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Students get a head start on undergraduate research in STEM fields
High school seniors and incoming UT San Antonio freshmen work alongside faculty mentors to engage in hands-on research.
Curiosity Blog, Sols 4995-5001: 5,000 (Martian) Days on Mars
Written by William Farrand, Senior Research Scientist, Space Science Institute
Bangladesh fights world's worst measles outbreak as vaccination gaps fuel spread
Bangladesh, which once came close to eliminating measles, is facing its worst outbreak on record, with 999 suspected and confirmed measles-related deaths reported since March as hospitals struggle with overcrowding, shortages and a continuing influx of sick children.
Playing politics with security: Jerusalem must review UK privileges amidst sanctions
Britain and Israel have genuine strategic interests in common even when their governments disagree sharply, but diplomatic relations require reciprocity.
MidCap Business Credit Closes $10MM Asset-Based Credit Facility for Paper Converter
MidCap Business Credit closed a $10 million asset-based credit facility for a privately held paper converter specializing in custom paper products for
Haywood Choral Society welcomes new singers for fall season
Rehearsals for the fall season of the Haywood Choral Society will begin on Monday, Sept. 14, at First United Methodist Church of Waynesville, 566 S. Haywood St.
Guess Whose Back!? Dbacks 5, Royals 3. F/11
On Tuesday the Dbacks were able to get to a season high 10 games over .500 as they beat the Kansas City Royals in 11 innings. The story of the game was Corbin Burnes’ return to the team, but the guys that stole the show at the end were of an unlikely variety as there […]
Nebraska Senator Tanya Storer: Law requires brand committee members’ principal business ‘raising cattle’
Last week, the gubernatorial appointments to the newly restructured Nebraska Brand Committee were announced by the Governor’s Office. Under LB1187, the committee should be comprised of five district representatives plus one representative who owns or...
First Real Canon EOS R8 Mark II Images Surface Alongside Full Specs & Pricing
Authentic photos of the Canon EOS R8 Mark II have leaked online, giving a first real look at its controversial angular design, rear joystick, and full specs.
Astrocyte changes may explain how stress affects mental health
A new study led by UCLA Health researchers has identified a specific type of brain cell and a tiny structure on its surface that changes when the body is under stress, which may help explain why stress can lead to anxiety and depression.
Qunabox Group Opens '99 Quna Festival,' Debuting Consumer-Facing Physical AI Entertainment
Hong Kong-listed Qunabox Group Limited (0917.HK) opened its "99 Quna Festival" here on Sept. 9, putting its consumer-facing physical AI entertainment business in the spotlight for the first time.
Major Kingdom Hearts 4 leak surfaces, new worlds revealed
New worlds have just been revealed for Kingdom Hearts 4 as part of a major leak for the game.
Commanders’ Sonny Styles Gets Strong Prediction Before Eagles Game
The Washington Commanders will look to get off to a 1-0 start when they face the Philadelphia Eagles in Week 1 on Sept. 13. After missing the playoffs last season, the Commanders are looking for a bounce-back campaign.One of the young players the team will be counting on is linebacker Sonny Styles, whom they took […] The post Commanders’ Sonny Styles Gets Strong Prediction Before Eagles Game appeared first on HEAVY.
Undefeated Anthony Wint Books Second UFC Fight in 43 Days
Former NFL player Anthony Wint has booked his second UFC fight in 43 days. The undefeated athlete out of Homestead, Florida, fights on the UFC 332 card on October 3 in Salt Lake City, Utah. He takes on promotional newcomer Lucas Armand in the heavyweight division. The UFC announced the fight on the Dana White’s […] The post Undefeated Anthony Wint Books Second UFC Fight in 43 Days appeared first on HEAVY.
Trump’s Ability to Channel Voter Concerns Is Tested as Republicans Gather in Dallas
As Republicans face down tough midterm elections, President Trump has appeared out of step with the party on Iran, the economy and other issues.
Browns Face Blowback After Latest Deshaun Watson Announcement
The Browns latest decision with Deshaun Watson isn't sitting well. The post Browns Face Blowback After Latest Deshaun Watson Announcement appeared first on HEAVY.
Emanuel Wilson cleared for Week 1
Emanuel Wilson will be available for the Seahawks in Week 1.
SK hynix Charts Its Business and Technology Direction at the 2026 Future Forum—”Now Is the Golden Time to Leap Forward”
▲ SK hynix Vice President Jaewuk Ju, head of the Smart Manufacturing Technology/AX Advance department, delivering the first keynote presentation
The Trump administration slams Ford for its ties to China
The Trump administration on Tuesday expressed “profound concern” to carmaker Ford about its alleged ties to Chinese technology and manufacturing.
New Apple CEO to face first test with foldable iPhone launch
Apple is expected to unveil a slew of new and updated devices, including a long-rumored foldable iPhone, when it holds its annual late-summer hardware event on Wednesday in Cupertino, California.The tech giant is expected to finally reveal a long-awaited foldable iPhone, currently rumored to be called the iPhone Ultra, which will start at $2,000, according to reports.
Persona 6, Kingdom Hearts IV, and other Steam Achievements surface in large-scale leak
Steam Achievement lists for major titles like Persona 6 and Kingdom Hearts IV have surfaced on Exophase, a site that specializes in trophy and achievement tracking.
Persona 6 and Persona 4 Steam achievements surface
Steam Achievement lists for Persona 6 and Persona 4 Revival have surfaced on Exophase, a site that specializes in trophy and achievement tracking.
Persona 6 and Persona 4 Revival Steam achievements surface [Update: More games leaked]
Steam Achievement lists for Persona 6 and Persona 4 Revival have surfaced on Exophase, a site that specializes in trophy and achievement tracking.
Dodgers on Deck: Wednesday, September 9 vs. Reds
The Dodgers close out their nine-game homestand on Wednesday night, with one more game against the Cincinnati Reds. Yoshinobu Yamamoto starts Wednesday, and like Tuesday starter Tarik Skubal is set up to face the Reds twice in a row, as these two teams meet up again next week for four games at Great American Ball […]
Pappas, Sununu sweep to victory in U.S. Senate primaries
Pappas, a four-term Democratic congressman, will face off against Republican and former U.S. Senator John E. Sununu.
Pappas, Sununu sweep to victory in U.S. Senate primaries
Pappas, a moderate Democrat and current Congressman in the 1st Congressional District, will face off against Republican and former U.S. Senator John E. Sununu.
Man sentenced after breaking child's fingers while working for health facility
A man is avoiding jail time after breaking a child's fingers in 2025 and not reporting the injuries while working for KidsPeace, officials said.
California’s next governor will face destabilizing surge in uninsured
Should Xavier Becerra cruise to victory in the California governor's race in November, as polling suggests, he will face what may be the steepest decline in health insurance coverage in a...
Chris Pappas Defeats Progressive Challenger in New Hampshire Senate Primary
Mr. Pappas, a moderate Democrat who has served four terms in the House, will face former Senator John E. Sununu, the Republican nominee, in November.
Much-needed mental health resources to open soon in Anchorage
A pair of crisis stabilization centers are under construction in the University-Medical District and an intensive case management facility is planned for downtown
Making Sense of Phoenix Suns' Biggest Storyline This Season
As roster shifts trade elite shooting for raw athleticism, Phoenix faces a high-stakes gamble on Miles Bridges to elevate their ceiling amidst looming threats of early-season regression.
Rep. Chris Pappas will face former Sen. John E. Sununu in New Hampshire Senate race, CNN projects
Democratic Rep. Chris Pappas will face Republican former Sen. John E. Sununu in the race for New Hampshire’s open Senate seat, CNN’s Decision Desk projects.
What Will Life Science Orgs Do When The AI Bill Comes Through?
AI is transforming clinical development, but what happens when usage costs spike? Jon Newton explains how to govern it before the bill lands.
Gov. Tina Kotek says she now supports a data center moratorium
The Oregon governor is escalating her stance on the facilities as they emerge as a political hot potato.
Bryan Health receives $750,000 grant to create Rural Family Medicine Residency program
The grant will provide funding over three years to support accreditation planning, curriculum development, faculty recruitment, resident recruitment and other activities necessary to establish a new program.
$30 million maintenance bill looms over Roanoke’s aging entertainment venue
A laundry list of decay, broken equipment, and failing infrastructure inside the aging building has left the city facing an estimated maintenance and repair bill of at least $30 million
Should political candidates have more security?
COLUMBUS, Ohio (WCMH) — The man accused of trying to attack Ohio gubernatorial candidate Dr. Amy Acton appeared in court for the first time Tuesday. Patrick Havas, 38 of Canfield, faces assau…
'Practical Magic 2' is charming but cursed by repetition
The Owens sisters are as bewitching as ever – multiple generations of them, in fact – in “Practical Magic 2,” even if the sequel might only truly cast a spell
Detroit businesses face costly repairs after tornado tears through east side
University of Chicago health care workers push for passage of RIFL Act targeting gun manufacturers
Putin and Trump discuss Ukraine in 'extremely frank' call
Washington has been pushing for fresh face-to-face talks between Moscow and Kyiv to reach a peace deal
Faculty Focus: Chris Erickson, College of Business
Chris Erickson has spent 40 years at NMSU as an economics professor, researcher and mentor. Erickson, a professor in the Department of Economics, Applied Statistics and International Business in...
Sonoma County delays opening of El Verano behavioral health facility for second time this year
The facility in El Verano — which would bring services closer and expand homelessness services to Sonoma Valley residents and which county officials had called “a big win for the Valley” — was originally expected to open in June.
Is Davion Mitchell the Miami Heat's Biggest X-Factor?
Gabe Vincent highlights Davion Mitchell’s offensive impact, but Pelle Larsson could prove even more vital to the Miami Heat's championship aspirations.
Survey: Will Michigan cover the spread vs Oklahoma?
Will Michigan cover the spread against Oklahoma? Vote in this edition of SB Nation Reacts.
Fact-checking Trump's stories about his own 9/11 response
President Donald Trump recounted his response to the Sept. 11, 2001, attacks in an interview and event leading up to the 25th anniversary this week, repeating statements that lack evidence about aiding in the recovery.
Ticket package secures your place for the match against Santos
Galo will face three major home challenges in September, including the decisive Copa Sudamericana quarterfinal match against Santos, and the Massa can now secure their place at Arena MRV with a specia...
Shutterstock Appoints Three Accomplished Business Leaders to Board of Directors
/PRNewswire/ -- Shutterstock, Inc. (NYSE: SSTK), a family of brands delivering scalable creative and GenAI solutions to help customers fuel great work, today...
Catch 22: Californians can't afford health insurance but face fines if they drop it
For one Californian, the state subsidy contributed $1 a month to her $600 premium. She considered dropping coverage but faced a $1,600 penalty.
UND again named among region’s best places to work
Prairie Business recognition reflects workplace culture created by UND faculty and staff.
Dunlap highlights high home heating oil prices in Maine
Dunlap, who faces former Republican Gov. Paul LePage on the Nov. 3 ballot, said Maine continues to be the state where more people rely on home heating oil than any other.
Exclusive: Two of gaming’s biggest names are making a big investment in gaming’s future
The first thing to know about the Nova Games Foundation is that it isn’t about The Game Awards. And it’s not about PlayStation. The ambitious new grant program is the brainchild of Geoff Keighley and Mark Cerny. Keighley is the host of The Game Awards, Summer Game Fest and Opening Night Live. Cerny is a game designer of some 45 years and the lead architect for the PlayStation 4 and 5. But this new thing, which they’re revealing through Game File, isn’t about their day jobs. It’s an unaffiliated, standalone philanthropic project. It’s a bet on the artistic future of video games and a way, they tell me, to give back. “I’m nearing the end of my career,” Cerny recently told me over email. “I’m not done yet, but paying it forward—in the best way possible—is very much on my mind these days,” The Nova Games Foundation is a university-affiliated fellowship program, intended to offer six-figure grants to 20 young game designers each year, potentially for decades to come. It will offer no-strings-attached funding along with mentorship from games industry leaders, a combination intended to aid the development of groundbreaking new games, Cerny and Keighley told me. Nova will begin accepting applications in December, from class of 2026 and 2027 students from 13 affiliated gaming programs at universities in eight countries. The schools working with Nova include the New York University and the University of Southern California in the U.S., along with Abertay University in Scotland, Cnam-Enjmin in France, TH Köln in Germany, and the Royal Melbourne Institute of Technology in Australia, Cerny and Keighley said. The plan: $100,000 per recipient, with about a quarter of Nova fellows eligible for up to $500,000 more for projects that are shaping up particularly well. Payments will be delivered based on development milestones, and recipients will own their games. Nova will help promote the work, and developers will be free to pursue the publishers and platforms of their choice. Nova can help introduce fellows to publishers, but won’t take a cut. “I’ve always wanted to give back, but given my role in the industry, I’ve never felt it appropriate to commercially invest in games,” Keighley told Game File. “I’ve never owned stock in a game company or taken a financial stake in a game. Nova is philanthropy: we aren’t taking equity or looking to recoup the grants. The return we’re hoping for is creative—helping new voices make games and find their footing. “Mark and I have each made multi-million-dollar donations to establish the foundation, and we intend to keep contributing. We hope others will join us.” Cerny and Keighley have already hired an executive director, John Maconga, and a head of grants, recent Game Developers Conference director Ashley Corrigan, to help launch the effort. They’re working to recruit game industry leaders to join the effort. Keighley says “dozens of leading game directors have already expressed interest in contributing their time.” To name one, they’ve already gotten Josef Fares, lead designer from It Takes Two and Spit Fiction studio Hazelight on board with a donation and pledge to help out. “I’m proud to support Nova because it gives the next generation of creators the freedom to explore their creativity and hopefully bring their unique visions to life,” Fares told Game File. A plan forged from a friendship Keighley and Cerny have known each other a long time. It’s been so long, Cerny isn’t even sure exactly when they met. “We travel in much the same circles and I’m sure first intersected in the 90s or early 2000s,“ Cerny said. Keighley thinks it might have been during his stint writing a column about the mid-’90s console 3DO for a gaming magazine while Cerny was working on games with Crystal Dynamics or on Way of the Warrior with Naughty Dog. They became genuine friends about a 10 years ago, Keighley said, as they bonded over a shared love of games and a hope to improve the industry. “About a decade ago, we started having dinner a few times a year in LA,” Keighley said. “Just to catch up on life and the industry. Those conversations continued over Zoom during COVID. Nova grew out of that friendship and a question we kept coming back to: ‘What could we do to help the next generation of game directors get started?’” Keighley credits Cerny with the idea to figure out a way to put their money and time back into the industry. At one of those dinners, Keighley proposed the idea of a fellowship program. He’d recalled applying for a Rhodes Scholarship when he was younger. “Spoiler: I didn’t get it,” he said. He’d admired the MacArthur Foundation’s so-called “genius grants.” He liked these kinds of programs that recognized people’s talents and gave them the financial boost and the freedom to realize their potential. With Cerny, he had pondered what a game industry version of that could be. Keighley liked the idea of centering the fellowship on students, drawing inspiration from the accomplishments of Jenova Chen, the USC game design graduate who went on to lead the creation of gently moving, ambitious games such as Flower and Journey. Keighley also thought it could be useful to help promising graduates bridge the transition from student to professional. “Joining an established studio isn’t always possible—especially in today’s market—and even then, it isn’t the right path for everyone,” Keighley said. A fellowship, he realized, could give “graduates the time, resources and guidance to pursue a game of their own and not worry about the commercial viability.” As the idea took shape, Cerny also saw an opportunity to enable more games of a certain type: “The target with the grants is games as an artistic medium,” Cerny told me. “We like to say games with ‘artistic, literary and societal value.’” He added: “I’m a pretty big gamer myself, though I tend to gravitate towards the smaller and more unique or artistic titles, games like Neva, Abzu, Gorogoa, Stray or Outer Wilds. I was just playing and Roger on a flight to Japan, and was getting misty eyed to a degree that I was concerned that a flight attendant would ask me if I was OK. “So one fun benefit here is the games that will come out of the Nova Games Foundation – I can’t wait to play them myself.” Cerny believes it will also be useful for Nova fellows to hone their craft and team leadership skills. “We are looking for the next generation of visionaries,” he said. “The trick is that they will also need to have the executive function necessary to drive a small project to completion.” Game File is a reader-supported publication. To receive new posts and support my reporting, please consider becoming a free or paid subscriber. Subscribe Going big with this Keighley and Cerny may have started Nova and may be the ones primarily backing it right now, but they’re dreaming of something that goes beyond them. “Mark and I may have helped get it started, but one of our measures of success is that Nova grows into something the entire games industry feels a sense of ownership in,” Keighley said. “Our ambition is to build a lasting endowment supported by people and companies across the industry, and an equally broad community of creators willing to give their time and experience to the next generation.” The industry has a lot of knowledge that it can pass to the next generation, Keighley said: “Nova can hopefully become a way to connect that generosity with talented young creators at the moment when it can make the biggest difference.” Cerny, who told me he believes Nova can mature “over the next 10 or 20 years,” sees an opportunity to give generations of game makers momentum. “The industry has changed immeasurably since I started in games in 1982,” he said. “These graduates have talent, training and tools that outclass what we had back in the day by an astonishing amount. But they face a tough road ahead getting traction in the industry, and many could benefit from our support. We want to be there to give it to them.” “There’s a personal side to this, too,” Keighley said. “I don’t have children, and I’ve spent a lot of time thinking about what I can do for future generations. Games have been my entire career. I’ve been incredibly fortunate, and helping someone else build a life in this industry feels like a meaningful way to give back.” Cerny’s oeuvre dates back to Marble Madness and Sonic the Hedgehog 2. He has stood on stage multiple times to reveal the future of PlayStation hardware. He’s been an executive producer for a string of modern PlayStation classics such as The Last Guardian and Marvel’s Spider-Man. Nevertheless, of Nova, he said, “It’s certainly not like anything I’ve done before.” Nova Foundation applications will be due in December and the first wave of fellows will be announced in March 2027. A full list of participating universities and steps students and recent graduates can take to apply to become a Nova Fellow is forthcoming.
Santa Cruz to build a new type of mental health care center for youth
Serenity Smith, who lived at a residential treatment facility in Santa Cruz in 2024, drives to work in Aptos on Monday, Aug. 31. (Amaya Edwards — Santa Cruz Local/CatchLight Local) Located at: 5300 Soquel Ave., Santa Cruz, CA 95062. Call (831)540-4141. Behavioral Health Resources
Funding cuts are forcing dozens of health clinics in Sudan to close, aid groups warn
CAIRO (AP) — An additional three dozen health facilities serving more than 400,000 people in Sudan are closing this year due to global aid cuts, worsening a dire humanitarian situation in a country torn by more than three years of war, aid groups said Tuesday.
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Women immigrant-owned businesses featured at massive market at HER Tel Aviv festival
“We really want to show the diversity and the connection and the love for Israel,” HER Tel Aviv founder and CEO Sivan Hadari said.
Study finds social, financial, and healthcare factors shape resilience in adults with sickle cell disease
A new study explores how individual and community health experiences of adults with Sickle Cell Disease (SCD) shape resilience — the capacity to adapt to adversity.
Padres Hope To Have Finishing Kick For Homestretch
The San Diego Padres are facing a short season at this point, and no one knows how they'll handle the homestretch.
Dallas mayor sounds alarm on the 'grave threat' facing America's cities
Dallas Mayor Eric Johnson warns a socialist movement threatens U.S. cities and the economy, touting his city's financial services growth and free markets.
Doctors Without Borders warns that funding cuts are forcing health clinics to close
Aid groups say three dozen health facilities in Sudan are closing this year due to global aid cuts. This worsens an already dire humanitarian situation in a country torn by more than three years of war.
Funding cuts are forcing dozens of health clinics in Sudan to close, aid groups warn
Aid groups say three dozen health facilities in Sudan are closing this year due to global aid cuts
Parents of San Diego mosque gunman say a mental health facility failed to heed FBI warning
LOS ANGELES (AP) — The mother of Caleb Vazquez alleges in her lawsuit that Park Mental Health Treatment of San Diego failed to intervene despite signs that her 18-year-old son posed an imminent threat to himself and others.
Stand Up for Science Demands Congress Stop Transfer of National Institutes of Health Research Funds to
New petition urges Congress to stop an interagency agreement that would allow health research money to fund War Department’s unspecified priorities.
Atlanta Braves Announce Pitcher News Before Rays Series
After splitting their four-game series with the Philadelphia Phillies, the Atlanta Braves remain 4.0 games up in the NL East. No off day for Atlanta, as they head home to face the AL East-leading Tampa Bay Rays in a new series this week. It’s another big litmus test for the Braves, as the series’ on […] The post Atlanta Braves Announce Pitcher News Before Rays Series appeared first on HEAVY.
Youth with CF on approved treatment still face mental health issues
Youth with cystic fibrosis continue to experience mental and behavioral health concerns despite treatment with Trikafta, according to a study.
SKY BLUE CINEMATIX - ENTERTAINMENT - BRAND INTEGRATION : Two Films. One Global Partnership.
Sky Blue Cinematix appointed exclusive worldwide brand-integration partner for two new features from Tested Films.London, UK, Sept. 08, 2026 (GLOBE NEWSWIRE) -- Sky Blue Cinematix, the entertainment and brand-integration division of Sky Blue Media Group, today announced its appointment as the exclusive global brand-integration partner for two upcoming feature films from Tested Films: the action thriller Habeas Corpus and the neo-noir romantic mystery Blurred. Sky Blue Cinematix appointed exclusi
NYC releases 170,000 pages of long-sought 9/11 health, air quality records
New York City opened a public portal containing 170,000 pages of 9/11 records sought for years by first responders, survivors and families concerned about Ground Zero health risks
From California to the Moon: Daniel Rivers and Sally Ashton Explore the Intersections of Art and Science NewsCenter | SJSU
Two new books from San José State faculty take on that question through explorations of environmental justice, space, California history and the possibilities of more just futures.
Monday Morning Minnesota: The “Slowly Drifting Away” Edition
So close, and yet so far.
In 2018, scientists seeded clouds over China's Muz Taw Glacier to make snow; the brighter surface was followed by 14% to 17% less ice loss in a preliminary experiment
Researchers in China have tried to make artificial snow over China’s Muz Taw Glacier to slow its melting. The experiment conducted in 2018 involved seeding clouds with silver iodide, which helped trigger snowfall over the glacier.
NYC releases 170,000 pages of long-sought 9/11 health, air quality records
New York City opened a public portal containing 170,000 pages of 9/11 records sought for years by first responders, survivors and families concerned about Ground Zero health risks
Small business optimism slips in August as sales, inflation concerns persist
Small business optimism declined in August as owners faced weaker sales, inflation and hiring challenges, according to NFIB’s latest survey.
Dan Campbell Gives Kerby Joseph Update Ahead of Week 1
Kerby Joseph has returned to the Detroit Lions facility as he continues recovering from the knee injury that ended his 2025 season.
AI Factories Turn Infrastructure Into a Business Advantage
AI factories are an industry must as enterprises move from experimentation to scaled agentic workloads, says Penguin Solutions’ Aaron Johnson.
Business internship presentations connect classroom learning to career readiness
Nineteen Penn State Lehigh Valley business students concluded their required summer internships by presenting what they learned to faculty and staff evaluators. The presentations culminated a semester-long process designed to help students connect their academic preparation, workplace experiences and career-readiness skills.
Padres should be 'excited' about September call-up Ethan Salas
Salas can help the Padres clinch a postseason berth.
Meta Removes Iran-Linked Network That Faked American Personas to Sway US Political Debate
The Combat Antisemitism Movement (CAM) welcomes Meta’s recent removal of an Iranian regime-linked network that disguised its origins while seeking to influence American political discourse. Meta disclosed the takedown on Aug. 27 in its H2 2026 Adversarial Threat Report. The network consisted of four Facebook accounts and 31 Instagram accounts linked to actors based in […]
Months of Pain, Delayed Care: An Asylum Seeker’s Health Crisis in ICE Custody
Mother held at San Diego immigration facility says months of delayed and inadequate medical care have left her with serious kidney infection and worsening pain.
Hidden camera found in bathroom of Volusia County pet daycare business, owner arrested, deputies say
The owner of a pet daycare and boarding facility in Volusia County has been arrested after a hidden camera was found in the facility's bathroom, according to the Volusia County Sheriff's Office.
HHS Awards Over $225 Million to Improve Head Start Nutrition, Facilities and Services
The U.S. Department of Health and Human Services, through the Administration for Children and Families, announced over $225 million in Head Start supplemental awards.
Live Results: Rhode Island midterm primaries
Rhode Island Gov. Dan McKee faces a tough Democratic primary challenge Wednesday in his bid for a second full term.
Celebrating 19 Years of Impact from One Iconic Desk
For nearly two decades, Administrative Assistant Carolina Rodriguez has been one of the first faces people see and one they remember at South Texas College’s (STC) Mid-Valley Campus. Long before titles or job descriptions, she became something harder to define but easy to feel: a constant presence, a listening ear and the heart of the campus.
Two Factors Dictating Orlando Magic's Success
The Orlando Magic have to do a lot right to reach their desired heights next season.
North Dakota Today - North Dakota Small Business Development Center
recurring recording of North Dakota Today on KVLY
Miami Heat's Davion Mitchell Eyeing the Most Improved Player Award
A cryptic beach message signals high ambitions for the Miami Heat’s starting point guard. Surrounded by superstars, Davion Mitchell aims to leverage his facilitating role into a career-defining season.
'Practical Magic 2' brings back the magic and the mess
The Owens sisters are as bewitching as ever – multiple generations of them, in fact – in “Practical Magic 2,” even if the sequel might only truly cast a spell
Norman Rock Creek Entertainment District faces lawsuit over tax increment financing
Norman's Rock Creek Entertainment District is a $1 billion project set to open in 2028, including a multipurpose performance venue, restaurants, retail space, office development, a hotel, and multiple housing options.
College Football Has Adopted the Western Michigan Broncos
The country has picked a side after Michigan's one-second Hail Mary, and it isn't the Wolverines. #WMU
Hidden camera found inside bathroom leads to arrest of Volusia County man, deputies say
He faces 10 counts of digital voyeurism and 11 counts of video voyeurism of a child.
The Good, the Bad, the Ugly: Week 1
Through week one, we are already starting to have some clarity as to who the top teams in the Group of Six are. North Dakota State has looked dominant through two games, Boise State almost pulled off a massive upset against a National Championship contender, and the Air Force defense looks improved. It is certainly […]
Rock Creek Entertainment District in Norman faces another legal battle
A judge will hear arguments on Tuesday as the legal battle over the $1.1 billion Rock Creek Entertainment District in Norman heads back to court.
AZ's R&D chief Barr touts internal 'science success story' after IL-33 antibody's stellar showing in COPD
With a detailed data drop that AstraZeneca’s R&D chief described as an internal “science success story,” the British Big Pharma has secured an FDA priority review for what it believes could become a flagship biologic in chronic obstructive pulmonary disease (COPD). In detailed results from the late-stage Oberon and Titania trials—first teased in March and detailed in full at the European Respiratory Society Congress in Barcelona this week—the drugmaker laid out the extent of its IL-33 inhibitor’s potential to reduce moderate and severe exacerbations in a wide range of COPD patients still struggling with those “lung attacks,” as AstraZeneca’s Sharon Barr, Ph.D., called them, despite using standard-care inhaled therapy. In the headline results, a 300 mg dose of tozorakimab given once every four weeks curbed those moderate and severe exacerbations in the studies’ primary population of former smokers by 29% in the Oberon study and 34% in Titania. In the overall population of both current and former smokers, these reductions were 30% and 29%, respectively, versus placebo and inhaled standard of care. The benefits also extended to clinically meaningful exacerbation reductions in all prespecified patient subgroups and specifically turned up promising signals in patients across a range of blood eosinophil counts, with Barr telling Fierce that “it’s the details that make this even more exciting than the high-level results that we’ve already shared.” In fact, during AZ’s tozorakimab poster presentation at the ERS 2026 Congress this past weekend, attendees were so enamored by the data that event organizers had to encourage people to clear the room and look at the other presentations on offer, Barr said in an interview. “I think it really speaks to the fact that there is a lot of buzz around these data because the entire respiratory community has been so desperate for new therapies for these patients,” she explained. The respiratory disease continues to represent a “staggering unmet medical need,” Barr said, highlighting the COPD exacerbations that the Oberon and Titania studies homed in on, which she added carry a greater mortality risk than a heart attack. “When a patient has a severe exacerbation, only about half of them are still alive within three and a half years,” she pointed out. As for tozorakimab specifically, Barr christened the molecule “an AstraZeneca science success story,” harkening several years back to the point at which researchers began to explore IL-33 as a driver of respiratory disease, and COPD in particular. At the same time, “there was still so much that wasn’t understood,” she admitted, highlighting the insight that IL-33 signals through both ST2 and EGFR through the RAGE pathway, a discovery Barr attributed to AstraZeneca's own scientists. Understanding the need to tackle both pathways in COPD—and aware of competitor candidates in the hopper, including one that bound ST2—the company ultimately had to make some “courageous decisions,” Barr said. These included taking a prior COPD molecule offline and going back to the drawing board to reinvent its potential IL-33 label “to make sure that we had a molecule that could block signaling through both arms of the pathway, through both the reduced form and the oxidized form, knowing that we wouldn’t be first, but striving to be best.” “When we put [tozorakimab] into the clinic, we firmly believed that we had a differentiated molecule, and we saw the other molecules blocking just ST2 or partially blocking IL-33, unable to deliver two positive pivotal studies in COPD,” Barr explained. “We kept marching forward because we believed our molecule was differentiated, and now I think we have the clinical validation that supports that.” Ultimately, AstraZeneca finds itself on much better footing these days when it comes to potential biologic rivals to tozorakimab in COPD. Sanofi and Regeneron’s Dupixent, for instance, is approved to treat COPD exacerbations in patients with high eosinophil counts, but not low ones. Meanwhile, the future has become cloudier for other next-gen IL-33 candidates from Sanofi and Regeneron, as well as Roche, which have suffered trial flops in recent years. One other potential ingredient for AstraZeneca’s success in its duo of studies was that the company was “ambitious in the trial design, willing to look at an all-comers population,” Barr said, “and willing to enroll the most severe patients.” Prior studies for would-be biologics rivals in COPD “avoided enrolling” those patients, she pointed out. She also highlighted the Big Pharma’s painstaking design of exacerbations in its trial, which “gave us a very rigorous readout,” and pointed to “the extra effort and investment” the company put in to understand the effect of mucus plugs in patients. Barr described mucus production as a “key feature in disease diversity,” noting that mucus plugs—obstructing clumps of mucus that block patients’ airways—are associated with worse outcomes in COPD. In its data announcement, AstraZeneca noted that an integrated analysis of Oberon and Titania found tozorakimab “demonstrated a reduction in patients’ mucus plug score,” with the pharma claiming its biologic is the first to deliver such results in a broad COPD population. “So being able to reduce those mucus plugs, we expect, is an important part of driving benefit for patients who are living with COPD,” Barr said. Again touching on the breadth of the study populations, Barr added that tozorakimab “worked across all eosinophil levels in both current and former smokers across all levels of lung function,” which she suggested “really simplifies decision-making for clinicians, and it allows them to offer therapy to the broadest possible patient population.” In the highest patient eosinophil count group, tozorakimab helped chart a 43% reduction in exacerbation risk, which Barr stressed were “unprecedented data.” In the mid-level group, AZ’s drug delivered a 23% reduction and, in the lowest group, a 34% reduction in eosinophils, which Barr said suggests efficacy “in all patient subgroups.” As for AZ’s recent guidance upgrade on the medicine’s sales opportunity, the lift from a $3 billion to $5 billion range to $5 billion plus was informed by multiple factors, Barr said, including the fact that “in 2024, there were multiple competitors, and there aren’t anymore.” Additionally, “we know that this is a massive unmet medical need, and this is a really incredible set of data that we think will be very convincing to the clinical community,” Barr said. Looking ahead to a potential evolution of the COPD treatment landscape, Barr noted that most patients start treatment in the community with an option like a triple therapy, and for them, having an option like AstraZeneca’s inhaler Breztri will remain a “really important part” of that journey. But of the patients uncontrolled on triple therapy, which Barr described as “about half of them today,” just a “small fraction” are currently eligible for biologic therapy, which she emphasized AstraZeneca is working to change. Understanding that COPD is not a “one-size-fits-all” disease, AstraZeneca is also looking at its antibody drug Tezspire for patients with T2-driven disease, and the company continues to think about new mechanisms for tackling COPD through both systemic and inhaled drugs, Barr said.
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