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Jay-Z picks himself to headline the Super Bowl halftime show at SoFi Stadium in Southern California
Jay-Z will be the featured performer for the halftime festivities on Feb. 14 at SoFi Stadium in Inglewood, California.
Commentary: Health care should serve people, not the companies that profit from denying or delaying it
Medicare for All will not pass tomorrow. That is no reason to stop working for it, or to turn down reforms that help people in the meantime, writes N.H. union president.
Intermountain Health breaks ground on Nevada’s first stand-alone children’s hospital
Intermountain breaks ground on Nevada's first stand-alone children's hospital
Intermountain Health breaks ground on Nevada’s first stand-alone children’s hospital
Intermountain breaks ground on Nevada's first stand-alone children's hospital
Intermountain Health breaks ground on Nevada’s first stand-alone children’s hospital
Intermountain breaks ground on Nevada's first stand-alone children's hospital
Intermountain Health breaks ground on Nevada’s first stand-alone children’s hospital
Intermountain breaks ground on Nevada's first stand-alone children's hospital
Fantasy football IDP free-agent report: Week 8
This is our weekly Waiver Wire feature depicting the best individual defensive players to target on waivers in fantasy.
Political ads are evolving as campaigns embrace AI and digital technology
With less than a week until Election Day in the 2026 midterm elections, political campaigns are ramping up their advertising efforts, using digital technology a
Intermountain Health Breaks Ground on Felicia and Ben Horowitz Children's Hospital
Intermountain Health broke ground on the new Felicia and Ben Horowitz Children's Hospital Monday, celebrating progress in the work to create Nevada's first stan
Celtics handle business at home, beat Bulls 134-99
Tatum and Pritchard shine in a big win at home.
Healthcare costs are on the rise in Minnesota, a top issue for voters. How much more could you pay?
Newport Beach residents, business owners busy preparing for potential record-setting high tides
Star Entertainment returns to positive earnings and cash flow in first quarter
Star Entertainment Group has returned to positive earnings and operating cash flow for the first time in more than two years, helped by stronger revenue across its casino and resort portfolio and lower corporate costs. Ahead of its annual general meeting in Sydney, the casino operator...
Cavs vs. Timberwolves game thread
The Timberwolves could be the best opponent the Cavs have faced this season.
Friend Development Group highlights new businesses, local revitalization
Friend Development Group, Inc., is seeing new businesses and economic growth in Friend, and there are a number of shopping opportunities downtown.
Trump administration attempting to prosecute former FBI Director James Comey again
The Trump administration is attempting to prosecute former FBI Director James Comey for what it calls disclosing classified information, employing the unusual maneuver of bypassing a grand jury. Comey’s lawyers
Former Padres Prospect Is Now A World Series Starter
The San Diego Padres got beat by a former prospect in the playoffs, and Robert Gasser is starting in the World Series.
Israel’s election could reshape its politics, without changing its course on Palestine
Israel’s election could reshape its politics, without changing its course on Palestine
Is the U.S. Bank Business Essentials Visa worth it for your small business?
The U.S. Bank Business Essentials Visa offers unlimited 2% cash back on eligible purchases — and up to 2.5% back with an eligible U.S. Bank business checking account.
Arkansas basketball frontcourt is obvious point of focus
If Arkansas has a question mark, it's clearly the frontcourt
As Trump brags about U.S. oil and gas company profits, his stocks gained millions during Iran war
A report from congressional Democrats found the president purchased millions in oil and gas stocks during the war.
Inside Business 2026 Top Forty Under 40: Charles Bruce Jr., Drucker + Falk
Charles Bruce Jr. is the assistant director of human resources at Drucker + Falk.
Divided nation: Republicans prize patriotism, Democrats equality-Poll
As crucial midterms loom, a Gallup/With Honor survey found no consensus that basic American values are shared across party and other lines.
Ennis Rakestraw Jr. unable to return after ankle injury
Detroit Lions cornerback Ennis Rakestraw Jr. left the Week 7 game due to an ankle injury, and he was unable to return.
Wizards rule out AJ Dybantsa for fourth-straight match
The NBA world will have to wait another night to see AJ Dybantsa's NBA debut.
Over 300 students learn science and technology at CCSD Family STEM Day
Over 300 students learned about science and technology industries at the Clark County School District Magnet Schools Family STEM Day on Saturday.STEM Day as he
Alaska Democratic Senate candidate Mary Peltola and her family suffer minor injuries in car crash
Peltola required medical attention after the accident, which happened when another vehicle crashed into the one transporting Peltola and her family, the campaign said.
Defender turns striker and scores in Bayern win
Bayern Munich beat Freiburg 3-1 away from home to reclaim top spot in the Bundesliga on Sunday (25).Dayot Upamecano was one of the standout performers, scoring the opener with a move in which he playe...
Scientists Discover How Excess RNA Can Disrupt the Energy Supply Inside Cells
Scientists at Texas A&M University discovered that excess RNA can interfere with the machinery cells use to produce energy, even without triggering certain immune defenses. The findings reveal an unex...
Health care shakes up the Iowa election
If Democrats flip Congress, health care could find its way to the top of their 2027 agenda.
Lycia Lands a $317M IPO for Inflammation Drugs Based on Nobel Prize-Winning Science
Lycia Therapeutics’ protein-degrading drugs are based on the research of Carolyn Bertozzi, a Stanford chemistry professor and Nobel laureate. Lycia’s lead drug candidate is in development for food allergy, where it could compete against the blockbuster Roche drug Xolair.
Bloomington business continues to blossom
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ESMO: Roche touts ‘convincing’ phase 3 KRAS data after win over rivals
Roche has shed more light on its investigational KRAS G12C inhibitor's phase 3 victory over Amgen’s Lumakras and Bristol Myers Squibb’s Krazati. The open-label Krascendo 1 trial enrolled 338 people with previously treated KRAS G12C-mutated non-small cell lung cancer (NSCLC). Patients who had already received a KRAS G12C inhibitor or pan-KRAS/RAS inhibitor were excluded from the trial. Participants received either divarasib once daily, Lumakras once daily or Krazati twice daily. Roche announced back in July that divarasib had demonstrated statistically significant improvements in progression-free survival (PFS) and overall survival (OS), meeting the trial’s primary and key secondary endpoints. But the Swiss pharma had been holding back the detailed data until now. At the European Society for Medical Oncology (ESMO) Congress in Madrid, Roche revealed that median OS for the 167 patients who received divarasib was 17.7 months, compared to 12 months for the 171 patients who received Lumakras or Krazati. The benefit was similarly clear when it came to median PFS, which stood at 9.8 months versus 5.7 months, respectively. A total of 44% of patients receiving divarasib were alive without disease progression at one year, compared to 24% of the control group, according to Roche’s presentation. It was a similar story for the objective response rate, which came in at 58% for divarasib versus 32% for the control group, while median duration of response was 11.9 months versus 6.9 months. Stefan Frings, M.D., Ph.D., deputy chief medical officer at Roche Pharma, told Fierce that the data made for a “very comprehensive, strong package, which should be convincing to health authorities.” “It’s an important advance for patients with lung cancer,” Frings said in an interview at a Madrid hotel during the conference. “It's a second-line setting, and patients who receive divarasib benefit compared to the current first-generation KRAS G12C inhibitors by having far longer overall survival,” he continued. “They live longer. They have better progression-free survival, better response rates, and with a safety profile which is—if [anything]—even better,” he said. According to Roche, 4.8% of patients receiving divarasib discontinued treatment due to treatment-related adverse events, compared to 11.7% in the control group. Serious treatment-related adverse events were also less common with divarasib, at 7.8% versus 15.2%. Roche’s confidence in divarasib had been building even before this phase 3 success. The candidate had already shown better potency and selectivity than the incumbent KRAS G12C inhibitors Krazati and Lumakras in preclinical tests. After cross-trial comparisons suggested that the edge translated into better clinical outcomes, Roche axed a study comparing divarasib to the chemotherapy docetaxel and went toe-to-toe with Lumakras and Krazati. “We designed the drug on purpose with higher potency and better selectivity,” Frings explained. “So, based on preclinical models, we clearly knew it would be superior to the first generation.” “It’s honestly not so frequent that pharma companies go head-to-head,” he added. “But if you want to make a point, if you want to convince payers, prescribers and patients … then a head-to-head win is rather rewarding.” While Amgen and BMS reached the regulatory finish line first for KRAS G12C-mutated, locally advanced or metastatic NSCLC in 2021 and 2022, respectively, they have struggled to capitalize on their head start. Krazati brought in $55 million for BMS in the second quarter, while Lumakras delivered $111 million to Amgen. For its part, Roche is aiming for peak divarasib sales of 1 billion to 2 billion Swiss francs ($1.2 billion to $2.5 billion), according to Frings. The Big Pharma is currently recruiting patients into a phase 3 trial comparing divarasib plus Keytruda against Keytruda plus chemotherapy in previously untreated advanced or metastatic nonsquamous KRAS G12C-mutated NSCLC. Roche has previously suggested that sales in metastatic disease would account for most of the forecast. Frings was tight-lipped on the exact timeline for a regulatory filing but said the Swiss pharma is “certainly keen to get this to as many patients as possible around the world.” Roche has more RAS drugs coming up behind divarasib. The pharma has already launched phase 1 trials of a pan-RAS inhibitor called RG6505 and a KRAS G12D inhibitor dubbed RG6620 in solid tumors. Roche’s partner Chugai Pharmaceutical is also testing a pan-KRAS inhibitor called AUBE00. Roche has made a “deliberate effort” to test a range of RAS drugs, Frings said. “If you have many rare mutations and you are scrambling to find sufficient patients, a pan-RAS inhibitor makes a lot of sense,” he explained.
Investment driving growth at NWS Crane
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Leafs’ Gavin McKenna Reveals True Thoughts On Connor McDavid
The Toronto Maple Leafs and Edmonton Oilers are facing one another in a Saturday evening showdown at Edmonton’s Rogers Place, marking the first time in the career of rookie forward Gavin McKenna that he’s facing Edmonton superstar captain Connor McDavid.McKenna, who has previously trained with McDavid over the summer, remains as much in awe of […] The post Leafs’ Gavin McKenna Reveals True Thoughts On Connor McDavid appeared first on HEAVY.
Inter Milan vs Fiorentina – Predicted lineup and team news
Inter Milan welcome Fiorentina to the San Siro on Sunday for their next Serie A game, aiming to climb to the summit of the table.The Nerazzurri arrive in outstanding domestic form, having avoided defe...
Is the WA ‘millionaires tax’ really coming for public pensions?
SEATTLE — When you think about the mansion- and yacht-owning millionaire crowd, retired schoolteachers don't typically leap to mind. Nevertheless, foes of Washington's new high-earner income tax are making a
Jesse Welles sang about politics and insects — and covered Black Sabbath and Bob Dylan
The rapidly rising "Join ICE" protest singer played solo and with a band on North Broad Street, and covered Bob Dylan, Black Sabbath, and Creedence Clearwater Revival.
Brian Thomas Jr. could be on the move
Jaguars WR Brian Thomas Jr. is believed to be a trade candidate leading up to deadline
Firefly Species Lost to Science for Over 40 Years Rediscovered In a Nature Preserve in Delaware
Entomologist and ecologist Christopher Heckscher made the discovery when he noticed the firefly’s specific flash pattern
Many people ignore nerve discomfort. A specialist explains why
A podiatrist explains why many people overlook nerve discomfort and what makes Neuro-Blast different from traditional nerve-support supplements.
What should become a Detroit Lions tradition at Ford Field?
What fourth quarter tradition would best fit the Detroit Lions?
Indiana vs. Michigan: How to watch today's NCAA college football game, where to stream and more
How to watch the Indiana vs. Michigan game this Saturday.
Ballon d’Or Preview: Odds, prediction, and how to watch
FC Bayern’s Harry Kane is poised to add a new trophy to his growing collection.
Ausar Thompson Suffers Injury During Pistons Win over Heat
Detroit Pistons forward Ausar Thompson left Friday's game against the Miami Heat with an apparent lower-body injury, adding to concerns after Jalen Duren's exit.
Oregon’s famous Carver Cafe, featured in 'Twilight' movie series, listed for sale
Carver Cafe, known for its appearance in “Twilight,” is for sale as its owner prepares to retire, but the business says it remains open.
Memorial Health System holds ceremony for final beam at new Sistersville General Hospital
SISTERSVILLE – Hospital officials, community members, state and local leaders, and representatives of Memorial Health System and the Memorial Health Foundation gathered at the construction site of the new Sistersville General Hospital on Friday for a signing and dedication ceremony of the final steel beam prior to it being raised into place. “We are still […]
EAST TEXAS POLITICS: State party chairs weigh in as first week of early voting wraps up
Texas Democratic Party Chair Kendall Scudder and Republican Party Chair D’rinda Randall join Blake Holland for this week's show.
Argentine-born Trump supporter credits president for Latin America's rightward political shift
Marcelo Sandrin, who has lived in the US for three decades, points to Argentina's Javier Milei and changing politics across South America as signs of Trump's growing influence.
NASA’s Swift Mission Ends, Leaves Behind Scientific Bonanza
NASA’s Neil Gehrels Swift Observatory has ended its science mission now that the spacecraft is orbiting less than 171 miles (275 kilometers) above Earth’s
Watch “The Simpsons”’ spooky stop-motion “Nightmare Before Christmas” parody from ‘Treehouse of Horror’ (exclusive)
The new opening comes from Stoopid Buddy Stoodios, the stop-motion team behind “Robot Chicken.”
Ken Block objects to Foulkes' 'October surprise' Costco announcement
Block said that while he too was excited for Costco, he accused board member Helena Foulkes of abusing her position.
Chiefs’ Rashee Rice, Jaylon Moore out for SNF vs. Seahawks
The Kansas City Chiefs will be heading to Seattle without two of their starters.
J.J. McCarthy Could Solve One Massive Problem for Giants
New York Giants quarterback J.J. McCarthy could solve a huge problem for the team.
World Series in Milwaukee impacts high school sports, Bucks home opener
High school football and the Milwaukee Bucks are making changes to accommodate the Brewers and sports fans.
Raiders entering a critical 2-game swing
Las Vegas has big opportunity in next 2 weeks
Before We Abolish Business Schools, Let's Look Beyond The West
Can the case for abolishing business schools travel? India’s experience suggests the answer depends on context, writes Vikas Kumar.
Giants' Cutthroat Najee Harris Move is Surprisingly Refreshing
The New York Giants' decision to cut Najee Harris this week was surprisingly refreshing.
Things to know when buying a business
Reverse due diligence isn't a typical business practice. But it should be.
T.J. Hockenson practices Thursday
Minnesota Vikings TE T.J. Hockenson a full go at Thursday's practice
Full practice for Jordan Addison
Minnesota Vikings WR Jordan Addison logs full practice on Thursday
Florida resident arrested after threatening US Rep. Jared Moskowitz
FORT LAUDERDALE, Fla. — A Boca Raton resident was arrested Thursday after making an alleged threat against U.S. Rep. Jared Moskowitz, the congressman announced. Just after 2:30 p.m., Moskowitz wrote
Is Raiders' Running Back Ashton Jeanty's Production Cause For Concern?
The Las Vegas Raiders have now dropped three straight, and concerns are growing about their star running back's production.
Clavicular pleads not guilty to raping a 17-year-old
'Looksmaxxing' influencer Braden Peters, a.k.a. Clavicular, has pleaded not guilty to charges that he raped a teenager at his family home.
Eagles to release E.J. Jenkins ahead of Cowboys matchup
The Eagles are releasing E.J. Jenkins, according to Mike Garafolo. The tight end appeared in all six games this season, making two starts
Peoples Could Become Rangers’ Future Setup Man for Latz
Armed with a 96-mph heater and elite contact suppression, Ben Peoples possesses the raw velocity and metrics to anchor a dominant late-inning bridge for the Texas Rangers.
Omaha Science Café Explores the Wild World of Spiders Oct. 27
UNL biologist Eileen Hebets, PhD, presents a talk on spiders at the Oct. 27 Omaha Science Café at the Rathskeller Bier Haus. Open to ages 21 and older.
Health insurance gaps leave families struggling with costs, survey finds
A new survey from GoodRx finds that even people who have health insurance are increasingly underinsured.
Health insurance gaps leave families struggling with costs, survey finds
A new survey from GoodRx finds that even people who have health insurance are increasingly underinsured.
CVS Health: Thank You! 101 Factory Farmer's Market & Cul2vate Employee Appreciation Day in Nashville, Tennessee
WOONSOCKET, RI / ACCESS Newswire / October 22, 2026 / Recently, colleagues from across and Aetna came together in Nashville to support the people and organizations making a meaningful difference in the community.The first stop was Cul2vate, a local nonprofit dedicated to addressing food insecurity by growing and distributing fresh, locally sourced produce.
MOVIE REVIEW: ‘Street Fighter’
The biggest problem with new video game adaptation “Street Fighter” is that it’s bad on purpose. Not “delightfully over the top” or “destined to become a cult classic.” Just bad.
Detroit Pistons: Javonte Green Breaks Down Clutch Shooting Vs. Celtics
The Detroit Pistons are starting the 2026-27 campaign with a 1-0 record after a huge comeback victory over the Boston Celtics on Opening Day
Community Health Center of the North Country, NAHEC to host event focusing on needs of older adults
POTSDAM — Community Health Center of the North Country and The Northern Area Health Education Center (NAHEC), through the Older Adult Rural Support (OARS) program, will host a community roundtable …
Trump rallying with Senate hopeful Ashley Hinson in Iowa as she pledges to push back on White House
SIA in-flight entertainment to get major upgrade, including larger screens, Bluetooth pairing
SINGAPORE – Travellers can expect a personal movie theatre experience on Singapore Airlines (SIA) routes after upgrades to its in-flight entertainment system, which will include touchscreens measuring...
Rashid Shaheed limited Wednesday
Seattle Seahawks WR Rashid Shaheed dealing with hip injury
Mexican Mafia member found dead in California state prison cell
Richard Buchanan, a reputed Mexican Mafia from the San Diego area, died in prison Tuesday morning, authorities said. Guards found Buchanan unresponsive in his cell at Kern Valley State Prison,
EDA approves final round of business development grants for 2026
The Grand Marais/Cook County Economic Development Authority Board met Tuesday, Oct. 20, approving five business development grants and the hiring of Redpath and Company to conduct a financial audit, among other agenda items. The meeting marked the third and final round of the EDA’s 2026 business development grants, which began the year with a $200,000...
Florida's Thomas Haugh Named Preseason AP All-American
Florida's senior forward enters the 2026-27 season as the backbone of the nation's top-ranked team.
$32M awarded through Mississippi Rural Health Transformation Program
JACKSON, Miss. (WJTV) – Gov. Tate Reeves (R-Miss.) announced 60 awards totaling $32,606,496.32 through the Mississippi Rural Health Transformation Program. He said the awards will help modern…
Film and TV shoots in L.A. continue to drop despite state tax credit
L.A. logged 4,171 on-location shoot days last quarter, down 4.8% from a year earlier, but tax-credit projects made up a growing share of TV and film work.
Former Chiefs lineman Allen Bailey reportedly dies at 37
Allen Bailey registered 22 sacks over his 10-year NFL career.
Former Chiefs lineman Allen Bailey dies at 37
Allen Bailey registered 22 sacks over his 10-year NFL career.
Travis Kelce recalls early morning phone call from brother Jason that Taylor Swift called ‘f---ed up’
Everyone knows midnights are her afternoons, Jason!
Trump’s Odd Interaction Sparks Fresh Health Concerns
The president is facing fresh concerns about his health after he made a peculiar move.
Pulpit Politics: Johnson Amendment Rarely Enforced
The Johnson Amendment prohibits tax-exempt religious and charitable organizations from endorsing or opposing political candidates. Some Oklahoma churches have found a loophole: partnerships with other organizations let them reveal political alignments.
Kroger pledges to cut grocery prices by $5B by 2029
Kroger shoppers could soon see lower prices at checkout as the grocery giant’s new CEO looks to cut costs.
WA hospitals face $6B threat, new report says
Hospitals in WA could lose nearly $6 billion by 2033 due to HR 1 cuts to Medicaid, according to a new report from Sen. Maria Cantwell’s office.
HOMETOWN ENTERTAINMENT: Smith Mountain Lake Center to stage Zombie Prom at Westlake Cinema
Zombie Prom takes the stage at Westlake Cinema starting this week.
Spurs, Victor Wembanyama Searching For Answers After Loss to Thunder
The San Antonio Spurs lost their first game of the season to the Oklahoma City Thunder on Tuesday night.
Trump pushes to evict the press from the White House
While moving the media out of the White House may be a relatively small debate considering Trump’s broader attacks on journalists, it would be highly symbolic.
Ebola in Kenya: Is it under control as nine cases confirmed?
The US has advised its citizens to reconsider travelling to Kenya but the government tries to reassure people.