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Two lethal doses failed to kill Christa Pike. The science behind a botched US execution

January 1995, when her 19-year-old daughter, Colleen Slemmer, was tortured and murdered.

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Oct 6 • 10:26 AM EDT • Science • timesofindia.indiatimes.com
UAMS Receives Grant to Provide Telehealth Nutrition Services, Remote Monitoring in Clinics in Batesville, El Dorado

The University of Arkansas for Medical Sciences (UAMS) will integrate telehealth nutrition services and remote patient monitoring at two of its clinics to help patients better manage their diabetes and chronic health conditions.

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Oct 6 • 10:20 AM EDT • Health • news.uams.edu
Bears Break Record With 34 First Downs As Jets Stumble

The Jets ran 32 plays while the Bears got 34 first downs. See the shocking numbers behind Sunday's 23-12 loss and what it means for the season.

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Oct 6 • 10:19 AM EDT • Sports • sports.yahoo.com
Waterbury Police Department

Earlier today, a neighborhood assessment was completed alongside the Waterbury Health Department, Public Works, Waterbury Police Department’s Community Relations Division and the Mayor’s Office to...

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Oct 6 • 10:17 AM EDT • Health • facebook.com
Brazil: Lessons from a Disaster

By Antonio Martins (Outras Palavras) Defeats become deeper and more prolonged when we misunderstand what caused them, avoid correcting course, and embrace “solutions” that only compound our mistakes. Lula’s government and the Brazilian left suffered a disaster in Sunday’s election. Contrary to every poll, the president finished the first round 2.2 million votes behind Flávio Bolsonaro—and, more significantly, 3.4 million votes below his total four years ago, when the machinery of the state was working against him and in favor of his opponent. His vote share declined in 98 percent of Brazil’s municipalities. The PL, the main party of the far right, elected 121 deputies and 28 senators, becoming the largest caucus in both houses of Congress. The parties aligned with the Centrão—Brazil’s bloc of transactional center-right parties—were somewhat diminished, but will still hold roughly 250 seats in the Chamber of Deputies and 35 in the Senate. That will make it easier to assemble the majorities needed to amend the Constitution or impeach Supreme Federal Court justices. If elected, Flávio Bolsonaro could appoint four members of the Court, substantially altering its internal balance of power. What produced these results? How can the far right be prevented from consolidating them into a prolonged political hegemony? And what is the essential change of direction the left now needs? Explaining the Disaster Across the commercial media and the exuberant chaos of digital platforms, interpretations are multiplying. Some focus on specific episodes: Lula’s absence from the Globo debate, his very close relationship with Alexandre de Moraes, or his emphasis on issues supposedly remote from most people’s everyday concerns, such as rare earth minerals. Among the more systemic interpretations, three seem especially questionable. One argues that the principal defeat was not the left’s, since its congressional representation declined only slightly. The decisive movement captured at the ballot box, according to this view, was a shift within the right itself—from the more moderate and transactional forces of the Centrão toward the more ideological and radicalized forces of the PL and Novo. A second interpretation holds that the nature of electoral and political processes has changed. The material interests and aspirations of society, it argues, no longer play the central role they once did; they have given way to forms of subjective self-identification that the left has yet to understand. And a third concludes that, because of these two developments, we should expect a political winter: a prolonged period in which the far right and the broader right dominate Brazilian political life. There are important elements in all three interpretations. The problem lies in what they deny or leave out: Lula’s third government was a small-bore government. It offered the majorities that elected it neither a clearly better life nor reasons to believe again in politics and its power to transform society. These failures flowed from two fatal accommodations, which I will examine below. As a result, the government suffered a slow but steady erosion of support. And, as has happened in so many Western countries, it gave the far right the opportunity to present itself as anti-system and to benefit from popular frustration and distress. The interpretation that emphasizes the migration of votes from the center-right and traditional right toward the far right has been advanced, among others, by the courageous journalist Leonardo Sakamoto. In his UOL column on Monday, October 5, he highlights the miserable behavior of the traditional conservative parties. Over the past four years, they repeatedly joined forces with the “neo”-fascists, helping to “normalize” them—a criticism that could equally be directed at almost the entire corporate media. Believing they could use the far right as a stepping stone, they instead ended up partly devoured by it. This was especially true in the Senate, where the PL’s gain of 13 senators and Novo’s gain of two came at the expense of the PSD, which lost nine; the MDB, which lost two; the PSDB, which lost two; and the PP, which lost one. Sakamoto’s observation is accurate and necessary, but it leaves uncomfortable questions unanswered. Why did the erosion of the Centrão benefit the far right rather than, for example, producing growth for the left—as has happened so many times before, both in Brazil and elsewhere? The answer is not difficult. Throughout its four years in office, Lula’s third government was almost invariably associated with the Centrão. Here lies its first accommodation: accepting the limits imposed by conservative institutions; avoiding, as much as possible, any attempt to strain those limits through popular pressure; and believing only in the modest changes that could be squeezed through openings in Congress. The failure of the campaign to end the six-day workweek is emblematic. Lula could have electrified the presidential race by pairing it with a popular campaign for passage of the measure. Instead, he chose to place his hopes in the hands of Senate president Rodrigo Alcolumbre. He generated no mass mobilization, did not force his opponents onto an uncomfortable defensive, and won no victory. In September 2025, the government squandered the greatest of its many opportunities to shake up conservative power in Congress. Popular opposition to the so-called Shielding Amendment—which, if approved, would have restricted criminal proceedings against members of Congress—brought crowds into the streets, mobilized primarily by artists and social movements. This opened the possibility for a broader political education: a campaign that could begin exposing the limits and dysfunctions of Brazil’s political system while putting Bolsonaro’s movement on the defensive for its predictable support of political privilege. The amendment was defeated. But the executive branch then backed away from the fight. It remained associated with an institutional world widely seen as corrupt, elitist, and indifferent to ordinary people’s struggles. In doing so, it forfeited its credibility as a vehicle for the protest vote. On Sunday, it reaped the bitter fruits. Are We Doomed? Taking a different approach from Sakamoto, the philosopher Moysés Pinto Neto and other writers have drawn attention, in their first analyses of October 4, to the fragmentation of the public sphere produced by Big Tech platforms. Through their algorithms, these platforms present each person with a different view of social reality. As a consequence, it becomes much harder to identify common material problems and demands—for example, the fight for labor rights or for a properly funded public health system. Voters no longer embrace such demands, these authors argue, because they no longer see themselves as part of a collective. Instead, they tend to value the identities assigned to them by neoliberal subjectivity—the role of the entrepreneur, for example. On this interpretation, the left’s possible error lies in clinging to outdated illusions. Moysés’s warning is highly relevant and resonates with arguments such as Naomi Klein and Astra Taylor’s “Apocalyptic Fascism and the Billionaires’ Bet.” Unlike a century ago, the far right no longer promises a radiant future. It concentrates instead on resentment—especially that of young men. “They belong to a generation that fears it may never own a home, but compensates with the pleasure it gets from constantly provoking progressives online. Convinced their future has been stolen, they share memes romanticizing historical authoritarian regimes,” the authors write. But Moysés seems to confuse this danger with inevitability. He fails to see that the left’s answer cannot be adaptation. On the contrary, it must strengthen the possibility of politics as collective action. Nor does he recognize that precisely such a reversal is already becoming possible in some of the most promising mobilizations of the twenty-first century: the election, at the end of 2025, of the young Muslim Zohran Mamdani as mayor of New York, on a platform centered on the intensely material fight for an affordable city; the Left Party’s victory in Berlin two weeks ago, built around the demand to expropriate private real-estate corporations; and the very recent wave of demonstrations in Spain—including an occupation of Madrid’s Puerta del Sol—in which tens of thousands of young people mobilized by the Tenants’ Union have demanded limits on rents. By putting itself in the straitjacket of the “fiscal framework” in the first months of 2022, Lula’s third government adopted the second fatal accommodation of its term. Faced with conservative institutions and a country devastated by four years of Bolsonaro, increased public investment was the government’s remaining weapon for offering a more dignified life to the majority and forging an anti-conservative pact with them. The same state that disburses 1 trillion reais a year to enrich a small class of rentiers could instead spend money to extend the Family Health Strategy to every Brazilian, at a cost of 30 billion reais; provide full-day public schooling and childcare to all adolescents and children—and, especially, relief to their mothers; achieve universal sanitation while cleaning up polluted urban rivers; multiply metro systems; begin transforming the urban peripheries; and undertake many other urgently needed projects. In April 2023, an article in Outras Palavras warned that the fiscal framework could “shrink the Lula government and preserve the forces that condemn the country to inequality and regression.” A year later, another article showed that restraints on public spending were strangling policies vital to ordinary people and undermining the president’s popularity. In November 2024 came a reality check, in the form of the government’s humiliating defeat in the municipal elections. Even then, the fiscal lock was neither removed nor loosened. On the contrary: throughout the government’s four years, fiscal restraint remained central to its political narrative. The administration proudly proclaimed that it had “put the state’s accounts in order,” without grasping either how misleading that phrase was—given the payment of 1 trillion reais in interest—or how badly the message was hurting it politically. Lula finally woke up in September 2026. The increase in Bolsa Família benefits, after four years of being frozen; the announcement that anti-obesity drugs would be offered through Brazil’s public health system; and the ban on online betting showed that the state has the power to act decisively on behalf of the majority when those in government are willing to confront obstacles. The huge marches that closed the campaign in Fortaleza, Salvador, Rio de Janeiro, and São Paulo on the eve of October 4 showed how such initiatives can mobilize activists and the broader public. But it was too late—and too little to change the outcome of the first round. History has not ended The possibility of a turnaround in the three weeks leading up to November 25 cannot be ruled out. It will not be simple or easy. Lula must not only make up a deficit of 2.2 million votes; he must also offset the movement of voters who backed other right-wing candidates in the first round, most of whom are likely to move toward Flávio Bolsonaro. Pulling that off will require a broad, grassroots effort to win over voters, potentially reinforced by new initiatives from Lula. The coming hours and days will be decisive. If Bolsonaro’s movement also wins the presidency, the result will create a high-risk situation for Brazilian sovereignty and democracy. The enormous challenges posed by such an outcome would require the left to reexamine, in depth and with a genuine willingness to engage in self-criticism, its political projects—or its lack of them—and its practices. But would that mean we are condemned to the long winter of far-right hegemony that some analyses are beginning to forecast? It is far too early to say, suggests a recent text by Álvaro García Linera, the thinker who served as vice president of Bolivia under Evo Morales. His central hypothesis is that this political current will prove short-lived. At a moment when the entire world is once again talking about sovereignty and protecting national economies, the far right offers a stale, recolonizing neoliberalism. Its submission to the United States is as blatant and pathetic as Flávio and Eduardo Bolsonaro’s overtures to Donald Trump. Its project amounts to something like every man for himself: greater inequality, capitalism without limits, devastation, and supremacism. Will it work? In the United States, just two years into his second term, Trump himself is reaching record levels of unpopularity and may be on the verge of losing Republican control of both the House and Senate in November. Every new beginning is difficult. Whatever the outcome of the second round, the defeats of October 4 show how profoundly the Brazilian left will have to rethink and rebuild. But just as it would be foolish to underestimate the seriousness of its mistakes, it would be equally foolish to conclude that rebuilding a political project is no longer possible. History has not ended. The times are moving faster than ever. Originally published in Portuguese by Outras Palavras. English translation by Eric Blanc; I’ve added the subtitles. More We can’t stop the far right at home or abroad without a revitalized labor movement, which is yet another reason why you should become a sustaining supporter of the Emergency Workplace Organizing Committee (EWOC) — one of US labor’s pivotal bright spots. Relatedly, Jacobin published a short piece of mine reflecting on a decade of Bernie Sanders inspiring a whole new generation of young worker organizers.

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Oct 6 • 10:08 AM EDT • Politics • laborpolitics.com
Federal Employees Face 10.9% Increase in Health Premiums as Open Season Dates Announced

Federal employees will pay higher prices for health insurance in 2027. On average, federal employees enrolled in the Federal Employees Health Benefits Program (FEHB) will pay 10.9 percent more toward their premiums in 2027, marking the third straight year of double-digit increases in the employe

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Oct 6 • 10:04 AM EDT • Health • fedmanager.com
This Muskegon exhibit reveals the artistry and science behind observing nature up close

From detailed natural history illustrations to specimens drawn straight from the collection, the exhibit offers something for budding scientists, artists, and curious minds exploring how we document the world around us.

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Oct 6 • 9:55 AM EDT • Science • mlive.com
Marcello Hernández' 'Good Hang' with Amy Poehler is a delight

'SNL' fans, this one's for you.

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Oct 6 • 9:43 AM EDT • Entertainment • mashable.com
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TowneBank to acquire NC bank for $154M

Suffolk's TowneBank plans to acquire Mooresville, North Carolina-based blueharbor bank for $154 million in cash and stock.

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Oct 6 • 9:40 AM EDT • Business • virginiabusiness.com
Becker’s Hospital Review Names RWJBarnabas Health and Rutgers Cancer Institute to 2026 “100 Hospitals and Health Systems

RWJBarnabas Health, together with Rutgers Cancer Institute, the state's only National Cancer Institute-designated Comprehensive Cancer Center, has been named to Becker’s Hospital Review’s 100 Hospitals and Health Systems with Great Oncology Programs list for 2026, for the fourth consecutive year.

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Oct 6 • 9:36 AM EDT • Health • rwjbh.org
WHO: No further signs of infections at Russian plague lab

The World Health Organization (WHO) said Monday there were no further signs of infections at the Irkutsk Research Anti-Plague Institute of Siberia, following one researcher at the facility reported…

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Oct 6 • 9:31 AM EDT • Health • thehill.com
HOMETOWN HEALTH: Pediatricians warn raw milk can increase risk of life threatening infections

The AAP says the risk is even greater for young children and pregnant women.

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Oct 6 • 9:22 AM EDT • Health • wdbj7.com
Baltimore’s small business owners want the city to codify more protections

Zehbras CrossFit is the thriving, Black-owned, affordable, and accessible fitness space owner and CrossFit coach Jeanelle Spencer long wanted to bring to Baltimore’s Black Butterfly. On any given weekday afternoon, barbells slam onto rubber mats as Spencer’s neighbors in Waverly cycle through burpees, pull-ups, squats, and more in the small gym at 3302 Greenmount Avenue. […]

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Oct 6 • 8:50 AM EDT • Business • baltimorebeat.com
Jacksonville Young Republicans back Wyman Duggan for Mayor

The GOP infrastructure is uniting behind a well-known name.

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Oct 6 • 8:49 AM EDT • Politics • floridapolitics.com
McClean hits out at 'incomprehensible' Derry treatment

Derry City player James McClean hits out at his treatment by Derry City amid an ongoing contract dispute with the club.

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Oct 6 • 8:22 AM EDT • Sports • sports.yahoo.com
A new business lands in Downtown Pelham, a space focused on women

The City of Pelham welcomed a new business in Downtown, She So Fancy 1 Stop Shop Boutique.

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Oct 6 • 8:14 AM EDT • Business • walb.com
Sun Life research reveals the ripple effect behind small business success

As Canada's small businesses navigate a rapidly changing business environment, new research from Sun Life shows that success is about more than growing revenue. It's about building resilience. When owners feel confident in their ability to weather challenges and plan for the future, they're more likely to invest in their employees, strengthen their businesses and create lasting impact for the people who depend on them. The findings align closely with how Sun Life supports small business owners,

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Oct 6 • 8:00 AM EDT • Business • finance.yahoo.com
Dare County workshop seeks stronger links between behavioral health and justice systems

Dare County community stakeholders, local law enforcement, and members of the local court system will come together Thursday and Friday, Oct. 8-9, to develop integrated strategies to effectively identify and […]

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Oct 6 • 7:45 AM EDT • Health • islandfreepress.org
Wilton business damaged by Monday afternoon fire

The cause of the fire and extent of damage are still unknown at this time.

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Oct 6 • 7:20 AM EDT • Business • wabi.tv
Caitlin Clark sends emotional message after missing Fever exit interviews

Caitlin Clark wasn’t with the Fever for Saturday’s exit interviews, but there was a meaningful reason behind her absence.

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Oct 6 • 7:04 AM EDT • Sports • sports.yahoo.com
Exclusive: At Starbucks, the future is smaller

Starbucks is on a mission to recapture its roots as a place to sit down for a cup of coffee. But it doesn’t think it needs a big footprint to deliver on that promise.

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Oct 6 • 7:00 AM EDT • Business • cnn.com
Scanning offers players like Martin Odegaard an edge as football becomes faster and more intense

Sky Sports Nick Wright tried out virtual reality technology designed to train scanning to see how some players are improving their off-the-ball awareness; Martin Odegaard, Aurelien Tchouameni, Marc Guehi and Romeo Lavia are among those to have used it

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Oct 6 • 6:05 AM EDT • Sports • skysports.com
Today's biggest TV deal? $2,000 off a 100-inch Hisense TV (yes, really)

Prime Big Deal Days brings major savings on Hisense U7SG MiniLED TVs, with discounts ranging from $650 to $2,000 off. Shop every size from 55 inches to 100 inches.

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Oct 6 • 6:01 AM EDT • Technology • usatoday.com
Behind the epic rumble in 'The Outsiders' at the Hollywood Pantages

Carefully choreographed stagecraft is at the heart of the epic fight scene toward the end of 'The Outsiders' at the Hollywood Pantages Theatre.

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Oct 6 • 6:00 AM EDT • Entertainment • latimes.com
The ozone layer was supposed to be healing. So why is this year's Antarctic ozone hole so big?

The ozone hole above Antarctica is unusually large right now, and it might signal a shift in how the gap in Earth's protective layer behaves.

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Oct 6 • 6:00 AM EDT • Science • livescience.com
Dave McCormick dreams of strengthening science, but Trump is researchers’ worst nightmare

The Pennsylvania senator’s gentle advocacy for NIH funding has had little apparent impact on the president he wholeheartedly supports.

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Oct 6 • 5:50 AM EDT • Science • inquirer.com
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Zinedine Zidane hails ‘exceptional’ Michael Olise

France head coach Zinedine Zidane has described Bayern Munich’s Michael Olise as “exceptional” after his team’s 4-1 win over Belgium on Monday. Les Bleus came from behind to score four late go...

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Oct 6 • 5:10 AM EDT • Sports • sports.yahoo.com
Kenya confirms first Ebola case imported from Congo after patient dies in Nairobi

Kenya’s Health Ministry has confirmed the country’s first imported Ebola case from Congo.

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Oct 6 • 4:43 AM EDT • Health • clickondetroit.com
Red snapper season opens Friday; anglers can donate carcasses for science and prizes

MOREHEAD CITY, N.C. — Recreational anglers will have three days to harvest red snapper this weekend, and North Carolina fisheries officials are asking them to c

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Oct 6 • 3:07 AM EDT • Science • wcti12.com
Nobel Prize in Physics to Be Awarded in Stockholm

STOCKHOLM (AP) — The Nobel Prize in physics will be announced Tuesday by the Royal Swedish Academy of Sciences in Stockholm. Last year, three scientists won the Nobel Prize in physics for research on the strange behavior of subatomic particles called quantum tunneling that enabled the ...

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Oct 6 • 2:43 AM EDT • Science • usnews.com
As federal grant cuts hit social sciences, McInnis ‘worried’ about funds

Yale’s federal funding declined by 1.5 percent in the last fiscal year, with cuts affecting social science fields — which the Trump administration has targeted. Yale President Maurie McInnis said last month that the government had been slow to disburse awards.

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Oct 6 • 1:48 AM EDT • Science • yaledailynews.com
Liverpool behind in race for £100m Andoni Iraola favourite

Liverpool have started the season well, but they are still some way from competing on all fronts. Andoni Iraola has his side looking increasingly confident on the pitch, but problems with the midfield...

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Oct 6 • 1:35 AM EDT • Sports • sports.yahoo.com
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In Business: Bemidji Woolen Mills Keeping Local Production Alive

https://youtu.be/dwmn4Xteru4 As more clothing production moves overseas, one Bemidji manufacturer is still keeping much of its work local. Behind the racks and finished products at the Bemidji Woolen Mills, much of the work here still comes down to people cutting, stitching, and sewing. In an industry where production has often…

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Oct 6 • 12:00 AM EDT • Business • lptv.org
The Business Behind the Blooms

Natalie Noll ’26 is putting her economics degree to work as the founder of Nova Flora, using lessons in pricing, markets and operations to build her floral business.

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Oct 5 • 11:00 PM EDT • Business • poole.ncsu.edu
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Little Rock board votes to fund construction of city employees’ health clinic

The Little Rock Board of Directors on Monday agreed to pay for the construction of a health clinic for city employees.

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Oct 5 • 10:15 PM EDT • Health • arkansasonline.com
Downtown Cape Girardeau business owners credit increased police presence for a safer weekend

Downtown business owners say this past weekend was noticeably calmer after Cape Girardeau police increased their presence with more walking officers, police vehicles and patrolmen on the ground.

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Oct 5 • 8:57 PM EDT • Business • kfvs12.com
Will Dawkins on AJ Dybantsa, Ending Wizards' Deconstruction Phase

From scouting character to ending the teardown, Washington Wizards GM Will Dawkins details the vision behind drafting AJ Dybantsa and how the franchise is finally shifting toward competitive growth.

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Oct 5 • 8:54 PM EDT • Sports • sports.yahoo.com
Signs of the times: Kodo Arts to showcase antique Japanese signs

The upcoming Kodo Arts Warehouse Sale Oct. 10-18 will feature an unusual collection of Japanese 'Kanban' or traditional shop signs from the 1800's and 'Tairyo-bata' fishing boat flags flown to

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Oct 5 • 8:35 PM EDT • Entertainment • theunion.com
Padres’ Potential Game 4 Starter Comes Back from Paternity List

Walker Buehler has spent the season being one of the San Diego Padres' most valuable starting pitchers. That might not be immediately apparent from the overlying statistics, but the metrics under the surface show a different picture. San Diego will be all hands on deck after dropping both games to the Milwaukee Brewers at American …

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Oct 5 • 8:04 PM EDT • Sports • sports.yahoo.com
BTSC Monday Night Football thread: Falcons at Saints

Enjoy the last game of the NFL’s Week 4 here at Behind the Steel Curtain.

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Oct 5 • 8:00 PM EDT • Sports • sports.yahoo.com
Authorities ID body of man found behind Fairview business

Authorities identified the man found dead behind a Fairview, Oregon business as 49-year-old Kerry Cottrell. Investigators suspect a medical condition, with the medical examiner to confirm cause and manner of death.

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Oct 5 • 7:43 PM EDT • Business • katu.com
The science behind the Superdome’s roar during the Domecoming game

Superdome Decibels Debunked: How loud was the Dome when Steve Gleason blocked the punt?

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Oct 5 • 6:33 PM EDT • Science • wdsu.com
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The Harvard Crimson (@theharvardcrimson)

24 likes, 0 comments - theharvardcrimson on October 5, 2026: "Caroline B. Kennedy ’80 introduced the Institute of Politics’ 60th anniversary forum Thursday, marking her first known public appearance at the Institute since she resigned from its Senior Advisory Committee more than six years ago. Kennedy — the daughter of President John F. Kennedy ’40, to whom the IOP is dedicated – stepped down as the committee’s honorary chair in 2020 amid concerns over the IOP’s diminished independence, declining programming, and tensions with Harvard Kennedy School leadership. Full story linked in bio. 🖋: Jen L. Phan and Mirei S. Saneyoshi 📷: Grace E. Yoon".

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Oct 5 • 6:15 PM EDT • Politics • instagram.com
On Your Side: Better Business Bureau shares tips for winterizing your home and car

The Better Business Bureau has tips to help you winterize your home and vehicle so you’re prepared for anything the season throws at you.

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Oct 5 • 5:35 PM EDT • Business • ky3.com
Luis Silberwasser out at TNT Sports as CBS’s David Berson takes over Skydance’s combined sports group

The long-anticipated marriage of CBS Sports and TNT Sports now has a clear head of household, and it won’t be Luis Silberwasser. According to CNBC’s Alex Sherman, Silberwasser, chairman and CEO of TNT Sports, is exiting the soon-to-be combined Paramount Skydance and Warner Bros. Discovery, he told his staff in an email on Monday. CBS…

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Oct 5 • 5:35 PM EDT • Sports • sports.yahoo.com
SUV crashes into Winchester business

The vehicle accidentally went through the front door of Melanie’s Premium Outlet on Bypass Road, according to a social media post by the business.

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Oct 5 • 5:12 PM EDT • Business • wkyt.com
Tony Gilroy on leaving the politics of ‘Andor’ behind for his 9-composer music drama ‘Behemoth!’

Tony Gilroy’s “Behemoth!”.

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Oct 5 • 4:35 PM EDT • Politics • seattletimes.com
Tony Gilroy on leaving the politics of 'Andor' behind for his 9-composer music drama 'Behemoth!'

Tony Gilroy’s “Behemoth!” premiered over the weekend as the centerpiece of the New York Film Festival. Gilroy’s first film since the Star Wars series “Andor” concluded its acclaimed two-season run,

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Oct 5 • 4:34 PM EDT • Politics • oskaloosa.com
Tony Gilroy on leaving the politics of 'Andor' behind for his 9-composer music drama 'Behemoth!'

Tony Gilroy’s “Behemoth!” | WWL

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Oct 5 • 4:34 PM EDT • Entertainment • audacy.com
Tony Gilroy on leaving the politics of 'Andor' behind for his 9-composer music drama 'Behemoth!'

Tony Gilroy’s “Behemoth!” | KYW Newsradio

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Oct 5 • 4:34 PM EDT • Politics • audacy.com
Tony Gilroy on Leaving the Politics of 'Andor' Behind for His 9-Composer Music Drama 'Behemoth!'

NEW YORK (AP) — Long before Tony Gilroy wrote “The Bourne Identity," made “Michael Clayton” or created “Andor,” he wanted to be a musician. After playing guitar in a string of bands, Gilroy came to Los Angeles hoping to become a studio musician. A session with some real players quickly disabused him ...

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Oct 5 • 4:34 PM EDT • Politics • usnews.com
Fall Preview with Entertainment Correspondent Mike Marra

Airdate: October 5th, 2026 Leoni Township Update with Administrator Mike JesterOctober 5, 2026City Treasurer Hosting Town Hall Meeting SeriesOctober 5, 2026Tecumseh Appleumpkin Festival This WeekendOctober 5, 2026Fall Preview with Entertainment Correspondent Mike MarraOctober 5, 2026Disney’s Frozen Premieres Thursday at The SaukOctober 5, 2026Alison McGlynn & Lilly Hayworth, The Annex Collective SalonOctober 5, 2026John Spink, Nite…

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Oct 5 • 4:28 PM EDT • Entertainment • jtv.tv
Set your alarm: Jupiter will disappear behind the crescent moon in a once-in-a-decade alignment tomorrow

Skywatchers in the U.S. and eastern Canada can see a rare lunar occultation of Jupiter early on Oct. 6. Here are the exact times to see the giant planet vanish and reappear.

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Oct 5 • 4:20 PM EDT • Science • livescience.com
NYC Health + Hospitals/Queens Hosts Community Health Fair as Centerpiece of Hispanic Heritage Month Celebrations

NYC Health + Hospitals/Queens hosted a comprehensive Community Health Fair on September 30, serving as the primary event in the hospital’s month-long

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Oct 5 • 4:15 PM EDT • Health • nychealthandhospitals.org
Your Brain Under Anesthesia Behaves Surprisingly Like a Worm's, Scientists Discover

A shared experience of oblivion.

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Oct 5 • 4:00 PM EDT • Science • sciencealert.com
Darko Rajakovic Reveals What’s Behind Kawhi Leonard’s Delayed Raptors Return

Toronto prioritizes long-term health over preseason minutes as the superstar ramps up his reconditioning process.

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Oct 5 • 3:44 PM EDT • Sports • sports.yahoo.com
Why I Don’t Think Ride Or Die Should Have Been Cancelled (And What Company Should Save It...)

(Welcome to my weekly streaming ratings report, the single best guide to what’s popular in streaming TV and what isn’t. I’m the Entertainment Strategy Guy, a former streaming executive who now analyzes business strategy in the entertainment industry. If you were forwarded this email, please subscribe to get these insights each week.) So…I recently came across a Reddit thread, talking about films on streaming, wondering why there are no reliable sources out there for streaming ratings data. Sigh. Honestly, as annoyed as I am that so many still don’t realize that we have streaming ratings, I somewhat get it. Until now, there was such a long delay between when a show or film came to streaming and when we got its viewership data; I understand why people were confused. (But, as you know, this just changed.) Also, even back in the day, how many people knew how well films did on television? Luckily, as a reader, you’re in the know. Okay, on to this week’s issue. I want to take a look at Prime Video cancelling Ride or Die and whether I agree with that decision. Overall, we didn’t have any breakout hits (no TV shows landed over 20 million hours according to Nielsen) but we have a lot of steady performers on the streaming charts. Plus, we’ll look at where $50 million in missing box office dollars went. (Spoiler: straight-to-streaming.) All that, plus new episodes of The Secret Lives of Mormon Wives, Supergirl heads to streaming, a new YA show does well on Netflix, the viewership for the Daily Wire’s $50 million fantasy show, what TV show hit-maker can’t make streaming hits, CD sales, all the flops, bombs and misses, and a whole lot more. Let’s dive right in! (Reminder: The streaming ratings report focuses on the U.S. market and compiles data from Nielsen’s weekly top ten viewership ranks, Luminate’s Top Ten Data, JustWatch and Reelgood interest data, Samba TV household viewership, company datecdotes, Netflix hours viewed data, Google Trends, and IMDb to determine the most popular content. While most data points are current, Nielsen’s data covers the weeks of September 7th to September 13th, 2026. You can find a link to my terminology here.) Subscribe Television - Ride or Die Is a Hit…But It Got Cancelled? What The Data “Says” I hate the phrase “here’s what the data says”, even though sometimes I find myself using it. If data just told us everything, we data folks would be out of a job! Data is often messy, complicated and nuanced. When it comes to strategy, many of the best decisions can’t actually use “data”, since it’s vastly too complicated to model. Anyways, I’ve been singing the praises of Prime Video’s Ride Or Die this summer, a show that did very well for them. And yet…it got cancelled. Now, usually when a show gets cancelled, a bunch of websites say “a hit show got cancelled”... Here’s the thing, though: in this case, they’re right! The data “says” that this show was a hit. Specifically, out of 522 first seasons to make a week on the Nielsen charts since 2020, it’s the 75th biggest. On Amazon, Ride or Die is eighth out of 41 first seasons: That’s top 15th percentile all time, almost exactly, which is my definition of a “hit”! I mean, outside of Reacher, Amazon needed a hit this summer! (Admittedly, Off Campus did well for Amazon in the spring, but Ride or Die performed even better.) So what happened? Why did Amazon cancel one of their rare 2026 bright spots? Well, Deadline reported a reason—which I’ll get to—but I’d break it down into three relevant questions: What is a given streamer’s reasoning? Is that reasoning sound? Could the stated reason not be the real reason? According to Deadline, Amazon felt the show “over-indexed” in middle-aged women. (This was based on leaks from within Amazon.) The logic is this: Amazon already reaches this demographic because of unlimited two-day shipping bundled with Prime, so they don’t really need more shows like this. Now, it’s my job to ask if that’s a good reason, and I’ll be honest, in this case, I don’t think it is. Sure, this show may “over-index” in middle-aged women—I’ll just assume that’s the case here—but I think folks often oversell how important over-indexing actually is. When a show is a “hit”, it isn’t a bit bigger than its rivals; it’s usually multiples bigger. For example, Elle only made the charts for two weeks at 8.3 million hours each. So Ride or Die was 80% bigger in its first two weeks, and likely had a much stronger hold, with its terrific 13 million hours in week three. Ride or Die was nearly three times bigger than Sterling Point through three weeks too. And that means that _Elle, Sterling Point a_nd other Amazon YA shows need to not just over-index a little with younger women (assuming that’s who Amazon prefers over middle-aged women), but massively over-index. Otherwise, more people in that demo (and a bunch more besides) likely watched Ride or Die. (I’ll try to explore this concept more in a future article.) And don’t get me started on how Ride or Die did compared to a certain (very, very popular, possibly the world’s most popular) YouTuber’s reality show…which didn’t make the charts after its first week and likely cost much, much more than Ride or Die. All to say, Amazon-MGM Studios/Prime Video can tell reporters that this show didn’t reach the right audience, but that excuse feels weak to me. So this leads to the third question: could other reasons have come into play? Yes! Renewal or cancellation decisions rarely (I’m tempted to say “never”) boil down to one variable. At its simplest, it’s two things: budget versus viewership. But often factors like critical acclaim, ownership and, yes, personal opinion come into play. In this case, Amazon has a new executive running things, and this show isn’t owned by Amazon-MGM Studios (unlike Elle). And yes, it may not have indexed with the right target viewers, too. Likely all of those factors came into play.1 My guess is ownership ended up mattering most. Amazon doesn’t own Ride or Die. It’s actually produced by another major studio. Fortunately/allegedly, this show is being shopped around. I can think of one brand new CEO who should consider it for one of his two major streamers…especially if he wants to rebuild goodwill in Hollywood. His name is on this list of exec producers of Ride or Die… If David Ellison needs some goodwill—and he does—rescue this female-led show tomorrow and grab some good headlines for a day. The data justifies it. Quick Notes on TV We’re just getting started with this issue, but the rest is for paid subscribers of the Entertainment Strategy Guy, so if you’d like to find out… How The Secret Lives of Mormon Wives latest season did on Hulu, post-controversy... Whether Supergirl soared on HBO Max... Why the box office is losing money due to the streamers... The viewership for the Daily Wire’s $50 million fantasy show... Updates on The Gentlemen, Lanterns, Outer Banks, King of the Hill and more... What former hit-maker has three streaming flops in a row... Whether The Mandalorian and Grogu popped in week two... All the flops, bombs and misses... And a whole lot more... ...please subscribe! We can only keep doing this great work with your support. If you want an idea of just how much content you’d get in a full issue, check out this older issue. Coming Soon! Oh man, we’re almost caught up! We just have two more issues, then the streaming Ratings Report will be coming out just two weeks after a TV show premieres! Next issue, I’ll be looking at the first two weeks of the NFL Thursday night games on streaming, a huge new spinoff, Reacher’s Neagly on Prime Video, and the latest edition of Monster: The Lizzie Borden Story on Netflix, the return of Slow Horses on Apple and MobLand (quietly one of their biggest shows) on Paramount+, and Dancing with the Stars on both ABC and Disney+. Plus I’ll take a look at animation for adults in 2026. The week after, a ton of movies are coming to streaming: Toy Story 5 on Disney+, Backrooms on HBO Max, Jackass: Best and Last on Paramount+ and The Breadwinner on Netflix, plus a Unabomber film on Netflix and a romcom on Prime Video. Woody Harrelson and Matthew McConaughey have a show on Apple, along with a game show inspired by Willy Wonka that everyone seems to hate. Long term, some crazy (but hopefully crazy like a fox) IP news. FX ordered a new Sons of Anarchy show from Charlie Hunnam, but it’s not about the biker gang. No, it features the show’s cast playing themselves in a new “meta-thriller”. Huh. And a lot of the cast is coming back. Next, Ryan Gosling is producing a Flintstones movie about a “grown-up Bamm-Bamm Rubble”. Also, huh. This one is in “early development” so we’ll see what happens. Both projects are based on IP, but also seem to have crazy takes on the IP, which I like.

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Anxiety over fuel prices points to ‘looming EV comeback’ in U.S.

Just when it seemed American car buyers had left electric vehicles for dead, there are new signs of life in that corner of the auto market.

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Pre-Columbian Archaeology Meets Science Fiction in Max Lehman's Quirky Sculptures

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Oct 5 • 2:56 PM EDT • Science • thisiscolossal.com
Doyon Foundation Selects New Executive Director

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Oct 5 • 2:11 PM EDT • Business • akbizmag.com
How a controversial camera system is monitoring mental health patients

The Lampard Inquiry started back in September 2024 and I remember going to the first hearing in Chelmsford. Subscribe The bereaved families made placards of their loved ones, they stood outside in silence and then laid flowers to mark the moment. Now, two years on, in a process meant to last another two years, there’s been a development. Last week, we were told the chair, Baroness Lampard, pictured below, could be looking at making interim recommendations. Throughout the process, she has remarked that although this inquiry is looking at almost 2,000 people who were under the care of Essex mental health services from 2000-2023 when they died, the findings could have national implications for other trusts. ‘Records 24 hours a day in patient’s bedroom’ So why has this happened? One system that the inquiry is going to take a closer look at is a controversial monitoring system called Oxevision. It monitors some vital signs of patients remotely by using a camera placed in a room. It’s used by 40% of NHS mental health trusts. But campaigners, particularly the group Stop Oxevision, have asked for this technology to be removed from mental health wards as soon as possible. I spoke to a member, Hat Porter, today and they described to me what they thought this technology did and explained their concerns: “It records 24 hours a day and it’s located in a patient’s bedroom, which is obviously somewhere you’d usually expect to be a private place. “Our concerns are that the use of the technology has been has been kind of implemented as a substitute for proper in-person support, that it’s kind of over relied on and that there’s a lot of misunderstandings and that the presence of a camera, which has often been used without people’s consent, sometimes without even their knowledge, that that has a really big impact on privacy, dignity and human rights.” ‘Not sufficient’ I put it to them that the company behind Oxevision would dispute their claims about consent and in videos I’ve seen online from NHS trusts, they make it clear that the technology is complementary to trained staff and not a replacement. [ ](https://channel4news.substack.com/p/the-nottingham-inquiry-what-lessons) [ How the Nottingham inquiry shines a spotlight on other key mental health care failings ](https://channel4news.substack.com/p/the-nottingham-inquiry-what-lessons) Victoria Macdonald · Feb 12 [ Read full story ](https://channel4news.substack.com/p/the-nottingham-inquiry-what-lessons) A team of lawyers has been working on the inquiry and with bereaved family members who have concerns about this technology. I spoke to solicitor Priya Singh, from Hodge Jones & Allen, who made the point that questions usually asked by nurses would be missing from using devices like this. “It’s not sufficient to say, oh, the patient is moving around. Somebody must go in and say, are you okay? Are you distressed? Do you want help? Is there anything I can do? Share Channel 4 News “How are you spending your time? So I think a lot of our families cannot see the function of it when ultimately the patient should only really be observed when they’ve been prescribed to be observed, they can be observed more, but that more should really be happening face to face.” The Chair will hear evidence over the next two weeks and then a decision made after that, which could have national impact if she does decide this technology should be investigated or even removed. The Department of Health and Social Care said: “The Government is committed to ensuring that lessons are learned from the Lampard Inquiry to improve patient safety. “We are confident that the Inquiry will play an important role in identifying wider learnings for the health system following the tragic events in Essex and will contribute to improvements in patient safety.” We approached LIO Health, which runs Oxevision, for comment. Subscribe Share Channel 4 News Leave a comment

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Oct 5 • 2:03 PM EDT • Health • channel4news.substack.com
Layla Zaidane: The politicians who can fix America’s polarization problem will win

Political predictions are notoriously unreliable, but here is one I am willing to stand behind: the elected officials who figure out how to govern across difference will dominate the next decade of American politics. With dysfunction and paralysis having become the status quo in Washington, elected officials who work together

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Oct 5 • 2:00 PM EDT • Politics • triblive.com
NWA C-Suite: Aaron Shew

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Oct 5 • 12:30 PM EDT • Business • talkbusiness.net
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St. Louis Prehistoric Life Show brings free fossil fun to the Science Center

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Justin Bibb’s new Blue Cities/Red States coalition seeks the ‘radical center’

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Oct 5 • 12:16 PM EDT • Business • crainscleveland.com
RWJBarnabas Health President and CEO Mark E. Manigan Named 2026 NJBIZ Executive Excellence Honoree

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Oct 5 • 12:10 PM EDT • Health • rwjbh.org
Astronomers discover possible planet born from a dead star’s ashes

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Oct 5 • 11:58 AM EDT • Science • cnn.com
Behind the Seams | Wildwood

Go behind the scenes at LAIKA Studios for an up-close look at the extraordinary costumes of ‘Wildwood,’ the studio’s most intricately designed stop-motion film yet. Nearly 20 years after ‘Coraline,’ LAIKA’s artists and designers reveal how every tiny stitch, button and layer of fabric is handcrafted and engineered to help bring its puppets to life, combining costume design, fabrication and animation at an astonishing scale.

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Oct 5 • 11:28 AM EDT • Entertainment • instyle.com
You Might Need to Replace Your iPhone 18 Pro Max

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Oct 5 • 11:00 AM EDT • Technology • lifehacker.com
RWJBarnabas Health President and CEO Mark E. Manigan Named 2026 NJBIZ Executive Excellence Honoree

Mark E. Manigan, President and Chief Executive Officer of RWJBarnabas Health, the largest, most comprehensive academic health system in New Jersey, has been named a 2026 Executive Excellence honoree by NJBIZ, recognizing his leadership and impact on New Jersey’s health care landscape.

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World Mental Health Day Preview

Marina Kerlow, Licensed Marriage and Family Therapist, joined Fox 5 DC.

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Davids Fights Washington Healthcare Cuts with Plan to Lower Costs, Protect Kansas Hospitals

WASHINGTON, D.C. — Today, U.S. Representative Sharice Davids (KS-03) introduced a comprehensive package of healthcare legislation that directly counters Washington’s recent healthcare rollbacks, which are increasing monthly costs and closing rural hospitals. Davids’ efforts would protect Kansas families from rising medical costs, block new federal red tape, and keep local hospitals and health clinics open.

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Oct 5 • 10:14 AM EDT • Health • davids.house.gov
Naples Comprehensive Health Names Danny Hogan Chief Financial Officer

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Oct 5 • 9:47 AM EDT • Health • southfloridahospitalnews.com
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Watch live: RFK Jr., Trump officials unveil health care price transparency push

Health and Human Services Secretary Robert F. Kennedy Jr. and Centers for Medicare and Medicaid Services Administrator Dr. Mehmet Oz will announce new efforts Monday aimed at strengthening health c…

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The Science Behind Female-Specific Firefighting PPE

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Asia-Pacific survey to employers and business membership organizations on labour, trade and responsible business conduct

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Scientists uncover recurrent patterns within chaotic quantum behavior

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Oct 5 • 8:00 AM EDT • Science • phys.org
Talkiatry Earns Joint Commission Accreditation for Behavioral Health Care

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Business Ingenuity Gives Birth to Edgy, an AI Agent Educated in the Theory Behind Natural Synergy™ to Show Leaders Where Their Organizations Are Headed

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Oct 5 • 8:00 AM EDT • Business • finance.yahoo.com
Reclaiming 'Health Sovereignty': EU Gastein Forum Confronts A Fragmenting Global Order

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Oct 5 • 7:29 AM EDT • Health • healthpolicy-watch.news
Keller on what happens when all politics is actually national

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Oct 5 • 7:28 AM EDT • Politics • massterlist.com
Business confidence held in negative territory in September

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Best Buy’s Techtober Sale Is Live with Big Discounts on PS5, Switch 2, and Xbox Games—and Unlike Prime Day, Deals Aren't Locked Behind a Membership

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Obesity Startup Ilant Health Bets Its Revenue On Better Patient Outcomes

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Move over kimchi, natto is appearing in health food shops everywhere

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Hurricanes Beat Flyers 3-2 In Overtime With Gostisbehere Heroics

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Oct 5 • 7:05 AM EDT • Sports • sports.yahoo.com
The science behind targeted oral peptides

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Providence Opens New Rural Health Clinic in Polson

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Oct 5 • 7:00 AM EDT • Health • flatheadbeacon.com
Yale School of Medicine On the Science of Childhood Anxiety, Say, Anxiety Disorders Are the Most Common Mental Health Challenges In Youth

Credit: Matt Bradbury October 5, 2026 - By Isabella Backman - Anxiety disorders are the most common mental health challenges in youth. Left untreated, they can disrupt the lives of both children and their families. The good news is that with intervention, most children will overcome these conditions. Across Yale School of Medicine, scientists are working to understand anxiety at every level, from common anxious behaviors to molecular biomarkers in the brain. They are using their findings to develop and disseminate new evidence-based treatments for childhood anxiety. Today, the go-to treatment for childhood anxiety disorders is cognitive behavioral therapy (CBT). This is a form of psychotherapy that teaches children skills for confronting anxious thoughts and helps them practice managing situations that cause anxiety. While it is the gold-standard treatment backed by considerable scientific evidence, up to 50% of children will not see sufficient benefit from CBT alone. Wendy Silverman, PhD, Alfred A. Messer Professor in the Child Study Center, co-directs the Anxiety and Mood Disorders Program alongside Eli Lebowitz, PhD, associate professor in the Child Study Center. One of their main interests is learning how to improve outcomes beyond CBT. “We’re developing cutting-edge, research-based knowledge that can reduce the suffering that anxiety causes children and their families,” says Silverman. Changing parent behavior YSM experts are investigating how to improve CBT outcomes for children by involving the parents. Silverman’s research has uncovered two main components of parent intervention that improve childhood anxiety: not enabling children to completely avoid the things that make them anxious and taking steps to enhance their autonomy. Parents may unintentionally reinforce their child’s anxiety by allowing them to avoid what makes them anxious. They also may unintentionally limit the children’s sense of autonomy by being overly intrusive. “One of the things that we take pride in is that we’ve focused on trying to understand what parents need to do, and to test our ideas and see if changing the parents’ behaviors is enhancing the effects of CBT,” Silverman says. “Our findings thus far suggest that they do." As much as CBT can be helpful, it can also be challenging to get one’s child to do the necessary steps for CBT to work. This is one important reason why Lebowitz created a novel intervention program for parents named Supportive Parenting for Anxious Childhood Emotions (SPACE). Existing intervention programs often teach parents to act as therapists for their child, such as training them on how to practice breathing exercises. “It makes sense, but this doesn’t work very well in practice,” says Lebowitz. “And part of the reason, I think, is that it’s not easy to get your kid to do things, especially if they’re not excited about doing it.” SPACE is unique because it focuses entirely on parent involvement and changing parental behavior—children are not involved in the sessions. For example, parents learn how to use supportive messages that convey confidence that their child can tolerate and manage distress. “It might sound like a parent saying to a child, ‘I get that this is really hard for you, but I know that you can handle it,’” Lebowitz says. The program also works with parents to identify the ways in which they are accommodating anxious behaviors. “We’ll pick one thing that parents are doing that is an accommodation and help them make a detailed plan for how they’re going to change that,” Lebowitz explains. Treating Anxiety in Children and Adolescents Much of the existing research on SPACE has focused on parents of children under age 14. Ongoing studies are now exploring its use with parents of older teens. “Both anxiety and accommodation can interfere with normative developmental shifts during the teen years, including increased autonomy and individuation from parents,” says Rebecca Etkin, PhD, associate research scientist in the Child Study Center. “In this sense, SPACE may be particularly well-suited for anxious teens and their parents. We want to see whether it is effective during this distinct developmental window.” Unfortunately, many families in need of CBT face barriers, including limited availability of services and geographic constraints. One way to improve access is digital interventions. Silverman and her team are developing an evidence-based digitized intervention program for parents that they can access directly from their computer or smart phone. “The work we’re doing will be one of the very few parent interventions that is digitized and importantly tested for effectiveness,” she says. Creating interventions for anxiety-related challenges Silverman and Lebowitz recently received a generous gift to develop and test other interventions that help parents reduce other child anxiety-related behavioral and emotional difficulties, such as restrictive eating and unexplained somatic symptoms. One of these projects in particular focuses on understanding the risks of social media and its potential benefits, including offering a sense of connection. “A lot of research has focused on the idea that social media is harmful and the less of it the better,” says Lebowitz. “But we actually see is that this is not quite right—there are negatives, but there are also positives. So, we’re trying to get a little bit more nuanced of a picture.” The team is working with teens with social anxiety and their parents over an extended period to better understand their social media habits and how their anxiety levels affect engagement with different platforms. The teens will answer questions sent to an app on their phones about mood and social media usage in an effort to capture emotional responses as they unfold. “We hope to develop interventions that can help make the best of social media while protecting against the more problematic effects,” Lebowitz says. The brain’s role in anxiety Researchers are also testing therapies to address anxiety at the neurological and molecular levels. In collaboration with Dylan Gee, PhD, professor of psychology in Yale's Faculty of Arts and Sciences, and Hilary Blumberg, MD, John and Hope Furth Professor of Psychiatric Neuroscience at Yale School of Medicine, Lebowitz and Silverman are using brain imaging to identify changes in a child’s brain before and after parents enroll in SPACE. In one study, children viewed anxiety-inducing images while undergoing magnetic resonance imaging (MRI); the researchers conducted scans with and without the children’s parents nearby. Before SPACE, children’s brains were better able to activate the regulatory circuitry needed to turn off an anxious response when their parents were nearby. But after SPACE, children could activate this circuitry even without the parent around. “As parents work on gradually reducing some of their accommodations, you can see a child get better at regulating their own fear system in the brain,” Lebowitz says. “It’s remarkable.” Research into the molecular underpinnings of anxiety can also inform new childhood anxiety treatments. In a recent study, Lebowitz, Silverman, and Flora Vaccarino, MD, Harris Professor in the Child Study Center, discovered that a protein known as fibroblast growth factor 2 (FGF2) could be protective from the toxic effects of stress. FGF2 levels in children and their parents were linked to the children’s risk of developing anxiety and depression, the study showed. The findings could help explain why some children who are exposed to early life trauma such as poverty or abuse are more prone to developing mental health disorders. And FGF2 could be a target for treatment. “This is very novel because it starts to give a clue to what is the molecular chain that connects those lived experiences to the actual psychological outcomes,” Lebowitz says. New ways to study and treat childhood anxiety Michael Crowley, PhD, associate professor in the Child Study Center, collaborates with Silverman and Lebowitz to study the role that attention plays in development and maintenance of childhood anxiety. There is a large body of research that shows that anxious children, like anxious adults, are prone to focus on threatening stimuli such as angry faces compared with neutral faces. This has led to innovative interventions that involve attention retraining. The idea is that if experts train children to look away from threatening stimuli, it may reduce their anxiety—especially children with social anxiety who are most prone to attend to threats. The researchers have just completed a clinical trial for attention retraining with 10- to 14-year-olds with social anxiety disorders and are currently analyzing the findings. Besides this innovative attention retraining research, as Crowly notes, “I like to design tasks that are engaging to kids,” Crowley says. “My goal is to assess something without the kids knowing what we are assessing.” With this goal in mind, Crowley has created a virtual game, named Boom, to study threat processing in children with anxiety disorders. The game is similar to that of hot potato—the child and three digital players take turns virtually passing a ball to each other’s gloves. At some point, the ball turns into a bomb, and as the bomb lands in each player’s glove, the outline of the glove turns yellow. The goal is to avoid having the bomb go off in your glove. What isn’t obvious is that the game is designed to measure different types of threatening stimuli, both ambiguous and direct. In the game, the direct threat occurs as the bomb is traveling towards your glove. The ambiguous threat is the yellow outlined glove as it is unknown where the bomb will travel next. While children play the game, Crowley’s team measures their brain activity using electroencephalography (EEG). The researchers have discovered that in kids with anxiety, the brain reacts more strongly to ambiguous threats than it does in their peers, but less strongly to direct threats. They believe that the initial abnormally large brain response to not knowing where the bomb is going impairs the brain's ability to properly respond when the threat is actually traveling the child’s way. “The brains of children with anxiety are unable to differentiate between threats you need to do something about and those that are not your problem.” Michael Crowley, PhD, develops innovative games for studying anxiety in children and adolescents.Credit: Matt Bradbury Based on these insights, Crowley hopes to study whether interventions like attention training could restore appropriate threat processing. Crowley’s team is also working on a test called the Balloon Risk Avoidance Task, which evaluates risk-taking and avoidance behaviors. It features a digital balloon that is full of air and about to burst. Kids have six seconds to let air out of the balloon. The more air they let out, the less risk they face that the balloon will pop. But at the same time, the balloon becomes less valuable as it deflates. “The more air you keep in the balloon, the more points you get,” Crowley explains. So far, the researchers have found that when the balloons pop unexpectedly, teens with social anxiety show distinct brain responses. Studying these responses can help psychologists understand the underlying pathways driving the various manifestations of anxiety. The genetics of anxiety When Thomas Fernandez, MD, associate professor in the Child Study Center and of psychiatry, was still in training, there was a lot of excitement about understanding the genetics associated with autism spectrum disorder. Since then, scientists have identified around 250 genes associated with autism. The genetic contribution to anxiety disorders, on the other hand, has historically received less attention. Anxiety is less heritable than autism, but the genetic contribution for anxiety disorders that emerge in childhood may be higher than for anxiety disorders overall. While scientists estimate the heritability of anxiety disorders in general to be around 30% to 50%, some studies suggest higher heritability for certain childhood-onset anxiety presentations. “I saw firsthand how researchers in the field went about finding vulnerability genes for autism,” Fernandez says. “So, we’re using a very similar playbook for childhood anxiety.” “I saw firsthand how researchers in the field went about finding vulnerability genes for autism. So, we’re using a very similar playbook for childhood anxiety.” Thomas Fernandez, MD Associate Professor In the Child Study Center and in Psychiatry Now, Fernandez and Emily Olfson, MD, PhD, assistant professor in the Child Study Center, are studying children and their parents to identify genetic changes that are present in the child but not the parents, known as “de novo mutations.” “All of us have some de novo mutations—maybe about 50 to 100 sprinkled throughout the genome,” Olfson says. “But when they occur within the coding regions of genes, they can be really disruptive.” Previous research shows that people with autism have higher rates of damaging de novo mutations than the general population. In 2022, Olfson, Lebowitz, Silverman, and Fernandez published a study on 68 children and their families that found that children with anxiety had similarly high levels of these mutations. Studying de novo mutations can help point the researchers to where they should be looking for genes associated with anxiety. “The end game is using the genes to steer us toward the right part of biology that we can then target to come up with better treatments,” Fernandez says. Building on those findings, the team is now studying more families to better understand how these de novo mutations, along with other genetic and environmental factors, shape pediatric anxiety disorders. They recently received a National Institutes of Health grant to enroll 750 new families over the next five years. Olfson is the principal investigator, with co-investigators Lebowitz, Fernandez, Silverman, and Shuangge Steven Ma, PhD, department chair and professor of biostatistics at Yale School of Public Health. Neurodevelopment, Risk Genes, and Mental Health Conditions - The Olfson Lab Joel Gelernter, MD, Foundations Fund Professor of Psychiatry, is interested in how different anxiety disorders differ genomically. “We are studying social phobia, panic disorder, and generalized anxiety disorder, working to understand why people differ in their risk to these specific anxiety disorders and evaluating various risk factors,” he says. Gelernter was recently involved in one of the largest studies to date of the genomics underlying anxiety disorder. The study included around 122,000 people with anxiety disorders and around 730,000 without. It found that some genetic differences associated with anxiety were linked to signaling that helps reduce overactivity in the nervous system. Many anxiety medications available today work by targeting this process. “It’s nice when the biology that you get out of a large genome-wide study ratifies things that we already know because that can help increase confidence in further findings from the study,” Gelernter says. Uncovering the neurobiology of psychiatric disorders John Krystal, MD, Robert L. McNeil, Jr. Professor of Translational Research and chair of the Department of Psychiatry, is interested in the neurobiology of psychiatric disorders, including post-traumatic stress disorder (PTSD), of which anxiety is a major symptom. In the late 1980s, Krystal’s team discovered that the drug yohimbine activated symptoms in patients with PTSD. “This was the first time we could link a specific biological mechanism to the symptoms of PTSD,” Krystal says. At the time, he adds, this finding was highly controversial. “A lot of people felt that PTSD was a purely psychological syndrome that didn’t have an underlying biology.” Since then, Krystal has dived deep into understanding the neurobiology of PTSD to learn how to better treat it. His team is evaluating the use of ketamine and psychedelics. These would be among the first treatments to be developed specifically for PTSD. They may also be applicable for other disorders including anxiety disorders, Krystal adds. An important gap in PTSD treatment is the absence of biological tests that inform how to best help patients manage their PTSD symptoms. A doctor doesn’t diagnose cancer based on how they feel. Rather, they use tests of the biology of the cancer to determine the best course of treatment. “And we can’t do that in any psychiatric disorder other than Alzheimer’s disease,” Krystal says. “But now we are building a foundation for this approach to the treatment of anxiety disorders for the first time.” Source: Yale School of Medicine

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Oct 5 • 6:44 AM EDT • Science • goldrushcam.com
Three sheriff’s offices sign up for jail mental health hold reimbursements under new Wyoming law

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IRGC General Warns Regional States against Letting US Use Their Territory

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Oct 5 • 3:00 AM EDT • Science • yahoo.com
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