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Exposome Signature: A multi‑system view of human adaptation to spaceflight

Spaceflight is extremely challenging for both body and mind. Astronauts experience a combination of stressors – microgravity, radiation, confinement, isolation, circadian disruption and environmental changes – that can trigger physiological responses resembling those seen on Earth in chronic diseases and accelerated aging. One characteristic effect is low‑grade inflammation (LGI), a subtle and persistent activation of the immune system.

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Oct 23 • 8:00 AM EDT • Science • esa.int
Why Rochester Hills businesses are fighting a $40M road project -- and it’s not the construction
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Oct 23 • 7:53 AM EDT • Business • clickondetroit.com
GuliKit TT Pro review: The ideal Switch 2 controller for players on the go

A protective case and an accessory box make it easy to travel with the TT Pro.

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Oct 23 • 7:30 AM EDT • Technology • engadget.com
3 Quick Exercises to Do Daily to Build Bone and Muscle Health Mid-Life, According to a Longevity Expert

In TODAY.com’s Expert Tip of the Day, Dr. Vonda Wright, orthopedic surgeon and longevity expert, shares three movements to integrate into your daily routine to help you age better.

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Oct 23 • 7:23 AM EDT • Health • today.com
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Moderna Named a Top Employer by Science for Twelfth Consecutive Year

CAMBRIDGE, MA / ACCESS Newswire / October 23, 2026 / Moderna, Inc. (NASDAQ:MRNA) today announced it was ranked as a top employer in the global biopharmaceutical industry in Science and

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Oct 23 • 7:01 AM EDT • Science • newspressnow.com
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Gasperini requests two signings in January

January is approaching, when the transfer window reopens, and Gasperini is asking Roma for reinforcements. Sporting director D’Amico has confirmed that something will likely happen. According to Tut...

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Oct 23 • 7:01 AM EDT • Sports • sports.yahoo.com
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Large businesses’ cybersecurity insurance claims are now less frequent but more expensive

AI-powered attacks and hidden supply-chain weaknesses are making insurers’ work more difficult, according to a new report.

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Oct 23 • 6:41 AM EDT • Business • cybersecuritydive.com
Does technology liberate you or enslave you?

When you can organize and manage things properly, it’s amazing how much you can accomplish without living at work

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Oct 23 • 6:27 AM EDT • Business • nhbr.com
Your iPhone Duo Is a Big Investment—Here’s How To Keep It Protected and Powered, Anywhere

If you're buying Apple's first foldable, you need the best accessories for it.

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Oct 23 • 6:20 AM EDT • Technology • gizmodo.com
Irish state agency rolls out seafood advisory program, connecting businesses with expert consultants

Bord Iascaigh Mhara (BIM) recently rolled out the Seafood Business Advisory Program, providing Irish seafood firms with access to external experts.

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Oct 23 • 5:30 AM EDT • Business • seafoodsource.com
Scientists Discover a Hidden Oxygen Source Deep Inside Earth That Could Rewrite Our Planet’s History

Ancient eruptions may have helped shape the air we breathe, with laboratory experiments revealing magma’s unexpected ability to store extra oxygen. Molten rock deep inside Earth can take up an extra supply of oxygen under pressure, according to a new study. That finding raises the possibility that rising magma could release oxygen on its way

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Oct 23 • 5:21 AM EDT • Science • scitechdaily.com
Access Health CT open enrollment begins

Open enrollment for Access Health CT, the state’s official marketplace for Affordable Care Act coverage, is open now through Jan. 15.

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Oct 23 • 5:04 AM EDT • Health • wfsb.com
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This Philly health advocate is breaking barriers to care

Following a long wait for a kidney transplant, scholar and advocate Jazmin Evans now works to make healthcare more accessible for others.

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Oct 23 • 5:00 AM EDT • Health • spotlightpa.org
Kansas manufacturing business responds to candidates’ conflicting accounts of tariff effects

KANSAS CITY, Mo. — The two major party candidates for U.S. Senate diverged in a debate Wednesday night on whether tariffs were helping or hurting a Salina manufacturing business they both visited. A spokesperson for the business, however, denied U.S. Sen. Roger Marshall’s claim that tariffs were contributing to its growth. Tim Henry, chief financial […]

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Oct 23 • 4:50 AM EDT • Business • kansasreflector.com
Infographic: Top Business Challenges in Canadian Promo

Concerns remained the same in 2025 and 2026, according to new data from ASI Research, and worries about recruiting and retaining well-qualified workers ticked back up this year.

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Oct 23 • 4:30 AM EDT • Business • members.asicentral.com
LeBron James: Donald Trump accuses Philadelphia 76ers star of moving during national anthem before NBA season opener

President Donald Trump has accused LeBron James of disrespecting the United States after the star continued warming up during the national anthem; watch the 2026/27 NBA season, including the Christmas Day games and the NBA finals, only on Sky Sports.

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Oct 23 • 2:51 AM EDT • Sports • skysports.com
Luther Burden III leads the way with 130 yards receiving

Luther Burden III had a game-high 130 yards and a touchdown on just four receptions on Thursday Night Football versus the Pats.

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Oct 23 • 2:20 AM EDT • Sports • sports.yahoo.com
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Giorgia Meloni is Italy’s great political survivor. Could one man be about to bring her down?

With elections looming in 2027, Roberto Vannacci’s new far-right movement could fatally outflank the prime minister, says Riccardo Alcaro, head of research at Istituto Affari Internazionali

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Oct 23 • 12:00 AM EDT • Politics • theguardian.com
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Steelers climb AFC playoff standings after Bears defeat Patriots

Steelers climb playoff standings after Patriots’ loss to Bears.

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Oct 22 • 11:42 PM EDT • Sports • sports.yahoo.com
Giants’ strong special teams unit has one big weakness: counting

One of the best special teams units in the NFL can’t keep getting burned by something as simple as counting to 11.

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Oct 22 • 11:30 PM EDT • Sports • sports.yahoo.com
Capcom Data Breach Results In Unauthorised Access To More Than 11.7 Million 'CAPCOM ID' Accounts

"We would like to sincerely apologize"

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Oct 22 • 11:30 PM EDT • Technology • nintendolife.com
Middle East Conflict Puts F1’s Season Finale at Risk

F1 assures that Qatar and Abu Dhabi will be held according to the calendar, but it has already activated a contingency plan with Imola as an alternative venue.

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Oct 22 • 11:09 PM EDT • Sports • sports.yahoo.com
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RFK Jr., Dr. Oz visit Broward Health to outline new federal Alzheimer's initiative

The FDA program's first initiative, the Alzheimer's Prevention Accelerator, focuses on finding medical products that can help delay or altogether prevent Alzheimer's disease and related dementias.

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Oct 22 • 10:15 PM EDT • Health • wusf.org
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Downtown Sacramento businesses prepare for crowds ahead of Kings home opener

A new team store, Kings-themed drinks and game-day discounts are among the offerings available to fans near Golden 1 Center.

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Oct 22 • 10:02 PM EDT • Business • kcra.com
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Rashee Rice unable to practice

Kansas City Chiefs WR Rashee Rice remains sidelined Thursday

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Oct 22 • 9:48 PM EDT • Sports • sports.yahoo.com
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Flu cases rise on west coast earlier than usual as US officials encourage vaccine

California flu test rate at 9.65%, higher than normal 1% rate for early October, amid mutation of H1N1 influenza A strain

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Oct 22 • 9:44 PM EDT • Health • theguardian.com
Advancing Women's Health Through Collaboration, Innovation and Entrepreneurship - Small Business & Entrepreneurship Council

White House initiative connects government, researchers, and private-sector innovators to accelerate discoveries and improve women’s health outcomes. By Karen Kerrigan – On October 19, I had the opportunity to attend the White House signing ceremony for President Donald Trump’s executive order, Advancing Women’s Health to Improve Outcomes in All Phases of Life, an initiative championed […]

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Oct 22 • 9:33 PM EDT • Health • sbecouncil.org
Advancing Women's Health Through Collaboration, Innovation and Entrepreneurship - Small Business & Entrepreneurship Council

White House initiative connects government, researchers, and private-sector innovators to accelerate discoveries and improve women’s health outcomes. By Karen Kerrigan – On October 19, I had the opportunity to attend the White House signing ceremony for President Donald Trump’s executive order, Advancing Women’s Health to Improve Outcomes in All Phases of Life, an initiative championed […]

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Oct 22 • 9:33 PM EDT • Business • sbecouncil.org
Meriden tax business owner accused of filing 4,335 fraudulent returns

Prosecutors said many of the tax returns included fraudulent deductions.

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Oct 22 • 9:05 PM EDT • Business • ctinsider.com
Former Vice President Harris joins campaign trail to hear rural healthcare concerns

Former Vice President Kamala Harris joined U.S. Senate candidate Scott Colom and Mississippi health care providers in Clarksdale to hear how limited access to care is affecting rural families.

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Oct 22 • 8:46 PM EDT • Health • actionnews5.com
Chemistry is Everywhere: Students Discover the Science Behind Everyday Life

Chemistry is Everywhere: Students Discover the Science Behind Everyday Life

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Oct 22 • 8:37 PM EDT • Science • princewilliamliving.com
50 Cent allegedly bailed out suspect accused of assaulting Rick Ross' son

50 Cent allegedly bailed out a 20-year-old man identified in police filings as Don Roberts, who is accused of pistol-whipping Rick Ross’ son, 21-year-old William Roberts III. The two rappers have been feuding since the late 2000s.

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Oct 22 • 8:24 PM EDT • Entertainment • latimes.com
Breakthrough vaccine for the deadliest skin cancer cut risk by almost half

The skin cancer vaccine is based on mRNA technology that helped end the coronavirus pandemic.

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Oct 22 • 8:24 PM EDT • Health • washingtonpost.com
Acupuncture and mutual exchange in Chinese and Soviet science

Previous accounts of the scientific relationship between communist China and the Soviet Union have depicted it as one of subordination, with the Russians exporting knowledge to the Chinese or scavenging ...

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Oct 22 • 8:00 PM EDT • Science • phys.org
Dental implants can hijack your immune system, scientists discover

Researchers have uncovered a surprising reason dental implant infections often resist antibiotics: the implants themselves can contribute to the problem. Bacteria corrode titanium implants, releasing microscopic particles that hijack immune cells, trigger destructive inflammation, and accelerate jawbone loss.

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Oct 22 • 8:00 PM EDT • Science • sciencedaily.com
One of Earth’s most powerful supervolcanoes is refilling with fresh magma

Deep beneath Japan’s Kikai caldera, a massive magma reservoir is refilling 7,300 years after one of the most powerful volcanic eruptions in Earth's recent geological history. Scientists used underwater seismic surveys to reveal a vast store of magma that appears to have accumulated since the ancient catastrophe. The discovery could help explain how supervolcanoes like Yellowstone and Toba rebuild their magma supplies.

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Oct 22 • 8:00 PM EDT • Science • sciencedaily.com
Withings and Function Integrate Connected Health Data with Comprehensive Lab Testing

Withings and Function have announced a partnership integrating connected health device measurements with comprehensive laboratory testing, enabling users to access daily biometric data and clinical results through both companies’ digital platforms. The integration aims to provide a more continuous view of individual health by combining routine measurements with periodic laboratory assessments.Under the agreement, Function members can synchronize data from Withings devices directly into the Function app, including body com...

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Oct 22 • 8:00 PM EDT • Health • hlth.com
The business case for pro bono: indirect benefits with social impact

Pro bono work has evolved into a driving force within Argentina’s legal profession, expanding access to justice while strengthening law firms, lawyers and civil society organisations. Through collaboration and institutional commitment, it has become a powerful tool for talent development, reputation building and long-term impact.

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Oct 22 • 8:00 PM EDT • Business • latinlawyer.com
Virginia state senator accused of shielding marijuana business

Fox News chief Washington correspondent Mike Emanuel reports on the federal indictment against state Sen. L. Louise Lucas, D-Va., on ‘Special Report.’

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Oct 22 • 7:26 PM EDT • Business • foxnews.com
George Pickens a limited participant Thursday

Cowboys WR George Pickens dealing with shoulder issue and listed as limited

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Oct 22 • 6:22 PM EDT • Sports • sports.yahoo.com
Quest Diagnostics confirms patient information accessed in cyberattack, systems temporarily shut down

Quest Diagnostics temporarily suspended access to several systems following a cyberattack involving patient information.

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Oct 22 • 6:13 PM EDT • Business • foxbusiness.com
Refusal of Care Laws: A Threat to Both Patient Health and States’ Protection of Abortion Access

What You Can Do To Put Patients First In Your State Across the country, people are being denied the health care they want or need, not for medical or professional reasons, but because of the personal beliefs of the health care provider or the institution’s affiliation. Denials range from abortion care (including miscarriage care), to […]

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Oct 22 • 6:10 PM EDT • Health • nwlc.org
SF: Health Officials To Discuss Recent Mgm-15 Related Overdose

San Francisco public health officials plan to release the city's latest data on accidental overdoses on Friday and also discuss a recent death linked to the kratom-derived opioid MGM-15.

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Oct 22 • 6:07 PM EDT • Health • sfgate.com
Petition grows as Rochester Hills businesses fight Rochester Road construction traffic plan
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Oct 22 • 5:36 PM EDT • Business • clickondetroit.com
Ethics complaint filed against Rep. Derrick Van Orden for AI use

EAU CLAIRE, Wis. (WQOW) -- An ethics complaint has been filed against Rep. Derrick Van Orden with the Wisconsin Ethics Commission, accusing him of posting an AI-generated image of Rebecca

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Oct 22 • 5:05 PM EDT • Politics • wqow.com
Tiffany announces parental 'Bill of Rights' to ban transgender sports, pronoun changes

Republican candidate for governor Tom Tiffany says he’ll make Wisconsin schools more accountable by giving parents and teachers more rights.

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Oct 22 • 4:32 PM EDT • Sports • wpr.org
Wyoming Business Council Seeking Interim CEO

The Wyoming Business Council Board of Directors has announced they are accepting applications for an interim chief executive officer following the departure of Josh Dorrell, who led the agency for seven years. According to a news release, this appointment is expected to last approximately nine to 12 months while the board prepares to recruit a […]

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Oct 22 • 4:27 PM EDT • Business • sheridanmedia.com
Capcom confirms data breach affecting 11.7 million accounts

Japanese gaming giant Capcom has confirmed that hackers breached its membership service, CAPCOM ID, exposing more than 11.7 million customer email addresses and associated information.

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Oct 22 • 4:22 PM EDT • Technology • bleepingcomputer.com
Premiums for Employer-Sponsored Family Health Coverage Top $28,000 in 2026

Workers are paying on average $7,471 annually toward the premiums for employer-sponsored family health benefits this year, which is up 9%, or $621, from 2025, according to KFF’s annual benchmark health benefits survey of large and small employers.

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Oct 22 • 4:12 PM EDT • Health • kff.org
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Redesign Health, ARC Global merge in $2B deal to accelerate health system innovation

Redesign Health is making a major push deeper into health system-led innovation, merging with Sheba Medical Center’s innovation arm ARC Global. | The three organizations—Redesign Health, ARC Global and AVIA—work with more than 100 health systems on five continents, and the companies and products built across their networks have reached more than 100 million patients worldwide.

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Oct 22 • 4:00 PM EDT • Health • fiercehealthcare.com
Big Sky students get a head start on business through International Baccalaureate Program

Two-year course challenges juniors and seniors to analyze real companies, explore business strategy and develop critical thinking skills By Leslie

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Oct 22 • 3:57 PM EDT • Business • explorebigsky.com
Cone Health to acquire three Reidsville pharmacies

Cone Health is acquiring three pharmacies in Reidsville with the hopes of expanding affordable access, onsite vaccinations and continuing community-based care.

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Oct 22 • 3:37 PM EDT • Health • wxii12.com
Crows may make lightning-fast decisions, sometimes twice as fast as humans, study hints

Carrion crows made decisions about their visual environments significantly faster than humans and primates tend to, according to a comparison in a new study.

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Oct 22 • 3:34 PM EDT • Science • livescience.com
Tom Skerritt, star of ‘Alien’ and familiar face at SIFF, dies at 93

Tom Skerritt, the acclaimed character actor who starred in “Alien,” “Top Gun,” “Contact” and more, died Wednesday at his home in Seattle. He was 93.

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Oct 22 • 3:33 PM EDT • Entertainment • seattletimes.com
Cost of employer-sponsored health insurance plans rises again, nonpartisan survey finds

The price health insurance companies charge for employer-sponsored plans increased again this year, as did the deductible many people must pay before those plans begin covering most healthcare costs, according to a survey released Thursday by the nonpartisan health organization KFF.

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Oct 22 • 3:18 PM EDT • Health • kcrg.com
Microsoft Diagnostic AI Outperforms Generalist Physicians in Science Study

Microsoft's MAI-DxO diagnostic system outperformed participating generalist physicians on complex diagnostic cases in a peer-reviewed study published October 22, 2026 in Science, which reported 83.2% accuracy for the sys...

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Oct 22 • 3:13 PM EDT • Science • unite.ai
1Password launches a way for AI agents to log in on your behalf without seeing your password

The new feature allows agents to log into a customer's personal accounts while still protecting the private credentials that secure those accounts.

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Oct 22 • 3:07 PM EDT • Technology • techcrunch.com
Burk begins term as Virginia Municipal League president

Leesburg Mayor Kelly Burk is the new president of the Virginia Municipal League board of directors, according to a news release.

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Oct 22 • 3:01 PM EDT • Politics • loudountimes.com
Endeavor Heartland names fall accelerator participants

Bentonville-based Endeavor Heartland recently named eight companies to participate in its fall 2026 ScaleUp Accelerator. The program is supported by the Walton Family Foundation and the Arkansas Economic Development Commission....

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Oct 22 • 2:55 PM EDT • Politics • talkbusiness.net
Endeavor Heartland names fall accelerator participants

Bentonville-based Endeavor Heartland recently named eight companies to participate in its fall 2026 ScaleUp Accelerator. The program is supported by the Walton Family Foundation and the Arkansas Economic Development Commission....

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Oct 22 • 2:55 PM EDT • Business • talkbusiness.net
Giant iPhone Duo Displays Coming to Four Apple Stores

To celebrate the launch of the iPhone Duo this Friday, Apple has set up oversized iPhone Duo promotional displays at Apple Fifth Avenue in New York City, Apple Covent Garden in London, Apple BKC in India, and Apple Jing'an in Shanghai. The installations were already spotted under wraps, and Apple CEO John Ternus has since revealed what they look like in a photo of Apple Jing'an shared on his Weibo account today.

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Oct 22 • 2:50 PM EDT • Technology • macrumors.com
'Today's' Craig Melvin crowned People's sexiest morning show host

'Today' co-anchor Craig Melvin reluctantly accepts the crown for sexiest morning show host in People's Readers' Choice Poll.

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Oct 22 • 2:45 PM EDT • Entertainment • latimes.com
Lawsuit accuses Trump of illegally profiting from UAE crypto investments

The lawsuit claims the investments violate the Constitution’s foreign emoluments clause

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Oct 22 • 2:45 PM EDT • Politics • spectrumlocalnews.com
Microsoft’s Mustafa Suleyman says its AI outperforms doctors on hard cases as he chases ‘medical superintelligence’

Microsoft’s new AI diagnostic system beat generalist doctors on hard cases, according to a study in Science. But most of the improvement seems to come from the AI models underneath, not from Microsoft’s system itself.

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Oct 22 • 2:43 PM EDT • Technology • techcrunch.com
Eagles to release E.J. Jenkins ahead of Cowboys matchup

The Eagles are releasing E.J. Jenkins, according to Mike Garafolo. The tight end appeared in all six games this season, making two starts

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Oct 22 • 2:36 PM EDT • Sports • sports.yahoo.com
County BZA approvals permit poultry, business expansions

Wayne County Board of Zoning Appeals approved five petitions — two requesting additions for ag businesses, another seeking acreage reduction for poultry, a mining business expanding its property and a chiropractor moving his operations locally — at its Oct. 8 meeting. Hally Jordan and James Spears’ petition to reduce minimum lot acreage to accommodate 14 […]

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Oct 22 • 2:30 PM EDT • Business • westernwaynenews.com
Kristin Dietzel focuses on business growth, access in run for Dubuque County supervisor

Watch KCRG-TV9's full interview with Democratic candidate for Dubuque County supervisor Kristin Dietzel from October 2026.

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Oct 22 • 2:25 PM EDT • Business • kcrg.com
Feds allege $2 billion in California health care fraud, 15 charged

Federal authorities announced charges against 15 people, including six medical professionals, accusing them of health care fraud schemes worth $2 billion, including sham substance abuse treatment programs, unnecessary medical procedures and bogus hospice services.

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Oct 22 • 2:14 PM EDT • Health • latimes.com
Lawsuit accuses Trump of illegally profiting from UAE crypto investments

The lawsuit claims the investments violate the Constitution’s foreign emoluments clause

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Oct 22 • 2:12 PM EDT • Politics • spectrumlocalnews.com
Health Sciences and Marine & Environmental Sciences Programs Launch In

A new University of New Haven initiative brings together Health Sciences and Marine & Environmental Sciences faculty to advance accessible science education, inclusive learning, and community-engaged

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Oct 22 • 2:07 PM EDT • Science • newhaven.edu
Amazon renames Kindle Unlimited to Kindle Plus and expands access to audiobooks

Kindle Unlimited is now Kindle Plus.

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Oct 22 • 1:46 PM EDT • Technology • theverge.com
Jamilia Sherls, on where health systems should turn for vaccine guidance
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Oct 22 • 1:41 PM EDT • Health • managedhealthcareexecutive.com
Small business optimism dips in September NFIB survey

Small business optimism slipped in September as owners grappled with rising costs, higher interest rates and a persistent shortage of qualified workers, according to a monthly survey released by the National Federation of Independent Business. The NFIB Small Business Optimism Index fell 0.8 points to 97.9, just below the survey’s 52-year average of 98.0. The […]

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Oct 22 • 1:11 PM EDT • Business • quadcitiesbusiness.com
How well have past GOTY winners sold?

We’re less than two months away from 2026’s The Game Awards, and what a year it’s been for fantastic games, including Resident Evil Requiem, Forza Horizon 6, Slay the Spire II, the Blood of Dawnwalker, and Control Resonant – just to name a few. So as we approach the end of the year, we thought we’d look back on our estimates for the GOTY winners of the past four years. In terms of revenue, Elden Ring (2022 winner), Baldur’s Gate 3 (2023), Astro Bot (2024), and Expedition 33 (2025) have generated a combined $3.8B via 73M copies sold: Let’s have a look, then. Elden Ring has generated $2B in revenue Elden Ring is a phenomenon in every sense. It’s sold a whopping 36.4M copies across Steam (50%), PS5 (35%), and Xbox (15% across console and PC). Want more free estimates and insights in your inbox twice a week? Subscribe below! Subscribe Elden Ring also just passed an astronomical milestone: $2B in revenue. While PlayStation and Xbox account for half of Elden Ring’s copies sold across these three platforms, they account for 57.5% of revenue. This – as ever – is due to regional pricing and the higher relative share of PC gamers in lower-priced markets. For example, around 17.4% of Elden Ring’s Steam copies sold were in China, where the game costs about 26% less than the price in the States. There’s an … interesting narrative going around these days that console gamers are only interested in ball-and-gun games and have the patience for little else. Well, Elden Ring’s impressive sales prove that is simply not true, and across all platforms. What’s more, over 9.8M people have played Elden Ring for over 100 hours, with nearly 3.5M people getting all of the achievements and trophies. For reference, 10.9% of Elden Ring’s PlayStation players have the platinum trophy, while 10.5% of players on Steam and 3.9% of Xbox players unlocked all the achievements. Git gud, Xbox players! Of the 1.5M people who played Elden Ring on PlayStation last month, 4% also played Dark Souls 3 last month, 4% played Bloodborne, and 3% played Sekiro. There’s those Soulsborne diehards for you. By many accounts, including my own, Elden Ring is one of the best games of all time. It’s an evergreen seller that will continue to be a cash cow for Bandai and FromSoftware for years to come. Want more free estimates and insights in your inbox twice a week? Subscribe below! Subscribe Elden Ring has sold another 2M copies across Steam, PlayStation, and Xbox this year, generating almost $110M. This means it’s outperforming many of this year’s high-profile releases. Even Elden Ring’s standalone run-based PvE spinoff, 2025’s Nightreign, has sold 7.8M copies and generated $282M in revenue. Baldur’s Gate 3 is another billion-dollar-plus banger Another cross-platform phenomenon is Baldur’s Gate 3, which has sold 23.2M copies and generated over $1.2B in revenue. About 18.7M of these copies (80.6%) are via Steam, 2.9M via PS5 (12.7%), and 1.6M (6.8%) via Xbox. Around 1.3M folks on Steam bought BG3 before it hit 1.0. The PlayStation version launched about a month after the PC 1.0 release, while the Xbox version came four months later due to technical issues around developing local co-op on the Series S. Want more free estimates and insights in your inbox twice a week? Subscribe below! Subscribe Across platforms, Baldur’s Gate 3’s monthly active users have never dropped below 2M, including 2.2M MAUs last month (68.5% on Steam, 21.9% on PS5, and 9.6% on Xbox). And it still regularly brings in 280K to 400K players every day: About 1% of BG3’s Steam player base has played for over 500 hours! That’s a little under 200K people. Astro Bot is also an evergreen seller, albeit a more niche, family one Astro Bot, 2024’s winner, has now sold 4.7M copies and generated $291M in revenue. The budget, including marketing, is almost certainly under $100M, given the small Japan-based core team and three-year dev timeline. You can really see why the tides are changing toward less expensive hubs. Astro Bot is the only first-party winner on this list, but follows other first-party winners of The Last of Us Part II (2020’s winner), God of War (2018), and Breath of the Wild (2017). Around 46.6% of Astro Bot’s copies sold have been physical, which is far higher than the typical game. This makes sense for a couple of reasons: There’s a large family audience for this one, and physical boxes are an item to wrap when giving Astro as a gift. Astro has collector value for the PlayStation core (this is nostalgia-fueled platformer celebrating PlayStation’s history) Want more free estimates and insights in your inbox twice a week? Subscribe below! Subscribe Astro is another one of those games that continues selling over time, regularly selling more than 100K a month. It’s sold around 1M more copies this year ($60M in revenue) and is a popular title with families. We can see this using the Alinea platform’s MAU crossover tool: Astro Bot’s top #2, #3, and #4 games by crossover in any given month this year are Minecraft, Fortnite, and Roblox – without fail. The #1 title every month, though, is Astro’s Playroom, a pack-in with all PS5 consoles. For every month this year, between 20% and 30% of Astro Bot players also played Astro’s Playroom that month. So the free pack-in is a noice funnel for converting players to a full paid product. Expedition 33 sells 8.7M despite Game Pass cannibalisation Finally, we have last year’s winner – Expedition 33. The turn-based-RPG banger has generated $366M via 8.7M copies sold, with 58.8% on Steam, 35.7% on PS5, and 5.5% on Xbox. Xbox’s share of copies sold is this low due to Expedition 33 launching on Game Pass, where 4.3M people across console and PC accessed the game. A little under 700K Xbox players used their subscription to play Expedition 33 this year. That said, the game’s 1.5-year Game Pass deal ended last week on October 16, and we’re already beginning to see a positive trend on Expedition 33’s copies sold via Xbox (but the jury’s still out!). There’s understandably a lot of French pride behind this one, as France is the game’s #3 market on both Steam and PlayStation. Vive la France! One thing that stood out to me is that the GOTY winners aren’t $300M Hollywood productions made in the US. They’re mostly mid-budget studios outside the traditional AAA cost centres. Lots to think about there. Also, good games sell well; who’d have thunk it!? And there’s a whole load of them this year, with GTA 6 still to come, too. GTA just made the cutoff point for the VGAs this year. What a coincidence! Loading... Cool links and other stuff Our physical games newsletter from Tuesday was picked up by GameSpot, Eurogamer, TweakTown, and a bunch of others. We’re offering a free trial of our platform for games companies. Send us a message here, or reply right here on Substack/email, and we’ll set you up. Next week, we’ve got some exciting news regarding the future of our newsletter, so stay tuned! The last word Reply to this email – or reach out here – if you have any feedback for the newsletter – or want to request a game for us to cover. Want to see why these companies (and many others) are subscribed to Alinea? Get a free platform trial! [Alinea Analytics boasts the most accurate PC and console estimates in the business. Game makers use our platform to understand their audience, keep an eye on the competition, monitor sales trends, and spot new opportunities. We equip game studios and financial institutions with accurate data and the confidence to make smarter, data-driven decisions. Want to talk about all things games market data? We’d love to chat!]

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Oct 22 • 1:02 PM EDT • Technology • alineaanalytics.substack.com
Report: Arizona men’s basketball roster spending trails top programs

Arizona men’s basketball’s budget for building a Final Four-caliber team is significant, but the UA is far from one of the top spenders in the sport, according to a new report on roster spending. Arizona will spend approximately $15-17.5 million on its men’s basketball roster, CBS Sports’ Matt Norlander and Isaac Trotter reported this week. […]

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Oct 22 • 1:00 PM EDT • Sports • sports.yahoo.com
Applications Open for County College of Morris Artificial Intelligence and Data Science Apprenticeship

MORRIS COUNTY — County College of Morris (CCM) is accepting applications through Monday, November 2, for the next cohort of its Artificial Intelligence (AI) and Data Science Apprenticeship, offering CCM students and adult learners living in New Jersey an opportunity to gain paid, hands-on experience while preparing for a career in the fast-growing fields of […]

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Oct 22 • 12:57 PM EDT • Science • parsippanyfocus.com
Democratic Virginia state Sen. Lucas accused of leading marijuana criminal conspiracy

U.S Attorney General Todd Blanche says a powerful Democratic Virginia state senator was charged with leading a criminal marijuana enterprise.

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Oct 22 • 12:54 PM EDT • Politics • abc7news.com
Democratic Virginia state Sen. Lucas accused of leading marijuana criminal conspiracy

U.S Attorney General Todd Blanche says a powerful Democratic Virginia state senator was charged with leading a criminal marijuana enterprise.

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Oct 22 • 12:54 PM EDT • Politics • 6abc.com
Summit County Public Health offering updated COVID-19 vaccines

Summit County Public Health has begun to offer the updated COVID-19 vaccine. Here's how to get it.

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Oct 22 • 12:24 PM EDT • Health • beaconjournal.com
HVAC issue ignites fire at business on Marketplace Drive in Hampton

HAMPTON, Va. (WAVY) – Crews in Hampton responded to a business fire Thursday morning. According to officials, firefighters were called to that fire, in the 100 block of Marketplace Drive, jus…

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Oct 22 • 12:20 PM EDT • Business • wavy.com
Pedal to the Metal: NASA’s Psyche Heads Toward Asteroid Belt

With a successful Mars gravity assist in its rearview mirror, NASA’s Psyche spacecraft has fired up its thrusters and is accelerating to the metal-rich

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Oct 22 • 12:16 PM EDT • Science • science.nasa.gov
NYC Health + Hospitals Encourages New Yorkers to Receive Their Annual Flu and Covid-19 Vaccinations during Respiratory Virus Season

NYC Health + Hospitals today announced that the 2026–2027 updated influenza and COVID-19 vaccines are now available for patients at its hospitals and

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Oct 22 • 12:09 PM EDT • Health • nychealthandhospitals.org
Former NC GOP Senate candidate sues Wake schools over access to public records

Wake says it would take 703 hours of staff time at a cost of $15,395 to process the public records request from Scott Lassiter.

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Oct 22 • 12:08 PM EDT • Politics • newsobserver.com
Question 3 would create all-party primary

Ballot Question 3 would eliminate political party primaries in Massachusetts and establish a single, all-party primary.

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Oct 22 • 12:07 PM EDT • Politics • westernmassnews.com
Ex-OpenAI science head launches startup with $215 million

-- Source link: https://tinyurl.com/44r9pmvj-- Note: Reuters has not verified this story and does not vouch for its accuracy

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Oct 22 • 11:38 AM EDT • Science • tradingview.com
UP Health System to leave Humana’s Medicare Advantage network in 2027

The coverage will end effective Jan. 1, 2027, and may impact some patients’ in-network access to UP Health System offerings.

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Oct 22 • 11:30 AM EDT • Health • uppermichiganssource.com
Slotkin's viral 'threat' to conservatives takes new twist as student moves to hold her accountable: 'Shocking'

Michael Bicksell, the University of Chicago student who broke the story, filed the ethics complaint arguing Elissa Slotkin's remarks targeted students.

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Oct 22 • 11:20 AM EDT • Politics • foxnews.com
Bellevue Counseling Program Ranked #1 in Nebraska

Bellevue University's Master of Science in Clinical Mental Health Counseling program earned the No. 1 ranking among Clinical Mental Health Counseling master's programs in Nebraska in the 2027 rankings published by MastersinCounseling.org. The ranking recognizes Bellevue University's online, CACREP-accredited graduate program for preparing studen...

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Oct 22 • 11:07 AM EDT • Health • news.bellevue.edu
Partnership opens nominations for 2027-28 DSM Fellowship Program

The Greater Des Moines Partnership is accepting employer nominations for its 2027-28 DSM Fellowship Program, a 15-month professional development initiative designed to help early-career professionals strengthen their leadership skills and build connections throughout the region. The program offers mentorship, networking, community engagement and professional development opportunities. Employers may nominate individuals with three to seven years…

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Oct 22 • 11:06 AM EDT • Business • businessrecord.com
Flutter Entertainment to Release Q3 2026 Update Nov. 4 and Host Call

Flutter Entertainment will release its third-quarter 2026 update on November 4 and host a webcast and conference call to review results.Key Highlights:Original SEC Filing: Flutter Entertainment plc [ FLUT ] - 8-K - Oct. 22, 2026This is an AI-powered summary. It may contain inaccuracies. Consider ve…

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Oct 22 • 11:03 AM EDT • Entertainment • tradingview.com
ACC Basketball: Top freshmen in the 2026 class

Who are the conference’s top freshmen?

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Oct 22 • 11:00 AM EDT • Sports • sports.yahoo.com
Federal prosecutors accuse Sen. Louise Lucas of using political power to benefit marijuana enterprise

Virginia state Sen. Louise Lucas was indicted Thursday on federal charges accusing her of leading a criminal marijuana enterprise and using her position as one of the state’s most powerful legislators to protect the operation and pursue financial benefits from Virginia’s emerging recreational marijuana industry.

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Oct 22 • 10:32 AM EDT • Politics • virginiascope.com
Opinion: In D.C. Schools, How the Science of Reading Offers a Blueprint for Math

Students in the nation’s capital posted gains in math and reading for the fourth straight year, according to the results of statewide accountability tests released last month. It was the latest piece ...

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Oct 22 • 10:30 AM EDT • Science • yahoo.com
Partnership is the key to small business success

Greater Rochester Chamber of Commerce highlights how partnerships accelerate small business success and regional economic growth through collaboration and innovation.

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Oct 22 • 10:00 AM EDT • Business • rbj.net
Tepper Sports & Entertainment Selects Marsh and Partners Risk Strategies as Insurance Brokers for Bank of America Stadium’s Multi-Year Transformation

The official website of the Carolina Panthers with access to tickets, schedules, news, videos, photos, statistics and more.

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Oct 22 • 9:56 AM EDT • Entertainment • panthers.com
Tepper Sports & Entertainment Selects Marsh and Partners Risk Strategies as Insurance Brokers for Bank of America Stadium’s Multi-Year Transformation

The official website of the Carolina Panthers with access to tickets, schedules, news, videos, photos, statistics and more.

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Oct 22 • 9:56 AM EDT • Sports • panthers.com
VSee Health Shareholder Letter

Projects a Transformative 2027HOUSTON, TX / ACCESS Newswire / October 22, 2026 / , Inc. (Nasdaq:VSEE) ("VSee" or the "Company"), a leading provider of telehealth and digital health solutions, today issued the following letter from Chairman and Chief Executive Officer Dr.

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Oct 22 • 9:30 AM EDT • Health • finance.yahoo.com
3 Titans players who could help replace DT Jordan Elliott

The Tennessee Titans released DT Jordan Elliott after a disturbing situation; we have 3 players who could replace him.

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Oct 22 • 9:30 AM EDT • Sports • sports.yahoo.com
CBS names J.J. Watt its No. 1 analyst beyond 2026
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Oct 22 • 9:26 AM EDT • Sports • sports.yahoo.com
YouTube says it’s not hiding the dislike button – this is what’s actually happening

Reports of YouTube moving the dislike button behind a menu have been showing up lately but, according to YouTube itself,...

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Oct 22 • 9:25 AM EDT • Technology • 9to5google.com