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DUCK DYNASTY Stars Launch Entertainment Company, a ‘Safe Space for Families’
DUCK DYNASTY’s Willie and Korie Robertson just launched a new entertainment company that’s safe for the whole family.
Integrating AI as a Human-Guided Tool in Translational Science
Peter Tummino of Nimbus Therapeutics explains how drug discovery and development experts can apply AI across targeted workflows with intention and creativity.
Cloud Computing for Life Science Research: AWS, Google Cloud, and HPC—Which Do You Need?
A practical, no-hype comparison of cloud computing for life science research: when AWS, Google Cloud, or institutional HPC actually fits. Explore the guide.
Lenovo announces new C700 handheld with cloud gaming in mind, set to launch next month
The new device is called the Lenovo Legion C700, and Lenovo has officially teased its launch with the message “See you in August."
MINNEAPOLIMEDIA PRESENTS | This Weekend in the Twin Cities – Entertainment Guide: July 10 ~ July 12, 2026 Edition
Twin Cities weekend features major festivals, concerts, family events, Twins baseball, art, markets and nightlife across Minneapolis and Saint Paul.
Managing water with local wisdom and science
Across a narrow watershed in Asakura, a rural city in Fukuoka Prefecture, centuries-old stone channels still guide water through fields and into the river below. Today, those same systems are the focus of researchers at Kyushu ...
Managing water with local wisdom and science
Across a narrow watershed in Asakura, a rural city in Fukuoka Prefecture, centuries-old stone channels still guide water through fields and into the river below. Today, those same systems are the focus ...
From Moana to Suki Waterhouse: your complete entertainment guide to the week ahead
Dwayne Johnson and Catherine Laga’aia star in the latest Disney animation to get the live-action treatment, and the model-actor-singer proffers more of her signature lush soft rock
MINNEAPOLIMEDIA PRESENTS | This Weekend in the Twin Cities – Entertainment Guide: July 10 ~ July 12, 2026 Edition
Twin Cities come alive with major festivals, concerts, family fun, sports, markets and nightlife. Discover MinneapoliMedia's top picks for July 10–12.
Navigating the Business Tax Account: Summer 2026 Enhancements, Access Protocols, and Strategic Implications for Practitioners
Internal Revenue Service. Summer 2026 Expanded Features for BTA. Fact Sheet FS-2026-11. July 2026. Retrieved from IRS.gov Newsroom. Internal Revenue Service. Business Tax Account. Official Platform Documentation & Eligibility Guide. Last Updated: July 9, 2026. Retrieved from IRS.
From Vision to Joint Health: A Full-Body Guide to Staying Well
When you think of wellness, what comes to mind? Is it eating healthy? Exercising regularly? Or going to the doctor when you’re feeling under the weather? Wellness can mean many different things depending on who you ask, but to the healthcare providers at The Baton Rouge Clinic and Affinity Health Group, true wellness comes from […]
PlayStation is getting community noted for its “poor digital ecosystem” as fans continue to ask about discs
As gamers continue to complain about PlayStation on social media, the company's official X account is being flooded with community notes.
IS YOUR BUSINESS SIGNAGE ADA COMPLIANT? A PLAIN-LANGUAGE GUIDE FROM FASTSIGNS
Many business owners assume their signage is compliant simply because it looks professional. In reality, the Americans with Disabilities Act (ADA) sets specific, measurable standards for text height, contrast, braille placement and mounting location, and that's why FASTSIGNS®, a global leader in custom sign and visual graphics solutions, has published a plain-language guide so business owners can quickly check whether their existing signage meets these requirements.
Scientific Merit, Not Political Priorities, Should Guide Research Stewardship
The proposed OMB changes to research funding threaten US science. Researchers must stand up for and share the value of science to society.
Parkview hires former Community Health exec to help guide central Indiana expansion
In his new job, Dr. Ram Yeletti will focus on expanding Parkview’s specialty care services and physician network in its new markets.
Scientists discover how roots steer clear of rotting plants
Decaying matter shapes life in soil, but it can also create hostile zones for growing roots. Professor and ERC grantee Jiří Friml of the Institute of Science and Technology Austria (ISTA) and international collaborators have now identified “saprotropism,” a root response that guides plants away from decaying plant-derived matter, but not animal-derived decay. The study, led by Yuzhou Zhang, Professor at Northwest A&F University in China and published in Science, reveals how roots adapt their growth direction by sensing local pH gradients around rot.
HHSC Names New Chief Counsel, Texas Medicaid Director | Texas Health and Human Services
HHSC names key leadership appointments to lead the agency’s Chief Counsel Division, and guide Texas Medicaid and CHIP Services.
Road of Legends Day 5: All Five-Star Raids, Primal Raids , Bonuses and Guides
Road of Legends is a stacked week of Legendary raids, Mega Raids, event bonuses, Special Backgrounds, Adventure Effects, and a new GO Pass. Running from July 6, 2026, at 12:01 a.m. to July 10, 2026, at 11:59 p.m. local time, Road of Legends is a final prep event before GO Fest Global weekend. Trainers will […]
'Preaching as resistance': Dem minister behind Satanist wedding now linked to anti-Trump sermon guide
Sarah Trone Garriott authored a chapter in a 2018 "resistance preaching" guide that urged faith leaders to combat Trump and MAGA from the pulpit.
Samsung Galaxy Watch 9 and Galaxy Watch Ultra 2 price and release date leaked ahead of official announcement
A new leak reveals the release date and price for the upcoming Galaxy Watch 9 and Galaxy Watch Ultra 2, set to be revealed this month.
Machine Learning for Life Scientists: A Practical Methods Guide
Learn practical machine learning methods for life science research, covering supervised learning, model evaluation, and how to choose the right approach.
Warm here, cold there reception greets go-live of ‘Make Hospital Food Healthier’
HHS reiterates: Consistent with the Code of Federal Regulations and CMS guidance, hospitals “should provide inpatient meals that align with the federal government’s Dietary Guidelines for Americans.”
LeBron James Might Be Making the Smartest Move of His Career by Walking Away From the Lakers
As your business grows, let your values, not just money, guide the decisions that shape your work, leadership, and life.
Pixel Watch 5 price increase expected as configs and release date leaked ahead of Made by Google event
Google's annual Made by Google event is confirmed for next month, and the new Pixel Watch 5 has been leaked ahead of the presentation.
Teton Science School, Indian Springs Ranch to get county funding to design tunnel
Teton County commissioners reserved $65,000 in their budget to take early steps to ease harrowing left turns out of the Teton Science School and gated Indian Springs Ranch subdivision on to Highway 22.
Road of Legends Day 3: All Five-Star Raids, Mega Gardevoir, Bonuses and Guides
Road of Legends is a stacked week of Legendary raids, Mega Raids, event bonuses, Special Backgrounds, Adventure Effects, and a new GO Pass. Running from July 6, 2026, at 12:01 a.m. to July 10, 2026, at 11:59 p.m. local time, Road of Legends is a final prep event before GO Fest Global weekend. Trainers will […]
"Pitch Black" Set Guide: Full Set List, Product Lineup, Store...
We now have the full English set list for Pitch Black starring Mega Darkrai ex! As posted before, it will release on July 17th as our fifth English Mega
How data guides Ochsner Health’s physician well-being work
Smart survey design helps the Gulf South health system track well-being, cut physician burnout and turn feedback into action.
Community Engagement in the Science and Study of Gun Violence
Learn how a new guide helps researchers partner with communities most affected by gun violence to produce more equitable, community-engaged research.
A toxicologist's guide to reducing your exposure to everyday chemicals
There’s no such thing as a "chemical-free" life, but some simple steps can help you minimize exposures to daily chemicals.
From Michelle Obama To Cardi B, Keke & Brandy & Monica, This Is Your Guide To Celebs At Essence Fest
From Michelle Obama to Cardi B, Keke Palmer, Brandy and Monica, and an Aaliyah Tribute, here's a recap of the celebs who showed up to Essence Fest to inspire, entertain, and celebrate.
Researchers Develop AI Test to Predict Recurrence of Breast Cancer
Breakthrough offers potential for faster, less costly predictions to help guide treatment
AI and Data Science in Life Science Research: A Practical Guide for Scientists
Discover how AI and data science are reshaping life science research, covering genomics, imaging, ML methods, data management, and LLM tools for scientists.
She navigated the US alone. Now, a UNT Health Fort Worth strategist guides others
Annabel Luna-Smith turned her own immigrant experience from Venezuela into work connecting residents to care and support.
Claude Fable 5 Helped Port A Native Version Of Command & Conquer: Generals Zero Hour To iPhone & iPad, Complete With Touch Controls And More
A step-by-step guide reveals how Command & Conquer: Generals Zero Hour was natively ported to iPhone and iPad, with the help of Claude Fable 5
Roob's Eagles Observations: Bryce Huff's hilariously misguided memory of 2024
Why Jeff Lurie is the best owner in Philadelphia sports history, Bryce blaming everyone but himself and more in Roob's Eagles Observations.
Former CIA official left Google to start AI business: Career advice
Candice Bryant spent nearly 16 years at the CIA before joining Google. She shares why she left Big Tech and the philosophy that's guided her career.
China Issues Guide for Registering International Science Groups
China issued guidance for establishing international scientific organizations in the country, setting out registration requirements for nonprofit groups focused on scientific cooperation, exchange and governance.
From Madonna to Minions & Monsters: your complete entertainment guide to the week ahead
The begoggled yellow munchkins are indulging in a spot of time travel, and the queen of pop returns with a new album of pristine dancefloor bangers
Who's attending Taylor Swift and Travis Kelce's wedding: A guide to the guest list
Taylor Swift and Travis Kelce's wedding at Madison Square Garden is shaping up to be a star-studded extravaganza. Here's your guide to the celebrities on the guest list.
Long Reads for the Long Weekend
(Welcome to the Entertainment Strategy Guy, a newsletter on the entertainment industry and business strategy. I write a weekly Streaming Ratings Report and a bi-weekly strategy column, along with occasional deep dives into other topics, like today’s article. Please subscribe.) Happy Fourth of July weekend! As has been a tradition of mine going back to the beginning of the EntStrategyGuy website, I’m sharing my favorite long reads of the last year, like I did in 2019, 2020, 2021, 2024, and 2025. Let’s dive right in! Subscribe “Different Prices for the Same Ride: How Uber and Lyft Use AI to Get More Money Out of You“ by Derek Kravitz in Consumer Reports I don’t think surveillance pricing, like the kind described in this brilliant Consumer Reports article, is long for the world—it’s toxically unpopular—but we’ll see if either party takes on this issue. If I ran a political party focused on affordability, I would focus on a few pro-consumer and pro-market policies: Banning non-compete agreements. Ending surveillance pricing Eliminating junk fees (read more here...) Ensuring “right to repair” for consumer (and military!) products Capping excessive app store fees Stopping digital/algorithmic price-fixing tools. Preventing automatic subscription price increases. And more. If you want to fight inflation, there are a lot of great ways to do it quickly. Speaking of higher prices... “Secret Documents Show Pepsi and Walmart Colluded to Raise Food Prices Across the Economy“ by Matt Stoller in BIG Again, I think a political party should focus on lowering prices for consumers. And deals like this—Walmart making a deal/forcing Pepsi to offer the lowest prices at its stores and nowhere else—hypothetically lower prices at Walmart...but raise them everywhere else. “15 DUIs, still driving: California’s failure to take repeat drunk drivers off the road“ by Robert Lewis and Lauren Hepler in CalMatters CalMatters does terrific reporting in California, something the Golden State desperately needs more of, and this article is a great example of that. “PugLips: The next insanely popular thing you’ve never heard of…” by Simon Carless in Game Discover Co I thought that this parody article (and yes, it’s a parody, but I was definitely unsure at first) was hilarious and totally nailed how much tech/business journalism feels these days. Actually, three of my favorite articles this year were on hype in the video game industry, including Georg Zoller’s “The Video Game Industries Very Dark Night”—which I linked to recently and wrote a follow-up here—and Owen Mahoney’s “Derek Zoolander, Videogame Exec”. In particular, I like Mahoney’s focus on user experience as a guide to what trends will actually grab hold of customers. “The Matrix Lies“ by Evan Shapiro in Media War & Peace Evan Shapiro’s first person account of his experience with AI was hilarious. I think LLMs capabilities have significantly grown from last summer, and yet...my editor/researcher just had an abysmal experience using an LLM to do a quite basic task (which our LLM normally does each week) and the LLM made a mistake on every single data entry...along with seven different mistakes affecting twelve of the twenty or so entries, including mistakes that are explicitly spelled out in the prompt. That’s a brutal failure rate. Again, if you use AI/LLM for data collection, you need to take a lot of extra steps to verify and check the data. “Ghosts in the Balcony: A Cross-Country Trip to 58 Theaters Fighting to Survive“ by Matthew Frank in The Ankler I thought Matthew Frank’s pitch to head across America to visit theaters sounded insane aggressive at the time—at least it felt that way to someone a decade older than him; man, to be in your twenties again, am I right?—but I knew the result would be great. And it was, a terrific feature by a great young writer. Also, I loved Matthew’s recent article on who’s getting the precious few entry level jobs in Hollywood. (Hint: nepotism.) “Disney erased FiveThirtyEight“ and “Did Las Vegas get too greedy?” by Nate Silver in Silver Bulletin I love media history and analysis, and there’s no one better to get the history of FiveThirtyEight than from Nate Silver, who wrote about his personal experience in one of my favorite pieces from this year. I also loved Nate’s breakdown of what’s causing Vegas’ woes, but I’ll offer one criticism, summarized as “Might I suggest antitrust?” Many centrists/center-right/libertarian thinkers (Nate is self-described as the latter) often don’t consider consolidation or antitrust as factors in policy issues like housing, America’s military readiness, or, in this case, Las Vegas. Even if libertarians want to debunk antitrust/consolidation concerns, I’d love to read that debunking. In this case, Vegas is incredibly consolidated (though it also has been for a long time) and I’d have loved to read Nate at least contending with this factor, since he addresses almost every other potential factor for Vegas’ decline. “Why Microsoft’s Carbon Removal Pullback Is Such a Big Deal“ by Robinson Meyer in Heatmap News I’m a big supporter of carbon removal efforts, but this nascent industry faces a lot of headwinds, including this big move most recently. I think it’s clear that solar panels and batteries should be able to get the world to its carbon footprint goals, but effective carbon renewal remains necessary to prevent the worst impacts of global warming. “AI is killing the cheap smartphone“ by David Oks LLMs and AI will impact the world in ways we’re not ready for, and already, third world countries are seeing the prices of cheap cellphones skyrocket due to the cost of chips skyrocketing. This article by David Oks is a terrific breakdown. “100 Days of Madness: Netflix, Paramount, Warner and the Future of Hollywood“ by Wade Major at Hollywood Heretic Wade Major dove deep into Hollywood/streaming’s financials in this must read piece. Not that I agree with everything in this article (read my take on Warner Bros./Paramount here) but the analysis is top notch. I think many people discount how quality thinking, regardless of the argument/conclusion, will make you a better thinker. “Erased by the UFC: Frank Shamrock, The MMA GOAT of the 20th Century“ by Nate Wilcox in The MMA Draw Newsletter Growing up playing the UFC fighting game on the Dreamcast, Frank Shamrock was my favorite MMA fighter, and this history/tribute to him was great. Other Fun Reads “The Hardest Part Of History To Tell Is How It Felt“ by Craig Fehrman at Defector “Unmasking the Sea Star Killer“ by Craig Welch at bioGraphic “What Could Save the Industry? Fin-Syn“ by Richard Rushfield in The Ankler Alex Rollins Berg in Underexposed on movie bumpers, pillow shots, Disney trash cinema, cult films, and Casablanca. David H. Montgomery in YouGov’s The Surveyor on punctuation marks, condiments, dinosaurs, and comic strips and kids media. “How Medium finally pivoted its way to profitability“ and “Why the best journalists on YouTube are all former Vox employees“ by Simon Owens in Simon Owens’s Media Newsletter “It’s Not Just You, Netflix Shows Have Gotten Slightly Shorter: Here’s What the Data Says“ by Kasey Moore at What’s on Netflix “Numlock Awards: How Diane Warren became the biggest loser in Oscar history“ by Nathaniel Rakich and “Numlock Awards: The Oscar Bait era is over. The Oscar Chum era is here.” by Walt Hickey & Michael Domanico at Numlock Awards
July Fourth safety guide for fireworks, heat and water this weekend
Firefighters, health officials and water safety advocates share tips for staying safe over the holiday weekend and summer.
Professor Universe brings science, comedy to the library
Professor Universe will make his first appearance at the St. Charles Parish Library this summer with a one-man show that combines science education and comedy. Professor Universe, portrayed by actor, clown, director and teacher Dallas [...]
Marshall Health Network first in West Virginia to offer histotripsy treatment for liver tumors
HUNTINGTON, W.Va. – Marshall Health Network–Cabell Huntington Hospital (CHH) is the first hospital in West Virginia to treat liver tumors using the Edison® Histotripsy System, giving patients access to an advanced treatment that targets tumors with focused sound waves instead of surgery, chemotherapy or radiation. The Edison Histotripsy System uses image-guided sonic beam therapy to precisely target […]
Going outside in this heat? Follow these guidelines to stay safe
Man, it's a hot one! Don't go out in this summer's heat wave before you arm yourself with these tips and a really big water bottle.
Sobble Community Day: Your Go-To PvE Guide
Sobble Community Day makes Inteleon a strong Water-type raid attacker with Hydro Cannon and a valuable future pick for Max Battles.
Onimusha: Way of the Sword Release Date Moved Forward
Capcom has announced that Onimusha: Way of the Sword, the upcoming action-adventure sequel for PC, PS5, Xbox Series X|S, and Nintendo Switch 2, will now be released earlier than previously guided: it will be available on September 4 rather than September 25.
NEW Best In Games Warren: Metro Detroit’s Ultimate Indoor Family Entertainment Center
Located at 28300 Dequindre Road, this massive entertainment destination features everything from an enormous indoor playground and laser tag to go-karts, bowling, arcade games, and even axe throwing…
2026 World Cup Public Health Guide: Expert Safety Tips for Fans
With the World Cup in full swing, the influx of fans is bringing enthusiasm, passion and potential pathogens. An estimated 6.5 million fans are converging across Canada, Mexico and the United States in 16 host cities, and while it’s possible serious diseases can spread during this event, the risk ...
Your guide to summer grilling and heart health - Baylor College of Medicine Blog Network
Dr. Nidal Buheis explains the role red meat plays in heart health and suggests how to enjoy red meat in moderation this summer.
2026 John Deere Classic tee times, TV coverage, viewer's guide
Tee times, TV coverage and viewer's guide for the John Deere Classic at TPC Deere Run in Silvis, Ill.
Best Bets: A quick guide to La Jolla entertainment and experiences
Local events and activities
Netflix and Superheroes Are Having a Rough Stretch on Streaming....
(Welcome to my weekly streaming ratings report, the single best guide to what’s popular in streaming TV and what isn’t. I’m the Entertainment Strategy Guy, a former streaming executive who now analyzes business strategy in the entertainment industry. If you were forwarded this email, please subscribe to get these insights each week.) I have a quick prediction before we start today’s article: You might see this data in future news articles. Not my specific charts or analysis, but the core trend I’ve been monitoring—Netflix is having a lackluster Q2—will become inescapable. Often, folks want to know “What does the data say?” Well, that’s what it says. I haven’t seen this analysis hit the trades really yet, but I have a feeling some other outlets are going to start making this case soon. Remember, you read it here first. You probably have read about the problems facing superhero films at the box office this weekend. Well, this week, I explore whether superheroes are dying on TV as well! And the data says: definitely maybe! We have a lot to cover in today’s Streaming Ratings Report, which covers the two weeks of 18-May and 25-May. Today, I’m just looking at TV, like Netflix’s disappointing Q2, superhero shows underwhelming, a few TV shows dropping off the charts, The Pitt finally ending its epic run on the viewership charts (and whether “view counts” change its status as one of the biggest shows of all time), all the flops, bombs and misses, and a whole lot more. Tomorrow, I’ve got a great rundown of the film side of things. Let’s dive right in! (Reminder: The streaming ratings report focuses on the U.S. market and compiles data from Nielsen’s weekly top ten viewership ranks, Luminate’s Top Ten Data, Showlabs, TV Time trend data, Samba TV household viewership, company datecdotes, Netflix hours viewed data, Google Trends, and IMDb to determine the most popular content. While most data points are current, Nielsen’s data covers the weeks of May 18th to May 31st, 2026. You can find a link to my terminology here.) Subscribe Television - Netflix’s Q2 Slump Continues Having analyzed streaming ratings for going on half a decade, I have learned to trust my gut, but I’m always relieved when I can find actual data to back it up. For example, after a string of very popular shows like Stranger Things, Bridgerton, The Lincoln Lawyer and The Night Agent came out, week after week, in January and February, my gut wondered if Netflix had enough new and returning TV shows to sustain them throughout the year. Since then, Netflix’s post-March slate of shows has not impressed me. This week seemed to feature a potential new hit, but then, like a classic Duffer Bros. TV show, there was a twist. I speak of The Boroughs, Netflix’s latest (and last) Duffer Bros. produced show. The pitch is “Stranger Things with older actors”. And it topped the Nielsen charts: With just two weeks of viewership, The Boroughs would have been a top 25 debut show last year: But here’s the twist: Netflix has already cancelled The Boroughs! What happened? Likely a few things. First, the show didn’t do as well globally as it did in the US. As What’s on Netflix showed, it lagged behind several other shows that got cancelled. Second, its completion rate was likely low; after an initial burst of interest, it quickly dropped off on the Samba TV and Luminate charts. Third, the Duffer Bros. left Netflix for Paramount, and that may have factored into Netflix’s decision here. (Though I tend to believe that if a show is doing well, Netflix would have kept greenlighting seasons.) Still, just because I can explain why Netflix may have cancelled this show doesn’t mean I’m justifying it. In particular, as I’ve noted before, Netflix is losing a lot of their bigger shows as they reach their natural ends, and they need to replace those shows. This show had the hallmarks of a big new genre show, and it’s their biggest hit of the last few months (in the US at least), but now it’s done. Netflix’s other show this week—The Four Seasons, the second season of the “hit” show from last year—definitely disappointed. Its sophomore season had about half the viewership of the first, only 12.7 million hours. It also only had a two week run on Samba TV, and its numbers were all down on Luminate too. In other words, even with two successes, the Q2 slump for Netflix looks real: I could add to the list of disappointments: Both Lord of the Files and Man on Fire had short runs on the Nielsen charts. Running Point’s sophomore season also opened to about half its viewership, similar to The Four Seasons. A Good Girl’s Guide to Murder’s second season—see below—didn’t even make any of the three viewership charts I track, unlike the first season. Netflix is absolutely having a dismal second three months of 2026. If this Nielsen data is any indication, and I think it is, I think this will show up in Netflix’s engagement report, and maybe even their financial outcomes. And the rest of June doesn’t look much better. We have two hit shows coming back—Sweet Magnolias, one of their quietest big shows, and Avatar: The Last Airbender, a big hit for them in 2024—but the other big swings are limited series crime thrillers i.e. no future season potential. Like I said above, sometimes when I uncover a juicy nugget like this, other outlets end up writing very similar articles mimicking the data without credit. We’ll see if that happens this time! Share Television - The State of Superhero Shows on Streaming When I first heard the pitch for Spider-Noir—a Sony TV show on Prime Video that binge-released eight episodes first on MGM+ then on Prime Video two days later—I had my doubts. It’s a live-action Spider-Man show set in the 1930s, starring Nicholas Cage, based on a cameo of a character in Spider-Man: Into the Spider-Verse. No, seriously, that’s the pitch. That could either go terrifically well or horribly wrong. Great because, Spider-Man. He’s the biggest superhero we have. I’ve seen tracking numbers that put the new _Spider-Man: Brand New Da_y as the blockbuster of the year and initial pre-sales back that up. And yet this Spider-Noir pitch feels very esoteric. (Also, the eight-episode binge release feels very “Amazon copying Netflix” again.) So what’s the data say? And what does this say about the future of superhero shows?
Science Says Driving A Stick Shift Is Good For Your Brain
The manual transmission may have another argument in its favor beyond driver engagement.
Amazon Is Awash With AI-Written Guideslop For Unfinished Games
Buy your novel-like, image-free, hallucinated guide to Alien: Isolation 2 today!
Help start the conversation on mental health
A new guide from the Kentucky Injury Prevention and Research Center is helping healthcare providers start meaningful conversations about mental health during routine visits.
What to Do in Houston If You're Here for Business (2026)
Make the most of your work trip with these restaurants, bars, coffee shops, and downtime destinations.
Wimbledon 2026 preview: Serena Williams, Jannik Sinner, Novak Djokovic
Serena Williams, Jannik Sinner and Novak Djokovic feature in our essential guide to Wimbledon 2026.
Elliot Anderson’s Manchester City transfer arrangements see last-minute change
Adaptations have been made to the final medical checks for Manchester City’s record transfer for Elliot Anderson.The 23-year-old put in an 84-minute shift to help guide England through a highly comp...
MINNEAPOLIMEDIA PRESENTS | This Weekend in the Twin Cities – Entertainment Guide: June 26 ~ June 28, 2026 Edition
Twin Cities Pride, Breakaway, Broadway, concerts, festivals and family fun headline one of summer's biggest weekends across Minneapolis and Saint Paul.
Meet Troy Rohrbaugh and Doug Petno, who are vying for Jamie Dimon's job
Doug Petno and Troy Rohrbaugh are the frontrunners to succeed Jamie Dimon. Here's a guide to the men in line for one of Wall Street's top jobs.
Where to find free summer entertainment in Boston
Our guide to free summer music, movies, and theater.
From Supergirl to Muse: your complete entertainment guide to the week ahead
Milly Alcock’s Kryptonian hero bops baddies with a superdog in tow, while the Devon band return with another collection of all-caps rock
Guided kayak tours stopped at Pinellas Bayway South
FDOT said no private for-profit business is allowed to operate within the state transportation facility right of way per Florida Statute.
We almost had a smartphone in the 90s. Why did it fail?
In the early 90’s, a company called General Magic began working on a portable device that would allow people to check email, make phone calls, even play games. It was basically a smartphone. But it never caught on.On today’s show, a theory about why this device failed. General Magic had generous investors, world-class talent and creative freedom. But is it possible what they needed was constraints?Support:Planet Money+Read: Our book: Planet Money: A Guide to the Economic Forces That Shape Your Life Our weekly longform Planet Money newsletterOur weekly Indicator round-up newsletterFollow: InstagramTikTokYouTubeFacebookThis episode was hosted by Erika Beras and Emma Peaslee. It was produced by Emma Peaslee with help from Sam Yellowhorse Kesler and James Sneed. It was edited by Marianne McCune and fact-checked by Charlotte Isidore. It was engineered by Jimmy Keeley with help from Cena Loffredo. Alex Goldmark is Planet Money’s executive producer.
MSI Claw 8 EX AI+ pre orders extend to the UK, including Launch Pack bundle, here’s where you can buy one
You can now pre-order the latest MSI Claw handheld and/or its Launch Pack in the United Kingdom. More retailers will stock it soon.
MINNEAPOLIMEDIA PRESENTS | This Weekend in the Twin Cities – Entertainment Guide: June 26 ~ June 28, 2026 Edition
Twin Cities weekend features Pride, Breakaway, concerts, festivals, theater, museums and family events across Minneapolis, St. Paul and beyond.
City council members request special meeting on planned Sports and Entertainment District
San Antonio Council Districts 1, 5 and 7 want a special meeting before Aug. 7 to guide public input on the Spurs arena’s $75M Community Benefits Agreement as the city considers a $489M Sports and Entertainment District.
Making Our Own Luck
We are cross-posting a piece that former NIH official Kris Willis wrote for Macroscience. Kris is now the President and Founder of the Woodley Park Institute, for which I’m a board member. Picking winners or hedging bets? Federal science agencies have long wrestled with the question of how to ensure their billions of dollars of grants and contracts result in maximum benefits for Americans. On the surface, it might seem that a goal-oriented, interventionist style of management would be the best policy: prioritize our most pressing problems and distribute funding accordingly.This top-down strategy creates a unique hazard, though: bad choices can send resources in the wrong direction, resulting in slow progress that impedes the delivery of tangible benefits to citizens. Moreover, if decision makers pursue an applied advance when the underlying scientific principles remain poorly understood, they risk costly failures and a loss of support for the research enterprise at large. Examples include Nixon’s 1971 War on Cancer, undertaken on the premise that a cure could be achieved in less than a decade, the drive to build an operational commercial fusion plant by the mid-1990s, and the National Plan to Address Alzheimer’s Disease, which failed to produce the effective treatments and prevention strategies promised by 2025. The contrasting laissez-faire approach is to hedge your bets. If the path to an advance is impossible to predict, then the wisest choice might be to distribute funding to as widely as possible. The main risk of this strategy is that spreading funding thinly may limit the resources available to the most promising research, resulting in the same negative outcomes as the interventionist approach: limited support for the most promising topics, slow progress, and delayed returns. In reality, at science agencies like the National Science Foundation and National Institutes of Health, program managers navigate between these two extremes, setting some funds aside to target high-priority areas and using the rest to cover the widest possible range of meritorious proposals. This middle path seems like the most rational way to proceed, but it still requires making choices. How much should be set aside for high priority topics? What should those topics be? How should we define merit? Expert opinion can provide a helpful guide, but leading experts can have remarkably different opinions about what matters and what should be prioritized. Moreover, experts and administrators alike can be risk averse, giving an edge to high-profile, well-established concepts. What’s really needed is a data-driven framework to help guide decision-making, one that doesn’t simply repackage prestige or incumbency. Recognizing breakthroughs years in advance Many breakthroughs fail to attract funding or recognition at the earliest stages of development. Katalin Karikó, for example, spent years struggling to win grants for work on mRNA that would eventually win her and Drew Weissman a Nobel Prize. Similar stories can be told about Jim Allison’s groundbreaking studies leading to the development of cancer immunotherapy, Stan Pruisner’s demonstration that prions can self-replicate without DNA, or Robin Warren and Barry Marshall’s proof that Helicobacter pylori, not stress, causes ulcers. Yet at some point, the scientific community recognizes and responds to transformative breakthroughs like these. How does that change happen? And what if science funders could identify the areas that are on the cusp of a breakthrough? Those questions led my collaborators and me to study how scientists responded to past breakthroughs. Based on patterns in that data, we developed a means of predicting future breakthroughs, using biomedicine as a proof of concept. It’s worth taking a moment to describe how our approach works. Briefly, our prediction process begins by grouping the 18 million or so peer-reviewed papers in PubMed, the authoritative database of biomedical research, into roughly 50,000 unique topics. A small subset of these topics are so widely acclaimed as breakthroughs that they have been recognized with a major prize like a Nobel or a Lasker Award. We theorized that studying the development of these outliers over time, especially before they gained acclaim, was the key to identifying future instances of them. After defining topics, we chose 21 representative breakthroughs and asked what they looked like before they won prestigious prizes. To answer that question, we re-ran our topic-mapping algorithm repeatedly, winding back the clock one year each time, stringing together the years to follow the progress of each field as it grew and advanced. We found that in each case, the years leading up to a discovery followed a pattern: a burst of papers on a new, rapidly evolving topic, many of which quickly became influential. These characteristics—the percent of papers that are new, the percentage of papers that are brought in from other topics, and the influence of each individual paper—can all be measured separately for any given topic. Together, they act as a predictive signal that is detectable an average of five years before a transformative discovery is made, and up to thirty years before the discovery receives a major prize. Scanning the current research landscape for topics that display this signal allows us to predict what work will likely produce a future breakthrough. Each year we analyzed includes four or five signals, a number that appears to have remained constant across a twenty year time frame. In their classic work on the sociology of science, Bruno Latour and Steve Woolgar established that the desire to participate in a major discovery is an important motivator for scientists as they consider whether they should take up (or abandon) a research problem. Although further work is needed, the simplest explanation for our results is that this behavior is widespread enough to detect at scale. A foundational advance, or something like it, draws the attention of scientists and causes them to change the direction of their research. They vote with their feet, staking their own reputation and careers by publishing on and citing the new idea. That upswell of interest is the foundation of our breakthrough signal. What kind of research does our model identify as a breakthrough? After building a model based on the patterns in our 21 preselected breakthroughs, we tested it by identifying all early signals of discovery from 1994 through 1997. Of the 18 signals we found in that time period, 17 can be traced forward in time to a breakthrough. Examples include super-resolution fluorescence microscopy (see the image above), the directed evolution of proteins and enzymes (Chemistry Nobel, 2018), and sequencing the human genome (National Medal of Science, 2008). The discovery of the role of leptin signaling in obesity is a particularly interesting case study. Around 1950, scientists noticed the existence of a type of lab mouse that suffered from a unique inherited form of obesity. When given the freedom to choose their own diet, these mice ate more than normal and preferred food that was high in fat. Researchers had few clues as to why the animals overate; early experiments pointed to the existence of a soluble ob factor found circulating in the bloodstream that regulated appetite, but its identity was unknown. In 1994, Jeffrey Friedman and colleagues identified and sequenced the ob gene, noting that the protein it encoded appeared to fit the profile of a circulating factor. A year later, a trio of high-profile publications demonstrated that ob was a hormone that regulated body weight and fat deposition by regulating appetite. One of these was co-authored by Friedman, who christened it leptin from the ancient Greek word for thin. Using our model, the data from 1996 make it clear this advance would become a breakthrough. Scientists had flocked to study the biology of the new hormone, generating the flurry of new papers and citations required to produce a signal. One of these demonstrated that serum leptin concentrations reflected the amount of adipose tissue in the human body, providing clinical validation of the earlier mouse studies. Before the identification of leptin, scientists were unable to point to a specific molecule that controlled appetite and adiposity, so that it was impossible to rule out non-physiological causes of obesity; its characterization fundamentally changed our concept of weight gain. In 2010, Friedman and fellow pioneer Douglas Coleman were awarded a Lasker for the discovery. Our work also identifies breakthroughs in clinical practice and behavioral and social sciences, even though these areas are less likely to draw the attention of major prize committees. One example that falls into this category is the introduction of endovascular aneurysm repair, a minimally invasive surgical procedure for the treatment of abdominal aortic aneurysm, a leading cause of death among Americans over the age of 65. Relative to the previous standard of care, it reduces in-hospital mortality by almost four-fold. In 2017, Timothy Chuter received the American College of Surgeons’ prestigious Jacobsen Innovation award for his multiple refinements to the technique. Another under-recognized breakthrough identified by our model is the development of standardized survey instruments to assess the quality of life for HIV+ patients. The antiretroviral cocktails introduced in the mid-1990s reduced AIDS mortality, but treatment came with serious side effects. The new evaluations showed that patients whose disease progressed had worse physical functioning than Americans with other chronic diseases, while those who were asymptomatic maintained a health-related quality of life on par with the overall US population. This evidence made it possible for patients and activists to argue that even in the absence of a total cure, and in spite of the side effects, alleviation of symptoms was a worthwhile priority for clinicians. My colleagues and I have failed to identify any significant recognition for the physicians and health policy experts who pioneered this advance, although in 2016, researchers called for the World Health Organization to set targets for good health-related quality of life as part of its framework to end the AIDS pandemic. From forecasting to funding How should science funders use our predictions? Any serious discussion of what we should do with this new capability needs to begin with an understanding of its limitations. We can’t (and shouldn’t) invest all of our resources in the small number of topics predicted to produce breakthroughs. Innovative new fields are born from existing ones; they rarely arise de novo. If funders don’t maintain a diverse portfolio, the breakthroughs of tomorrow will have no antecedents. Think of this as eating the seed corn, or killing the goose that lays the golden egg. There are also multiple goals of funding beyond basic scientific discovery, including translating discoveries into clinical practice, developing new technologies, supporting economic development, and training new scientists. The investments needed to accomplish these goals are likely different from those required to support emerging breakthroughs. Finally, we must be aware that we may not capture every instance of a breakthrough. The concept is fuzzy, and not every significant discovery is recognized with a major award. Further, breakthroughs are rare, meaning that our dataset is, by necessity, small. This makes formal estimates of accuracy challenging. Although our overall success rate appears to be high, any one signal may turn out to be a false positive. We found one apparent example: the development of the third generation COX-2 inhibitors, Vioxx and Celebrex, which were much celebrated in the early 2000s as effective but non-addictive pain relievers, meets all the algorithmic criteria of a breakthrough. Five years after it received FDA approval, researchers demonstrated that Vioxx was associated with serious cardiovascular complications, and the manufacturer voluntarily pulled the drug from the market. Celebrex remains available, although like other NSAIDs, it carries an FDA warning for increased cardiovascular risk. Decision makers who were overly focused on the breakthrough potential of this research might have wasted substantial resources nurturing an area that ultimately proved to be a failure—but so would those who relied on expert opinion at the time. That said, the potential benefits of funding the next mRNA vaccine or cancer immunotherapy years earlier than we might have are large. When we can’t assume the outcome of an action, it’s worth conducting an experiment. Can targeted support for areas that are poised to produce a breakthrough increase the return on scientific investment without cannibalizing future advances? With the necessary administrative infrastructure in place, conducting this experiment would be straightforward. First, identify all the breakthrough signals between 2018 and 2023, select half at random, and commit to a decade of investment. For biomedicine, a six year window should yield about 30 topics with the potential to produce a breakthrough. Providing strong support to half of these might be accomplished for $300 million a year. That’s roughly half of the recent annual budget of the NIH Common Fund or around 20% of the fiscal year 2025 budget for ARPA-H. After five years, then again at ten, compare to see which group — the one that was actively managed, or the control — produced more breakthroughs, and on what timescale. Although we used biomedicine as an example, the same experiment could just as well be run for physics, materials science, or any other discipline. Any attempt to undertake such an experiment should keep three points top of mind. First, we can predict the topic of future breakthroughs, but the people and vision for how to move the work forward are still important. In practice, this means success requires active program managers with the expertise to develop the science and the authority to do so, including by recruiting investigators. Second, we would be wise to learn from the failures of past attempts to fund transformative research. High among these are funding modestly repackaged work, confusing the genuinely novel with the merely unfamiliar, and relying too much on incumbent investigators. All of these risks can be mitigated by thoroughly and intelligently integrating high quality data into portfolio management. Finally, we need to have patience. Even with strong funding support, producing a breakthrough takes time. If supporting breakthroughs is the best way to nurture the birth of new fields, we also need to accurately describe and properly manage the other two stages, so that we invest wisely throughout the productive lifetime of ideas and divest once they reach the point of diminishing returns. We would benefit from more study of all of these phases, especially the transition from one to another. More research could answer questions like: When does a breakthrough become an established field? How do the availability of funding, the size and characteristics of the available workforce, and the accumulation of evidence that disagrees with prevailing models affect a field’s decline? Exactly how do old ideas give birth to new ones, and can we speed up the process? The more we understand about the dynamics of scientific progress, the better we can maximize the odds that our curiosity leads to results. I’d call that finding a way to make our own luck.
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