...
Warning signs of diabetes; resources available through Tria Health and free health coaching
Free diabetes resources are available through Tria Health’s chronic condition management program and through a dedicated health coaching offering focused on diabetes education.
Purchase District Health Department selected to lead diabetes, obesity initiatives
Purchase District Health Department was recently selected to lead the Rural Community Hub for the Purchase region as part of the Rural Community Hubs for Chronic Care Innovation Program, constituting
Dodgers’ Yoshinobu Yamamoto makes MLB postseason history
Yamamoto delivers historic postseason performance for Dodgers.
Here Are Wednesday’s Top Wall Street Analyst Research Calls: Abbott Laboratories, AppFolio, Delek US Holdings, Flutter Entertainment, Honeywell Aerospace, Intuitive Surgical, Marvell, NetApp, and More
Pre-Market Stock Futures: Futures are trading lower as today’s oil and interest rates are higher. Baseball legend Babe Ruth was often credited with the saying, “Records are made to be broken,” and Tuesday was one of those days for the stock market. For the second straight day, all major indices ended higher, with only the […]
The Yankees still do themselves no favors
They’re gonna beat themselves all the way out of October.
Inside Sephora and Vogue Business’s Night Kicking Off a Global Cause
At the Sephora and Vogue Business event during Paris Fashion Week, the beauty retailer launched its global initiative Project Hearts Not Hate.
Pens Points: Crosby meets Ovechkin for first of final battles
Following Monday’s announcement that this would be Alex Ovechkin’s final NHL season, Pittsburgh Penguins and Washington Capitals fans likely peeked at the schedule to see how many more times the two generation-defining rivals would face off. Luckily for us, tonight is the first of four final regular season matchups between Ovechkin and Crosby. Puck drop […]
Dodgers SP Yoshinobu Yamamoto Makes MLB History in NLDS Win
The Los Angeles Dodgers are one win away from reaching the National League Championship Series for the third consecutive year.The Dodgers entered Game 3 of the NLDS against the Atlanta Braves needing a crucial win to take a 2-1 series lead. That is why they called on Yoshinobu Yamamoto to start the game. Yamamoto has […] The post Dodgers SP Yoshinobu Yamamoto Makes MLB History in NLDS Win appeared first on HEAVY.
'Carrie' reading list: Every library book Carrie picks has been banned
Let Carrie White (and everyone) read "The Handmaid's Tale".
Downtown San Diego sees boost from Padres postseason
The San Diego Padres' postseason run in the National League Division Series has provided a significant economic boost to downtown businesses.
Vikings’ QB Situation Sparks Major Bleacher Report Warning
The NFL trade deadline is not until Tuesday, November 10. However, several analysts have put together articles on ways teams can improve. For the Minnesota Vikings, Bleacher Report’s Moe Moton indicated that the Vikings should look at the quarterback position heading into the trade deadline.Kyler Murray has led the Vikings in the quarterback room this […] The post Vikings’ QB Situation Sparks Major Bleacher Report Warning appeared first on HEAVY.
Elizabeth Berkley says “DWTS” created ‘drama’ where it ‘didn’t exist’ when she was on show
The “Saved by the Bell” alum competed on the 17th season and was eliminated despite earning a perfect score.
Red Wings Fans React to Dylan Larkin Being Named No. 1 Star vs. Senators
Dylan Larkin had a goal and an assist and was named the No. 1 star as the Red Wings beat Ottawa 5-3 for their first win of the season.
Teen arrested over Facebook post mocking political official
Reform UK Wolverhampton leader Councillor Celia Hibbert and Reform UK activist Fraser discuss concerns over free speech in the UK on 'The Ingraham Angle.'
San Antonio tax preparing business owner sentenced to federal prison, ordered to pay $3.8 million
A San Antonio woman convicted of falsifying tax forms on behalf of her clients was sentenced to federal prison and ordered to pay more than $3.8 million dollars in restitution, the U.S. Department of Justice announced Tuesday.
Voters in 12 states face tight races for governor
The Cook Political Report has labeled four governor races as "lean Democrat" and three as "lean Republican."
Voters in 12 states face tight races for governor
The Cook Political Report has labeled four governor races as "lean Democrat" and three as "lean Republican."
Voters in 12 states face tight races for governor
The Cook Political Report has labeled four governor races as "lean Democrat" and three as "lean Republican."
Apple and LG team up on new smart home gear, starting with a lock, doorbell, and thermostat
LG on the label but Apple behind the scenes?
Eagles star tackle Lane Johnson retires due to 'personal reasons'
The Philadelphia Eagles learned Tuesday that star right tackle Lane Johnson decided to retire, citing 'personal reasons.'
Ben Affleck recreates iconic “Good Will Hunting” scene, swaps out Matt Damon for Kerry Washington
Affleck’s new thriller, “Animals,” premieres on Netflix on Oct. 9.
Elizabethton High School Health Academy expands as student interest grows
At 16 years old, Aubri Cline is already doing things she once thought would have to wait until college.
David Montgomery, Ollie Gordon, And All Our Must-Sit Fantasy Football Running Backs For Week 5
Our top must-sit fantasy football running backs for Week 5.
Jesse Marsch calls USA politics 'big talk' as Mauricio Pochettino praises Canada coach
Canada manager Jesse Marsch calls USA politics "big talk" while US coach Mauricio Pochettino praises his opposite number before Tuesday's game.
Charm Security Appoints Dr. Elizabeth Huppert as Behavioral Science Director
Former JPMorgan Chase Vice President and Behavioral Scientist joins to advance behavioral science in agentic AI for fraud, scams, and cybercrime.NEW YORK, NY / ACCESS Newswire / October 6, 2026 / Security today announced the appointment of Dr.
UAMS Receives Grant to Provide Telehealth Nutrition Services, Remote Monitoring in Clinics in Batesville, El Dorado
The University of Arkansas for Medical Sciences (UAMS) will integrate telehealth nutrition services and remote patient monitoring at two of its clinics to help patients better manage their diabetes and chronic health conditions.
Evan Williams praises Jonathan Gannon after Packers’ dramatic win
The Green Bay Packers leaned on their defense to preserve a 17-14 victory over the Tampa Bay Buccaneers on Sunday, with Evan Williams delivering a pair of crucial plays during the closing moments. The safety’s performance on Tampa Bay’s last drive also gave him another reason to admire the work of defensive coordinator Jonathan Gannon. [...]
Queen pays tribute to 'irrepressible' Jeffrey Archer
Tthe bestselling author and former politician died on Monday at the age of 86.
Block Club Chicago’s Free South Side Health & Wellness Fest Is Coming to Chatham
Join Block Club and community partners on Nov. 7 for activities and resources to help address health equity gaps. Join a fun run with Joabe Barbosa, get a free meal and more.
Best Fantasy Football waiver wire pickups for Week 5
The fantasy football season is in full swing, and with teams going on bye this week, waiver wire pickups are getting even more important.
Dani Carvajal set to remain in Madrid
Dani Carvajal is still a free agent and could soon make a surprise decision, according to the Spanish press. The right-back is expected to stay in the capital, although not at the club where he made ...
WEATHER REPORT: Notre Dame Fighting Irish vs Stanford Cardinal
This might be the most perfect weather we get this year at Notre Dame (unless you love snow in November).
DarioHealth Announces Independent Aon Analysis that Supports Estimated 2.5%-7.2% In-Year Reduction in Total Healthcare Costs
A component study of the independent review by Aon found $5,077 in annual savings and 23.5% fewer inpatient discharges per Dario user with type 2 diabetes...
Groundbreaking Ceremony Celebrates Aberdeen's Public Works Building, New Business Park
Past and present city officials gathered with numerous public works employees and state and local economic development officials to celebrate the start of
'Nobody Cares' review: Laura Benanti sings for laughs
Tony-winner Laura Benanti brought her solo comedy cabaret 'Nobody Cares" to the Wallis and the show is now headed to South Coast Repertory.
With Uzbekistan open for business, investors watch reform staying power
When Nika Kurdiani began to plot London-listed Georgian lender TBC Bank's expansion into Uzbekistan around 2018, he had to bring plastic bags full of banknotes to pay restaurant bills.
Arkansas campaign ad sparks conservative backlash for portraying lazy welfare recipient as white
A new video from Arkansas Gov. Sarah Huckabee Sanders was standard issue Republican messaging for promoting her state’s stricter rules for people on Medicaid
SAFETY ALERT | School system closed Tuesday tied to skin-related health concern
The system said the closure comes out of an abundance of caution and allows the schools to be deep cleaned.
Jim Bakker, disgraced 1980s televangelist, dies at 86
Jim Bakker, pioneering televangelist, dies at 86. His wife Lori made the announcement.
FBI Director Kash Patel and country singer Alexis Wilkins are engaged
FBI Director Kash Patel and country singer Alexis Wilkins, who is also an ambassador for Turning Point U.S.A., announced their engagement on Instagram after dating since 2023.
Upcoming Trump rally at Freeman Coliseum draws mixed reaction from San Antonio voters
Long-term "Food Is Medicine" program improves cardiometabolic health in adults
Providing people with nutritious foods can improve the management of chronic metabolic diseases such as type 2 diabetes and hypertension.
Free Finance Fair planned at Santa Fe Business Incubator
The free event will be held from 8:30 to 10 a.m. Thursday at the Santa Fe Business Incubator.
Countries race to provide oral health care for all in 100-Day Sprint across Asia
Twenty Asian countries and areas across the WHO Western Pacific and South-East Asia regions vowed to strengthen essential oral health benefits as part of a “100-Day Sprint” initiative, during the 16th Asian Chief Dental Officers Meeting held from 27 to 29 September in Kota Kinabalu, Malaysia. The meeting marked the midpoint of the 100-day sprint bolstering support for countries to develop essential oral health benefit packages that can be integrated into national universal health coverage plans. Convened by the two WHO regional offices and the Malaysian Ministry of Health as the Secretariat, the meeting brought together national oral health leaders from 20 Asian countries, staff from all levels of WHO, WHO collaborating centres and other development partners. Participating countries and areas included: Bangladesh, Bhutan, Brunei Darussalam, Cambodia, China, Hong Kong (SAR) China, India, Indonesia, Japan, Lao People’s Democratic Republic, Malaysia, Maldives, Mongolia, Nepal, the Philippines, Singapore, Sri Lanka, Thailand, Timor-Leste and Viet Nam. Participants reviewed progress and refined proposals using the WHO Service Package Delivery and Implementation (SPDI) Platform. Countries conducted bottleneck analyses across four key areas: service delivery, workforce, access to essential medicines and health products, and health financing. They identified practical actions to address implementation challenges and refined proposed revisions to their national oral health benefit packages. “There is no health without oral health. Through the 100-Day Sprint, countries are advancing the implementation of the Western Pacific regional implementation plan on oral health and strengthening progress towards universal health coverage,” noted WHO Regional Director for the Western Pacific Dr Saia Ma'u Piukala. Participants identified bottlenecks and proposed workable solutions to strengthen access to essential oral health care through primary health care, sharing experiences and discussing how best to translate policy commitments into feasible and sustainable action at the country level. Malaysian Minister of Health Datuk Seri Dr Dzulkefly Ahmad highlighted the importance of prevention and primary health-care approaches to improve oral health: “Oral diseases can have lifelong consequences, yet many are preventable. By integrating essential oral health care into primary health care and promoting prevention in schools and communities, we can improve oral health across the life course.”The WHO team led by Dr Huong Tran, Director of the Division of Health Promotion, Disease Prevention and Control of the WHO Western Pacific Region and national oral health leads from over 20 Asian countries visited the SK Pekan Putatan School, Sabah for school oral health programme including flouride mouth rinsing. © WHO / V. ChaudharyDr Huong Tran, Director of the Division of Health Promotion, Disease Prevention and Control for the WHO Western Pacific Region, emphasized key collaborative roles WHO can play. “Oral diseases are the most common noncommunicable diseases, yet many can be prevented and treated through essential oral health services delivered at the primary health-care level,” she said. “By sharing experiences and using WHO tools such as the SPDI Platform, countries are accelerating progress towards universal health coverage for oral health.” “Integrating oral health into broader health services is essential for reducing inequities, expanding access and recognizing oral health as an integral component of overall health and well-being. The 100-Day Sprint provides an important opportunity to translate this commitment into practical action and ensure that quality oral health services reach all people, especially those most in need,” said Dr Suman Rijal, Director of the WHO South-East Asia regional Department of Healthier Populations and Noncommunicable Diseases. As host of the meeting, Malaysia showcased ongoing efforts to strengthen oral health care through primary health care and prevention-focused approaches, while providing a platform for countries across the two WHO regions to exchange experiences and accelerate progress towards universal health coverage for oral health. “WHO is encouraged by Malaysia's leadership in addressing the burden of oral diseases and advancing universal health coverage for oral health through practical, country-led action,” said Dr Rabi Abeyasinghe, WHO Representative to Malaysia, Brunei Darussalam and Singapore. Countries will continue to refine and figure costs for national oral health benefits during the remaining sessions of the 100 days. These efforts support implementation of the WHO Global strategy and action plan on oral health 2023–2030, while also helping to expand access to essential oral health services through stronger and more equitable health systems across the WHO Western Pacific and South-East Asia regions.______________For more information, or to arrange media interviews, contact: WHO Regional Office for the Western Pacific: wprocom@who.int WHO Regional Office for South-East Asia: SEMediaRelations@who.int
Hunter Green Named Ray’s Eight, Punting Matchup with Iowa
Washington punter Hunter Green was named one of the “Ray’s Eight” punters of the week by the Ray Guy Award after his 310-yard punting performance at USC. Green punted six times for an average of 51.7 yards with three pinned inside the 20-yard line. Two of his punts were downed at the one-yard line. His …
Hawaiʻi Island program bridges the gap between food and health
Through a partnership with the Hawaiʻi Island Community Health Center and the Food Basket, the initiative provided 25 patients with weekly food boxes that are completely locally sourced to measure how regular access to healthy, local foods would impact their overall health.
Reggie McFadden death: Comedian and actor dies at 57
'In Living Color' actor and comedian Reggie McFadden has died at the age of 57. His family received word from the State Department of his death in Tanzania.
A lawsuit accuses Starbucks of mislabeling 8 'sugar-free' protein drinks
Starbucks is facing a consumer lawsuit over claims that the protein drinks labeled as “sugar-free” on its cafe menus may actually contain more sugar than a Reese’s peanut butter cup.
Volkswagen exec starts in new CarMax C-suite role
Elizabeth Dirgins was named CarMax's inaugural chief digital and customer officer and executive vice president.
CMS student among top 30 finalists nationwide in science competition
Isabella Garry is being honored for a project exploring whether natural materials can remove microplastics from simulated stomach fluid.
Ted Cruz Says JD Vance’s ‘Political Bomb-Throwing’ Shows He’s ‘Insecure’ Ahead of 2028 Election
While Vice President JD Vance might have been floated as a potential frontrunner for the Republican presidential nomination in the 2028 election, Senator Ted Cruz is doing his part to keep the party’s...
Childhood Housing Assistance Linked to Better Health Decades Later, Children's Mercy Study Finds
A child’s home may shape their health well into adulthood. New research led by Dr. Jeffrey D. Colvin, pediatrician, health services researcher and principal investigator at Children’s Mercy found that children who receive housing assistance are significantly less likely to develop diabetes and high blood pressure, also known as hypertension,...
Mike Vrabel: Efton Chism III has earned more opportunities
On Sunday, OBJ met EC3.
Didier Fuentes Makes MLB History During Atlanta Braves Win
Atlanta Braves right-hander Didier Fuentes shut the Los Angeles Dodgers down in Game 2 of the NLDS.
Banijay Entertainment Consolidates U.S. Operations to 'Banijay America' Under CEO Ben Samek
Banijay Entertainment Oct. 5 announced it is consolidating its U.S. operations under a new moniker, Banijay America, under the direction of CEO Ben Samek, who reports to Jane Turton, deputy CEO of Banijay Entertainment. The company is restructuring its operational footprint to centralize leadership and operational support while keeping its individual production labels creatively independent. … Continue reading "Banijay Entertainment Consolidates U.S. Operations to ‘Banijay America’ Under CEO Ben Samek"
Lightsaber-like plasma antenna uses laser-ionized air to transmit radio waves
Researchers have demonstrated a technique that uses a laser to produce a plasma beam antenna capable of transmitting radio waves. The article, "Laser-Induced-Plasma-Filament Antenna Transmitting 30 MHz ...
Team Dresch, pioneering WA punk rock band, returns with ‘Furthermore’
Team Dresch are finally putting out their third album, “Furthermore,” the long-awaited follow-up to 1996’s “Captain My Captain.”
Mystery Hill launches first after dark experience
BLOWING ROCK — Mystery Hill, home of North Carolina’s only Natural Gravitational Anomaly, will remain open after sunset this fall for Mystery Hill After Dark, a new evening event series
Whole Hog Politics: Audience capture and the GOP’s #content trap
You did not, I hope, have to take any notice of an empty online furor over Arkansas’s Republican Gov. Sarah Huckabee Sanders’s campaign ad that cast a young, white male as a welfare freeloader redeemed from sloth by...
Offensive Line Looks Offensive: Spartans Rank Last in Sacks Allowed
From personnel shifts to coaching failures, a crumbling front wall has left the Spartans reeling as record-breaking sack numbers threaten to derail the Pat Fitzgerald era.
Former press secretary Karoline Leavitt lands her next gig: Fox News contributor
Former White House press secretary Karoline Leavitt is joining Fox News as an on-air contributor starting Nov. 1.
Paid influencers and political ads - Illinois Times, the capital city's source of news, politics, arts, entertainment, culture
My associate Isabel Miller and I worked on a story last week about paid influencers in campaigns. We decided to look into it after reading news reports about how the Chicago Teachers Union has been using paid influencers in its battle to control the elected Chicago school board and Chicago Mayor Brandon Johnson is also […]
Should Aging Be Called a Disease? Scientists Are Rethinking What It Means to Grow Older
What if the next big target in medicine is getting older itself? Researchers are taking that possibility seriously, with new tools, new clinics, and growing FDA attention. Instead of waiting for diabe...
Dennis Hastert, longtime Republican House speaker who went to prison, dies at age 84
Dennis Hastert, who served as House speaker longer than any other Republican but later was sent to prison in a hush-money case, has died.
Ohio Democrats’ path to the governor’s office runs through rural areas that had turned against them
Democrats say their nominee for governor in Ohio, Dr. Amy Acton, represents the party’s best chance in years to win that office.
Research Shows These 10 Diets Are Linked to Healthier Aging
A new study found that many different diets can slow biological aging.
Spooky season watchlist
In October 2024, I drove into Gambrill State Park after dusk and joined others carrying blankets and lawn chairs — flashlight streams lighting the road and parking lot — as
Are aliens real? Here’s what science can and can’t prove
Some scientists believe the sheer number of stars, planets and potentially habitable environments in space makes extraterrestrial life plausible. But plausibility is not proof. Despite decades of sear...
Yale School of Medicine On the Science of Childhood Anxiety, Say, Anxiety Disorders Are the Most Common Mental Health Challenges In Youth
Credit: Matt Bradbury October 5, 2026 - By Isabella Backman - Anxiety disorders are the most common mental health challenges in youth. Left untreated, they can disrupt the lives of both children and their families. The good news is that with intervention, most children will overcome these conditions. Across Yale School of Medicine, scientists are working to understand anxiety at every level, from common anxious behaviors to molecular biomarkers in the brain. They are using their findings to develop and disseminate new evidence-based treatments for childhood anxiety. Today, the go-to treatment for childhood anxiety disorders is cognitive behavioral therapy (CBT). This is a form of psychotherapy that teaches children skills for confronting anxious thoughts and helps them practice managing situations that cause anxiety. While it is the gold-standard treatment backed by considerable scientific evidence, up to 50% of children will not see sufficient benefit from CBT alone. Wendy Silverman, PhD, Alfred A. Messer Professor in the Child Study Center, co-directs the Anxiety and Mood Disorders Program alongside Eli Lebowitz, PhD, associate professor in the Child Study Center. One of their main interests is learning how to improve outcomes beyond CBT. “We’re developing cutting-edge, research-based knowledge that can reduce the suffering that anxiety causes children and their families,” says Silverman. Changing parent behavior YSM experts are investigating how to improve CBT outcomes for children by involving the parents. Silverman’s research has uncovered two main components of parent intervention that improve childhood anxiety: not enabling children to completely avoid the things that make them anxious and taking steps to enhance their autonomy. Parents may unintentionally reinforce their child’s anxiety by allowing them to avoid what makes them anxious. They also may unintentionally limit the children’s sense of autonomy by being overly intrusive. “One of the things that we take pride in is that we’ve focused on trying to understand what parents need to do, and to test our ideas and see if changing the parents’ behaviors is enhancing the effects of CBT,” Silverman says. “Our findings thus far suggest that they do." As much as CBT can be helpful, it can also be challenging to get one’s child to do the necessary steps for CBT to work. This is one important reason why Lebowitz created a novel intervention program for parents named Supportive Parenting for Anxious Childhood Emotions (SPACE). Existing intervention programs often teach parents to act as therapists for their child, such as training them on how to practice breathing exercises. “It makes sense, but this doesn’t work very well in practice,” says Lebowitz. “And part of the reason, I think, is that it’s not easy to get your kid to do things, especially if they’re not excited about doing it.” SPACE is unique because it focuses entirely on parent involvement and changing parental behavior—children are not involved in the sessions. For example, parents learn how to use supportive messages that convey confidence that their child can tolerate and manage distress. “It might sound like a parent saying to a child, ‘I get that this is really hard for you, but I know that you can handle it,’” Lebowitz says. The program also works with parents to identify the ways in which they are accommodating anxious behaviors. “We’ll pick one thing that parents are doing that is an accommodation and help them make a detailed plan for how they’re going to change that,” Lebowitz explains. Treating Anxiety in Children and Adolescents Much of the existing research on SPACE has focused on parents of children under age 14. Ongoing studies are now exploring its use with parents of older teens. “Both anxiety and accommodation can interfere with normative developmental shifts during the teen years, including increased autonomy and individuation from parents,” says Rebecca Etkin, PhD, associate research scientist in the Child Study Center. “In this sense, SPACE may be particularly well-suited for anxious teens and their parents. We want to see whether it is effective during this distinct developmental window.” Unfortunately, many families in need of CBT face barriers, including limited availability of services and geographic constraints. One way to improve access is digital interventions. Silverman and her team are developing an evidence-based digitized intervention program for parents that they can access directly from their computer or smart phone. “The work we’re doing will be one of the very few parent interventions that is digitized and importantly tested for effectiveness,” she says. Creating interventions for anxiety-related challenges Silverman and Lebowitz recently received a generous gift to develop and test other interventions that help parents reduce other child anxiety-related behavioral and emotional difficulties, such as restrictive eating and unexplained somatic symptoms. One of these projects in particular focuses on understanding the risks of social media and its potential benefits, including offering a sense of connection. “A lot of research has focused on the idea that social media is harmful and the less of it the better,” says Lebowitz. “But we actually see is that this is not quite right—there are negatives, but there are also positives. So, we’re trying to get a little bit more nuanced of a picture.” The team is working with teens with social anxiety and their parents over an extended period to better understand their social media habits and how their anxiety levels affect engagement with different platforms. The teens will answer questions sent to an app on their phones about mood and social media usage in an effort to capture emotional responses as they unfold. “We hope to develop interventions that can help make the best of social media while protecting against the more problematic effects,” Lebowitz says. The brain’s role in anxiety Researchers are also testing therapies to address anxiety at the neurological and molecular levels. In collaboration with Dylan Gee, PhD, professor of psychology in Yale's Faculty of Arts and Sciences, and Hilary Blumberg, MD, John and Hope Furth Professor of Psychiatric Neuroscience at Yale School of Medicine, Lebowitz and Silverman are using brain imaging to identify changes in a child’s brain before and after parents enroll in SPACE. In one study, children viewed anxiety-inducing images while undergoing magnetic resonance imaging (MRI); the researchers conducted scans with and without the children’s parents nearby. Before SPACE, children’s brains were better able to activate the regulatory circuitry needed to turn off an anxious response when their parents were nearby. But after SPACE, children could activate this circuitry even without the parent around. “As parents work on gradually reducing some of their accommodations, you can see a child get better at regulating their own fear system in the brain,” Lebowitz says. “It’s remarkable.” Research into the molecular underpinnings of anxiety can also inform new childhood anxiety treatments. In a recent study, Lebowitz, Silverman, and Flora Vaccarino, MD, Harris Professor in the Child Study Center, discovered that a protein known as fibroblast growth factor 2 (FGF2) could be protective from the toxic effects of stress. FGF2 levels in children and their parents were linked to the children’s risk of developing anxiety and depression, the study showed. The findings could help explain why some children who are exposed to early life trauma such as poverty or abuse are more prone to developing mental health disorders. And FGF2 could be a target for treatment. “This is very novel because it starts to give a clue to what is the molecular chain that connects those lived experiences to the actual psychological outcomes,” Lebowitz says. New ways to study and treat childhood anxiety Michael Crowley, PhD, associate professor in the Child Study Center, collaborates with Silverman and Lebowitz to study the role that attention plays in development and maintenance of childhood anxiety. There is a large body of research that shows that anxious children, like anxious adults, are prone to focus on threatening stimuli such as angry faces compared with neutral faces. This has led to innovative interventions that involve attention retraining. The idea is that if experts train children to look away from threatening stimuli, it may reduce their anxiety—especially children with social anxiety who are most prone to attend to threats. The researchers have just completed a clinical trial for attention retraining with 10- to 14-year-olds with social anxiety disorders and are currently analyzing the findings. Besides this innovative attention retraining research, as Crowly notes, “I like to design tasks that are engaging to kids,” Crowley says. “My goal is to assess something without the kids knowing what we are assessing.” With this goal in mind, Crowley has created a virtual game, named Boom, to study threat processing in children with anxiety disorders. The game is similar to that of hot potato—the child and three digital players take turns virtually passing a ball to each other’s gloves. At some point, the ball turns into a bomb, and as the bomb lands in each player’s glove, the outline of the glove turns yellow. The goal is to avoid having the bomb go off in your glove. What isn’t obvious is that the game is designed to measure different types of threatening stimuli, both ambiguous and direct. In the game, the direct threat occurs as the bomb is traveling towards your glove. The ambiguous threat is the yellow outlined glove as it is unknown where the bomb will travel next. While children play the game, Crowley’s team measures their brain activity using electroencephalography (EEG). The researchers have discovered that in kids with anxiety, the brain reacts more strongly to ambiguous threats than it does in their peers, but less strongly to direct threats. They believe that the initial abnormally large brain response to not knowing where the bomb is going impairs the brain's ability to properly respond when the threat is actually traveling the child’s way. “The brains of children with anxiety are unable to differentiate between threats you need to do something about and those that are not your problem.” Michael Crowley, PhD, develops innovative games for studying anxiety in children and adolescents.Credit: Matt Bradbury Based on these insights, Crowley hopes to study whether interventions like attention training could restore appropriate threat processing. Crowley’s team is also working on a test called the Balloon Risk Avoidance Task, which evaluates risk-taking and avoidance behaviors. It features a digital balloon that is full of air and about to burst. Kids have six seconds to let air out of the balloon. The more air they let out, the less risk they face that the balloon will pop. But at the same time, the balloon becomes less valuable as it deflates. “The more air you keep in the balloon, the more points you get,” Crowley explains. So far, the researchers have found that when the balloons pop unexpectedly, teens with social anxiety show distinct brain responses. Studying these responses can help psychologists understand the underlying pathways driving the various manifestations of anxiety. The genetics of anxiety When Thomas Fernandez, MD, associate professor in the Child Study Center and of psychiatry, was still in training, there was a lot of excitement about understanding the genetics associated with autism spectrum disorder. Since then, scientists have identified around 250 genes associated with autism. The genetic contribution to anxiety disorders, on the other hand, has historically received less attention. Anxiety is less heritable than autism, but the genetic contribution for anxiety disorders that emerge in childhood may be higher than for anxiety disorders overall. While scientists estimate the heritability of anxiety disorders in general to be around 30% to 50%, some studies suggest higher heritability for certain childhood-onset anxiety presentations. “I saw firsthand how researchers in the field went about finding vulnerability genes for autism,” Fernandez says. “So, we’re using a very similar playbook for childhood anxiety.” “I saw firsthand how researchers in the field went about finding vulnerability genes for autism. So, we’re using a very similar playbook for childhood anxiety.” Thomas Fernandez, MD Associate Professor In the Child Study Center and in Psychiatry Now, Fernandez and Emily Olfson, MD, PhD, assistant professor in the Child Study Center, are studying children and their parents to identify genetic changes that are present in the child but not the parents, known as “de novo mutations.” “All of us have some de novo mutations—maybe about 50 to 100 sprinkled throughout the genome,” Olfson says. “But when they occur within the coding regions of genes, they can be really disruptive.” Previous research shows that people with autism have higher rates of damaging de novo mutations than the general population. In 2022, Olfson, Lebowitz, Silverman, and Fernandez published a study on 68 children and their families that found that children with anxiety had similarly high levels of these mutations. Studying de novo mutations can help point the researchers to where they should be looking for genes associated with anxiety. “The end game is using the genes to steer us toward the right part of biology that we can then target to come up with better treatments,” Fernandez says. Building on those findings, the team is now studying more families to better understand how these de novo mutations, along with other genetic and environmental factors, shape pediatric anxiety disorders. They recently received a National Institutes of Health grant to enroll 750 new families over the next five years. Olfson is the principal investigator, with co-investigators Lebowitz, Fernandez, Silverman, and Shuangge Steven Ma, PhD, department chair and professor of biostatistics at Yale School of Public Health. Neurodevelopment, Risk Genes, and Mental Health Conditions - The Olfson Lab Joel Gelernter, MD, Foundations Fund Professor of Psychiatry, is interested in how different anxiety disorders differ genomically. “We are studying social phobia, panic disorder, and generalized anxiety disorder, working to understand why people differ in their risk to these specific anxiety disorders and evaluating various risk factors,” he says. Gelernter was recently involved in one of the largest studies to date of the genomics underlying anxiety disorder. The study included around 122,000 people with anxiety disorders and around 730,000 without. It found that some genetic differences associated with anxiety were linked to signaling that helps reduce overactivity in the nervous system. Many anxiety medications available today work by targeting this process. “It’s nice when the biology that you get out of a large genome-wide study ratifies things that we already know because that can help increase confidence in further findings from the study,” Gelernter says. Uncovering the neurobiology of psychiatric disorders John Krystal, MD, Robert L. McNeil, Jr. Professor of Translational Research and chair of the Department of Psychiatry, is interested in the neurobiology of psychiatric disorders, including post-traumatic stress disorder (PTSD), of which anxiety is a major symptom. In the late 1980s, Krystal’s team discovered that the drug yohimbine activated symptoms in patients with PTSD. “This was the first time we could link a specific biological mechanism to the symptoms of PTSD,” Krystal says. At the time, he adds, this finding was highly controversial. “A lot of people felt that PTSD was a purely psychological syndrome that didn’t have an underlying biology.” Since then, Krystal has dived deep into understanding the neurobiology of PTSD to learn how to better treat it. His team is evaluating the use of ketamine and psychedelics. These would be among the first treatments to be developed specifically for PTSD. They may also be applicable for other disorders including anxiety disorders, Krystal adds. An important gap in PTSD treatment is the absence of biological tests that inform how to best help patients manage their PTSD symptoms. A doctor doesn’t diagnose cancer based on how they feel. Rather, they use tests of the biology of the cancer to determine the best course of treatment. “And we can’t do that in any psychiatric disorder other than Alzheimer’s disease,” Krystal says. “But now we are building a foundation for this approach to the treatment of anxiety disorders for the first time.” Source: Yale School of Medicine
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Twenty Asian countries and areas across the WHO Western Pacific and South-East Asia regions vowed to strengthen essential oral health benefits as part of a “100-Day Sprint” initiative, during the 16th Asian Chief Dental Officers Meeting held from 27 to 29 September in Kota Kinabalu, Malaysia. The meeting marked the midpoint of the 100-day sprint bolstering support for countries to develop essential oral health benefit packages that can be integrated into national universal health coverage plans. Convened by the two WHO regional offices and the Malaysian Ministry of Health as the Secretariat, the meeting brought together national oral health leaders from 20 Asian countries, staff from all levels of WHO, WHO collaborating centres and other development partners. Participating countries and areas included: Bangladesh, Bhutan, Brunei Darussalam, Cambodia, China, Hong Kong (SAR) China, India, Indonesia, Japan, Lao People’s Democratic Republic, Malaysia, Maldives, Mongolia, Nepal, the Philippines, Singapore, Sri Lanka, Thailand, Timor-Leste and Viet Nam. Participants reviewed progress and refined proposals using the WHO Service Package Delivery and Implementation (SPDI) Platform. Countries conducted bottleneck analyses across four key areas: service delivery, workforce, access to essential medicines and health products, and health financing. They identified practical actions to address implementation challenges and refined proposed revisions to their national oral health benefit packages. “There is no health without oral health. Through the 100-Day Sprint, countries are advancing the implementation of the Western Pacific regional implementation plan on oral health and strengthening progress towards universal health coverage,” noted WHO Regional Director for the Western Pacific Dr Saia Ma'u Piukala. Participants identified bottlenecks and proposed workable solutions to strengthen access to essential oral health care through primary health care, sharing experiences and discussing how best to translate policy commitments into feasible and sustainable action at the country level. Malaysian Minister of Health Datuk Seri Dr Dzulkefly Ahmad highlighted the importance of prevention and primary health-care approaches to improve oral health: “Oral diseases can have lifelong consequences, yet many are preventable. By integrating essential oral health care into primary health care and promoting prevention in schools and communities, we can improve oral health across the life course.”The WHO team led by Dr Huong Tran, Director of the Division of Health Promotion, Disease Prevention and Control of the WHO Western Pacific Region and national oral health leads from over 20 Asian countries visited the SK Pekan Putatan School, Sabah for school oral health programme including flouride mouth rinsing. © WHO / V. ChaudharyDr Huong Tran, Director of the Division of Health Promotion, Disease Prevention and Control for the WHO Western Pacific Region, emphasized key collaborative roles WHO can play. “Oral diseases are the most common noncommunicable diseases, yet many can be prevented and treated through essential oral health services delivered at the primary health-care level,” she said. “By sharing experiences and using WHO tools such as the SPDI Platform, countries are accelerating progress towards universal health coverage for oral health.” “Integrating oral health into broader health services is essential for reducing inequities, expanding access and recognizing oral health as an integral component of overall health and well-being. The 100-Day Sprint provides an important opportunity to translate this commitment into practical action and ensure that quality oral health services reach all people, especially those most in need,” said Dr Suman Rijal, Director of the WHO South-East Asia regional Department of Healthier Populations and Noncommunicable Diseases. As host of the meeting, Malaysia showcased ongoing efforts to strengthen oral health care through primary health care and prevention-focused approaches, while providing a platform for countries across the two WHO regions to exchange experiences and accelerate progress towards universal health coverage for oral health. “WHO is encouraged by Malaysia's leadership in addressing the burden of oral diseases and advancing universal health coverage for oral health through practical, country-led action,” said Dr Rabi Abeyasinghe, WHO Representative to Malaysia, Brunei Darussalam and Singapore. Countries will continue to refine and figure costs for national oral health benefits during the remaining sessions of the 100 days. These efforts support implementation of the WHO Global strategy and action plan on oral health 2023–2030, while also helping to expand access to essential oral health services through stronger and more equitable health systems across the WHO Western Pacific and South-East Asia regions.______________For more information, or to arrange media interviews, contact: WHO Regional Office for the Western Pacific: wprocom@who.int WHO Regional Office for South-East Asia: SEMediaRelations@who.int
WHO joins Pre-COP31 to advance climate action that delivers for people’s health
The World Health Organization (WHO) is joining Pacific leaders, governments and partners at Pre-COP31 in Fiji from 5 to 8 October to advance health priorities in climate action and strengthen the Pacific voice ahead of the 31st Conference of the Parties (COP31) to the United Nations Framework Convention on Climate Change (UNFCCC).COP31, to be held next month in Antalya, Türkiye, marks an important step for global climate and health action. Health is one of the 10 priority themes of the COP31 Action Agenda, “Dynamic and Resilient Health Systems”, and a dedicated Health Day will take place on 9 November, the first day of COP31. The inclusion of health reflects growing global recognition that climate action and health are closely connected. The climate crisis is affecting population health globally. Across the WHO Western Pacific Region, which includes Pacific island countries and areas, the consequences of climate change include extreme heat, cyclones, floods, rising sea levels, food and water insecurity, infectious diseases and disruptions to essential health services. The Pacific in particular faces additional challenges. A recent review of 76 hospitals in 14 Pacific island countries found that 62% of health facilities are located within 500 metres of the sea or a river, leaving them particularly exposed to flooding, storm surges and sea-level rise.Bringing Pacific priorities to the global climate agendaThe Pacific Pre-COP31 provides an important opportunity for Pacific countries and partners to consolidate regional priorities and bring the experiences and leadership of Pacific communities into global climate discussions.Pacific countries have been advancing practical approaches to protect health in a changing climate, including strengthening climate-resilient health systems, improving preparedness for extreme weather events, building resilient health infrastructure and mobilizing climate finance for health. “This Pre-COP is an important moment for the Pacific, bringing global climate discussions to a region that has long been at the forefront of the climate crisis. It provides an opportunity for Pacific countries and areas to set their priorities, experiences and leadership on the global stage, and to ensure that the realities of Pacific communities are genuinely reflected in the decisions made on climate action,” said Dr Saia Ma’u Piukala, WHO Regional Director for the Western Pacific.Throughout this week, WHO will co-convene and participate in high-level discussions and events focused on climate and health, climate resilience, adaptation, financing and implementation. “Climate finance is essential for resilient and healthy Pacific communities,” emphasized Dr Mark Jacobs, WHO Representative to the South Pacific and Director of Pacific Technical Support. “We must ensure that financing reaches the people, communities and essential services most exposed to climate risks, supporting locally defined priorities and investments.”WHO will work with partners to strengthen the integration of health considerations across climate policies and investments, including national climate plans and resilience initiatives.Health as a driver of climate actionAmid the risks to health and pressures on health systems, well-strategized and implemented climate action can deliver significant health benefits. Investments in clean energy, sustainable transport, resilient infrastructure, food systems and nature-based solutions have proven to reduce health risks while contributing to climate mitigation and adaptation.“Climate action is truly an investment in health. Cleaner energy, healthier food systems and climate-resilient health services can protect lives while building stronger communities. We now need to turn these opportunities into action and make health a core part of climate investments,” said Dr Sandro Demaio, Director and Head of Office, WHO Asia-Pacific Centre for Environment and Health in the Western Pacific Region. “These benefits demonstrate that climate action is not only about reducing future risks. It is also an opportunity to improve lives today while building healthier, safer and more resilient societies.”At COP31 next month, WHO will also support the Health Pavilion, which will bring together the global health community and partners to advance health and equity within climate negotiations. With COP31 poised to move health higher on the global climate agenda, WHO will continue working with countries and partners across the Western Pacific Region and globally to strengthen climate-resilient and low-carbon health systems, and ensure that climate action protects and improves people’s health.____________________Media contactsElizabeth Bennett, WHO Asia-Pacific Centre for Environment and Health in the Western Pacific Region, elizabeth.bennett@who.intJulia Dongwhan Shin, WHO Asia-Pacific Centre for Environment and Health in the Western Pacific Region, dong.shin@who.intWHO Western Pacific Communications, wprocom@who.int
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