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Smart Adhesive Is Key to Crease-Free Foldable iPhone Display
Advances in optically clear adhesive (OCA) will be a key factor in achieving a near-invisible crease in Apple's first foldable iPhone expected later this year, according to TrendForce. The supply chain intelligence firm outlined the key technologies in a new report on foldable display innovation, explaining that creases form when layers within the display panel fall out of alignment, concentrating stress at the fold and causing micro-cracks or permanent deformation over time.
New Rules May Allow Broader Picks for CDC Vaccine Panel
By HealthDay Staff HealthDay ReporterMONDAY, April 13, 2026 (HealthDay News) — The Advisory Committee on Immunization Practices (ACIP) could soon have a new focus after officials changed the rules that determine who can serve on it. The updated rules were approved by Health Secretary Robert F.
Porsche Patents Racing Stripes That Appear When You Switch Into Sport Mode
Using an electrical current to change the outward appearance of certain body panels, this Porsche tech could make racing stripes appear on command.
This Week in Missouri Politics - April 12, 2026
Scott Faughn is joined by Chuck Hatfield and Marc Ellinger. On the panel, Jake Kroesen is joined by State Rep. David Casteel.
Student-led sports business conference brings industry leaders to campus
University of Illinois event highlights careers in athletics, media and analytics through panels and networking.
This accessory lets you play Switch 2 games on your iPad or iMac display at 4K resolution
Apple has included excellent display panels on iMacs for years, but for the longest time, there hasn’t really been a...
Female students, leaders gather for Business of Her conference
More than 200 students and other female leaders gatehred at McKenna Hall for the Business of Her conference.The day was full of panels, breakout sessions, insp
Trump wants to paint a White House office building with ‘magic paint.’ Experts advise against it
President Donald Trump privately advocated for painting an ornate federal office building next to the White House with a “magic paint with silicate,” CNN has learned. But ahead of a key vote on exterior changes to the sprawling Gilded Age structure, a panel of experts is warning the so-called magic paint could be incompatible with the Eisenhower Executive Office Building’s granite exterior.
“AI polls” are fake polls
A few weeks after Donald Trump’s second presidential win, I took the train up from London (where I was living at the time) to Oxford to attend a conference on polls and forecasts of the 2024 election. Most of the attendees were pollsters or academics, but I also watched presentations from Aaru and Electric Twin, two companies that do what is interchangeably called synthetic sampling, silicon sampling, or synthetic audiences. Stripped of startup jargon, that means they use large language models (LLMs) to simulate responses to public opinion polls by having AI agents take on the role of survey respondents. I had already heard of Aaru thanks to some articles with eye-catching headlines like “No people, no problem: AI chatbots predict elections better than humans” in the months leading up to Election Day. The founders were making some big, some might even say far-fetched claims, such as: “within two years, we will simulate the entire globe — from the way crops are grown in Ukraine to how that impacts production of oil in Iraq, trade through the strait of Malacca, and elections for the mayor of Baltimore.” When Semafor asked Aaru’s cofounders — Cameron Fink and Ned Koh — about my boss, they said “we respect all those who came before us.” Nate (as he so often does) shared his thoughts on Twitter: Fink and Koh were relatively good-natured about this back-and-forth when we spoke at Oxford. They even offered to mail me one of the t-shirts featuring Nate’s quote they apparently had made. I never took them up on the offer, which I now somewhat regret. These synthetic sampling companies fell off my radar for a while, but they do still exist. In fact, Aaru recently received a $1 billion valuation. Is what they’re doing anywhere close to the most important frontier in AI development? Not by a longshot, especially when Anthropic just developed a model so adept at exploiting software vulnerabilities that it’s only being released to 40 companies. Still, silicon sampling is increasingly finding its way into public polling. Axios reported in March that “a majority of people trust their own doctors and nurses” based on findings from Aaru — without mentioning that the “people” in that sentence were actually LLMs. Around the same time, the Public Sentiment Institute “boosted” their online sample of 373 real survey respondents with 114 AI agents.1 (Spoiler alert: even the co-founder of Electric Twin doesn’t think that’s a particularly defensible approach.) Polling companies like Qualtrics and Ipsos are also developing synthetic data panels. So, what should we make of these … “polls”? Let’s get one thing out of the way: whatever they are, they’re not polls in the way that term is usually defined. Subscribe You can’t replace polls with AI On one hand, using LLMs to essentially make up fake survey respondents sort of sounds like the dumbest idea ever, one that will at best imperfectly replicate real polls while introducing all sorts of biases. On the other hand, with LLMs improving at a remarkable, perhaps even alarming rate, maybe that means I’m a dinosaur at the ripe old age of 24 because I still want to rely on polls that talk to actual people. I’m not going to argue that synthetic samples are completely useless. In fact, as I’ll return to later, there is evidence that some techniques can replicate topline survey results quickly and cheaply. But the marketing from certain companies can be slightly optimistic. “No traditional poll will exist by the time the next general election occurs,” said Fink in 2024. We’re just 206 days away from the midterms, and based on the fact that I still have to collect a bunch of polls every day, I’d say he should have run that prediction by a sample of AI agents before the interview.2 To see why synthetic samples can’t replace polls, here’s a quick primer on how they work. The simplest version of these models involves taking a LLM (like ChatGPT or Claude), giving it a demographic profile (e.g., a white, college-educated woman who lives in Utah and makes $70k a year), and then asking it to respond to a survey question. You repeat that process a few thousand times using different demographic profiles and end up with a sample of synthetic survey responses. The actual models used by private companies are more sophisticated than this, usually because they incorporate more hypothesized demographic characteristics for each agent and provide them with extra information. Aaru, for example, feeds agents a diet of news and information they’d be likely to consume, while Electric Twin incorporates their customers’ proprietary data about the audience they’re trying to replicate. The way Ben Warner, the co-founder of Electric Twin, explained it to me was “we have a large amount of data on […] for instance, 5,000 people. Can we make an accurate prediction of how they would respond to another question?” Still, it should be obvious why synthetic samples can’t replace polls. Polling is fundamentally a data collection process. We might use surveys to make predictions by feeding them into election forecasts, but the main purpose of a poll isn’t prediction, it’s gathering new data about what people think and how they feel. Silicon sampling, on the other hand, produces no new data. It’s simply a model: you input LLM training data, demographic prompts, and a bunch of other information, and it spits out a prediction for what a poll would say. We love models here, but models aren’t polls. That difference is an important philosophical sticking point for most pollsters I talk to. “I think politics should stay away from [synthetic sampling], because we’re trying to […] represent the voice of the people,” said Natalie Jackson, a vice president at GQR Insights. Democratic pollster John Hagner told me: “I think I’m just incredibly skeptical of this idea. I don’t think it’s research. At that point, you’re asking the machine to tell you what you already believe.” Hagner has seen some presentations of early synthetic sampling experiments, but so far, “if it’s being used in a campaign, people are keeping it incredibly quiet.”3 But Eli, I hear you saying, aren’t polls themselves increasingly governed by modeling decisions? Indeed they are: pollsters’ choices on which sampling method to use, how to define their likely voter models, and how to weight their samples can and do lead to dramatic differences in the results they publish. Aaru even referenced these limitations in the methodology statement included with that maternal mortality “poll” — although I’m using the term “methodology statement” loosely here, because it doesn’t really explain how the model works at all. We can ignore the (frankly preposterous) implication that synthetic sampling isn’t subject to a separate set of biases. The important point is that there’s still a meaningful difference between using weighting and other statistical techniques on actual polling data and using a model to predict what a poll would say. The latter is far closer to election forecasts or techniques like MRP — potentially useful models, but not a replacement for polls.4 To be fair, other synthetic sampling companies are perfectly happy with the distinction between polls and models. Warner compared polling and synthetic sampling to different tools in a toolbox. “The mistake I think we make is we think that these new tools should either work in exactly the same way or somehow replace these old tools,” he said. “Rather than thinking of it as, okay, so we’ve always had the hammer, we’ve always had the screwdriver, now we’ve got a saw. But don’t use a saw to try [to] do the job of a hammer.” A quick comment from Nate Eli didn’t ask me for a comment — rather rude of him, don’t you think? But since I’m editing this story, I figured I’d add a few quick thoughts rather than putting words in his mouth. Beyond the frequently misleading marketing, what bothers me about the AI “poll” hype is that as AI tools make statistical inference cheaper and/or better (note that these are not synonyms) that actually increases the comparative value of collecting original data. You might be able to train a model to make a reasonable estimate of what some hard-to-reach poll respondent would say — say, a young Black man who voted for Trump. (Such a person checks a number of boxes for a voter who is usually hard to reach in surveys.) Indeed, this is closely related to what models like the Silver Bulletin forecast already do. They essentially smooth out the kinks in noisy survey data by making inferences based on past voting patterns or national polls or surveys of other states. But you don’t actually know what these voters think unless you’re reaching them directly. If there’s a shift in opinion among this subgroup, you’re not going to detect it. So if I were running a campaign, I’d invest more in going the extra mile to find a representative sample of those voters. And then I’d hire some smart quants — or Claude? — to figure out the implications for campaign strategy based on proprietary data that my competitors didn’t have access to. -Nate Silver Are these models any good? If synthetic surveys are just a new type of model, the next obvious question is whether the models are at least accurate. The answer very much depends on who you ask. On one end of the spectrum, you have the maximalist argument that synthetic sampling is more accurate than actual polls. “It’s an incredibly challenging problem to go to someone and say ‘hey, we’re going to be more accurate at predicting human behavior than you, even when you talk to your customers directly’,” Koh recently told CNBC. In his view, synthetic sampling isn’t a saw to polling’s hammer, it’s “magic.” There’s certainly evidence that synthetic samples can replicate certain survey toplines. But if Aaru does have any examples of their approach outperforming the polls, they’re keeping those to themselves.5 Aaru’s 2024 election model, for example, had Kamala Harris leading in Michigan, Nevada, Pennsylvania, and Wisconsin on November 4th. And although they’ve since taken down their forecast page, they gave Harris a 50.5 percent chance of winning the race on November 2nd.6 After the election, Fink told Semafor he was happy enough with those results because they were “within margin of error,” a term that is completely meaningless when applied to a “sample” of AI agents. And of course, Aaru says their models have improved since 2024, so supposedly now they’d be more accurate than the polls? Still, their stronger argument is on cost: “We are significantly faster and cheaper than traditional polling, and still more accurate,” said Fink. The first two claims are undeniably true, but the third brings us to the opposite end of the spectrum. Both Jackson and Hagner are skeptical that these models are reliable for anything beyond replicating common survey toplines. “I just […] don’t think the machines are what we want when we’re looking for nuanced views. My example on this is people in Arizona and Nevada in 2024 who voted for Trump and voted for expanding abortion in their states on ballot initiatives,” said Jackson. Hagner identified another issue. Maybe the synthetic respondents, like sycophantic LLMs, are inhuman in one important way: they’re too nice. “The reports that have come through at the meetings that I’ve been at are that the early experiments on this, they cannot get respondents to be as racist or sexist or, frankly, as negative as human respondents,” he said. Academic research mostly agrees on this point. While there are some papers that show promising results when using LLMs to replicate polling data, most show that LLMs suffer from various quirks like producing too few “don’t know” responses and can seriously overpredict the favorability of politicians like Donald Trump and Kamala Harris. They also seem to struggle with too little variation between demographic subgroups, so the difference in predicted opinion between Democrats and Republicans, for example, is too small. When I asked Warner about these studies, his response to these papers was that just because academics can’t get synthetic sampling to work doesn’t mean that the technique doesn’t work in general. “Actually, the argument is, okay, yours does not [work]. That does not mean […] for this complex set of machinery, which uses a lot of investment, a lot of time, a lot of money, you can’t get it to work.” Cards on the table, I’m somewhat sympathetic to this argument because academics aren’t exactly great at making election forecasts. Usually, the people with skin in the game are the most accurate. Warner’s argument is that the approach Electric Twin takes — which includes, for example, making multiple predictions for each synthetic respondent using different models and prompts and subsequently averaging those to get a final prediction in a sort of ensemble forecast — produces better results than the simpler academic models. Warner shared a comparison between his method and the method from a recent academic paper with me, and Electric Twin was indeed able to get more accurate replication. But even still, he acknowledged that synthetic sampling “is not a crystal ball.” “If you asked me, do I think using other data sources will be more accurate than asking somebody who they will vote for, I would probably say no. But if you asked me ‘would your system be useful for our turnout modeling today?’ I would say yes.” For better or worse, it looks like the method is already getting more popular in the market research world. Most of the clients Aaru touts these days are businesses like EY and McDonald’s. And AI will probably begin to pop up in other parts of the political polling process. Pollsters are already using it to code open-ended survey responses, and some firms, like YouGov, are testing using LLMs to ask survey respondents questions. More worryingly, one danger to actual polls is that AI agents can be used to infiltrate online surveys. Most online polls use various checks to prevent that from happening, but there’s conflicting evidence on how effective those filters are and how prevalent AI agents currently are in online panels. If those agents ever become impossible to detect, it might spell the end of online polling, but the solution isn’t to replace all of your respondents with ChatGPT. Silver Bulletin is a reader-supported publication. To receive new posts and support our work, consider becoming a subscriber. Subscribe 1 That particular poll obviously doesn’t meet Silver Bulletin standards for aggregation. But we exclude all Public Sentiment Institute polls from our averages because we classify them as an amateur polling firm. 2 You could argue that Fink meant the next presidential election, but (a) I’m also confident we’ll still have real polls in 2028 and (b) in that case he should have asked an LLM to define “general election.” 3 Quick caveat: that’s reporting from a Democratic pollster. It’s possible that Republicans are more willing to use AI in political campaigns. 4 Indeed, Silver Bulletin does not include “polls” produced by MRP in our forecasts or averages, and we think it’s extremely misleading when their practitioners describe them in a way that suggests original data had been collected among a large number of states or Congressional districts. 5 A recent report from Aaru and EY did show two examples of a synthetic estimate being closer than a survey to a real-world benchmark — but I’d take those findings with a grain of salt because the report reads more like an ad and didn’t involve any sort of prediction being made ahead of time. 6 For comparison, our odds for Harris on the same day were 48.2 percent.
State of Small Business in Austin- The Economic Outlook in 2026
Explore how 2026 economic trends are shaping growth opportunities for Austin's small businesses. Kick off Austin Small Business Week (May 4-8) with Austin Economic Development at the State of Small Business in Austin breakfast and panel discussion.
Jelly Roll’s Blood Test Results Are a Wake-Up Call: What Blood Tests Should Your Family Actually Be...
Jelly Roll’s blood panel results stunned his doctors. If you manage your family’s health, his story is worth reading.
RFK Jr.’s new vaccine panel rules may help sidestep court order, experts say
Kennedy signed a new charter for the CDC’s vaccine advisory committee, adding more focus on vaccine injuries.
MSI MPG 322UR QD-OLED X24 Review - Less Expensive and Even Better
MSI MPG 322UR QD-OLED X24 brings fifth generation V-Stripe QD-OLED technology to a 32-inch 4K panel, pairing a 3840×2160 resolution with a 240 Hz refresh rate, a 80 Gbps bandwidth DisplayPort 2.1a UHBR20 interface, and a price tag that undercuts its predecessor by $200. Improved text clarity, higher SDR brightness, and an AI Care Sensor make for a strong all-around package.
Kamala Harris says she ‘might’ run for president in 2028. Is she what Democrats are looking for?
The Trump administration just updated rules for CDC's vaccine advisory panel, allowing inclusion of RFK Jr. allies
The changes published Thursday come after a recent legal defeat that has at least temporarily halted meetings of the Advisory Committee on Immunization Practices, which for decades has recommended how best to use the nation’s vaccines.
ATU Hosts 2026 High School Business Challenge
Searcy High School student Duaa Choudhary earned the top prize in the 2026 Arkansas Tech University High School Business Challenge, which concluded with final presentations before a panel of judges on Thursday, April 9. Participants were asked to develop a business start-up or expansion idea. Choudhary earned first place and…
Scientists to discuss Suncoast environmental threats at free Sarasota panel
One researches dolphin pods in Sarasota Bay. Another studies the impacts of pollution in area waterways. A third leads a consortium that strives to bring awareness to the work of local scientists. Those experts, along with another local environmental advocate, will lead a panel discussion moderated by Suncoast Searchlight on
Celebrate Amazing Stories and Science Fiction’s 100th Birthday
Doors Open 7:15 p.m. Celebrate Amazing Stories and Science Fiction’s 100th Birthday with us! In April 1926, Hugo Gernsback published Amazing Stories magazine for the first time, and while the name of the genre took a few more years to become a household term, many credit this moment with the birth of Science fiction fandom as we know it today! Join us for a two-panels featuring a discussion on the impact of Amazing Stories and Science Fiction as a genre! Featuring published authors, scholars, and podcasters with deep knowledge of the history and great works of the last 100 years. The second panel will be a how-to guide for writing your own Science fiction stories or novels, including teachers, authors, and scholars of the genre. Verbatim Books on Facebook / Instagram
Pixel 11 Series to See Big Display Upgrade
Industry sources have confirmed that Google’s upcoming Pixel 11 series will utilize Samsung’s new M16 OLED panels. These are the same panels expected to be used by Apple for its... #Google #Pixel11
New Charter Allows RFK Jr. to Reclaim Vaccine Policy Despite Court Ruling
The charter, published on Thursday, alters the makeup and purpose of the panel, opening the door for Health Secretary Robert F. Kennedy Jr. to reclaim his revision of national vaccine policy.
Chicharito joins Henry, Ibrahimovic as Fox Sports 2026 World Cup analyst
Mexico's all-time leading scorer adds to a star-laden panel of TV analysts for this summer's World Cup
NCAA to discuss five-year eligibility proposal, reports say
An NCAA panel is scheduled to discuss changes to eligibility rules that would give athletes five years to complete their eligibility, sources said Wednesday.
Organizers of Black maternal health “Born to Thrive” panel discuss upcoming event
Why Microsoft’s war on Windows’ Control Panel is taking so long
It’s all to do with pesky printer and network drivers.
Remigration and the New Far-Right Politics of Mass Deportation
Panelists will explore the various interpretations and adaptations of a remigration agenda to fit local political and social contexts in Europe, the UK, and the US, offering regional perspectives on this growing transnational narrative and its implications for democratic governance, civil rights, and the future of immigration policy.
Can political divisions be fixed as shutdown and gridlock continue
As a partial government shutdown continues, Texas lawmakers discussed growing political divisions at a civil discourse panel. Some pointed to leadership and social media as factors, while others called on voters to demand cooperation. NBC 5’s Phil Prazan has more.
Ferguson’s failure to fill WA campaign oversight panel spurs recall bid
Two of the commission’s five seats have been vacant for months. Leaving them open for that long violates state law, according to the recall petition.
Microsoft explains why it still can’t fully kill Control Panel in Windows 11
Microsoft is phasing out the Control Panel in Windows 11 in favor of the Settings app, but the transition is careful due to old drivers.
RFK Jr. rewrites rules on CDC panel after judge blocks vaccine changes
After a federal judge said members of the influential vaccine committee were "distinctly unqualified," an updated charter broadens the list of expertise for membership.
IGN Entertainment and Dentsu Gaming announce Women in Gaming UK event
Networking event features panels, headshot studio, and hardware demos
State election officials wonder if massive federal voter database will be used to sow doubts about midterm elections
Scientists Are Recycling Centuries-Old Bullets for a Badly Needed Toxic Compound
Researchers want to recycle more lead waste for high-tech solar panels via a new method.
Scientists Are Recycling Centuries-Old Bullets for a Badly Needed Toxic Compound
Researchers want to recycle more lead waste for high-tech solar panels via a new method.
Apple’s folding iPhone redesign looks stunning in new images
Get a fresh look at the upcoming folding iPhone, as leaked images reveal a refined camera design and sleek back panel.
Supreme Court sides with Steve Bannon in bid to dismiss Jan. 6 conviction
The influential right-wing podcaster spent four months in prison for defying a subpoena from the House panel investigating the 2021 assault on the U.S. Capitol.
Streaming Summit Gets Down to Business
Panelists to tackle practical realities of monetization, metrics and live sports delivery
Lawmakers seek permanent funding for referral hotlines connecting families to mental health care
A bill heard by a Rhode Island Senate panel last week would fold funding for telephone hotlines used by pediatricians and family doctors to connect kids and parents to mental health treatment hotlines into a health department program funded by insurer contributions.
Vault: The break from crypto politics is over
It’s been three months since the collapse of the Senate Banking Committee’s effort to advance a landmark crypto market structure bill. Now, with election season right around the corner, the panel is gearing up to try once more.
This Week in Missouri Politics - April 5, 2026
Scott Faughn is joined by Governor of Missouri Mike Kehoe. On the panel Scott is joined by Reps. Bennie Cook, Mazzie Christensen, Nick Kimble and Missouri Times Editor Jake Kroesen.
From Policy to Practice: Shaping the Future of Health Care
Join us for a panel discussion exploring how policy decisions are shaping the future of health care.
H.H.S. Takes a First Step Toward Restoring Vaccine Advisory Committee
A federal judge last month questioned the legitimacy of the panel and overturned its recent work. A notice suggests that it may be revived on Robert F. Kennedy Jr.’s terms.
New CNN poll shows Democrats up big heading into midterm election season. Can Republicans claw back to avoid a blue wave?
Pete Buttigieg Calls For a Politics of ‘Belonging’
A Kennedy School panel discusses polarization and the uncertain future of American democracy.
Big Month for Small Business in Macon-Bibb
Macon-Bibb County’s Office of Small Business Affairs (OSBA) hosted and co-hosted five workshops and panels throughout March, reaching nearly 800 participants across the community. “These workshops and panels are about making sure our small businesses have access to the information, connections, and opportunities they need to grow,” said OSBA Director Charise Stephens. “When we invest […]
BSAAC hosts LGBTQ+ sports panel to foster community and conversation
On Sunday, the Bowdoin Student-Athlete Advisory Committee (BSAAC) hosted a panel with former men’s lacrosse player Ben Chadwick ’11 to increase awareness of the LGBTQ+ athlete experience. Panelists shared some of the ways they felt supported in their identities as LGBTQ+ student-athletes. Many highlighted their peers, upperclassmen and coaches. “My teammates have always provided a […]
DC Wrap: Bondi fired; Trump orders new tariffs; panel OKs ballroom plans
A look at the day's biggest stories in national politics
Federal panel packed with Trump allies approves White House ballroom project
The vote by the National Capital Planning Commission on Thursday marked the final procedural hurdle for President Donald Trump’s plans.
‘The business of health care’: Students engage with industry leaders on the future of medicine
The three panelists spoke with nearly 200 students, faculty and community members in Horrmann Library for “The Business of Health Care.”
‘The business of health care’: Students engage with industry leaders on the future of medicine
The three panelists spoke with nearly 200 students, faculty and community members in Horrmann Library for “The Business of Health Care.”
Wave of retirements and politics promise spending panel makeover
The House Appropriations Committee is set to undergo a major shake-up following the midterm elections, especially among its Republicans. With four members retiring, two running for Senate and four others in potentially tight reelection contests, nearly a third of the committee’s Republicans may not return in the next Congress. Democrats are looking at a lower […]
Trump’s White House ballroom project faces panel vote after judge ordered halt
The National Capital Planning Commission had previously delayed the vote after thousands of negative public comments
Global Climate Panel Faces Strife, Potential Funding Crunch
Major reports from the Intergovernmental Panel on Climate Change are still on track, but procedural gridlock and a looming funding shortage hint at future problems.
Local high school entrepreneurs pitch business creations at regional competition
Over 20 students from eight different CEO programs pitched their business in front of a panel of judges.
Supreme Court justices sound skeptical of Trump Administration’s effort to end automatic birthright citizenship
Daniel Radcliffe shares why his 20-year-old self 'wouldn't recognize him'
Daniel Radcliffe opened up about his mental health and the joy of fatherhood in a panel following his performance in "Every Brilliant Thing."
Student entrepreneurs compete for $67,500 at annual Business Plan Competition
$67,500 is at stake in the The University of Miami Herbert Business Schools’ annual Business Plan Competition. For 24 years, this experience has been a chance for students to gain real advice and mentorship, and pitch their business idea to a panel of experienced judges. Dr. Susan Amat, an associate professor of professional practice in
Wisconsin judicial panel dismisses Democratic attempt to redraw congressional maps
MADISON, Wis. — A three-judge panel in Wisconsin on Tuesday dismissed a lawsuit brought by Democratic voters that sought to redraw the battleground state’s Republican-friendly congressional boundary lines ahead of
Greg Gutfeld: They spent an entire weekend focused on identity politics
Fox News host Greg Gutfeld and the ‘Gutfeld!’ panel discuss Canada’s New Democratic Party handing out ‘equity cards’ to its members.
Two-Speed Multilateralism: Breaking The Deadlock On Climate And Health
As consensus fails across trade and health sectors, a vital two-speed multilateralism debate in Geneva offers hope for saving the global climate and health agenda.
Studio Display 2022 vs. Studio Display 2026 Buyer's Guide
Apple updated the Studio Display earlier this month, four years after the original launched. Here's how it compares to the original model. The new model keeps the same $1,599 starting price, 27-inch 5K panel, and overall design, but brings a handful of small internal improvements: a newer chip, upgraded Thunderbolt connectivity, Desk View camera support, and improved bass. The display itself, a 60Hz LCD panel with 600 nits of brightness, is unchanged.
Price Hike or Discount? Nintendo's Changes to Physical and Digital Game Pricing Have Analysts Split, Too
Nintendo games are about to get more expensive. Or less. Depending on whether or not you want a physical copy, and how you read its recent decision to charge different prices for physical and digital games in the U.S. What's really going on? As usual, I have turned to a panel of industry experts to explain.
This week on The V: Faith, politics and unfinished business
Panel examines faith in campaigns, Tuberville lawsuit, IVF debate and legislative priorities as Alabama's legislative session nears its end.
Apple Reportedly Planning to Launch iMac With OLED Display
Apple is preparing to launch an iMac featuring an OLED panel with higher brightness, according to ZDNet Korea. Apple has apparently requested that Samsung Display, LG Display, and other suppliers produce 24-inch OLED panel samples suitable for a future iMac model using their mass-production facilities. This would be the biggest ever OLED display offered on an Apple device.
New Chattanooga business specializes in gun safety
Ginger Chandler stood at a panel of windows overlooking a vast production floor, where a small team of workers meticulously soldered together electrical components and assembled handguns.
Solar cells just did the “impossible” with this 130% breakthrough
A new solar breakthrough may overcome a long-standing efficiency barrier. Researchers used a “spin-flip” metal complex to capture and multiply energy from sunlight through singlet fission. The result reached about 130% efficiency, meaning more energy carriers were produced than photons absorbed. This could lead to much more powerful solar panels in the future.
Bluetti’s Sora 500 solar panel is incredibly powerful for its size
The clear winner for anyone who has limited space to store an extra solar panel.
This is a 'huge' political problem for Speaker Johnson, former Biden official warns
Panelists Meghan Hays and Kaylee McGhee White analyze the congressional standoff over DHS funding on ‘America Reports.’
House ethics panel finds Florida Democratic Rep. Cherfilus-McCormick committed 25 violations
The allegations center around Cherfilus-McCormick's receipt of millions of dollars from her family's health care business after Florida made an overpayment of roughly $5 million in disaster relief funds.
House Democrat violated ethics rules, panel finds, putting her seat in jeopardy
A House Ethics Committee panel found Rep. Sheila Cherfilus-McCormick, accused of misusing covid funds, violated ethics rules. She has maintained her innocence.
Trump’s new science panel includes 9 tech billionaires—and just one scientist
There's a glaring hole in the president's new science and tech council
House ethics panel finds Florida congresswoman Cherfilus-McCormick committed 25 violations
The House Ethics Committee has found Democratic congresswoman Sheila Cherfilus-McCormick of Florida committed numerous violations of House rules and ethics standards
'That money was earned': Sheila Cherfilus-McCormick counsel pushes back on allegations of siphoning money to campaign
But a bipartisan panel of lawmakers said much of defense at House Ethics trial 'strained credibility.'
House Ethics Panel Holds Rare Public Hearing on Democrat’s Conduct
Representative Sheila Cherfilus-McCormick of Florida is charged with stealing $5 million in FEMA money for her campaign.
Cornel West speaks about ‘grim’ moment at panel on Black politics
As a part of a symposium on a new book about how accounts of the civil rights era often romanticize the movement, Cornel West, a prominent academic who ran for president in 2024, spoke at a panel with the author.
House Ethics panel declines delay for Sheila Cherfilus-McCormick's Ethics trial
The Miramar Democrat also faces criminal charges and asked Congress hold off on a verdict until her criminal trial.
Kennedy, Oz announce new health care advisory committee
The Health and Human Services Department (HHS) and Centers for Medicare and Medicaid Services (CMS) on Thursday announced the formation of a new expert advisory panel that will make recommendations…
Suffolk town supervisors, on business panel, discuss what lies ahead
Waste management, sewers, housing stock, and an expanded MacArthur airport all were topics of discussion Thursday at the HIA-LI event.
HHS convenes health care execs, motivational speaker on panel to modernize health care
The members will advise Kennedy and Oz on how to lower costs and improve care.
Legislators, business leaders highlight Texas policies driving competition with Wall Street
The panelists at the Dallas event hosted by The Texas Tribune said “Y’all Street” is poised to become the nation's financial capital.
Mike Pence To Speak At UChicago’s Institute Of Politics In April
Pence will participate in a student-moderated panel and is expected to speak about the role of the executive branch, populism and more.
Sights from SBJ’s Business of Soccer Day 1
SBJ’s Business of Soccer conference began Wednesday at Mercedes-Benz Stadium in Atlanta, starting with a panel featuring MLS Commissioner Don Garber, FIFA VP Victor Montagliani and U.S. Soccer President Cindy Parlow Cone.
Global Chemicals Science Panel Fails to Launch After Chaotic First Meeting - Center for International Environmental Law
Global chemicals science panel stalls after chaotic first meeting in Geneva, exposing political obstruction and delays in tackling toxic pollution.
Trump staffs science and technology panel with non-scientists
Appointee list is in keeping with the administration's hostility toward science.
Trump taps Mark Zuckerberg, Larry Ellison for science, tech advisory panel
A White House list of 13 appointees includes leaders from Google, Nvidia, Meta, Dell, Oracle, and Andreessen Horowitz.
Trump to name Zuckerberg, Ellison, Huang to tech panel, WSJ reports
U.S. President Donald Trump plans to appoint Meta Platforms CEO Mark Zuckerberg, Oracle Executive Chairman Larry Ellison and Nvidia CEO Jensen Huang to a panel that weighs in on AI policy and other issues, WSJ reported on Wednesday
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Your Thymus and Your Healthspan
Our thymus gland plays a central role in the development or our immune system, specifically for supporting T cell development (how these cells got their name, maturation and differentiation in the thymus) and discriminating between self and foreign, non-self antigen proteins with production of dendritic cells. As we age, our thymus gland shrinks—the process known as involution—with progressive change from spongy to fatty tissue, with loss of functionality. But this process, with respect to timeline and extent, markedly varies from one person to the next. And to make things even more complicated, our thymus gland anatomy and precise location in the chest also is highly variable. So the famous Frank Netter diagrams from the 1960s (such as at left below) don’t capture the remarkable heterogeneity that a random set of 12 chest CT scans (below at right). What I consider as 2 landmark papers in Nature this week (here and here) used AI to quantify health of the thymus in 2 large cohorts, and then correlate the metric to a broad array of health outcomes. In this edition of Ground Truths, I’m going to cover three questions: (1) How was thymus health determined by AI?; (2) How is thymus health linked to key clinical outcomes? and (3) Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? Subscribe 1. How was thymus health determined by AI? This was accomplished by extensive work developing and validating an AI pipeline for 2 stages, the first for localization and segmentation of the thymus bed, and the second to quantify a digital marker, termed the thymic health score. There’s a lot to this algorithmic development, so I won’t go into all the details, but just provide a rudimentary outline of what was done. The 1st stage used supervised learning with 2 radiologists reviewing 2,461 chest CT scans. That work trained a 3D U-Net model to automatically identify the thymic bed’s 3D cropped region using center of mass coordinates, which reached 99.8% accuracy. The 2nd stage used a foundation model that was pre-trained with SwAV (which stands for Swapping Assignment between multiple Views), a self-supervised model, that generated a high-dimensional thymus representation of 4,096 features. That compares to the radiology reductionist and subjective scoring of 0 to 3 where 0 means the thymus is fully degenerated and fatty, and 3 is considered dense, intact glandular soft tissue. Notably, the self-supervised learning (SSL) performance was superior to supervised (AUC ~0.75 vs 0.55, respectively) reflecting the shallowness of the 0-3 classifier vs SSL’s holistic, self-taught AI. The thymic health score ranged from 0 to 100, with the highest number indexed to fully preserved thymic health. The algorithmic work extended to explainability with both Shapely value distribution, meaning the model was holistic not relying on any “magic” pixel, and occlusion sensitivity, demonstrating the model’s performance was not affected by ribs, sternum, lung tissue, but rather focused on the thymic bed directly. Below are a few saliency maps from the occlusion sensitivity that indicate the thymic bed focus, not affected by neighboring structures, using the jet color scale. Now the AI was ready for processing ~25,000 CT scans, each over 30 MB files, from the 2 large participant cohorts to provide a thymic health score, it did so in less than 14 hours, which is less than 2 seconds per scan! Share 2. How is thymus health linked to key clinical outcomes? The two cohorts were the National Lung Screening Trial, NLST (N=25,031) and the Framingham Heart Study, FHS (N=2,581) each with baseline demographics and long term follow up of >12 years for health outcomes. From the NSLT, you can see below that increased age and body-mass index were correlated to reduced thymic health. And, overall, men had reduced thymic health scores compared with women. There are a lot of graphs in the paper for outcomes, for both the NLST and FHS cohorts. To simplify the major outcomes, below is a composite Figure with striking reduction of all-cause mortality and for the different causes of death. The results were consistent between the 2 cohorts. For example, the cardiovascular mortality hazard ratio average was 0.57 in NLST and 0.38 in FHS (weighted to be 0.53 for the aggregate). The reduction of mortality also extended to digestive diseases and pulmonary disease (data not shown below). Lung cancer incidence was reduced by 36% for high vs low thymic health (Figure below, with a panel -incidence and b panel-mortality, adjusted for age, sex, BMI, smoking status). Notably, there was a smoker’s paradox: lower incidence and improved survival for lung cancer in smokers who had a high thymus health score. Smoking was associated with lower thymic scores whereas alcohol was not. Higher thymic health was linked to higher HDL cholesterol, lower triglycerides, lower fasting blood glucose, and lower systolic and diastolic blood pressure. Inflammation biomarkers, such as C-reactive protein and interleukin-6, were elevated in the people with lower thymic health scores. In their second paper, the same team looked at the relationship between thymic score and outcomes for 3,476 patients receiving cancer immunotherapy. The non-small cell lung cancer progression-free survival was reduced in patients with low thymic health score. A parallel relationship for survival was seen for other types of cancer including melanoma, breast, and kidney with a 44% lower risk among high thymic scores (Figure). A similar pattern was seen with different immune checkpoint inhibitors. The thymus health score outperformed programmed death ligand-1 (PD-L1)and tumor mutation burden (TMB) assay of the tumor and was an independent prognostic marker of progression-free survival. In this dataset, a direct connect with thymus score and adaptive immune function was noted with a correlation before cancer treatment for both T-cell diversity and thymus T-cell production (a metric known as T cell receptor excision circles). Thymus Removal Study There is a highly relevant citation about thymus function before moving onto ways to rejuvenate it. In 2023, a very important study of thymus removal during cardiothoracic surgery was published, with 1146 patients undergoing thymus removal vs 1146 matched controls (mean age 55 years). The adverse outcomes for thymus removal were striking, with a 2.9 higher risk of all-cause mortality and doubling of cancer incidence, 1.5 fold increase in cancer mortality, and 1.5-fold increase in autoimmune diseases. The immune function showed marked compromise after thymus removal, as reflected by CD4+ and CD8+ T cells (Figure below) Share Ground Truths 3. Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? In recent months we’ve learned a lot about the process of thymus involution and the pathways by which this may be modulated. Thymus involution is primarily due to loss to thymus epithelial cells (TECs) and there are 2 subtypes with different functions: the cortical, responsible for positive selection of T cells, and the medullary, for negative selection. When adipose tissue infiltrates the thymus, thymic adipocytes are pro-inflammatory, knocking out T-cell output. Likewise, systemic inflammation, or “inflammaging,” from smoking, obesity, and chronic stress promote thymic adipocytes. Now, from preclinical studies, we know about key pathways that account for these processes. Historically, back in 2014, FOXN1 was recognized as a single master transcription factor essential for TEC function, with studies in mice with forced FOXN1 upregulation leading to thymus regeneration. That laid the foundation for potential regrowth of quiescent thymus cells. It took awhile to find pathways to accomplish this goal and to even refute its role as the master regulator. The Liver-Thymus Axis Feng Zhang and his team recently showed that injection of an mRNA vaccine to the liver encoding DLL1, IL-7 and FLT3-L in combination, factors known to support thymopoiesis (Figure), successfully enhanced immune function in aged mice. However, the effect was transient. The FGF21 Story Two reports in 2025 addressed the thymus gland’s production of FGF21, a growth factor (fibroblast growth factor 21) and its control of thymus involution. This growth factor is also produced by the liver, but it doesn’t have impact on the thymus in aged rodent models. In contrast, The liver’s hepatocyte growth factor (HGF) has been shown to reverse senescent TEC structural changes. Growth hormone stimulates production of insulin growth factor-1 (IGF-1) in the liver and the thymus. Two small studies in human participants (TRIIM, for Thymus Regeneration, Immunorestoration, and Insulin Mitigation) of 6 and 50 people, respectively, treated with combined human growth hormone, metformin and DHEA, suggested the potential of slowing epigenetic aging and improving thymus mass and function. But the combination of drugs, small sample, and lack of controls make conclusions murky. Increased thymus FGF21 led to increased CD8 T cells in old mice and extended healthspan and improved physical performance. Building on the previous FOXN1 data, ablation of β-klotho, the obligatory co-receptor for FOXN1, accelerated thymic aging. The benefit to FGF21 was confirmed in a companion paper using an FGF21 knock-in mouse model showing thymus enlargement and increased TECs throughout the lifespan. (schematic Figure below). The accompanying editorial for these 2 papers speculated: “The proposed link between age-associated thymus involution and organismal aging is intriguing, and suggests we might seek to achieve systemic rejuvenation by counteracting thymic involution.” Other Factors Lessons from the Axolotl (Mexican Salamander) In an elegant set of experiments of the axolotl (Figure), known for its complete thymus regeneration after total surgical removal, mediators were identified. Surprisingly FOXN1 was dispensable. But midkine, a growth factor, appeared to be the driver, the initiator of thymus cell growth, survival, and repair. Other components that contributed were Postn+ (periostin-expressing mesenchymal niches) and Ccl19, a chemokine protein from the bloodstream. RANK and RANKL RANK (receptor activator of nuclear factor κB its ligand (RANKL) have been considered key regulators of medullary TECs. In a study of both aged mice and human thymus cell cultures, their key role was confirmed, with multiple benefits of resorting TEC function, recruitment of progenitor cells, and T cell development. Subscribe Summing Up This body of work strongly supports the health of the thymus gland as a critical regulator of human healthspan, not just a correlate or link. The new landmark studies are reinforced by the regenerative biology experimental models that have shown, via an array of mediators, that healthspan of aged mice is at least in part dependent on thymus gland function and its critical role for maintaining adaptive immunity. It sure seems that we’d be better off having an immune reservoir of naive T cells instead of a profile in older adults of exhausted, low quality, memory T cells, with a senescent phenotype. It is striking that we ignored the importance of the thymus gland for many decades. A wake-up call was the results of the thymectomy matched control study reviewed here, with the opposite of high thymic health score improved health outcomes. The convergence of AI and healthspan here is notable. The exceptional and laborious work for developing and validating (no less explaining) the AI to quantify thymus health set the foundation for probing the connect the major health outcomes in two cohorts with extensive follow-up. We’ve never had a way to meaningfully quantify the thymus gland before, so this represents important leverage of supervised, self-supervised, and transformer models. The study wouldn’t have been possible without AI. And it begs the question as to whether there are ways we can maintain our thymus at a high health score. But it’s not so simple to rejuvenate our thymus. There are multiple risks including the induction of autoimmunity, increasing the risk of cancer, and inducing a pro-inflammatory state. For example, factors that increase TEC proliferation could compromise the medulllary negative selection process and leak out auto-reactive (self-attacking) T cells. Thymic cells could be induced to proliferate, but we know, for example, that growth hormone and IGF-1 are associated with an increase risk of cancer. If thymus rejuvenation doesn’t clear out the accumulated senescent cells in older adults, then inflammation within the gland could block the production of TECs. Keeping these risks in mind, we now have identified many ways to keep our thymus healthy as we age that undoubtedly will be tested in clinical trials going forward. Ultimately, the benefit-to-risk tradeoffs will be defined. In the meantime, we have desperately needed an immunome. As I’ve stressed in multiple prior Ground Truths, we have no test in the clinic to assess a patient’s immune status! It was very encouraging for me to get an email from Hugo Aerts, the senior author of the landmark papers in the days after they were published: “I also wanted to say that your Substack on “Why We Need an Immunome” was inspiring for this work. We found it a very compelling perspective and greatly enjoyed reading it.” Just having an assessment of a person’s immune status via a chest CT scan, with millions of these performed per year, might help in guiding the right immunotherapy for cancer (e.g. more intensive, combinations for those with low thymic health scores) and help define people who are increased risk for age-related diseases of cancer, cardiovascular, and neurodegenerative. The main theme of Super Agers is that we now have many layers of data (genetics, proteins, biomarkers, organ clocks that can be integrated via multimodal AI) for us to define a person’s specific risk decades before one of these age-related diseases leads to symptoms, enabling prevention. From the new studies this week, we can add thymus health score as yet another way to understand a person’s risk, a window into their adaptive immune system and healthspan. And perhaps someday we will be able to safely rejuvenate the thymus, or maintain its health through one’s life, and use the thymus health score to monitor. NB: I wrote this post (No A.I.) A Quick Poll Loading... ********************************************************************* Thanks to Ground Truths subscribers (now > 200,000) from every US state and 212 countries. Your subscription to these free essays and podcasts makes my work in putting them together worthwhile. Please join! If you found this interesting PLEASE share it! Share Ground Truths Paid subscriptions are voluntary and all proceeds from them go to support Scripps Research. They do allow for posting comments and questions, which I do my best to respond to. Please don’t hesitate to post comments and give me feedback. Let me know topics that you would like to see covered. Leave a comment Many thanks to those who have contributed—they have greatly helped fund our summer internship programs for the past two years. It enabled us to accept and support 47 summer interns in 2025! We aim to accept even more of the several thousand who will apply for summer 2026.
Oscar-Winning Alumnus Returns to Pasadena’s ArtCenter for Entertainment Design Expo
One week after winning the Academy Award for Best Animated Feature, KPop Demon Hunters co-director Chris Appelhans returns today to ArtCenter College of Design, the Pasadena campus where he studied illustration, for the college’s third annual Entertainment Design Expo. The expo, known as ENTX, opens the Hillside Campus to the public for a full day of gallery exhibitions, game playtesting, animation screenings and interactive experiences featuring work from more than 200 ArtCenter students and alumni. General admission is free with advance registration. Two industry panels — including Appelhans’s talk — require $15 tickets. Appelhans, who graduated from ArtCenter with a bachelor of fine arts in 2002, co-directed KPop Demon Hunters with Maggie Kang. The animated film, produced by Sony Pictures Animation and released on Netflix, became the streaming platform’s most-watched film in history, according to Netflix, and swept awards season with wins at the Golden Globes, the Annie Awards and the Grammys before taking the Oscar on March 15. His talk and audience Q&A is scheduled from noon to 1 p.m. in the Ahmanson Auditorium. Doors open at 11:30 a.m. The film’s ArtCenter ties extend beyond its co-director. Art director Angela Sung, cinematographer Gary H. Lee, visual development artist Celine Kim and painter Simon Baek are all ArtCenter graduates who worked on the production, according to the college. The free portions of ENTX include a concept design showcase, a production design gallery, a model gallery, a stop motion studio preview, an alumni gallery and a KPop Demon Hunters fan art gallery. Visitors can also playtest games designed by ArtCenter students. An Animation Shorts Showcase runs from 2 to 3 p.m. and includes “Boy, I’m Scared,” a capstone short by ArtCenter graduate Lindsey Tenaglia that was named a semifinalist for the 2025 Student Academy Awards in the animation category. Also screening