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The Ferrari 12Cilindri Manuale's Stick-Shift Might Not Be 'Real' But You've Gotta Stop Freaking Out About It
In essence, it was either going to be this "fake" manual, or no manual at all, and I personally believe in the lesser of two evils. Do you not?
Republican Sarasota Co. Commissioner Joe Neunder supported Hillary Clinton over Donald Trump
Sarasota Republicans are being asked to believe a former Hillary Clinton donor is now the MAGA choice.
Over two dozen sickened in growing cluster of Legionnaires' disease
Health officials believe the likely source is a cooling tower.
Olympic medalist George Stanich still believes in life-changing power of sports
For Stanich, sports became both refuge and runway
'iPhone Ultra' Likely to 'Repeat the iPhone X Story'
Apple will likely "repeat the iPhone X story" by unveiling its foldable iPhone at the same time as the iPhone 18 Pro and iPhone 18 Pro Max, but starting foldable iPhone pre-orders at a later date, according to analyst Ming-Chi Kuo. Kuo today said manufacturing challenges have limited early production of the foldable iPhone, which will reportedly be named iPhone Ultra. As a result, he believes the device may launch at some point after the iPhone 18 Pro models.
Americans of all ages are spending less time socializing
It's a fundamental shift in the way we live our lives that has implications for everything from what we believe to how long we live.
Broncos Country believes Dobbins will have most impact
Assuming he can stay on the field all season.
Majority of UK smokers wrongly believe vaping is as harmful as cigarettes, experts find
Analysis shows public understanding about vaping, which is far less harmful than smoking, has plummeted in past decade
The twisted history Trump’s White House is using to redefine religious freedom
Is religious freedom on the retreat in America? A Trump commission certainly believes that to be true.
Everything You Need to Know for Brazil vs. Norway
Everything You Need to Know: Brazil vs. Norway — World Cup Round of 16 Brazil enters Sunday’s FIFA World Cup Round of 16 showdown as one of the tournament favorites, but Norway believes it has the firepower to produce one of the biggest upsets of the knockout stage. Five-time world champion Brazil meets Norway at…
Virginia Tech football: CBS predicts every Hokies’ game for 2026
How many games do you believe the Hokies will win in 2026?
For much of the past century, scientists believed dinosaurs were already in decline when the asteroid struck 66 million years ago — but a 2025 study published in Science found fossils in New Mexico showing they were flourishing in diverse, thriving ecosystems right up until the moment of impact
For much of the past century, many scientists believed the dinosaurs were already in decline when the asteroid struck 66 million years ago, a group past its prime that a cosmic accident merely finished off. A 2025 study published in the journal Science, built on fossils from New Mexico, argues almost the opposite. Right up […]
Jordan Spieth Warns Sports Betting Could Harm Golf Fan Behavior at Tournaments
Jordan Spieth believes the growth of sports betting is changing fan behavior at golf tournaments and says the issue may soon need to be addressed.
Jimmy Butler believes he’ll return better than ever
Jimmy Butler is confident his comeback from ACL surgery will be a successful one. The Warriors star says he expects to return as one of the NBA’s top players while revealing his desire to finish his Hall of Fame-caliber career in Golden State.
Scientists thought ravens followed wolves for food. A 2.5-year GPS study told a different story.
For decades, biologists believed ravens found their next meal by shadowing wolves across the landscape until the predators made a kill. A new study in and around Yellowstone National Park suggests the birds are using a far more sophisticated strategy.
Millie Bobby Brown believes she was a closeted gay soldier killed with a sword in past life
Millie Bobby Brown thinks that she was a closeted gay soldier who was slain with a sword to the spine in a past life.
2026 NFL Odds: Josh Allen, Buffalo Best Bet To Win AFC East
Find out why Will Hill believes that Josh Allen and the Buffalo Bills will win the AFC East next season.
'Big Short' Michael Burry may have own version of 'Buffett effect'
Michael Burry from "The Big Short" told BI he doesn't believe his stock picks move markets, but several commenters said a "Burry effect" might exist.
U.S. Officials Believed Israel Was Plotting to Kill Iranian Negotiators
Any Israeli attempt to kill Abbas Araghchi or Mohammad Ghalibaf would have derailed peace talks, American officials feared.
ESPN expert thinks 2026 could be the Houston Texans' year
Solak believes the Houston Texans already have the league's best defense and will return nine starters on that side of the ball
Ocasio-Cortez Endorses Abdul El-Sayed in Crucial Michigan Senate Race
The endorsement is the first in a contested Senate primary by Representative Alexandria Ocasio-Cortez this year, in a state that Democrats believe they must hold this fall to win a Senate majority.
They say Andy Burnham is ‘good at politics’ – but the proof will only come in time
The PM-in-waiting brings the promise of likability and a mission voters can believe in. He’ll need all that and more to survive, says Guardian columnist Zoe Williams
UFC champ Sean Strickland predicts unlikely future title matchup
UFC middleweight champion Sean Strickland believes a fight between him and a training partner at Xtreme Couture is inevitable.
Former Bucs edge rusher among notable free agents unsigned
Bleacher Report's Alex Kay believes former Buccaneers edge rusher Haason Reddick is still one of the top defensive free agents available.
Kendrick Perkins Thinks LeBron Is Truly Waiting For Cleveland
ESPN analyst Kendrick Perkins believes LeBron James wants to suit up for the Cleveland Cavaliers next season, but he's not going to guarantee a reunion at this time. James confirmed this week that he's not returning to the Los Angeles Lakers. His agent, Rich Paul, said he wants to have a chance at ...
Poll: Most Americans think the U.S. has strayed from its founding principles
Most Americans believe the country has moved away from its founding principles as the nation prepares for its big 250th anniversary, a new PBS News/NPR/Marist poll finds. Eighty-three percent of U.S. adults feel America has strayed from the ideals the country was founded on two-and-a-half centuries ago. Among them, close to half of Americans — 47% — say the U.S. has "moved far away" from these principles, joined by 36% who said America has “moved
LA sports radio host torches Lebron in blistering reaction: ‘Wasn’t a Laker’
The longtime broadcaster also suggested the split ultimately boiled down to money, saying he believes contract negotiations played a larger role than basketball considerations.
For crucial federal agencies, veneer of independence is stripped away
The ruling letting the president oust members of historically independent agencies without cause has shaken institutions that once believed their protections were secure.
LeBron On The Move
For the last few years, LeBron James’ name has popped up as someone who might be on the move in the NBA off-season. But few truly believed the future Hall of Famer would actually bolt from the Los Angeles Lakers. Now, it appears he actually won’t be playing for the Lakers in 2026-27. The source: ...
Did People In The Middle Ages Really Believe The Earth Was Flat?
Medieval people did not need Columbus to prove Earth was round — but later centuries needed that myth.
“Supergirl” is a decent standalone movie — so why is everyone acting like it’s awful?
Despite what the reviews and backlash may lead you to believe, the second film in the DC Universe is an enjoyable adventure.
7 things fantasy football players — and fans, too — should know about the Steelers’ offense
Believe it or not, Steelers training camp is only four weeks away. That means fantasy football season is right around the corner, too. One of the Post-Gazette’s...
Dale Jr. Fires Back At Criticism Of NASCAR Broadcast
Dale Earnhardt Jr. has been involved in the NASCAR media space for a while now, so the legendary driver is used to criticism. Over the weekend, some NASCAR fans expressed frustration with the TNT broadcast, as some believed that the analysts were underestimating the chances of Shane van Gisbergen ...
KFF Tracking Poll on Health Information and Trust: Update on Common Vaccine Myths
This poll looks at exposure to and belief in several vaccine myths and finds that people without a trusted health care provider, and those who regularly use social media or AI for health information, are generally more likely than others to belief the false claims. It also analyzes belief across vaccine myths, showing the share of the public that are consistent myth believers, consistent myth deniers, and those who land in the "mixed middle."
Poll: People Without a Trusted Health Care Provider Are More Likely to Endorse Vaccine Myths, As Are Those Who Often Use Social Media or AI for Health Information
People who don’t have a trusted health care provider are more likely than people with one to believe or lean toward believing several common myths about vaccines, a new KFF Tracking Poll on Health Information and Trust reveals.
Scientists may have finally found how Alzheimer's spreads through the brain
A common brain protein may be giving Alzheimer’s disease an unexpected way to spread, carrying toxic Tau proteins from damaged neurons into healthy ones. By blocking these harmful protein packages before they reach new cells, researchers believe it may one day be possible to slow the disease's relentless progression.
Netflix and Superheroes Are Having a Rough Stretch on Streaming....
(Welcome to my weekly streaming ratings report, the single best guide to what’s popular in streaming TV and what isn’t. I’m the Entertainment Strategy Guy, a former streaming executive who now analyzes business strategy in the entertainment industry. If you were forwarded this email, please subscribe to get these insights each week.) I have a quick prediction before we start today’s article: You might see this data in future news articles. Not my specific charts or analysis, but the core trend I’ve been monitoring—Netflix is having a lackluster Q2—will become inescapable. Often, folks want to know “What does the data say?” Well, that’s what it says. I haven’t seen this analysis hit the trades really yet, but I have a feeling some other outlets are going to start making this case soon. Remember, you read it here first. You probably have read about the problems facing superhero films at the box office this weekend. Well, this week, I explore whether superheroes are dying on TV as well! And the data says: definitely maybe! We have a lot to cover in today’s Streaming Ratings Report, which covers the two weeks of 18-May and 25-May. Today, I’m just looking at TV, like Netflix’s disappointing Q2, superhero shows underwhelming, a few TV shows dropping off the charts, The Pitt finally ending its epic run on the viewership charts (and whether “view counts” change its status as one of the biggest shows of all time), all the flops, bombs and misses, and a whole lot more. Tomorrow, I’ve got a great rundown of the film side of things. Let’s dive right in! (Reminder: The streaming ratings report focuses on the U.S. market and compiles data from Nielsen’s weekly top ten viewership ranks, Luminate’s Top Ten Data, Showlabs, TV Time trend data, Samba TV household viewership, company datecdotes, Netflix hours viewed data, Google Trends, and IMDb to determine the most popular content. While most data points are current, Nielsen’s data covers the weeks of May 18th to May 31st, 2026. You can find a link to my terminology here.) Subscribe Television - Netflix’s Q2 Slump Continues Having analyzed streaming ratings for going on half a decade, I have learned to trust my gut, but I’m always relieved when I can find actual data to back it up. For example, after a string of very popular shows like Stranger Things, Bridgerton, The Lincoln Lawyer and The Night Agent came out, week after week, in January and February, my gut wondered if Netflix had enough new and returning TV shows to sustain them throughout the year. Since then, Netflix’s post-March slate of shows has not impressed me. This week seemed to feature a potential new hit, but then, like a classic Duffer Bros. TV show, there was a twist. I speak of The Boroughs, Netflix’s latest (and last) Duffer Bros. produced show. The pitch is “Stranger Things with older actors”. And it topped the Nielsen charts: With just two weeks of viewership, The Boroughs would have been a top 25 debut show last year: But here’s the twist: Netflix has already cancelled The Boroughs! What happened? Likely a few things. First, the show didn’t do as well globally as it did in the US. As What’s on Netflix showed, it lagged behind several other shows that got cancelled. Second, its completion rate was likely low; after an initial burst of interest, it quickly dropped off on the Samba TV and Luminate charts. Third, the Duffer Bros. left Netflix for Paramount, and that may have factored into Netflix’s decision here. (Though I tend to believe that if a show is doing well, Netflix would have kept greenlighting seasons.) Still, just because I can explain why Netflix may have cancelled this show doesn’t mean I’m justifying it. In particular, as I’ve noted before, Netflix is losing a lot of their bigger shows as they reach their natural ends, and they need to replace those shows. This show had the hallmarks of a big new genre show, and it’s their biggest hit of the last few months (in the US at least), but now it’s done. Netflix’s other show this week—The Four Seasons, the second season of the “hit” show from last year—definitely disappointed. Its sophomore season had about half the viewership of the first, only 12.7 million hours. It also only had a two week run on Samba TV, and its numbers were all down on Luminate too. In other words, even with two successes, the Q2 slump for Netflix looks real: I could add to the list of disappointments: Both Lord of the Files and Man on Fire had short runs on the Nielsen charts. Running Point’s sophomore season also opened to about half its viewership, similar to The Four Seasons. A Good Girl’s Guide to Murder’s second season—see below—didn’t even make any of the three viewership charts I track, unlike the first season. Netflix is absolutely having a dismal second three months of 2026. If this Nielsen data is any indication, and I think it is, I think this will show up in Netflix’s engagement report, and maybe even their financial outcomes. And the rest of June doesn’t look much better. We have two hit shows coming back—Sweet Magnolias, one of their quietest big shows, and Avatar: The Last Airbender, a big hit for them in 2024—but the other big swings are limited series crime thrillers i.e. no future season potential. Like I said above, sometimes when I uncover a juicy nugget like this, other outlets end up writing very similar articles mimicking the data without credit. We’ll see if that happens this time! Share Television - The State of Superhero Shows on Streaming When I first heard the pitch for Spider-Noir—a Sony TV show on Prime Video that binge-released eight episodes first on MGM+ then on Prime Video two days later—I had my doubts. It’s a live-action Spider-Man show set in the 1930s, starring Nicholas Cage, based on a cameo of a character in Spider-Man: Into the Spider-Verse. No, seriously, that’s the pitch. That could either go terrifically well or horribly wrong. Great because, Spider-Man. He’s the biggest superhero we have. I’ve seen tracking numbers that put the new _Spider-Man: Brand New Da_y as the blockbuster of the year and initial pre-sales back that up. And yet this Spider-Noir pitch feels very esoteric. (Also, the eight-episode binge release feels very “Amazon copying Netflix” again.) So what’s the data say? And what does this say about the future of superhero shows?
Scientists Slam Trump Rule Change
Dr. Esen Sefik moved from Istanbul to New Haven 20 years ago because she believed the U.S. was the best place to do scientific research. Now, her advisees are wondering whether to stay in their home countries instead. Sefik described the U.S.'s changing research climate on Monday during a press conference about a proposed rule by the Trump administration that would require a political appointee to approve all discretionary federal grants.
ScottsMiracle-Gro names new CEO as longtime leader exits
The Marysville-based national lawn and garden manufacturer has announced some big leadership changes, effective immediately.
About 3 million people have dropped Obamacare health coverage after subsidies expire and costs rise
The Department of Health and Human Services suggests the 13% drop is due to a federal crackdown on fraudulent enrollmentut, but health analysts believe it's more likely related to the Jan. 1 expiration of federal subsidies.
Serbia's Vucic eyes new political chapter as he steps down from presidency
When Aleksandar Vucic announced that he will step down as president of Serbia, cutting short his mandate and likely triggering early elections, few believed that he would disappear from politics.
Viewpoint: The dangerous influence of ‘woke’ post-modernism in science
rom an article in Science magazine by journalist Rachael Zamzow, we learn that many social scientists believe that a published paper should
Ahead of the MLB trade deadline, here’s where the Yankees stand
Yankees general manager Brian Cashman is almost always aggressive when he believes in his team.
West Hartford Business Buzz: June 29, 2026 - We-Ha
A round-up of openings, closings, and other news about West Hartford businesses. Business Buzz is sponsored by NBT Bank, and we are very thankful for their support! By Ronni Newton I can't believe it's already June 29. It seems like it was just Memorial Day, and now suddenly we are finalizing
Nebraska Democrats warn of new political party for spoiler candidates
Two top leaders with the Nebraska Democratic Party are warning of a new political party they believe aims to put spoiler candidates in Nebraska’s big midterm races.
Mamdani Says Primaries Show Voters Want a New Kind of Politics
New York City Mayor Zohran Mamdani said he believes Tuesday’s state primaries, where the slate of progressive candidates won, show that American voters are looking for a “new kind of politics.”
Brain activity under anesthesia challenges what we know about consciousness
The unconscious brain appears to be far more capable than scientists once believed. Researchers found that patients under general anesthesia could still process language at a sophisticated level, distinguishing nouns, verbs, and adjectives while listening to stories. Even more remarkably, neural activity showed signs of predicting upcoming words before they were heard. The results challenge traditional ideas about consciousness and hint at new possibilities for brain-computer interfaces.
Porsche Cayman GT4 Race Car Replaced By New 911 GT4 Race Car Based On The 911 GT3, Which Won't Be Confusing
Porsche racing aficionados will note that, believe it or not, this is the first time Porsche has built a GT4 car out of the 911.
49ers News: Gotta let the Bosa Brothers dream go…
Adam Schefter believes Joey Bosa has played his last down in the NFL“Bosa turns 31 in July. Last year was the first time he appeared in double-digit games since 2021. The 49ers would pursue an edge rusher if Nick or Mykel Williams are behind the 8-ball on their rehab. Some believe Mykel begins the season […]
Stenberg Excited To Join Sharks, Believes He’s NHL-Ready
Ivar Stenberg says he is ready to be in the NHL next season. After being drafted No. 2 overall by the San Jose Sharks, he becomes yet another another big-name, highly-skilled player in their under-23 group. “They have something really good going on, so super happy to join a special group,” Stenberg said. The 5-foot-11 […] The post Stenberg Excited To Join Sharks, Believes He’s NHL-Ready appeared first on San Jose Hockey Now.
Trump news at a glance: president tests out a new ‘red scare’ ahead of midterms
Republican strategists believe rise of Mamdani could present opportunity to tag Democrats with most extreme views of the left – key US politics stories from Friday 26 June
Paxton’s support for IVF highlights broader divide among GOP
Anti-abortion activists believe life begins at conception, so many oppose IVF because it often destroys some embryos.
New district leaders could take over Brooklyn Democratic Party
The current chair said she believes in "moving forward."
ESPN believes Detroit Lions have best weapons in NFL
ESPN’s Bill Barnwell believes the Detroit Lions have better offensive weapons than any other NFL team in 2026.
Neuroimaging utilization in emergency departments has increased year-over-year for a decade
Researchers believe their new data could be used to better inform staffing coverage in modern radiology departments.
Making Our Own Luck
We are cross-posting a piece that former NIH official Kris Willis wrote for Macroscience. Kris is now the President and Founder of the Woodley Park Institute, for which I’m a board member. Picking winners or hedging bets? Federal science agencies have long wrestled with the question of how to ensure their billions of dollars of grants and contracts result in maximum benefits for Americans. On the surface, it might seem that a goal-oriented, interventionist style of management would be the best policy: prioritize our most pressing problems and distribute funding accordingly.This top-down strategy creates a unique hazard, though: bad choices can send resources in the wrong direction, resulting in slow progress that impedes the delivery of tangible benefits to citizens. Moreover, if decision makers pursue an applied advance when the underlying scientific principles remain poorly understood, they risk costly failures and a loss of support for the research enterprise at large. Examples include Nixon’s 1971 War on Cancer, undertaken on the premise that a cure could be achieved in less than a decade, the drive to build an operational commercial fusion plant by the mid-1990s, and the National Plan to Address Alzheimer’s Disease, which failed to produce the effective treatments and prevention strategies promised by 2025. The contrasting laissez-faire approach is to hedge your bets. If the path to an advance is impossible to predict, then the wisest choice might be to distribute funding to as widely as possible. The main risk of this strategy is that spreading funding thinly may limit the resources available to the most promising research, resulting in the same negative outcomes as the interventionist approach: limited support for the most promising topics, slow progress, and delayed returns. In reality, at science agencies like the National Science Foundation and National Institutes of Health, program managers navigate between these two extremes, setting some funds aside to target high-priority areas and using the rest to cover the widest possible range of meritorious proposals. This middle path seems like the most rational way to proceed, but it still requires making choices. How much should be set aside for high priority topics? What should those topics be? How should we define merit? Expert opinion can provide a helpful guide, but leading experts can have remarkably different opinions about what matters and what should be prioritized. Moreover, experts and administrators alike can be risk averse, giving an edge to high-profile, well-established concepts. What’s really needed is a data-driven framework to help guide decision-making, one that doesn’t simply repackage prestige or incumbency. Recognizing breakthroughs years in advance Many breakthroughs fail to attract funding or recognition at the earliest stages of development. Katalin Karikó, for example, spent years struggling to win grants for work on mRNA that would eventually win her and Drew Weissman a Nobel Prize. Similar stories can be told about Jim Allison’s groundbreaking studies leading to the development of cancer immunotherapy, Stan Pruisner’s demonstration that prions can self-replicate without DNA, or Robin Warren and Barry Marshall’s proof that Helicobacter pylori, not stress, causes ulcers. Yet at some point, the scientific community recognizes and responds to transformative breakthroughs like these. How does that change happen? And what if science funders could identify the areas that are on the cusp of a breakthrough? Those questions led my collaborators and me to study how scientists responded to past breakthroughs. Based on patterns in that data, we developed a means of predicting future breakthroughs, using biomedicine as a proof of concept. It’s worth taking a moment to describe how our approach works. Briefly, our prediction process begins by grouping the 18 million or so peer-reviewed papers in PubMed, the authoritative database of biomedical research, into roughly 50,000 unique topics. A small subset of these topics are so widely acclaimed as breakthroughs that they have been recognized with a major prize like a Nobel or a Lasker Award. We theorized that studying the development of these outliers over time, especially before they gained acclaim, was the key to identifying future instances of them. After defining topics, we chose 21 representative breakthroughs and asked what they looked like before they won prestigious prizes. To answer that question, we re-ran our topic-mapping algorithm repeatedly, winding back the clock one year each time, stringing together the years to follow the progress of each field as it grew and advanced. We found that in each case, the years leading up to a discovery followed a pattern: a burst of papers on a new, rapidly evolving topic, many of which quickly became influential. These characteristics—the percent of papers that are new, the percentage of papers that are brought in from other topics, and the influence of each individual paper—can all be measured separately for any given topic. Together, they act as a predictive signal that is detectable an average of five years before a transformative discovery is made, and up to thirty years before the discovery receives a major prize. Scanning the current research landscape for topics that display this signal allows us to predict what work will likely produce a future breakthrough. Each year we analyzed includes four or five signals, a number that appears to have remained constant across a twenty year time frame. In their classic work on the sociology of science, Bruno Latour and Steve Woolgar established that the desire to participate in a major discovery is an important motivator for scientists as they consider whether they should take up (or abandon) a research problem. Although further work is needed, the simplest explanation for our results is that this behavior is widespread enough to detect at scale. A foundational advance, or something like it, draws the attention of scientists and causes them to change the direction of their research. They vote with their feet, staking their own reputation and careers by publishing on and citing the new idea. That upswell of interest is the foundation of our breakthrough signal. What kind of research does our model identify as a breakthrough? After building a model based on the patterns in our 21 preselected breakthroughs, we tested it by identifying all early signals of discovery from 1994 through 1997. Of the 18 signals we found in that time period, 17 can be traced forward in time to a breakthrough. Examples include super-resolution fluorescence microscopy (see the image above), the directed evolution of proteins and enzymes (Chemistry Nobel, 2018), and sequencing the human genome (National Medal of Science, 2008). The discovery of the role of leptin signaling in obesity is a particularly interesting case study. Around 1950, scientists noticed the existence of a type of lab mouse that suffered from a unique inherited form of obesity. When given the freedom to choose their own diet, these mice ate more than normal and preferred food that was high in fat. Researchers had few clues as to why the animals overate; early experiments pointed to the existence of a soluble ob factor found circulating in the bloodstream that regulated appetite, but its identity was unknown. In 1994, Jeffrey Friedman and colleagues identified and sequenced the ob gene, noting that the protein it encoded appeared to fit the profile of a circulating factor. A year later, a trio of high-profile publications demonstrated that ob was a hormone that regulated body weight and fat deposition by regulating appetite. One of these was co-authored by Friedman, who christened it leptin from the ancient Greek word for thin. Using our model, the data from 1996 make it clear this advance would become a breakthrough. Scientists had flocked to study the biology of the new hormone, generating the flurry of new papers and citations required to produce a signal. One of these demonstrated that serum leptin concentrations reflected the amount of adipose tissue in the human body, providing clinical validation of the earlier mouse studies. Before the identification of leptin, scientists were unable to point to a specific molecule that controlled appetite and adiposity, so that it was impossible to rule out non-physiological causes of obesity; its characterization fundamentally changed our concept of weight gain. In 2010, Friedman and fellow pioneer Douglas Coleman were awarded a Lasker for the discovery. Our work also identifies breakthroughs in clinical practice and behavioral and social sciences, even though these areas are less likely to draw the attention of major prize committees. One example that falls into this category is the introduction of endovascular aneurysm repair, a minimally invasive surgical procedure for the treatment of abdominal aortic aneurysm, a leading cause of death among Americans over the age of 65. Relative to the previous standard of care, it reduces in-hospital mortality by almost four-fold. In 2017, Timothy Chuter received the American College of Surgeons’ prestigious Jacobsen Innovation award for his multiple refinements to the technique. Another under-recognized breakthrough identified by our model is the development of standardized survey instruments to assess the quality of life for HIV+ patients. The antiretroviral cocktails introduced in the mid-1990s reduced AIDS mortality, but treatment came with serious side effects. The new evaluations showed that patients whose disease progressed had worse physical functioning than Americans with other chronic diseases, while those who were asymptomatic maintained a health-related quality of life on par with the overall US population. This evidence made it possible for patients and activists to argue that even in the absence of a total cure, and in spite of the side effects, alleviation of symptoms was a worthwhile priority for clinicians. My colleagues and I have failed to identify any significant recognition for the physicians and health policy experts who pioneered this advance, although in 2016, researchers called for the World Health Organization to set targets for good health-related quality of life as part of its framework to end the AIDS pandemic. From forecasting to funding How should science funders use our predictions? Any serious discussion of what we should do with this new capability needs to begin with an understanding of its limitations. We can’t (and shouldn’t) invest all of our resources in the small number of topics predicted to produce breakthroughs. Innovative new fields are born from existing ones; they rarely arise de novo. If funders don’t maintain a diverse portfolio, the breakthroughs of tomorrow will have no antecedents. Think of this as eating the seed corn, or killing the goose that lays the golden egg. There are also multiple goals of funding beyond basic scientific discovery, including translating discoveries into clinical practice, developing new technologies, supporting economic development, and training new scientists. The investments needed to accomplish these goals are likely different from those required to support emerging breakthroughs. Finally, we must be aware that we may not capture every instance of a breakthrough. The concept is fuzzy, and not every significant discovery is recognized with a major award. Further, breakthroughs are rare, meaning that our dataset is, by necessity, small. This makes formal estimates of accuracy challenging. Although our overall success rate appears to be high, any one signal may turn out to be a false positive. We found one apparent example: the development of the third generation COX-2 inhibitors, Vioxx and Celebrex, which were much celebrated in the early 2000s as effective but non-addictive pain relievers, meets all the algorithmic criteria of a breakthrough. Five years after it received FDA approval, researchers demonstrated that Vioxx was associated with serious cardiovascular complications, and the manufacturer voluntarily pulled the drug from the market. Celebrex remains available, although like other NSAIDs, it carries an FDA warning for increased cardiovascular risk. Decision makers who were overly focused on the breakthrough potential of this research might have wasted substantial resources nurturing an area that ultimately proved to be a failure—but so would those who relied on expert opinion at the time. That said, the potential benefits of funding the next mRNA vaccine or cancer immunotherapy years earlier than we might have are large. When we can’t assume the outcome of an action, it’s worth conducting an experiment. Can targeted support for areas that are poised to produce a breakthrough increase the return on scientific investment without cannibalizing future advances? With the necessary administrative infrastructure in place, conducting this experiment would be straightforward. First, identify all the breakthrough signals between 2018 and 2023, select half at random, and commit to a decade of investment. For biomedicine, a six year window should yield about 30 topics with the potential to produce a breakthrough. Providing strong support to half of these might be accomplished for $300 million a year. That’s roughly half of the recent annual budget of the NIH Common Fund or around 20% of the fiscal year 2025 budget for ARPA-H. After five years, then again at ten, compare to see which group — the one that was actively managed, or the control — produced more breakthroughs, and on what timescale. Although we used biomedicine as an example, the same experiment could just as well be run for physics, materials science, or any other discipline. Any attempt to undertake such an experiment should keep three points top of mind. First, we can predict the topic of future breakthroughs, but the people and vision for how to move the work forward are still important. In practice, this means success requires active program managers with the expertise to develop the science and the authority to do so, including by recruiting investigators. Second, we would be wise to learn from the failures of past attempts to fund transformative research. High among these are funding modestly repackaged work, confusing the genuinely novel with the merely unfamiliar, and relying too much on incumbent investigators. All of these risks can be mitigated by thoroughly and intelligently integrating high quality data into portfolio management. Finally, we need to have patience. Even with strong funding support, producing a breakthrough takes time. If supporting breakthroughs is the best way to nurture the birth of new fields, we also need to accurately describe and properly manage the other two stages, so that we invest wisely throughout the productive lifetime of ideas and divest once they reach the point of diminishing returns. We would benefit from more study of all of these phases, especially the transition from one to another. More research could answer questions like: When does a breakthrough become an established field? How do the availability of funding, the size and characteristics of the available workforce, and the accumulation of evidence that disagrees with prevailing models affect a field’s decline? Exactly how do old ideas give birth to new ones, and can we speed up the process? The more we understand about the dynamics of scientific progress, the better we can maximize the odds that our curiosity leads to results. I’d call that finding a way to make our own luck.
J.D. Vance is heir to a more radical politics than Trumpism
…if, of course, he believes what he’s saying
🇺🇸 Y! Sports AM: Why not U.S.?
The USMNT, who play their final group stage match tonight, have given fans reason to believe in their status as contenders.
Americans are struggling to pay for health care. Here's why.
Fewer than half of U.S. adults said they believed they could pay for health care, medical appointments and prescriptions,
Stubborn, arrogant, a genius: France’s De Gaulle epic shows up the tepidity of our politics
The man who led Free France during Nazi occupation was single-minded to the point of obstinacy. But he believed in his own power to make history, says Guardian Europe writer Alexander Hurst
Fox News Poll: Looking ahead to America's 250th anniversary
A Fox News survey finds 53% of voters are proud of America and 54% believe the best days are ahead as the nation nears its 250th anniversary.
Noah Hiles: These Pirates don’t deserve to be buyers at the MLB trade deadline
I’ve long believed the MLB standings aren’t worth viewing until Memorial Day. With the regular season being such an extended grind, the first...
Venetian exec talks luxury meeting space and the future of conventions
Venetian Chief Sales Officer Tony Yousfi shares what drove renovations at the Convention and Expo Center and the innovations he believes will define the next era of conventions at the Strip resort.
Supreme Court rules against Rastafarian who sued prison officials for cutting his dreadlocks
The Supreme Court on Tuesday ruled that a devout Rastafarian who attempted to sue prison officials for cutting his dreadlocks could not proceed with his case, a decision that will likely make it harder for believers of other faiths to enforce federal religious protections in prison.
"The 'AI Stigma' is real and severely punishes developers": A new study shows how much using AI in games hurts sales, and the numbers are hard to believe
Amateur developers might be able to make a quick buck, but established studios are seeing serious declines when using AI during development.
Hospital must pay $23M jury verdict after radiologist misses spinal cord injury on CT
Plaintiff attorneys believe this is the largest non-death-related malpractice payout in the history of Maine, with Brewer-based Northern Light Health system on the hook for the damages.
Justice Department charges two more in alleged plot to attack White House UFC event
Two more men have been charged in the alleged plot to attack the UFC White House fight earlier this month, providing new insight on how far in preparation the Justice Department believes the group came in carrying out the would-be attack.
How This Common Painkiller Is Stopping Cancer From Spreading, Scientists Reveal - Futura-Sciences
Guess Who? The Painkiller Hiding a Secret Weapon Riddle: it’s in countless family medicine cabinets. It’s the go-to when fever or pain strikes. For more than half a century, scientists have known about its anticancer properties. Some even believe it might lower the risk of metastases—those are the little troublemakers...
Pirates Pitching Coach Confident Team Will Improve On The Mound
Bill Murphy believes Pittsburgh has been throwing the ball well.
1 in 3 Americans use chatbots for health advice. These 6 patients explain why.
They say cost, speed and other considerations drove them to AI. They are also learning what to believe and what to take with caution.
Gannon-Doak role 'main topic' for Scotland
Scott Allan believes Ben Gannon-Doak's role in Scotland's final World Cup Group C fixture with Brazil is "the main topic" in how the Scots prepare. The winger started the win against Haiti, playing a role in the winning goal, and came off the bench in the loss to Morocco. "I feel like when we land on the ball, we never really know what the next pass is," former Celtic and Hibernian midfielder Allan told the BBC's Scottish Football Podcast.
2026 World Cup | What should France expect from Iraq?
A year ago, when Graham Arnold was appointed, no one believed he could take Iraq to the World Cup. Morale was at an all-time low after losing 2-1 to Palestine, relinquishing a lead late on. The Lions ...
Poll: Americans draw a new line in the betting bonanza sweeping over Wall Street
A plurality of Americans believe betting on election outcomes should be illegal, The POLITICO Poll finds.
China imposes trade curbs on dozens of U.S. firms in retaliation for Pentagon blacklist
The Pentagon earlier this month updated its so-called 1260H list by adding a slew of Chinese technology companies to a roster of entities it believes have aided Beijing's military.
The Bucs unleashing Rueben Bain Jr. would help their defense
One analyst believes Tampa Bay's defense could benefit from allowing Rueben Bain Jr. to immediately play to his strengths.
CD Projekt Red co-CEO admits it "indefinitely" "lost the faith" of some fans after Cyberpunk 2077
The Witcher 4 developer CD Projekt Red believes it's yet to complete its "full redemption arc" after the disastrous 2020 launch of Cyberpunk 2077.
The Politics of Climate Possibility
Americans are far more likely to engage on climate change when they believe governments can deliver meaningful results.
Senate’s likely next No. 2 warns Trump if Democrats take the majority: ‘It’s going to be a fight’ on key values
Sen. Brian Schatz, who many believe will take over the second most powerful role in the Democratic caucus next year, has a warning for President Donald Trump: He could be dealing with a very different Washington if Democrats achieve the electoral gains they’re hoping for this fall.
Sean Payton says Broncos history is the franchise’s ‘lifeblood’
Sean Payton believes Broncos history and tradition remain the franchise’s lifeblood and part of building culture.
Fernando Mendoza getting more comfortable taking snaps under center
"It's a great offense. I really believe in coach Kubak's offense," Mendoza said.
UK business minister says he has no reason to think PM Starmer will resign on Monday
British business minister Peter Kyle said on Sunday he has no reason to believe that Prime Minister Keir Starmer is planning to announce his resignation on Monday.
UK business minister says he has no reason to think PM Starmer will resign on Monday
LONDON, June 21 (Reuters) - British business minister Peter Kyle said on Sunday he has no reason to believe that Prime Minister Keir Starmer is planning to announce his resignation on Monday.
UK Business Minister Says He Has No Reason to Think PM Starmer Will Resign on Monday
LONDON, June 21 (Reuters) - British business minister Peter Kyle said on Sunday he has no reason to believe that Prime Minister Keir Starmer is planning to announce his resignation on Monday. Speaking to Sky News, Kyle said he had a "frank" conversation with Starmer on Friday. Britain's ...
Bentley gives Mat Armstrong a shock with its verdict when he takes his rebuilt Continental GT in for a 'proper' service
Mat Armstrong took his rebuilt Continental GT to Bentley for a proper look over, and the verdict was so shocking, he couldn't believe it
Poll: Americans believe they aren’t being taught enough about democracy
A new NBC News poll shows that Americans remain committed to the nation’s founding ideals — but widely feel that schools are not adequately teaching what’s needed to sustain them.
'Proactive' Johansson's Motherwell appointment 'very exciting'
Former Hibernian player Kevin Nicol believes "proactive" Alfred Johansson's appointment as Motherwell manager is "very exciting". Nicol is assistant at Fredrikstad, who play in the same Norwegian top flight as Johansson's former club Rosenborg. Swede Johansson, 35, replaces Jens Berthel Askou, who became a hugely popular figure with the Fir Park faithful.
Singer Oliver Tree confirmed dead at 32 after helicopter crash in Brazil
The American musician is one of six people believed to have died after two helicopters collided over Rio de Janeiro.
Danhausen Is WWE's Perfect Sports Entertainment Character
Danhausen's meteoric rise as WWE's newest cash cow has been a phenomenon you would have to see to believe.
Charles, Pingree advance to Maine’s fall governor’s race
Charles, an attorney and president of a Washington D.C.-based lobbying firm, said he believes Maine is “ready for change.”
NIH Chief Defends His Management of the Agency
National Institutes of Health Director Jay Bhattacharya hit back Thursday at critics of funding cuts and other shifts at the agency, accusing them of resisting the kind of “fundamental change” he believes is necessary for modernizing the NIH and improving scientific research. Bhattacharya said that ...
In DRC, fighting Ebola means fighting misinformation
The Africa Centres for Disease Control and Prevention warns this strain of the Ebola virus may be the worst on record. There is no vaccine, and misinformation is rampant, as many people simply do not believe Ebola is real.
Why Top Professionals Are Ditching LinkedIn and AI to Return to This 1980s Business Habit
A new report reveals that 63 percent of executives believe missing out on this exclusive, offline invitation list is actively harming their careers. Here is the modern way to get a seat at the table.
Intel's stock levels mean investors believe its foundry business will succeed: Bernstein's Rasgon
Stacy Rasgon, Bernstein, and Dan Ives, Wedbush Securities, join 'Power Lunch' to discuss Intel's prospects of building chips in the U.S., Apple price increases and much more.
Landon Donovan Sounds Alarm on Youth Soccer Culture
Donovan believes an early emphasis on winning has harmed youth soccer.
Republicans actually do have a healthcare plan, and it’s a good one
Republicans have an opportunity to tell a different story than the one Americans have believed about them.
Little Rock business owner warns others after alleged vendor event scam
A small business owner says she lost $305 after applying to what she now believes was a fake food truck festival advertised in an Arkansas Facebook group.
Katie Couric (@katiecouric)
3,068 likes, 268 comments - katiecouric on June 17, 2026: "Rahm Emanuel has been a major force in Democratic politics for decades—from congressman and White House chief of staff to mayor of Chicago and U.S. ambassador to Japan. As the 2026 midterms approach, he joined me on Next Question to discuss President Trump's second term, why Democrats "lost the plot," why he believes the U.S. should end taxpayer-funded military aid to Israel, and what it will take for the party to reconnect with voters and regain lost ground. 🎧 Watch the full interview on YouTube or listen wherever you get your podcasts.".
A surprising discovery reveals the kidney has a secret backup system
Scientists at Mayo Clinic have uncovered a surprising new way the kidneys conserve water, revealing a hidden backup system that works independently of the hormone long believed to control the process. The discovery emerged when researchers testing an old drug called probenecid expected it to worsen polycystic kidney disease (PKD) but found it actually slowed cyst growth instead.
Tonali to Tottenham 'would be a strange move'
"Losing Sandro Tonali would be a major blow," believes former Newcastle United defender Steve Howey. The 26-year-old is drawing plenty of rumours early on in the summer transfer window, with The Telegraph reporting that Arsenal, Manchester City and Tottenham are all interested in signing the £100m-rated midfielder. "I reckon Sandro Tonali would ideally fancy going back to AC Milan but there are Tottenham links there," Howey told BBC Radio Newcastle.