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Extracellular vesicles in health, aging and disease
Figure 1. Stress-induced EV release by normal, stressed, aging, and cancer cells and their associated molecular cargo. Each EV type carries molecular cargo depending on the stressor and cell of origin. Senescence increases SA-EV output enriched with chromosomal DNA fragments and EphA2, promoting proliferation in Ephril-A1-positive cells via ceramide-dependent biogenesis [51]. Oxidative stress elevates intracellular Ca2+ and ROS, triggering microvesicle shedding and exosomes carrying mtDNA, oxidized proteins, and stress chaperones [15]. Hypoxia enhances exosome release with HIF-1a-driven cargo such as miR-210 and VEGF to promote angiogenesis [52]. Ionizing radiation activates p54 and TSAP6, producing EVs carrying altered miRNAs and gH2AX that induce bystander DNA-damage responses [53]. Apoptosis generates large ApoEVs containing DNA, histones, organelles, and cytosolic proteins, affecting immunity and tissue remodeling [54]. Chemotherapy and ER stress remodel EV cargo, including P-gp and PD-L1, promoting drug resistance and immune evasion [55].
Vote Smart Empowers Human Judgment as AI Influences Politics
Elise Blum and Dr. Kyle Dell examine who selects the information behind AI-generated political answers and why citizens must retain the final judgmentDES MOINES, Iowa, Nov. 02, 2026 (GLOBE NEWSWIRE) -- As voters turn to artificial intelligence to research politics, Vote Smart board member and educator Elise Blum and Executive Director Dr. Kyle Dell are urging citizens to examine the sources, standards, and incentives behind the answers they receive. In their opinion essay, “Preserving Human Agen
AI-generated political ads spiked in 2026, but campaigns still prioritized other means of messaging
For two election cycles, misinformation and election experts have wondered: Will content generated with artificial intelligence dominate races and mislead voters?
Turkey and one of its most reliable African allies are looking to generate $5 billion in bilateral trade
Turkey and Libya are looking to grow their bilateral trade to $5 billion, as both countries explore new ways to deepen their economic relationship
SC26: Aurora’s Expanded DAOS Storage System Targets Data Demands of Exascale Science and AI
Running simulations and AI workloads on one of the world’s most powerful supercomputers requires storage that can keep pace. On the ALCF’s Aurora exascale system, Distributed Asynchronous Object Store (DAOS) provides the high-performance storage needed to move and manage massive amounts of data generated by large-scale scientific applications.The ALCF recently completed a major expansion of […]
Mecklenburg battery energy storage project proposed
TerraForm Power proposes the Mitchell Energy Center, a 100-megawatt battery storage facility in Mecklenburg County to support grid demand and generate revenue.
Hundreds of Mundane AI Apps Are Hiding Sexually Abusive Deepfake Features
WIRED uncovered some 400 apps and websites linked to Chinese-language developers that look like regular AI tools but had secret features that let users create violent AI-generated images and video.
A 24-hour fast triggers a surprising repair response in the gut
Scientists have discovered that fasting for just 24 hours increases a beneficial gut bacterium that helps the intestines regenerate after radiation damage. The preclinical findings could pave the way for new treatments that protect healthy tissue during cancer therapy, potentially without requiring patients to fast.
Google Scores Big Win in Quest to Put Data Centers in Space
The prototype satellite for Project Suncatcher was able to beam back a short haiku about being in space, generated by Google’s Gemma 4 open-source AI model.
Attorney General Blanche on Rep. Garcia: ‘I would be very worried if I was a member of that committee’
AFGHS co-signatory countries ask health care users to help fill the financing gap
Hundreds of thousands of Ugandans living with HIV on antiretrovirals could be targeted for user fees or community health insurance schemes requiring modest premium payments, according to the April 2026 version of the country’s America First Global Health Strategy implementation narrative.1 As part of the “sustainable financing for the private not for profit sector” strategy, 491 facilities will be targeted for a phased introduction of user fees and scale up of community health insurance programs.2 In the Ugandan context, PNFP facilities include faith-based hospitals and other health facilities, US missionary organizations and centers of excellence—services that are often co-located at government facilities but run with additional financial and technical resources. 402,000 people—or about 28 percent of the total Ugandan adult PLHIV population on treatment—get ART from the private not for profit sector. The selected facilities provide the majority of ART and prevention of mother to child transmission (PMTCT) services. The plan doesn’t give the total number of clients served by the 491 facilities, so it is not possible to give a precise number. But the majority of 402,000 is a figure in the hundreds of thousands—hence the estimate I’m using.3 The April draft of the Ugandan implementation plan narrative is the only one I’ve been able to review. But the government of Uganda is not alone in turning to health care users to help fill the financing gaps caused by the abrupt withdrawal of US funds. In July 2025, the Government of Liberia introduced user fees for previously free services including “registration, accommodation, patient feeding, hospitalization, and a wide range of surgical and diagnostic procedures.”4 Earlier that year, Liberia rolled out a revolving drug fund designed to stabilize drug supplies by “allowing patients to pay a small fee for standardized, quality medications,” according to a Ministry of Health press release.5 (Both of these approaches had been proposed in the National Health Policy 2022-2031; media coverage explicitly connects the launch with the US foreign aid cuts.) The health financing strategies proposed by Uganda and established in Liberia are qualitatively different from user fees officially adopted by specific health facilities to cover funding shortfalls caused by the new US approach.6 The latter is a stopgap, adhoc change. The former is a national governmental adoption of policies that pass costs on to health care users, despite evidence that such approaches can exacerbate inequities and leave deficits unfilled. Two countries does not make a pattern, but they do point to urgent questions: Have other countries, including Liberia, included user fees or community health insurance schemes in their implementation plans? If so, do any of these narratives have what Uganda’s lacks: a fall-back plan in place in case these strategies for sustainable health systems fail to deliver—as they have before? I wonder if you think about it Subscribe Predictable pitfalls Both community-based health insurance and user fees are as old as the hills. And after decades of people climbing up these hills, duking it out, climbing back down—neither strategy has shown the results the Ugandan implementation plan is counting on. This is, in fact, a hill some folks are willing to die on. (You knew I’d get there, right?) In November 2025, an African-led team of health system experts published a paper directed at low- and middle income country governments trying to figure out how to create self-sustaining health systems. The money wasn’t coming back. It had been more than nine months since the season of freezing, waivering and wood-chippering; two months since AFGHS tumbled into the world touting co-financing requirements and reductions in future US government health aid. Governments were looking for strategies for sustainable, self-financed health systems, the authors wrote. For countries considering user fees and community health insurance to fill the financing gaps, they had a simple message: Don’t. On user fees, the paper states: “Reliance on user fees is ultimately a regressive and inequitable approach. It places a disproportionate burden on the poor and undermines health system goals of equity and financial protection. […] There is overwhelming evidence that user fees mobilise very limited resources for the public health sector, making it an inefficient mechanism for revenue mobilisation.” On community health insurance: “Attempting to shift the burden of funding previously donor-funded services, such as HIV care and management, and TB treatment, onto contributory schemes would exacerbate their fragility and fail to protect the population.”7 The WHO says that community-based health insurance “cannot be expected to provide a major source of funding or coverage,” and noted that most schemes offer only moderate benefit to individuals paying into them, and exclude the poorest segment of the population.8 And yet, the US-Ugandan implementation plan says that community health insurance is “the central pillar of this [PNFP] sustainability strategy” and that this approach that will generate “pre-paid pooled funding at facility and community level [that] improves financial risk protection for households, reduces catastrophic out-of-pocket expenditure, and generates structured, transparent revenue streams that can progressively absorb recurrent costs including health worker salaries.” Unfortunately, Uganda’s own history suggests the pillar might not be able to bear this weight. Ugandans Have Been to this Rodeo Before—and Some Want Their Money Back Uganda introduced its first community health insurance scheme in 1996 with support from international donors.9 Thirty years later, somewhere between 0.2 and 0.3 percent of the population is covered by CHI; just over 1 percent has any kind of health insurance.10 User fees were universally introduced in 1993 as a condition of a World Bank loan.11 They were abandoned in 2001, and in 2004—the year I moved to Uganda to watch the free HIV program get underway—a definitive study found that the fees did not improve health systems and outcomes.12 In 2004, most clinics and hospitals had ‘free’ and ‘fee for service’ options for getting care.13 The fee for service, or “cash and carry” programs had often been established in the years prior to PEPFAR and the Global Fund to Fight AIDS, Tuberculosis and Malaria. People who could afford to paid for the drugs, often at facilities in the private-not-for-profit (PNFP) sector. When free drugs arrived, some people who’d been paying kept on doing so, perhaps because of shorter wait times, greater confidentiality, convenience or other factors. But in the year that I spent visiting the same clinics around the country week after week—including a “center of excellence” that maintained separate days for cash and carry clients and those accessing free ARVs—lots of people who had been paying tried to switch to the free option. They’d paid because they had no other choice. They’d sold pieces of family land, begged family members for loans, bought pills by the week, and sometimes by the day. Or they were just cash-strapped, like most of us, and wanted the funds for other things. 14 Twenty-two years later, this hasn’t changed. Ugandans pay out of pocket for 30-40 percent of their health care costs, leading one paper to declare that “falling ill is more than a health crisis. It is a financial emergency.”15 One recent study found that up to 48.5 percent of households dealing with tuberculosis sold something, took out a loan or dug into savings to defray the costs of TB care—which is supposed to be universally free.16 The Ugandan implementation plan does anticipate challenges. It proposes a phased approach, with 187 facilities introducing user contribution systems in Year 1, 152 in Year 2, and 153 in Year 3. Willingness to pay and feasibility studies will precede roll out; fees will be tiered by region, and a waiver system is proposed to ensure that no one has to pay who is unable to. Moreover, the plan provides for quarterly reviews of epidemiological data to “ensure that user contributions do not compromise epidemic control gains, ART continuity for the client cohort, TB case management, or PMTCT services.” Alt text: A screenshot of a table included in the implementation plan narrative that is the subject of this stack. It’s got a fetching pink bar at the top. It uses the abbreviation “CHI” which is Community Health Insurance, and FBO which is Faith Based Organizations, and it details the number of facilities that will implement user fees with waivers and community health insurance schemes over the five years of the agreement. As I said in the footnote, this is a super interesting document with a lot of other rich material. Tell me what you see—and what you would have focused on. And if you’ve seen something like this, or anything else that strikes you, in another implementation plan, tell me that too. You can use the Substack message platform or try me on Signal at @endaplague_again.25 (because @mercoonfan was, weirdly, taken). But the plan doesn’t fully explain what will happen if this approach doesn’t work out. Yes, progress will be monitored, and corrective action triggered. However, there is no specified funding replacement if premium and fee revenue prove inadequate. Instead, the authors write, “Currently, COEs serve a total client cohort of over 180,000 across 28 facilities. In the initial years, the U.S. Government (USG) will provide financial support for clients; over time, user fees generated by COEs will become the primary source of funding for sustaining their services.” Failure does not really seem to be an option. Health insurance schemes are more acceptable to the Ugandan population than user fees. Members of Parliament and civil society traveled to Ethiopia to see how that country’s scheme worked. In a follow up report, a veteran civil society group recommended allowing the “health insurance ecosystem to grow organically and [to] keep reviewing the law and regulations as this growth takes root.”17 One study found that more than three-quarters of Ugandans were willing to join a health insurance program.18 However, coverage of community-based health insurance is minimal, as is coverage of any kind of insurance—including private plans.19 A national health insurance scheme bill has been stalled for several years and presently sits with President Yoweri Museveni.20 Community-based health insurance scheme that do exist are expanding in number, but losing enrollees. Between 2022 and 2026, the number of community-based health financing schemes across the country increased by 42 percent, while the number of people enrolled decreased by nearly 11 percent.21 None of this means that community-based health insurance should not happen in Uganda—or that people do not want insurance. It doesn’t even mean that user fees and waivers won’t ever work. But there is highly relevant evidence from Uganda and the surrounding region that it is quite optimistic to describe community health insurance and user fees as central supports for sustainable financing in any sector of the health system. And now for the best-case scenario In the best-case scenario22, the Ugandan approach does exactly what it sets out to do, and so does the Liberian fee structure and revolving pharmacy fund—though I’ve not confirmed that these are in the MoU. In one best-case scenario, Uganda is an outlier, and user fees and community health insurance are not recurrent pillars of self-sustaining financing in other countries’ implementation plans. In another best-case scenario, all countries that include these strategies enjoy success beyond anyone’s evidence-informed wildest dreams: reliable funding generated by health care users fees, great health care outcomes for everyone, no exacerbation of inequities, no crippling household debt. No sold land, repurposed school tuition or high-interest loans. In the best-case scenario, not one of the hundreds of thousands of Ugandans living with HIV receiving antiretrovirals from 491 PNFP facilities misses a refill or leaves care because of user fees or community health insurance premiums. This is the best-case scenario for these people for their own health, and for their families. It is also the best-case scenario if Uganda wants to stay on the path to eliminating HIV as a public health threat. According to the country’s most recent data, 96.5 percent of people living with HIV on antiretrovirals are virologically suppressed. Epidemic control depends ensuring that 95% of people living with HIV know their status, 95 percent of those individuals are on ART, and 95% of those individuals are virologically suppressed. Uganda is still struggling with the first “95"—a frankly abysmal 85.3 percent. If HIV epidemic control and the attendant prevention of new infections, avoidable suffering and premature death matter, the country cannot afford to lose any clients who are currently in care.23 As I write this a couple hours before the polls close for the US elections in the city I live in, I say with soul-deep sincerity: I am rooting for the best-case scenario. I think it’s safe to say that we all are.24 I think it’s also safe to say that if the US and co-signatory governments have inked plans that lead to successful expansion of community health insurance and strategic use of user fees, we all would like to know, now, so that we don’t miss the opportunity to celebrate when success happens. The implementation plan narratives have to enter the public domain. They are the fullest expression of a strategy co-created by two governments. There are assumptions and details that people living in the US and co-signatory countries need to understand that are not available in the MoUs or, to date, in the Congressional Notifications. Some of these details can help other countries that are, as I write this, still working on implementation plans. Others, like a solid count of how many other countries have plans for expanding user fees or health insurance, are important for regional and global health architecture reform initiatives. No matter how this election night turns out, there will be a slew of new Congressional member orientations, briefings and talking points papers in the next few months. Release of implementation narratives should be a bullet point in every context that AFGHS is discussed. These documents can be redacted so that procurement sensitive information isn’t disclosed. There is much more historical precedent for sharing such documents than there is for relying on user fees to fill health financing gaps. Let’s look at the information together so we can hope for the best and prepare for, you know, the other thing. Alt text: A substack first: a bicep selfie! It’s my arm - peachy-white skin, black shirt (flannel, notch neck, too hot for this appallingly balmy November weather, if you’re wondering) and a sticker that says I VOTED 2026. Beige letters on red for I voted. Beige on blue for 2026. You bet I did.25 In your wildest dreams. Subscribe 1 This is a really, really rich 95 page document. There are fascinating ideas and detailed plans in it. It is all worth reading AND I have, in this post, highlighted an instance of content that could pose challenges and certainly posits success of strategies that haven’t worked before. I would love to hear what readers’ see that’s interesting and should be lifted up as something to check for in other implementation plans. I will also shortly be adding a static page to the substack site where implementation plan documents will live. I will put the url into this footnote and it will also be there on emilybass.substack.com by the end of the week. Uganda Implementation Narrative Section 4 April 22 2026 Draft 1.51MB ∙ PDF file Download Download 2 User fees are costs charged for visits, labs, medicines or other health services, usually at the time they are provided. Community health insurance, or community-based health insurance, is what the World Health Organization calls “micro insurance,” which is health insurance targeted at low-income people. 3 As usual (by which I mean always), please prove me wrong. 4 https://smartnewsliberia.com/liberias-ministry-of-health-announces-2025-hospital-service-fees-for-public-facilities/?utm 5 https://moh.gov.lr/news/2025/grand-cape-mount-leaders-residents-embrace-new-community-pharmacy-program/?utm 6 https://www.christianitytoday.com/2026/09/hiv-usaid-pepfar-africa-foreign-aid-cuts-mission-hospitals/?utm 7 https://gh.bmj.com/content/10/11/e021270 8 https://www.who.int/news-room/fact-sheets/detail/community-based-health-insurance-CBHI 9 https://pmc.ncbi.nlm.nih.gov/articles/PMC2827475/ 10 https://pmc.ncbi.nlm.nih.gov/articles/PMC10861328/#b3-jpmph-23-110 11 https://pmc.ncbi.nlm.nih.gov/articles/PMC527704/ 12 Same citation as the footnote 2 - the article is called “Learning from failed health care reform in Uganda.” To which I say: If only. If. Only. 13 There is a whole taxonomy of user fees to be aware of, if not commit to memory. Out of pocket costs are everything that someone pays for themselves. In this Stack, user fees are planned and policy-supported out of pocket costs. There are also out of pocket costs that people pay to buy drugs or receive tests or health care assessments that would be free if the drugs were on the shelves, or the machines or kits were available, or the staff were on site. A user fee is usually designed to be modest, pegged to willingness to pay, and may be waiveable at the point of care for anyone who is unable to do so. The costs for things that would otherwise be free are whatever the market will bear and people either have to pay them or go without. Out of pocket costs for services and stuff that aren’t available in public facilities are different again from bribes or unofficial fees that some health workers may impose, even though most are indefatigable, tireless and tired, and devoted to their clients. 14 For the record—which really is these footnotes—I would give a whole stack of fridge magnets for a systematic analysis of the economic and social impact of the Mass Unemployment Event in AFGHS countries among the very people who used to be able to afford and cover user fees, both for themselves and vast family networks. Locally employed USAID technical staff, house cleaners, caregivers, drivers and technicians were financial anchors for cousins, friends, friends’ children, friends’ childrens’ cousins, teachers, pastors, neighbors and so many other kinds of kin. Aid recipients lost direct funding; many other people who had not been aid recipients, but parts of the elaborate care webs that function as safety nets for so many people, lost crucial support too. And that’s even before we get to the people who worked at the hotels and restaurants and bars where people employed by the US and its implementing partners used to spend disposable income. Those businesses have lost revenue; those folks have lost jobs. It will be some time coming—and someone will have to fund this work—but I do hope it happens. And I hope, as usual, to be proven wrong. 15 https://eprcug.org/blog/how-out-of-pocket-healthcare-costs-keep-driving-ugandans-into-poverty/ 16 Another straight-to-the-point journal article title. Households experiencing catastrophic costs due to tuberculosis in Uganda: magnitude and cost drivers. https://pubmed.ncbi.nlm.nih.gov/32938411 17 https://www.cehurd.org/download/technical-policy-brief-on-community-health-insurance-scheme/?wpdmdl=13661&refresh=6ae9122f5d4ed1793659439 18 https://pmc.ncbi.nlm.nih.gov/articles/PMC10125197/ 19 https://pmc.ncbi.nlm.nih.gov/articles/PMC10861328/#b3-jpmph-23-110 20 https://ugandapost.news/uganda-to-make-health-insurance-mandatory-by-2026/ 21 https://shu.org.ug/download/235 22 With a nod, tip of the stack hat, and wag of the Mercoon tail to a deeply valued reader who told me that I have a tendency to speculate about the worst-case scenarios a little too much of the time. 23 https://news.mak.ac.ug/2026/10/uphia-2025-shows-ugandas-hiv-status-awareness-gap-despite-strong-treatment-outcomes/ As you’ll see in the next footnote, I’ve already written a subSubstack on another topic, so I will be brief with regard to the study referenced in this article. The Uganda Population-Based HIV Impact Assessment, or UPHIA, will never happen in this way again. For more than a decade, PHIAs have been supported by the US government as a way to generate accurate estimates of country progress on key HIV indicators. They are a holdover from the PEPFAR program that was laser focused on ensuring US taxpayer dollars subsidized progress in pandemic control. There may be other population-level surveys and the data may even be publicly released, as the entire set of FY2026 MER data have not. But PHIAs will never happen again. If you’re wondering whether the estimates of HIV progress at country level might get less reliable….you’re not alone. 24 Ooh baby, I hate “we” in almost all forms. But sometimes I go there, when I am looking for company, which I am. Because this Stack moves into the somewhat-uncharted territory of assessing what the implementation plan narratives may suggest about co-signatory countries’ roles and responsibilities to the people living within their borders. The MoUs, specimen and data sharing agreements were templates. Countries’ answers fit into pre-specified questions that did not include, “how are you going to fill financing gaps and stabilize your health system as this plan unfolds?” In contrast, the implementation narratives are open form—the product of co-creation between the two governments. Co-creation can mean lots of things, but nothing leads me to believe that implementation plans are ghost-written by the US government, or that contents were imposed by the US counterparts. Instead, I think the parts of the plans that read like country government initiatives are endorsed, if not initiated by, those governments. For instance, the Ugandan implementation plan narrative describes plans for revenue-generation through fees charged for equipment calibration, repair and maintenance provided through Uganda’s National Equipment Calibration Laboratory, and laboratory accreditation through the Uganda National Accreditation Service (UGANAS), targeting private sector, PNFP, research and academic clients. That’s super specific and also quite ambitious. It doesn’t read like an American idea. There’s also a provision for solar panels, and other stuff that feels country owned and driven. This is where it gets interesting. If co-creation is the case, then both the US and co-signatory governments are accountable for the contents and the outcomes. Most discourse about AFGHS to date has focused on the decisions that America has made, or demanded that other countries make. The AFGHS architects have monopolized the hot seat. As they should, in so many ways. America absolutely created the conditions under which countries needed to come up with health financing strategies to fill unanticipated, catastrophic funding gaps. And with not-too-long a lens, we can look back and see that America is also on the hook for its role in the Bretton Woods institutions that made user fees and health system fiscal austerity conditions of loans during the era of structural adjustment. But in the here and now, it is not at all clear to me that the US is requiring Uganda or any other country to implement specific approaches to sustainable financing. Instead, it is as the authors of that paper up in footnote 6 suggest: African governments have agency. As implementation plans roll out—whether or not the narratives are shared—it will be important to understand what this agency looks like and what it means for people, including the poorest of the poor. And it will be important to figure out how to talk about it safely, respectfully and critically in places other than the literal and metaphorical footnotes. 25 This week’s song is “Once upon a time” by the Moody Blues. (I know, this is gonna be a weird, largely banger-free end of 2026 playlist. HMU with requests.) AND please do watch the video and appreciate the truly amazing opening sequence—a drum kit wasteland, a coupla plastic bags, a bit of sand. Sort of like the hill where fiscal austerity policies that put costs on health care users might go to perish. But then there’s a lady with amazing hair. It’s worth it.
Sphere Entertainment Co. reports results for the quarter ended September 30
FORECAST CHANGESRECOMMENDATIONSThis summary was machine generated from LSEG data November 5 at 03:55 p.m. UTC. All figures in US dollars unless otherwise stated. (For questions concerning the data in this report, contact Estimates.Support@lseg.com. For any other questions or feedback, contact Refi…
This gen’s top 10 PlayStation Studios games
As we near the six-year anniversary of the PS5, we thought we’d dive into our estimates for the top-grossing PlayStation Studios games since the start of the gen. Together, the 10 games we’re covering today have generated over $6.5 billion across PlayStation (84.7%), Steam (14.1%), and Xbox (1.2% via just Helldivers 2). Let’s have a look at the top 10. Spidey and Kratos sequels take the top two spots God of War Ragnarok takes the top spot with $1.4B in revenue via 21.6M copies – 20.1M on PlayStation (75.2% via PS5) and the rest on Steam. Around 27.5% of the copies sold on PlayStation were physical. It’s another PlayStation evergreen seller, too. This year, Ragnarok has already sold 1.1M copies, generating $60M (68% on PlayStation), outperforming new 2026 titles like Gears of War E-Day and Saros. Overall, our estimates show that Ragnarok has been accessed by 6.7M PlayStation Plus players (it was added to the Extra tier about two years ago). So it’s performed that well this year despite subscription cannibalisation. That’s the pull of God of War IP. And that Bautista series on Amazon is going to be massive - bigger than Fallout, I reckon. Next up is Spider-Man 2 with $1.3B across PS5 (over $1.2B) and Steam (nearly $70M). Spider-Man 2 has sold over 19.1M copies overall, so it should pass 20M early next year. Spider-Man 2 is an evergreen title that always spikes around the holidays (mostly concentrated around Christmas week): In December 2023, it sold 2.1M copies, up 20% from November 2023 (the month after release) In December 2024, Spider-Man 2 sold 460K copies (natural decay), up 60% from November 2024. Despite the Steam version launching in January 2025, it still sold more copies – and made more revenue – the month before. In December 2025, it sold 328K copies, up 30% from November 2025. This year’s December and Christmas will be somewhat limited by Spidey’s February 2026 addition to PS+ Extra, where 6.3M people accessed it for the first time. While subscription inclusions always cannibalise premium revenues to some extent, Spider-Man 2 did manage to sell 578K copies in August 2026 – the most its sold since Q1 2024, following hype from the Spider-Man Brand New Day movie. Want more free estimates and insights in your inbox twice a week? Subscribe below! Subscribe God of War Ragnarok and Spider-Man 2 continue to be huge evergreen tentpoles for Sony. Together, both titles have sold 3.4M this year (2.3M for Spidey and 1.1M for Ragnarok), generating a combined $172.9M ($115.8M for Spidey and $57.1M for Ragnarok). Again, some premium games would take a leaf out of Kratos’ book (not Spidey’s!) and would kill for these numbers in year 1. And we can see why Sony wants to take a leaf from Steam’s book, killing physical to get higher margins from catalogue sales, ensuring they get their cut, and having more control over supply and demand (and pricing for their first-party titles). Hot rods, hellpods, and horizons Gran Turismo 7 takes #3 this generation with $841.9M in revenue via 12.7M copies sold. For more info on GT7, you can check out our write-up from earlier this week. Around 1.1M people have already played GT7 this month, less than six days in. Next up – at #4 – is the first second-party game on this list. Helldivers 2 has generated $786.3M via 23M copies sold across Steam (66.1% of the copies), PS5 (25.7%), and the 1.5-year-later Xbox port (8.3%). And there are plenty of players very dedicated to the Super Earth cause, as over 4M folks have played Helldivers 2 for over 100 hours, while 462K played for over 500 hours. That dedication to democracy is pretty topical… Anyway, Helldivers 2 still attracts about 700K players per day (more if there’s a significant update), and its August addition to PlayStation Plus Extra has led to 1.6M new players overall. This year, Helldivers 2 has sold over 2.5M copies, generating $81.1M in revenue. It’s another evergreen hit for Sony, and draws in engagement numbers similar to Arc Raiders. The Helldivers 2 model, in my opinion, should be the way PlayStation approaches its live-service and second-party releases. Want more free estimates and insights in your inbox twice a week? Subscribe below! Subscribe Horizon Forbidden West rounds off the first half of the top 10, generating $485.8M. That said, PlayStation completely stifled Horizon Forbidden West’s revenue by adding it to PlayStation Plus way too early (one year after launch). You can see the revenue drop-off clearly in our platform: As you can see: Forbidden West was still a healthy catalogue earner right before it was added to PS+ Extra, making about $1.23M a week on PlayStation across late 2022 and into January 2023. After it was added to Extra_, Forbidden West_’s weekly revenue halved to around $610K, basically overnight. Excluding launch month, Horizon Forbidden West generated about $67.2M on PlayStation in the period before the PS Plus addition. In the same period after it joined the service, that fell to $28.1M, a 58% drop. So, PlayStation didn’t trade a little bit of premium revenue for subscriber value here. It gave up well over half of it, and it cut momentum instantly for one of its premier franchises. Could you imagine the kind of cannibalisation if it launched day in date on Extra? Want more free estimates and insights in your inbox twice a week? Subscribe below! Subscribe And the cannibalisation wasn’t a temporary blip that bounced back once the game left the service in September 2024. By then, 19 months on PS Plus had already hoovered up most of the install base that would have bought it, so there was barely a premium audience left to monetise. PlayStation even added it back to PS Plus on October 21 this year, and sure enough, weekly revenue dropped again (by around a third); though, the numbers are small now that Forbidden West is nearly four years old. Worth the trade-off. The usual suspects, platformers, and an Asia-driven second-party hit As for the rest of the list: Ghost of Yotei has now generated $410.1M via 5.5M copies on PS5. Yotei popped off a bit a few weeks ago due to a content update, which we covered here. The Last of Part Us I, a remake that we covered here, has generated $341.3M in revenue (67.2% via PlayStation) via 6.4M copies. It was also added to PS+ Extra about two years after launch, where 7.8M people accessed it for the first time. Ratchet and Clank: Rift Apart has made $334.9M (93.6% via PlayStation 5). It’s now passed 5M copies sold overall. It’s sold 250K copies this year, generating $13.5M in revenue. Time for another Ratchet? Stellar Blade has generated $316.9M via PS5 (59.7%) and Steam (40.3%). However, the share of Stellar Blade’s 5.4M copies sold is far closer (50.4% on PlayStation, 49.6% on Steam) – despite the Steam version releasing a year later. China, Taiwan, and Hong Kong account for 48% of Steam copies and 35% of PlayStation copies (about 41% overall). These markets are regionally priced lower than others, hence the difference. Astro Bot rounds out the top 10 with $292.6M in revenue via over 4.7M copies sold. We covered Astro’s recent performance here, covering how Astro Bot is another evergreen seller and has been a hit with families. Want more free estimates and insights in your inbox twice a week? Subscribe below! Subscribe Even these bottom five games have generated a combined $281.7M this year in catalogue sales. PlayStation wants those numbers to be bigger in the coming years, which is one of the reasons it’s killing the disc (alongside the better margins it and publishers get through digital). No more used discs means more D2C revenue for PlayStation. On that note, we recently chatted to the New York Times again about PlayStation’s digital future, so keep your eyes peeled for that! The last word Reply to this email – or reach out here – if you have any feedback for the newsletter – or want to request a game for us to cover. Want to see why these companies (and many others) are subscribed to Alinea? Get a free platform trial! [Alinea Analytics boasts the most accurate PC and console estimates in the business. Game makers use our platform to understand their audience, keep an eye on the competition, monitor sales trends, and spot new opportunities. We equip game studios and financial institutions with accurate data and the confidence to make smarter, data-driven decisions. Want to talk about all things games market data? We’d love to chat!]
Drama in Every Scroll: The Rise of AI-Generated Entertainment
Person holding phone scrolling (Photo credits: Jada Richard) One scroll reveals a shocking betrayal. The next introduces a secret millionaire. Before long, a cliffhanger leaves viewers searching for the next episode. Across TikTok and Instagram, AI-generated videos are filling social media feeds
Dallas business giants help bankroll $360,000 push for homelessness tax
Voters will decide Tuesday whether to increase the county property tax rate indefinitely to generate about $100 million a year for homeless services.
South Texas Health System (@stxhealthsystem)
Investing in Tomorrow’s Healthcare Workforce: With healthcare occupations projected to generate approximately 1.9 million job openings annually through 2035, according to the U.S. Bureau of Labor Statistics, preparing the next generation of healthcare professionals has never been more important. Recognizing the critical role education plays in workforce development, South Texas Health System continues to invest in local colleges, universities and nonprofit organizations that help cultivate future healthcare professionals, including the Texas A&M University Higher Education Center at McAllen (@tamumcallen). As part of its longstanding partnership with Texas A&M University, STHS has once again contributed $5,000 to the university's McAllen campus. The donation will support the campus' Bachelor of Science in Nursing program, which launched in January 2026, while helping students pursue careers in healthcare. This marks the third consecutive year STHS has provided financial support to the Texas A&M University Higher Education Center at McAllen. The contribution will help offset educational expenses through scholarship opportunities while supporting efforts to expand allied health programs and enhance workforce training initiatives designed to meet the growing healthcare needs of the region - @stxhealthsystem on November 7, 2026
Itch Is Being Flooded By AI-Generated Garbage
'The number of game pages being created per-day has doubled in the past 2 months'
AI-generated political ads spiked in 2026, but campaigns still prioritized other means of messaging
For two election cycles, misinformation and election experts have wondered: Will content generated with artificial intelligence dominate races and mislead voters?
OpenAI AI Pipeline Generates 948 Linux Root Escalation Exploits in 30-Hour Run
OpenAI's AI pipeline reproduced 1,724 Linux vulnerabilities and generated 948 working local privilege escalation exploits for $1.2 million.
Real-World Weight Journeys: Exploring Health Experiences to Improve Care
(Feature Impact) A number on a scale tells only part of the story. Living well is also about having energy, feeling your best and enjoying a good quality of life. Yet each person’s path is different, and lifestyle changes, medicines and other approaches to managing weight can affect health in different ways. TNCMS.AdManager.render({region: 'fixed-big-ad-top-asset', slot: 1, fold: "above"}); No two weight-management journeys look the same. Some people are taking their first steps toward healthier habits. Others are balancing health conditions, caring for family members, coping with stress or exploring new treatment options. Along the way, they may find support that helps them succeed or encounter obstacles that make progress more difficult.These stories provide valuable insights into what it takes to improve health in everyday life.That’s the idea behind the American Heart Association’s Healthy Living BEYOND Weight Study. By learning directly from adults across the country, researchers aim to better understand the challenges, motivations and factors that shape weight and health outcomes over time. The goal is to generate insights that can help improve support, inform care and empower more people to live healthier lives.What Factors Influence WeightNearly 1 in 3 U.S. adults are overweight and 2 in 5 are obese, according to the National Institutes of Health. Weight is shaped by many factors, including:Genetics and hormonesAccess to healthy food, safe places to exercise and healthcareChronic stress and mental healthMedications and metabolismCommunity conditions, as where you live can influence your ability to live a healthy lifeHow Joining a Study Can Make a Difference Led by the American Heart Association, the Healthy Living BEYOND Weight Study is open to U.S. adults with a BMI of 25 or higher, including those who have tried lifestyle changes, weight-management medicines or weight-loss surgery. By sharing information about their health and daily lives, participants can help researchers better understand how to improve care.Interest in newer weight-loss medicines, such as GLP-1s, has grown rapidly. While these treatments are helping many people, researchers are still learning about their long-term effects and how they fit into everyday life. People who currently use or previously used a GLP-1 may be eligible to participate and help generate insights that could improve care for others.Reasons to Join This StudyBy joining this study, participants can help researchers better understand the long-term impact of treatments, identify what helps people succeed and uncover the challenges they face along the way. The information they share can help fill important gaps in research, shape better and more compassionate care and guide future health recommendations.According to the Pew Research Center, 31% of U.S. adults report they’re online “almost constantly.” The study is conducted entirely online, making participation convenient and easy. It can be completed from home on a schedule that works best for each participant.Consider these reasons to participate:Your story matters. By participating, you may help build knowledge that can improve care, guide health recommendations and help people live healthier lives.It’s easy. The study is conducted entirely online, making it simple to join and stay involved at your own pace.It’s safe and respectful. All data is collected with your informed consent, protected by privacy safeguards and handled according to rigorous ethical and scientific standards.You won’t be alone. Millions of people are navigating weight and health challenges. By sharing your journey, you can help researchers better understand what works, what support is needed and how to shape better and more compassionate care for others.Learn more and consider signing up at Heart.org/GoBeyond.Photo courtesy of Shutterstock
AMC Entertainment Holdings, Inc. reports results for the quarter ended September 30
FORECAST CHANGESRECOMMENDATIONSThis summary was machine generated from LSEG data November 4 at 10:49 p.m. UTC. All figures in US dollars unless otherwise stated. (For questions concerning the data in this report, contact Estimates.Support@lseg.com. For any other questions or feedback, contact Refi…
WHO’s Trillion-Dollar Climate-Health Case Rests On Taxing Fossil Fuels
Scaling up six climate and health measures worldwide could prevent 1.6 million deaths a year and generate $3.9 trillion in economic benefits annually, the
Business owners call city’s plan to replace parking garage with apartment building part of ‘pie in the sky’ vision for downtown
The Seneca Street parking garage is in the middle of a tug of war. Voices are AI generated. The Ithaca Voice is not responsible for mispronunciations. The Ithaca Common Council is moving ahead with plans to try to replace the decaying garage with a housing development without a parking requirement. Downtown Ithaca businesses are fighting back. […]
AI-generated 'slopaganda' in political ads puts internet platforms on alert
Tuesday's midterm elections follow record spending on AI-generated political ads.
76ers successful offseason ignites booming business opportunities
The Philadelphia 76ers generated unprecedented excitement in the offseason, and the on-court excitement is spilling into a massive year off the court.
Saved by Trump: What Hegseth’s political survival means for Europe – European Council on Foreign Relations
An effort to impeach Pete Hegseth has stalled. The Republican Party has closed ranks behind him out of loyalty to Trump, and Europeans must prepare for two more
Missouri announces $55 million for rural health care improvements
Governor Mike Kehoe, in partnership with the Missouri Department of Social Services (DSS), announced the upcoming launch of more than $55 million in new
Is Elon Musk setting his sights on Hollywood?
Elon Musk has already made his mark in space, tech and electric cars. Now, he may be entering Hollywood with a reported investment in Skydance and an AI-generated "Odyssey."
Illumina selected to help bring precision medicine into everyday healthcare in Singapore
Illumina, Inc. (Nasdaq: ILMN) announced it has been selected to provide whole-genome sequencing services for the SG-INSIGHT study, a cohort under Phase III of Singapore's National Precision Medicine (NPM) programme. Expected to include approximately one in 10 Singapore residents, or around 450,000 individuals, the study is designed to generate evidence from genomic and health data to help inform preventive approaches to healthcare.
Strategic Value and Economic Evidence for European Big Science Research Infrastructures
Researchers present an economic evaluation framework showing how European Big Science infrastructures generate systemic societal value beyond direct scientific discoveries.
AI-generated political ads spiked in 2026, but campaigns still prioritized other means of messaging
For two election cycles, misinformation and election experts have wondered: Will content generated with artificial intelligence dominate races and mislead voters?
Rhode Island stays unbeaten, but early shooting problems linger
URI guard Dylan Williamson led the game in points with 18. Williamson’s self-generated 11-2 run late in the game all but sealed the win for the Rams.
MD Entertainment sets 2028 sequel to ‘Pabrik Gula’ and three Imax films for 2027
MD Entertainment plans to release a sequel to its 2025 horror hit ‘Pabrik Gula’ in early 2028 and has three Imax films planned for 2027, executive Astrid Wienardi said at Taiwan Creative Content Fest in Taipei.
Bonus Features – November 8, 2026 – 48% of Americans have used AI to review their health insurance options, 68% would independently verify AI-generated medication details, plus 34 more stories
Welcome to the weekly edition of Healthcare IT Today Bonus Features. This article will be a weekly roundup of interesting stories, product announcements, new hi
RETROFIT Platform to Present AI-Powered Immunotherapy Innovations at Science for Health 2026
RETROFIT Platform to Present AI-Powered Immunotherapy Innovations at Science for Health 2026 / AI, Biovia Science for health, cancer, immunology, OncoDaily,
AI-generated political ads spiked in 2026, but campaigns still prioritized other means of messaging
For two election cycles, misinformation and election experts have wondered: Will content generated with artificial intelligence dominate races and mislead voters?
A self-charging toothbrush that generates electricity to kill bacteria while you brush
A lot of time and effort goes into toothbrush technology, whether changing bristle angles or tweaking and improving electric models. No matter the developments, they all essentially still do the same ...
November Pixel Drop brings Gemini Intelligence to Pixel 10 family
Spruce up your home screen with expanded custom icons and AI-generated widgets.
Chinese scientists make toothbrush that uses electric shocks to reduce plaque
The self-charging devices can generate tiny currents designed to disrupt the spread of bacteria in the mouth.
GTA 6 Could Be the Biggest Entertainment Launch in History
Grand Theft Auto 6 has generated $1.18 billion in presales ahead of its Nov. 19 release, setting the stage for a historic launch.
Elanco Animal Health (ELAN) Stock Still Looks Cheap Following Its 141% Run
Elanco Animal Health has seen its stock climb in recent years, helped by steady demand for pet care and new product launches, which naturally raises a valuation question for anyone looking at its cash flows today. With the share price moving and the business investing in new therapies and research hubs, the issue is whether the current market tag still lines up with the cash the company can generate over time. Over the past 3 years, Elanco Animal Health has returned 141.0%, which puts a lot...
Is science possible without scientists?
Systems that generate and test their own hypotheses and then write up the results are no longer a thought experiment.
OpenAI: ChatGPT Search Is About 20% of Google’s, 250 Million People Speak With ChatGPT, and Chat Is Merging With Work
OpenAI says ChatGPT growth is accelerating. The company added 200 million users over just the past two months, jumping from 1 billion to 1.2 billion weekly active users in 60 days. Its search volume, it says, is approximately 20% of Google’s. Its users create 1.5 billion images with it per week. And its voice mode, between dictation and speaking with ChatGPT, now has 250 million combined weekly active users. ChatGPT consumer product lead Adam Fry told me this during a brief fireside chat at an OpenAI-hosted dinner in New York City on Monday night. “The growth is just going big,” he said. During our conversation, Fry also revealed plans to merge ChatGPT’s Chat and Work modes (so that confusing toggle up top will soon go away), agreed with feedback that ChatGPT-created restaurant signage looks too uniform, and addressed the cost to serve its personal assistant Dots. Here’s a look at our full conversation, lightly edited for clarity and length. We also cover image generation, interactive interfaces, advertising, education, and public unease about AI: Alex Kantrowitz: OpenAI has analyzed ChatGPT’s search volume and compared it with Google’s. What did you find? Adam Fry: ChatGPT has been growing quite quickly. ChatGPT’s volume of search-like queries is now roughly one-fifth the volume of queries of Google. It’s a pretty amazing statistic when you think about it, mainly because we started just about a year and a half ago. It’s hard to remember this, but ChatGPT at a time didn’t have any up-to-date information. You’d ask a question, it would say something like, “It’s past my training date,” and nobody had any idea what that meant. You’re saying ChatGPT’s search volume is one-fifth of Google’s. Bing’s share of the search market is around 5%. Does that make you multiple times larger than Bing? To say that more directly, ChatGPT has gone from one billion to 1.2 in just the last two months. That’s roughly 100 million users in 30 days, and another 100 million in another 30 days. The growth is just going big, and we’re staying very focused on how fast ChatGPT is growing. What counts as a search? I might have 20 prompts back and forth in a ChatGPT conversation. Does each one count as a query? Story continues below… A MESSAGE FROM OUR SPONSOR Move upmarket without a rebuild Moving upmarket means saying yes to what enterprise buyers ask for first: SSO, directory sync, and audit logs. WorkOS gives you all three, so your team keeps building the product instead of the checklist. Get enterprise-ready. Continued from above…. Adam Fry: What people came to ChatGPT for to start, if you go back about two years, is really writing help and coding help. Those wouldn’t be things that you really search for. What we’ve seen over the last year is people have grown into all these other topics. Things like you’re looking up a person or people or a place or a thing, and it requires up-to-date information. That’s a key element. Another big part is finance questions or health questions, where you really want to make sure it’s up-to-date information that’s quite factual, and we’ll do a web search for those questions. It’s basically anything that a user would have traditionally gone to a traditional search engine for, but is now deciding to go to ChatGPT for. Does each conversation with a search embedded count as one search, or does every question that requires a web search count? Every time you ask a question and go search the web, that’s a search. You used to work at Google. How would you say the nature of search is changing? One of the things that people really love about ChatGPT is this personalization and this understanding of the broader journey. If you look in the past, people would go for a Q&A box, and you’d ask a one-off question, like how tall is the Eiffel Tower. But there’s so much context in our lives around, “Maybe I’m taking a trip to Paris.” It’s actually helpful for ChatGPT to respond, “Here’s how tall the Eiffel Tower is, but I know you’re going on a trip to Paris.” It’s that ability for people to actually maintain context over time that has led them to start using ChatGPT in this way. You’ve also announced 250 million weekly active users of voice input, including dictation and conversations with voice mode. We are at 250 million weekly active users. What’s amazing about this is, if you look at those 250 million, what we’re seeing is it’s actually also incremental to the product. It’s no longer just a novelty. People aren’t just trying out voice. We’re seeing them use voice input day to day in their daily life, and it’s grown so quickly. Those 250 million users are using voice input, and that could just be a quick question or a long conversation. We’re seeing both behaviors. We’re seeing people just not want to type. You just hold it and start talking to it, or it turns into a longer conversation where people just sit with it. The big reason for this is the frontier capabilities of our models that we’ve shipped. We shipped what we call GPT Live 1, and then we shipped GPT Live 1.1. The big change with this is that it’s much more natural to speak with. It’s something we call backchanneling and interruptibility. Mhhhm… What you just did there is what the model does, because it’s really good at having a bidirectional conversation. That push to the frontier—we were the first to really release this at scale—has made it so much more natural for people to chat. That’s still only about 20% of the user base. From the outside, that looks small. Why is it exciting from the inside? It’s very exciting for a few reasons. We see from the data that when people start using voice, they stay around using voice. One of the things, transparently, we can do a better job of is bringing more people into discovering it. We see that the number of people who discover it could be a lot higher. But once they do, it’s a really new way for people to interact with AI. We’ve made a lot of improvements to it too, where we’re just going to see the number go up. You have background mode, so now by default, if you close the app, it’ll show, “Hey, the conversation’s still going.” If you want to walk around the house or you’re putting away the groceries, you can still have a chat. That kind of continuity has also changed how much people use it. Dots launched on September 29 and is about a month old. How’s it doing? It’s doing great. We talk to people about their Dot, and the first thing that everyone says is, “I love my Dot.” One of the reasons we’re seeing this is the proactivity, its ability to reach out to you and figure out things. The biggest use case I see all the time is, “Did I forget something today that I was supposed to do?” You can just say to your Dot, “Remind me of things at the end of the day that I may have forgotten. Somebody emailed me or messaged me,” and it’ll do that. This Dot changes the paradigm of the relationship with AI, where it’s actually helping you and giving you time back. You’re more conservative with permissions than some competitors. I tried to give my Dot my credit card, and it wouldn’t take it. With the creator of OpenClaw in-house, why are Dots’ permissions more limited? This is a space where we want to be very thoughtful and conservative because it’s a new space where you’re entrusting your Dot to take care of things on behalf of you that matter and are meaningful. We’ve just talked about how you go to this 1.2 billion user growth and asking questions. Now we’re asking people, “Can you ask ChatGPT or your Dot to help get things done?” But when you ask it to help get things done, it’s a whole new level of trust. We’ve built up a tremendous amount of trust in giving the right answers to your questions, and we want to make sure that when we build this new product, it has a high degree of trust. It’s a long game. We think this is going to be a new market for a very long time, and we want to make sure that we’re being this trusted player in the market to start. I initially thought Dots would be available on my $20 plan, then realized I had to spend $100 a month to get it. I upgraded, but I’d like to downgrade at some point…. We hope to keep earning your business and make the value good enough. It’s a really good point. ChatGPT’s goal more broadly, which I think is unique for us in the market, is we are focused on bringing intelligence to everyone safely across the entire world. For Dots in particular, there’s no difference. We don’t have anything to share tonight about the date of when Dots will go to a broader set of users. But you can rest assured we’re working very hard, and there are a couple things we have to get right. Over time we’re going to work on more efficient, agentic models that are able and capable of doing things for you. The first one is, right now we wanted to make sure that your Dot is actually really helpful. We started with some of our best models, but over time we’re going to work on more efficient, agentic models that are able and capable of doing things for you. The second thing is around proactivity. We’re still dialing in: How much do I message you to help you get things done? We can always play around with that to understand how much usage should a user use to have a successful Dot. We’re going to work on both, and our goal and ambition is to bring it out to all users. How much background computing does a Dot require? I’ve read estimates that serving a $100 subscriber might cost OpenAI $3,000 in compute, and mine seems to read every email that arrives. How often is it checking connected data sources? Right now, Dots are on the compute-heavier side, and this is one of the things we want to make sure that we can dial back over time. But the goal is to give you the best product. This is our premium, always-on personal assistant. Once we nail that, we’ll figure out how to dial back the compute needs. The thing we’re seeing also from our models, as we train frontier models, is just how—I can’t even keep up with how quickly we have a new model, and each new model is more efficient. If you looked at 6.1 Sol when it came out relative to Astra, much more efficient. I’m very excited about the next set of models we have coming too that’ll be even more efficient that we can use. Elon Musk said the cost of serving Grok Bot was unsustainably high relative to revenue. Is efficiency the key to winning against competitors, or is there more to it? There are a couple of factors that go into it. One is the cost side, but the other is the revenue side. On ChatGPT and on our consumer business, we’ve been extremely proud of our ability to diversify different revenue streams in a way that’s growing really fast. To give you another stat, we announced several months back that we had passed 50 million subscriptions, and the number has grown considerably since then. On ads, within 200 days, we reached more than a billion in ARR, and that business is growing extremely quickly. We also have credits. Rather than paying for subscriptions, users can buy more credits. Between credits, subscriptions, and ads, I’m confident that the value of a Dot is going to be able to pay for itself. Elon has subscriptions too. This is clearly an expensive product to serve. One thing we continue to bet on at OpenAI and ChatGPT more broadly is that the models will continue to get much better and much cheaper, way faster than any of us think. If you look back at the historicals on it, it continues to be true. From what I’ve seen, I see no slowing down of that. What is Meta doing right with Muse? It has spent a lot of time atop the App Store charts. There are a couple of things they’ve done well. The first is people have been craving simplicity in their products. One of the things we have stated publicly as well is, at times AI products can be too complex. We’ve announced we’re merging ChatGPT’s Chat and Work. We’re making it much more simple in the products. You don’t have as many toggles or sliders between efforts and different model pickers. One of the things they’ve done well is this simplicity. You just go in and you can ask a question. You don’t have to think too much about what you’re doing. That’s one thing that seems to have resonated with users, which we also believe in. Second, there’s something really nice about being able to access your agent across many different channels. We just announced and launched Dots on iMessage. Whether you talk to your Dot on email or iMessage or within the ChatGPT app, the ubiquity in getting your assistant out there is going to be key. Those are two things that, if I had to be nice to our competitors, I would say were two big ones. So Alexandr Wang’s meme-tweeting strategy isn’t something you’re going to emulate? I have a different tweeting style. ChatGPT still asks me to choose between Chat and Work, even though some people call this technology AGI. Will that distinction go away? Couldn’t agree more. We have to solve this. Asking users to choose — we’ve heard repeatedly from all of our users it’s too much to understand. When should you go to Chat? When should you go to Work? It’s solvable. There’s real research to solve to make sure the models can understand what your intent is. Are you asking for a fast, quick reply? Are you asking me to go do a long agentic task? We’re going to solve it, and the plan is to bring Chat and Work together. So one interface will work out whether I’m asking for a conversation or a task. When? Coming soon. You told me the majority of ChatGPT’s 1.2 billion users are using image functionality. What are they doing? Today, 1.5 billion images are created per week. It’s hard to even wrap my head around that number. They’re doing a wide range of things. One of the most interesting things they’ve started to do is really use it for productivity use cases. The first thing it started with—I don’t know if you saw the ’80s trend, but it was quite fun. You could take a photo of yourself and say, “Put me and my family in ’80s outfits.” I did this for my family, and it was a really fun poster. But what we’re also seeing is businesses for their menus, or posters for birthdays. People are using it almost in a productivity-like fashion to create visual diagrams of what they would like to see. We’ve actually brought the latency down on images as well, so it’s gotten a lot faster. It went from a very high number of seconds to getting much faster. As it comes down even further, the number of images people are creating and the number of use cases is going to grow a lot. My feature request: When a restaurant makes a menu or sign, prompt it for more specificity so it doesn’t look like every other AI-generated restaurant sign. Or offer a shuffle button for a different style. I agree with the feedback, and we’ll take it to the team. I’m seeing ChatGPT generate little interactive interfaces within its answers. What’s the direction for Intelligent UI, and how are people using it? I am extremely excited about Intelligent UI. If you go back a couple years, these chat apps were all text, and now that’s changing. They’re going to be visuals. Intelligent UI and our first attempt at this with GPT-6 Intelligent UI is really just the beginning. As you go to the extreme, what you can imagine is, let’s say you’re using voice mode, and you just say, “Show me how offside works.” Immediately it should show you a visual diagram, and you say, “No, I don’t quite understand it.” It should just repopulate. That’s where the future of this technology goes. It’s almost like you’re talking to a canvas that will update and change. People are finding it helpful for a lot of things. My favorite one is—it’s hard to admit that I had no idea how hearts work. The last biology course I took was in high school. I just asked it, “How does the heart work?” and it instantly gave me a beautiful interactive diagram of where blood flows and how it goes through. I’m really, really bullish on this for learning in particular. You’ve described useful applications in finance, health, and learning, and ChatGPT has 1.2 billion users. If people are getting so much value, why is public polling on AI so negative? The reality with AI is it is going to change the nature of how work gets done. For a lot of people, that is something that can feel scary at times, and we’ve all felt that. But I remain confident that when people actually use the product and they use AI, it very quickly changes how they perceive it. We’re at 1.2 billion, but there are still a lot of people who haven’t used it. The more people use it, get familiar with it, how it can actually help you in your life, it’s going to feel a lot less scary. Big Technology is a reader-supported publication. To receive new posts and support our work, please consider becoming a paid subscriber. Thanks!! Subscribe
OPKO Health (OPK) Stock Looks Pricey As Focus Turns To Its 58% Five Year Fall
OPKO Health has climbed in 2024 yet carries a much longer track record that includes a steep multi year decline, which puts a spotlight on whether the current share price lines up with the revenue story. With the stock trading at US$1.72, the key question is how that tag compares with what the business actually generates in sales. OPKO Health shareholders have seen the stock fall 58.4% over the past 5 years, so any reassessment of its worth now hinges heavily on what its revenue base can...
‘Watergate-level repudiation": 1974 GOP wipeout echoes through 2026 results
Phantom Blade Zero made $223M on Steam and PS5 in five days
Phantom Blade Zero was always going to be a hit. We’ve been banging on about it for months now. Well, the results are in, and Phantom Blade Zero has indeed been a hit. Yesterday, S-Game reported that Phantom Blade Zero has sold 4M copies. As of this morning, our estimates show that Phantom Blade Zero has generated $223M via 4.3M copies sold across Steam (3.1M) and PlayStation (1.2M). This instantly makes Phantom Blade Zero this year’s #10 new 2026 game by premium revenue across Steam, Xbox, and PlayStation – and without an Xbox release to boot. Want more free estimates and insights in your inbox twice a week? Subscribe below! Subscribe Combined, China, Taiwan, and Hong Kong account for 55% of Phantom Blade Zero’s copies sold – 56% of copies on Steam and 50% on PlayStation. But revenue is slightly different. Phantom Blade Zero actually made more revenue outside of China However, due to regional pricing, China, Taiwan, and Hong Kong account for a lower share of revenue, 45%. The three countries account for 40% of Phantom Blade Zero’s revenue on PlayStation, and 47% on Steam. This is due to regional pricing, which you can easily check in our platform: Using the $59.99 USD base price as a starting point, we can see that Phantom Blade Zero costs the equivalent of $40.31 in China (-32.8% of the US price) and $41.80 in Hong Kong (-30.3%). So while Chinese culture is at the heart of Phantom Blade Zero (in terms of theme and player base), it’s actually making more money in non-China markets. In fact, markets outside of China, Hong Kong, and Taiwan account for $123M in Phantom Blade Zero revenues via 2M copies. Even when we remove revenues from these markets from the analysis, Phantom Blade Zero remains a top 20 new 2026 title by revenue across Steam, Xbox, and PlayStation. Want more free estimates and insights in your inbox twice a week? Subscribe below! Subscribe In other words, Phantom Blade Zero is a global hit. It’s not all China – or even majority China, when it comes to revenues. The China spring board helped, but a successful State of Play and – more importantly – positive reviews helped this one land in other markets. Quality sells. China was hyped from the start, but Western players needed more convincing As we wrote back in August, China was always going to show up early for Phantom Blade Zero. Our daily Steam revenue data shows just that, and we can see when S-Game’s banging RPG won over players outside of China: On the day Phantom Blade Zero’s Steam pre-order button went live in mid-August, China accounted for nearly 70% of Phantom Blade Zero’s Steam revenue. The shares hovered around 68% throughout August. This is the hometown-hero effect we’ve covered in the past, with the home market committing first – almost sight unseen – on national pride and a lush-looking trailer alone. Then things get even more interesting. Following the State of Play on August 18, US daily revenue more than doubled (from $72K to $146K), China’s daily take nearly quadrupled ($237K to $892K), and the rest of the world’s revenues also more than doubled. As China spiked so much harder than the others, its share of revenue hardly moved, holding at around 68%. So the by-all-counts-awesome State of Play got non-China markets and the West interested (you can see daily spend jump), but it didn’t move the needle for overall revenue shares. Positive reviews were the Western tipping point. US daily revenue went from $106K on October 25 to $230K when the embargo lifted on the 26th, to $463K on the 27th, to $899K on the 28th. So nearly 8.5x more revenue in four days, boosted by the positive reviews and subsequent word of mouth. When Phantom Blade Zero launched on the 29th, things hit critical mass. On launch day, the US and the rest of the world combined out-earned China for the first time in Phantom Blade Zero’s whole pre-order history. You can see this unfolding pretty nicely in the revenue shifting shares, too. China’s lifetime revenue share sat at 68% in August and was still 65% as late as October 25th, but it dropped to 45% by November 2. Over that same period, the US nearly doubled its share from 10% to 18%, and the rest of the world climbed from 25% to 38%. Want more free estimates and insights in your inbox twice a week? Subscribe below! Subscribe That’s not to say that China sold less – far from it. The West and non-China markets just showed up later, won over by the reviews and word of mouth. However you look at it, Phantom Blade Zero has become one of this year’s highest-grossing premium games. Daily volume seems to be decelerating a bit (which is natural), so subscribe below for more updates on performance. Speaking of performance and deceleration… Gran Turismo 7 is one of PlayStation’s biggest earners While games like Ghost of Yotei, Helldivers 2, Astro Bot, Wolverine (2.7M now, by the way), and even Marathon and Saros tend to get all the headlines (we hold our hand up there, too!), there’s one PlayStation game from the past five years that’s earned more than all of these games: and it’s one that’s rarely talked about in enthusiast circles. Gran Turismo 7, which launched in March 2022, has sold 12.7M copies. This amounts to $840M in revenue, second only to Spider-Man 2’s $1.3B – if we’re talking PlayStation first-party for this generation. Gran Turismo 7 still brings in around 3M players every month (and between 400K and 700K active players per day). It’s also an evergreen seller every year. For example, Gran Turismo 7 generated: $189.7M in 2023 via 2.9M copies $161.3M in 2024 via 2.7M copies $119.1M in 2025 via 1.7M copies This year, Gran Turismo 7 has already sold 1.3M copies, generating $74.7M And there’s more laps to come Every December is comfortably GT7’s biggest month of the year (except launch), and the gap is widening there. December generated 2.1x a normal month in 2023, and by 2025 that had grown to 2.8x. Want more free estimates and insights in your inbox twice a week? Subscribe below! Subscribe As the typical months cool off with age, Christmas always holds strong, so the holiday period is becoming a bigger slice of Gran Turismo 7 yearly revenue. For Gran Turismo 7, the week around Christmas does 3x to 5x a typical week – three years running: Christmas week 2023: $14.7M (4.6x the year’s median week) Christmas week 2024: $9.3M (3.3x) Christmas week 2025: $8.5M (4.6x) These Christmas peaks happened at the full $59.99 (Gran Turismo 7 wasn’t discounted at all in December 2023 or December 2025). And although there was a discount late in December 2024, GT7’s peak week that year still happened at full price. You can really see why PlayStation hasn’t added this one to PlayStation Plus, eh? Say it after me: Subscriptions cannibalise premium revenue! On that note… Let’s take a quick look at how Gran Turismo 7 is doing versus its nearest competitor, Xbox console exclusive and long-running sim racer Forza Motorsport (released in 2023 as a reboot for the franchise, about 19 months after GT7). Forza Motorsport has sold around 1.3M copies across Xbox (75.4% for Xbox console and PC) and Steam (24.6%), grossing $89.9M across those platforms. Launch aligned, and on just PlayStation, Gran Turismo 7 had sold 10.2M copies, generating $676.1M, by that point. In other words, Gran Turismo 7 has sold the same number of copies this year as Forza Motorsport has sold since launch. When all is said and done, Gran Turismo 7’s 2026 revenues will have lapped Motorsport’s lifetime, too. It’s worth noting that Forza Motorsport was not released on last-gen consoles, and under a quarter of Gran Turismo 7’s revenue has come from PS4 consoles. Critically, Forza Motorsport is also on Game Pass, where nearly 7M players have accessed it. Meanwhile, the Forza Horizon series has been performing incredibly in terms of revenue. This year’s Forza Horizon 6 has generated $583.7M across Xbox and Steam despite Game Pass cannibalisation, and last year’s Forza Horizon 5 PlayStation port has generated $383.5M on PS5 alone. So two questions, then: How well is Forza Horizon 6 going to do when it launches on PS5 in January? Hit subscribe to get that in your inbox in January (which is in two months somehow!?) Subscribe 2. Open-world arcade Gran Turismo when? Also, if you like arcade racers, go and play Star Wars Galactic Racer. It rules. Like GOTY material, seriously. The last word Reply to this email – or reach out here – if you have any feedback for the newsletter – or want to request a game for us to cover. [Alinea Analytics boasts the most accurate PC and console estimates in the business. Game makers use our platform to understand their audience, keep an eye on the competition, monitor sales trends, and spot new opportunities. We equip game studios and financial institutions with accurate data and the confidence to make smarter, data-driven decisions. Want to talk about all things games market data? We’d love to chat!]
Sony Pictures Home Entertainment to Release Horror Thriller 'Crawlers' Digitally Nov. 10, Disc Dec. 22
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